Hub : Genes

TIAM2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Thyroid 0.1570 0.0550 0.00320 0.002 NA 0.032 NA 0.024 2.3e-01 NA 1.5e-03 NA 6.0e-03
2 GTEx Whole Blood 0.1350 0.0450 0.00170 0.053 NA 0.039 NA 0.032 1.2e-05 NA 1.4e-04 NA 6.2e-04
3 NTR Blood 0.2450 0.0305 0.00000 0.089 0.121 0.128 0.028 0.129 3.5e-27 5.5e-37 3.1e-39 1.9e-09 2.1e-39
4 ROSMAP Brain Pre-frontal Cortex 0.0769 0.0243 0.00011 0.016 0.021 0.020 0.020 0.020 3.6e-03 7.6e-04 1.1e-03 1.2e-03 1.2e-03
5 YFS Blood 0.6148 0.0244 0.00000 0.335 0.540 0.570 0.546 0.566 6.5e-114 2.9e-215 9.4e-234 1.5e-218 6.7e-231
6 TCGA Breast Invasive Carcinoma 0.0378 0.0144 0.00270 0.016 0.008 0.005 NA 0.010 2.6e-04 6.1e-03 2.5e-02 NA 2.7e-03
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0470 0.0219 0.00900 0.006 0.015 0.005 NA 0.006 5.9e-02 7.3e-03 7.5e-02 NA 6.1e-02
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.1320 0.0470 0.00034 0.076 0.069 0.026 NA 0.055 3.7e-05 8.5e-05 1.2e-02 NA 4.2e-04
9 TCGA Pheochromocytoma and Paraganglioma 0.1300 0.0580 0.00880 0.012 0.025 0.004 NA 0.024 1.0e-01 3.4e-02 2.1e-01 NA 3.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 1.1 1.7 5.7 -0.7 0.5 0.9 1.2 -0.1 -1.4 0.5 2.4 2.1
Bipolar Disorder or Schizophrenia 0.9 2.2 7.1 0.6 0.6 0.5 1.1 -0.3 -1.8 1.4 2.2 2.7
Depressed Affect (Nagel 2018) 0.5 1.1 5.6 1.1 -0.5 0.1 2.4 -0.0 0.5 1.0 -0.5 1.2
Depression (Nagel 2018) 0.9 1.4 8.4 0.7 -0.2 0.2 2.9 -0.1 -0.2 1.6 -0.2 1.0
Intelligence (Savage-Jansen 2018) 1.7 5.3 14.2 0.3 -1.8 -1.6 -1.5 -1.5 -2.6 -3.8 -3.0 -2.7
Neuroticism (Nagel 2018) 0.3 0.8 1.6 0.4 -0.4 -1.3 1.2 -0.8 0.7 -0.9 -1.3 0.0
Schizophrenia (2018) 0.5 1.0 3.0 1.4 0.2 -0.2 0.3 -0.3 -1.1 1.4 0.9 1.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 0.1 -0.5 -0.7 -0.4 -0.9 0.5 0.1 -0.8 0.6
Worry (Nagel 2018) 0.8 1.8 8.0 0.3 -0.2 -2.8 0.0 -1.9 0.3 -1.9 -0.5 -0.7
Alzheimer’s Disease (in mother) 0.9 1.0 5.0 0.1 2.2 -0.6 -1.6 0.3 1.0 0.0 -0.7 -0.0
Alzheimer’s Disease (in father) 0.9 1.0 3.2 -0.1 -1.8 -0.4 -1.5 -0.2 0.7 -1.1 -1.2 0.0
Alzheimer’s Disease (including proxy) 0.5 0.7 3.3 -0.9 0.7 -0.4 -1.8 -0.1 0.8 0.6 -0.1 0.7
Crohns Disease (2017) 0.3 0.8 4.1 -0.2 -2.0 0.1 0.2 -0.7 0.4 1.0 -0.3 1.0
Irritable Bowel Disease (IBD) 0.2 0.5 1.2 -0.0 -0.8 1.0 -1.1 0.4 -0.7 -0.4 -0.9 -0.5
Ulcerative Colitis (UC) 0.9 1.8 4.0 -0.3 0.3 1.3 -1.9 1.1 -0.9 -1.5 -1.5 -2.0
Major Depression (MDD) 0.7 0.9 2.8 0.6 -0.9 0.7 1.7 0.1 0.1 1.4 0.5 1.0
Reaction Time 0.7 1.3 3.5 0.4 -0.9 -0.9 1.9 -1.1 1.1 1.2 -0.4 1.7
Verbal and Numeric Reasoning (VNR) 2.0 4.9 12.6 -0.9 -1.8 -1.0 -1.6 -1.4 -2.4 -3.6 -2.9 -2.8
Breast Cancer 0.5 1.2 3.6 -0.6 1.6 0.7 0.8 0.5 0.2 0.5 1.6 1.9
Ovarian Cancer 0.6 0.7 2.0 -1.4 -0.9 0.1 -1.1 0.7 0.7 -1.0 0.7 -0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 2.1 -0.5 1.5 0.5 -1.0 0.4 0.7 0.1 0.0 -0.3
Bipolar Disorder (2011) 0.5 0.4 3.0 -0.8 0.1 0.3 0.1 0.4 0.0 0.0 1.7 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 4.0 -0.2 0.5 0.8 0.4 0.8 -2.0 -0.3 0.5 0.3
Coronary Artery Disease (CAD) 1.9 2.3 6.4 -0.7 -2.0 -0.2 2.5 -1.0 -1.8 2.2 0.7 0.5
Crohns Disease (2012) 0.5 0.9 1.8 -0.7 -1.2 -0.1 1.1 -0.9 -0.3 1.0 1.0 1.4
Mean Putamen Volume 0.5 0.6 1.6 -0.5 -0.6 -0.5 0.7 -0.7 -0.8 1.1 -0.4 1.3
Fasting Glucose 0.5 0.6 1.8 -1.1 0.4 -0.8 -0.2 -0.9 -0.6 -1.3 -0.2 -0.1
HbA1C 0.6 0.6 2.2 -0.3 -1.2 -1.0 0.3 -0.5 -0.4 1.5 0.4 -0.4
HDL Cholesterol 0.4 0.6 2.0 0.8 -0.0 0.6 -0.2 1.1 1.4 1.0 0.6 0.3
LDL Cholesterol 0.7 1.1 3.5 -0.9 1.0 -0.8 1.0 -0.7 0.0 0.5 1.9 1.3
Lupus 0.3 0.4 2.0 -1.4 0.9 -0.2 -0.6 -0.0 -0.7 -0.2 -0.3 -0.4
Neuroticism (2016) 0.2 0.2 0.5 0.5 0.4 -0.3 0.7 -0.4 -0.4 0.6 0.0 0.7
Primary Biliary Cirrhosis 0.8 1.1 3.6 0.3 0.1 1.2 -0.4 0.9 -1.2 -1.5 -0.3 -1.9
Rheumatoid Arthritis 0.5 0.7 4.2 0.3 2.0 -0.0 -0.1 0.4 -1.0 -0.3 -0.3 0.6
Schizophrenia (2014) 0.6 1.3 3.8 1.2 1.1 -0.1 0.2 -0.4 -0.7 1.1 1.9 1.9
Triglycerides 0.1 0.1 0.4 -0.5 0.6 -0.1 0.1 -0.2 0.7 -0.3 -0.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.0 1.1 0.6 0.1 -1.4 0.5 -0.3 -1.1 -0.9 -0.3
Ulcerative Colitis 0.8 1.2 3.3 -0.7 -0.2 1.2 -1.0 0.8 -1.8 -0.9 -0.3 -1.8
Blood Eosinophil Count 0.2 1.2 7.8 -1.2 1.0 -0.1 0.0 0.3 -0.6 -2.8 -0.3 -0.5
Blood Platelet Count 0.2 2.0 5.2 -0.9 1.9 0.8 2.1 1.0 -0.4 2.3 1.3 0.9
Blood Red Count 0.1 1.1 2.9 -1.1 0.1 1.6 1.2 1.2 -1.7 0.7 0.2 0.4
Blood White Count 0.3 2.4 7.5 -1.1 1.5 1.6 1.5 1.4 1.1 0.2 2.7 1.7
Heel T-Score 0.7 5.2 31.4 0.5 -0.6 0.1 2.8 -0.1 -5.6 -0.7 1.9 -1.8
BMI 0.7 4.0 9.6 -2.5 -1.1 2.1 3.1 1.7 -0.4 2.2 2.0 1.6
Height 1.3 25.9 72.6 2.2 0.0 -3.0 -4.6 -0.2 1.2 -8.5 -8.0 -7.7
Waist Hip Ratio (WHR) 0.1 0.6 1.9 0.2 -0.9 0.5 0.9 0.2 0.8 -0.6 0.6 1.4
Systolic Blood Pressure 1.1 5.4 15.1 1.3 0.1 0.6 -3.9 1.4 2.7 -2.1 -2.9 -3.1
Smoking Status 0.4 1.0 3.6 0.2 0.7 0.1 1.9 0.3 -0.6 0.3 1.6 1.3
Allergy or Eczema 0.3 0.7 2.2 -1.1 -0.3 -1.5 0.0 -1.4 -0.1 0.8 0.6 0.6
Cardiovascular Disease 0.2 0.6 1.7 0.2 0.7 0.8 -1.2 1.3 0.8 -0.3 -0.5 -0.0
Hypothyroidism (self reported) 0.9 2.2 6.7 0.9 1.7 1.2 0.6 1.4 -1.8 0.2 2.6 1.4
Respiratory disease 0.4 0.8 1.9 -0.0 0.9 -1.4 1.0 -1.2 -0.6 0.6 -0.5 1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.4 -0.7 -1.2 0.9 0.2 0.9 0.2 0.3 0.5 0.1
Lung FEV1/FVC ratio 0.4 1.9 5.2 0.8 -2.3 1.1 1.4 -0.4 -0.0 2.0 0.9 1.8
Lung FVC 2.4 12.1 40.8 0.6 -1.7 1.6 6.4 -1.1 0.2 5.2 3.3 4.8
Neuroticism 0.4 1.0 2.5 0.7 0.5 -1.6 0.8 -0.3 1.1 -1.1 -1.4 -0.8
Chronotype (morning person) 0.2 0.5 2.9 0.0 -0.1 0.3 -0.2 0.6 -1.7 -0.3 1.0 -0.5
Hair Pigment 0.0 1.1 2.9 -0.4 -1.1 -0.7 0.3 -0.3 0.6 1.4 -1.6 -1.7
Tanning 0.1 0.8 4.2 0.6 0.5 -0.8 -0.7 -0.7 2.0 -0.6 -0.1 0.2
Hand grip strength (left) 1.5 3.9 15.3 -0.7 -1.6 -1.0 -0.4 -0.7 0.3 -3.9 -2.7 -2.7
Number of treatments/medications taken 0.7 1.2 6.2 0.9 1.3 -0.5 -0.8 0.5 2.5 -0.2 -0.8 0.4
Average weekly spirits intake 0.8 0.9 2.4 -1.2 -0.5 -0.7 1.5 -1.2 -0.5 1.3 0.6 0.6
Sensitivity / hurt feelings 1.1 1.8 5.4 -0.0 2.3 1.4 -0.3 2.0 2.0 -0.7 0.5 0.1
Frequency of depressed mood in last 2 weeks 1.3 1.8 9.8 0.6 -0.2 -0.9 3.1 -0.7 -0.7 1.2 0.1 1.7
Hearing difficulty/problems: Yes 1.8 2.8 5.8 -0.2 -2.4 -0.7 1.9 -1.4 -1.2 2.4 1.4 2.0
Relative age of first facial hair 1.0 2.1 4.7 0.0 -0.2 -1.2 2.2 -1.7 -2.0 1.5 0.3 1.8
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.5 -0.6 1.1 1.1 1.1 1.0 0.6 0.1 1.6 0.6
Ever used hormone-replacement therapy (HRT) 0.4 0.6 2.0 -0.6 1.4 -0.5 0.7 -0.6 -0.3 -1.0 0.6 0.3
Ever had hysterectomy (womb removed) 0.5 0.5 1.6 -1.3 -0.4 -0.2 0.6 -0.3 0.7 -0.8 -1.1 -0.1
Systolic blood pressure, automated reading 1.9 5.6 15.7 -0.9 -0.3 -0.2 -3.9 0.7 1.5 -2.7 -2.9 -4.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.8 0.8 -1.1 -0.2 1.3 -0.0 -0.8 0.4 -0.3 0.3
Angina 1.0 1.3 4.2 0.6 -1.0 -0.3 0.6 -0.3 1.9 1.4 0.4 2.1
Medication for hormone replacement therapy 0.4 0.5 2.3 0.1 1.5 -0.2 0.5 0.4 -0.9 -0.7 0.1 0.1
Vitamin and mineral supplements 0.4 0.6 1.9 -1.2 -0.6 0.0 1.4 0.3 -0.5 0.8 -0.2 -0.9
Supplements: Zinc 0.3 0.4 0.8 -0.4 0.7 -0.9 -0.9 -0.2 0.9 -0.6 0.1 0.1
Medication: Co-codamol 0.6 0.6 2.1 0.4 -0.9 -0.9 0.8 -0.6 0.8 0.2 -0.3 1.4
Medication: Metformin 0.3 0.4 1.6 -0.3 -0.1 0.2 0.0 -0.0 1.3 0.9 0.9 0.5
Diabetes (father) 0.8 1.0 5.0 0.2 0.2 0.4 -2.2 1.3 -0.2 -0.8 -1.1 -0.7
Diabetes (mother) 0.9 1.2 2.9 0.7 1.2 1.1 -0.7 1.7 -1.4 -1.0 0.9 0.6
Severe depression (siblings) 1.7 1.9 4.9 0.5 -2.2 1.8 1.1 0.1 -1.0 1.5 0.7 1.7
Pack years adult smoking proportion 0.6 0.9 4.7 -0.8 0.7 -0.2 2.2 0.2 0.1 -0.1 1.3 0.8
Impedance of leg (right) 0.7 3.2 10.8 3.3 0.6 -0.7 1.5 -1.4 1.6 2.0 0.0 2.4
Leg fat-free mass (left) 0.6 3.1 6.8 -2.1 -1.4 1.2 -0.7 1.8 -0.9 -2.6 -1.5 -2.5
Trunk fat percentage 0.2 0.8 2.3 -0.5 -0.5 0.7 1.5 1.0 0.3 0.7 1.3 0.8
Hand grip strength (right) 0.9 2.3 7.9 -0.4 -0.1 0.7 -0.9 1.0 -1.2 -2.8 -1.6 -2.6
Townsend deprivation index at recruitment 0.2 0.3 1.1 -0.5 0.3 -1.1 0.5 -0.6 -0.6 0.1 0.1 -0.3
Current tobacco smoking 0.3 0.5 2.4 -0.3 0.8 -0.2 1.6 0.2 0.3 -0.7 0.8 0.7
Average weekly fortified wine intake 1.1 1.3 4.2 1.3 -2.1 -1.2 0.2 -1.1 -0.5 -0.2 -1.1 1.3
Maternal smoking around birth 0.6 0.8 1.9 -0.8 0.3 1.3 0.4 1.0 1.4 1.0 0.9 0.3
Fed-up feelings 1.0 1.9 9.7 0.2 -0.2 0.4 3.1 0.6 0.4 1.4 0.6 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 3.4 0.3 -0.0 -0.3 1.9 0.3 -0.6 0.9 -0.1 0.4
Relative age voice broke 1.1 1.7 6.1 -0.2 -1.0 -0.2 1.6 -0.6 -1.3 2.5 0.9 1.6
Taking other prescription medications 0.5 0.7 1.4 0.2 1.2 -0.7 1.0 -0.3 1.2 0.8 0.7 1.0
Age when periods started (menarche) 0.7 1.6 3.2 0.6 -1.8 -1.5 1.4 -1.8 -1.1 1.4 -0.3 0.0
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 3.1 -0.2 0.2 -1.4 -0.4 -0.2 -1.3 -1.4 -1.8 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 8.0 0.7 0.1 1.1 1.1 1.3 -2.8 -0.4 0.1 -0.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 -0.3 0.1 -0.7 0.2 -0.5 -0.6 0.2 -0.5 0.2
Qualifications: CSEs or equivalent 0.7 0.9 2.5 1.2 0.9 -1.2 -1.6 -0.2 0.7 -0.1 -1.1 0.0
Serious illness, injury or assault to yourself 1.4 1.7 4.0 0.6 1.4 1.1 -1.0 2.0 0.8 0.5 -1.9 -1.5
High blood pressure 0.6 1.7 8.3 -0.3 -0.1 0.4 -2.9 0.9 0.5 -1.4 -1.4 -1.3
Hayfever, allergic rhinitis or eczema 0.3 0.8 1.5 -0.9 -0.8 -0.9 0.5 -1.2 0.1 1.1 1.0 0.7
Multivitamins +/- minerals 0.5 0.7 3.0 1.0 -1.7 -0.0 -0.2 -1.0 0.3 0.7 0.1 0.6
Stomach or abdominal pain in last month 3.0 3.8 9.9 -0.8 -0.7 1.0 3.0 -0.0 -1.2 3.1 2.2 2.6
Supplements: Glucosamine 0.5 0.6 1.9 -0.4 0.2 -0.1 -1.3 0.1 1.2 -1.4 -0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 6.7 -1.0 0.2 -0.7 1.8 -0.5 -0.3 0.9 1.6 2.6
Medication: Atenolol 0.2 0.2 1.0 0.8 -1.0 -0.1 0.2 -0.0 -0.1 -0.1 0.3 0.1
Medication: Levothyroxine sodium 1.2 2.0 7.2 -0.6 0.3 1.8 1.2 1.3 -1.2 0.5 2.7 1.5
Sitting height 0.6 4.4 19.5 2.0 -0.0 -0.7 -0.5 0.2 -0.4 -2.6 -4.4 -2.9
Chronic bronchitis/emphysema (father) 1.5 1.8 7.3 -1.1 0.2 0.8 1.0 0.3 2.7 1.6 1.2 1.3
High blood pressure (mother) 0.3 0.5 1.3 0.0 -0.8 -0.8 -0.5 -1.1 -0.8 -0.5 0.1 0.8
Body mass index (BMI) 0.7 2.9 6.4 -2.5 -0.9 1.9 2.2 1.7 -0.2 1.0 2.3 1.2
Impedance of leg (left) 0.6 3.0 15.5 3.9 1.1 -0.9 0.9 -1.4 1.1 1.6 -0.6 1.7
Leg predicted mass (left) 0.6 3.1 6.7 -2.1 -1.4 1.3 -0.7 1.8 -0.9 -2.6 -1.5 -2.5
Trunk fat mass 0.1 0.6 1.4 -1.0 -0.8 0.8 1.2 1.2 0.2 -0.3 0.5 -0.2
Waist circumference 0.3 1.2 4.1 -2.0 -0.6 0.9 1.0 1.2 0.3 -1.5 0.5 -0.0
Number of incorrect matches in round 0.2 0.4 1.1 0.8 0.2 -1.0 -0.2 -0.5 0.3 1.0 0.4 -0.1
Past tobacco smoking 0.2 0.4 1.1 -0.2 -0.4 -0.4 -0.9 -0.5 0.2 -1.0 -0.8 -0.6
Alcohol usually taken with meals 0.9 1.5 4.9 2.2 0.3 -0.4 -2.0 0.8 -0.8 -0.5 -0.8 -1.5
Nervous feelings 0.5 1.0 3.9 0.4 0.7 -2.0 -0.1 -1.1 1.0 -1.5 0.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.5 1.2 0.7 -0.4 2.1 -0.5 0.4 0.8 0.9 2.1
Hearing difficulty/problems with background noise 2.0 3.1 10.0 0.6 -1.7 0.6 2.1 -0.6 0.8 2.3 2.0 3.2
Hair/balding pattern: Pattern 2 0.9 1.1 3.7 -0.3 -0.3 -1.9 1.2 -1.6 0.7 1.2 -0.5 -0.0
Had menopause 0.6 0.8 3.6 0.5 0.1 -0.8 -0.2 -0.7 -0.8 -1.9 -0.8 -0.8
Had other major operations 0.3 0.3 1.0 -0.8 -0.3 0.9 -0.2 1.0 -0.7 0.1 -0.0 0.2
Forced vital capacity (FVC) 0.5 1.9 7.4 1.8 -1.5 1.0 2.7 -0.0 0.1 1.0 -1.3 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 8.8 0.2 0.6 0.9 0.9 1.1 -3.0 -0.6 0.4 -0.1
Ever unenthusiastic/disinterested for a whole week 2.0 2.4 6.4 0.9 -1.1 -2.5 0.8 -2.5 1.5 1.0 -1.7 -0.5
Qualifications: None of the above 0.3 0.6 1.3 -0.2 1.0 0.0 0.9 0.1 1.1 1.1 1.2 0.4
Financial difficulties in last 2 years 1.7 2.2 6.1 -1.1 1.2 0.2 2.2 0.2 -1.4 1.5 1.6 2.5
Mouth/teeth dental problems 2.0 3.1 10.7 1.1 1.1 -0.3 -2.1 0.9 -0.6 -0.9 -2.9 -3.3
Heart attack 0.6 0.7 3.0 0.3 1.0 1.4 -0.4 1.7 0.4 -0.2 -0.2 -0.1
Allergy 0.4 1.0 2.2 1.1 -0.1 1.5 -0.5 1.3 -0.7 -0.7 -0.9 -1.3
Pain all over the body in last month 0.3 0.3 1.4 0.5 -0.4 -0.5 -0.5 -0.4 0.2 -0.8 -1.2 0.3
Diabetes (self-reported) 0.3 0.4 1.1 -0.5 -0.6 0.5 -0.6 1.0 1.1 0.4 0.3 -0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.6 0.6 -0.3 -0.7 0.5 -0.8 -0.3 -0.3 -0.1 0.6
Medication: Ramipril 0.2 0.3 0.7 -0.8 0.0 0.6 -0.2 0.8 0.4 -0.5 0.2 0.6
Medication: Simvastatin 0.4 0.6 1.8 -0.7 1.0 0.1 -0.8 0.7 1.3 0.5 0.4 -0.8
Fluid intelligence score 0.7 1.4 3.5 0.1 -1.9 -0.6 -0.1 -1.2 -1.7 -1.3 -1.4 -0.9
Illnesses of siblings 1.0 1.4 5.9 -0.9 0.9 2.4 0.2 1.9 0.1 0.5 1.2 0.0
Neuroticism score 0.3 0.5 1.6 1.0 -0.4 -1.0 1.3 -0.1 0.5 -0.4 -0.8 0.4
Weight 0.3 1.4 2.6 -1.3 -1.1 1.0 0.7 1.6 -0.2 -1.6 -0.9 -1.4
Impedance of arm (right) 0.4 1.8 9.0 3.0 1.0 -1.8 -1.1 -1.1 0.5 0.2 -0.7 -0.1
Arm fat percentage (right) 0.5 1.9 4.8 -1.6 -0.4 1.1 1.8 1.4 0.4 1.0 2.2 1.3
Trunk fat-free mass 0.9 5.4 15.7 -1.9 -0.9 1.0 -0.9 1.7 -0.2 -4.0 -3.0 -3.9
Hip circumference 0.2 1.1 2.7 -1.6 -0.7 1.4 0.8 1.6 -0.4 -0.7 0.5 -0.3
Time employed in main current job 0.9 1.1 2.7 0.1 0.3 0.8 0.7 1.1 0.9 1.6 1.6 1.1
Alcohol intake versus 10 years previously 1.0 1.5 8.1 -0.5 0.4 0.8 1.8 0.8 -2.9 0.0 0.1 -0.3
Father’s age at death 0.4 0.5 2.3 1.4 -0.2 0.3 -0.3 0.4 1.5 0.0 0.6 0.1
Worrier / anxious feelings 1.6 3.0 8.7 0.9 -1.7 -2.9 0.3 -2.2 0.5 -1.9 -2.2 -0.9
Frequency of tiredness / lethargy in last 2 weeks 1.8 2.9 11.9 -0.0 0.5 0.6 3.5 0.1 1.0 2.0 1.2 2.7
Falls in the last year 0.9 1.2 5.2 -0.6 0.7 -0.6 -0.7 -0.1 2.3 -1.5 -1.1 -0.6
Hair/balding pattern: Pattern 3 1.0 1.4 3.1 -0.3 0.8 1.6 -1.8 1.8 -1.3 -1.0 0.7 -0.3
Number of live births 0.7 1.0 2.6 -1.2 0.1 1.2 -1.3 0.9 0.9 -1.6 0.0 -0.4
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 8.6 1.7 -2.5 1.3 2.9 -0.1 0.1 1.6 -0.8 0.8
Pulse rate 0.4 0.7 3.0 -0.4 0.9 -0.7 0.0 -0.5 0.1 0.7 1.7 1.0
Happiness 1.7 2.1 7.6 1.3 -1.0 -2.7 0.2 -2.7 -0.2 0.1 -1.0 0.0
Noisy workplace 0.5 0.6 1.6 0.9 1.3 0.8 0.4 1.1 0.7 -0.1 0.7 0.3
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.0 0.1 -1.7 -0.9 -1.1 -1.1 -0.5 -1.1 -1.7 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.9 1.0 0.2 0.8 -0.1 0.7 -0.0 -0.1 -0.8 -0.4
Mouth/teeth dental problems: Dentures 1.2 2.0 3.9 -1.6 -0.4 -1.5 1.2 -2.0 1.1 -0.5 1.8 1.7
Asthma 0.4 0.8 1.8 0.6 1.1 -0.6 1.2 -0.4 -0.6 1.3 0.4 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.6 4.8 0.2 0.2 2.2 1.8 1.3 1.1 1.6 0.2 0.7
Medication: Cholesterol lowering 1.3 2.1 7.3 0.3 1.3 0.2 -2.7 1.5 2.1 -1.0 -0.7 -1.1
Depression (self-reported) 1.0 1.2 3.5 1.7 1.2 0.2 0.6 0.6 0.0 -1.9 -1.2 -0.7
Medication: Lansoprazole 0.1 0.2 0.7 0.4 0.1 0.2 0.9 0.4 0.3 -0.2 -0.2 0.2
Prospective memory result 0.4 0.5 1.5 -0.3 1.2 -0.1 0.5 0.1 0.6 -0.3 0.6 1.1
Lung cancer (father) 0.4 0.4 1.9 -0.3 -0.0 0.0 0.9 -0.1 -1.4 -0.2 0.8 0.6
Illnesses of mother 1.0 1.2 3.2 -0.5 0.7 1.8 1.6 1.3 -0.8 1.4 0.7 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 8.1 1.6 -2.5 1.5 2.8 0.2 -0.9 1.3 -0.3 1.3
Pulse wave Arterial Stiffness index 0.7 0.8 2.1 0.3 -0.9 1.0 1.2 0.4 0.7 0.9 0.5 1.4
Impedance of arm (left) 0.4 1.9 11.0 3.3 0.5 -1.6 -0.8 -1.2 0.1 0.5 -0.5 0.3
Arm fat mass (right) 0.3 1.3 3.5 -1.9 -0.5 1.3 1.5 1.7 0.0 -0.0 1.1 0.1
Trunk predicted mass 1.0 5.4 15.8 -1.9 -0.9 1.0 -1.0 1.6 -0.2 -3.9 -3.0 -4.0
Standing height 1.4 13.9 42.9 2.1 -0.8 -1.3 -3.1 0.1 0.1 -5.7 -6.5 -5.8
Length of working week for main job 1.1 1.2 9.3 0.2 -0.4 -0.1 0.9 -0.5 -3.0 0.7 -0.1 0.0
Exposure to tobacco smoke at home 0.6 0.7 2.8 0.1 0.1 -1.0 -1.7 0.4 1.3 -0.2 -0.5 -0.8
Breastfed as a baby 0.6 0.7 3.6 -1.9 -0.4 0.2 0.4 -0.6 -0.8 0.5 1.1 0.1
Tense / ‘highly strung’ 0.9 1.4 7.4 1.4 0.2 -2.7 -0.2 -1.6 -0.1 -0.4 -0.7 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.2 0.5 0.1 1.0 0.7 1.1 0.2 -0.5 0.3 1.0
Hair/balding pattern: Pattern 4 0.5 1.3 4.5 0.3 -1.4 0.3 -0.6 0.3 2.1 0.0 -1.1 -1.9
Birth weight of first child 0.4 0.7 2.5 0.3 -1.3 -0.1 0.9 -0.2 0.6 0.2 0.7 1.6
Peak expiratory flow (PEF) 1.0 2.4 12.2 0.4 -1.3 1.7 3.5 0.5 0.5 1.6 0.1 1.3
Pulse wave reflection index 0.3 0.4 1.1 -0.1 0.1 1.0 1.0 0.4 0.4 0.8 -0.0 0.8
Ever highly irritable/argumentative for 2 days 1.1 1.4 4.1 0.0 0.4 -0.6 1.7 -0.5 -0.6 2.0 0.9 1.8
Loud music exposure frequency 1.0 1.1 4.0 -0.8 -0.6 -1.6 0.9 -2.0 0.4 0.6 0.4 0.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.9 0.8 -1.0 0.4 -1.3 0.8 0.4 -0.7 -0.7 -1.4
Mouth/teeth dental problems: Bleeding gums 1.4 1.9 4.8 -1.0 -2.0 0.2 1.6 -1.0 0.2 1.3 1.3 2.2
Blood clot in the leg (DVT) 0.6 0.7 2.1 -1.4 0.2 1.0 -0.8 1.4 0.4 -0.8 -0.1 0.4
Medication: Paracetamol 0.7 1.2 3.3 -0.8 -0.2 0.6 1.8 0.4 1.2 1.6 0.7 1.4
Headache pain in last month 1.0 1.8 4.7 1.3 -0.6 0.8 2.0 0.3 -0.4 1.9 0.6 2.2
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 11.8 -1.0 -1.3 -0.6 3.4 -2.0 -2.2 1.9 0.7 0.8
Glaucoma (self-reported) 0.5 0.6 2.1 -0.2 0.6 -0.2 -0.7 0.5 1.4 0.3 1.0 0.9
Gout (self-reported) 1.1 1.6 7.2 0.9 0.4 -0.5 -0.5 1.0 -0.0 -1.1 -1.8 -2.7
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 6.1 -0.4 1.5 1.4 0.4 1.6 -1.1 -0.4 2.5 1.0
Medication: Amlodipine 0.6 0.8 2.8 -0.1 0.8 -0.2 -1.1 0.5 -0.2 0.5 -1.7 -1.4
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.7 0.3 0.1 -1.3 0.0 -1.2 0.3 1.2 -1.1 0.7
Birth weight 0.2 0.5 2.4 -0.4 -0.8 -0.4 0.5 -0.7 1.6 0.1 0.1 0.0
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.7 0.1 -0.3 0.4 -0.2 0.4 1.1 -0.4 1.1 1.3
High blood pressure (siblings) 0.6 0.9 1.9 1.4 -0.8 -0.5 -0.8 0.4 -0.6 -1.2 -1.3 -1.2
Forced vital capacity (FVC), Best measure 0.5 1.9 8.5 1.2 -2.0 1.1 2.9 -0.0 -0.6 1.0 -0.6 0.9
Body fat percentage 0.4 1.5 4.0 -0.8 -0.5 1.0 2.0 1.1 0.4 1.2 1.8 1.4
Leg fat percentage (right) 1.1 4.1 12.8 -1.0 -0.7 1.2 3.6 0.7 0.5 2.3 2.6 2.9
Arm fat-free mass (right) 0.6 2.8 7.0 -1.5 -1.5 1.1 0.0 1.3 -0.5 -2.6 -2.1 -2.5
Exposure to tobacco smoke outside home 1.5 1.9 7.7 -2.8 0.5 -1.4 0.1 -1.2 1.7 -1.8 0.1 -0.1
Comparative body size at age 10 1.3 3.5 7.6 -0.9 1.3 2.6 1.6 2.8 0.9 1.6 2.7 1.1
Number of full brothers 1.4 1.7 3.6 -1.9 -0.8 -0.4 1.1 -0.7 -1.4 1.2 1.8 1.6
Worry too long after embarrassment 0.8 1.4 4.5 1.0 -0.4 -0.9 -0.7 0.3 0.1 -2.1 -2.0 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 -0.2 0.8 -0.7 0.7 -0.4 0.1 -0.6 -0.4 -0.6
Wheeze or whistling in the chest in last year 1.0 1.9 7.8 -0.2 -0.6 -0.1 2.8 -1.1 0.9 0.7 1.1 2.2
Number of children fathered 0.7 0.8 3.8 1.0 -2.0 0.9 -0.1 0.4 -0.7 1.1 0.2 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 3.7 -0.5 0.1 -0.6 -1.3 0.1 -0.6 -1.4 -1.2 -1.9
Age at first live birth 0.5 0.9 2.0 0.4 -1.4 1.0 -0.3 -0.2 1.4 0.7 -0.9 -1.2
Pulse wave peak to peak time 0.9 1.1 2.8 -0.2 0.7 -1.2 -1.5 -0.5 -0.6 -1.2 -0.8 -1.7
Health satisfaction 1.3 1.6 3.9 0.2 -1.5 -1.7 1.1 -1.8 0.6 0.8 0.3 2.0
Shortness of breath walking on level ground 0.8 0.9 3.4 0.3 0.3 -1.9 1.4 -1.3 0.1 -0.2 -0.8 0.4
Qualifications: College or University degree 0.5 1.6 10.1 0.6 -0.5 0.6 -0.4 0.3 -3.2 -1.3 -1.1 -0.7
Eye problems/disorders: None of the above 0.9 1.0 4.5 -0.7 -1.3 0.5 2.1 -0.7 0.4 1.1 0.6 0.4
Mouth/teeth dental problems: Loose teeth 2.2 2.6 5.3 1.2 -1.3 1.5 2.1 0.6 0.6 2.3 2.0 1.9
Emphysema/chronic bronchitis 0.6 0.7 2.7 -0.7 -0.6 -0.1 0.9 -1.2 1.6 -0.1 0.5 0.6
Medication for pain relief, constipation, heartburn 2.1 3.7 18.2 -0.5 -0.4 -1.7 -1.0 -1.2 -4.3 -2.3 -0.8 -1.9
Neck or shoulder pain in last month 3.8 5.4 12.8 -1.8 0.4 -0.8 2.8 -1.6 2.3 3.6 2.8 2.9
Medication: Blood pressure 1.5 2.6 8.7 1.0 0.7 0.3 -3.0 1.6 2.3 -2.0 -0.8 -0.6
Angina (self-reported) 0.9 1.1 3.6 0.9 -1.0 -0.3 0.5 -0.3 1.6 1.3 0.2 1.9
Migraine (self-reported) 0.4 0.5 2.5 0.3 -1.6 1.1 0.4 0.3 -0.2 0.8 -0.4 0.0
Medication: Ibuprofen 1.3 1.6 5.3 0.5 0.2 2.3 1.6 1.2 0.9 1.6 0.1 1.1
Medication: Allopurinol 1.5 2.0 7.9 0.4 0.6 -0.7 -1.4 0.6 0.1 -1.4 -2.1 -2.8
Medication: Omeprazole 0.8 1.0 4.6 0.6 -0.2 0.4 1.0 0.2 2.2 0.4 0.9 1.3
Medication: Seretide 50 evohaler 0.5 0.6 2.2 -0.6 -0.0 -0.3 -0.9 0.7 1.0 -0.6 -0.7 -1.5
Mean time to correctly identify matches 0.6 1.1 4.0 -0.1 -0.7 -2.0 0.5 -1.6 0.9 -0.4 -1.0 1.0
Heart disease (mother) 0.7 0.9 2.5 0.7 -1.0 -1.5 -0.5 -1.0 1.6 -0.6 0.1 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 16.2 -1.7 0.7 1.3 1.5 0.5 1.3 2.5 4.0 2.7
Whole body fat mass 0.2 0.8 2.0 -1.4 -0.8 0.9 1.4 1.2 0.2 -0.1 0.8 -0.0
Leg fat mass (right) 0.4 1.7 4.7 -1.5 -0.9 1.4 2.2 1.4 0.3 0.6 1.4 0.8
Arm predicted mass (right) 0.7 3.4 8.1 -1.5 -1.4 1.4 -0.3 1.6 -0.3 -2.9 -2.5 -2.7
Pulse rate, automated reading 0.7 2.2 8.6 -0.5 0.5 -0.1 0.3 -0.2 1.6 0.3 2.8 2.9
Alcohol intake frequency. 0.7 1.5 7.9 2.2 0.3 -0.4 0.4 0.4 -2.8 -0.6 -0.0 -0.1
Comparative height size at age 10 1.3 7.0 20.7 1.4 -0.2 -0.9 -2.1 -0.3 0.7 -4.5 -4.4 -3.9
Number of full sisters 0.5 0.6 1.7 0.7 0.8 1.3 -0.6 1.2 0.5 -0.2 0.9 -0.0
Suffer from ‘nerves’ 1.2 1.9 8.1 0.6 -0.4 -2.8 1.2 -2.0 -0.2 -0.0 1.2 1.2
Overall health rating 0.2 0.5 1.9 -0.9 0.5 -0.2 1.4 0.2 0.8 0.1 0.9 0.7
Chest pain or discomfort 1.9 2.7 7.9 0.2 0.1 -0.3 2.7 -0.6 0.3 2.3 1.7 2.8
Had major operations 0.2 0.3 1.3 -0.4 -0.1 0.3 -0.2 0.8 -0.2 0.3 0.1 -1.1
Age at last live birth 0.6 0.8 1.6 -1.2 -1.1 0.8 -0.7 0.2 1.2 0.3 -0.7 -1.2
Family relationship satisfaction 2.0 2.4 8.1 -0.6 0.6 -2.9 1.2 -2.7 -0.7 1.2 0.9 1.2
Leg pain on walking 0.5 0.6 2.4 -0.3 -0.6 -1.6 0.3 -0.6 1.2 0.8 0.1 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.4 0.9 -1.0 -0.4 1.2 -0.8 -0.3 1.1 -0.2 0.2
Commuting to job workplace: Car/motor vehicle 1.2 1.4 4.2 -0.2 1.9 1.9 -0.4 2.0 -0.3 -0.2 1.1 -0.1
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.5 -0.1 -1.1 -1.2 -0.9 -1.2 -0.5 -0.9 -0.5 -1.0
Medication: Aspirin 1.2 1.6 5.9 1.1 -0.5 0.8 -2.4 0.6 2.4 0.2 -0.4 0.3
Supplements: Vitamin C 0.8 0.9 1.8 -0.6 1.4 -1.1 -1.1 -1.1 -0.4 -1.3 0.3 0.2
Knee pain experienced in last month 1.7 2.7 8.2 -0.2 -0.2 -1.2 2.1 -1.5 2.1 1.6 0.8 2.9
Hypertension (Self-reported) 0.6 1.5 6.6 -0.1 -0.0 0.1 -2.6 0.9 0.9 -1.1 -1.6 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.5 -0.1 -1.6 -1.0 -0.1 -1.0 0.6 1.0 -0.9 0.1
Illnesses of father: Heart disease 0.4 0.6 4.1 0.1 -0.7 0.4 -0.2 0.4 2.0 0.1 0.5 0.4
Illnesses of siblings: Diabetes 1.0 1.2 2.4 -0.4 -1.3 -1.5 1.3 -1.5 -0.0 1.3 -0.3 0.9
Smoking status: Previous 0.1 0.2 0.4 0.3 -0.1 0.4 0.1 0.5 -0.6 0.6 0.4 0.0
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 5.8 1.8 -1.2 1.5 -0.3 1.4 -0.5 -2.4 -1.9 -1.6
Whole body fat-free mass 0.8 4.4 11.4 -2.0 -1.2 1.2 -0.8 1.8 -0.6 -3.4 -2.4 -3.4
Leg fat-free mass (right) 0.7 3.6 9.2 -1.7 -1.2 1.0 -1.0 1.6 -1.3 -2.9 -2.1 -3.0
Arm fat percentage (left) 0.6 2.3 6.6 -1.4 -0.6 1.2 2.0 1.4 0.1 1.3 2.6 1.7
Average weekly red wine intake 0.9 1.3 7.2 -0.4 -2.7 -0.6 -1.1 -1.6 -0.6 0.1 -0.3 0.0
Handedness (chirality/laterality): Left-handed 0.2 0.3 1.1 0.2 1.1 0.4 -0.3 0.6 0.5 0.6 0.4 0.2
Mood swings 1.4 2.6 10.2 0.1 -0.7 -0.9 3.2 -1.4 1.2 1.5 0.3 2.5
Loneliness, isolation 0.4 0.6 2.8 0.7 -0.1 -0.9 0.4 -0.3 0.1 1.7 0.5 0.9
Long-standing illness, disability or infirmity 0.3 0.5 2.5 -0.1 1.6 0.2 0.9 0.4 1.0 0.2 0.0 0.3
Ever had bowel cancer screening 1.3 1.5 2.9 -1.4 -0.6 -0.8 -1.6 -0.7 -0.4 -1.7 -1.4 -1.7
Diabetes diagnosed by doctor 0.2 0.4 1.3 -0.9 0.0 0.7 -0.3 1.1 0.4 -0.1 0.9 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 3.3 -0.1 -1.8 0.8 -0.3 -0.2 1.2 -0.2 0.5 0.6
Friendships satisfaction 0.5 0.6 2.7 0.2 -0.3 -0.6 0.4 -0.5 -1.6 0.2 0.8 1.0
Qualifications: nursing, teaching 0.3 0.5 0.9 -0.5 -0.5 -0.6 -0.7 -1.0 -0.8 -0.8 -0.1 -0.8
Commuting to job workplace: Walk 1.8 1.9 5.0 0.7 -1.8 -2.2 -1.1 -2.2 0.7 -0.2 -1.0 -0.9
Eye problems/disorders: Cataract 0.6 0.7 2.7 -0.8 0.8 0.0 -1.6 0.1 -0.9 -1.4 -0.2 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.2 0.7 -0.2 0.2 0.5 0.4 0.5 0.2 -0.2 1.1
Medication for cholesterol 0.1 0.2 0.7 0.0 -0.7 -0.0 -0.2 -0.5 0.2 0.8 0.2 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 4.2 -2.1 -0.1 0.9 1.1 1.2 1.8 1.0 0.7 0.5
Back pain experienced in last month 0.3 0.5 1.6 0.4 0.4 -0.1 1.3 -0.7 -0.7 0.5 0.7 0.8
Mineral and other dietary supplements 0.7 0.9 2.9 -0.6 0.5 0.2 1.7 0.2 -1.5 1.4 0.6 0.2
Breast cancer (self-reported) 0.4 0.5 2.1 -1.0 -0.0 0.0 0.2 -0.4 -0.9 0.3 1.4 0.5
Asthma (self-reported) 0.4 0.9 2.2 0.7 1.0 -0.7 1.2 -0.4 -0.3 1.3 0.5 1.5
Osteoporosis (self-reported) 1.1 1.3 3.0 -1.3 0.5 -0.7 1.3 -1.0 1.4 1.7 0.6 1.3
Osteoarthritis (self-reported) 1.0 1.2 4.0 -0.7 1.7 0.0 -0.6 0.9 1.5 -2.0 -0.4 -0.4
Medication: Aspirin 1.2 1.5 6.2 1.2 -0.6 0.9 -2.5 0.5 2.1 0.1 -0.4 0.4
Medication: Gliclazide 0.6 0.7 1.9 1.4 -1.1 0.6 0.5 0.6 1.0 0.5 0.5 -0.2
Illnesses of father: None of the above (group 1) 1.2 1.5 8.4 -0.1 0.3 -1.2 0.9 -0.6 -2.9 -0.2 -0.3 -1.3
Smoking status: Current 0.3 0.5 2.5 -0.2 0.7 -0.2 1.6 0.2 0.3 -0.7 0.7 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.6 7.3 -0.2 -2.7 0.7 2.7 -0.9 0.5 1.4 0.9 2.2
Whole body water mass 0.8 4.3 11.4 -2.0 -1.2 1.2 -0.8 1.7 -0.5 -3.4 -2.4 -3.3
Leg predicted mass (right) 0.7 3.6 8.9 -1.7 -1.2 1.1 -1.0 1.7 -1.4 -2.9 -1.9 -3.0
Arm fat mass (left) 0.3 1.3 3.2 -1.8 -0.6 1.3 1.4 1.7 -0.0 0.1 1.2 0.1
Number of self-reported non-cancer illnesses 0.5 0.8 3.3 -0.8 1.8 -0.5 -0.3 0.7 0.6 -1.3 -0.9 -0.2
Average weekly champagne plus white wine intake 0.3 0.4 1.5 0.0 -0.4 0.5 -0.8 1.0 -1.2 -0.3 -0.1 -0.5
Miserableness 0.4 0.7 2.8 0.6 -1.3 0.0 1.7 -0.4 -0.4 -0.1 -0.3 1.0
Guilty feelings 1.2 1.8 9.1 1.6 -1.2 0.5 0.2 0.8 1.4 -0.5 -3.0 -0.2
Wears glasses or contact lenses 1.0 1.1 2.4 -0.6 0.6 -1.5 -0.4 -1.1 -1.5 -0.9 -0.7 -1.4
Ever taken oral contraceptive pill 0.6 0.7 2.8 -0.5 0.7 -0.5 -1.1 0.2 1.0 -1.7 0.1 0.2
Hearing aid user 0.7 0.8 3.0 -0.7 -1.1 -0.5 1.7 -0.9 -0.0 0.8 0.7 0.2
Mother’s age at death 2.5 3.2 6.7 2.3 0.4 -2.6 -1.3 -1.6 -0.9 -1.7 -2.3 -1.8
Financial situation satisfaction 0.4 0.6 1.5 0.1 -0.4 -0.5 1.2 -1.2 -0.4 0.0 -0.5 1.1
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.3 -1.3 0.8 -0.2 1.7 -0.4 0.7 0.8 1.8 1.3
Commuting to job workplace: Public transport 0.3 0.4 1.6 -0.8 1.3 -0.2 0.0 -0.1 0.2 -0.3 0.5 0.8
Eye problems/disorders: Glaucoma 0.5 0.6 2.1 -0.6 0.3 -0.3 0.1 0.1 0.9 0.9 1.4 1.1
Medication: Blood pressure 0.0 0.0 0.1 -0.1 -0.3 0.1 -0.2 0.2 -0.2 -0.1 -0.2 0.1
Pain type(s) experienced in last month: Hip pain 0.9 1.2 4.5 -2.1 1.1 0.8 0.6 0.6 1.1 0.5 1.2 0.7
Supplements: Fish oil (including cod liver oil) 1.1 1.5 4.4 -0.3 -0.3 -0.2 -2.1 0.2 1.7 -1.8 -1.1 -1.2
High cholesterol (Self-reported) 0.2 0.4 1.3 -0.1 1.0 0.4 -0.8 0.8 1.1 -0.2 -0.2 -0.1
Medication: Bendroflumethiazide 1.2 1.9 4.4 0.1 -0.8 -2.0 -1.9 -1.0 0.7 -1.3 -2.1 -1.1
Medication: Paracetamol 1.2 1.8 3.8 -0.8 0.0 0.7 1.7 0.4 1.8 1.9 1.4 2.0
Medication: Lisinopril 0.7 0.9 2.4 1.4 1.4 -0.5 -1.5 0.3 1.2 -0.2 -0.1 0.3
Medication: Atorvastatin 0.9 1.1 3.1 -1.0 -0.3 0.1 -1.4 0.5 0.4 -1.8 -1.1 -1.4
Illnesses of father: High blood pressure 1.4 1.7 4.5 0.5 1.7 2.1 -1.7 1.7 0.8 0.2 0.8 0.6
Alcohol drinker status: Never 0.6 0.7 3.9 -0.6 -2.0 -0.3 -0.4 -0.0 0.1 -0.7 -0.3 -1.1
Ever smoked 0.8 1.4 4.4 -0.2 0.6 0.4 2.1 0.3 -0.0 1.8 1.4 1.5
Basal metabolic rate 0.7 3.6 9.0 -1.8 -1.2 1.3 -0.4 1.9 -0.6 -3.0 -2.1 -3.0
Leg fat percentage (left) 0.8 2.9 8.6 -0.5 -0.4 1.1 2.9 0.8 0.2 2.0 2.3 2.3
Arm fat-free mass (left) 0.7 3.4 8.5 -1.8 -1.1 1.1 -0.3 1.6 -0.2 -2.9 -2.4 -2.9
Number of operations (self-reported) 0.1 0.2 0.5 0.4 0.7 -0.4 -0.4 0.1 -0.5 0.6 0.1 0.1
Average weekly beer plus cider intake 0.9 1.3 4.6 -1.4 0.0 -0.6 2.1 -0.5 -0.3 0.2 1.7 1.2
Irritability 0.4 0.8 1.8 -0.6 1.1 -0.7 1.3 -0.2 0.3 -1.0 -0.1 1.3
Risk taking 2.4 3.5 11.6 -0.1 0.5 3.4 1.0 3.2 1.2 2.0 1.7 0.4
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.4 -0.4 -1.2 -0.4 0.2 -0.4 0.5 0.7 0.3 0.1
Fractured/broken bones in last 5 years 1.4 1.8 3.6 -1.6 1.4 -1.1 -1.9 -0.2 0.2 -1.7 -0.9 -1.8
Age started oral contraceptive pill 1.0 1.2 5.0 -0.1 1.0 -2.2 0.4 -1.4 0.6 -1.4 -0.6 -0.2
Diastolic blood pressure, automated reading 0.2 0.7 2.5 -1.6 -1.0 0.6 0.2 0.2 0.8 0.2 1.2 0.9
Ever depressed for a whole week 0.6 0.7 2.0 0.1 -0.5 -0.8 0.3 -1.0 1.4 0.8 -1.2 -0.1
Unable to work because of sickness or disability 0.4 0.5 1.8 0.2 0.9 0.5 -0.1 0.8 1.4 -0.8 -0.6 -0.1
Commuting to job workplace: Cycle 2.2 2.7 11.4 2.0 -1.7 0.8 -1.0 0.7 -0.4 -1.0 -3.4 -1.7
Myopia 0.7 1.1 3.2 -1.2 0.3 -0.1 -0.2 0.5 1.8 1.0 1.4 -1.3
Vascular/heart problems diagnosed by doctor 0.6 1.6 7.9 -0.2 -0.2 -0.8 2.8 -1.5 -0.4 1.1 1.2 0.9
Cholesterol lowering medication 0.9 1.3 3.0 -1.2 -0.4 1.7 1.3 1.0 0.8 0.5 1.4 1.2
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 4.6 0.7 0.1 0.0 0.7 -0.1 2.2 0.4 1.2 1.3
Pain experienced in last month 3.7 6.2 15.9 1.2 1.4 0.5 -3.5 1.9 -1.4 -3.7 -2.2 -4.0
Supplements: Calcium 0.5 0.5 2.1 1.4 0.5 -0.5 -0.9 -0.5 0.7 0.4 0.1 0.7
Basal cell carcinoma (self-reported) 1.4 1.7 8.0 -0.7 0.5 0.5 -2.8 1.2 -0.2 -1.5 -0.5 -1.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.3 0.5 1.0 1.5 -0.5 1.8 0.2 -0.1 -0.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.3 -1.3 0.2 1.1 -0.9 1.5 0.6 -0.8 -0.3 0.2
Heart disease (siblings) 1.2 1.4 3.2 1.8 -0.9 -1.8 -0.2 -1.6 0.8 -0.6 -0.5 1.2
Alcohol drinker status: Previous 0.5 0.6 2.0 1.2 1.4 -0.8 -0.2 -0.1 0.3 0.1 -0.5 0.8
Pack years of smoking 0.5 0.7 3.4 -0.8 0.7 -0.4 1.8 0.1 0.3 -0.4 0.9 0.4
Impedance of whole body 0.5 2.4 14.3 3.8 0.9 -1.3 -0.1 -1.3 0.7 1.2 -0.4 1.2
Leg fat mass (left) 0.3 1.3 3.0 -1.3 -0.6 1.5 1.7 1.6 0.0 0.4 1.1 0.4
Arm predicted mass (left) 0.7 3.7 9.6 -1.7 -1.1 1.2 -0.6 1.7 -0.1 -3.1 -2.5 -3.0