[Hub]/) : Traits : HDL Cholesterol : ← →

chr12:108,763,672-110,729,807

Best TWAS P=1.81e-15 · Best GWAS P=6.88e-15 conditioned to 0.218

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MMAB	0.12	0.09	enet	13	0.08	2.9e-10	7.2	-7.3	3.0e-13	0.76	0.16	0.84	FALSE
2	GTEx	Adipose Subcutaneous	KCTD10	0.17	0.09	enet	13	0.15	1.8e-12	5.4	-6.3	3.0e-10	0.76	0.17	0.83	FALSE
3	GTEx	Adipose Visceral Omentum	MMAB	0.10	-0.01	lasso	4	0.00	3.8e-01	-7.5	-7.5	7.5e-14	0.96	0.02	0.84	FALSE
4	GTEx	Artery Aorta	KCTD10	0.18	0.05	enet	9	0.10	4.4e-06	5.4	-5.6	2.0e-08	0.72	0.03	0.96	FALSE
5	GTEx	Brain Cerebellar Hemisphere	MMAB	0.31	0.27	lasso	3	0.24	6.6e-07	5.4	-5.5	4.5e-08	0.58	0.48	0.43	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	MMAB	0.40	0.24	enet	16	0.28	2.5e-08	5.3	-6.5	7.1e-11	0.74	0.05	0.86	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	KCTD10	0.36	0.18	lasso	7	0.19	1.0e-06	5.4	-6.5	8.3e-11	0.74	0.16	0.81	FALSE
8	GTEx	Cells Transformed fibroblasts	KCTD10	0.37	0.31	enet	25	0.37	6.5e-29	5.4	-6.5	6.2e-11	0.88	0.07	0.93	FALSE
9	GTEx	Cells Transformed fibroblasts	MMAB	0.07	0.06	enet	9	0.05	7.3e-05	6.9	-6.3	2.5e-10	0.61	0.42	0.49	FALSE
10	GTEx	Colon Sigmoid	KCTD10	0.25	0.16	lasso	8	0.15	6.2e-06	7.3	-7.7	2.0e-14	0.95	0.01	0.98	FALSE
11	GTEx	Colon Transverse	KCTD10	0.22	0.12	lasso	11	0.13	1.1e-06	-7.7	-8.0	1.8e-15	0.92	0.01	0.99	TRUE
12	GTEx	Colon Transverse	MMAB	0.08	0.07	lasso	2	0.05	1.7e-03	7.3	-7.6	3.0e-14	0.93	0.02	0.96	FALSE
13	GTEx	Colon Transverse	UBE3B	0.19	0.14	lasso	5	0.10	1.5e-05	6.6	-5.7	1.1e-08	0.70	0.60	0.33	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	KCTD10	0.15	0.00	enet	17	0.02	6.0e-02	3.5	-5.6	2.1e-08	0.59	0.05	0.50	FALSE
15	GTEx	Esophagus Mucosa	KCTD10	0.22	0.17	enet	35	0.24	6.8e-16	-7.6	-6.3	3.3e-10	0.87	0.01	0.99	FALSE
16	GTEx	Esophagus Muscularis	KCTD10	0.21	0.19	lasso	6	0.17	1.3e-10	5.3	-6.3	2.7e-10	0.84	0.08	0.92	FALSE
17	GTEx	Nerve Tibial	KCTD10	0.18	0.13	lasso	3	0.15	7.4e-11	3.5	-5.3	1.3e-07	0.63	0.89	0.11	FALSE
18	GTEx	Nerve Tibial	USP30	0.07	0.01	lasso	4	0.01	1.1e-01	6.9	7.0	3.5e-12	-0.75	0.05	0.73	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	UNG	0.14	0.16	lasso	3	0.15	1.9e-08	6.0	-6.3	3.6e-10	0.64	0.95	0.05	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	KCTD10	0.24	0.18	lasso	5	0.18	3.0e-10	5.4	-5.7	9.0e-09	0.71	0.95	0.05	FALSE
21	GTEx	Skin Sun Exposed Lower leg	UNG	0.29	0.19	enet	32	0.20	1.8e-16	6.1	-5.2	2.1e-07	0.54	1.00	0.00	FALSE
22	GTEx	Testis	KCTD10	0.24	0.12	enet	25	0.23	1.4e-10	-7.6	-6.4	1.9e-10	0.76	0.01	0.99	FALSE
23	GTEx	Thyroid	KCTD10	0.06	0.02	enet	12	0.02	9.2e-03	5.9	-6.1	8.3e-10	0.75	0.03	0.94	FALSE
24	GTEx	Thyroid	MMAB	0.07	0.00	lasso	6	0.02	5.4e-03	-7.5	-6.7	1.7e-11	0.72	0.02	0.95	FALSE
25	GTEx	Whole Blood	MVK	0.05	0.00	enet	13	0.00	4.8e-01	-7.2	-6.0	1.8e-09	0.81	0.04	0.74	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KCTD10	0.06	0.00	lasso	3	0.00	1.4e-01	5.4	-6.0	1.8e-09	0.64	0.01	0.53	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	MMAB	0.03	0.01	blup	57	0.02	6.5e-06	7.3	-5.5	4.4e-08	0.74	0.02	0.95	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYO1H	0.08	0.12	enet	14	0.10	1.7e-19	6.6	6.9	6.2e-12	-0.83	0.74	0.26	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	KCTD10	0.27	0.20	lasso	1	0.18	4.5e-06	5.4	-5.4	5.1e-08	0.56	0.16	0.54	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MMAB	0.03	0.02	blup	57	0.02	2.2e-03	6.9	-7.1	1.7e-12	0.87	0.01	0.91	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MMAB	0.04	0.02	blup	53	0.02	5.2e-03	7.3	-6.6	3.0e-11	0.74	0.02	0.42	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYO1H	0.22	0.16	lasso	5	0.15	4.1e-16	-6.6	6.7	1.8e-11	-0.79	0.79	0.21	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MMAB	0.09	0.05	blup	57	0.09	6.3e-06	7.3	-6.3	2.2e-10	0.83	0.01	0.97	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MVK	0.06	0.02	enet	5	0.06	2.1e-04	7.3	-6.7	1.6e-11	0.76	0.01	0.78	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYO1H	0.05	0.02	blup	87	0.04	2.1e-03	-6.8	6.8	8.6e-12	-0.71	0.07	0.48	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	MYO1H	0.13	0.15	lasso	5	0.16	2.2e-18	6.6	7.1	9.9e-13	-0.82	0.52	0.48	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MMAB	0.07	0.00	blup	57	0.02	6.6e-03	4.8	-5.2	2.5e-07	0.47	0.05	0.14	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYO1H	0.08	0.04	lasso	3	0.04	3.7e-05	-7.1	7.2	4.9e-13	-0.92	0.01	0.98	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	KCTD10	0.12	0.00	blup	61	0.03	2.2e-02	5.5	-6.4	1.8e-10	0.69	0.01	0.41	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYO1H	0.19	0.09	enet	9	0.11	3.4e-05	-6.6	7.7	1.9e-14	-0.88	0.01	0.98	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD10	0.30	0.20	enet	12	0.22	3.1e-22	-6.6	-7.2	6.6e-13	0.86	0.19	0.81	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-7.7	-7.7	1.8e-14	0.93	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYO1H	0.09	0.12	lasso	5	0.12	5.2e-12	-6.6	-7.2	7.4e-13	0.81	0.68	0.32	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBE3B	0.20	0.02	lasso	2	0.02	9.1e-03	-6.6	-6.7	1.8e-11	0.84	0.04	0.41	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	MYO1H	0.06	0.09	lasso	3	0.09	5.4e-06	-6.6	7.0	2.2e-12	-0.76	0.05	0.93	FALSE
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYO1H	0.08	0.06	blup	83	0.06	3.0e-05	-7.1	7.3	2.3e-13	-0.89	0.00	0.99	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	KCTD10	0.15	0.08	lasso	6	0.08	2.1e-08	4.4	-6.0	2.1e-09	0.66	0.77	0.23	FALSE