Hub : Genes

RP11-69E11.8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0493	0.0246	0.0080	0.018	NA	0.015	NA	0.023	0.013	NA	0.024	NA	0.0063
2	GTEx	Breast Mammary Tissue (Female)	0.1136	0.0890	0.0960	0.006	NA	0.005	NA	0.058	0.200	NA	0.230	NA	0.0082
3	GTEx	Nerve Tibial	0.0487	0.0223	0.0058	0.004	NA	-0.004	NA	0.009	0.150	NA	0.860	NA	0.0690

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.2	1.9	3.0	-1.2	1.1	-1.7
Bipolar Disorder or Schizophrenia	0.7	1.8	2.1	-1.3	1.5	-1.2
Depressed Affect (Nagel 2018)	0.7	1.4	4.0	0.3	-2.0	0.3
Depression (Nagel 2018)	0.5	0.8	0.9	-0.9	-0.9	-0.8
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.4	-1.9	0.6	-0.4
Neuroticism (Nagel 2018)	1.5	3.6	6.3	1.0	-2.5	1.9
Schizophrenia (2018)	0.2	0.5	0.9	-0.8	1.0	-0.1
Schizophrenia vs Biploar Disorder	3.6	4.7	8.6	2.9	-1.1	2.1
Worry (Nagel 2018)	0.4	0.9	2.0	0.4	-0.8	1.4
Alzheimer’s Disease (in mother)	0.5	0.5	1.5	1.2	0.0	-0.3
Alzheimer’s Disease (in father)	0.8	0.8	2.0	0.7	-1.4	0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.4	-0.8	-0.6
Crohns Disease (2017)	1.5	3.3	6.9	-1.4	-1.0	-2.6
Irritable Bowel Disease (IBD)	0.6	1.3	2.4	0.0	-1.2	-1.5
Ulcerative Colitis (UC)	0.5	1.0	2.0	1.4	-0.9	0.5
Major Depression (MDD)	0.2	0.2	0.3	-0.2	-0.6	-0.6
Reaction Time	1.4	2.6	3.9	2.0	0.4	1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	-1.2	-0.3	-0.6
Breast Cancer	1.4	3.4	4.1	1.7	-1.8	2.0
Ovarian Cancer	4.6	6.0	7.8	-2.8	-2.0	-2.5
Prostate Cancer	4.5	6.4	9.3	-2.8	1.4	-3.0
Age at First Birth	2.8	4.0	8.8	3.0	-1.0	1.5
Bipolar Disorder (2011)	1.4	1.4	2.3	-1.5	0.3	-1.3
Body Mass Index (BMI) (2010)	0.4	0.6	1.7	-0.2	-0.3	-1.3
Coronary Artery Disease (CAD)	0.9	1.0	2.0	-0.4	1.4	-1.0
Crohns Disease (2012)	2.9	4.7	9.4	-1.3	-1.7	-3.1
Mean Putamen Volume	0.3	0.3	1.0	0.2	1.0	0.1
Fasting Glucose	4.2	5.0	7.8	-2.8	-1.4	-2.3
HbA1C	2.2	2.5	5.4	-1.4	-0.4	-2.3
HDL Cholesterol	15.9	26.5	39.3	5.8	2.6	6.3
LDL Cholesterol	2.5	3.9	6.8	-1.1	-2.0	-2.6
Lupus	0.8	1.3	1.4	-1.1	1.1	-1.2
Neuroticism (2016)	0.8	1.1	1.3	1.1	-1.2	0.8
Primary Biliary Cirrhosis	0.5	0.7	1.5	0.7	-1.2	-0.2
Rheumatoid Arthritis	0.1	0.2	0.3	0.4	-0.0	0.5
Schizophrenia (2014)	0.4	0.8	1.6	0.6	0.7	1.3
Triglycerides	10.6	17.4	26.6	-5.2	-0.5	-5.0
Type 2 Diabetes (T2D) (2012)	4.2	4.8	9.3	-3.0	-1.2	-1.9
Ulcerative Colitis	0.2	0.3	0.7	0.5	-0.8	0.1
Blood Eosinophil Count	0.6	4.6	8.1	-2.3	-0.5	-2.9
Blood Platelet Count	0.8	8.8	14.1	-3.5	0.5	-3.8
Blood Red Count	1.0	9.4	20.9	-2.6	-0.8	-4.6
Blood White Count	0.9	6.4	11.9	-3.5	1.1	-2.5
Heel T-Score	1.4	10.9	22.4	-3.2	0.3	-4.7
BMI	3.7	21.5	50.0	-2.6	-2.8	-7.1
Height	0.6	11.4	14.9	-3.9	2.1	-3.9
Waist Hip Ratio (WHR)	1.3	5.7	8.4	-2.9	-0.8	-2.8
Systolic Blood Pressure	0.5	2.4	3.2	-1.8	1.8	-0.9
Smoking Status	0.4	1.1	1.5	-1.2	-0.6	-1.2
Allergy or Eczema	0.3	0.9	2.3	0.0	0.6	-1.5
Cardiovascular Disease	3.3	10.7	17.6	-3.8	-0.0	-4.2
Hypothyroidism (self reported)	1.8	4.1	8.2	1.9	-0.7	2.9
Respiratory disease	4.7	10.6	19.2	-3.5	-0.3	-4.4
Type 2 Diabetes (T2D) (2018)	10.9	20.4	41.1	-4.3	-1.0	-6.4
Lung FEV1/FVC ratio	7.7	38.8	82.3	5.8	0.4	9.1
Lung FVC	2.5	12.6	20.5	4.5	-1.7	3.8
Neuroticism	1.2	2.9	6.3	1.3	-2.5	0.9
Chronotype (morning person)	0.7	1.6	2.1	1.5	-0.9	1.4
Hair Pigment	0.4	10.4	20.3	-3.1	-1.1	-4.5
Tanning	0.5	5.9	11.3	1.6	1.9	3.4
Hand grip strength (left)	0.4	1.0	1.8	-0.4	-1.1	-1.3
Number of treatments/medications taken	2.5	4.6	8.8	-2.1	-0.8	-3.0
Average weekly spirits intake	0.3	0.4	0.7	0.2	-0.6	0.9
Sensitivity / hurt feelings	2.9	5.0	9.4	2.3	-3.1	0.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	-0.2	-0.3	-1.4
Hearing difficulty/problems: Yes	0.5	0.8	2.1	0.3	1.4	0.4
Relative age of first facial hair	0.2	0.4	0.8	-0.6	0.9	-0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.6	1.2	0.4	1.3
Ever used hormone-replacement therapy (HRT)	2.6	3.3	8.3	2.9	-0.2	1.3
Ever had hysterectomy (womb removed)	0.8	0.9	2.6	-0.3	1.6	0.3
Systolic blood pressure, automated reading	0.1	0.2	0.7	-0.0	0.8	0.0
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.7	-1.4	-1.4	-1.6
Angina	0.8	1.0	2.2	-0.1	1.5	-0.9
Medication for hormone replacement therapy	0.3	0.4	0.6	0.6	-0.4	-0.8
Vitamin and mineral supplements	0.3	0.4	0.7	0.8	-0.7	0.1
Supplements: Zinc	1.3	1.4	2.4	1.0	-0.8	1.6
Medication: Co-codamol	0.3	0.4	0.7	-0.0	0.6	-0.8
Medication: Metformin	6.0	8.4	15.7	-2.9	-1.0	-4.0
Diabetes (father)	1.8	2.3	4.9	-1.1	0.8	-2.2
Diabetes (mother)	7.1	9.0	16.0	-4.0	-0.4	-3.3
Severe depression (siblings)	0.3	0.3	0.4	0.6	-0.2	-0.6
Pack years adult smoking proportion	0.4	0.6	1.1	-0.9	0.3	-1.0
Impedance of leg (right)	4.4	21.4	56.7	2.0	1.9	7.5
Leg fat-free mass (left)	6.1	32.0	74.1	-4.7	-0.1	-8.6
Trunk fat percentage	2.7	10.8	22.7	-2.9	-1.0	-4.8
Hand grip strength (right)	0.7	1.8	2.9	-1.3	-0.9	-1.7
Townsend deprivation index at recruitment	1.7	2.4	3.8	-1.6	-0.7	-2.0
Current tobacco smoking	0.4	0.6	0.8	-0.8	-0.5	-0.9
Average weekly fortified wine intake	2.5	2.9	8.4	0.5	-0.0	2.9
Maternal smoking around birth	0.6	0.9	2.0	0.9	1.4	-0.2
Fed-up feelings	1.0	1.9	4.3	0.9	-2.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.0	-0.7	-0.7
Relative age voice broke	0.1	0.2	0.5	0.7	0.0	0.1
Taking other prescription medications	1.4	2.2	4.4	-1.4	0.5	-2.1
Age when periods started (menarche)	0.2	0.4	0.7	0.8	0.4	0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.9	0.1	1.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	8.9	-1.4	-1.5	-3.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	0.8	-0.8	-0.4
Qualifications: CSEs or equivalent	2.4	3.2	7.0	-1.5	0.5	-2.6
Serious illness, injury or assault to yourself	0.4	0.5	0.9	-0.6	0.5	-1.0
High blood pressure	2.3	6.4	10.2	-3.2	-0.5	-3.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.3	0.9	0.6	-1.5
Multivitamins +/- minerals	0.3	0.4	0.6	-0.6	0.8	-0.3
Stomach or abdominal pain in last month	0.3	0.4	0.4	-0.5	-0.7	-0.6
Supplements: Glucosamine	0.9	1.2	3.2	-1.8	-0.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.9	-0.5	-0.4	-1.4
Medication: Atenolol	1.8	2.3	5.0	-0.7	2.2	-1.1
Medication: Levothyroxine sodium	2.0	3.4	4.6	2.1	-1.0	2.1
Sitting height	2.2	15.8	19.8	-4.1	3.3	-4.5
Chronic bronchitis/emphysema (father)	1.0	1.2	2.8	-0.8	-0.5	-1.7
High blood pressure (mother)	2.7	3.8	5.9	-2.3	-0.3	-2.4
Body mass index (BMI)	2.7	11.4	28.6	-1.6	-1.8	-5.3
Impedance of leg (left)	5.2	25.1	66.1	2.6	1.5	8.1
Leg predicted mass (left)	6.0	31.6	72.8	-4.7	-0.1	-8.5
Trunk fat mass	3.6	15.3	33.2	-3.4	-0.9	-5.8
Waist circumference	4.9	18.0	42.5	-2.9	-1.7	-6.5
Number of incorrect matches in round	1.1	1.9	3.1	1.8	-0.4	1.5
Past tobacco smoking	0.2	0.3	0.6	0.4	0.8	0.4
Alcohol usually taken with meals	0.8	1.4	3.5	-0.6	1.9	0.4
Nervous feelings	0.9	1.7	2.5	0.6	-1.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.7	1.6	-0.8	-0.3
Hearing difficulty/problems with background noise	1.5	2.4	4.7	1.4	-0.7	2.2
Hair/balding pattern: Pattern 2	1.7	2.2	3.3	-1.8	0.4	-1.7
Had menopause	3.4	4.2	8.5	2.0	-0.4	2.9
Had other major operations	0.5	0.7	1.3	-0.5	-0.6	-1.2
Forced vital capacity (FVC)	0.0	0.1	0.2	0.0	-0.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.8	9.5	-2.0	-1.0	-3.1
Ever unenthusiastic/disinterested for a whole week	2.8	3.5	6.8	1.9	-2.6	0.4
Qualifications: None of the above	0.3	0.6	1.5	1.2	-0.6	-0.2
Financial difficulties in last 2 years	5.5	7.3	14.7	-1.4	-2.3	-3.8
Mouth/teeth dental problems	2.4	3.7	6.3	-0.5	2.5	-2.1
Heart attack	3.0	3.9	6.8	-1.7	1.4	-2.6
Allergy	1.9	4.3	10.6	1.4	-0.6	3.3
Pain all over the body in last month	0.3	0.4	1.0	0.3	0.2	1.0
Diabetes (self-reported)	7.7	11.8	20.9	-3.8	-0.4	-4.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	0.9	1.0	0.7	0.7
Medication: Ramipril	3.6	4.6	10.8	-1.7	-0.4	-3.3
Medication: Simvastatin	0.3	0.4	0.9	-0.0	-0.5	-0.9
Fluid intelligence score	0.4	0.9	1.5	-1.2	0.8	-0.7
Illnesses of siblings	2.1	2.9	7.5	1.1	0.2	2.7
Neuroticism score	1.9	3.9	8.9	1.3	-3.0	1.1
Weight	3.8	18.6	43.6	-3.5	-0.4	-6.6
Impedance of arm (right)	0.3	1.6	2.7	-1.6	1.1	0.9
Arm fat percentage (right)	3.3	12.9	29.2	-2.7	-1.5	-5.4
Trunk fat-free mass	2.2	12.7	26.3	-3.4	0.7	-5.1
Hip circumference	3.0	13.0	32.6	-2.4	-0.7	-5.7
Time employed in main current job	2.1	2.4	3.9	1.7	0.7	2.0
Alcohol intake versus 10 years previously	6.5	9.7	21.7	-2.5	1.1	-4.7
Father’s age at death	1.3	1.7	3.5	1.1	-0.7	1.9
Worrier / anxious feelings	1.7	3.2	3.6	1.9	-1.8	1.7
Frequency of tiredness / lethargy in last 2 weeks	4.4	7.2	16.5	-2.2	0.3	-4.1
Falls in the last year	1.2	1.7	2.1	-1.4	1.4	-1.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.5	0.1	0.4
Number of live births	0.2	0.2	0.7	-0.1	-0.8	0.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.0	1.5	0.3	2.4
Pulse rate	4.1	7.0	7.6	-2.4	-2.7	-2.8
Happiness	1.2	1.5	3.5	1.9	-0.5	0.8
Noisy workplace	1.4	1.7	2.5	-1.2	-1.1	-1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.3	0.8	0.2	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.4	0.5	-1.5	-0.2
Mouth/teeth dental problems: Dentures	1.7	2.9	7.7	0.5	-0.8	2.8
Asthma	1.6	3.2	6.1	-1.8	-0.2	-2.5
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.1	-2.0	1.1	-0.3
Medication: Cholesterol lowering	0.4	0.6	1.2	-1.1	0.7	-0.0
Depression (self-reported)	1.8	2.2	5.3	-0.9	-0.6	-2.3
Medication: Lansoprazole	0.5	0.5	1.3	0.4	-1.1	-0.3
Prospective memory result	0.1	0.2	0.3	0.4	0.5	0.3
Lung cancer (father)	0.4	0.5	0.7	0.2	-0.8	-0.8
Illnesses of mother	2.7	3.4	6.8	0.7	1.7	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	6.4	1.4	1.5	2.5
Pulse wave Arterial Stiffness index	1.1	1.3	2.1	-1.5	0.8	-1.1
Impedance of arm (left)	0.4	1.7	2.7	-1.6	1.1	1.0
Arm fat mass (right)	3.8	15.6	35.8	-3.0	-1.4	-6.0
Trunk predicted mass	2.1	12.0	24.6	-3.3	0.8	-5.0
Standing height	1.4	13.8	22.6	-4.8	2.8	-3.3
Length of working week for main job	0.4	0.5	0.7	-0.6	-0.5	-0.8
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.0	-0.2	0.7
Breastfed as a baby	0.9	1.2	3.1	0.5	-0.4	1.8
Tense / ‘highly strung’	1.0	1.7	2.8	-0.5	1.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	5.7	-0.8	0.5	-2.4
Hair/balding pattern: Pattern 4	2.4	5.9	9.8	2.8	0.4	3.1
Birth weight of first child	0.3	0.5	1.4	1.2	-0.1	0.3
Peak expiratory flow (PEF)	2.2	5.2	12.0	1.9	-0.0	3.5
Pulse wave reflection index	1.1	1.4	4.0	-0.4	2.0	-0.1
Ever highly irritable/argumentative for 2 days	5.0	6.0	9.2	3.0	-2.7	1.2
Loud music exposure frequency	2.9	3.2	7.8	-1.1	-0.8	-2.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	-0.3	0.5	0.9
Mouth/teeth dental problems: Bleeding gums	3.7	4.8	12.3	-0.5	-3.5	-1.4
Blood clot in the leg (DVT)	0.4	0.5	0.8	-0.7	0.9	-0.7
Medication: Paracetamol	0.7	1.1	2.6	-0.6	0.7	-1.6
Headache pain in last month	6.8	11.7	17.5	-4.2	0.8	-4.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.5	1.9	-0.6	1.3
Glaucoma (self-reported)	1.3	1.5	3.3	-0.8	0.8	-1.8
Gout (self-reported)	0.3	0.4	1.0	1.0	-0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.5	1.5	-0.5	1.6
Medication: Amlodipine	1.6	2.2	4.8	-1.3	-0.1	2.2
Medication: Ventolin 100micrograms inhaler	1.9	2.4	6.7	-0.4	-0.6	-2.6
Birth weight	1.9	4.2	6.0	2.4	1.0	2.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	0.2	0.1	-1.2
High blood pressure (siblings)	2.5	3.5	6.4	-2.0	-0.7	-2.5
Forced vital capacity (FVC), Best measure	0.1	0.5	1.3	-0.3	1.1	0.0
Body fat percentage	1.7	6.9	15.1	-2.1	-1.1	-3.9
Leg fat percentage (right)	0.4	1.3	2.4	-0.6	-1.1	-1.5
Arm fat-free mass (right)	1.4	7.1	16.5	-2.2	0.2	-4.1
Exposure to tobacco smoke outside home	1.9	2.5	6.6	-0.9	-0.3	-2.6
Comparative body size at age 10	0.4	1.0	2.3	-0.4	1.5	-0.8
Number of full brothers	2.9	3.7	7.2	-1.9	-0.5	-2.7
Worry too long after embarrassment	1.4	2.4	5.0	0.2	-2.2	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.2	-0.3	-0.4
Wheeze or whistling in the chest in last year	2.6	4.7	12.1	-1.2	-0.7	-3.5
Number of children fathered	3.0	3.3	7.1	-1.6	2.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.6	-0.2	-0.8	0.8
Age at first live birth	0.8	1.4	3.6	0.7	-0.3	1.9
Pulse wave peak to peak time	0.5	0.6	1.0	1.0	-0.3	0.8
Health satisfaction	0.8	1.0	2.2	-0.5	0.9	-1.5
Shortness of breath walking on level ground	1.0	1.2	2.7	0.0	-1.0	-1.6
Qualifications: College or University degree	0.2	0.8	1.6	0.6	0.5	1.3
Eye problems/disorders: None of the above	0.4	0.5	1.3	0.4	-1.1	0.0
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.6	0.5	-1.6	1.1
Emphysema/chronic bronchitis	0.9	1.1	2.8	-0.6	0.1	-1.7
Medication for pain relief, constipation, heartburn	1.6	2.7	4.3	1.5	-1.2	2.1
Neck or shoulder pain in last month	5.3	7.6	19.1	-1.9	0.0	-4.4
Medication: Blood pressure	2.0	3.5	5.6	-2.4	-0.1	-2.2
Angina (self-reported)	0.6	0.7	1.6	0.0	1.3	-0.8
Migraine (self-reported)	0.5	0.6	1.6	-0.4	-0.4	-1.3
Medication: Ibuprofen	0.7	0.8	2.3	-1.5	0.3	-0.1
Medication: Allopurinol	0.6	0.8	1.4	1.2	-1.0	-0.2
Medication: Omeprazole	2.3	2.7	5.4	-1.3	1.1	-2.3
Medication: Seretide 50 evohaler	1.5	1.7	3.7	-1.2	1.9	0.4
Mean time to correctly identify matches	1.4	2.7	4.2	1.9	0.3	2.1
Heart disease (mother)	1.1	1.3	3.6	-0.3	0.4	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	5.5	0.7	-2.3	0.5
Whole body fat mass	2.9	12.2	27.4	-2.9	-1.0	-5.2
Leg fat mass (right)	1.9	7.3	17.1	-1.9	-1.0	-4.1
Arm predicted mass (right)	1.6	8.4	18.7	-2.5	0.6	-4.3
Pulse rate, automated reading	5.8	18.9	36.2	-4.2	-1.7	-6.0
Alcohol intake frequency.	2.8	6.6	17.0	-1.6	0.1	-4.1
Comparative height size at age 10	1.1	5.9	8.2	-2.9	1.2	-2.9
Number of full sisters	1.8	2.2	5.0	0.4	-2.2	-1.2
Suffer from ‘nerves’	0.5	0.7	2.1	0.1	-1.4	0.3
Overall health rating	3.6	7.7	19.5	-1.8	-0.6	-4.4
Chest pain or discomfort	2.0	2.9	7.5	-0.9	-0.7	-2.7
Had major operations	0.2	0.3	0.7	-0.9	0.1	0.1
Age at last live birth	0.3	0.4	0.8	-0.3	0.6	0.9
Family relationship satisfaction	0.2	0.3	0.4	0.4	0.7	-0.4
Leg pain on walking	0.5	0.6	1.0	0.2	-1.0	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	-0.6	0.6	-1.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.7	0.5	0.4
Illness, injury, bereavement, stress in last 2 years	4.3	5.2	11.4	0.7	1.9	3.4
Medication: Aspirin	0.7	0.9	1.6	-1.2	0.0	-1.1
Supplements: Vitamin C	1.3	1.6	2.2	1.5	-0.8	1.4
Knee pain experienced in last month	4.5	7.1	16.9	-1.8	-1.0	-4.1
Hypertension (Self-reported)	2.0	5.5	8.8	-2.7	-0.4	-3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.3	0.1	-1.8	-0.5
Illnesses of father: Heart disease	0.5	0.7	1.3	1.1	-0.8	-0.2
Illnesses of siblings: Diabetes	1.3	1.6	3.3	0.3	1.2	-1.8
Smoking status: Previous	0.2	0.3	0.5	0.6	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.9	8.2	-2.4	2.9	-1.9
Whole body fat-free mass	3.3	18.9	41.9	-3.8	0.3	-6.5
Leg fat-free mass (right)	5.9	31.7	73.4	-4.6	-0.3	-8.6
Arm fat percentage (left)	3.0	11.9	26.8	-2.6	-1.5	-5.2
Average weekly red wine intake	0.7	1.1	3.2	0.1	0.1	1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-0.7	1.0	-0.7
Mood swings	0.4	0.7	2.2	0.3	-1.5	0.0
Loneliness, isolation	0.4	0.6	1.2	0.3	-1.1	-0.7
Long-standing illness, disability or infirmity	4.3	6.6	16.2	-1.8	0.6	-4.0
Ever had bowel cancer screening	0.6	0.7	2.1	0.2	-0.2	1.5
Diabetes diagnosed by doctor	8.5	13.9	26.2	-3.9	-0.4	-5.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.8	0.7	1.7	-0.3
Friendships satisfaction	0.7	0.9	1.2	1.1	0.9	0.7
Qualifications: nursing, teaching	1.1	1.7	4.4	-0.4	0.7	2.1
Commuting to job workplace: Walk	0.9	0.9	1.6	1.3	0.9	0.7
Eye problems/disorders: Cataract	1.1	1.3	2.0	1.4	0.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	0.8	-0.0	1.6
Medication for cholesterol	1.7	2.6	4.8	1.4	-1.0	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.6	1.7	-1.3	0.4	-0.3
Back pain experienced in last month	3.5	5.1	11.2	-1.6	-1.3	-3.3
Mineral and other dietary supplements	1.2	1.6	3.3	1.8	0.7	1.0
Breast cancer (self-reported)	0.9	1.1	2.9	-0.2	-1.7	-0.6
Asthma (self-reported)	1.8	3.6	7.2	-1.9	-0.0	-2.7
Osteoporosis (self-reported)	1.7	2.1	4.4	1.1	-0.9	2.1
Osteoarthritis (self-reported)	1.5	2.0	4.7	0.1	-2.2	-1.1
Medication: Aspirin	1.1	1.4	2.6	-1.6	0.0	-1.3
Medication: Gliclazide	1.5	1.7	3.2	-1.8	-0.1	-1.4
Illnesses of father: None of the above (group 1)	0.2	0.3	0.7	0.1	0.2	0.8
Smoking status: Current	0.3	0.4	0.8	-0.7	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.6	12.0	3.5	-0.3	3.3
Whole body water mass	3.2	18.0	39.7	-3.8	0.4	-6.3
Leg predicted mass (right)	5.8	31.0	71.7	-4.6	-0.4	-8.5
Arm fat mass (left)	3.4	13.9	32.2	-2.8	-1.3	-5.7
Number of self-reported non-cancer illnesses	2.7	4.6	10.3	-1.7	-0.9	-3.2
Average weekly champagne plus white wine intake	2.0	2.7	5.2	-2.3	1.6	-0.6
Miserableness	0.8	1.5	4.3	-0.2	-2.1	0.2
Guilty feelings	1.3	1.9	4.4	0.9	-2.1	0.7
Wears glasses or contact lenses	0.5	0.5	1.3	-1.1	-0.0	0.6
Ever taken oral contraceptive pill	3.4	3.7	7.1	-2.0	-0.5	-2.7
Hearing aid user	1.2	1.3	2.0	1.4	1.0	1.0
Mother’s age at death	7.0	8.8	9.5	3.0	-2.8	3.1
Financial situation satisfaction	1.6	2.0	3.3	-0.7	-1.5	-1.8
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.2	-1.8	0.3	-1.2
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.0	0.8	-0.7
Eye problems/disorders: Glaucoma	1.1	1.2	3.6	-0.3	-0.0	-1.9
Medication: Blood pressure	2.2	4.3	9.4	-1.8	-0.3	-3.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.9	-1.1	0.5	-2.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.0	-1.0	-0.9	0.0
High cholesterol (Self-reported)	0.6	1.1	2.4	-1.6	0.3	-0.9
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.0	0.5	-0.7
Medication: Paracetamol	1.6	2.4	3.4	-1.5	1.3	-1.9
Medication: Lisinopril	1.4	1.8	3.1	-1.8	0.6	-1.4
Medication: Atorvastatin	0.9	1.1	2.7	-1.6	-0.5	-0.5
Illnesses of father: High blood pressure	1.4	1.7	3.5	-1.1	0.7	-1.9
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	0.5	0.0
Ever smoked	0.5	0.9	1.9	-1.4	-0.9	-0.5
Basal metabolic rate	3.7	20.2	45.3	-3.9	0.0	-6.7
Leg fat percentage (left)	0.4	1.4	2.1	-0.3	-1.4	-1.5
Arm fat-free mass (left)	1.5	7.8	17.4	-2.4	0.4	-4.2
Number of operations (self-reported)	1.5	2.2	4.4	-1.4	-0.6	-2.1
Average weekly beer plus cider intake	1.1	1.6	2.3	-1.5	-0.1	-1.5
Irritability	1.3	2.2	3.8	1.0	-1.3	2.0
Risk taking	0.6	0.9	1.9	-1.4	0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.6	1.0	0.3
Fractured/broken bones in last 5 years	1.4	1.8	3.1	-1.8	1.1	1.0
Age started oral contraceptive pill	2.4	3.1	5.7	1.9	0.2	2.4
Diastolic blood pressure, automated reading	2.0	6.2	14.1	-2.0	-0.7	-3.8
Ever depressed for a whole week	3.7	4.6	13.5	-0.3	-3.7	-0.4
Unable to work because of sickness or disability	0.3	0.4	0.6	-0.8	-0.4	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.4	-0.4	0.1
Myopia	0.1	0.1	0.3	0.2	-0.3	0.6
Vascular/heart problems diagnosed by doctor	2.3	6.2	9.4	3.1	0.2	3.0
Cholesterol lowering medication	0.9	1.3	2.5	-0.9	-0.7	-1.6
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	6.6	-1.6	0.1	-2.6
Pain experienced in last month	7.8	13.0	29.3	3.0	0.8	5.4
Supplements: Calcium	0.9	0.9	1.4	0.9	0.8	1.2
Basal cell carcinoma (self-reported)	1.5	1.8	4.5	-0.2	-2.1	0.9
Heart attack/myocardial infarction (self-reported)	3.1	4.1	6.7	-1.8	1.5	-2.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.0	-1.0	0.8	-0.9
Heart disease (siblings)	0.1	0.1	0.2	0.2	-0.1	-0.5
Alcohol drinker status: Previous	0.9	1.0	1.6	0.5	-1.3	-1.1
Pack years of smoking	0.1	0.2	0.3	-0.6	0.2	-0.5
Impedance of whole body	1.4	7.3	19.9	0.3	1.4	4.5
Leg fat mass (left)	1.9	7.4	17.6	-1.8	-1.1	-4.2
Arm predicted mass (left)	1.7	8.6	19.6	-2.5	0.3	-4.4