[Hub]/) : Traits : Lung FVC :

chr14:91,738,696-94,495,324

Best TWAS P=4.83e-31 · Best GWAS P=1.3e-30 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ATXN3 0.19 0.17 lasso 5 0.17 1.7e-13 6.35 6.5 7.0e-11 0.01 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous RP11-529H20.5 0.14 0.16 lasso 3 0.15 3.0e-12 6.35 7.0 2.5e-12 0.01 0.45 0.55 FALSE
3 GTEx Adipose Subcutaneous RP11-529H20.6 0.16 0.26 lasso 2 0.26 4.8e-21 6.56 6.6 5.4e-11 0.01 0.42 0.58 FALSE
4 GTEx Adipose Visceral Omentum ATXN3 0.19 0.14 lasso 6 0.12 7.0e-07 6.49 6.5 6.5e-11 0.00 0.99 0.01 FALSE
5 GTEx Adipose Visceral Omentum RP11-529H20.5 0.19 0.05 lasso 6 0.08 9.9e-05 6.60 6.7 1.8e-11 0.02 0.09 0.91 FALSE
6 GTEx Adipose Visceral Omentum RP11-529H20.6 0.26 0.29 lasso 4 0.28 1.1e-14 6.52 6.5 7.9e-11 0.01 0.53 0.47 FALSE
7 GTEx Adrenal Gland RP11-529H20.6 0.22 0.21 lasso 7 0.18 4.8e-07 6.55 6.3 2.7e-10 0.01 0.48 0.48 FALSE
8 GTEx Artery Aorta TRIP11 0.20 0.00 enet 8 0.02 4.0e-02 6.35 5.2 2.5e-07 0.02 0.16 0.22 FALSE
9 GTEx Artery Aorta RP11-529H20.6 0.20 0.14 lasso 4 0.18 6.4e-10 6.56 6.2 7.3e-10 0.02 0.54 0.45 FALSE
10 GTEx Artery Coronary ATXN3 0.21 0.20 lasso 2 0.24 1.4e-08 6.56 7.1 1.1e-12 0.04 0.90 0.01 FALSE
11 GTEx Artery Coronary TRIP11 0.18 0.01 lasso 3 0.00 3.2e-01 5.88 6.1 1.0e-09 0.02 0.09 0.22 FALSE
12 GTEx Artery Tibial ATXN3 0.13 0.11 lasso 3 0.10 5.8e-08 6.22 6.3 2.9e-10 0.00 1.00 0.00 FALSE
13 GTEx Artery Tibial RP11-529H20.5 0.07 0.00 lasso 4 0.00 4.7e-01 7.25 7.1 1.3e-12 0.02 0.02 0.92 FALSE
14 GTEx Artery Tibial RP11-529H20.6 0.20 0.22 lasso 8 0.22 2.3e-17 6.56 6.5 5.9e-11 0.01 0.59 0.41 FALSE
15 GTEx Brain Cerebellum ATXN3 0.26 -0.01 enet 70 0.02 6.3e-02 4.04 6.0 1.6e-09 0.10 0.09 0.10 FALSE
16 GTEx Brain Putamen basal ganglia RP11-529H20.6 0.44 0.14 enet 45 0.26 6.1e-07 7.15 6.5 8.3e-11 0.03 0.02 0.97 FALSE
17 GTEx Breast Mammary Tissue ATXN3 0.20 0.24 lasso 8 0.23 3.5e-12 6.56 6.5 6.5e-11 0.01 1.00 0.00 FALSE
18 GTEx Breast Mammary Tissue RP11-529H20.5 0.22 0.10 enet 23 0.12 1.1e-06 6.49 6.1 1.3e-09 0.03 0.24 0.76 FALSE
19 GTEx Breast Mammary Tissue RP11-529H20.6 0.20 0.23 enet 13 0.27 3.5e-14 6.56 6.5 6.3e-11 0.01 0.53 0.47 FALSE
20 GTEx Breast Mammary Tissue (Female) ATXN3 0.18 0.04 lasso 4 0.03 3.3e-02 6.22 6.4 1.2e-10 0.01 0.47 0.05 FALSE
21 GTEx Breast Mammary Tissue (Female) RP11-529H20.6 0.22 0.13 lasso 3 0.09 1.5e-03 6.49 6.5 8.3e-11 0.01 0.20 0.74 FALSE
22 GTEx Cells EBV-transformed lymphocytes RP11-529H20.6 0.41 0.30 lasso 2 0.28 6.9e-10 6.56 6.3 3.4e-10 0.01 0.57 0.43 FALSE
23 GTEx Cells Transformed fibroblasts ATXN3 0.14 0.10 lasso 9 0.09 6.0e-07 6.35 6.2 4.9e-10 0.00 1.00 0.00 FALSE
24 GTEx Cells Transformed fibroblasts TRIP11 0.09 0.04 lasso 2 0.00 3.8e-01 6.55 6.3 2.5e-10 0.00 0.20 0.18 FALSE
25 GTEx Cells Transformed fibroblasts RP11-529H20.5 0.10 0.13 lasso 11 0.12 3.1e-09 6.37 6.4 1.5e-10 0.01 0.63 0.37 FALSE
26 GTEx Cells Transformed fibroblasts RP11-529H20.6 0.27 0.26 lasso 6 0.24 3.1e-18 6.56 6.7 2.7e-11 0.01 0.57 0.43 FALSE
27 GTEx Colon Sigmoid ATXN3 0.31 0.30 lasso 2 0.33 3.4e-12 6.56 6.4 1.4e-10 0.01 1.00 0.00 FALSE
28 GTEx Colon Sigmoid RIN3 0.24 0.17 lasso 6 0.11 9.3e-05 11.36 -11.6 4.8e-31 -0.97 0.00 0.99 TRUE
29 GTEx Colon Sigmoid RP11-529H20.5 0.27 0.05 lasso 8 0.04 1.9e-02 5.87 6.1 8.3e-10 0.02 0.14 0.70 FALSE
30 GTEx Colon Sigmoid RP11-529H20.6 0.24 0.24 lasso 3 0.27 4.8e-10 6.56 6.6 5.4e-11 0.01 0.57 0.43 FALSE
31 GTEx Colon Transverse RP11-529H20.6 0.18 0.14 lasso 5 0.18 3.7e-09 6.56 6.6 4.7e-11 0.03 0.57 0.43 FALSE
32 GTEx Esophagus Gastroesophageal Junction TRIP11 0.16 0.13 lasso 11 0.12 3.7e-05 6.12 5.4 5.5e-08 -0.02 0.39 0.40 FALSE
33 GTEx Esophagus Gastroesophageal Junction RP11-529H20.6 0.26 0.27 enet 26 0.26 6.2e-10 6.35 5.8 6.1e-09 0.00 0.63 0.37 FALSE
34 GTEx Esophagus Mucosa BTBD7 0.16 0.02 lasso 5 0.05 3.5e-04 3.81 -5.3 1.4e-07 -0.07 0.16 0.25 TRUE
35 GTEx Esophagus Mucosa TRIP11 0.09 0.01 lasso 4 0.00 2.4e-01 5.79 5.5 4.5e-08 0.01 0.12 0.29 FALSE
36 GTEx Esophagus Mucosa RP11-529H20.6 0.13 0.11 lasso 10 0.13 7.9e-09 6.60 7.1 1.4e-12 0.01 0.10 0.90 FALSE
37 GTEx Esophagus Muscularis ATXN3 0.16 0.17 lasso 5 0.17 2.0e-10 6.35 6.6 5.0e-11 0.00 1.00 0.00 FALSE
38 GTEx Esophagus Muscularis RIN3 0.17 0.05 lasso 6 0.06 1.6e-04 8.90 -7.6 3.1e-14 -0.47 0.11 0.59 FALSE
39 GTEx Esophagus Muscularis TRIP11 0.10 0.11 lasso 4 0.10 8.3e-07 6.35 6.4 1.8e-10 0.01 0.46 0.54 FALSE
40 GTEx Esophagus Muscularis RP11-529H20.5 0.17 0.11 enet 19 0.11 2.9e-07 6.35 6.1 9.4e-10 -0.01 0.36 0.63 FALSE
41 GTEx Esophagus Muscularis RP11-529H20.6 0.21 0.24 lasso 2 0.22 9.2e-14 6.35 6.3 2.2e-10 0.01 0.65 0.35 FALSE
42 GTEx Heart Atrial Appendage RP11-529H20.6 0.27 0.20 lasso 5 0.18 2.5e-08 6.56 6.5 7.6e-11 0.00 0.56 0.44 FALSE
43 GTEx Heart Left Ventricle RP11-529H20.5 0.10 0.03 enet 8 0.06 2.7e-04 7.36 6.2 5.1e-10 0.04 0.01 0.97 FALSE
44 GTEx Heart Left Ventricle RP11-529H20.6 0.13 0.12 enet 14 0.12 3.4e-07 6.56 6.1 1.4e-09 0.02 0.43 0.56 FALSE
45 GTEx Lung RP11-529H20.6 0.08 0.05 enet 15 0.05 1.8e-04 6.56 6.8 1.1e-11 0.00 0.07 0.92 FALSE
46 GTEx Muscle Skeletal ATXN3 0.04 0.04 lasso 5 0.04 1.2e-04 6.35 6.5 9.4e-11 0.01 0.78 0.01 FALSE
47 GTEx Muscle Skeletal TRIP11 0.05 0.04 lasso 6 0.03 7.9e-04 6.54 6.4 1.3e-10 0.01 0.29 0.57 FALSE
48 GTEx Muscle Skeletal RP11-529H20.6 0.11 0.06 lasso 2 0.06 2.9e-06 6.56 6.6 4.7e-11 0.01 0.52 0.48 FALSE
49 GTEx Nerve Tibial ATXN3 0.30 0.29 lasso 4 0.29 1.6e-20 6.35 6.5 6.9e-11 0.02 1.00 0.00 FALSE
50 GTEx Nerve Tibial TRIP11 0.21 0.14 lasso 6 0.11 3.7e-08 6.35 6.3 4.0e-10 0.01 0.68 0.32 FALSE
51 GTEx Nerve Tibial RP11-529H20.5 0.28 0.26 lasso 5 0.25 9.2e-18 6.35 6.3 2.2e-10 0.01 0.68 0.32 FALSE
52 GTEx Nerve Tibial RP11-529H20.6 0.29 0.30 lasso 4 0.29 4.4e-21 6.35 6.4 1.3e-10 0.01 0.64 0.36 FALSE
53 GTEx Ovary ATXN3 0.32 0.18 lasso 8 0.18 2.9e-05 6.35 6.4 1.2e-10 0.05 0.48 0.04 FALSE
54 GTEx Ovary RP11-529H20.5 0.24 0.10 lasso 5 0.11 1.2e-03 6.35 6.2 7.5e-10 0.02 0.04 0.85 FALSE
55 GTEx Ovary RP11-529H20.6 0.20 0.23 lasso 4 0.18 4.3e-05 6.56 6.8 8.7e-12 0.01 0.07 0.83 FALSE
56 GTEx Pituitary ATXN3 0.33 0.03 lasso 2 0.03 4.7e-02 6.56 6.8 1.4e-11 0.01 0.26 0.09 FALSE
57 GTEx Pituitary RP11-529H20.5 0.37 0.14 enet 7 0.07 6.3e-03 7.36 7.1 1.0e-12 0.02 0.01 0.95 FALSE
58 GTEx Prostate ATXN3 0.30 0.04 lasso 5 0.06 1.4e-02 6.56 5.8 5.9e-09 0.02 0.09 0.05 FALSE
59 GTEx Prostate RP11-529H20.6 0.28 0.00 lasso 5 0.05 2.5e-02 6.56 5.7 9.0e-09 0.04 0.13 0.19 FALSE
60 GTEx Skin Sun Exposed Lower leg ATXN3 0.07 0.02 enet 15 0.02 5.8e-03 -3.65 5.8 5.0e-09 0.05 0.19 0.11 FALSE
61 GTEx Small Intestine Terminal Ileum RP11-529H20.6 0.36 0.32 lasso 8 0.26 1.8e-06 6.53 6.3 3.4e-10 0.00 0.26 0.68 FALSE
62 GTEx Spleen ATXN3 0.27 0.03 lasso 3 0.01 1.5e-01 6.35 5.9 4.0e-09 0.01 0.16 0.07 FALSE
63 GTEx Spleen RP11-529H20.5 0.31 0.15 lasso 3 0.18 2.3e-05 7.36 7.5 9.1e-14 0.02 0.01 0.91 TRUE
64 GTEx Spleen RP11-529H20.6 0.53 0.22 enet 40 0.32 6.2e-09 6.35 6.1 1.3e-09 0.01 0.28 0.72 FALSE
65 GTEx Stomach ATXN3 0.24 0.09 lasso 3 0.11 5.0e-06 6.56 6.6 3.0e-11 0.01 0.98 0.00 FALSE
66 GTEx Stomach RP11-529H20.5 0.19 0.12 enet 32 0.12 2.2e-06 6.56 6.0 1.9e-09 0.06 0.19 0.80 FALSE
67 GTEx Stomach RP11-529H20.6 0.20 0.27 lasso 4 0.25 2.5e-12 6.35 6.4 1.3e-10 0.01 0.58 0.42 FALSE
68 GTEx Testis TRIP11 0.10 0.05 lasso 4 0.02 3.5e-02 6.55 6.5 7.4e-11 0.01 0.09 0.75 FALSE
69 GTEx Testis RP11-529H20.5 0.19 0.05 lasso 10 0.05 4.2e-03 6.35 7.1 1.2e-12 0.01 0.04 0.94 FALSE
70 GTEx Testis RP11-529H20.6 0.23 0.23 lasso 3 0.22 4.9e-10 6.56 6.7 2.7e-11 0.01 0.52 0.48 FALSE
71 GTEx Thyroid ATXN3 0.13 0.05 enet 11 0.14 5.5e-11 6.56 6.4 1.9e-10 0.03 0.86 0.13 FALSE
72 GTEx Thyroid TRIP11 0.08 0.04 lasso 4 0.02 6.3e-03 6.53 6.6 3.9e-11 0.02 0.33 0.40 FALSE
73 GTEx Thyroid RP11-529H20.5 0.14 0.12 enet 14 0.13 7.7e-10 7.36 6.3 3.6e-10 0.01 0.00 1.00 FALSE
74 GTEx Thyroid RP11-529H20.6 0.17 0.18 lasso 2 0.17 9.6e-13 6.56 6.7 2.6e-11 0.01 0.51 0.49 FALSE
75 GTEx Whole Blood RP11-529H20.5 0.13 0.09 lasso 5 0.08 1.2e-07 7.36 7.3 4.1e-13 0.03 0.00 1.00 FALSE
76 GTEx Whole Blood RP11-529H20.6 0.15 0.13 lasso 4 0.16 3.8e-14 6.56 7.3 3.9e-13 0.02 0.05 0.95 FALSE
77 METSIM Adipose GOLGA5 0.07 0.03 blup 539 0.02 1.1e-04 -0.07 -5.9 4.4e-09 -0.26 0.35 0.47 FALSE
78 METSIM Adipose TRIP11 0.05 0.04 enet 13 0.02 3.8e-04 7.15 6.2 7.4e-10 0.00 0.01 0.99 FALSE
79 YFS Blood ATXN3 0.20 0.14 enet 52 0.24 1.1e-75 6.38 6.1 1.3e-09 0.00 1.00 0.00 FALSE
80 YFS Blood TRIP11 0.06 0.04 blup 510 0.04 4.4e-14 6.22 5.3 8.8e-08 0.02 0.67 0.33 FALSE
81 The Cancer Genome Atlas Colon Adenocarcinoma TRIP11 0.04 0.01 blup 70 0.01 4.4e-02 -5.54 6.8 1.1e-11 0.00 0.04 0.45 FALSE
82 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TRIP11 0.02 0.02 lasso 1 0.01 1.1e-02 6.49 6.5 8.6e-11 0.01 0.11 0.28 FALSE
83 The Cancer Genome Atlas Lung Adenocarcinoma RIN3 0.05 0.00 blup 163 0.01 6.0e-02 -3.15 -5.6 2.2e-08 -0.12 0.03 0.04 TRUE
84 The Cancer Genome Atlas Thyroid Carcinoma TRIP11 0.08 0.04 blup 70 0.06 3.6e-06 4.97 5.1 2.8e-07 -0.01 0.43 0.53 FALSE
85 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma TRIP11 0.14 0.04 blup 70 0.09 1.6e-03 4.58 6.9 5.6e-12 0.01 0.03 0.56 FALSE