Best TWAS P=1.92e-09 · Best GWAS P=2.98e-07 conditioned to 0.207
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NDUFA2 | 0.02 | 0.01 | bslmm | 343 | 0.01 | 7.8e-03 | -4.4 | 5.1 | 2.8e-07 | 0.73 | 0.09 | 0.55 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | ZMAT2 | 0.06 | 0.10 | blup | 360 | 0.09 | 1.4e-11 | -4.4 | -5.6 | 2.1e-08 | -0.67 | 0.14 | 0.83 | FALSE |
3 | GTEx | Adipose Visceral Omentum | TMCO6 | 0.06 | 0.01 | enet | 7 | 0.03 | 1.3e-02 | -4.7 | -5.4 | 8.3e-08 | -0.47 | 0.06 | 0.79 | FALSE |
4 | GTEx | Artery Tibial | SRA1 | 0.07 | 0.02 | lasso | 10 | 0.02 | 7.8e-03 | -4.7 | -5.3 | 1.1e-07 | -0.44 | 0.09 | 0.55 | FALSE |
5 | GTEx | Brain Cerebellum | TMCO6 | 0.23 | 0.18 | enet | 14 | 0.22 | 3.3e-07 | -4.4 | -5.6 | 2.3e-08 | -0.62 | 0.07 | 0.91 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | PFDN1 | 0.24 | 0.04 | lasso | 9 | 0.09 | 4.0e-03 | -4.8 | 5.6 | 1.6e-08 | 0.37 | 0.05 | 0.66 | FALSE |
7 | GTEx | Breast Mammary Tissue (Male) | TMCO6 | 0.12 | -0.01 | lasso | 2 | -0.01 | 4.9e-01 | -4.7 | -5.2 | 2.3e-07 | -0.37 | 0.03 | 0.20 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | TMCO6 | 0.11 | 0.11 | lasso | 6 | 0.11 | 1.8e-08 | -4.8 | -5.4 | 6.0e-08 | -0.54 | 0.04 | 0.95 | FALSE |
9 | GTEx | Esophagus Mucosa | TMCO6 | 0.04 | 0.02 | lasso | 4 | 0.01 | 6.1e-02 | -4.8 | -5.8 | 5.1e-09 | -0.67 | 0.08 | 0.69 | FALSE |
10 | GTEx | Lung | TMCO6 | 0.06 | 0.03 | lasso | 3 | 0.03 | 1.1e-03 | -4.4 | -5.2 | 2.6e-07 | -0.49 | 0.09 | 0.86 | FALSE |
11 | GTEx | Skin Sun Exposed Lower leg | SRA1 | 0.05 | 0.04 | lasso | 3 | 0.06 | 1.0e-05 | -4.6 | -5.4 | 6.7e-08 | -0.51 | 0.07 | 0.88 | FALSE |
12 | METSIM | Adipose | TMCO6 | 0.10 | 0.08 | lasso | 8 | 0.11 | 7.0e-16 | -4.5 | -5.1 | 2.8e-07 | -0.42 | 0.04 | 0.95 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | ZMAT2 | 0.03 | 0.02 | bslmm | 185 | 0.02 | 6.5e-04 | -4.5 | -6.0 | 1.9e-09 | -0.70 | 0.08 | 0.87 | TRUE |
14 | YFS | Blood | APBB3 | 0.01 | 0.00 | bslmm | 318 | 0.00 | 2.7e-02 | -4.7 | 6.0 | 2.3e-09 | 0.65 | 0.07 | 0.60 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PCDHA13 | 0.07 | 0.06 | blup | 29 | 0.09 | 8.6e-11 | 4.3 | 5.2 | 2.4e-07 | 0.90 | 0.02 | 0.95 | FALSE |
16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | NDUFA2 | 0.10 | 0.04 | blup | 43 | 0.06 | 1.4e-03 | -4.4 | 5.1 | 3.1e-07 | 0.55 | 0.02 | 0.75 | FALSE |