[Hub]/) : Traits : Lung FVC :

chr11:60,965,461-63,284,510

Best TWAS P=2.73e-30 · Best GWAS P=9.54e-29 conditioned to 0.0499

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ROM1 0.25 0.17 lasso 3 0.18 1.5e-14 11.08 -11.0 6.0e-28 -0.98 0.01 0.99 FALSE
2 GTEx Adipose Subcutaneous EML3 0.07 0.00 enet 22 0.02 6.0e-03 1.50 6.4 2.0e-10 0.54 0.03 0.74 FALSE
3 GTEx Adipose Visceral Omentum ROM1 0.29 0.16 lasso 8 0.23 3.7e-12 10.40 -10.9 1.4e-27 -0.96 0.01 0.99 FALSE
4 GTEx Artery Aorta ROM1 0.18 0.17 lasso 7 0.16 3.3e-09 10.89 -11.1 1.7e-28 -0.96 0.02 0.98 FALSE
5 GTEx Artery Tibial ROM1 0.14 0.05 lasso 6 0.03 2.5e-03 11.08 -10.8 2.8e-27 -0.97 0.01 0.98 FALSE
6 GTEx Artery Tibial TTC9C 0.09 0.10 lasso 2 0.10 6.5e-08 6.08 6.1 1.2e-09 0.41 0.98 0.00 FALSE
7 GTEx Breast Mammary Tissue ROM1 0.10 0.09 lasso 5 0.06 5.4e-04 10.89 -10.9 1.5e-27 -0.96 0.02 0.97 FALSE
8 GTEx Breast Mammary Tissue (Male) ROM1 0.17 0.00 enet 18 0.01 2.2e-01 10.77 -8.8 9.1e-19 -0.72 0.03 0.52 FALSE
9 GTEx Breast Mammary Tissue (Female) ROM1 0.16 0.02 lasso 4 0.04 2.9e-02 10.40 -10.6 3.5e-26 -0.93 0.02 0.83 FALSE
10 GTEx Cells EBV-transformed lymphocytes EML3 0.33 0.22 lasso 8 0.21 1.6e-07 10.37 10.2 3.3e-24 0.94 0.02 0.98 FALSE
11 GTEx Cells Transformed fibroblasts MTA2 0.06 0.09 lasso 1 0.07 3.0e-06 9.14 9.1 6.3e-20 0.85 0.03 0.97 FALSE
12 GTEx Cells Transformed fibroblasts EML3 0.19 0.16 lasso 9 0.18 7.3e-14 9.16 10.3 5.4e-25 0.93 0.04 0.96 FALSE
13 GTEx Cells Transformed fibroblasts TTC9C 0.19 0.16 enet 19 0.18 1.1e-13 5.96 5.8 5.3e-09 0.43 1.00 0.00 FALSE
14 GTEx Cells Transformed fibroblasts HNRNPUL2 0.11 0.04 enet 14 0.05 9.8e-05 6.13 -8.1 6.5e-16 -0.61 0.93 0.00 FALSE
15 GTEx Esophagus Mucosa MTA2 0.29 0.34 lasso 5 0.33 6.9e-23 11.05 11.0 4.0e-28 0.96 0.01 0.99 FALSE
16 GTEx Esophagus Mucosa EML3 0.40 0.43 lasso 8 0.46 1.8e-33 10.92 11.0 2.8e-28 0.97 0.02 0.98 FALSE
17 GTEx Esophagus Mucosa TTC9C 0.20 0.09 lasso 6 0.10 3.3e-07 6.00 5.2 1.8e-07 0.39 0.85 0.01 FALSE
18 GTEx Esophagus Muscularis TTC9C 0.11 0.06 lasso 3 0.01 7.0e-02 5.84 5.9 4.2e-09 0.43 0.43 0.05 FALSE
19 GTEx Lung ROM1 0.25 0.18 enet 13 0.20 2.2e-15 11.08 -11.0 3.4e-28 -0.97 0.01 0.99 FALSE
20 GTEx Lung EML3 0.07 0.04 lasso 3 0.01 2.5e-02 10.77 10.9 1.4e-27 0.97 0.02 0.95 FALSE
21 GTEx Nerve Tibial ROM1 0.15 0.06 lasso 7 0.06 2.9e-05 11.12 -9.1 6.2e-20 -0.91 0.01 0.99 FALSE
22 GTEx Nerve Tibial EML3 0.17 0.10 lasso 4 0.09 3.9e-07 10.77 11.1 2.1e-28 0.96 0.04 0.96 FALSE
23 GTEx Nerve Tibial B3GAT3 0.18 0.11 lasso 3 0.09 4.7e-07 8.49 8.4 5.0e-17 0.70 0.77 0.20 FALSE
24 GTEx Nerve Tibial TTC9C 0.09 0.05 lasso 7 0.04 1.6e-03 6.00 6.0 1.4e-09 0.42 0.89 0.00 FALSE
25 GTEx Ovary ROM1 0.25 0.00 lasso 5 0.00 3.3e-01 9.14 -10.5 6.7e-26 -0.95 0.02 0.83 FALSE
26 GTEx Pituitary STX5 0.22 0.11 lasso 3 0.11 9.7e-04 0.62 -6.7 1.6e-11 -0.56 0.03 0.69 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic ROM1 0.15 0.08 lasso 1 0.06 2.8e-04 8.97 -9.0 2.8e-19 -0.73 0.03 0.81 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic EML3 0.20 0.19 lasso 3 0.24 2.7e-13 10.77 11.0 3.1e-28 0.96 0.04 0.96 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic B3GAT3 0.18 0.11 lasso 3 0.11 9.8e-07 8.49 9.1 9.9e-20 0.80 0.73 0.25 FALSE
30 GTEx Skin Sun Exposed Lower leg MTA2 0.14 0.04 enet 21 0.05 3.1e-05 11.08 9.8 1.5e-22 0.78 0.02 0.97 FALSE
31 GTEx Skin Sun Exposed Lower leg ROM1 0.13 0.11 lasso 4 0.10 9.7e-09 11.08 -10.9 6.9e-28 -0.96 0.01 0.99 FALSE
32 GTEx Skin Sun Exposed Lower leg EML3 0.32 0.25 enet 19 0.26 8.0e-22 10.77 10.9 1.3e-27 0.94 0.12 0.88 FALSE
33 GTEx Skin Sun Exposed Lower leg TTC9C 0.17 0.16 enet 13 0.17 2.7e-14 5.84 6.1 1.4e-09 0.45 1.00 0.00 FALSE
34 GTEx Spleen GANAB 0.35 -0.01 lasso 9 0.01 1.3e-01 10.77 11.1 1.7e-28 0.88 0.03 0.65 FALSE
35 GTEx Spleen MTA2 0.26 0.07 enet 19 0.07 8.7e-03 10.40 9.6 1.3e-21 0.81 0.02 0.88 FALSE
36 GTEx Spleen RAB3IL1 0.32 0.06 enet 16 0.06 1.2e-02 -6.15 6.0 2.4e-09 -0.01 0.01 0.91 FALSE
37 GTEx Stomach EML3 0.11 0.04 enet 5 0.03 2.1e-02 9.03 10.3 4.5e-25 0.94 0.02 0.86 FALSE
38 GTEx Testis EML3 0.27 0.22 enet 15 0.29 2.7e-13 11.05 10.9 1.2e-27 0.97 0.01 0.99 FALSE
39 GTEx Testis TTC9C 0.23 0.14 enet 19 0.12 8.3e-06 6.00 5.6 2.4e-08 0.37 0.89 0.01 FALSE
40 GTEx Thyroid ROM1 0.17 0.16 lasso 8 0.16 3.6e-12 10.79 -11.1 1.8e-28 -0.98 0.01 0.99 FALSE
41 GTEx Thyroid EML3 0.10 0.11 lasso 4 0.10 5.9e-08 10.77 10.8 2.4e-27 0.96 0.03 0.97 FALSE
42 GTEx Thyroid B3GAT3 0.18 0.09 lasso 5 0.12 1.4e-09 8.49 8.9 3.7e-19 0.73 0.23 0.77 FALSE
43 GTEx Thyroid TTC9C 0.15 0.13 lasso 7 0.14 1.6e-10 5.84 5.9 2.9e-09 0.41 1.00 0.00 FALSE
44 GTEx Whole Blood EML3 0.17 0.09 lasso 7 0.08 6.3e-08 10.89 10.8 3.0e-27 0.96 0.02 0.98 FALSE
45 METSIM Adipose B3GAT3 0.08 0.06 enet 16 0.07 5.4e-11 10.34 9.7 4.2e-22 0.85 0.10 0.90 FALSE
46 METSIM Adipose EEF1G 0.08 0.05 bslmm 375 0.06 4.5e-09 11.12 -8.8 8.7e-19 -0.88 0.02 0.98 FALSE
47 METSIM Adipose EML3 0.15 0.14 bslmm 376 0.14 1.9e-20 10.90 9.9 2.6e-23 0.93 0.02 0.98 FALSE
48 METSIM Adipose ROM1 0.05 0.02 enet 17 0.02 9.9e-05 11.05 -7.6 2.9e-14 -0.79 0.02 0.98 FALSE
49 METSIM Adipose TTC9C 0.07 0.07 enet 25 0.08 1.4e-12 5.65 8.8 2.0e-18 0.70 0.30 0.70 FALSE
50 NTR Blood BSCL2 0.05 0.02 enet 15 0.06 2.1e-17 5.84 -6.9 4.3e-12 -0.53 1.00 0.00 FALSE
51 ROSMAP Brain Pre-frontal Cortex RAB3IL1 0.09 0.09 lasso 4 0.09 3.3e-11 -6.15 6.0 1.4e-09 -0.01 0.32 0.68 FALSE
52 YFS Blood EEF1G 0.30 0.45 lasso 6 0.45 3.6e-166 10.89 -10.9 1.4e-27 -0.96 0.04 0.96 FALSE
53 YFS Blood EML3 0.20 0.31 lasso 12 0.33 1.3e-110 11.12 11.3 1.9e-29 0.98 0.00 1.00 FALSE
54 YFS Blood INTS5 0.09 0.12 lasso 4 0.12 1.9e-38 8.49 9.5 2.8e-21 0.81 1.00 0.00 FALSE
55 YFS Blood TTC9C 0.05 0.04 bslmm 336 0.04 9.3e-14 5.90 5.6 2.0e-08 0.37 1.00 0.00 FALSE
56 The Cancer Genome Atlas Bladder Urothelial Carcinoma EEF1G 0.04 0.05 lasso 1 0.04 1.1e-04 11.08 -11.1 1.5e-28 -0.98 0.01 0.97 FALSE
57 The Cancer Genome Atlas Breast Invasive Carcinoma C11orf83 0.01 0.00 blup 23 0.01 4.2e-03 10.34 -9.4 4.6e-21 -0.75 0.01 0.72 FALSE
58 The Cancer Genome Atlas Breast Invasive Carcinoma EEF1G 0.02 0.04 lasso 2 0.03 6.3e-07 10.92 -10.9 1.5e-27 -0.96 0.02 0.98 FALSE
59 The Cancer Genome Atlas Breast Invasive Carcinoma EML3 0.02 0.02 lasso 4 0.02 2.5e-05 11.12 11.1 8.1e-29 1.00 0.01 0.99 FALSE
60 The Cancer Genome Atlas Breast Invasive Carcinoma ROM1 0.01 0.02 enet 4 0.02 2.4e-04 11.08 -11.1 1.5e-28 -0.97 0.01 0.98 FALSE
61 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma EML3 0.14 0.04 enet 6 0.07 2.2e-04 2.32 6.0 2.2e-09 0.65 0.01 0.59 FALSE
62 The Cancer Genome Atlas Colon Adenocarcinoma EEF1G 0.07 0.11 lasso 1 0.11 9.2e-07 10.37 -10.4 3.3e-25 -0.96 0.02 0.98 FALSE
63 The Cancer Genome Atlas Colon Adenocarcinoma EML3 0.07 0.03 blup 29 0.05 6.5e-04 9.14 10.4 1.9e-25 0.89 0.01 0.90 FALSE
64 The Cancer Genome Atlas Colon Adenocarcinoma RPLP0P2 0.10 0.06 blup 30 0.07 5.6e-05 -4.02 -5.3 1.2e-07 0.05 0.01 0.41 TRUE
65 The Cancer Genome Atlas Colon Adenocarcinoma TTC9C 0.05 0.06 enet 8 0.05 1.0e-03 6.13 6.1 1.3e-09 0.41 0.01 0.98 FALSE
66 The Cancer Genome Atlas Glioblastoma Multiforme RAB3IL1 0.13 0.10 lasso 2 0.09 1.2e-03 -6.15 6.5 1.1e-10 -0.01 0.01 0.85 TRUE
67 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EEF1G 0.10 0.09 blup 26 0.09 9.8e-11 10.37 -9.1 9.1e-20 -0.87 0.03 0.97 FALSE
68 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EML3 0.06 0.05 blup 27 0.06 7.6e-07 10.28 10.3 1.0e-24 0.92 0.02 0.98 FALSE
69 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ROM1 0.04 0.02 blup 22 0.02 6.2e-03 9.14 -9.2 2.5e-20 -0.88 0.01 0.81 FALSE
70 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TTC9C 0.04 0.04 enet 7 0.04 4.4e-05 6.05 6.1 1.1e-09 0.39 0.01 0.99 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EEF1G 0.11 0.12 blup 27 0.13 5.5e-14 11.08 -11.4 3.3e-30 -0.95 0.01 0.99 TRUE
72 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EML3 0.04 0.06 lasso 3 0.06 1.7e-07 10.77 10.8 3.6e-27 0.97 0.02 0.98 FALSE
73 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB3IL1 0.05 0.03 lasso 1 0.01 3.0e-02 -6.15 6.2 7.8e-10 -0.01 0.05 0.31 FALSE
74 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EEF1G 0.07 0.04 blup 28 0.07 9.8e-05 9.14 -9.3 8.9e-21 -0.91 0.03 0.87 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EML3 0.06 0.09 lasso 2 0.08 1.6e-05 10.34 10.6 4.7e-26 0.89 0.02 0.97 FALSE
76 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TTC9C 0.03 0.03 blup 30 0.02 2.6e-02 5.96 5.9 4.2e-09 0.39 0.01 0.73 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma C11orf83 0.02 0.01 blup 24 0.01 1.5e-02 10.33 -9.8 1.0e-22 -0.79 0.00 0.93 FALSE
78 The Cancer Genome Atlas Brain Lower Grade Glioma EEF1G 0.06 0.07 blup 27 0.07 8.1e-09 10.90 -11.4 2.7e-30 -0.93 0.02 0.98 FALSE
79 The Cancer Genome Atlas Brain Lower Grade Glioma EML3 0.03 0.04 blup 28 0.03 7.6e-05 11.12 11.1 2.1e-28 0.96 0.01 0.99 FALSE
80 The Cancer Genome Atlas Brain Lower Grade Glioma RAB3IL1 0.11 0.11 lasso 4 0.10 9.7e-12 -6.15 6.2 5.6e-10 0.00 0.35 0.65 FALSE
81 The Cancer Genome Atlas Brain Lower Grade Glioma TTC9C 0.06 0.10 lasso 2 0.09 6.6e-11 5.96 6.0 1.7e-09 0.41 0.01 0.99 FALSE
82 The Cancer Genome Atlas Liver Hepatocellular Carcinoma EEF1G 0.06 0.03 blup 27 0.04 4.5e-03 10.34 -10.4 2.4e-25 -0.95 0.01 0.71 FALSE
83 The Cancer Genome Atlas Lung Adenocarcinoma EEF1G 0.06 0.08 lasso 8 0.08 5.9e-10 10.90 -10.5 1.2e-25 -0.94 0.02 0.98 FALSE
84 The Cancer Genome Atlas Lung Adenocarcinoma EML3 0.03 0.03 blup 28 0.03 8.4e-05 10.90 11.4 3.5e-30 0.97 0.02 0.98 FALSE
85 The Cancer Genome Atlas Lung Adenocarcinoma ROM1 0.04 0.04 blup 23 0.04 9.5e-06 10.92 -10.7 1.1e-26 -0.96 0.01 0.99 FALSE
86 The Cancer Genome Atlas Lung Adenocarcinoma TTC9C 0.02 0.01 blup 32 0.01 3.2e-02 5.90 6.0 1.7e-09 0.42 0.01 0.88 FALSE
87 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C11orf83 0.07 0.01 blup 24 0.01 1.0e-02 8.49 -8.4 3.1e-17 -0.73 0.01 0.81 FALSE
88 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EEF1G 0.08 0.13 lasso 4 0.12 3.1e-13 10.89 -10.9 1.2e-27 -0.96 0.02 0.98 FALSE
89 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EML3 0.04 0.05 blup 27 0.05 3.5e-06 11.08 10.6 4.7e-26 0.93 0.01 0.99 FALSE
90 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TTC9C 0.03 0.02 blup 32 0.02 8.0e-04 5.65 5.9 4.3e-09 0.39 0.01 0.94 FALSE
91 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma EML3 0.03 0.02 blup 27 0.03 3.5e-03 11.08 11.0 2.3e-28 0.96 0.01 0.79 FALSE
92 The Cancer Genome Atlas Pancreatic Adenocarcinoma C11orf83 0.11 0.01 lasso 3 0.02 4.0e-02 0.29 -6.4 1.9e-10 -0.58 0.00 0.59 FALSE
93 The Cancer Genome Atlas Pancreatic Adenocarcinoma EEF1G 0.08 0.08 blup 27 0.05 3.6e-03 10.90 -11.1 1.3e-28 -0.95 0.02 0.93 FALSE
94 The Cancer Genome Atlas Pancreatic Adenocarcinoma ROM1 0.16 0.08 blup 23 0.07 5.7e-04 11.05 -8.7 2.7e-18 -0.76 0.01 0.88 FALSE
95 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma EEF1G 0.08 0.00 blup 27 0.04 1.3e-02 10.90 -10.5 1.3e-25 -0.91 0.02 0.82 FALSE
96 The Cancer Genome Atlas Prostate Adenocarcinoma C11orf83 0.03 0.03 blup 24 0.02 5.5e-03 9.03 -9.4 3.9e-21 -0.77 0.03 0.90 FALSE
97 The Cancer Genome Atlas Prostate Adenocarcinoma EEF1G 0.08 0.13 lasso 2 0.12 1.8e-12 10.88 -10.9 1.4e-27 -0.96 0.02 0.98 FALSE
98 The Cancer Genome Atlas Prostate Adenocarcinoma EML3 0.09 0.14 lasso 1 0.14 3.4e-14 11.08 11.1 1.5e-28 0.98 0.00 1.00 FALSE
99 The Cancer Genome Atlas Prostate Adenocarcinoma TTC9C 0.08 0.10 lasso 2 0.10 4.0e-11 6.05 6.0 1.5e-09 0.42 0.01 0.99 FALSE
100 The Cancer Genome Atlas Rectum Adenocarcinoma EML3 0.36 0.08 blup 27 0.19 3.7e-05 11.12 9.3 1.9e-20 0.82 0.01 0.84 FALSE
101 The Cancer Genome Atlas Soft Tissue Sarcoma ROM1 0.06 0.05 blup 24 0.03 8.1e-03 10.92 -11.0 6.5e-28 -0.97 0.01 0.89 FALSE
102 The Cancer Genome Atlas Skin Cutaneous Melanoma EML3 0.32 0.03 lasso 2 0.07 4.9e-03 9.03 7.3 2.6e-13 0.76 0.01 0.51 FALSE
103 The Cancer Genome Atlas Skin Cutaneous Melanoma ROM1 0.35 0.12 blup 24 0.14 1.1e-04 11.05 -7.6 2.6e-14 -0.70 0.01 0.88 FALSE
104 The Cancer Genome Atlas Stomach Adenocarcinoma EEF1G 0.05 0.07 blup 27 0.07 1.7e-05 10.37 -11.2 2.7e-29 -0.96 0.02 0.98 FALSE
105 The Cancer Genome Atlas Stomach Adenocarcinoma ROM1 0.05 0.08 lasso 3 0.08 3.1e-06 10.77 -10.6 3.1e-26 -0.96 0.01 0.98 FALSE
106 The Cancer Genome Atlas Thyroid Carcinoma EEF1G 0.15 0.27 blup 27 0.28 3.6e-27 11.05 -10.7 7.5e-27 -0.91 0.01 0.99 FALSE
107 The Cancer Genome Atlas Thyroid Carcinoma EML3 0.11 0.10 blup 28 0.12 2.3e-11 11.08 11.4 5.8e-30 0.92 0.01 0.99 FALSE
108 The Cancer Genome Atlas Thyroid Carcinoma ROM1 0.03 0.02 blup 23 0.02 1.1e-02 11.05 -10.7 1.2e-26 -0.96 0.01 0.93 FALSE
109 The Cancer Genome Atlas Thyroid Carcinoma TTC9C 0.09 0.08 blup 32 0.08 2.0e-08 6.05 6.0 1.5e-09 0.38 0.02 0.98 FALSE