Hub : Genes

PJA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0885 0.0370 1.4e-03 0.021 NA -0.001 NA 0.008 1.1e-02 NA 0.36000 NA 0.08800
2 GTEx Whole Blood 0.0500 0.0260 5.6e-03 -0.001 NA 0.004 NA 0.000 4.0e-01 NA 0.12000 NA 0.36000
3 METSIM Adipose 0.0395 0.0197 3.7e-03 0.000 0.006 0.000 0.006 0.001 3.0e-01 3.9e-02 0.33000 0.03700 0.18000
4 NTR Blood 0.0393 0.0159 8.8e-05 0.018 0.009 0.008 0.009 0.011 1.4e-06 5.0e-04 0.00096 0.00034 0.00016
5 ROSMAP Brain Pre-frontal Cortex 0.0767 0.0321 4.5e-04 0.000 0.022 0.023 0.023 0.010 2.9e-01 5.9e-04 0.00051 0.00055 0.01500
6 TCGA Breast Invasive Carcinoma 0.0167 0.0085 4.3e-05 0.010 0.015 0.008 NA 0.009 2.8e-03 3.2e-04 0.00650 NA 0.00470
7 TCGA Head and Neck Squamous Cell Carcinoma 0.0255 0.0165 3.1e-03 0.037 0.015 0.022 NA 0.027 4.9e-05 7.9e-03 0.00130 NA 0.00042
8 TCGA Kidney Renal Clear Cell Carcinoma 0.0448 0.0237 2.6e-04 0.024 0.035 0.018 NA 0.022 8.7e-04 6.7e-05 0.00370 NA 0.00130
9 TCGA Brain Lower Grade Glioma 0.0199 0.0138 9.6e-03 0.001 0.007 0.001 NA 0.001 2.6e-01 4.3e-02 0.26000 NA 0.24000
10 TCGA Lung Adenocarcinoma 0.0239 0.0153 7.8e-03 -0.002 0.002 -0.001 NA -0.002 7.3e-01 1.6e-01 0.52000 NA 0.72000
11 TCGA Prostate Adenocarcinoma 0.0235 0.0154 8.2e-03 0.001 0.002 -0.002 NA -0.002 2.3e-01 1.9e-01 0.81000 NA 0.66000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.1 0.2 0.5 0.0 0.7 0.4 0.1 -0.6 0.3 -0.4 0.0 0.4 0.5 0.3
Bipolar Disorder or Schizophrenia 2.0 4.8 13.3 0.7 3.6 1.9 2.2 -2.4 2.0 -2.1 1.0 2.1 2.8 1.7
Depressed Affect (Nagel 2018) 0.7 1.4 2.4 -0.6 -1.0 0.0 -1.4 1.5 -0.8 1.4 -1.6 -1.4 -1.1 -1.4
Depression (Nagel 2018) 0.3 0.4 0.7 -0.5 0.8 0.8 0.3 0.9 0.7 0.8 0.6 0.2 -0.5 0.5
Intelligence (Savage-Jansen 2018) 1.3 3.9 7.3 0.6 2.7 0.8 2.2 -2.0 1.7 -2.3 2.2 2.3 1.3 2.3
Neuroticism (Nagel 2018) 0.2 0.6 1.6 0.3 -0.7 0.4 -1.3 1.2 -0.3 0.5 -0.9 -0.6 -0.8 -0.5
Schizophrenia (2018) 2.9 6.0 14.4 0.9 3.8 2.1 2.7 -2.6 2.3 -2.4 1.4 2.3 3.2 2.0
Schizophrenia vs Biploar Disorder 0.4 0.5 2.4 -1.0 1.6 0.4 1.0 -0.1 0.7 -0.2 0.5 0.4 0.4 0.2
Worry (Nagel 2018) 0.3 0.7 1.8 0.9 0.4 1.3 -0.4 0.0 1.0 -1.3 0.1 1.2 0.6 0.8
Alzheimer’s Disease (in mother) 0.1 0.2 0.4 0.5 -0.2 0.5 -0.2 0.1 -0.6 -0.3 -0.6 0.0 -0.5 -0.1
Alzheimer’s Disease (in father) 0.2 0.3 0.9 0.6 -0.2 0.4 0.3 0.7 0.8 0.1 0.2 0.2 1.0 0.1
Alzheimer’s Disease (including proxy) 0.2 0.3 0.9 0.6 -0.7 0.5 -0.7 0.3 -0.4 0.3 -0.9 -0.3 -0.1 -0.4
Crohns Disease (2017) 0.5 1.0 4.5 -1.0 -2.1 -0.2 -0.1 0.9 -1.0 0.1 -0.2 -0.5 -1.8 -0.6
Irritable Bowel Disease (IBD) 1.7 4.1 9.0 -2.4 -3.0 -2.0 -1.5 -0.3 -2.5 1.3 -1.2 -1.9 -2.8 -1.9
Ulcerative Colitis (UC) 2.3 4.4 7.3 -2.4 -2.2 -2.4 -2.0 -1.0 -2.7 1.4 -1.7 -2.2 -2.2 -2.2
Major Depression (MDD) 1.1 1.4 3.0 1.7 -0.5 1.7 0.6 0.8 1.2 -0.7 1.5 1.1 -0.6 1.4
Reaction Time 7.1 13.5 20.3 4.1 3.9 4.2 3.8 0.4 3.9 -3.1 4.2 4.2 1.8 4.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.6 -0.5 1.4 -0.1 0.7 -1.6 0.8 -1.1 1.0 1.1 0.7 1.3
Breast Cancer 0.6 1.3 2.7 1.4 1.6 -0.0 0.9 -0.8 1.2 -1.5 1.5 1.0 0.3 1.2
Ovarian Cancer 0.9 1.2 4.6 -0.1 2.2 0.8 1.0 -0.0 1.0 -1.4 1.0 0.8 1.0 0.8
Prostate Cancer 0.3 0.4 0.7 0.8 -0.1 -0.6 0.5 0.5 0.8 -0.1 0.9 0.6 0.1 0.9
Age at First Birth 1.7 2.4 11.7 -1.7 2.3 0.2 0.5 -3.4 0.2 -0.7 -1.2 0.0 2.1 -0.6
Bipolar Disorder (2011) 0.6 0.5 1.4 -0.2 1.1 0.7 1.2 -0.1 0.6 -0.5 1.0 0.8 -0.2 0.8
Body Mass Index (BMI) (2010) 2.6 3.5 7.6 -2.1 -1.6 -2.3 -1.7 -0.3 -2.1 1.8 -0.9 -2.1 -2.8 -1.6
Coronary Artery Disease (CAD) 0.1 0.2 0.5 0.2 -0.3 -0.5 -0.3 -0.7 -0.2 0.2 0.7 -0.2 -0.1 0.4
Crohns Disease (2012) 0.6 1.0 4.6 -1.1 -1.7 -0.2 -0.1 0.4 -0.6 0.9 0.3 -0.4 -2.1 -0.3
Mean Putamen Volume 0.4 0.4 0.8 -0.1 0.5 0.6 0.9 -0.0 0.6 -0.8 0.6 0.7 0.7 0.9
Fasting Glucose 1.0 1.2 7.8 0.8 2.8 0.7 0.9 -0.5 0.6 -0.6 0.4 0.8 1.0 0.6
HbA1C 1.0 1.1 2.3 -1.0 -0.3 -1.5 -0.8 -0.4 -1.1 1.5 -0.3 -1.3 -1.2 -0.9
HDL Cholesterol 0.8 1.3 2.6 1.2 0.7 0.3 1.5 1.5 1.2 -1.0 0.8 1.6 0.7 1.1
LDL Cholesterol 1.4 2.1 4.7 -2.2 -0.3 -1.2 -2.1 -0.8 -1.9 1.0 -1.1 -1.8 -1.3 -1.3
Lupus 0.2 0.3 1.0 -0.3 0.5 0.6 -0.7 0.4 0.2 -1.0 -0.3 0.5 -0.0 0.3
Neuroticism (2016) 0.4 0.6 2.1 -0.6 -1.2 -0.2 -1.1 -0.6 -0.1 0.8 -0.5 -0.3 -1.5 -0.5
Primary Biliary Cirrhosis 0.2 0.3 1.0 0.1 -0.1 1.0 0.7 -0.1 0.0 0.8 0.8 -0.1 -0.4 0.3
Rheumatoid Arthritis 0.4 0.6 1.4 -0.5 -0.3 -0.1 -0.6 -0.3 -1.2 0.7 -1.1 -1.2 -0.2 -1.1
Schizophrenia (2014) 2.1 4.7 13.2 0.6 3.6 1.6 2.2 -2.4 1.9 -2.6 1.4 2.2 2.1 1.8
Triglycerides 0.3 0.5 1.4 -1.2 -0.7 -0.4 -1.0 -0.2 -0.8 0.3 -0.3 -0.6 -0.8 -0.3
Type 2 Diabetes (T2D) (2012) 1.7 1.9 6.2 1.0 1.6 0.6 1.1 -0.0 1.5 -2.5 0.9 1.8 1.2 1.4
Ulcerative Colitis 2.9 4.2 7.3 -2.7 -1.9 -2.1 -1.6 -0.4 -2.1 2.4 -1.2 -2.6 -2.2 -2.2
Blood Eosinophil Count 0.7 5.1 11.8 -1.2 -1.9 -2.0 -3.4 0.3 -2.9 1.6 -1.6 -2.9 -2.8 -2.3
Blood Platelet Count 0.3 3.6 14.4 -0.2 2.6 -0.1 1.7 -1.4 1.8 -2.6 0.3 1.9 3.8 0.8
Blood Red Count 0.8 7.5 10.2 -3.2 -1.8 -3.0 -3.2 -2.3 -2.7 3.1 -2.8 -3.0 -1.4 -3.1
Blood White Count 0.5 3.9 7.8 -1.2 -1.9 -2.6 -2.8 -0.7 -2.5 1.6 -1.3 -2.4 -1.4 -2.0
Heel T-Score 4.1 32.8 53.3 -3.2 -6.2 -4.9 -6.5 1.4 -7.3 6.4 -4.6 -6.7 -7.2 -5.7
BMI 2.6 15.2 23.8 -3.3 -3.4 -3.6 -4.6 -1.8 -4.8 3.9 -3.1 -4.5 -4.9 -4.0
Height 0.4 7.5 16.3 2.2 1.7 4.0 3.3 1.8 2.9 -3.2 2.0 3.3 2.0 2.7
Waist Hip Ratio (WHR) 0.7 3.2 9.7 1.5 0.3 2.4 1.4 -0.9 2.2 -0.7 3.1 1.7 1.0 2.3
Systolic Blood Pressure 0.0 0.2 0.7 -0.2 0.6 -0.1 0.0 0.1 0.2 -0.8 0.7 0.2 0.1 0.5
Smoking Status 1.3 3.1 7.5 -0.3 -2.4 -0.1 -1.8 2.7 -1.6 2.1 -1.0 -1.8 -2.0 -1.5
Allergy or Eczema 1.4 3.6 7.8 -1.4 -0.4 -1.7 -2.3 0.1 -2.2 2.8 -2.0 -2.2 -1.9 -2.2
Cardiovascular Disease 0.5 1.6 4.3 -0.6 -0.7 -0.6 -2.1 0.6 -1.4 1.8 -1.1 -1.5 -1.2 -1.3
Hypothyroidism (self reported) 1.4 3.3 6.9 -1.4 -1.9 -1.4 -2.1 2.6 -1.9 1.0 -2.0 -1.8 -1.1 -1.8
Respiratory disease 2.7 6.0 14.3 -1.3 -3.8 -2.3 -3.0 1.7 -2.7 1.5 -2.1 -2.3 -2.9 -2.3
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.3 -0.3 -1.0 0.0 -0.9 -0.8 -1.0 0.1 0.2 -0.6 -1.5 -0.0
Lung FEV1/FVC ratio 0.2 1.1 4.7 1.3 1.8 0.3 0.5 2.2 1.0 0.9 0.1 0.2 0.6 0.0
Lung FVC 0.1 0.8 5.0 0.4 -0.4 0.7 -0.6 2.2 -0.3 0.7 -0.7 -0.6 -0.7 -0.6
Neuroticism 0.4 0.9 3.1 1.8 0.4 1.0 -0.3 1.3 1.1 -0.6 0.5 0.8 -0.4 1.1
Chronotype (morning person) 2.3 5.3 8.9 -2.6 -1.9 -2.1 -1.1 1.8 -2.8 3.0 -1.5 -2.9 -2.3 -2.6
Hair Pigment 0.0 0.6 2.3 -0.2 -1.0 -0.3 -1.0 1.5 -0.8 -0.2 -0.3 -0.8 -0.9 -0.7
Tanning 0.1 1.1 5.7 -0.4 -0.0 -0.7 0.1 2.4 -0.9 1.3 0.1 -0.9 -1.6 -0.3
Hand grip strength (left) 0.2 0.6 2.7 -0.8 0.3 -1.3 -0.3 -0.0 -0.7 -1.6 -0.5 -0.2 0.3 -0.4
Number of treatments/medications taken 2.4 4.3 7.9 -1.6 -2.6 -1.3 -2.8 0.2 -2.6 2.4 -1.2 -2.5 -2.5 -1.7
Average weekly spirits intake 0.2 0.3 1.8 0.2 -1.3 0.3 -0.4 0.7 -0.1 -0.2 0.5 -0.3 -0.4 0.1
Sensitivity / hurt feelings 1.2 2.1 3.6 -0.4 -1.6 -1.9 -1.8 -0.5 -1.6 1.1 -1.6 -1.9 -0.9 -1.8
Frequency of depressed mood in last 2 weeks 0.7 1.0 4.5 -1.0 -0.7 0.3 -0.9 0.6 -0.4 2.1 -0.7 -1.3 -0.2 -1.1
Hearing difficulty/problems: Yes 0.5 0.8 2.5 1.6 0.4 1.1 0.1 0.6 0.5 0.8 1.0 0.5 -1.3 0.7
Relative age of first facial hair 1.8 3.8 9.4 0.9 1.8 2.5 3.1 0.9 2.0 -1.7 1.0 2.2 2.4 1.6
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 3.8 2.0 0.1 1.4 0.4 0.4 1.2 -0.6 0.4 1.2 0.5 0.8
Ever used hormone-replacement therapy (HRT) 3.5 4.4 15.1 -0.7 -3.9 -2.2 -2.7 1.2 -2.2 1.4 -1.1 -2.1 -2.3 -1.5
Ever had hysterectomy (womb removed) 3.8 4.3 6.1 -1.9 -2.1 -1.9 -2.2 -1.5 -2.5 2.3 -1.8 -2.5 -1.6 -2.3
Systolic blood pressure, automated reading 0.2 0.6 2.5 -0.7 -0.5 -1.6 -0.7 -1.1 -0.5 0.3 0.5 -0.6 -0.7 0.0
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 10.2 1.3 0.4 2.4 1.1 -0.1 2.0 -0.2 3.2 1.7 -1.8 2.5
Angina 1.5 1.9 3.7 -1.7 -1.9 -0.9 -1.4 -1.1 -1.0 1.7 -1.5 -1.5 -0.5 -1.4
Medication for hormone replacement therapy 2.0 2.3 5.1 -0.9 -2.0 -1.5 -2.2 0.3 -1.8 0.7 -1.3 -1.8 -1.2 -1.6
Vitamin and mineral supplements 0.5 0.6 2.8 -0.0 -0.1 0.8 0.9 1.7 0.4 0.5 1.2 0.3 -0.4 0.6
Supplements: Zinc 0.3 0.3 1.0 -0.8 -0.9 -1.0 -0.3 0.5 0.0 0.0 -0.4 -0.3 -0.8 -0.4
Medication: Co-codamol 0.5 0.5 1.8 -1.0 -0.6 -0.4 -0.9 0.1 -0.5 1.3 -0.5 -1.0 -0.1 -0.6
Medication: Metformin 0.3 0.5 3.7 -0.7 -0.5 -0.2 -0.3 -1.9 -0.3 -0.2 0.5 -0.2 -0.4 0.3
Diabetes (father) 0.3 0.4 1.4 -0.2 -0.5 -0.4 -1.2 -0.5 -0.6 -0.8 -0.8 -0.2 -0.5 -0.6
Diabetes (mother) 0.2 0.3 1.6 1.2 -0.2 -0.4 0.2 -0.6 -0.2 0.2 -0.5 0.2 -0.9 -0.1
Severe depression (siblings) 1.2 1.4 4.2 -1.4 0.8 -0.6 -1.1 -2.1 -0.2 -0.9 -1.7 -0.4 1.4 -0.9
Pack years adult smoking proportion 0.7 1.0 3.4 -0.2 0.3 0.1 0.8 -0.9 1.1 -1.4 1.9 1.0 0.2 1.4
Impedance of leg (right) 0.2 1.0 4.8 0.6 1.5 0.3 1.1 2.2 0.7 -0.2 0.2 0.4 1.3 0.4
Leg fat-free mass (left) 0.1 0.6 3.0 -0.1 -0.6 0.8 -0.4 -1.1 -0.2 -1.7 0.2 0.6 -0.6 0.4
Trunk fat percentage 1.0 3.9 9.1 -1.8 -3.0 -1.4 -2.5 -1.3 -2.2 1.7 -1.2 -2.2 -2.1 -1.7
Hand grip strength (right) 0.3 0.9 3.1 -1.4 0.8 -1.5 0.1 -1.1 -0.2 -1.8 -0.3 0.1 0.7 -0.3
Townsend deprivation index at recruitment 0.1 0.2 0.9 0.3 -0.4 0.4 -0.6 0.2 -0.2 0.9 0.3 -0.3 -0.5 -0.0
Current tobacco smoking 0.3 0.5 3.2 -0.4 -0.2 -0.2 0.2 1.8 0.0 0.9 0.9 -0.4 -0.8 0.2
Average weekly fortified wine intake 1.4 1.7 5.4 2.3 0.7 1.2 0.8 0.5 1.3 -0.9 1.1 1.3 1.7 1.4
Maternal smoking around birth 2.2 3.2 6.1 -1.9 -2.1 -1.5 -2.5 -1.1 -2.0 0.4 -2.3 -1.6 -1.2 -2.0
Fed-up feelings 1.1 2.0 5.8 -0.2 -2.4 -0.1 -2.4 0.8 -1.2 1.1 -1.3 -1.4 -1.5 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.1 -1.1 0.4 0.1 -0.3 1.0 0.4 0.7 -0.1 -0.2 -0.1 -0.2
Relative age voice broke 0.5 0.8 3.0 -0.4 1.2 -0.1 1.5 0.1 1.0 -0.1 -0.5 0.6 1.7 -0.0
Taking other prescription medications 1.3 2.0 4.7 -1.0 -1.9 -0.5 -2.2 0.3 -2.1 0.7 -0.6 -1.6 -1.9 -1.1
Age when periods started (menarche) 0.3 0.6 3.5 -0.1 0.1 1.9 -0.9 -0.1 -0.5 1.0 -0.2 -0.2 -1.2 -0.1
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 4.7 -0.8 -2.2 -0.3 -1.3 0.1 -0.9 0.9 -0.8 -0.9 -0.7 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 8.9 -0.2 -1.6 -0.4 -2.4 0.2 -1.9 1.5 -0.5 -1.3 -3.0 -0.7
Tinnitus: Yes, but not now, but have in the past 1.4 1.4 6.7 1.6 -0.7 2.6 -0.1 0.7 0.4 -0.4 1.6 0.6 -0.6 1.3
Qualifications: CSEs or equivalent 0.7 1.0 3.9 -1.3 -0.3 -1.2 -0.4 -0.7 -0.7 -0.8 -2.0 -0.3 -0.2 -1.3
Serious illness, injury or assault to yourself 0.2 0.3 0.9 -0.5 0.1 0.9 0.3 -0.2 0.7 -0.3 0.3 0.7 0.6 0.7
High blood pressure 0.3 0.8 1.3 -1.1 -0.1 -0.8 -1.1 -0.6 -0.9 1.1 -1.0 -1.1 -0.1 -1.1
Hayfever, allergic rhinitis or eczema 1.2 2.6 4.5 -0.5 -0.5 -2.0 -2.1 0.6 -1.9 1.7 -1.9 -1.6 -1.7 -1.9
Multivitamins +/- minerals 0.5 0.7 4.5 0.1 0.1 -0.4 -0.5 -2.1 -0.4 -0.6 -1.1 -0.2 0.4 -0.5
Stomach or abdominal pain in last month 0.1 0.1 0.4 -0.5 -0.1 0.2 0.0 0.0 -0.0 0.3 -0.4 0.1 -0.6 -0.3
Supplements: Glucosamine 0.2 0.3 1.1 1.0 -0.3 1.0 -0.8 -0.5 -0.2 -0.1 0.1 -0.3 -0.2 -0.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 0.6 1.4 0.3 1.5 -0.7 1.1 -1.1 0.8 1.3 1.0 1.2
Medication: Atenolol 1.5 1.9 3.6 -1.3 -0.8 -1.3 -1.5 -0.2 -1.7 1.7 -0.7 -1.9 -1.9 -1.2
Medication: Levothyroxine sodium 0.8 1.4 4.8 -0.6 -2.0 -0.6 -1.0 2.2 -1.1 0.4 -0.5 -1.0 -1.2 -0.6
Sitting height 0.1 0.8 2.9 0.7 0.6 0.9 0.1 1.7 0.2 -1.6 -0.7 0.6 0.6 -0.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.6 0.1 0.2 0.0 -0.2 0.1 0.2 -0.8 -0.5 0.2 0.0 -0.1
High blood pressure (mother) 0.4 0.6 1.4 0.6 0.9 0.3 0.9 0.8 0.7 -1.0 -0.1 0.8 1.2 0.4
Body mass index (BMI) 1.1 4.6 9.9 -1.3 -2.8 -1.8 -2.8 -1.4 -2.4 2.0 -0.8 -2.3 -3.1 -1.5
Impedance of leg (left) 0.1 0.6 3.9 0.5 0.5 0.2 1.0 2.0 0.4 0.3 0.1 0.0 1.2 0.0
Leg predicted mass (left) 0.1 0.6 3.4 -0.1 -0.6 0.8 -0.4 -1.2 -0.2 -1.9 0.1 0.6 -0.5 0.4
Trunk fat mass 0.6 2.6 5.9 -1.5 -2.4 -0.9 -2.3 -1.4 -1.9 0.9 -0.8 -1.7 -1.9 -1.2
Waist circumference 0.5 1.7 5.1 -0.5 -1.7 -0.2 -1.8 -1.7 -1.3 0.9 0.5 -1.1 -2.3 -0.3
Number of incorrect matches in round 0.4 0.7 3.0 0.2 -0.6 0.4 -1.2 1.7 -0.5 0.6 -0.4 -0.6 -1.0 -0.4
Past tobacco smoking 0.5 1.0 3.1 -1.3 1.8 -1.5 -0.0 -1.6 0.2 0.3 -0.4 -0.2 0.8 -0.5
Alcohol usually taken with meals 0.4 0.7 2.6 -0.1 -0.5 -1.6 -1.0 -0.3 -0.9 0.7 -0.9 -0.9 -0.6 -0.8
Nervous feelings 0.6 1.1 4.7 0.1 -0.9 -0.6 -2.2 -0.3 -0.9 0.2 -1.7 -0.8 -0.2 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 3.9 0.2 -0.3 -0.2 -0.6 2.0 0.4 0.8 -0.3 -0.2 0.1 -0.0
Hearing difficulty/problems with background noise 2.8 4.4 7.6 2.8 1.7 2.0 2.2 0.9 2.7 -1.4 2.5 2.5 0.5 2.5
Hair/balding pattern: Pattern 2 0.2 0.3 1.6 0.8 -0.3 0.4 0.1 0.3 0.0 -1.2 -0.2 0.4 0.3 -0.1
Had menopause 0.8 1.0 3.3 1.8 -0.4 0.6 0.1 0.7 0.7 -0.9 1.5 0.8 0.2 1.4
Had other major operations 1.7 2.1 8.3 -0.4 -0.8 -1.1 -1.5 0.5 -1.4 2.9 0.2 -2.2 -1.6 -1.2
Forced vital capacity (FVC) 0.3 1.3 5.3 -0.2 1.2 0.7 0.0 2.3 0.4 -1.8 -0.9 0.7 1.3 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.6 10.0 0.6 -1.5 -0.0 -2.3 0.9 -2.0 1.7 -0.3 -1.5 -3.2 -0.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.4 0.6 1.9 1.0 1.3 -0.2 0.8 -1.1 1.0 0.9 0.9 1.1
Qualifications: None of the above 5.0 10.8 21.2 -2.4 -4.6 -2.4 -3.7 0.5 -3.4 4.1 -2.6 -4.2 -2.8 -3.5
Financial difficulties in last 2 years 0.5 0.7 1.7 -0.1 0.3 1.3 0.4 -0.2 1.1 -0.8 0.2 1.1 1.3 0.9
Mouth/teeth dental problems 2.4 3.7 6.2 -2.3 -2.5 -2.3 -1.9 0.4 -2.1 0.7 -2.5 -1.8 -0.6 -2.3
Heart attack 1.1 1.4 3.4 -1.1 -1.1 -0.4 -1.7 0.2 -1.1 1.8 -1.1 -1.5 -1.1 -1.1
Allergy 1.8 4.2 7.7 0.1 2.8 2.0 2.5 -1.8 2.3 -1.6 1.7 1.8 2.7 2.0
Pain all over the body in last month 0.3 0.3 1.2 1.0 -0.7 0.4 -0.4 0.4 -0.2 1.1 0.1 -0.2 -0.5 -0.2
Diabetes (self-reported) 0.6 0.9 2.1 0.8 0.1 1.0 0.6 -1.4 0.7 -1.1 1.1 0.8 0.3 1.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.2 -0.2 0.8 -0.0 -0.2 -0.3 0.1 0.4 0.1 0.6 -1.1 0.2
Medication: Ramipril 2.2 2.8 5.5 -1.2 -1.6 -0.8 -1.9 -1.5 -2.3 1.4 -1.5 -2.2 -1.6 -1.7
Medication: Simvastatin 2.3 3.3 7.4 -0.3 -2.6 -0.4 -2.5 1.4 -1.8 2.1 -0.9 -2.0 -2.7 -1.3
Fluid intelligence score 0.5 1.1 2.9 -0.1 1.3 -0.4 0.9 -0.6 1.0 -1.7 1.3 1.2 0.4 1.3
Illnesses of siblings 0.5 0.7 2.2 -0.7 -0.6 0.5 -0.7 1.1 -0.6 -0.3 -1.5 -0.6 0.7 -1.1
Neuroticism score 0.2 0.5 2.4 1.1 -0.3 0.3 -0.9 1.5 0.3 0.0 -0.2 -0.0 -0.7 0.1
Weight 0.2 0.8 2.3 -0.4 -1.4 -0.0 -1.4 -0.9 -1.0 -0.3 -0.2 -0.6 -1.5 -0.3
Impedance of arm (right) 0.1 0.4 1.2 -1.0 0.2 -0.3 0.4 0.8 -0.5 -0.3 -1.1 -0.1 1.0 -0.6
Arm fat percentage (right) 1.6 6.3 11.3 -2.3 -3.0 -2.1 -3.2 -1.3 -3.0 2.3 -1.3 -2.7 -3.4 -2.0
Trunk fat-free mass 0.3 1.5 5.7 1.1 1.0 1.7 0.4 -0.3 0.7 -2.4 1.2 1.5 -0.1 1.3
Hip circumference 0.4 1.8 3.8 -0.9 -1.8 -0.7 -1.8 -1.1 -1.9 0.7 -0.9 -1.2 -2.0 -1.0
Time employed in main current job 1.7 2.0 3.9 -1.6 -2.0 -1.5 -1.2 -0.2 -1.5 1.0 -1.5 -1.6 -0.9 -1.8
Alcohol intake versus 10 years previously 1.0 1.5 3.6 1.9 0.3 1.2 1.2 -0.4 0.8 -1.1 1.7 1.6 -0.7 1.4
Father’s age at death 1.7 2.2 4.6 0.9 1.0 1.0 1.9 -1.3 1.8 -1.1 1.1 1.7 2.1 1.7
Worrier / anxious feelings 0.3 0.5 1.5 0.9 0.4 0.6 0.1 1.2 1.0 -0.5 0.5 0.8 -0.1 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 2.5 0.2 -0.1 0.8 -0.3 1.6 0.7 0.2 -0.7 -0.1 0.6 -0.4
Falls in the last year 0.2 0.3 1.3 -0.1 -1.2 0.9 -0.2 -0.5 0.0 0.7 0.1 -0.4 0.1 -0.3
Hair/balding pattern: Pattern 3 0.4 0.6 2.3 -0.2 -1.5 -0.5 -0.6 -0.5 -0.7 1.0 -0.3 -0.6 -1.0 -0.6
Number of live births 3.0 4.2 8.2 -1.0 -1.9 -1.6 -2.7 -1.4 -2.4 2.9 -1.3 -2.6 -2.0 -1.9
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 5.2 0.1 1.4 0.9 0.1 2.3 0.7 -1.4 -0.9 0.6 1.3 -0.2
Pulse rate 2.2 3.7 8.8 1.1 0.7 1.4 1.9 0.1 2.3 -3.0 2.0 2.6 1.5 2.4
Happiness 1.4 1.7 6.5 -1.0 -0.1 -0.3 -1.9 -0.8 -1.0 2.6 -1.0 -1.6 -0.9 -1.2
Noisy workplace 0.2 0.2 0.6 -0.2 0.5 -0.6 0.5 0.6 -0.6 -0.8 0.1 -0.3 -0.4 0.1
Qualifications: A levels/AS levels or equivalent 1.6 3.6 7.5 1.7 2.7 1.2 1.7 -0.5 1.7 -2.7 1.3 2.5 1.6 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.5 -0.3 0.8 0.7 -0.2 -1.2 -0.4 0.8 -0.4 -0.4 -0.9 -0.3
Mouth/teeth dental problems: Dentures 1.6 2.7 7.9 1.2 2.1 1.4 1.8 0.2 1.9 -0.3 2.8 1.6 -0.2 2.2
Asthma 4.3 8.4 13.7 -1.8 -3.7 -2.5 -3.3 1.1 -3.4 2.7 -2.5 -3.3 -3.2 -3.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.9 -0.5 0.4 -0.7 -1.1 1.5 -0.9 1.0 -0.3 -0.8 -2.0 -0.4
Medication: Cholesterol lowering 0.6 1.0 2.4 -1.5 -1.1 -0.4 -1.6 -0.6 -0.8 0.6 -1.0 -1.2 -0.3 -0.9
Depression (self-reported) 0.3 0.4 0.8 -0.7 -0.4 -0.3 -0.8 0.2 -0.4 0.4 -0.9 -0.5 -0.8 -0.6
Medication: Lansoprazole 0.6 0.7 2.2 0.5 -1.0 0.9 -1.5 -0.7 -0.9 0.7 -0.1 -0.5 -1.0 -0.3
Prospective memory result 0.9 1.1 4.5 -0.8 0.7 -0.2 1.2 -1.3 0.7 -1.3 -0.4 0.6 2.1 0.0
Lung cancer (father) 0.1 0.2 0.6 0.6 0.4 0.0 0.8 0.4 -0.1 -0.7 0.1 0.0 0.4 -0.0
Illnesses of mother 0.5 0.6 1.6 -1.2 -0.3 0.4 -0.5 0.4 -0.5 1.0 0.9 -0.7 -1.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 4.8 0.1 2.2 1.1 0.4 1.0 1.0 -1.7 -1.1 0.9 2.0 -0.2
Pulse wave Arterial Stiffness index 1.3 1.5 5.3 1.6 -0.1 1.8 0.5 0.1 0.9 -0.2 2.3 1.1 -0.5 1.8
Impedance of arm (left) 0.1 0.4 1.3 -0.9 -0.2 -0.1 0.5 0.6 -0.2 -0.0 -0.9 -0.1 1.1 -0.5
Arm fat mass (right) 0.9 3.6 8.1 -1.5 -2.4 -1.2 -2.6 -1.4 -2.3 1.3 -0.8 -1.9 -2.9 -1.4
Trunk predicted mass 0.2 1.4 5.1 1.1 0.8 1.6 0.3 -0.3 0.6 -2.3 1.1 1.4 -0.2 1.3
Standing height 0.7 7.2 19.9 1.8 2.3 3.4 2.5 1.1 2.5 -4.5 1.2 3.2 2.9 2.3
Length of working week for main job 1.8 2.0 5.8 2.4 0.3 1.1 1.0 2.4 0.9 0.7 1.7 1.3 -0.8 1.3
Exposure to tobacco smoke at home 0.9 1.0 4.2 1.0 0.8 2.0 1.0 -0.6 1.2 1.1 0.4 0.6 0.8 0.5
Breastfed as a baby 1.0 1.2 3.1 0.9 1.4 1.4 0.7 -0.2 1.2 -0.8 1.8 1.0 -0.0 1.5
Tense / ‘highly strung’ 0.1 0.1 0.3 0.1 0.1 0.2 -0.5 -0.5 0.2 -0.2 -0.3 0.4 -0.2 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.5 6.1 -0.2 -1.0 0.6 -1.7 1.5 -0.9 1.0 -0.6 -0.8 -2.5 -0.6
Hair/balding pattern: Pattern 4 0.2 0.5 1.8 0.1 1.3 0.1 0.2 1.0 0.6 1.2 0.6 0.2 -0.7 0.6
Birth weight of first child 0.0 0.1 0.4 -0.2 -0.2 0.1 -0.2 -0.6 -0.3 0.2 -0.5 -0.1 0.3 -0.2
Peak expiratory flow (PEF) 0.3 0.7 3.6 0.1 0.2 0.3 -0.4 1.4 0.8 -0.8 -0.9 0.4 1.9 -0.2
Pulse wave reflection index 0.6 0.7 1.9 1.1 0.1 1.2 0.4 1.0 0.5 0.7 1.4 0.4 -0.5 0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 3.1 0.6 -0.2 1.1 -0.6 0.3 -0.3 1.8 0.2 -0.3 -1.3 0.0
Loud music exposure frequency 0.3 0.4 1.4 0.9 -0.0 1.2 0.5 0.3 0.1 -0.9 0.3 0.5 -0.0 0.5
Qualifications: O levels/GCSEs or equivalent 0.6 1.0 3.2 1.1 1.8 0.8 0.9 -0.0 0.4 -1.2 1.0 0.9 0.4 1.1
Mouth/teeth dental problems: Bleeding gums 2.3 3.0 4.3 1.9 1.4 1.5 2.1 -1.1 1.5 -1.9 2.0 1.8 1.5 2.1
Blood clot in the leg (DVT) 0.3 0.4 2.4 -0.1 -1.6 0.4 0.8 0.2 -0.1 -0.2 0.3 0.5 -0.5 0.1
Medication: Paracetamol 0.3 0.5 2.1 0.3 -0.0 -0.3 -0.6 0.8 -0.0 1.4 0.4 -0.3 -1.2 0.0
Headache pain in last month 1.9 3.2 6.4 -0.6 -1.9 -0.7 -2.5 2.0 -2.2 1.7 -1.2 -2.1 -2.2 -1.6
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 4.6 2.1 1.4 0.6 1.8 1.0 1.3 -1.1 1.3 1.7 0.5 1.4
Glaucoma (self-reported) 0.7 0.8 3.3 0.4 -0.2 -0.6 0.4 -1.3 0.7 -1.8 0.4 1.0 1.1 0.8
Gout (self-reported) 0.1 0.1 0.5 0.4 -0.1 -0.1 -0.0 -0.4 0.3 -0.7 0.2 0.4 -0.2 0.3
Hypothyroidism/myxoedema (self-reported) 2.0 4.0 7.5 -1.7 -2.7 -2.0 -2.0 2.0 -2.3 1.2 -1.7 -2.3 -1.7 -2.0
Medication: Amlodipine 0.6 0.8 2.6 -0.6 0.1 0.1 -0.6 -0.9 -0.9 1.6 0.1 -1.1 -1.6 -0.6
Medication: Ventolin 100micrograms inhaler 2.0 2.6 5.5 -1.3 -2.3 -2.2 -1.6 -0.2 -1.7 1.1 -1.3 -1.8 -1.5 -1.7
Birth weight 0.8 1.8 3.9 1.0 1.9 0.8 1.8 -0.3 1.2 -1.1 1.2 1.2 2.0 1.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 2.2 0.0 0.4 0.5 -0.1 -1.5 0.2 -0.8 -0.3 0.3 0.7 0.0
High blood pressure (siblings) 1.9 2.7 6.8 0.5 1.9 -0.1 2.1 -2.6 1.7 -1.1 1.7 1.5 1.8 1.7
Forced vital capacity (FVC), Best measure 0.3 1.1 2.8 0.0 1.6 1.1 0.2 1.2 0.6 -1.7 -1.0 0.8 1.5 -0.2
Body fat percentage 1.0 4.0 7.7 -1.8 -2.8 -1.5 -2.6 -1.3 -2.3 1.9 -0.9 -2.3 -2.3 -1.6
Leg fat percentage (right) 0.6 2.1 3.9 -1.2 -1.6 -1.2 -2.0 -1.1 -1.4 1.6 -0.1 -1.8 -1.9 -0.8
Arm fat-free mass (right) 0.2 1.2 3.6 1.5 -0.0 1.5 0.1 -0.4 0.6 -1.9 1.2 1.2 -0.4 1.1
Exposure to tobacco smoke outside home 0.5 0.7 2.5 0.4 -1.0 1.1 0.1 1.6 0.2 0.2 1.1 0.4 -0.9 0.8
Comparative body size at age 10 0.8 2.1 4.2 -1.3 -0.6 -1.6 -1.4 0.7 -1.6 1.3 -2.0 -2.0 -0.2 -2.1
Number of full brothers 0.3 0.4 1.0 0.9 -0.5 0.5 0.1 0.3 0.3 0.3 1.0 0.4 -0.9 0.9
Worry too long after embarrassment 1.0 1.6 5.0 2.2 0.7 0.2 0.6 1.4 1.5 -1.2 1.3 1.4 -0.0 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.1 -0.6 0.2 0.6 0.1 0.9 0.4 0.5 0.7 0.3 -1.1 0.5
Wheeze or whistling in the chest in last year 1.3 2.3 9.7 -0.3 -3.1 0.7 -1.4 1.0 -1.5 1.9 -0.4 -1.4 -1.9 -1.0
Number of children fathered 1.4 1.6 4.6 -0.2 -1.0 -0.9 -0.6 1.1 -1.4 2.1 -1.0 -1.5 -1.4 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 2.9 1.2 1.0 1.3 1.1 -0.6 1.3 -1.6 1.1 1.7 1.3 1.5
Age at first live birth 1.1 2.0 6.8 -0.1 1.8 2.2 0.7 0.2 1.3 -2.0 -0.5 1.0 2.6 0.3
Pulse wave peak to peak time 1.0 1.2 4.4 -1.3 0.1 -1.6 -0.4 0.3 -0.7 0.1 -2.1 -0.9 0.6 -1.6
Health satisfaction 1.5 1.9 5.4 -0.5 -1.2 -0.0 -2.3 1.4 -1.2 1.7 -1.2 -1.6 -1.4 -1.4
Shortness of breath walking on level ground 1.1 1.3 6.5 0.7 -1.1 -0.1 -1.4 1.1 -0.6 1.3 0.7 -0.6 -2.6 -0.1
Qualifications: College or University degree 2.5 8.0 21.0 2.3 4.6 2.3 2.8 -0.4 2.8 -3.1 2.0 3.4 2.8 2.7
Eye problems/disorders: None of the above 2.9 3.4 6.0 -1.6 -1.2 -2.0 -1.9 0.7 -2.4 1.6 -2.4 -2.3 -1.1 -2.1
Mouth/teeth dental problems: Loose teeth 3.0 3.5 7.2 1.5 1.4 2.0 1.5 -0.4 2.6 -1.4 2.5 2.3 0.7 2.7
Emphysema/chronic bronchitis 1.1 1.3 3.3 1.6 -1.2 0.8 -0.1 1.8 1.2 -0.8 1.4 0.8 -0.3 1.1
Medication for pain relief, constipation, heartburn 1.7 3.0 10.1 1.1 1.0 0.6 1.8 -1.6 1.3 -2.9 -0.7 1.7 3.2 0.6
Neck or shoulder pain in last month 0.8 1.1 2.7 -0.4 -1.2 -0.5 -0.9 1.6 -0.8 1.5 -1.1 -0.8 -1.0 -0.9
Medication: Blood pressure 1.1 2.0 4.1 -2.0 -2.0 -0.5 -1.4 -0.7 -1.6 1.5 -0.9 -1.8 -0.7 -1.4
Angina (self-reported) 1.0 1.3 2.8 -1.3 -1.6 -0.7 -1.2 -1.0 -0.6 1.7 -1.2 -1.2 -0.4 -1.1
Migraine (self-reported) 1.7 2.1 4.4 -1.9 -0.9 -1.3 -1.3 -0.5 -1.6 2.1 -1.0 -1.8 -0.9 -1.8
Medication: Ibuprofen 0.6 0.8 3.8 0.3 0.0 -0.1 -0.8 2.0 -0.3 0.8 0.1 -0.2 -1.8 0.2
Medication: Allopurinol 0.1 0.2 0.7 0.8 -0.7 0.4 -0.1 0.0 0.2 -0.3 0.4 0.1 -0.3 0.4
Medication: Omeprazole 1.3 1.5 5.1 -0.6 -2.3 0.6 -0.5 -0.5 -1.7 1.6 -0.0 -1.2 -1.8 -0.7
Medication: Seretide 50 evohaler 0.2 0.2 1.8 0.2 -0.2 -0.0 0.4 -1.4 0.3 -0.4 0.1 0.3 0.3 0.1
Mean time to correctly identify matches 5.1 9.7 15.1 3.6 3.5 3.5 3.2 0.1 3.3 -2.2 3.8 3.5 1.3 3.9
Heart disease (mother) 0.3 0.3 1.4 0.4 0.9 -1.2 -0.2 0.3 0.3 -0.2 0.5 0.3 -0.6 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 2.1 -0.6 -0.1 -0.6 -0.3 -1.1 -0.5 -1.4 0.2 0.0 0.5 0.2
Whole body fat mass 0.8 3.2 6.4 -1.6 -2.3 -1.1 -2.5 -1.7 -2.1 1.0 -0.8 -1.8 -2.3 -1.3
Leg fat mass (right) 0.5 1.9 4.5 -1.3 -1.8 -0.8 -1.9 -1.4 -1.5 0.9 -0.0 -1.4 -2.1 -0.7
Arm predicted mass (right) 0.3 1.6 4.2 1.7 0.1 1.8 0.5 -0.3 0.9 -2.0 1.6 1.4 -0.3 1.5
Pulse rate, automated reading 1.5 4.9 11.8 1.6 1.6 0.6 2.0 -0.8 2.2 -3.4 2.7 2.7 1.8 2.9
Alcohol intake frequency. 3.6 8.4 12.5 -2.3 -3.1 -2.4 -3.0 -1.0 -3.4 3.2 -2.7 -3.5 -3.0 -3.3
Comparative height size at age 10 0.2 1.2 3.2 1.1 -0.3 1.8 0.6 0.0 1.0 -1.8 0.0 1.3 1.5 0.7
Number of full sisters 0.3 0.3 1.6 -0.0 1.0 -0.5 0.1 0.1 -0.4 0.5 0.3 0.0 -1.3 0.1
Suffer from ‘nerves’ 0.4 0.6 2.4 0.8 -0.1 0.5 -1.0 1.5 0.7 -0.9 -0.2 0.7 -0.2 0.4
Overall health rating 0.6 1.3 4.2 -0.5 -2.1 -0.0 -1.3 -0.3 -1.1 0.5 -1.3 -1.2 -1.2 -1.4
Chest pain or discomfort 1.9 2.8 5.2 2.3 -0.1 2.2 1.5 1.6 2.0 -0.8 1.8 1.8 -0.3 2.1
Had major operations 0.3 0.4 1.5 -0.5 -0.5 0.0 -0.2 -1.2 -0.2 1.0 -0.6 -0.4 -0.3 -0.7
Age at last live birth 0.6 0.9 3.0 0.3 1.2 1.5 -0.1 -0.8 0.7 -0.9 -1.0 0.4 1.7 -0.3
Family relationship satisfaction 0.4 0.5 2.4 -0.0 0.9 1.5 -0.1 0.4 0.9 0.6 -0.6 0.6 0.5 0.0
Leg pain on walking 0.9 1.1 4.2 1.8 0.5 1.6 0.4 2.0 0.4 0.4 0.9 0.4 -0.7 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.2 1.1 0.1 1.1 0.9 -0.0 1.0 -0.8 1.3 1.2 -0.1 1.5
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.1 1.0 -0.9 0.8 0.8 1.3 0.8 -0.2 1.4 1.2 -0.6 1.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.0 1.4 -0.0 0.1 0.8 1.2 0.4 -0.7 0.3 0.7 0.4 0.4
Medication: Aspirin 0.8 1.1 3.1 -1.4 -1.0 -0.4 -1.8 -0.7 -0.9 1.0 -0.8 -1.2 -0.5 -1.1
Supplements: Vitamin C 1.2 1.4 4.8 1.4 0.8 0.8 0.8 0.5 1.0 -2.2 0.9 1.7 0.4 1.4
Knee pain experienced in last month 0.5 0.7 2.4 1.5 -1.0 0.7 0.5 1.4 0.1 0.2 0.8 0.1 -0.8 0.7
Hypertension (Self-reported) 0.3 1.0 1.5 -1.2 -0.1 -1.0 -1.1 -0.8 -1.0 1.2 -1.0 -1.2 -0.3 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.2 1.1 -0.5 1.5 0.2 0.0 -0.1 0.4 0.8 0.5 -1.1 0.7
Illnesses of father: Heart disease 0.3 0.4 1.3 1.0 1.0 -0.2 -1.1 0.6 0.3 -0.3 -0.3 0.5 -0.3 0.3
Illnesses of siblings: Diabetes 0.7 0.9 3.2 0.6 0.3 -0.1 -0.2 -1.2 0.1 -0.2 1.3 0.9 -1.8 1.3
Smoking status: Previous 0.6 0.9 4.8 1.1 -2.2 1.2 -0.7 0.7 -0.7 -0.1 -0.4 -0.2 -0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 1.0 -0.0 0.4 0.4 0.2 0.5 0.5 -0.8 0.0 0.3 1.0 0.2
Whole body fat-free mass 0.1 0.9 4.1 0.7 -0.0 1.4 0.0 -0.6 0.2 -2.0 0.8 1.0 -0.5 0.9
Leg fat-free mass (right) 0.1 0.6 2.6 -0.1 -1.0 0.7 -0.4 -1.3 -0.3 -1.6 0.1 0.5 -0.6 0.2
Arm fat percentage (left) 1.6 6.3 10.6 -2.3 -3.2 -2.0 -3.3 -1.6 -2.9 2.3 -1.3 -2.8 -3.1 -2.0
Average weekly red wine intake 0.9 1.4 5.0 0.2 1.4 0.7 0.7 -2.2 1.1 -1.3 0.1 1.2 1.5 1.0
Handedness (chirality/laterality): Left-handed 1.7 2.0 4.8 -0.5 -1.6 -1.3 -1.2 0.8 -1.7 1.8 -1.0 -1.4 -2.2 -1.4
Mood swings 1.8 3.2 5.9 -0.8 -1.7 -1.1 -1.9 2.3 -1.3 2.4 -1.7 -2.0 -1.8 -1.9
Loneliness, isolation 0.2 0.3 1.3 -1.1 1.0 -0.2 -0.1 -0.0 0.2 0.1 -0.2 -0.2 0.6 -0.2
Long-standing illness, disability or infirmity 0.3 0.4 0.9 0.5 -0.8 -0.5 -0.9 -0.3 -0.4 -0.0 -0.9 -0.7 0.5 -0.7
Ever had bowel cancer screening 0.1 0.2 0.6 0.1 0.3 0.3 0.2 0.3 0.4 0.3 0.8 0.3 -0.1 0.6
Diabetes diagnosed by doctor 0.5 0.8 1.9 0.9 0.5 0.9 0.6 -1.2 0.7 -0.7 1.4 0.8 -0.3 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.0 -0.1 0.6 -0.1 0.9 -0.2 1.0 -0.4 -0.1 0.7 1.0 0.4
Friendships satisfaction 1.2 1.4 4.3 -1.1 1.8 0.3 -0.8 -1.9 0.4 0.1 -1.5 0.3 2.1 -0.5
Qualifications: nursing, teaching 2.8 4.4 7.5 1.5 2.6 1.5 2.0 -0.0 2.5 -2.7 1.8 2.7 1.8 2.3
Commuting to job workplace: Walk 1.4 1.5 7.9 -0.9 -0.5 -2.8 -1.5 0.0 -0.8 0.2 -1.4 -1.1 -0.3 -1.2
Eye problems/disorders: Cataract 0.3 0.3 1.2 0.3 0.2 1.1 0.5 -0.4 0.6 -0.5 0.7 0.4 0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 5.9 0.6 -1.5 0.4 -1.3 0.9 -1.5 2.0 -0.7 -1.5 -2.4 -1.1
Medication for cholesterol 2.5 3.8 7.8 1.4 1.8 2.0 2.8 1.7 2.2 -1.6 1.8 2.3 1.3 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 8.6 1.3 0.3 1.3 1.6 1.6 1.4 -0.7 2.9 1.2 -0.2 2.3
Back pain experienced in last month 1.4 2.1 6.7 0.2 -2.0 0.6 -0.8 2.6 -1.4 1.1 -0.3 -1.0 -2.6 -0.7
Mineral and other dietary supplements 0.8 1.1 3.5 0.8 0.8 0.8 1.9 -0.4 1.3 -0.1 1.1 1.3 0.5 1.1
Breast cancer (self-reported) 4.6 5.5 8.0 1.6 2.8 2.2 2.7 0.0 2.5 -2.6 2.1 2.7 2.6 2.4
Asthma (self-reported) 4.4 8.8 16.4 -1.7 -4.0 -2.6 -3.6 1.3 -3.5 2.6 -2.5 -3.4 -3.2 -3.2
Osteoporosis (self-reported) 0.3 0.3 0.7 0.5 -0.0 0.7 0.6 -0.4 0.5 -0.8 0.2 0.8 0.8 0.3
Osteoarthritis (self-reported) 0.6 0.8 2.8 0.4 -1.7 0.9 -0.2 1.6 -0.1 1.2 0.1 -0.3 -1.2 -0.1
Medication: Aspirin 0.8 1.1 3.5 -1.1 -1.4 -0.0 -1.9 -0.5 -0.9 1.0 -0.8 -1.2 -0.6 -1.0
Medication: Gliclazide 0.3 0.4 1.0 -0.6 0.3 -0.5 -0.7 -0.9 -0.1 -0.2 0.9 -0.0 -1.0 0.7
Illnesses of father: None of the above (group 1) 0.6 0.8 3.0 0.3 -1.1 -0.4 1.6 0.3 0.2 0.5 1.7 0.1 -0.6 0.8
Smoking status: Current 0.3 0.4 2.6 -0.4 0.1 -0.2 0.2 1.6 -0.1 0.9 0.6 -0.5 -0.8 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 4.0 -0.2 1.6 -0.2 0.3 -0.4 1.1 -0.5 -0.7 0.4 2.0 0.0
Whole body water mass 0.2 0.9 4.2 0.8 0.1 1.3 0.0 -0.5 0.2 -2.0 0.8 1.1 -0.5 0.9
Leg predicted mass (right) 0.1 0.6 2.7 -0.0 -0.9 0.8 -0.3 -1.2 -0.2 -1.6 0.2 0.6 -0.5 0.3
Arm fat mass (left) 1.0 4.0 7.7 -1.7 -2.6 -1.3 -2.7 -1.6 -2.4 1.5 -0.9 -2.0 -2.8 -1.5
Number of self-reported non-cancer illnesses 3.7 6.4 13.9 -1.6 -3.7 -2.1 -2.8 0.6 -2.7 3.0 -1.7 -2.6 -3.2 -2.3
Average weekly champagne plus white wine intake 2.1 2.8 5.5 1.1 2.3 1.9 1.5 -1.1 2.0 -1.1 1.9 2.0 0.5 2.1
Miserableness 0.9 1.6 4.5 -0.1 -1.2 0.6 -1.6 1.7 -0.8 1.0 -1.1 -1.2 -2.1 -1.0
Guilty feelings 0.9 1.4 2.8 1.7 1.7 1.3 0.8 1.6 1.4 0.1 1.2 0.5 0.4 1.1
Wears glasses or contact lenses 0.7 0.8 2.7 0.9 -0.1 0.1 -1.4 0.9 -0.2 1.0 0.9 -0.1 -1.7 0.6
Ever taken oral contraceptive pill 0.2 0.3 0.7 0.5 -0.3 0.7 -0.5 -0.2 -0.3 -0.5 -0.8 -0.1 0.6 -0.7
Hearing aid user 0.3 0.3 0.8 -0.3 0.6 0.2 -0.2 -0.8 -0.6 0.9 -0.0 -0.6 -0.9 -0.3
Mother’s age at death 0.6 0.7 3.6 -0.2 0.0 0.1 0.7 -1.6 0.8 -0.5 0.0 0.4 1.9 0.3
Financial situation satisfaction 2.3 2.8 6.7 -1.3 -1.6 0.2 -2.0 1.5 -1.7 2.1 -1.1 -1.8 -2.6 -1.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.0 -1.2 -0.1 -0.9 -1.4 -0.2 -0.9 0.1 -1.3 -0.7 -0.4 -1.0
Commuting to job workplace: Public transport 2.2 2.6 6.0 1.2 2.5 1.5 1.4 -0.7 2.0 -1.0 1.8 1.7 1.4 1.9
Eye problems/disorders: Glaucoma 0.2 0.3 1.1 -0.3 0.2 -0.8 -0.5 -1.0 0.0 -0.8 -0.1 0.1 0.7 -0.0
Medication: Blood pressure 0.3 0.6 1.2 -0.5 -0.4 -1.1 -1.1 -1.0 -0.9 0.5 -0.5 -0.8 -0.7 -0.8
Pain type(s) experienced in last month: Hip pain 1.2 1.6 5.5 0.5 -1.9 1.1 -0.7 1.6 -0.5 1.7 0.5 -0.7 -2.4 -0.1
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.2 -1.4 -0.5 -1.1 -1.5 0.8 -1.0 0.4 -0.9 -1.1 -0.3 -0.9
High cholesterol (Self-reported) 0.2 0.3 1.0 0.5 -0.8 -0.3 -0.4 0.3 0.2 0.3 0.7 -0.1 -1.0 0.4
Medication: Bendroflumethiazide 1.8 2.8 4.7 -0.9 -1.1 -2.1 -1.7 -1.9 -2.1 1.9 -0.5 -1.8 -2.2 -1.3
Medication: Paracetamol 0.5 0.8 3.5 0.6 -0.0 -0.2 -0.7 0.9 -0.2 1.7 0.5 -0.3 -1.9 0.1
Medication: Lisinopril 0.1 0.2 0.8 -0.4 -0.2 0.9 -0.2 0.3 0.5 0.4 0.1 -0.1 0.5 -0.2
Medication: Atorvastatin 0.2 0.2 1.0 0.3 0.2 0.1 0.2 -0.4 0.2 -0.3 1.0 0.4 -0.3 0.7
Illnesses of father: High blood pressure 0.3 0.3 0.7 -0.4 0.5 0.4 -0.5 -0.8 0.2 -0.8 -0.8 0.4 0.6 -0.2
Alcohol drinker status: Never 0.6 0.8 2.9 0.4 -0.0 0.0 -1.2 1.5 -0.4 0.6 0.2 -0.9 -1.7 -0.4
Ever smoked 1.4 2.4 7.3 2.1 -0.4 2.4 1.3 2.7 1.0 -0.6 1.7 1.1 -0.2 1.5
Basal metabolic rate 0.1 0.6 2.7 0.4 -0.4 1.0 -0.4 -0.7 -0.2 -1.6 0.4 0.6 -0.8 0.5
Leg fat percentage (left) 0.7 2.6 4.9 -1.3 -2.2 -1.3 -2.0 -1.4 -1.6 1.8 -0.2 -2.0 -2.0 -1.0
Arm fat-free mass (left) 0.1 0.7 2.6 1.1 -0.2 1.2 -0.0 -0.2 0.2 -1.6 0.9 0.9 -0.6 0.8
Number of operations (self-reported) 0.7 1.1 6.7 0.7 -0.3 0.2 0.0 -0.6 -0.1 2.6 0.8 -0.6 -1.7 0.1
Average weekly beer plus cider intake 0.7 1.1 2.6 -1.5 0.4 -1.5 -0.5 -0.0 -0.3 0.0 -1.6 -0.7 1.3 -1.4
Irritability 0.4 0.7 2.9 1.7 -1.2 0.9 0.3 1.1 0.5 0.2 0.1 0.5 -0.6 0.5
Risk taking 1.4 2.1 3.9 1.4 1.8 1.1 1.4 -1.0 1.6 -0.3 2.0 1.7 0.6 1.9
Ever had prostate specific antigen (PSA) test 1.5 1.7 3.3 0.4 1.8 1.1 1.3 -1.2 1.8 -0.7 0.9 1.7 1.3 1.3
Fractured/broken bones in last 5 years 0.4 0.5 2.2 0.0 -0.8 -0.7 -0.4 -0.7 0.2 0.7 0.9 0.1 -1.5 0.5
Age started oral contraceptive pill 0.6 0.8 6.9 0.4 -1.1 -0.1 -0.1 -2.6 -0.5 0.4 -0.1 0.1 0.2 -0.2
Diastolic blood pressure, automated reading 0.1 0.4 2.0 -0.3 -0.1 -1.4 -0.9 -1.1 0.2 -0.5 -0.1 -0.0 0.5 0.3
Ever depressed for a whole week 0.6 0.7 1.9 0.6 1.0 0.7 1.1 0.2 0.8 -0.0 1.4 0.9 -0.4 1.2
Unable to work because of sickness or disability 0.2 0.2 1.3 -0.2 0.2 -0.1 -0.3 -0.4 0.2 0.5 -0.6 -0.4 1.1 -0.3
Commuting to job workplace: Cycle 1.7 2.0 3.8 1.4 1.9 1.1 0.8 -0.5 1.6 -2.0 0.3 1.9 1.8 1.1
Myopia 0.4 0.6 2.3 0.7 0.8 1.5 -0.2 -1.1 0.2 0.0 0.6 0.4 -0.7 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.1 1.4 0.4 1.0 1.4 0.9 1.0 -1.3 1.4 1.4 0.2 1.3
Cholesterol lowering medication 0.8 1.2 4.4 0.0 -1.4 -1.1 -1.6 -0.3 -1.0 1.2 -0.0 -0.9 -2.1 -0.4
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 6.3 -0.4 -1.5 0.6 -1.1 0.3 -1.8 2.4 0.1 -1.3 -2.5 -0.8
Pain experienced in last month 3.1 5.2 10.8 0.1 2.5 0.1 2.2 -2.9 2.7 -2.6 1.7 2.3 3.3 2.0
Supplements: Calcium 0.6 0.7 2.2 0.6 -0.7 -0.1 0.2 1.5 0.8 -1.1 0.9 0.7 0.4 0.9
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 1.0 0.1 0.9 0.1 0.7 0.8 -0.4 0.2 0.7 0.5 0.5
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.6 -1.1 -1.1 -0.6 -1.6 -0.2 -1.1 1.9 -1.0 -1.4 -1.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.9 0.2 -1.4 0.7 1.0 0.0 0.2 -0.4 0.7 0.7 -0.2 0.5
Heart disease (siblings) 0.5 0.6 2.4 0.5 -0.3 -0.1 -0.6 1.2 -0.1 0.7 0.9 -0.1 -1.5 0.4
Alcohol drinker status: Previous 0.8 0.9 1.7 -1.1 -0.7 -0.7 -0.9 -0.5 -1.2 1.2 -0.3 -1.1 -1.3 -0.9
Pack years of smoking 0.9 1.3 4.0 -0.3 0.4 -0.1 1.1 -1.0 1.3 -1.5 2.0 1.2 0.3 1.5
Impedance of whole body 0.1 0.5 2.5 0.0 0.1 0.1 0.8 1.6 0.1 0.2 -0.5 0.1 1.2 -0.3
Leg fat mass (left) 0.6 2.4 5.0 -1.4 -2.2 -1.0 -2.0 -1.6 -1.7 1.1 -0.2 -1.7 -2.1 -0.9
Arm predicted mass (left) 0.2 0.9 2.9 1.3 -0.2 1.2 0.0 -0.4 0.3 -1.7 1.1 1.0 -0.8 0.9