[Hub]/) : Traits : HDL Cholesterol : ← →

chr12:123,040,985-125,270,773

Best TWAS P=7.74e-16 · Best GWAS P=2.58e-14 conditioned to 3.06e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-4.5	7.2	5.7e-13	0.00	0.08	0.92	FALSE
2	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	6.2	8.0	9.9e-16	0.05	0.02	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	6.2	8.0	1.4e-15	0.06	0.02	0.97	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	4.9	8.1	7.7e-16	0.06	0.03	0.82	TRUE
5	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	6.2	6.2	7.7e-10	0.04	0.02	0.98	FALSE
6	GTEx	Breast Mammary Tissue (Female)	CCDC92	0.05	-0.01	enet	2	-0.01	6.2e-01	5.6	5.6	1.9e-08	0.06	0.04	0.30	FALSE
7	GTEx	Cells Transformed fibroblasts	SBNO1	0.09	0.03	lasso	6	0.03	1.2e-03	4.8	5.3	1.2e-07	0.01	0.01	0.97	FALSE
8	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	6.2	6.5	7.8e-11	0.04	0.02	0.94	FALSE
9	GTEx	Esophagus Mucosa	CCDC92	0.11	0.02	lasso	4	0.02	1.9e-02	5.8	5.7	9.6e-09	0.06	0.07	0.84	FALSE
10	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	6.2	6.2	5.4e-10	0.05	0.02	0.98	FALSE
11	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	4.5	5.6	2.3e-08	0.06	0.05	0.94	FALSE
12	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	6.2	6.6	4.8e-11	0.04	0.02	0.98	FALSE
13	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	5.8	6.6	4.3e-11	0.05	0.05	0.95	FALSE
14	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	6.1	5.9	2.9e-09	0.01	0.06	0.68	FALSE
15	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	6.1	5.9	3.3e-09	0.05	0.02	0.98	FALSE
16	GTEx	Muscle Skeletal	RP11-380L11.4	0.14	0.03	lasso	8	0.03	4.0e-04	6.2	5.8	7.5e-09	0.04	0.02	0.98	FALSE
17	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	4.8	5.2	2.0e-07	0.04	0.07	0.63	FALSE
18	GTEx	Skin Sun Exposed Lower leg	RP11-380L11.4	0.04	0.02	enet	15	0.02	1.9e-02	6.1	5.6	1.8e-08	0.04	0.03	0.94	FALSE
19	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	6.3	6.4	1.2e-10	0.03	0.02	0.96	FALSE
20	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	5.6	-6.4	1.6e-10	-0.06	0.03	0.97	FALSE
21	GTEx	Whole Blood	CDK2AP1	0.24	0.18	lasso	5	0.18	1.1e-16	4.8	5.2	2.2e-07	0.02	0.01	0.99	FALSE
22	GTEx	Whole Blood	RP11-282O18.3	0.20	0.15	lasso	4	0.15	1.7e-13	4.8	5.2	1.8e-07	0.02	0.01	0.99	FALSE
23	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	-4.3	7.8	9.2e-15	0.06	0.10	0.90	FALSE
24	METSIM	Adipose	DNAH10	0.03	0.00	bslmm	475	0.01	3.2e-03	5.9	6.7	1.6e-11	0.04	0.04	0.81	FALSE
25	METSIM	Adipose	RP11-214K3.24	0.05	0.03	bslmm	444	0.02	2.7e-04	5.8	6.8	1.0e-11	0.09	0.03	0.95	FALSE
26	NTR	Blood	CDK2AP1	0.06	0.04	blup	334	0.04	2.4e-14	4.9	5.8	6.4e-09	0.03	0.01	0.99	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAH10	0.11	0.03	blup	99	0.05	8.2e-11	4.6	6.6	4.6e-11	0.10	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC92	0.07	0.02	blup	52	0.04	1.8e-02	5.6	5.8	8.4e-09	0.05	0.02	0.71	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	6.2	6.0	1.7e-09	0.07	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCDC92	0.05	0.03	blup	52	0.03	5.8e-03	3.4	5.2	1.6e-07	0.04	0.03	0.75	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	DNAH10	0.04	0.03	lasso	5	0.02	4.6e-03	4.8	5.7	1.2e-08	0.06	0.02	0.80	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	6.2	-5.7	1.3e-08	-0.04	0.02	0.98	FALSE