Hub : Genes

PJA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0885	0.0370	1.4e-03	0.021	NA	-0.001	NA	0.008	1.1e-02	NA	0.36000	NA	0.08800
2	GTEx	Whole Blood	0.0500	0.0260	5.6e-03	-0.001	NA	0.004	NA	0.000	4.0e-01	NA	0.12000	NA	0.36000
3	METSIM	Adipose	0.0395	0.0197	3.7e-03	0.000	0.006	0.000	0.006	0.001	3.0e-01	3.9e-02	0.33000	0.03700	0.18000
4	NTR	Blood	0.0393	0.0159	8.8e-05	0.018	0.009	0.008	0.009	0.011	1.4e-06	5.0e-04	0.00096	0.00034	0.00016
5	ROSMAP	Brain Pre-frontal Cortex	0.0767	0.0321	4.5e-04	0.000	0.022	0.023	0.023	0.010	2.9e-01	5.9e-04	0.00051	0.00055	0.01500
6	TCGA	Breast Invasive Carcinoma	0.0167	0.0085	4.3e-05	0.010	0.015	0.008	NA	0.009	2.8e-03	3.2e-04	0.00650	NA	0.00470
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0255	0.0165	3.1e-03	0.037	0.015	0.022	NA	0.027	4.9e-05	7.9e-03	0.00130	NA	0.00042
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0448	0.0237	2.6e-04	0.024	0.035	0.018	NA	0.022	8.7e-04	6.7e-05	0.00370	NA	0.00130
9	TCGA	Brain Lower Grade Glioma	0.0199	0.0138	9.6e-03	0.001	0.007	0.001	NA	0.001	2.6e-01	4.3e-02	0.26000	NA	0.24000
10	TCGA	Lung Adenocarcinoma	0.0239	0.0153	7.8e-03	-0.002	0.002	-0.001	NA	-0.002	7.3e-01	1.6e-01	0.52000	NA	0.72000
11	TCGA	Prostate Adenocarcinoma	0.0235	0.0154	8.2e-03	0.001	0.002	-0.002	NA	-0.002	2.3e-01	1.9e-01	0.81000	NA	0.66000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.2	0.5	0.0	0.7	0.4	0.1	-0.6	0.3	-0.4	0.0	0.4	0.5	0.3
Bipolar Disorder or Schizophrenia	2.0	4.8	13.3	0.7	3.6	1.9	2.2	-2.4	2.0	-2.1	1.0	2.1	2.8	1.7
Depressed Affect (Nagel 2018)	0.7	1.4	2.4	-0.6	-1.0	0.0	-1.4	1.5	-0.8	1.4	-1.6	-1.4	-1.1	-1.4
Depression (Nagel 2018)	0.3	0.4	0.7	-0.5	0.8	0.8	0.3	0.9	0.7	0.8	0.6	0.2	-0.5	0.5
Intelligence (Savage-Jansen 2018)	1.3	3.9	7.3	0.6	2.7	0.8	2.2	-2.0	1.7	-2.3	2.2	2.3	1.3	2.3
Neuroticism (Nagel 2018)	0.2	0.6	1.6	0.3	-0.7	0.4	-1.3	1.2	-0.3	0.5	-0.9	-0.6	-0.8	-0.5
Schizophrenia (2018)	2.9	6.0	14.4	0.9	3.8	2.1	2.7	-2.6	2.3	-2.4	1.4	2.3	3.2	2.0
Schizophrenia vs Biploar Disorder	0.4	0.5	2.4	-1.0	1.6	0.4	1.0	-0.1	0.7	-0.2	0.5	0.4	0.4	0.2
Worry (Nagel 2018)	0.3	0.7	1.8	0.9	0.4	1.3	-0.4	0.0	1.0	-1.3	0.1	1.2	0.6	0.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	0.5	-0.2	0.5	-0.2	0.1	-0.6	-0.3	-0.6	0.0	-0.5	-0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.9	0.6	-0.2	0.4	0.3	0.7	0.8	0.1	0.2	0.2	1.0	0.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.6	-0.7	0.5	-0.7	0.3	-0.4	0.3	-0.9	-0.3	-0.1	-0.4
Crohns Disease (2017)	0.5	1.0	4.5	-1.0	-2.1	-0.2	-0.1	0.9	-1.0	0.1	-0.2	-0.5	-1.8	-0.6
Irritable Bowel Disease (IBD)	1.7	4.1	9.0	-2.4	-3.0	-2.0	-1.5	-0.3	-2.5	1.3	-1.2	-1.9	-2.8	-1.9
Ulcerative Colitis (UC)	2.3	4.4	7.3	-2.4	-2.2	-2.4	-2.0	-1.0	-2.7	1.4	-1.7	-2.2	-2.2	-2.2
Major Depression (MDD)	1.1	1.4	3.0	1.7	-0.5	1.7	0.6	0.8	1.2	-0.7	1.5	1.1	-0.6	1.4
Reaction Time	7.1	13.5	20.3	4.1	3.9	4.2	3.8	0.4	3.9	-3.1	4.2	4.2	1.8	4.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.6	-0.5	1.4	-0.1	0.7	-1.6	0.8	-1.1	1.0	1.1	0.7	1.3
Breast Cancer	0.6	1.3	2.7	1.4	1.6	-0.0	0.9	-0.8	1.2	-1.5	1.5	1.0	0.3	1.2
Ovarian Cancer	0.9	1.2	4.6	-0.1	2.2	0.8	1.0	-0.0	1.0	-1.4	1.0	0.8	1.0	0.8
Prostate Cancer	0.3	0.4	0.7	0.8	-0.1	-0.6	0.5	0.5	0.8	-0.1	0.9	0.6	0.1	0.9
Age at First Birth	1.7	2.4	11.7	-1.7	2.3	0.2	0.5	-3.4	0.2	-0.7	-1.2	0.0	2.1	-0.6
Bipolar Disorder (2011)	0.6	0.5	1.4	-0.2	1.1	0.7	1.2	-0.1	0.6	-0.5	1.0	0.8	-0.2	0.8
Body Mass Index (BMI) (2010)	2.6	3.5	7.6	-2.1	-1.6	-2.3	-1.7	-0.3	-2.1	1.8	-0.9	-2.1	-2.8	-1.6
Coronary Artery Disease (CAD)	0.1	0.2	0.5	0.2	-0.3	-0.5	-0.3	-0.7	-0.2	0.2	0.7	-0.2	-0.1	0.4
Crohns Disease (2012)	0.6	1.0	4.6	-1.1	-1.7	-0.2	-0.1	0.4	-0.6	0.9	0.3	-0.4	-2.1	-0.3
Mean Putamen Volume	0.4	0.4	0.8	-0.1	0.5	0.6	0.9	-0.0	0.6	-0.8	0.6	0.7	0.7	0.9
Fasting Glucose	1.0	1.2	7.8	0.8	2.8	0.7	0.9	-0.5	0.6	-0.6	0.4	0.8	1.0	0.6
HbA1C	1.0	1.1	2.3	-1.0	-0.3	-1.5	-0.8	-0.4	-1.1	1.5	-0.3	-1.3	-1.2	-0.9
HDL Cholesterol	0.8	1.3	2.6	1.2	0.7	0.3	1.5	1.5	1.2	-1.0	0.8	1.6	0.7	1.1
LDL Cholesterol	1.4	2.1	4.7	-2.2	-0.3	-1.2	-2.1	-0.8	-1.9	1.0	-1.1	-1.8	-1.3	-1.3
Lupus	0.2	0.3	1.0	-0.3	0.5	0.6	-0.7	0.4	0.2	-1.0	-0.3	0.5	-0.0	0.3
Neuroticism (2016)	0.4	0.6	2.1	-0.6	-1.2	-0.2	-1.1	-0.6	-0.1	0.8	-0.5	-0.3	-1.5	-0.5
Primary Biliary Cirrhosis	0.2	0.3	1.0	0.1	-0.1	1.0	0.7	-0.1	0.0	0.8	0.8	-0.1	-0.4	0.3
Rheumatoid Arthritis	0.4	0.6	1.4	-0.5	-0.3	-0.1	-0.6	-0.3	-1.2	0.7	-1.1	-1.2	-0.2	-1.1
Schizophrenia (2014)	2.1	4.7	13.2	0.6	3.6	1.6	2.2	-2.4	1.9	-2.6	1.4	2.2	2.1	1.8
Triglycerides	0.3	0.5	1.4	-1.2	-0.7	-0.4	-1.0	-0.2	-0.8	0.3	-0.3	-0.6	-0.8	-0.3
Type 2 Diabetes (T2D) (2012)	1.7	1.9	6.2	1.0	1.6	0.6	1.1	-0.0	1.5	-2.5	0.9	1.8	1.2	1.4
Ulcerative Colitis	2.9	4.2	7.3	-2.7	-1.9	-2.1	-1.6	-0.4	-2.1	2.4	-1.2	-2.6	-2.2	-2.2
Blood Eosinophil Count	0.7	5.1	11.8	-1.2	-1.9	-2.0	-3.4	0.3	-2.9	1.6	-1.6	-2.9	-2.8	-2.3
Blood Platelet Count	0.3	3.6	14.4	-0.2	2.6	-0.1	1.7	-1.4	1.8	-2.6	0.3	1.9	3.8	0.8
Blood Red Count	0.8	7.5	10.2	-3.2	-1.8	-3.0	-3.2	-2.3	-2.7	3.1	-2.8	-3.0	-1.4	-3.1
Blood White Count	0.5	3.9	7.8	-1.2	-1.9	-2.6	-2.8	-0.7	-2.5	1.6	-1.3	-2.4	-1.4	-2.0
Heel T-Score	4.1	32.8	53.3	-3.2	-6.2	-4.9	-6.5	1.4	-7.3	6.4	-4.6	-6.7	-7.2	-5.7
BMI	2.6	15.2	23.8	-3.3	-3.4	-3.6	-4.6	-1.8	-4.8	3.9	-3.1	-4.5	-4.9	-4.0
Height	0.4	7.5	16.3	2.2	1.7	4.0	3.3	1.8	2.9	-3.2	2.0	3.3	2.0	2.7
Waist Hip Ratio (WHR)	0.7	3.2	9.7	1.5	0.3	2.4	1.4	-0.9	2.2	-0.7	3.1	1.7	1.0	2.3
Systolic Blood Pressure	0.0	0.2	0.7	-0.2	0.6	-0.1	0.0	0.1	0.2	-0.8	0.7	0.2	0.1	0.5
Smoking Status	1.3	3.1	7.5	-0.3	-2.4	-0.1	-1.8	2.7	-1.6	2.1	-1.0	-1.8	-2.0	-1.5
Allergy or Eczema	1.4	3.6	7.8	-1.4	-0.4	-1.7	-2.3	0.1	-2.2	2.8	-2.0	-2.2	-1.9	-2.2
Cardiovascular Disease	0.5	1.6	4.3	-0.6	-0.7	-0.6	-2.1	0.6	-1.4	1.8	-1.1	-1.5	-1.2	-1.3
Hypothyroidism (self reported)	1.4	3.3	6.9	-1.4	-1.9	-1.4	-2.1	2.6	-1.9	1.0	-2.0	-1.8	-1.1	-1.8
Respiratory disease	2.7	6.0	14.3	-1.3	-3.8	-2.3	-3.0	1.7	-2.7	1.5	-2.1	-2.3	-2.9	-2.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.3	-0.3	-1.0	0.0	-0.9	-0.8	-1.0	0.1	0.2	-0.6	-1.5	-0.0
Lung FEV1/FVC ratio	0.2	1.1	4.7	1.3	1.8	0.3	0.5	2.2	1.0	0.9	0.1	0.2	0.6	0.0
Lung FVC	0.1	0.8	5.0	0.4	-0.4	0.7	-0.6	2.2	-0.3	0.7	-0.7	-0.6	-0.7	-0.6
Neuroticism	0.4	0.9	3.1	1.8	0.4	1.0	-0.3	1.3	1.1	-0.6	0.5	0.8	-0.4	1.1
Chronotype (morning person)	2.3	5.3	8.9	-2.6	-1.9	-2.1	-1.1	1.8	-2.8	3.0	-1.5	-2.9	-2.3	-2.6
Hair Pigment	0.0	0.6	2.3	-0.2	-1.0	-0.3	-1.0	1.5	-0.8	-0.2	-0.3	-0.8	-0.9	-0.7
Tanning	0.1	1.1	5.7	-0.4	-0.0	-0.7	0.1	2.4	-0.9	1.3	0.1	-0.9	-1.6	-0.3
Hand grip strength (left)	0.2	0.6	2.7	-0.8	0.3	-1.3	-0.3	-0.0	-0.7	-1.6	-0.5	-0.2	0.3	-0.4
Number of treatments/medications taken	2.4	4.3	7.9	-1.6	-2.6	-1.3	-2.8	0.2	-2.6	2.4	-1.2	-2.5	-2.5	-1.7
Average weekly spirits intake	0.2	0.3	1.8	0.2	-1.3	0.3	-0.4	0.7	-0.1	-0.2	0.5	-0.3	-0.4	0.1
Sensitivity / hurt feelings	1.2	2.1	3.6	-0.4	-1.6	-1.9	-1.8	-0.5	-1.6	1.1	-1.6	-1.9	-0.9	-1.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.5	-1.0	-0.7	0.3	-0.9	0.6	-0.4	2.1	-0.7	-1.3	-0.2	-1.1
Hearing difficulty/problems: Yes	0.5	0.8	2.5	1.6	0.4	1.1	0.1	0.6	0.5	0.8	1.0	0.5	-1.3	0.7
Relative age of first facial hair	1.8	3.8	9.4	0.9	1.8	2.5	3.1	0.9	2.0	-1.7	1.0	2.2	2.4	1.6
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.8	2.0	0.1	1.4	0.4	0.4	1.2	-0.6	0.4	1.2	0.5	0.8
Ever used hormone-replacement therapy (HRT)	3.5	4.4	15.1	-0.7	-3.9	-2.2	-2.7	1.2	-2.2	1.4	-1.1	-2.1	-2.3	-1.5
Ever had hysterectomy (womb removed)	3.8	4.3	6.1	-1.9	-2.1	-1.9	-2.2	-1.5	-2.5	2.3	-1.8	-2.5	-1.6	-2.3
Systolic blood pressure, automated reading	0.2	0.6	2.5	-0.7	-0.5	-1.6	-0.7	-1.1	-0.5	0.3	0.5	-0.6	-0.7	0.0
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	10.2	1.3	0.4	2.4	1.1	-0.1	2.0	-0.2	3.2	1.7	-1.8	2.5
Angina	1.5	1.9	3.7	-1.7	-1.9	-0.9	-1.4	-1.1	-1.0	1.7	-1.5	-1.5	-0.5	-1.4
Medication for hormone replacement therapy	2.0	2.3	5.1	-0.9	-2.0	-1.5	-2.2	0.3	-1.8	0.7	-1.3	-1.8	-1.2	-1.6
Vitamin and mineral supplements	0.5	0.6	2.8	-0.0	-0.1	0.8	0.9	1.7	0.4	0.5	1.2	0.3	-0.4	0.6
Supplements: Zinc	0.3	0.3	1.0	-0.8	-0.9	-1.0	-0.3	0.5	0.0	0.0	-0.4	-0.3	-0.8	-0.4
Medication: Co-codamol	0.5	0.5	1.8	-1.0	-0.6	-0.4	-0.9	0.1	-0.5	1.3	-0.5	-1.0	-0.1	-0.6
Medication: Metformin	0.3	0.5	3.7	-0.7	-0.5	-0.2	-0.3	-1.9	-0.3	-0.2	0.5	-0.2	-0.4	0.3
Diabetes (father)	0.3	0.4	1.4	-0.2	-0.5	-0.4	-1.2	-0.5	-0.6	-0.8	-0.8	-0.2	-0.5	-0.6
Diabetes (mother)	0.2	0.3	1.6	1.2	-0.2	-0.4	0.2	-0.6	-0.2	0.2	-0.5	0.2	-0.9	-0.1
Severe depression (siblings)	1.2	1.4	4.2	-1.4	0.8	-0.6	-1.1	-2.1	-0.2	-0.9	-1.7	-0.4	1.4	-0.9
Pack years adult smoking proportion	0.7	1.0	3.4	-0.2	0.3	0.1	0.8	-0.9	1.1	-1.4	1.9	1.0	0.2	1.4
Impedance of leg (right)	0.2	1.0	4.8	0.6	1.5	0.3	1.1	2.2	0.7	-0.2	0.2	0.4	1.3	0.4
Leg fat-free mass (left)	0.1	0.6	3.0	-0.1	-0.6	0.8	-0.4	-1.1	-0.2	-1.7	0.2	0.6	-0.6	0.4
Trunk fat percentage	1.0	3.9	9.1	-1.8	-3.0	-1.4	-2.5	-1.3	-2.2	1.7	-1.2	-2.2	-2.1	-1.7
Hand grip strength (right)	0.3	0.9	3.1	-1.4	0.8	-1.5	0.1	-1.1	-0.2	-1.8	-0.3	0.1	0.7	-0.3
Townsend deprivation index at recruitment	0.1	0.2	0.9	0.3	-0.4	0.4	-0.6	0.2	-0.2	0.9	0.3	-0.3	-0.5	-0.0
Current tobacco smoking	0.3	0.5	3.2	-0.4	-0.2	-0.2	0.2	1.8	0.0	0.9	0.9	-0.4	-0.8	0.2
Average weekly fortified wine intake	1.4	1.7	5.4	2.3	0.7	1.2	0.8	0.5	1.3	-0.9	1.1	1.3	1.7	1.4
Maternal smoking around birth	2.2	3.2	6.1	-1.9	-2.1	-1.5	-2.5	-1.1	-2.0	0.4	-2.3	-1.6	-1.2	-2.0
Fed-up feelings	1.1	2.0	5.8	-0.2	-2.4	-0.1	-2.4	0.8	-1.2	1.1	-1.3	-1.4	-1.5	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.1	-1.1	0.4	0.1	-0.3	1.0	0.4	0.7	-0.1	-0.2	-0.1	-0.2
Relative age voice broke	0.5	0.8	3.0	-0.4	1.2	-0.1	1.5	0.1	1.0	-0.1	-0.5	0.6	1.7	-0.0
Taking other prescription medications	1.3	2.0	4.7	-1.0	-1.9	-0.5	-2.2	0.3	-2.1	0.7	-0.6	-1.6	-1.9	-1.1
Age when periods started (menarche)	0.3	0.6	3.5	-0.1	0.1	1.9	-0.9	-0.1	-0.5	1.0	-0.2	-0.2	-1.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.7	-0.8	-2.2	-0.3	-1.3	0.1	-0.9	0.9	-0.8	-0.9	-0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	8.9	-0.2	-1.6	-0.4	-2.4	0.2	-1.9	1.5	-0.5	-1.3	-3.0	-0.7
Tinnitus: Yes, but not now, but have in the past	1.4	1.4	6.7	1.6	-0.7	2.6	-0.1	0.7	0.4	-0.4	1.6	0.6	-0.6	1.3
Qualifications: CSEs or equivalent	0.7	1.0	3.9	-1.3	-0.3	-1.2	-0.4	-0.7	-0.7	-0.8	-2.0	-0.3	-0.2	-1.3
Serious illness, injury or assault to yourself	0.2	0.3	0.9	-0.5	0.1	0.9	0.3	-0.2	0.7	-0.3	0.3	0.7	0.6	0.7
High blood pressure	0.3	0.8	1.3	-1.1	-0.1	-0.8	-1.1	-0.6	-0.9	1.1	-1.0	-1.1	-0.1	-1.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.5	-0.5	-0.5	-2.0	-2.1	0.6	-1.9	1.7	-1.9	-1.6	-1.7	-1.9
Multivitamins +/- minerals	0.5	0.7	4.5	0.1	0.1	-0.4	-0.5	-2.1	-0.4	-0.6	-1.1	-0.2	0.4	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.4	-0.5	-0.1	0.2	0.0	0.0	-0.0	0.3	-0.4	0.1	-0.6	-0.3
Supplements: Glucosamine	0.2	0.3	1.1	1.0	-0.3	1.0	-0.8	-0.5	-0.2	-0.1	0.1	-0.3	-0.2	-0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	0.6	1.4	0.3	1.5	-0.7	1.1	-1.1	0.8	1.3	1.0	1.2
Medication: Atenolol	1.5	1.9	3.6	-1.3	-0.8	-1.3	-1.5	-0.2	-1.7	1.7	-0.7	-1.9	-1.9	-1.2
Medication: Levothyroxine sodium	0.8	1.4	4.8	-0.6	-2.0	-0.6	-1.0	2.2	-1.1	0.4	-0.5	-1.0	-1.2	-0.6
Sitting height	0.1	0.8	2.9	0.7	0.6	0.9	0.1	1.7	0.2	-1.6	-0.7	0.6	0.6	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	0.1	0.2	0.0	-0.2	0.1	0.2	-0.8	-0.5	0.2	0.0	-0.1
High blood pressure (mother)	0.4	0.6	1.4	0.6	0.9	0.3	0.9	0.8	0.7	-1.0	-0.1	0.8	1.2	0.4
Body mass index (BMI)	1.1	4.6	9.9	-1.3	-2.8	-1.8	-2.8	-1.4	-2.4	2.0	-0.8	-2.3	-3.1	-1.5
Impedance of leg (left)	0.1	0.6	3.9	0.5	0.5	0.2	1.0	2.0	0.4	0.3	0.1	0.0	1.2	0.0
Leg predicted mass (left)	0.1	0.6	3.4	-0.1	-0.6	0.8	-0.4	-1.2	-0.2	-1.9	0.1	0.6	-0.5	0.4
Trunk fat mass	0.6	2.6	5.9	-1.5	-2.4	-0.9	-2.3	-1.4	-1.9	0.9	-0.8	-1.7	-1.9	-1.2
Waist circumference	0.5	1.7	5.1	-0.5	-1.7	-0.2	-1.8	-1.7	-1.3	0.9	0.5	-1.1	-2.3	-0.3
Number of incorrect matches in round	0.4	0.7	3.0	0.2	-0.6	0.4	-1.2	1.7	-0.5	0.6	-0.4	-0.6	-1.0	-0.4
Past tobacco smoking	0.5	1.0	3.1	-1.3	1.8	-1.5	-0.0	-1.6	0.2	0.3	-0.4	-0.2	0.8	-0.5
Alcohol usually taken with meals	0.4	0.7	2.6	-0.1	-0.5	-1.6	-1.0	-0.3	-0.9	0.7	-0.9	-0.9	-0.6	-0.8
Nervous feelings	0.6	1.1	4.7	0.1	-0.9	-0.6	-2.2	-0.3	-0.9	0.2	-1.7	-0.8	-0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	3.9	0.2	-0.3	-0.2	-0.6	2.0	0.4	0.8	-0.3	-0.2	0.1	-0.0
Hearing difficulty/problems with background noise	2.8	4.4	7.6	2.8	1.7	2.0	2.2	0.9	2.7	-1.4	2.5	2.5	0.5	2.5
Hair/balding pattern: Pattern 2	0.2	0.3	1.6	0.8	-0.3	0.4	0.1	0.3	0.0	-1.2	-0.2	0.4	0.3	-0.1
Had menopause	0.8	1.0	3.3	1.8	-0.4	0.6	0.1	0.7	0.7	-0.9	1.5	0.8	0.2	1.4
Had other major operations	1.7	2.1	8.3	-0.4	-0.8	-1.1	-1.5	0.5	-1.4	2.9	0.2	-2.2	-1.6	-1.2
Forced vital capacity (FVC)	0.3	1.3	5.3	-0.2	1.2	0.7	0.0	2.3	0.4	-1.8	-0.9	0.7	1.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	10.0	0.6	-1.5	-0.0	-2.3	0.9	-2.0	1.7	-0.3	-1.5	-3.2	-0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.4	0.6	1.9	1.0	1.3	-0.2	0.8	-1.1	1.0	0.9	0.9	1.1
Qualifications: None of the above	5.0	10.8	21.2	-2.4	-4.6	-2.4	-3.7	0.5	-3.4	4.1	-2.6	-4.2	-2.8	-3.5
Financial difficulties in last 2 years	0.5	0.7	1.7	-0.1	0.3	1.3	0.4	-0.2	1.1	-0.8	0.2	1.1	1.3	0.9
Mouth/teeth dental problems	2.4	3.7	6.2	-2.3	-2.5	-2.3	-1.9	0.4	-2.1	0.7	-2.5	-1.8	-0.6	-2.3
Heart attack	1.1	1.4	3.4	-1.1	-1.1	-0.4	-1.7	0.2	-1.1	1.8	-1.1	-1.5	-1.1	-1.1
Allergy	1.8	4.2	7.7	0.1	2.8	2.0	2.5	-1.8	2.3	-1.6	1.7	1.8	2.7	2.0
Pain all over the body in last month	0.3	0.3	1.2	1.0	-0.7	0.4	-0.4	0.4	-0.2	1.1	0.1	-0.2	-0.5	-0.2
Diabetes (self-reported)	0.6	0.9	2.1	0.8	0.1	1.0	0.6	-1.4	0.7	-1.1	1.1	0.8	0.3	1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.2	-0.2	0.8	-0.0	-0.2	-0.3	0.1	0.4	0.1	0.6	-1.1	0.2
Medication: Ramipril	2.2	2.8	5.5	-1.2	-1.6	-0.8	-1.9	-1.5	-2.3	1.4	-1.5	-2.2	-1.6	-1.7
Medication: Simvastatin	2.3	3.3	7.4	-0.3	-2.6	-0.4	-2.5	1.4	-1.8	2.1	-0.9	-2.0	-2.7	-1.3
Fluid intelligence score	0.5	1.1	2.9	-0.1	1.3	-0.4	0.9	-0.6	1.0	-1.7	1.3	1.2	0.4	1.3
Illnesses of siblings	0.5	0.7	2.2	-0.7	-0.6	0.5	-0.7	1.1	-0.6	-0.3	-1.5	-0.6	0.7	-1.1
Neuroticism score	0.2	0.5	2.4	1.1	-0.3	0.3	-0.9	1.5	0.3	0.0	-0.2	-0.0	-0.7	0.1
Weight	0.2	0.8	2.3	-0.4	-1.4	-0.0	-1.4	-0.9	-1.0	-0.3	-0.2	-0.6	-1.5	-0.3
Impedance of arm (right)	0.1	0.4	1.2	-1.0	0.2	-0.3	0.4	0.8	-0.5	-0.3	-1.1	-0.1	1.0	-0.6
Arm fat percentage (right)	1.6	6.3	11.3	-2.3	-3.0	-2.1	-3.2	-1.3	-3.0	2.3	-1.3	-2.7	-3.4	-2.0
Trunk fat-free mass	0.3	1.5	5.7	1.1	1.0	1.7	0.4	-0.3	0.7	-2.4	1.2	1.5	-0.1	1.3
Hip circumference	0.4	1.8	3.8	-0.9	-1.8	-0.7	-1.8	-1.1	-1.9	0.7	-0.9	-1.2	-2.0	-1.0
Time employed in main current job	1.7	2.0	3.9	-1.6	-2.0	-1.5	-1.2	-0.2	-1.5	1.0	-1.5	-1.6	-0.9	-1.8
Alcohol intake versus 10 years previously	1.0	1.5	3.6	1.9	0.3	1.2	1.2	-0.4	0.8	-1.1	1.7	1.6	-0.7	1.4
Father’s age at death	1.7	2.2	4.6	0.9	1.0	1.0	1.9	-1.3	1.8	-1.1	1.1	1.7	2.1	1.7
Worrier / anxious feelings	0.3	0.5	1.5	0.9	0.4	0.6	0.1	1.2	1.0	-0.5	0.5	0.8	-0.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.5	0.2	-0.1	0.8	-0.3	1.6	0.7	0.2	-0.7	-0.1	0.6	-0.4
Falls in the last year	0.2	0.3	1.3	-0.1	-1.2	0.9	-0.2	-0.5	0.0	0.7	0.1	-0.4	0.1	-0.3
Hair/balding pattern: Pattern 3	0.4	0.6	2.3	-0.2	-1.5	-0.5	-0.6	-0.5	-0.7	1.0	-0.3	-0.6	-1.0	-0.6
Number of live births	3.0	4.2	8.2	-1.0	-1.9	-1.6	-2.7	-1.4	-2.4	2.9	-1.3	-2.6	-2.0	-1.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.2	0.1	1.4	0.9	0.1	2.3	0.7	-1.4	-0.9	0.6	1.3	-0.2
Pulse rate	2.2	3.7	8.8	1.1	0.7	1.4	1.9	0.1	2.3	-3.0	2.0	2.6	1.5	2.4
Happiness	1.4	1.7	6.5	-1.0	-0.1	-0.3	-1.9	-0.8	-1.0	2.6	-1.0	-1.6	-0.9	-1.2
Noisy workplace	0.2	0.2	0.6	-0.2	0.5	-0.6	0.5	0.6	-0.6	-0.8	0.1	-0.3	-0.4	0.1
Qualifications: A levels/AS levels or equivalent	1.6	3.6	7.5	1.7	2.7	1.2	1.7	-0.5	1.7	-2.7	1.3	2.5	1.6	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.5	-0.3	0.8	0.7	-0.2	-1.2	-0.4	0.8	-0.4	-0.4	-0.9	-0.3
Mouth/teeth dental problems: Dentures	1.6	2.7	7.9	1.2	2.1	1.4	1.8	0.2	1.9	-0.3	2.8	1.6	-0.2	2.2
Asthma	4.3	8.4	13.7	-1.8	-3.7	-2.5	-3.3	1.1	-3.4	2.7	-2.5	-3.3	-3.2	-3.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.9	-0.5	0.4	-0.7	-1.1	1.5	-0.9	1.0	-0.3	-0.8	-2.0	-0.4
Medication: Cholesterol lowering	0.6	1.0	2.4	-1.5	-1.1	-0.4	-1.6	-0.6	-0.8	0.6	-1.0	-1.2	-0.3	-0.9
Depression (self-reported)	0.3	0.4	0.8	-0.7	-0.4	-0.3	-0.8	0.2	-0.4	0.4	-0.9	-0.5	-0.8	-0.6
Medication: Lansoprazole	0.6	0.7	2.2	0.5	-1.0	0.9	-1.5	-0.7	-0.9	0.7	-0.1	-0.5	-1.0	-0.3
Prospective memory result	0.9	1.1	4.5	-0.8	0.7	-0.2	1.2	-1.3	0.7	-1.3	-0.4	0.6	2.1	0.0
Lung cancer (father)	0.1	0.2	0.6	0.6	0.4	0.0	0.8	0.4	-0.1	-0.7	0.1	0.0	0.4	-0.0
Illnesses of mother	0.5	0.6	1.6	-1.2	-0.3	0.4	-0.5	0.4	-0.5	1.0	0.9	-0.7	-1.3	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.8	0.1	2.2	1.1	0.4	1.0	1.0	-1.7	-1.1	0.9	2.0	-0.2
Pulse wave Arterial Stiffness index	1.3	1.5	5.3	1.6	-0.1	1.8	0.5	0.1	0.9	-0.2	2.3	1.1	-0.5	1.8
Impedance of arm (left)	0.1	0.4	1.3	-0.9	-0.2	-0.1	0.5	0.6	-0.2	-0.0	-0.9	-0.1	1.1	-0.5
Arm fat mass (right)	0.9	3.6	8.1	-1.5	-2.4	-1.2	-2.6	-1.4	-2.3	1.3	-0.8	-1.9	-2.9	-1.4
Trunk predicted mass	0.2	1.4	5.1	1.1	0.8	1.6	0.3	-0.3	0.6	-2.3	1.1	1.4	-0.2	1.3
Standing height	0.7	7.2	19.9	1.8	2.3	3.4	2.5	1.1	2.5	-4.5	1.2	3.2	2.9	2.3
Length of working week for main job	1.8	2.0	5.8	2.4	0.3	1.1	1.0	2.4	0.9	0.7	1.7	1.3	-0.8	1.3
Exposure to tobacco smoke at home	0.9	1.0	4.2	1.0	0.8	2.0	1.0	-0.6	1.2	1.1	0.4	0.6	0.8	0.5
Breastfed as a baby	1.0	1.2	3.1	0.9	1.4	1.4	0.7	-0.2	1.2	-0.8	1.8	1.0	-0.0	1.5
Tense / ‘highly strung’	0.1	0.1	0.3	0.1	0.1	0.2	-0.5	-0.5	0.2	-0.2	-0.3	0.4	-0.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.5	6.1	-0.2	-1.0	0.6	-1.7	1.5	-0.9	1.0	-0.6	-0.8	-2.5	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.8	0.1	1.3	0.1	0.2	1.0	0.6	1.2	0.6	0.2	-0.7	0.6
Birth weight of first child	0.0	0.1	0.4	-0.2	-0.2	0.1	-0.2	-0.6	-0.3	0.2	-0.5	-0.1	0.3	-0.2
Peak expiratory flow (PEF)	0.3	0.7	3.6	0.1	0.2	0.3	-0.4	1.4	0.8	-0.8	-0.9	0.4	1.9	-0.2
Pulse wave reflection index	0.6	0.7	1.9	1.1	0.1	1.2	0.4	1.0	0.5	0.7	1.4	0.4	-0.5	0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.1	0.6	-0.2	1.1	-0.6	0.3	-0.3	1.8	0.2	-0.3	-1.3	0.0
Loud music exposure frequency	0.3	0.4	1.4	0.9	-0.0	1.2	0.5	0.3	0.1	-0.9	0.3	0.5	-0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.2	1.1	1.8	0.8	0.9	-0.0	0.4	-1.2	1.0	0.9	0.4	1.1
Mouth/teeth dental problems: Bleeding gums	2.3	3.0	4.3	1.9	1.4	1.5	2.1	-1.1	1.5	-1.9	2.0	1.8	1.5	2.1
Blood clot in the leg (DVT)	0.3	0.4	2.4	-0.1	-1.6	0.4	0.8	0.2	-0.1	-0.2	0.3	0.5	-0.5	0.1
Medication: Paracetamol	0.3	0.5	2.1	0.3	-0.0	-0.3	-0.6	0.8	-0.0	1.4	0.4	-0.3	-1.2	0.0
Headache pain in last month	1.9	3.2	6.4	-0.6	-1.9	-0.7	-2.5	2.0	-2.2	1.7	-1.2	-2.1	-2.2	-1.6
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.6	2.1	1.4	0.6	1.8	1.0	1.3	-1.1	1.3	1.7	0.5	1.4
Glaucoma (self-reported)	0.7	0.8	3.3	0.4	-0.2	-0.6	0.4	-1.3	0.7	-1.8	0.4	1.0	1.1	0.8
Gout (self-reported)	0.1	0.1	0.5	0.4	-0.1	-0.1	-0.0	-0.4	0.3	-0.7	0.2	0.4	-0.2	0.3
Hypothyroidism/myxoedema (self-reported)	2.0	4.0	7.5	-1.7	-2.7	-2.0	-2.0	2.0	-2.3	1.2	-1.7	-2.3	-1.7	-2.0
Medication: Amlodipine	0.6	0.8	2.6	-0.6	0.1	0.1	-0.6	-0.9	-0.9	1.6	0.1	-1.1	-1.6	-0.6
Medication: Ventolin 100micrograms inhaler	2.0	2.6	5.5	-1.3	-2.3	-2.2	-1.6	-0.2	-1.7	1.1	-1.3	-1.8	-1.5	-1.7
Birth weight	0.8	1.8	3.9	1.0	1.9	0.8	1.8	-0.3	1.2	-1.1	1.2	1.2	2.0	1.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	2.2	0.0	0.4	0.5	-0.1	-1.5	0.2	-0.8	-0.3	0.3	0.7	0.0
High blood pressure (siblings)	1.9	2.7	6.8	0.5	1.9	-0.1	2.1	-2.6	1.7	-1.1	1.7	1.5	1.8	1.7
Forced vital capacity (FVC), Best measure	0.3	1.1	2.8	0.0	1.6	1.1	0.2	1.2	0.6	-1.7	-1.0	0.8	1.5	-0.2
Body fat percentage	1.0	4.0	7.7	-1.8	-2.8	-1.5	-2.6	-1.3	-2.3	1.9	-0.9	-2.3	-2.3	-1.6
Leg fat percentage (right)	0.6	2.1	3.9	-1.2	-1.6	-1.2	-2.0	-1.1	-1.4	1.6	-0.1	-1.8	-1.9	-0.8
Arm fat-free mass (right)	0.2	1.2	3.6	1.5	-0.0	1.5	0.1	-0.4	0.6	-1.9	1.2	1.2	-0.4	1.1
Exposure to tobacco smoke outside home	0.5	0.7	2.5	0.4	-1.0	1.1	0.1	1.6	0.2	0.2	1.1	0.4	-0.9	0.8
Comparative body size at age 10	0.8	2.1	4.2	-1.3	-0.6	-1.6	-1.4	0.7	-1.6	1.3	-2.0	-2.0	-0.2	-2.1
Number of full brothers	0.3	0.4	1.0	0.9	-0.5	0.5	0.1	0.3	0.3	0.3	1.0	0.4	-0.9	0.9
Worry too long after embarrassment	1.0	1.6	5.0	2.2	0.7	0.2	0.6	1.4	1.5	-1.2	1.3	1.4	-0.0	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	-0.6	0.2	0.6	0.1	0.9	0.4	0.5	0.7	0.3	-1.1	0.5
Wheeze or whistling in the chest in last year	1.3	2.3	9.7	-0.3	-3.1	0.7	-1.4	1.0	-1.5	1.9	-0.4	-1.4	-1.9	-1.0
Number of children fathered	1.4	1.6	4.6	-0.2	-1.0	-0.9	-0.6	1.1	-1.4	2.1	-1.0	-1.5	-1.4	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.9	1.2	1.0	1.3	1.1	-0.6	1.3	-1.6	1.1	1.7	1.3	1.5
Age at first live birth	1.1	2.0	6.8	-0.1	1.8	2.2	0.7	0.2	1.3	-2.0	-0.5	1.0	2.6	0.3
Pulse wave peak to peak time	1.0	1.2	4.4	-1.3	0.1	-1.6	-0.4	0.3	-0.7	0.1	-2.1	-0.9	0.6	-1.6
Health satisfaction	1.5	1.9	5.4	-0.5	-1.2	-0.0	-2.3	1.4	-1.2	1.7	-1.2	-1.6	-1.4	-1.4
Shortness of breath walking on level ground	1.1	1.3	6.5	0.7	-1.1	-0.1	-1.4	1.1	-0.6	1.3	0.7	-0.6	-2.6	-0.1
Qualifications: College or University degree	2.5	8.0	21.0	2.3	4.6	2.3	2.8	-0.4	2.8	-3.1	2.0	3.4	2.8	2.7
Eye problems/disorders: None of the above	2.9	3.4	6.0	-1.6	-1.2	-2.0	-1.9	0.7	-2.4	1.6	-2.4	-2.3	-1.1	-2.1
Mouth/teeth dental problems: Loose teeth	3.0	3.5	7.2	1.5	1.4	2.0	1.5	-0.4	2.6	-1.4	2.5	2.3	0.7	2.7
Emphysema/chronic bronchitis	1.1	1.3	3.3	1.6	-1.2	0.8	-0.1	1.8	1.2	-0.8	1.4	0.8	-0.3	1.1
Medication for pain relief, constipation, heartburn	1.7	3.0	10.1	1.1	1.0	0.6	1.8	-1.6	1.3	-2.9	-0.7	1.7	3.2	0.6
Neck or shoulder pain in last month	0.8	1.1	2.7	-0.4	-1.2	-0.5	-0.9	1.6	-0.8	1.5	-1.1	-0.8	-1.0	-0.9
Medication: Blood pressure	1.1	2.0	4.1	-2.0	-2.0	-0.5	-1.4	-0.7	-1.6	1.5	-0.9	-1.8	-0.7	-1.4
Angina (self-reported)	1.0	1.3	2.8	-1.3	-1.6	-0.7	-1.2	-1.0	-0.6	1.7	-1.2	-1.2	-0.4	-1.1
Migraine (self-reported)	1.7	2.1	4.4	-1.9	-0.9	-1.3	-1.3	-0.5	-1.6	2.1	-1.0	-1.8	-0.9	-1.8
Medication: Ibuprofen	0.6	0.8	3.8	0.3	0.0	-0.1	-0.8	2.0	-0.3	0.8	0.1	-0.2	-1.8	0.2
Medication: Allopurinol	0.1	0.2	0.7	0.8	-0.7	0.4	-0.1	0.0	0.2	-0.3	0.4	0.1	-0.3	0.4
Medication: Omeprazole	1.3	1.5	5.1	-0.6	-2.3	0.6	-0.5	-0.5	-1.7	1.6	-0.0	-1.2	-1.8	-0.7
Medication: Seretide 50 evohaler	0.2	0.2	1.8	0.2	-0.2	-0.0	0.4	-1.4	0.3	-0.4	0.1	0.3	0.3	0.1
Mean time to correctly identify matches	5.1	9.7	15.1	3.6	3.5	3.5	3.2	0.1	3.3	-2.2	3.8	3.5	1.3	3.9
Heart disease (mother)	0.3	0.3	1.4	0.4	0.9	-1.2	-0.2	0.3	0.3	-0.2	0.5	0.3	-0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	2.1	-0.6	-0.1	-0.6	-0.3	-1.1	-0.5	-1.4	0.2	0.0	0.5	0.2
Whole body fat mass	0.8	3.2	6.4	-1.6	-2.3	-1.1	-2.5	-1.7	-2.1	1.0	-0.8	-1.8	-2.3	-1.3
Leg fat mass (right)	0.5	1.9	4.5	-1.3	-1.8	-0.8	-1.9	-1.4	-1.5	0.9	-0.0	-1.4	-2.1	-0.7
Arm predicted mass (right)	0.3	1.6	4.2	1.7	0.1	1.8	0.5	-0.3	0.9	-2.0	1.6	1.4	-0.3	1.5
Pulse rate, automated reading	1.5	4.9	11.8	1.6	1.6	0.6	2.0	-0.8	2.2	-3.4	2.7	2.7	1.8	2.9
Alcohol intake frequency.	3.6	8.4	12.5	-2.3	-3.1	-2.4	-3.0	-1.0	-3.4	3.2	-2.7	-3.5	-3.0	-3.3
Comparative height size at age 10	0.2	1.2	3.2	1.1	-0.3	1.8	0.6	0.0	1.0	-1.8	0.0	1.3	1.5	0.7
Number of full sisters	0.3	0.3	1.6	-0.0	1.0	-0.5	0.1	0.1	-0.4	0.5	0.3	0.0	-1.3	0.1
Suffer from ‘nerves’	0.4	0.6	2.4	0.8	-0.1	0.5	-1.0	1.5	0.7	-0.9	-0.2	0.7	-0.2	0.4
Overall health rating	0.6	1.3	4.2	-0.5	-2.1	-0.0	-1.3	-0.3	-1.1	0.5	-1.3	-1.2	-1.2	-1.4
Chest pain or discomfort	1.9	2.8	5.2	2.3	-0.1	2.2	1.5	1.6	2.0	-0.8	1.8	1.8	-0.3	2.1
Had major operations	0.3	0.4	1.5	-0.5	-0.5	0.0	-0.2	-1.2	-0.2	1.0	-0.6	-0.4	-0.3	-0.7
Age at last live birth	0.6	0.9	3.0	0.3	1.2	1.5	-0.1	-0.8	0.7	-0.9	-1.0	0.4	1.7	-0.3
Family relationship satisfaction	0.4	0.5	2.4	-0.0	0.9	1.5	-0.1	0.4	0.9	0.6	-0.6	0.6	0.5	0.0
Leg pain on walking	0.9	1.1	4.2	1.8	0.5	1.6	0.4	2.0	0.4	0.4	0.9	0.4	-0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.2	1.1	0.1	1.1	0.9	-0.0	1.0	-0.8	1.3	1.2	-0.1	1.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.1	1.0	-0.9	0.8	0.8	1.3	0.8	-0.2	1.4	1.2	-0.6	1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.0	1.4	-0.0	0.1	0.8	1.2	0.4	-0.7	0.3	0.7	0.4	0.4
Medication: Aspirin	0.8	1.1	3.1	-1.4	-1.0	-0.4	-1.8	-0.7	-0.9	1.0	-0.8	-1.2	-0.5	-1.1
Supplements: Vitamin C	1.2	1.4	4.8	1.4	0.8	0.8	0.8	0.5	1.0	-2.2	0.9	1.7	0.4	1.4
Knee pain experienced in last month	0.5	0.7	2.4	1.5	-1.0	0.7	0.5	1.4	0.1	0.2	0.8	0.1	-0.8	0.7
Hypertension (Self-reported)	0.3	1.0	1.5	-1.2	-0.1	-1.0	-1.1	-0.8	-1.0	1.2	-1.0	-1.2	-0.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.2	1.1	-0.5	1.5	0.2	0.0	-0.1	0.4	0.8	0.5	-1.1	0.7
Illnesses of father: Heart disease	0.3	0.4	1.3	1.0	1.0	-0.2	-1.1	0.6	0.3	-0.3	-0.3	0.5	-0.3	0.3
Illnesses of siblings: Diabetes	0.7	0.9	3.2	0.6	0.3	-0.1	-0.2	-1.2	0.1	-0.2	1.3	0.9	-1.8	1.3
Smoking status: Previous	0.6	0.9	4.8	1.1	-2.2	1.2	-0.7	0.7	-0.7	-0.1	-0.4	-0.2	-0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.0	-0.0	0.4	0.4	0.2	0.5	0.5	-0.8	0.0	0.3	1.0	0.2
Whole body fat-free mass	0.1	0.9	4.1	0.7	-0.0	1.4	0.0	-0.6	0.2	-2.0	0.8	1.0	-0.5	0.9
Leg fat-free mass (right)	0.1	0.6	2.6	-0.1	-1.0	0.7	-0.4	-1.3	-0.3	-1.6	0.1	0.5	-0.6	0.2
Arm fat percentage (left)	1.6	6.3	10.6	-2.3	-3.2	-2.0	-3.3	-1.6	-2.9	2.3	-1.3	-2.8	-3.1	-2.0
Average weekly red wine intake	0.9	1.4	5.0	0.2	1.4	0.7	0.7	-2.2	1.1	-1.3	0.1	1.2	1.5	1.0
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.8	-0.5	-1.6	-1.3	-1.2	0.8	-1.7	1.8	-1.0	-1.4	-2.2	-1.4
Mood swings	1.8	3.2	5.9	-0.8	-1.7	-1.1	-1.9	2.3	-1.3	2.4	-1.7	-2.0	-1.8	-1.9
Loneliness, isolation	0.2	0.3	1.3	-1.1	1.0	-0.2	-0.1	-0.0	0.2	0.1	-0.2	-0.2	0.6	-0.2
Long-standing illness, disability or infirmity	0.3	0.4	0.9	0.5	-0.8	-0.5	-0.9	-0.3	-0.4	-0.0	-0.9	-0.7	0.5	-0.7
Ever had bowel cancer screening	0.1	0.2	0.6	0.1	0.3	0.3	0.2	0.3	0.4	0.3	0.8	0.3	-0.1	0.6
Diabetes diagnosed by doctor	0.5	0.8	1.9	0.9	0.5	0.9	0.6	-1.2	0.7	-0.7	1.4	0.8	-0.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	-0.1	0.6	-0.1	0.9	-0.2	1.0	-0.4	-0.1	0.7	1.0	0.4
Friendships satisfaction	1.2	1.4	4.3	-1.1	1.8	0.3	-0.8	-1.9	0.4	0.1	-1.5	0.3	2.1	-0.5
Qualifications: nursing, teaching	2.8	4.4	7.5	1.5	2.6	1.5	2.0	-0.0	2.5	-2.7	1.8	2.7	1.8	2.3
Commuting to job workplace: Walk	1.4	1.5	7.9	-0.9	-0.5	-2.8	-1.5	0.0	-0.8	0.2	-1.4	-1.1	-0.3	-1.2
Eye problems/disorders: Cataract	0.3	0.3	1.2	0.3	0.2	1.1	0.5	-0.4	0.6	-0.5	0.7	0.4	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	5.9	0.6	-1.5	0.4	-1.3	0.9	-1.5	2.0	-0.7	-1.5	-2.4	-1.1
Medication for cholesterol	2.5	3.8	7.8	1.4	1.8	2.0	2.8	1.7	2.2	-1.6	1.8	2.3	1.3	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	8.6	1.3	0.3	1.3	1.6	1.6	1.4	-0.7	2.9	1.2	-0.2	2.3
Back pain experienced in last month	1.4	2.1	6.7	0.2	-2.0	0.6	-0.8	2.6	-1.4	1.1	-0.3	-1.0	-2.6	-0.7
Mineral and other dietary supplements	0.8	1.1	3.5	0.8	0.8	0.8	1.9	-0.4	1.3	-0.1	1.1	1.3	0.5	1.1
Breast cancer (self-reported)	4.6	5.5	8.0	1.6	2.8	2.2	2.7	0.0	2.5	-2.6	2.1	2.7	2.6	2.4
Asthma (self-reported)	4.4	8.8	16.4	-1.7	-4.0	-2.6	-3.6	1.3	-3.5	2.6	-2.5	-3.4	-3.2	-3.2
Osteoporosis (self-reported)	0.3	0.3	0.7	0.5	-0.0	0.7	0.6	-0.4	0.5	-0.8	0.2	0.8	0.8	0.3
Osteoarthritis (self-reported)	0.6	0.8	2.8	0.4	-1.7	0.9	-0.2	1.6	-0.1	1.2	0.1	-0.3	-1.2	-0.1
Medication: Aspirin	0.8	1.1	3.5	-1.1	-1.4	-0.0	-1.9	-0.5	-0.9	1.0	-0.8	-1.2	-0.6	-1.0
Medication: Gliclazide	0.3	0.4	1.0	-0.6	0.3	-0.5	-0.7	-0.9	-0.1	-0.2	0.9	-0.0	-1.0	0.7
Illnesses of father: None of the above (group 1)	0.6	0.8	3.0	0.3	-1.1	-0.4	1.6	0.3	0.2	0.5	1.7	0.1	-0.6	0.8
Smoking status: Current	0.3	0.4	2.6	-0.4	0.1	-0.2	0.2	1.6	-0.1	0.9	0.6	-0.5	-0.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.0	-0.2	1.6	-0.2	0.3	-0.4	1.1	-0.5	-0.7	0.4	2.0	0.0
Whole body water mass	0.2	0.9	4.2	0.8	0.1	1.3	0.0	-0.5	0.2	-2.0	0.8	1.1	-0.5	0.9
Leg predicted mass (right)	0.1	0.6	2.7	-0.0	-0.9	0.8	-0.3	-1.2	-0.2	-1.6	0.2	0.6	-0.5	0.3
Arm fat mass (left)	1.0	4.0	7.7	-1.7	-2.6	-1.3	-2.7	-1.6	-2.4	1.5	-0.9	-2.0	-2.8	-1.5
Number of self-reported non-cancer illnesses	3.7	6.4	13.9	-1.6	-3.7	-2.1	-2.8	0.6	-2.7	3.0	-1.7	-2.6	-3.2	-2.3
Average weekly champagne plus white wine intake	2.1	2.8	5.5	1.1	2.3	1.9	1.5	-1.1	2.0	-1.1	1.9	2.0	0.5	2.1
Miserableness	0.9	1.6	4.5	-0.1	-1.2	0.6	-1.6	1.7	-0.8	1.0	-1.1	-1.2	-2.1	-1.0
Guilty feelings	0.9	1.4	2.8	1.7	1.7	1.3	0.8	1.6	1.4	0.1	1.2	0.5	0.4	1.1
Wears glasses or contact lenses	0.7	0.8	2.7	0.9	-0.1	0.1	-1.4	0.9	-0.2	1.0	0.9	-0.1	-1.7	0.6
Ever taken oral contraceptive pill	0.2	0.3	0.7	0.5	-0.3	0.7	-0.5	-0.2	-0.3	-0.5	-0.8	-0.1	0.6	-0.7
Hearing aid user	0.3	0.3	0.8	-0.3	0.6	0.2	-0.2	-0.8	-0.6	0.9	-0.0	-0.6	-0.9	-0.3
Mother’s age at death	0.6	0.7	3.6	-0.2	0.0	0.1	0.7	-1.6	0.8	-0.5	0.0	0.4	1.9	0.3
Financial situation satisfaction	2.3	2.8	6.7	-1.3	-1.6	0.2	-2.0	1.5	-1.7	2.1	-1.1	-1.8	-2.6	-1.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	-1.2	-0.1	-0.9	-1.4	-0.2	-0.9	0.1	-1.3	-0.7	-0.4	-1.0
Commuting to job workplace: Public transport	2.2	2.6	6.0	1.2	2.5	1.5	1.4	-0.7	2.0	-1.0	1.8	1.7	1.4	1.9
Eye problems/disorders: Glaucoma	0.2	0.3	1.1	-0.3	0.2	-0.8	-0.5	-1.0	0.0	-0.8	-0.1	0.1	0.7	-0.0
Medication: Blood pressure	0.3	0.6	1.2	-0.5	-0.4	-1.1	-1.1	-1.0	-0.9	0.5	-0.5	-0.8	-0.7	-0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.6	5.5	0.5	-1.9	1.1	-0.7	1.6	-0.5	1.7	0.5	-0.7	-2.4	-0.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	-1.4	-0.5	-1.1	-1.5	0.8	-1.0	0.4	-0.9	-1.1	-0.3	-0.9
High cholesterol (Self-reported)	0.2	0.3	1.0	0.5	-0.8	-0.3	-0.4	0.3	0.2	0.3	0.7	-0.1	-1.0	0.4
Medication: Bendroflumethiazide	1.8	2.8	4.7	-0.9	-1.1	-2.1	-1.7	-1.9	-2.1	1.9	-0.5	-1.8	-2.2	-1.3
Medication: Paracetamol	0.5	0.8	3.5	0.6	-0.0	-0.2	-0.7	0.9	-0.2	1.7	0.5	-0.3	-1.9	0.1
Medication: Lisinopril	0.1	0.2	0.8	-0.4	-0.2	0.9	-0.2	0.3	0.5	0.4	0.1	-0.1	0.5	-0.2
Medication: Atorvastatin	0.2	0.2	1.0	0.3	0.2	0.1	0.2	-0.4	0.2	-0.3	1.0	0.4	-0.3	0.7
Illnesses of father: High blood pressure	0.3	0.3	0.7	-0.4	0.5	0.4	-0.5	-0.8	0.2	-0.8	-0.8	0.4	0.6	-0.2
Alcohol drinker status: Never	0.6	0.8	2.9	0.4	-0.0	0.0	-1.2	1.5	-0.4	0.6	0.2	-0.9	-1.7	-0.4
Ever smoked	1.4	2.4	7.3	2.1	-0.4	2.4	1.3	2.7	1.0	-0.6	1.7	1.1	-0.2	1.5
Basal metabolic rate	0.1	0.6	2.7	0.4	-0.4	1.0	-0.4	-0.7	-0.2	-1.6	0.4	0.6	-0.8	0.5
Leg fat percentage (left)	0.7	2.6	4.9	-1.3	-2.2	-1.3	-2.0	-1.4	-1.6	1.8	-0.2	-2.0	-2.0	-1.0
Arm fat-free mass (left)	0.1	0.7	2.6	1.1	-0.2	1.2	-0.0	-0.2	0.2	-1.6	0.9	0.9	-0.6	0.8
Number of operations (self-reported)	0.7	1.1	6.7	0.7	-0.3	0.2	0.0	-0.6	-0.1	2.6	0.8	-0.6	-1.7	0.1
Average weekly beer plus cider intake	0.7	1.1	2.6	-1.5	0.4	-1.5	-0.5	-0.0	-0.3	0.0	-1.6	-0.7	1.3	-1.4
Irritability	0.4	0.7	2.9	1.7	-1.2	0.9	0.3	1.1	0.5	0.2	0.1	0.5	-0.6	0.5
Risk taking	1.4	2.1	3.9	1.4	1.8	1.1	1.4	-1.0	1.6	-0.3	2.0	1.7	0.6	1.9
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.3	0.4	1.8	1.1	1.3	-1.2	1.8	-0.7	0.9	1.7	1.3	1.3
Fractured/broken bones in last 5 years	0.4	0.5	2.2	0.0	-0.8	-0.7	-0.4	-0.7	0.2	0.7	0.9	0.1	-1.5	0.5
Age started oral contraceptive pill	0.6	0.8	6.9	0.4	-1.1	-0.1	-0.1	-2.6	-0.5	0.4	-0.1	0.1	0.2	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	2.0	-0.3	-0.1	-1.4	-0.9	-1.1	0.2	-0.5	-0.1	-0.0	0.5	0.3
Ever depressed for a whole week	0.6	0.7	1.9	0.6	1.0	0.7	1.1	0.2	0.8	-0.0	1.4	0.9	-0.4	1.2
Unable to work because of sickness or disability	0.2	0.2	1.3	-0.2	0.2	-0.1	-0.3	-0.4	0.2	0.5	-0.6	-0.4	1.1	-0.3
Commuting to job workplace: Cycle	1.7	2.0	3.8	1.4	1.9	1.1	0.8	-0.5	1.6	-2.0	0.3	1.9	1.8	1.1
Myopia	0.4	0.6	2.3	0.7	0.8	1.5	-0.2	-1.1	0.2	0.0	0.6	0.4	-0.7	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.1	1.4	0.4	1.0	1.4	0.9	1.0	-1.3	1.4	1.4	0.2	1.3
Cholesterol lowering medication	0.8	1.2	4.4	0.0	-1.4	-1.1	-1.6	-0.3	-1.0	1.2	-0.0	-0.9	-2.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	6.3	-0.4	-1.5	0.6	-1.1	0.3	-1.8	2.4	0.1	-1.3	-2.5	-0.8
Pain experienced in last month	3.1	5.2	10.8	0.1	2.5	0.1	2.2	-2.9	2.7	-2.6	1.7	2.3	3.3	2.0
Supplements: Calcium	0.6	0.7	2.2	0.6	-0.7	-0.1	0.2	1.5	0.8	-1.1	0.9	0.7	0.4	0.9
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	1.0	0.1	0.9	0.1	0.7	0.8	-0.4	0.2	0.7	0.5	0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.6	-1.1	-1.1	-0.6	-1.6	-0.2	-1.1	1.9	-1.0	-1.4	-1.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	0.2	-1.4	0.7	1.0	0.0	0.2	-0.4	0.7	0.7	-0.2	0.5
Heart disease (siblings)	0.5	0.6	2.4	0.5	-0.3	-0.1	-0.6	1.2	-0.1	0.7	0.9	-0.1	-1.5	0.4
Alcohol drinker status: Previous	0.8	0.9	1.7	-1.1	-0.7	-0.7	-0.9	-0.5	-1.2	1.2	-0.3	-1.1	-1.3	-0.9
Pack years of smoking	0.9	1.3	4.0	-0.3	0.4	-0.1	1.1	-1.0	1.3	-1.5	2.0	1.2	0.3	1.5
Impedance of whole body	0.1	0.5	2.5	0.0	0.1	0.1	0.8	1.6	0.1	0.2	-0.5	0.1	1.2	-0.3
Leg fat mass (left)	0.6	2.4	5.0	-1.4	-2.2	-1.0	-2.0	-1.6	-1.7	1.1	-0.2	-1.7	-2.1	-0.9
Arm predicted mass (left)	0.2	0.9	2.9	1.3	-0.2	1.2	0.0	-0.4	0.3	-1.7	1.1	1.0	-0.8	0.9