TWAS hub - APBB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.0650	0.0350	0.0076	-0.003	NA	-0.006	NA	-0.006	0.450	NA	0.710	NA	0.820
2	ROSMAP	Brain Pre-frontal Cortex	0.0366	0.0178	0.0014	0.006	0.012	0.002	0.011	0.003	0.056	0.0097	0.160	0.014	0.130
3	YFS	Blood	0.0079	0.0049	0.0095	0.003	0.003	0.002	0.003	0.002	0.032	0.0360	0.082	0.027	0.042

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Friendships satisfaction	8.6	10.7	17.4	-3.0	2.4	4.2
Intelligence (Savage-Jansen 2018)	7.7	23.7	39.4	-5.0	2.6	6.3
Ever unenthusiastic/disinterested for a whole week	7.4	9.1	21.3	-1.7	1.7	4.6
Worry too long after embarrassment	6.9	11.5	20.8	-4.6	2.6	2.7
Verbal and Numeric Reasoning (VNR)	6.7	16.1	23.1	-4.6	1.9	4.8
Bipolar Disorder or Schizophrenia	6.2	15.0	30.0	3.5	-1.6	-5.5
Neuroticism score	5.4	11.3	18.0	-4.2	2.9	2.7
Bipolar Disorder (2011)	5.3	5.1	6.5	1.9	-2.3	-2.5
Bipolar Disorder (2018)	5.1	8.0	12.2	3.5	-2.4	-2.5
Neuroticism (2016)	5.0	7.2	9.7	-2.4	3.1	2.5
Neuroticism	5.0	12.0	17.7	-4.2	2.4	3.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.7	10.0	24.2	-1.8	1.6	4.9
Depression (Nagel 2018)	4.6	6.9	11.5	-3.4	1.1	2.8
Financial situation satisfaction	4.6	5.7	7.2	-2.5	1.8	2.7
Schizophrenia (2018)	4.5	9.4	25.3	1.7	-0.1	-5.0
Respiratory disease	4.3	9.6	16.4	-4.1	-0.6	3.5
Chest pain or discomfort	4.2	6.0	8.1	-2.8	2.0	2.5
Fed-up feelings	4.1	7.5	8.8	-3.0	2.8	2.4
Mean time to correctly identify matches	4.1	7.8	15.1	-3.9	2.3	1.7
Ever taken oral contraceptive pill	4.0	4.4	8.9	-2.0	3.0	0.5
Family relationship satisfaction	3.8	4.6	8.3	-1.6	1.8	2.9
Lung FVC	3.7	18.9	35.7	-3.5	3.0	6.0
Frequency of depressed mood in last 2 weeks	3.6	5.1	8.0	-2.8	1.6	2.2
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	8.2	-2.9	2.3	1.8
Systolic Blood Pressure	3.5	17.4	33.7	3.4	-2.6	-5.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.4	8.3	-2.9	2.1	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.5	11.2	-3.3	0.3	1.5
Neuroticism (Nagel 2018)	3.4	7.9	11.5	-3.4	2.1	2.8
Asthma (self-reported)	3.4	6.7	11.3	-2.7	-1.1	3.4
Wheeze or whistling in the chest in last year	3.3	6.0	11.6	-3.4	1.3	2.1
Miserableness	3.3	5.7	8.3	-2.9	1.3	2.6
Depressed Affect (Nagel 2018)	3.1	6.5	10.1	-3.2	1.5	2.7
Schizophrenia (2014)	3.1	6.7	18.8	1.0	-0.7	-4.3
Asthma	3.0	5.9	9.4	-2.7	-1.0	3.1
Commuting to job workplace: Public transport	3.0	3.6	6.8	-1.3	2.6	1.5
Reaction Time	2.9	5.6	11.6	-3.4	1.7	1.5
Fluid intelligence score	2.9	6.1	8.9	-2.3	1.9	3.0
Eye problems/disorders: None of the above	2.9	3.3	6.4	1.2	1.4	-2.5
Hearing difficulty/problems: Yes	2.7	4.1	7.5	-2.7	1.6	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.7	8.7	25.2	-0.9	-0.4	5.0
Tense / ‘highly strung’	2.7	4.5	7.0	-2.6	2.3	1.1
Medication: Simvastatin	2.6	3.8	9.9	-1.2	3.1	-0.4
Falls in the last year	2.6	3.5	5.1	-1.7	2.2	1.6
Mouth/teeth dental problems: Bleeding gums	2.6	3.3	5.6	2.0	0.5	-2.4
Alcohol drinker status: Never	2.6	3.1	8.2	1.0	-0.5	-2.9
Ever smoked	2.6	4.6	8.2	-2.2	0.8	2.9
Financial difficulties in last 2 years	2.5	3.4	4.8	-1.9	1.4	2.2
Length of working week for main job	2.5	2.7	5.6	-1.6	0.1	2.4
Loneliness, isolation	2.5	3.4	4.9	-2.0	2.2	1.1
Ever depressed for a whole week	2.5	3.1	5.4	-1.5	1.3	2.3
Supplements: Glucosamine	2.4	3.2	4.5	1.4	2.1	-1.7
Frequency of tiredness / lethargy in last 2 weeks	2.4	4.0	6.0	-2.4	0.0	2.5
Mouth/teeth dental problems: Loose teeth	2.4	2.9	8.6	-0.1	2.9	-0.3
Medication: Amlodipine	2.3	3.2	5.4	2.3	-0.4	-2.0
Shortness of breath walking on level ground	2.3	2.8	5.1	-2.3	-0.3	1.8
Emphysema/chronic bronchitis	2.3	2.6	4.3	-2.1	1.1	1.5
Average weekly spirits intake	2.2	2.8	6.3	-2.5	0.2	1.4
Worrier / anxious feelings	2.2	4.2	6.9	-2.3	2.6	0.5
Forced vital capacity (FVC), Best measure	2.2	8.0	23.3	-0.6	-0.5	4.8
Number of full sisters	2.2	2.6	4.8	-2.2	0.8	1.6
Impedance of leg (left)	2.1	10.1	11.5	2.9	-3.2	-3.4
Happiness	2.1	2.5	4.5	-1.4	1.1	2.1
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.4	-1.5	2.3	-0.1
Impedance of whole body	2.1	10.5	12.2	3.5	-2.7	-3.5
Impedance of leg (right)	2.0	9.5	11.2	2.6	-3.2	-3.4
Medication: Cholesterol lowering	2.0	3.1	6.6	-1.6	2.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	9.3	1.7	-3.1	0.5
Medication: Paracetamol	2.0	3.1	5.6	1.9	0.3	-2.4
Alzheimer’s Disease (including proxy)	1.9	2.7	4.1	1.2	2.0	-1.6
Townsend deprivation index at recruitment	1.9	2.7	6.3	-1.0	2.5	0.9
Past tobacco smoking	1.9	3.5	5.3	1.5	-1.7	-2.3
Headache pain in last month	1.9	3.2	5.9	1.0	-2.4	-1.7
Heart disease (mother)	1.9	2.3	6.0	-2.4	-0.1	1.0
Long-standing illness, disability or infirmity	1.9	2.9	7.0	-2.7	0.1	1.3
Average weekly champagne plus white wine intake	1.9	2.6	5.5	2.3	0.1	-1.5
Guilty feelings	1.9	2.8	3.8	-1.8	1.9	1.3
Wears glasses or contact lenses	1.9	2.2	6.2	0.6	-0.0	2.5
Heart disease (siblings)	1.9	2.3	5.7	-2.4	0.1	1.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	4.2	-1.7	0.1	2.0
Medication: Atenolol	1.8	2.2	2.6	1.3	-1.6	-1.6
Hearing difficulty/problems with background noise	1.8	2.8	3.5	-1.3	1.8	1.9
Lung cancer (father)	1.8	2.1	5.4	0.1	-1.0	-2.3
Hair/balding pattern: Pattern 4	1.8	4.2	6.3	2.5	-1.0	-2.3
Medication: Ventolin 100micrograms inhaler	1.8	2.4	3.7	-1.9	1.8	0.6
Age at first live birth	1.8	3.1	5.4	2.3	-1.9	-0.6
BMI	1.7	10.1	16.9	-4.1	0.6	3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.6	-1.9	0.2	1.8
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	5.1	-0.7	-2.2	0.6
Serious illness, injury or assault to yourself	1.7	2.1	2.9	1.7	-1.5	-1.0
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	15.1	-0.1	-1.3	3.9
Depression (self-reported)	1.7	2.1	3.5	-1.9	-1.5	-0.6
Smoking status: Previous	1.7	2.5	3.5	-1.0	1.9	1.7
Back pain experienced in last month	1.7	2.5	4.3	-1.3	1.2	2.1
Mineral and other dietary supplements	1.7	2.2	6.6	-0.4	-2.6	0.0
Alzheimer’s Disease (in mother)	1.6	1.8	4.5	-0.8	2.1	-0.6
Triglycerides	1.6	2.6	6.1	-1.3	2.5	0.2
Forced vital capacity (FVC)	1.6	6.3	17.3	-0.5	-1.1	4.2
Qualifications: None of the above	1.6	3.4	4.2	2.0	-1.4	-2.1
Alcohol intake versus 10 years previously	1.6	2.4	4.9	-1.5	2.2	-0.1
Medication: Lansoprazole	1.6	1.8	2.7	-1.1	1.6	1.3
Exposure to tobacco smoke at home	1.6	1.7	4.0	-0.8	2.0	0.7
Medication: Paracetamol	1.6	2.7	4.2	2.0	-0.2	-2.1
Mother’s age at death	1.6	2.0	3.3	-0.6	1.8	1.6
Supplements: Calcium	1.6	1.7	5.0	0.0	2.2	0.4
Taking other prescription medications	1.5	2.3	5.7	-2.4	0.1	1.1
Body mass index (BMI)	1.5	6.2	11.6	-3.4	0.4	2.6
Birth weight	1.5	3.3	7.4	-1.4	0.7	2.7
Qualifications: nursing, teaching	1.5	2.3	6.6	-0.5	-2.6	0.4
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.5	-0.6	1.2	1.9
Hip circumference	1.4	6.1	8.6	-1.4	-2.7	2.9
Glaucoma (self-reported)	1.4	1.6	3.9	-2.0	-0.9	0.4
Exposure to tobacco smoke outside home	1.4	1.9	5.0	-0.5	2.2	0.6
Migraine (self-reported)	1.4	1.7	2.7	1.0	-1.1	-1.7
Age at last live birth	1.4	2.0	2.7	1.6	-1.6	-0.9
Type 2 Diabetes (T2D) (2018)	1.3	2.4	4.4	-1.2	1.2	2.1
Diabetes (mother)	1.3	1.6	2.4	0.6	1.6	1.5
Number of incorrect matches in round	1.3	2.1	5.8	2.4	0.2	-0.7
Alcohol usually taken with meals	1.3	2.1	3.3	1.8	-1.7	0.3
Standing height	1.3	12.8	27.6	2.9	-5.3	1.5
Qualifications: College or University degree	1.3	4.0	5.8	-2.4	0.7	2.4
Neck or shoulder pain in last month	1.3	1.9	3.6	1.3	0.7	1.9
Medication: Seretide 50 evohaler	1.3	1.4	2.9	-1.2	-0.1	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.7	-0.9	1.9	0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.0	-0.6	-2.0	-0.2
Ever had bowel cancer screening	1.3	1.5	2.3	-1.5	1.3	0.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.5	2.1	-0.0	0.0
Worry (Nagel 2018)	1.2	2.5	3.6	-1.9	1.7	0.9
Blood White Count	1.2	8.6	12.2	1.3	-3.5	-3.4
Smoking Status	1.2	2.8	4.6	-1.7	0.9	2.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	1.9	0.1	-1.4	1.4
Weight	1.2	5.9	10.3	-1.9	-1.9	3.2
Pulse rate	1.2	2.0	5.3	-0.8	2.3	-0.4
Arm fat mass (right)	1.2	5.1	7.8	-2.7	-0.7	2.8
Number of children fathered	1.2	1.4	4.1	-0.1	-2.0	0.2
Commuting to job workplace: Walk	1.2	1.3	2.3	1.5	0.6	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.8	-0.4	-1.1	1.7
Arm fat mass (left)	1.2	4.8	8.0	-2.5	-0.7	2.8
Average weekly beer plus cider intake	1.2	1.8	4.3	-0.9	2.1	-0.6
Irritability	1.2	2.1	4.6	-2.2	1.2	0.5
Unable to work because of sickness or disability	1.2	1.5	3.8	-0.5	-1.9	-0.7
LDL Cholesterol	1.1	1.7	3.8	-0.7	1.9	0.9
Primary Biliary Cirrhosis	1.1	1.5	2.5	1.0	-1.6	1.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	1.6	-1.0	-1.0	1.3
Supplements: Zinc	1.1	1.2	2.3	-0.2	1.2	1.5
Hair/balding pattern: Pattern 3	1.1	1.7	2.5	-1.5	1.6	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.6	-1.2	-1.0	1.3
Arm fat-free mass (right)	1.1	5.6	11.4	-0.9	-2.1	3.4
Pulse wave peak to peak time	1.1	1.3	2.4	1.5	-1.1	-0.4
Arm predicted mass (right)	1.1	5.6	10.9	-0.9	-2.2	3.3
Arm fat percentage (left)	1.1	4.3	8.0	-2.8	0.3	2.2
Medication: Blood pressure	1.1	2.0	4.5	1.1	-2.1	-0.5
Medication: Bendroflumethiazide	1.1	1.6	4.8	0.3	0.2	-2.2
Basal metabolic rate	1.1	6.3	13.5	-1.2	-2.0	3.7
Arm fat-free mass (left)	1.1	5.4	10.4	-0.7	-2.3	3.2
Number of operations (self-reported)	1.1	1.6	4.2	0.3	-2.1	0.6
Arm predicted mass (left)	1.1	5.7	11.5	-0.9	-2.2	3.4
Mean Putamen Volume	1.0	1.2	1.8	-1.3	-0.4	1.2
Leg fat-free mass (left)	1.0	5.4	12.5	-1.2	-1.5	3.5
Current tobacco smoking	1.0	1.6	2.2	-1.5	-0.9	1.3
Age when periods started (menarche)	1.0	2.4	4.2	0.2	2.0	-1.7
Leg predicted mass (left)	1.0	5.4	12.4	-1.3	-1.5	3.5
Waist circumference	1.0	3.5	7.3	-1.7	-0.5	2.7
Impedance of arm (right)	1.0	4.9	6.7	2.6	-1.2	-2.5
Arm fat percentage (right)	1.0	4.1	7.7	-2.8	0.3	2.1
Trunk fat-free mass	1.0	5.5	11.7	-0.9	-2.0	3.4
Trunk predicted mass	1.0	5.5	12.0	-0.8	-1.9	3.5
Gout (self-reported)	1.0	1.3	3.0	1.0	-1.7	-0.0
Health satisfaction	1.0	1.3	3.1	-0.9	-0.3	1.7
Leg fat mass (right)	1.0	4.0	4.3	-2.1	-2.0	1.9
Whole body fat-free mass	1.0	5.9	13.3	-1.0	-1.9	3.6
Leg fat-free mass (right)	1.0	5.1	12.5	-0.9	-1.4	3.5
Eye problems/disorders: Cataract	1.0	1.1	2.4	-0.9	0.3	1.6
Whole body water mass	1.0	6.0	14.0	-1.1	-1.7	3.7
Leg predicted mass (right)	1.0	5.3	13.2	-1.0	-1.3	3.6
Alcohol drinker status: Previous	1.0	1.2	3.0	0.6	1.7	-0.3
Leg fat mass (left)	1.0	4.0	4.1	-2.0	-2.0	1.9
Fasting Glucose	0.9	1.0	2.2	0.9	0.3	-1.5
Rheumatoid Arthritis	0.9	1.3	2.5	-1.0	-1.6	-0.5
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.8	0.1	1.2	1.3
Hand grip strength (left)	0.9	2.4	3.1	1.7	-1.8	-1.1
Vitamin and mineral supplements	0.9	1.2	3.1	-0.7	-1.8	-0.4
Severe depression (siblings)	0.9	1.1	2.1	-0.3	-1.0	-1.5
Sitting height	0.9	6.7	13.8	0.9	-3.7	2.4
Trunk fat mass	0.9	3.8	4.5	-1.6	-2.1	2.1
Had other major operations	0.9	1.1	2.1	0.6	-0.9	1.4
Time employed in main current job	0.9	1.0	1.9	-0.8	-1.4	0.7
Pulse wave Arterial Stiffness index	0.9	1.1	2.2	-1.5	0.9	0.5
Impedance of arm (left)	0.9	4.1	6.2	2.5	-1.3	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.6	-0.1	1.6	0.8
Medication: Blood pressure	0.9	1.7	3.7	1.0	0.4	-1.9
Medication: Gliclazide	0.9	1.0	2.5	-0.2	-1.6	0.6
Medication: Atorvastatin	0.9	1.1	2.4	0.7	-1.5	-0.8
Schizophrenia vs Biploar Disorder	0.8	1.1	1.7	-0.7	-0.9	-1.3
Prostate Cancer	0.8	1.2	1.7	1.2	-1.3	-0.4
Systolic blood pressure, automated reading	0.8	2.3	5.7	0.2	-1.1	-2.4
Qualifications: CSEs or equivalent	0.8	1.0	2.9	0.0	-1.7	-0.2
High blood pressure (siblings)	0.8	1.1	3.4	-0.2	0.0	1.8
Leg fat percentage (right)	0.8	2.8	3.6	-1.9	-1.8	1.2
Whole body fat mass	0.8	3.3	4.4	-1.6	-1.7	2.1
Leg pain on walking	0.8	1.0	2.6	-0.6	0.2	1.6
Mood swings	0.8	1.5	3.5	-1.9	0.7	0.7
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	-1.0	-0.1	1.4
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.0	0.4	1.7	-0.3
High cholesterol (Self-reported)	0.8	1.5	3.2	-1.1	1.8	0.5
Commuting to job workplace: Cycle	0.8	1.0	1.9	1.0	0.2	1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.3	0.8	1.5	0.1
Crohns Disease (2012)	0.7	1.1	2.0	1.4	-1.1	-0.4
Height	0.7	13.4	32.6	2.2	-5.7	1.6
Chronotype (morning person)	0.7	1.6	2.3	1.5	-0.7	1.5
Tanning	0.7	8.2	10.2	2.9	-3.2	-2.4
Diabetes (father)	0.7	0.8	1.9	1.4	-0.2	-0.7
Trunk fat percentage	0.7	2.7	2.9	-1.7	-1.7	1.5
Multivitamins +/- minerals	0.7	0.9	2.2	1.5	0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.1	0.4	-1.4	0.6
Allergy	0.7	1.6	2.8	1.4	0.2	-1.7
Illnesses of siblings	0.7	1.0	2.7	0.4	-0.2	-1.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.0	0.1	-1.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.3	0.0	-1.5	1.1
Body fat percentage	0.7	2.6	3.9	-2.0	-1.2	1.6
Number of full brothers	0.7	0.9	1.9	-0.9	-0.0	1.4
Comparative height size at age 10	0.7	4.0	10.1	1.2	-3.2	0.7
Knee pain experienced in last month	0.7	1.1	1.6	-0.5	1.2	1.3
Illnesses of siblings: Diabetes	0.7	0.8	1.6	-0.0	1.0	1.3
Medication for cholesterol	0.7	1.0	3.1	-0.1	1.8	-0.1
Smoking status: Current	0.7	1.1	1.3	-1.1	-0.8	1.1
Leg fat percentage (left)	0.7	2.6	3.5	-1.6	-1.9	1.2
Sensitivity / hurt feelings	0.6	1.0	1.6	-1.3	0.9	0.7
Hand grip strength (right)	0.6	1.7	3.6	0.3	-1.9	-1.1
Relative age voice broke	0.6	0.9	2.1	0.4	0.5	-1.5
Nervous feelings	0.6	1.1	1.1	-1.1	1.1	1.0
Father’s age at death	0.6	0.8	1.5	0.7	0.7	1.2
Illnesses of mother	0.6	0.7	1.0	-0.7	-1.0	0.7
Medication for pain relief, constipation, heartburn	0.6	1.0	2.8	-1.7	-0.1	0.4
Medication: Omeprazole	0.6	0.7	1.7	1.3	0.6	0.3
Had major operations	0.6	0.7	1.8	1.4	-0.5	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-1.1	0.2	0.9
Crohns Disease (2017)	0.5	1.2	1.4	0.9	-1.1	1.2
Hypothyroidism (self reported)	0.5	1.1	2.8	-1.7	0.4	0.5
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.1	-1.2	-0.2
Pack years adult smoking proportion	0.5	0.7	1.5	-1.2	-0.8	0.1
Medication: Levothyroxine sodium	0.5	0.9	2.5	-1.6	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.6	-1.3	-0.1
Number of live births	0.5	0.8	1.1	-0.7	0.8	-1.0
Noisy workplace	0.5	0.6	1.7	0.4	-0.3	1.3
Breastfed as a baby	0.5	0.6	0.9	-0.5	0.9	0.9
Loud music exposure frequency	0.5	0.5	0.9	-0.7	-0.4	1.0
Comparative body size at age 10	0.5	1.5	2.7	-1.6	-0.3	1.3
Medication: Allopurinol	0.5	0.7	1.1	1.1	-0.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	0.7	1.1	-0.4
Alcohol intake frequency.	0.5	1.1	2.5	-0.2	1.6	-0.9
Illnesses of father: Heart disease	0.5	0.7	1.9	-0.4	1.4	-0.0
Illnesses of father: None of the above (group 1)	0.5	0.7	1.2	1.1	-0.9	0.1
Risk taking	0.5	0.7	1.1	-1.0	-0.3	1.1
Fractured/broken bones in last 5 years	0.5	0.7	1.0	1.0	0.9	0.5
Age started oral contraceptive pill	0.5	0.6	0.7	0.6	-0.8	0.8
Major Depression (MDD)	0.4	0.5	0.8	-0.9	-0.4	0.7
HDL Cholesterol	0.4	0.7	2.1	-1.4	0.0	0.1
Lung FEV1/FVC ratio	0.4	1.9	5.2	0.3	-0.6	2.3
Medication: Co-codamol	0.4	0.5	1.1	-1.1	0.3	0.6
Stomach or abdominal pain in last month	0.4	0.5	1.6	0.2	-0.0	-1.3
High blood pressure (mother)	0.4	0.5	1.3	0.2	-1.1	-0.5
Mouth/teeth dental problems	0.4	0.7	1.6	0.1	-0.6	1.3
Heart attack	0.4	0.6	0.8	-0.9	0.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.2	-0.3	0.5	1.5
Peak expiratory flow (PEF)	0.4	0.9	2.3	1.5	-0.7	0.1
Pulse wave reflection index	0.4	0.5	1.2	-0.1	-0.4	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-1.3	-0.5	0.6
Overall health rating	0.4	0.8	2.2	-1.5	0.3	0.1
Supplements: Vitamin C	0.4	0.5	0.9	0.5	1.0	0.5
Osteoporosis (self-reported)	0.4	0.5	0.9	-0.6	0.6	1.0
Medication: Aspirin	0.4	0.6	1.1	1.1	0.3	-0.8
Number of self-reported non-cancer illnesses	0.4	0.6	1.8	-1.3	-0.0	0.3
Diastolic blood pressure, automated reading	0.4	1.3	3.8	-0.5	-2.0	0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	0.8	-0.8	-0.4
Alzheimer’s Disease (in father)	0.3	0.4	0.6	0.8	0.7	0.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.0	0.8	-0.9	1.0
Breast Cancer	0.3	0.6	1.1	-1.0	0.5	0.8
Ovarian Cancer	0.3	0.3	1.0	-0.1	-1.0	0.2
Age at First Birth	0.3	0.4	0.9	-0.3	0.3	-1.0
Heel T-Score	0.3	2.6	3.9	0.8	-2.0	-1.8
Waist Hip Ratio (WHR)	0.3	1.3	2.9	1.0	1.7	-0.4
Relative age of first facial hair	0.3	0.6	1.0	-0.8	0.3	1.0
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	-0.2	-1.0	0.0
Medication: Metformin	0.3	0.4	0.8	-0.7	-0.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	-0.5	-1.2	-0.6
Diabetes (self-reported)	0.3	0.4	1.1	-0.2	0.5	1.0
Medication: Ramipril	0.3	0.4	0.7	0.6	0.1	-0.8
Prospective memory result	0.3	0.3	0.5	0.7	-0.2	0.6
Birth weight of first child	0.3	0.5	1.3	1.1	0.4	0.1
Blood clot in the leg (DVT)	0.3	0.3	0.5	0.7	-0.7	-0.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	-0.6	0.7	-0.1
Medication: Ibuprofen	0.3	0.3	0.8	0.9	0.1	-0.4
Medication: Aspirin	0.3	0.4	0.9	1.0	-0.0	-0.5
Hypertension (Self-reported)	0.3	0.8	2.0	0.3	-1.4	-0.7
Average weekly red wine intake	0.3	0.4	0.7	-0.9	0.1	0.7
Diabetes diagnosed by doctor	0.3	0.4	1.1	-0.2	0.4	1.0
Breast cancer (self-reported)	0.3	0.3	0.7	0.9	-0.4	-0.1
Osteoarthritis (self-reported)	0.3	0.4	0.9	-0.4	0.1	1.0
Hearing aid user	0.3	0.4	0.7	-0.3	-0.5	-0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.5	-0.8	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.9	0.2	-0.7
Pack years of smoking	0.3	0.4	0.8	-0.6	-0.9	-0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.1	-0.3	0.7
Lupus	0.2	0.3	0.8	-0.9	0.2	0.4
Ulcerative Colitis	0.2	0.3	0.7	0.8	-0.6	-0.0
Blood Eosinophil Count	0.2	1.4	4.3	-2.1	-0.0	0.0
Blood Platelet Count	0.2	1.8	2.2	1.1	1.5	-1.5
Allergy or Eczema	0.2	0.6	1.2	-0.7	-0.5	1.1
Number of treatments/medications taken	0.2	0.4	0.8	-0.9	0.1	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.7	-0.0	-0.8	0.3
Angina	0.2	0.2	0.7	-0.8	0.1	0.1
Maternal smoking around birth	0.2	0.3	0.3	-0.6	-0.5	-0.6
High blood pressure	0.2	0.5	1.4	-0.2	-1.2	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.8	-0.3	0.3
Angina (self-reported)	0.2	0.2	0.6	-0.8	0.2	0.2
Pulse rate, automated reading	0.2	0.5	0.9	0.4	0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.5	-0.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.6	-0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.8	-0.4	0.0
Medication: Lisinopril	0.2	0.3	0.4	0.6	0.6	0.4
Myopia	0.2	0.3	0.5	-0.7	0.6	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.7	0.4	1.3	0.2
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.5	-0.6	0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.3	-0.5	-0.1
HbA1C	0.1	0.1	0.2	-0.5	-0.2	0.2
Blood Red Count	0.1	1.4	3.8	0.2	-0.7	-2.0
Hair Pigment	0.1	1.6	2.0	-1.0	1.4	-1.4
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	-0.0	0.3
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	-0.2	0.0	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.0	-0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.0	-0.4	-0.7
Pain all over the body in last month	0.1	0.1	0.1	-0.3	0.2	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.5	0.1	0.6
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.2	-0.2	-0.5
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.3	-0.5	0.4
Cholesterol lowering medication	0.1	0.1	0.3	-0.6	-0.2	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.0	0.6	-0.3
Cardiovascular Disease	0.0	0.2	0.3	-0.4	-0.1	0.6
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	-0.2	-0.1	-0.3
Had menopause	0.0	0.1	0.1	-0.3	-0.2	0.0
Suffer from ‘nerves’	0.0	0.1	0.1	-0.4	0.1	-0.2
Pain experienced in last month	0.0	0.0	0.1	-0.2	-0.1	-0.1

Hub : Genes

APBB3

Models

Trait associations