[Hub]/) : Traits : Lung FVC : ← →

chr6:154,487,421-156,330,580

Best TWAS P=2e-11 · Best GWAS P=5.17e-11 conditioned to 0.0375

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RP11-477D19.2	0.10	0.07	lasso	2	0.05	3.0e-05	6.4	6.4	1.2e-10	-0.79	0.02	0.98	FALSE
2	GTEx	Adrenal Gland	TFB1M	0.42	0.23	lasso	7	0.28	8.4e-11	6.5	5.9	2.8e-09	-0.64	0.03	0.97	FALSE
3	GTEx	Adrenal Gland	RP11-477D19.2	0.36	0.34	lasso	6	0.35	2.5e-13	6.1	6.6	4.7e-11	-0.76	0.03	0.97	FALSE
4	GTEx	Brain Cerebellar Hemisphere	RP11-477D19.2	0.56	0.48	lasso	7	0.50	8.6e-15	5.2	6.0	2.1e-09	-0.75	0.03	0.97	FALSE
5	GTEx	Brain Cerebellum	RP11-477D19.2	0.60	0.52	lasso	5	0.53	3.0e-18	6.4	6.4	1.2e-10	-0.79	0.02	0.98	FALSE
6	GTEx	Brain Hypothalamus	RP11-477D19.2	0.52	0.26	lasso	6	0.31	6.0e-08	6.2	6.5	1.1e-10	-0.78	0.03	0.96	FALSE
7	GTEx	Breast Mammary Tissue	RP11-477D19.2	0.19	0.15	lasso	7	0.12	1.3e-06	6.5	6.6	4.1e-11	-0.79	0.02	0.98	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	TFB1M	0.27	0.19	lasso	2	0.17	3.1e-06	-6.1	6.1	8.5e-10	-0.95	0.08	0.85	FALSE
9	GTEx	Cells Transformed fibroblasts	TFB1M	0.17	0.07	enet	21	0.10	6.3e-08	6.2	6.1	1.3e-09	-0.76	0.03	0.97	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-477D19.2	0.13	0.07	lasso	2	0.07	1.2e-05	6.5	6.6	5.2e-11	-0.80	0.02	0.98	FALSE
11	GTEx	Colon Transverse	TFB1M	0.21	0.11	enet	14	0.17	1.6e-08	6.5	5.8	8.9e-09	-0.72	0.03	0.97	FALSE
12	GTEx	Colon Transverse	RP11-477D19.2	0.21	0.24	lasso	11	0.21	2.3e-10	6.4	6.4	2.0e-10	-0.76	0.03	0.97	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	TFB1M	0.20	0.05	lasso	3	0.08	1.1e-03	6.3	6.2	7.1e-10	-0.63	0.03	0.83	FALSE
14	GTEx	Esophagus Mucosa	RP11-477D19.2	0.15	0.11	enet	10	0.09	6.9e-07	6.4	6.4	1.7e-10	-0.79	0.03	0.97	FALSE
15	GTEx	Heart Atrial Appendage	RP11-477D19.2	0.15	0.12	lasso	1	0.10	2.1e-05	6.5	6.5	1.0e-10	-0.68	0.02	0.95	FALSE
16	GTEx	Heart Left Ventricle	TFB1M	0.27	0.22	lasso	10	0.23	1.4e-12	3.8	5.5	4.2e-08	-0.62	0.28	0.72	FALSE
17	GTEx	Heart Left Ventricle	RP11-477D19.2	0.19	0.13	lasso	2	0.12	1.0e-06	5.2	5.3	1.4e-07	-0.68	0.04	0.96	FALSE
18	GTEx	Nerve Tibial	RP11-477D19.2	0.28	0.17	lasso	6	0.16	1.2e-11	6.4	6.1	8.7e-10	-0.76	0.02	0.98	FALSE
19	GTEx	Pituitary	RP11-477D19.2	0.45	0.29	lasso	8	0.20	8.4e-06	6.4	6.4	1.2e-10	-0.79	0.02	0.98	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	RP11-477D19.2	0.24	0.21	enet	21	0.19	7.1e-11	6.3	6.4	1.8e-10	-0.69	0.03	0.97	FALSE
21	GTEx	Skin Sun Exposed Lower leg	RP11-477D19.2	0.23	0.25	lasso	4	0.25	1.2e-20	6.1	6.6	5.3e-11	-0.78	0.03	0.97	FALSE
22	GTEx	Stomach	TFB1M	0.19	0.09	enet	14	0.09	2.8e-05	5.5	5.2	2.1e-07	-0.55	0.11	0.87	FALSE
23	GTEx	Stomach	RP11-477D19.2	0.21	0.17	lasso	5	0.16	7.2e-08	6.5	6.7	2.0e-11	-0.79	0.03	0.97	TRUE
24	GTEx	Testis	RP11-477D19.2	0.23	0.08	enet	17	0.13	2.5e-06	-6.6	6.0	1.6e-09	-0.84	0.02	0.98	FALSE
25	GTEx	Thyroid	TFB1M	0.24	0.09	lasso	6	0.09	2.7e-07	6.5	6.2	5.6e-10	-0.75	0.02	0.98	FALSE
26	GTEx	Thyroid	RP11-477D19.2	0.29	0.28	lasso	7	0.27	1.1e-20	6.1	6.5	8.4e-11	-0.77	0.04	0.96	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	TIAM2	0.08	0.02	blup	635	0.02	7.6e-04	-3.9	6.4	1.7e-10	-0.71	0.03	0.96	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	RP11-477D19.2	0.26	0.35	lasso	6	0.37	4.7e-50	6.4	6.5	7.8e-11	-0.77	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLDN20	0.02	0.00	blup	79	0.01	8.0e-03	-3.7	-5.5	4.5e-08	0.69	0.03	0.31	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TFB1M	0.16	0.17	lasso	6	0.19	1.3e-20	3.8	5.4	5.4e-08	-0.67	0.52	0.48	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TIAM2	0.05	0.01	blup	265	0.01	7.3e-03	6.2	5.2	1.9e-07	-0.67	0.03	0.62	FALSE
32	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TFB1M	0.06	0.07	lasso	3	0.06	5.8e-04	5.5	6.1	8.2e-10	-0.69	0.04	0.90	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	TFB1M	0.18	0.19	lasso	9	0.19	1.9e-21	5.5	5.1	3.0e-07	-0.59	0.70	0.30	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TFB1M	0.15	0.11	blup	94	0.08	3.2e-04	6.3	6.2	4.9e-10	-0.72	0.03	0.94	FALSE
35	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TFB1M	0.11	0.00	blup	93	0.06	1.1e-02	4.1	5.9	4.0e-09	-0.80	0.02	0.57	FALSE