[Hub]/) : Traits : HDL Cholesterol : ← →

chr1:39,182,130-40,737,589

Best TWAS P=5.46e-11 · Best GWAS P=3.99e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BMP8A	0.05	0.03	lasso	3	0.02	8.8e-04	-6.25	-6.4	1.8e-10	1.00	0.02	0.97	FALSE
2	GTEx	Adipose Subcutaneous	PABPC4	0.15	0.04	lasso	8	0.04	3.3e-04	-4.87	6.1	1.2e-09	-0.85	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	RP11-69E11.4	0.14	0.08	enet	22	0.10	1.4e-08	-6.03	-5.2	2.0e-07	0.84	0.03	0.97	FALSE
4	GTEx	Adrenal Gland	PABPC4	0.20	0.09	lasso	8	0.06	3.0e-03	-6.03	6.4	1.6e-10	-0.93	0.02	0.91	FALSE
5	GTEx	Artery Aorta	RP11-69E11.4	0.13	0.10	enet	14	0.14	2.5e-08	-6.25	-5.4	7.8e-08	0.87	0.02	0.98	FALSE
6	GTEx	Artery Tibial	PABPC4	0.10	0.10	lasso	4	0.10	3.4e-08	-6.03	6.2	4.8e-10	-0.97	0.02	0.98	FALSE
7	GTEx	Artery Tibial	RP11-69E11.8	0.05	0.02	lasso	2	0.02	6.3e-03	-5.29	5.8	6.2e-09	-0.48	0.06	0.78	FALSE
8	GTEx	Breast Mammary Tissue	PABPC4	0.13	0.02	enet	14	0.04	3.4e-03	-6.25	5.8	7.9e-09	-0.93	0.02	0.94	FALSE
9	GTEx	Breast Mammary Tissue	RP11-69E11.4	0.15	0.05	enet	32	0.05	8.8e-04	-5.40	-5.4	7.5e-08	0.63	0.30	0.65	FALSE
10	GTEx	Cells Transformed fibroblasts	PABPC4	0.07	0.09	lasso	1	0.06	2.7e-05	-6.03	6.0	1.6e-09	-0.98	0.02	0.98	FALSE
11	GTEx	Colon Transverse	RP11-69E11.4	0.23	0.12	lasso	4	0.15	1.8e-07	-6.25	-5.4	6.5e-08	0.90	0.02	0.98	FALSE
12	GTEx	Esophagus Mucosa	PABPC4	0.06	0.06	lasso	3	0.08	7.3e-06	-6.25	6.5	9.6e-11	-0.99	0.01	0.99	FALSE
13	GTEx	Esophagus Mucosa	BMP8A	0.08	0.02	lasso	2	0.01	1.4e-01	3.32	-5.9	4.2e-09	0.65	0.04	0.94	FALSE
14	GTEx	Lung	PABPC4	0.05	0.03	lasso	3	0.02	1.3e-02	-6.03	5.5	3.7e-08	-0.94	0.06	0.86	FALSE
15	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	-6.03	5.4	8.1e-08	-0.85	0.02	0.98	FALSE
16	GTEx	Nerve Tibial	RP11-69E11.4	0.18	0.08	lasso	5	0.18	1.3e-12	-2.71	-5.4	8.8e-08	0.87	0.10	0.90	FALSE
17	GTEx	Nerve Tibial	RP11-69E11.8	0.05	0.00	lasso	3	0.01	6.9e-02	-6.03	6.3	3.6e-10	-0.97	0.03	0.88	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	PABPC4	0.12	0.10	lasso	3	0.05	1.0e-03	-6.25	6.3	2.6e-10	-0.99	0.01	0.97	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	RP11-69E11.4	0.16	0.18	lasso	3	0.15	1.0e-08	-5.10	-5.3	9.5e-08	0.67	0.82	0.17	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PABPC4	0.11	0.09	lasso	7	0.08	2.7e-07	-6.25	6.6	5.5e-11	-0.97	0.01	0.99	TRUE
21	GTEx	Spleen	BMP8A	0.16	0.08	lasso	3	0.05	1.6e-02	-5.29	-5.2	2.6e-07	0.56	0.07	0.33	FALSE
22	METSIM	Adipose	PABPC4	0.05	0.02	lasso	6	0.03	6.0e-05	-6.25	6.2	4.2e-10	-0.91	0.02	0.98	FALSE
23	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	0.72	-5.1	2.9e-07	0.52	0.04	0.90	FALSE
24	YFS	Blood	PABPC4	0.04	0.03	enet	44	0.03	3.2e-11	-6.25	6.3	2.3e-10	-0.85	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPC4	0.03	0.01	enet	4	0.02	4.3e-03	-6.03	6.0	1.7e-09	-0.98	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PABPC4	0.05	0.05	enet	4	0.05	5.5e-04	-6.25	5.7	1.2e-08	-0.95	0.00	0.97	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	BMP8A	0.05	0.01	blup	48	0.04	6.8e-05	-6.54	-5.4	7.1e-08	0.83	0.00	0.98	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	PABPC4	0.04	0.03	enet	8	0.04	4.5e-05	-6.25	5.6	1.8e-08	-0.93	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	BMP8A	0.05	0.05	enet	6	0.04	9.1e-05	-5.12	-5.3	1.4e-07	0.65	0.52	0.38	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	PABPC4	0.09	0.07	enet	5	0.08	4.1e-08	-6.03	5.9	3.6e-09	-0.86	0.00	1.00	FALSE