Best TWAS P=5.68e-15 · Best GWAS P=1.78e-15 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EXD1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 8.1e-06 | 6.4 | -6.0 | 1.6e-09 | -0.03 | 0.08 | 0.92 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PAK6 | 0.16 | 0.02 | bslmm | 435 | 0.05 | 4.0e-07 | -1.5 | -5.3 | 1.3e-07 | 0.15 | 0.26 | 0.49 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | EIF2AK4 | 0.38 | 0.08 | enet | 18 | 0.23 | 4.7e-19 | 3.9 | 5.4 | 6.4e-08 | -0.09 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | SPTBN5 | 0.35 | 0.23 | enet | 32 | 0.31 | 3.3e-26 | 4.4 | -5.1 | 3.1e-07 | -0.01 | 0.08 | 0.88 | FALSE |
| 5 | GTEx | Adipose Visceral Omentum | EIF2AK4 | 0.23 | 0.08 | lasso | 7 | 0.15 | 2.7e-08 | 2.2 | 5.9 | 4.3e-09 | -0.14 | 0.52 | 0.10 | TRUE |
| 6 | GTEx | Adrenal Gland | LTK | 0.21 | 0.05 | enet | 21 | 0.06 | 3.9e-03 | 3.9 | -6.0 | 1.6e-09 | 0.00 | 0.18 | 0.13 | FALSE |
| 7 | GTEx | Artery Aorta | EIF2AK4 | 0.31 | 0.08 | enet | 29 | 0.17 | 1.8e-09 | -4.7 | 6.9 | 6.7e-12 | -0.16 | 0.94 | 0.01 | TRUE |
| 8 | GTEx | Brain Cortex | GCHFR | 0.25 | 0.04 | enet | 15 | 0.05 | 1.4e-02 | 6.6 | -6.3 | 2.3e-10 | 0.08 | 0.05 | 0.58 | TRUE |
| 9 | GTEx | Esophagus Mucosa | CHP1 | 0.19 | 0.10 | lasso | 7 | 0.09 | 1.4e-06 | 6.7 | -6.1 | 9.4e-10 | -0.02 | 0.03 | 0.97 | FALSE |
| 10 | GTEx | Esophagus Muscularis | RP11-64K12.8 | 0.10 | 0.00 | enet | 13 | 0.00 | 4.6e-01 | -1.7 | -6.7 | 2.6e-11 | 0.05 | 0.05 | 0.05 | TRUE |
| 11 | GTEx | Lung | OIP5-AS1 | 0.09 | 0.08 | enet | 14 | 0.12 | 2.8e-09 | 6.7 | 5.3 | 1.0e-07 | 0.02 | 0.05 | 0.95 | FALSE |
| 12 | GTEx | Muscle Skeletal | IVD | 0.32 | 0.24 | lasso | 9 | 0.27 | 1.9e-26 | 6.8 | -5.7 | 1.2e-08 | -0.05 | 0.88 | 0.12 | FALSE |
| 13 | GTEx | Muscle Skeletal | RP11-23P13.7 | 0.07 | 0.02 | lasso | 4 | 0.04 | 1.3e-04 | 4.4 | -5.5 | 2.9e-08 | 0.05 | 0.03 | 0.93 | TRUE |
| 14 | GTEx | Skin Sun Exposed Lower leg | CHP1 | 0.06 | 0.04 | enet | 9 | 0.04 | 3.1e-04 | 6.7 | -5.7 | 1.2e-08 | -0.02 | 0.03 | 0.94 | FALSE |
| 15 | METSIM | Adipose | BMF | 0.04 | 0.00 | enet | 10 | 0.01 | 2.9e-03 | -8.0 | -6.4 | 1.2e-10 | 0.64 | 0.00 | 0.95 | TRUE |
| 16 | METSIM | Adipose | DISP2 | 0.38 | 0.22 | bslmm | 397 | 0.29 | 2.9e-43 | -5.8 | -5.6 | 2.6e-08 | 0.01 | 0.98 | 0.02 | FALSE |
| 17 | METSIM | Adipose | EIF2AK4 | 0.24 | 0.04 | enet | 25 | 0.17 | 1.1e-24 | 3.9 | 6.3 | 3.6e-10 | -0.08 | 1.00 | 0.00 | FALSE |
| 18 | METSIM | Adipose | SRP14 | 0.13 | 0.05 | bslmm | 445 | 0.08 | 1.3e-11 | -2.1 | -5.4 | 7.5e-08 | 0.11 | 1.00 | 0.00 | FALSE |
| 19 | NTR | Blood | INO80 | 0.02 | 0.02 | enet | 8 | 0.03 | 2.8e-09 | 6.2 | -6.2 | 5.4e-10 | 0.03 | 0.08 | 0.92 | FALSE |
| 20 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DISP2 | 0.28 | 0.08 | enet | 13 | 0.18 | 9.0e-15 | -6.8 | -5.3 | 1.3e-07 | -0.04 | 0.01 | 0.99 | TRUE |
| 21 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHP | 0.01 | 0.01 | blup | 54 | 0.01 | 1.4e-02 | 6.7 | -6.2 | 4.7e-10 | 0.00 | 0.01 | 0.87 | FALSE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DISP2 | 0.31 | 0.22 | lasso | 8 | 0.31 | 3.7e-64 | -6.8 | -6.8 | 1.2e-11 | -0.02 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DISP2 | 0.16 | 0.03 | blup | 50 | 0.10 | 1.6e-05 | -5.8 | -5.5 | 2.9e-08 | 0.03 | 0.03 | 0.81 | FALSE |
| 24 | The Cancer Genome Atlas | Colon Adenocarcinoma | DISP2 | 0.14 | 0.10 | blup | 50 | 0.14 | 1.9e-08 | 5.8 | -5.7 | 9.5e-09 | 0.00 | 0.03 | 0.96 | TRUE |
| 25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DISP2 | 0.22 | 0.11 | lasso | 9 | 0.18 | 5.1e-20 | -5.8 | -6.0 | 1.9e-09 | 0.00 | 0.02 | 0.98 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DISP2 | 0.43 | 0.20 | enet | 20 | 0.40 | 2.1e-48 | -5.8 | -6.0 | 1.6e-09 | 0.00 | 0.07 | 0.93 | FALSE |
| 27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EIF2AK4 | 0.12 | 0.06 | enet | 5 | 0.09 | 2.4e-10 | -4.7 | 5.4 | 7.2e-08 | -0.11 | 0.09 | 0.90 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DISP2 | 0.39 | 0.24 | enet | 11 | 0.34 | 5.0e-20 | -6.8 | -7.8 | 5.7e-15 | -0.03 | 0.01 | 0.99 | TRUE |
| 29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | INO80 | 0.03 | 0.02 | blup | 38 | 0.03 | 1.1e-02 | 3.1 | 5.6 | 2.6e-08 | -0.03 | 0.03 | 0.46 | FALSE |
| 30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DISP2 | 0.17 | 0.10 | enet | 16 | 0.15 | 9.9e-17 | -5.8 | -5.7 | 1.4e-08 | 0.01 | 0.02 | 0.98 | TRUE |
| 31 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DISP2 | 0.37 | 0.18 | enet | 9 | 0.21 | 2.4e-10 | -5.8 | -6.2 | 6.3e-10 | -0.02 | 0.05 | 0.95 | TRUE |
| 32 | The Cancer Genome Atlas | Lung Adenocarcinoma | DISP2 | 0.30 | 0.15 | lasso | 5 | 0.28 | 2.7e-32 | -6.8 | -6.7 | 2.8e-11 | -0.01 | 0.01 | 0.99 | FALSE |
| 33 | The Cancer Genome Atlas | Lung Adenocarcinoma | EIF2AK4 | 0.09 | 0.02 | enet | 10 | 0.04 | 8.2e-06 | 3.9 | 5.8 | 5.2e-09 | -0.11 | 0.01 | 0.97 | FALSE |
| 34 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DISP2 | 0.21 | 0.12 | enet | 10 | 0.17 | 1.7e-18 | -5.8 | -5.7 | 9.2e-09 | -0.02 | 0.09 | 0.91 | FALSE |
| 35 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DISP2 | 0.31 | 0.23 | enet | 5 | 0.28 | 2.8e-19 | -6.8 | -7.0 | 3.0e-12 | -0.02 | 0.01 | 0.99 | FALSE |
| 36 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DISP2 | 0.30 | 0.14 | enet | 10 | 0.18 | 3.7e-08 | 6.5 | -6.2 | 6.7e-10 | -0.03 | 0.02 | 0.97 | FALSE |
| 37 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | INO80 | 0.07 | 0.04 | blup | 40 | 0.06 | 1.2e-03 | 3.1 | 5.7 | 1.3e-08 | -0.02 | 0.02 | 0.77 | FALSE |
| 38 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHP | 0.21 | 0.11 | lasso | 4 | 0.12 | 5.1e-13 | 4.5 | -6.3 | 3.4e-10 | -0.01 | 0.27 | 0.73 | TRUE |
| 39 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DISP2 | 0.45 | 0.40 | lasso | 8 | 0.45 | 3.1e-52 | -6.8 | -6.8 | 1.4e-11 | -0.02 | 0.01 | 0.99 | FALSE |
| 40 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EIF2AK4 | 0.07 | 0.02 | enet | 5 | 0.02 | 5.4e-03 | -4.7 | 5.8 | 8.5e-09 | -0.09 | 0.05 | 0.60 | FALSE |
| 41 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FSIP1 | 0.06 | 0.02 | blup | 138 | 0.04 | 2.7e-05 | 4.8 | 5.2 | 2.0e-07 | -0.01 | 0.62 | 0.32 | TRUE |
| 42 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DISP2 | 0.35 | 0.14 | enet | 13 | 0.28 | 3.5e-17 | -5.8 | -5.5 | 2.9e-08 | -0.02 | 0.11 | 0.89 | FALSE |
| 43 | The Cancer Genome Atlas | Stomach Adenocarcinoma | DISP2 | 0.10 | 0.05 | lasso | 4 | 0.07 | 4.4e-06 | 5.8 | -7.0 | 3.4e-12 | -0.02 | 0.13 | 0.84 | FALSE |
| 44 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DISP2 | 0.37 | 0.26 | lasso | 4 | 0.28 | 2.4e-10 | -6.8 | -7.6 | 4.3e-14 | -0.01 | 0.01 | 0.99 | FALSE |
| 45 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | EXD1 | 0.33 | 0.04 | enet | 12 | 0.12 | 6.1e-05 | 5.4 | 5.8 | 5.8e-09 | 0.06 | 0.02 | 0.69 | FALSE |
| 46 | The Cancer Genome Atlas | Thyroid Carcinoma | DISP2 | 0.35 | 0.25 | enet | 17 | 0.32 | 3.0e-31 | -5.8 | -5.6 | 2.0e-08 | 0.03 | 0.40 | 0.60 | FALSE |
| 47 | The Cancer Genome Atlas | Thyroid Carcinoma | INO80 | 0.03 | 0.02 | blup | 39 | 0.03 | 1.0e-03 | 4.0 | 5.6 | 2.1e-08 | -0.02 | 0.02 | 0.94 | FALSE |
| 48 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | DISP2 | 0.35 | 0.08 | enet | 5 | 0.09 | 1.8e-03 | 5.3 | -6.3 | 3.4e-10 | 0.00 | 0.02 | 0.49 | FALSE |