[Hub]/) : Traits : Lung FVC : ← →

chr14:91,738,696-94,495,324

Best TWAS P=4.83e-31 · Best GWAS P=1.3e-30 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ATXN3	0.19	0.17	lasso	5	0.17	1.7e-13	6.35	6.5	7.0e-11	0.01	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-529H20.5	0.14	0.16	lasso	3	0.15	3.0e-12	6.35	7.0	2.5e-12	0.01	0.45	0.55	FALSE
3	GTEx	Adipose Subcutaneous	RP11-529H20.6	0.16	0.26	lasso	2	0.26	4.8e-21	6.56	6.6	5.4e-11	0.01	0.42	0.58	FALSE
4	GTEx	Adipose Visceral Omentum	ATXN3	0.19	0.14	lasso	6	0.12	7.0e-07	6.49	6.5	6.5e-11	0.00	0.99	0.01	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-529H20.5	0.19	0.05	lasso	6	0.08	9.9e-05	6.60	6.7	1.8e-11	0.02	0.09	0.91	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-529H20.6	0.26	0.29	lasso	4	0.28	1.1e-14	6.52	6.5	7.9e-11	0.01	0.53	0.47	FALSE
7	GTEx	Adrenal Gland	RP11-529H20.6	0.22	0.21	lasso	7	0.18	4.8e-07	6.55	6.3	2.7e-10	0.01	0.48	0.48	FALSE
8	GTEx	Artery Aorta	TRIP11	0.20	0.00	enet	8	0.02	4.0e-02	6.35	5.2	2.5e-07	0.02	0.16	0.22	FALSE
9	GTEx	Artery Aorta	RP11-529H20.6	0.20	0.14	lasso	4	0.18	6.4e-10	6.56	6.2	7.3e-10	0.02	0.54	0.45	FALSE
10	GTEx	Artery Coronary	ATXN3	0.21	0.20	lasso	2	0.24	1.4e-08	6.56	7.1	1.1e-12	0.04	0.90	0.01	FALSE
11	GTEx	Artery Coronary	TRIP11	0.18	0.01	lasso	3	0.00	3.2e-01	5.88	6.1	1.0e-09	0.02	0.09	0.22	FALSE
12	GTEx	Artery Tibial	ATXN3	0.13	0.11	lasso	3	0.10	5.8e-08	6.22	6.3	2.9e-10	0.00	1.00	0.00	FALSE
13	GTEx	Artery Tibial	RP11-529H20.5	0.07	0.00	lasso	4	0.00	4.7e-01	7.25	7.1	1.3e-12	0.02	0.02	0.92	FALSE
14	GTEx	Artery Tibial	RP11-529H20.6	0.20	0.22	lasso	8	0.22	2.3e-17	6.56	6.5	5.9e-11	0.01	0.59	0.41	FALSE
15	GTEx	Brain Cerebellum	ATXN3	0.26	-0.01	enet	70	0.02	6.3e-02	4.04	6.0	1.6e-09	0.10	0.09	0.10	FALSE
16	GTEx	Brain Putamen basal ganglia	RP11-529H20.6	0.44	0.14	enet	45	0.26	6.1e-07	7.15	6.5	8.3e-11	0.03	0.02	0.97	FALSE
17	GTEx	Breast Mammary Tissue	ATXN3	0.20	0.24	lasso	8	0.23	3.5e-12	6.56	6.5	6.5e-11	0.01	1.00	0.00	FALSE
18	GTEx	Breast Mammary Tissue	RP11-529H20.5	0.22	0.10	enet	23	0.12	1.1e-06	6.49	6.1	1.3e-09	0.03	0.24	0.76	FALSE
19	GTEx	Breast Mammary Tissue	RP11-529H20.6	0.20	0.23	enet	13	0.27	3.5e-14	6.56	6.5	6.3e-11	0.01	0.53	0.47	FALSE
20	GTEx	Breast Mammary Tissue (Female)	ATXN3	0.18	0.04	lasso	4	0.03	3.3e-02	6.22	6.4	1.2e-10	0.01	0.47	0.05	FALSE
21	GTEx	Breast Mammary Tissue (Female)	RP11-529H20.6	0.22	0.13	lasso	3	0.09	1.5e-03	6.49	6.5	8.3e-11	0.01	0.20	0.74	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	RP11-529H20.6	0.41	0.30	lasso	2	0.28	6.9e-10	6.56	6.3	3.4e-10	0.01	0.57	0.43	FALSE
23	GTEx	Cells Transformed fibroblasts	ATXN3	0.14	0.10	lasso	9	0.09	6.0e-07	6.35	6.2	4.9e-10	0.00	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	TRIP11	0.09	0.04	lasso	2	0.00	3.8e-01	6.55	6.3	2.5e-10	0.00	0.20	0.18	FALSE
25	GTEx	Cells Transformed fibroblasts	RP11-529H20.5	0.10	0.13	lasso	11	0.12	3.1e-09	6.37	6.4	1.5e-10	0.01	0.63	0.37	FALSE
26	GTEx	Cells Transformed fibroblasts	RP11-529H20.6	0.27	0.26	lasso	6	0.24	3.1e-18	6.56	6.7	2.7e-11	0.01	0.57	0.43	FALSE
27	GTEx	Colon Sigmoid	ATXN3	0.31	0.30	lasso	2	0.33	3.4e-12	6.56	6.4	1.4e-10	0.01	1.00	0.00	FALSE
28	GTEx	Colon Sigmoid	RIN3	0.24	0.17	lasso	6	0.11	9.3e-05	11.36	-11.6	4.8e-31	-0.97	0.00	0.99	TRUE
29	GTEx	Colon Sigmoid	RP11-529H20.5	0.27	0.05	lasso	8	0.04	1.9e-02	5.87	6.1	8.3e-10	0.02	0.14	0.70	FALSE
30	GTEx	Colon Sigmoid	RP11-529H20.6	0.24	0.24	lasso	3	0.27	4.8e-10	6.56	6.6	5.4e-11	0.01	0.57	0.43	FALSE
31	GTEx	Colon Transverse	RP11-529H20.6	0.18	0.14	lasso	5	0.18	3.7e-09	6.56	6.6	4.7e-11	0.03	0.57	0.43	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	TRIP11	0.16	0.13	lasso	11	0.12	3.7e-05	6.12	5.4	5.5e-08	-0.02	0.39	0.40	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	RP11-529H20.6	0.26	0.27	enet	26	0.26	6.2e-10	6.35	5.8	6.1e-09	0.00	0.63	0.37	FALSE
34	GTEx	Esophagus Mucosa	BTBD7	0.16	0.02	lasso	5	0.05	3.5e-04	3.81	-5.3	1.4e-07	-0.07	0.16	0.25	TRUE
35	GTEx	Esophagus Mucosa	TRIP11	0.09	0.01	lasso	4	0.00	2.4e-01	5.79	5.5	4.5e-08	0.01	0.12	0.29	FALSE
36	GTEx	Esophagus Mucosa	RP11-529H20.6	0.13	0.11	lasso	10	0.13	7.9e-09	6.60	7.1	1.4e-12	0.01	0.10	0.90	FALSE
37	GTEx	Esophagus Muscularis	ATXN3	0.16	0.17	lasso	5	0.17	2.0e-10	6.35	6.6	5.0e-11	0.00	1.00	0.00	FALSE
38	GTEx	Esophagus Muscularis	RIN3	0.17	0.05	lasso	6	0.06	1.6e-04	8.90	-7.6	3.1e-14	-0.47	0.11	0.59	FALSE
39	GTEx	Esophagus Muscularis	TRIP11	0.10	0.11	lasso	4	0.10	8.3e-07	6.35	6.4	1.8e-10	0.01	0.46	0.54	FALSE
40	GTEx	Esophagus Muscularis	RP11-529H20.5	0.17	0.11	enet	19	0.11	2.9e-07	6.35	6.1	9.4e-10	-0.01	0.36	0.63	FALSE
41	GTEx	Esophagus Muscularis	RP11-529H20.6	0.21	0.24	lasso	2	0.22	9.2e-14	6.35	6.3	2.2e-10	0.01	0.65	0.35	FALSE
42	GTEx	Heart Atrial Appendage	RP11-529H20.6	0.27	0.20	lasso	5	0.18	2.5e-08	6.56	6.5	7.6e-11	0.00	0.56	0.44	FALSE
43	GTEx	Heart Left Ventricle	RP11-529H20.5	0.10	0.03	enet	8	0.06	2.7e-04	7.36	6.2	5.1e-10	0.04	0.01	0.97	FALSE
44	GTEx	Heart Left Ventricle	RP11-529H20.6	0.13	0.12	enet	14	0.12	3.4e-07	6.56	6.1	1.4e-09	0.02	0.43	0.56	FALSE
45	GTEx	Lung	RP11-529H20.6	0.08	0.05	enet	15	0.05	1.8e-04	6.56	6.8	1.1e-11	0.00	0.07	0.92	FALSE
46	GTEx	Muscle Skeletal	ATXN3	0.04	0.04	lasso	5	0.04	1.2e-04	6.35	6.5	9.4e-11	0.01	0.78	0.01	FALSE
47	GTEx	Muscle Skeletal	TRIP11	0.05	0.04	lasso	6	0.03	7.9e-04	6.54	6.4	1.3e-10	0.01	0.29	0.57	FALSE
48	GTEx	Muscle Skeletal	RP11-529H20.6	0.11	0.06	lasso	2	0.06	2.9e-06	6.56	6.6	4.7e-11	0.01	0.52	0.48	FALSE
49	GTEx	Nerve Tibial	ATXN3	0.30	0.29	lasso	4	0.29	1.6e-20	6.35	6.5	6.9e-11	0.02	1.00	0.00	FALSE
50	GTEx	Nerve Tibial	TRIP11	0.21	0.14	lasso	6	0.11	3.7e-08	6.35	6.3	4.0e-10	0.01	0.68	0.32	FALSE
51	GTEx	Nerve Tibial	RP11-529H20.5	0.28	0.26	lasso	5	0.25	9.2e-18	6.35	6.3	2.2e-10	0.01	0.68	0.32	FALSE
52	GTEx	Nerve Tibial	RP11-529H20.6	0.29	0.30	lasso	4	0.29	4.4e-21	6.35	6.4	1.3e-10	0.01	0.64	0.36	FALSE
53	GTEx	Ovary	ATXN3	0.32	0.18	lasso	8	0.18	2.9e-05	6.35	6.4	1.2e-10	0.05	0.48	0.04	FALSE
54	GTEx	Ovary	RP11-529H20.5	0.24	0.10	lasso	5	0.11	1.2e-03	6.35	6.2	7.5e-10	0.02	0.04	0.85	FALSE
55	GTEx	Ovary	RP11-529H20.6	0.20	0.23	lasso	4	0.18	4.3e-05	6.56	6.8	8.7e-12	0.01	0.07	0.83	FALSE
56	GTEx	Pituitary	ATXN3	0.33	0.03	lasso	2	0.03	4.7e-02	6.56	6.8	1.4e-11	0.01	0.26	0.09	FALSE
57	GTEx	Pituitary	RP11-529H20.5	0.37	0.14	enet	7	0.07	6.3e-03	7.36	7.1	1.0e-12	0.02	0.01	0.95	FALSE
58	GTEx	Prostate	ATXN3	0.30	0.04	lasso	5	0.06	1.4e-02	6.56	5.8	5.9e-09	0.02	0.09	0.05	FALSE
59	GTEx	Prostate	RP11-529H20.6	0.28	0.00	lasso	5	0.05	2.5e-02	6.56	5.7	9.0e-09	0.04	0.13	0.19	FALSE
60	GTEx	Skin Sun Exposed Lower leg	ATXN3	0.07	0.02	enet	15	0.02	5.8e-03	-3.65	5.8	5.0e-09	0.05	0.19	0.11	FALSE
61	GTEx	Small Intestine Terminal Ileum	RP11-529H20.6	0.36	0.32	lasso	8	0.26	1.8e-06	6.53	6.3	3.4e-10	0.00	0.26	0.68	FALSE
62	GTEx	Spleen	ATXN3	0.27	0.03	lasso	3	0.01	1.5e-01	6.35	5.9	4.0e-09	0.01	0.16	0.07	FALSE
63	GTEx	Spleen	RP11-529H20.5	0.31	0.15	lasso	3	0.18	2.3e-05	7.36	7.5	9.1e-14	0.02	0.01	0.91	TRUE
64	GTEx	Spleen	RP11-529H20.6	0.53	0.22	enet	40	0.32	6.2e-09	6.35	6.1	1.3e-09	0.01	0.28	0.72	FALSE
65	GTEx	Stomach	ATXN3	0.24	0.09	lasso	3	0.11	5.0e-06	6.56	6.6	3.0e-11	0.01	0.98	0.00	FALSE
66	GTEx	Stomach	RP11-529H20.5	0.19	0.12	enet	32	0.12	2.2e-06	6.56	6.0	1.9e-09	0.06	0.19	0.80	FALSE
67	GTEx	Stomach	RP11-529H20.6	0.20	0.27	lasso	4	0.25	2.5e-12	6.35	6.4	1.3e-10	0.01	0.58	0.42	FALSE
68	GTEx	Testis	TRIP11	0.10	0.05	lasso	4	0.02	3.5e-02	6.55	6.5	7.4e-11	0.01	0.09	0.75	FALSE
69	GTEx	Testis	RP11-529H20.5	0.19	0.05	lasso	10	0.05	4.2e-03	6.35	7.1	1.2e-12	0.01	0.04	0.94	FALSE
70	GTEx	Testis	RP11-529H20.6	0.23	0.23	lasso	3	0.22	4.9e-10	6.56	6.7	2.7e-11	0.01	0.52	0.48	FALSE
71	GTEx	Thyroid	ATXN3	0.13	0.05	enet	11	0.14	5.5e-11	6.56	6.4	1.9e-10	0.03	0.86	0.13	FALSE
72	GTEx	Thyroid	TRIP11	0.08	0.04	lasso	4	0.02	6.3e-03	6.53	6.6	3.9e-11	0.02	0.33	0.40	FALSE
73	GTEx	Thyroid	RP11-529H20.5	0.14	0.12	enet	14	0.13	7.7e-10	7.36	6.3	3.6e-10	0.01	0.00	1.00	FALSE
74	GTEx	Thyroid	RP11-529H20.6	0.17	0.18	lasso	2	0.17	9.6e-13	6.56	6.7	2.6e-11	0.01	0.51	0.49	FALSE
75	GTEx	Whole Blood	RP11-529H20.5	0.13	0.09	lasso	5	0.08	1.2e-07	7.36	7.3	4.1e-13	0.03	0.00	1.00	FALSE
76	GTEx	Whole Blood	RP11-529H20.6	0.15	0.13	lasso	4	0.16	3.8e-14	6.56	7.3	3.9e-13	0.02	0.05	0.95	FALSE
77	METSIM	Adipose	GOLGA5	0.07	0.03	blup	539	0.02	1.1e-04	-0.07	-5.9	4.4e-09	-0.26	0.35	0.47	FALSE
78	METSIM	Adipose	TRIP11	0.05	0.04	enet	13	0.02	3.8e-04	7.15	6.2	7.4e-10	0.00	0.01	0.99	FALSE
79	YFS	Blood	ATXN3	0.20	0.14	enet	52	0.24	1.1e-75	6.38	6.1	1.3e-09	0.00	1.00	0.00	FALSE
80	YFS	Blood	TRIP11	0.06	0.04	blup	510	0.04	4.4e-14	6.22	5.3	8.8e-08	0.02	0.67	0.33	FALSE
81	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIP11	0.04	0.01	blup	70	0.01	4.4e-02	-5.54	6.8	1.1e-11	0.00	0.04	0.45	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIP11	0.02	0.02	lasso	1	0.01	1.1e-02	6.49	6.5	8.6e-11	0.01	0.11	0.28	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	RIN3	0.05	0.00	blup	163	0.01	6.0e-02	-3.15	-5.6	2.2e-08	-0.12	0.03	0.04	TRUE
84	The Cancer Genome Atlas	Thyroid Carcinoma	TRIP11	0.08	0.04	blup	70	0.06	3.6e-06	4.97	5.1	2.8e-07	-0.01	0.43	0.53	FALSE
85	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIP11	0.14	0.04	blup	70	0.09	1.6e-03	4.58	6.9	5.6e-12	0.01	0.03	0.56	FALSE