[Hub]/) : Traits : Lung FVC :

chr1:220,171,786-221,753,645

Best TWAS P=6.35e-20 · Best GWAS P=8.88e-30 conditioned to 6.66e-18

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial HLA-AS1 0.12 0.03 enet 13 0.05 3.9e-05 -4.1 7.0 2.5e-12 0.20 0.57 0.08 FALSE
2 GTEx Brain Cerebellum HLX 0.29 0.12 lasso 3 0.23 1.7e-07 5.7 -5.2 2.3e-07 -0.04 0.31 0.04 FALSE
3 GTEx Cells Transformed fibroblasts HLX 0.06 0.00 enet 9 0.00 5.3e-01 1.9 9.1 6.4e-20 0.28 0.07 0.22 TRUE
4 GTEx Cells Transformed fibroblasts HLA-AS1 0.10 0.03 lasso 7 0.04 8.9e-04 -4.1 7.9 2.0e-15 0.27 0.16 0.46 FALSE
5 GTEx Heart Left Ventricle MARC2 0.19 0.12 lasso 2 0.08 4.4e-05 -5.3 -5.2 1.6e-07 -0.10 0.43 0.02 FALSE
6 GTEx Heart Left Ventricle C1orf115 0.22 0.16 lasso 6 0.14 5.0e-08 -5.6 -5.4 5.7e-08 -0.10 0.99 0.00 TRUE
7 GTEx Heart Left Ventricle MARC1 0.44 0.34 lasso 1 0.35 1.5e-19 -5.3 -5.3 1.4e-07 -0.11 1.00 0.00 FALSE