[Hub]/) : Traits : Lung FVC : ← →

chr11:60,965,461-63,284,510

Best TWAS P=2.73e-30 · Best GWAS P=9.54e-29 conditioned to 0.0499

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ROM1	0.25	0.17	lasso	3	0.18	1.5e-14	11.08	-11.0	6.0e-28	-0.98	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	EML3	0.07	0.00	enet	22	0.02	6.0e-03	1.50	6.4	2.0e-10	0.54	0.03	0.74	FALSE
3	GTEx	Adipose Visceral Omentum	ROM1	0.29	0.16	lasso	8	0.23	3.7e-12	10.40	-10.9	1.4e-27	-0.96	0.01	0.99	FALSE
4	GTEx	Artery Aorta	ROM1	0.18	0.17	lasso	7	0.16	3.3e-09	10.89	-11.1	1.7e-28	-0.96	0.02	0.98	FALSE
5	GTEx	Artery Tibial	ROM1	0.14	0.05	lasso	6	0.03	2.5e-03	11.08	-10.8	2.8e-27	-0.97	0.01	0.98	FALSE
6	GTEx	Artery Tibial	TTC9C	0.09	0.10	lasso	2	0.10	6.5e-08	6.08	6.1	1.2e-09	0.41	0.98	0.00	FALSE
7	GTEx	Breast Mammary Tissue	ROM1	0.10	0.09	lasso	5	0.06	5.4e-04	10.89	-10.9	1.5e-27	-0.96	0.02	0.97	FALSE
8	GTEx	Breast Mammary Tissue (Male)	ROM1	0.17	0.00	enet	18	0.01	2.2e-01	10.77	-8.8	9.1e-19	-0.72	0.03	0.52	FALSE
9	GTEx	Breast Mammary Tissue (Female)	ROM1	0.16	0.02	lasso	4	0.04	2.9e-02	10.40	-10.6	3.5e-26	-0.93	0.02	0.83	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EML3	0.33	0.22	lasso	8	0.21	1.6e-07	10.37	10.2	3.3e-24	0.94	0.02	0.98	FALSE
11	GTEx	Cells Transformed fibroblasts	MTA2	0.06	0.09	lasso	1	0.07	3.0e-06	9.14	9.1	6.3e-20	0.85	0.03	0.97	FALSE
12	GTEx	Cells Transformed fibroblasts	EML3	0.19	0.16	lasso	9	0.18	7.3e-14	9.16	10.3	5.4e-25	0.93	0.04	0.96	FALSE
13	GTEx	Cells Transformed fibroblasts	TTC9C	0.19	0.16	enet	19	0.18	1.1e-13	5.96	5.8	5.3e-09	0.43	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	HNRNPUL2	0.11	0.04	enet	14	0.05	9.8e-05	6.13	-8.1	6.5e-16	-0.61	0.93	0.00	FALSE
15	GTEx	Esophagus Mucosa	MTA2	0.29	0.34	lasso	5	0.33	6.9e-23	11.05	11.0	4.0e-28	0.96	0.01	0.99	FALSE
16	GTEx	Esophagus Mucosa	EML3	0.40	0.43	lasso	8	0.46	1.8e-33	10.92	11.0	2.8e-28	0.97	0.02	0.98	FALSE
17	GTEx	Esophagus Mucosa	TTC9C	0.20	0.09	lasso	6	0.10	3.3e-07	6.00	5.2	1.8e-07	0.39	0.85	0.01	FALSE
18	GTEx	Esophagus Muscularis	TTC9C	0.11	0.06	lasso	3	0.01	7.0e-02	5.84	5.9	4.2e-09	0.43	0.43	0.05	FALSE
19	GTEx	Lung	ROM1	0.25	0.18	enet	13	0.20	2.2e-15	11.08	-11.0	3.4e-28	-0.97	0.01	0.99	FALSE
20	GTEx	Lung	EML3	0.07	0.04	lasso	3	0.01	2.5e-02	10.77	10.9	1.4e-27	0.97	0.02	0.95	FALSE
21	GTEx	Nerve Tibial	ROM1	0.15	0.06	lasso	7	0.06	2.9e-05	11.12	-9.1	6.2e-20	-0.91	0.01	0.99	FALSE
22	GTEx	Nerve Tibial	EML3	0.17	0.10	lasso	4	0.09	3.9e-07	10.77	11.1	2.1e-28	0.96	0.04	0.96	FALSE
23	GTEx	Nerve Tibial	B3GAT3	0.18	0.11	lasso	3	0.09	4.7e-07	8.49	8.4	5.0e-17	0.70	0.77	0.20	FALSE
24	GTEx	Nerve Tibial	TTC9C	0.09	0.05	lasso	7	0.04	1.6e-03	6.00	6.0	1.4e-09	0.42	0.89	0.00	FALSE
25	GTEx	Ovary	ROM1	0.25	0.00	lasso	5	0.00	3.3e-01	9.14	-10.5	6.7e-26	-0.95	0.02	0.83	FALSE
26	GTEx	Pituitary	STX5	0.22	0.11	lasso	3	0.11	9.7e-04	0.62	-6.7	1.6e-11	-0.56	0.03	0.69	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	ROM1	0.15	0.08	lasso	1	0.06	2.8e-04	8.97	-9.0	2.8e-19	-0.73	0.03	0.81	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	EML3	0.20	0.19	lasso	3	0.24	2.7e-13	10.77	11.0	3.1e-28	0.96	0.04	0.96	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	B3GAT3	0.18	0.11	lasso	3	0.11	9.8e-07	8.49	9.1	9.9e-20	0.80	0.73	0.25	FALSE
30	GTEx	Skin Sun Exposed Lower leg	MTA2	0.14	0.04	enet	21	0.05	3.1e-05	11.08	9.8	1.5e-22	0.78	0.02	0.97	FALSE
31	GTEx	Skin Sun Exposed Lower leg	ROM1	0.13	0.11	lasso	4	0.10	9.7e-09	11.08	-10.9	6.9e-28	-0.96	0.01	0.99	FALSE
32	GTEx	Skin Sun Exposed Lower leg	EML3	0.32	0.25	enet	19	0.26	8.0e-22	10.77	10.9	1.3e-27	0.94	0.12	0.88	FALSE
33	GTEx	Skin Sun Exposed Lower leg	TTC9C	0.17	0.16	enet	13	0.17	2.7e-14	5.84	6.1	1.4e-09	0.45	1.00	0.00	FALSE
34	GTEx	Spleen	GANAB	0.35	-0.01	lasso	9	0.01	1.3e-01	10.77	11.1	1.7e-28	0.88	0.03	0.65	FALSE
35	GTEx	Spleen	MTA2	0.26	0.07	enet	19	0.07	8.7e-03	10.40	9.6	1.3e-21	0.81	0.02	0.88	FALSE
36	GTEx	Spleen	RAB3IL1	0.32	0.06	enet	16	0.06	1.2e-02	-6.15	6.0	2.4e-09	-0.01	0.01	0.91	FALSE
37	GTEx	Stomach	EML3	0.11	0.04	enet	5	0.03	2.1e-02	9.03	10.3	4.5e-25	0.94	0.02	0.86	FALSE
38	GTEx	Testis	EML3	0.27	0.22	enet	15	0.29	2.7e-13	11.05	10.9	1.2e-27	0.97	0.01	0.99	FALSE
39	GTEx	Testis	TTC9C	0.23	0.14	enet	19	0.12	8.3e-06	6.00	5.6	2.4e-08	0.37	0.89	0.01	FALSE
40	GTEx	Thyroid	ROM1	0.17	0.16	lasso	8	0.16	3.6e-12	10.79	-11.1	1.8e-28	-0.98	0.01	0.99	FALSE
41	GTEx	Thyroid	EML3	0.10	0.11	lasso	4	0.10	5.9e-08	10.77	10.8	2.4e-27	0.96	0.03	0.97	FALSE
42	GTEx	Thyroid	B3GAT3	0.18	0.09	lasso	5	0.12	1.4e-09	8.49	8.9	3.7e-19	0.73	0.23	0.77	FALSE
43	GTEx	Thyroid	TTC9C	0.15	0.13	lasso	7	0.14	1.6e-10	5.84	5.9	2.9e-09	0.41	1.00	0.00	FALSE
44	GTEx	Whole Blood	EML3	0.17	0.09	lasso	7	0.08	6.3e-08	10.89	10.8	3.0e-27	0.96	0.02	0.98	FALSE
45	METSIM	Adipose	B3GAT3	0.08	0.06	enet	16	0.07	5.4e-11	10.34	9.7	4.2e-22	0.85	0.10	0.90	FALSE
46	METSIM	Adipose	EEF1G	0.08	0.05	bslmm	375	0.06	4.5e-09	11.12	-8.8	8.7e-19	-0.88	0.02	0.98	FALSE
47	METSIM	Adipose	EML3	0.15	0.14	bslmm	376	0.14	1.9e-20	10.90	9.9	2.6e-23	0.93	0.02	0.98	FALSE
48	METSIM	Adipose	ROM1	0.05	0.02	enet	17	0.02	9.9e-05	11.05	-7.6	2.9e-14	-0.79	0.02	0.98	FALSE
49	METSIM	Adipose	TTC9C	0.07	0.07	enet	25	0.08	1.4e-12	5.65	8.8	2.0e-18	0.70	0.30	0.70	FALSE
50	NTR	Blood	BSCL2	0.05	0.02	enet	15	0.06	2.1e-17	5.84	-6.9	4.3e-12	-0.53	1.00	0.00	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	RAB3IL1	0.09	0.09	lasso	4	0.09	3.3e-11	-6.15	6.0	1.4e-09	-0.01	0.32	0.68	FALSE
52	YFS	Blood	EEF1G	0.30	0.45	lasso	6	0.45	3.6e-166	10.89	-10.9	1.4e-27	-0.96	0.04	0.96	FALSE
53	YFS	Blood	EML3	0.20	0.31	lasso	12	0.33	1.3e-110	11.12	11.3	1.9e-29	0.98	0.00	1.00	FALSE
54	YFS	Blood	INTS5	0.09	0.12	lasso	4	0.12	1.9e-38	8.49	9.5	2.8e-21	0.81	1.00	0.00	FALSE
55	YFS	Blood	TTC9C	0.05	0.04	bslmm	336	0.04	9.3e-14	5.90	5.6	2.0e-08	0.37	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEF1G	0.04	0.05	lasso	1	0.04	1.1e-04	11.08	-11.1	1.5e-28	-0.98	0.01	0.97	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf83	0.01	0.00	blup	23	0.01	4.2e-03	10.34	-9.4	4.6e-21	-0.75	0.01	0.72	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	EEF1G	0.02	0.04	lasso	2	0.03	6.3e-07	10.92	-10.9	1.5e-27	-0.96	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	EML3	0.02	0.02	lasso	4	0.02	2.5e-05	11.12	11.1	8.1e-29	1.00	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROM1	0.01	0.02	enet	4	0.02	2.4e-04	11.08	-11.1	1.5e-28	-0.97	0.01	0.98	FALSE
61	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EML3	0.14	0.04	enet	6	0.07	2.2e-04	2.32	6.0	2.2e-09	0.65	0.01	0.59	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	EEF1G	0.07	0.11	lasso	1	0.11	9.2e-07	10.37	-10.4	3.3e-25	-0.96	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	EML3	0.07	0.03	blup	29	0.05	6.5e-04	9.14	10.4	1.9e-25	0.89	0.01	0.90	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	RPLP0P2	0.10	0.06	blup	30	0.07	5.6e-05	-4.02	-5.3	1.2e-07	0.05	0.01	0.41	TRUE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	TTC9C	0.05	0.06	enet	8	0.05	1.0e-03	6.13	6.1	1.3e-09	0.41	0.01	0.98	FALSE
66	The Cancer Genome Atlas	Glioblastoma Multiforme	RAB3IL1	0.13	0.10	lasso	2	0.09	1.2e-03	-6.15	6.5	1.1e-10	-0.01	0.01	0.85	TRUE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EEF1G	0.10	0.09	blup	26	0.09	9.8e-11	10.37	-9.1	9.1e-20	-0.87	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EML3	0.06	0.05	blup	27	0.06	7.6e-07	10.28	10.3	1.0e-24	0.92	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ROM1	0.04	0.02	blup	22	0.02	6.2e-03	9.14	-9.2	2.5e-20	-0.88	0.01	0.81	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTC9C	0.04	0.04	enet	7	0.04	4.4e-05	6.05	6.1	1.1e-09	0.39	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EEF1G	0.11	0.12	blup	27	0.13	5.5e-14	11.08	-11.4	3.3e-30	-0.95	0.01	0.99	TRUE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML3	0.04	0.06	lasso	3	0.06	1.7e-07	10.77	10.8	3.6e-27	0.97	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB3IL1	0.05	0.03	lasso	1	0.01	3.0e-02	-6.15	6.2	7.8e-10	-0.01	0.05	0.31	FALSE
74	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EEF1G	0.07	0.04	blup	28	0.07	9.8e-05	9.14	-9.3	8.9e-21	-0.91	0.03	0.87	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EML3	0.06	0.09	lasso	2	0.08	1.6e-05	10.34	10.6	4.7e-26	0.89	0.02	0.97	FALSE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTC9C	0.03	0.03	blup	30	0.02	2.6e-02	5.96	5.9	4.2e-09	0.39	0.01	0.73	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf83	0.02	0.01	blup	24	0.01	1.5e-02	10.33	-9.8	1.0e-22	-0.79	0.00	0.93	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEF1G	0.06	0.07	blup	27	0.07	8.1e-09	10.90	-11.4	2.7e-30	-0.93	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	EML3	0.03	0.04	blup	28	0.03	7.6e-05	11.12	11.1	2.1e-28	0.96	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAB3IL1	0.11	0.11	lasso	4	0.10	9.7e-12	-6.15	6.2	5.6e-10	0.00	0.35	0.65	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTC9C	0.06	0.10	lasso	2	0.09	6.6e-11	5.96	6.0	1.7e-09	0.41	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EEF1G	0.06	0.03	blup	27	0.04	4.5e-03	10.34	-10.4	2.4e-25	-0.95	0.01	0.71	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	EEF1G	0.06	0.08	lasso	8	0.08	5.9e-10	10.90	-10.5	1.2e-25	-0.94	0.02	0.98	FALSE
84	The Cancer Genome Atlas	Lung Adenocarcinoma	EML3	0.03	0.03	blup	28	0.03	8.4e-05	10.90	11.4	3.5e-30	0.97	0.02	0.98	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	ROM1	0.04	0.04	blup	23	0.04	9.5e-06	10.92	-10.7	1.1e-26	-0.96	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	TTC9C	0.02	0.01	blup	32	0.01	3.2e-02	5.90	6.0	1.7e-09	0.42	0.01	0.88	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf83	0.07	0.01	blup	24	0.01	1.0e-02	8.49	-8.4	3.1e-17	-0.73	0.01	0.81	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EEF1G	0.08	0.13	lasso	4	0.12	3.1e-13	10.89	-10.9	1.2e-27	-0.96	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EML3	0.04	0.05	blup	27	0.05	3.5e-06	11.08	10.6	4.7e-26	0.93	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTC9C	0.03	0.02	blup	32	0.02	8.0e-04	5.65	5.9	4.3e-09	0.39	0.01	0.94	FALSE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML3	0.03	0.02	blup	27	0.03	3.5e-03	11.08	11.0	2.3e-28	0.96	0.01	0.79	FALSE
92	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C11orf83	0.11	0.01	lasso	3	0.02	4.0e-02	0.29	-6.4	1.9e-10	-0.58	0.00	0.59	FALSE
93	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EEF1G	0.08	0.08	blup	27	0.05	3.6e-03	10.90	-11.1	1.3e-28	-0.95	0.02	0.93	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ROM1	0.16	0.08	blup	23	0.07	5.7e-04	11.05	-8.7	2.7e-18	-0.76	0.01	0.88	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EEF1G	0.08	0.00	blup	27	0.04	1.3e-02	10.90	-10.5	1.3e-25	-0.91	0.02	0.82	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf83	0.03	0.03	blup	24	0.02	5.5e-03	9.03	-9.4	3.9e-21	-0.77	0.03	0.90	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	EEF1G	0.08	0.13	lasso	2	0.12	1.8e-12	10.88	-10.9	1.4e-27	-0.96	0.02	0.98	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	EML3	0.09	0.14	lasso	1	0.14	3.4e-14	11.08	11.1	1.5e-28	0.98	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTC9C	0.08	0.10	lasso	2	0.10	4.0e-11	6.05	6.0	1.5e-09	0.42	0.01	0.99	FALSE
100	The Cancer Genome Atlas	Rectum Adenocarcinoma	EML3	0.36	0.08	blup	27	0.19	3.7e-05	11.12	9.3	1.9e-20	0.82	0.01	0.84	FALSE
101	The Cancer Genome Atlas	Soft Tissue Sarcoma	ROM1	0.06	0.05	blup	24	0.03	8.1e-03	10.92	-11.0	6.5e-28	-0.97	0.01	0.89	FALSE
102	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EML3	0.32	0.03	lasso	2	0.07	4.9e-03	9.03	7.3	2.6e-13	0.76	0.01	0.51	FALSE
103	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ROM1	0.35	0.12	blup	24	0.14	1.1e-04	11.05	-7.6	2.6e-14	-0.70	0.01	0.88	FALSE
104	The Cancer Genome Atlas	Stomach Adenocarcinoma	EEF1G	0.05	0.07	blup	27	0.07	1.7e-05	10.37	-11.2	2.7e-29	-0.96	0.02	0.98	FALSE
105	The Cancer Genome Atlas	Stomach Adenocarcinoma	ROM1	0.05	0.08	lasso	3	0.08	3.1e-06	10.77	-10.6	3.1e-26	-0.96	0.01	0.98	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	EEF1G	0.15	0.27	blup	27	0.28	3.6e-27	11.05	-10.7	7.5e-27	-0.91	0.01	0.99	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	EML3	0.11	0.10	blup	28	0.12	2.3e-11	11.08	11.4	5.8e-30	0.92	0.01	0.99	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	ROM1	0.03	0.02	blup	23	0.02	1.1e-02	11.05	-10.7	1.2e-26	-0.96	0.01	0.93	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	TTC9C	0.09	0.08	blup	32	0.08	2.0e-08	6.05	6.0	1.5e-09	0.38	0.02	0.98	FALSE