Best TWAS P=2.98e-13 · Best GWAS P=1.08e-15 conditioned to 0.000873
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | MAN2A1 | 0.07 | 0.01 | lasso | 2 | 0.01 | 0.03660 | -1.5 | 5.2 | 2.0e-07 | -0.71 | 0.09 | 0.66 | FALSE |
| 2 | GTEx | Whole Blood | PJA2 | 0.05 | 0.00 | enet | 17 | 0.00 | 0.12200 | -7.9 | -6.2 | 5.0e-10 | 0.73 | 0.02 | 0.91 | FALSE |
| 3 | NTR | Blood | PJA2 | 0.04 | 0.02 | lasso | 1 | 0.01 | 0.00016 | -6.5 | -6.5 | 8.3e-11 | 0.82 | 0.38 | 0.56 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PJA2 | 0.02 | 0.01 | blup | 59 | 0.02 | 0.00032 | -7.5 | -7.3 | 3.0e-13 | 0.92 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PJA2 | 0.03 | 0.04 | lasso | 1 | 0.03 | 0.00042 | 6.4 | 6.4 | 1.3e-10 | -0.78 | 0.14 | 0.66 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PJA2 | 0.02 | 0.00 | blup | 58 | 0.01 | 0.04330 | -4.2 | -6.7 | 2.8e-11 | 0.89 | 0.03 | 0.38 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | PJA2 | 0.02 | 0.00 | blup | 59 | 0.00 | 0.16500 | -8.0 | -7.2 | 6.0e-13 | 0.79 | 0.01 | 0.62 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PJA2 | 0.02 | 0.00 | blup | 58 | 0.00 | 0.18800 | -3.9 | -5.7 | 1.5e-08 | 0.83 | 0.03 | 0.50 | FALSE |