Best TWAS P=6.35e-20 · Best GWAS P=8.88e-30 conditioned to 6.66e-18
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | HLA-AS1 | 0.12 | 0.03 | enet | 13 | 0.05 | 3.9e-05 | -4.1 | 7.0 | 2.5e-12 | 0.20 | 0.57 | 0.08 | FALSE |
| 2 | GTEx | Brain Cerebellum | HLX | 0.29 | 0.12 | lasso | 3 | 0.23 | 1.7e-07 | 5.7 | -5.2 | 2.3e-07 | -0.04 | 0.31 | 0.04 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | HLX | 0.06 | 0.00 | enet | 9 | 0.00 | 5.3e-01 | 1.9 | 9.1 | 6.4e-20 | 0.28 | 0.07 | 0.22 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | HLA-AS1 | 0.10 | 0.03 | lasso | 7 | 0.04 | 8.9e-04 | -4.1 | 7.9 | 2.0e-15 | 0.27 | 0.16 | 0.46 | FALSE |
| 5 | GTEx | Heart Left Ventricle | MARC2 | 0.19 | 0.12 | lasso | 2 | 0.08 | 4.4e-05 | -5.3 | -5.2 | 1.6e-07 | -0.10 | 0.43 | 0.02 | FALSE |
| 6 | GTEx | Heart Left Ventricle | C1orf115 | 0.22 | 0.16 | lasso | 6 | 0.14 | 5.0e-08 | -5.6 | -5.4 | 5.7e-08 | -0.10 | 0.99 | 0.00 | TRUE |
| 7 | GTEx | Heart Left Ventricle | MARC1 | 0.44 | 0.34 | lasso | 1 | 0.35 | 1.5e-19 | -5.3 | -5.3 | 1.4e-07 | -0.11 | 1.00 | 0.00 | FALSE |