[Hub]/) : Traits : Lung FVC : ← →

chr5:129,797,129-133,140,038

Best TWAS P=4.92e-21 · Best GWAS P=4.16e-17 conditioned to 0.302

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RAPGEF6	0.16	0.09	enet	25	0.11	4.4e-13	5.7	6.5	7.0e-11	-0.44	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	-8.4	6.7	1.5e-11	-0.87	0.01	0.98	FALSE
3	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	-8.0	-8.0	1.7e-15	0.90	0.10	0.90	FALSE
4	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	-8.0	-7.7	1.3e-14	0.92	0.09	0.82	FALSE
5	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	-7.8	-7.8	4.8e-15	0.92	0.15	0.85	FALSE
6	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	4.4	7.4	1.9e-13	-0.49	0.50	0.14	FALSE
7	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	-8.4	8.0	1.3e-15	-0.92	0.00	1.00	FALSE
8	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	-7.9	-6.8	1.5e-11	0.90	0.14	0.86	FALSE
9	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	4.5	-6.5	1.1e-10	0.85	0.13	0.76	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	SLC22A5	0.15	0.00	enet	24	0.05	1.4e-02	4.6	-5.3	1.5e-07	0.47	0.11	0.11	FALSE
11	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	-7.7	8.2	1.8e-16	-0.74	0.04	0.94	FALSE
12	GTEx	Breast Mammary Tissue (Female)	SLC22A5	0.04	-0.01	lasso	3	0.01	1.3e-01	4.4	5.8	7.1e-09	-0.54	0.04	0.26	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	-7.7	7.9	3.6e-15	-0.85	0.02	0.96	FALSE
14	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	5.6	6.7	1.9e-11	-0.91	0.05	0.95	FALSE
15	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	-7.7	6.7	2.0e-11	-0.86	0.02	0.96	FALSE
16	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	4.9	-5.3	1.5e-07	0.79	0.92	0.04	FALSE
17	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	-8.0	-6.6	3.1e-11	0.87	0.03	0.97	FALSE
18	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	-7.7	8.2	1.7e-16	-0.94	0.04	0.96	FALSE
19	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	-8.0	-7.5	6.0e-14	0.89	0.02	0.98	FALSE
20	GTEx	Esophagus Muscularis	FNIP1	0.06	0.00	enet	14	0.01	4.9e-02	6.2	-5.4	8.5e-08	0.29	0.26	0.03	FALSE
21	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	5.0	-6.2	7.0e-10	0.81	0.46	0.54	FALSE
22	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	-7.7	8.2	2.0e-16	-0.96	0.01	0.99	FALSE
23	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	5.0	-7.6	2.2e-14	0.80	0.29	0.71	FALSE
24	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	4.2	5.3	1.0e-07	-0.38	0.88	0.08	FALSE
25	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	-5.7	-7.7	1.1e-14	0.84	0.25	0.74	FALSE
26	GTEx	Pancreas	P4HA2	0.22	0.21	lasso	13	0.20	5.3e-09	7.4	-8.8	1.3e-18	0.54	0.72	0.26	FALSE
27	GTEx	Pancreas	P4HA2-AS1	0.16	0.16	lasso	5	0.16	3.2e-07	7.4	-8.3	1.6e-16	0.46	0.61	0.29	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	-7.7	7.4	1.7e-13	-0.89	0.03	0.95	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	4.9	6.6	4.6e-11	-0.69	0.14	0.14	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	5.1	6.6	5.6e-11	-0.90	0.04	0.96	FALSE
31	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	-8.0	7.3	2.1e-13	-0.94	0.01	0.99	FALSE
32	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	-8.4	7.9	3.7e-15	-0.99	0.00	1.00	FALSE
33	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	-7.7	-7.2	5.5e-13	0.97	0.03	0.92	FALSE
34	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	-8.0	-8.2	3.4e-16	0.94	0.01	0.99	FALSE
35	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	4.5	-5.4	6.7e-08	0.77	0.23	0.19	FALSE
36	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	-7.8	-7.7	1.8e-14	0.89	0.13	0.84	FALSE
37	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	-5.7	6.2	4.3e-10	-0.87	0.02	0.95	FALSE
38	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	4.2	7.4	2.0e-13	-0.75	0.03	0.97	FALSE
39	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	-7.8	-8.0	1.1e-15	0.86	0.10	0.87	FALSE
40	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	-7.7	7.7	1.0e-14	-0.99	0.08	0.92	FALSE
41	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	-8.4	5.3	1.2e-07	-0.86	0.01	0.99	FALSE
42	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	-7.9	-9.0	1.5e-19	0.81	0.13	0.87	FALSE
43	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	-5.7	5.8	6.5e-09	-0.77	0.83	0.11	FALSE
44	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	-7.7	7.7	1.0e-14	-0.99	0.01	0.99	FALSE
45	NTR	Blood	ACSL6	0.01	0.00	bslmm	399	0.00	2.8e-02	4.6	6.3	2.9e-10	-0.49	0.21	0.16	FALSE
46	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	3.5	5.5	3.3e-08	-0.43	0.21	0.23	FALSE
47	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	-4.3	6.8	1.1e-11	-0.70	0.03	0.96	FALSE
48	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	-7.1	6.7	1.6e-11	-0.55	0.33	0.55	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	AC034220.3	0.04	0.02	blup	415	0.04	1.3e-05	3.2	-5.2	1.9e-07	0.67	0.94	0.04	FALSE
50	YFS	Blood	HSPA4	0.17	0.02	blup	433	0.09	2.8e-27	-4.9	6.1	8.9e-10	-0.16	0.24	0.76	TRUE
51	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	5.0	5.6	2.7e-08	-0.81	1.00	0.00	FALSE
52	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	-7.7	7.8	5.7e-15	-0.97	0.12	0.88	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSPA4	0.03	0.02	blup	50	0.02	5.8e-05	-4.9	5.6	2.3e-08	-0.04	0.02	0.97	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	-7.9	-9.4	4.9e-21	0.78	0.01	0.99	TRUE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	-7.7	7.0	2.5e-12	-0.87	0.02	0.97	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZCCHC10	0.03	0.02	blup	30	0.02	1.3e-05	-4.9	5.4	7.4e-08	-0.03	0.07	0.91	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	5.6	5.4	5.8e-08	-0.84	0.03	0.91	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	5.0	5.5	4.6e-08	-0.84	0.10	0.90	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LEAP2	0.08	0.08	enet	4	0.09	3.7e-10	-5.6	-5.9	4.2e-09	-0.07	0.01	0.99	TRUE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A5	0.06	0.04	blup	93	0.04	8.9e-06	4.0	-5.6	2.6e-08	0.39	0.63	0.06	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SHROOM1	0.05	0.01	blup	38	0.02	2.5e-02	-3.5	-5.2	1.6e-07	0.09	0.01	0.67	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	3.4	-5.7	1.0e-08	0.48	0.14	0.09	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	2.7	5.2	1.8e-07	-0.82	0.03	0.97	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	P4HA2	0.04	0.01	blup	47	0.03	4.4e-04	7.5	-8.0	1.8e-15	0.47	0.04	0.29	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	5.0	5.9	4.8e-09	-0.84	0.05	0.95	FALSE
66	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RAPGEF6	0.13	0.07	blup	99	0.06	8.8e-03	5.6	-5.4	5.4e-08	0.38	0.04	0.57	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	-7.5	-6.6	5.0e-11	0.88	0.00	0.92	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	-7.9	-8.3	7.5e-17	0.89	0.01	0.99	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	5.6	5.6	2.3e-08	-0.80	0.02	0.68	FALSE