TWAS hub - MAN2A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1310	0.0310	4.9e-12	0.088	0.119	0.131	0.130	0.141	7.2e-11	2.5e-14	1.2e-15	1.7e-15	9.3e-17
2	GTEx	Artery Aorta	0.1050	0.0450	5.9e-03	0.033	NA	0.022	NA	0.012	6.3e-03	NA	2.1e-02	NA	6.6e-02
3	GTEx	Nerve Tibial	0.0689	0.0282	2.0e-03	0.012	NA	0.000	NA	0.013	4.1e-02	NA	3.2e-01	NA	3.7e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.0742	0.0262	1.6e-04	0.013	0.040	0.006	0.032	0.006	7.3e-03	6.4e-06	4.4e-02	5.5e-05	4.5e-02
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0747	0.0390	4.8e-03	-0.002	0.015	0.003	NA	-0.002	8.2e-01	8.0e-03	1.4e-01	NA	5.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Qualifications: None of the above	4.3	9.2	19.6	-4.4	0.9	3.6	-3.0	1.9
Schizophrenia (2018)	3.9	8.2	15.2	3.9	-2.3	-3.8	2.4	-0.4
Ever used hormone-replacement therapy (HRT)	3.8	4.9	9.1	-2.7	2.1	3.0	-1.8	-0.1
Qualifications: College or University degree	3.8	12.1	33.3	5.8	1.0	-2.8	3.8	-2.0
Asthma (self-reported)	3.6	7.1	15.1	-3.9	1.4	3.8	-1.8	1.0
Schizophrenia (2014)	3.3	7.2	14.4	3.5	-1.9	-3.8	2.1	-1.1
Father’s age at death	3.3	4.5	12.6	1.9	-3.6	-1.2	2.2	0.2
Back pain experienced in last month	3.3	4.8	9.4	-3.1	1.9	2.4	-1.5	1.7
Wheeze or whistling in the chest in last year	3.2	5.7	10.6	-3.0	1.8	1.4	-1.9	3.2
Pain experienced in last month	3.2	5.3	7.7	2.5	-2.8	-2.8	1.9	-1.1
Reaction Time	3.1	5.8	13.2	1.7	-1.0	-3.6	2.8	2.0
Ever had hysterectomy (womb removed)	3.1	3.6	8.1	-2.0	0.1	2.8	-2.0	-1.3
Asthma	3.1	6.1	13.8	-3.6	0.9	3.7	-1.5	0.8
Bipolar Disorder or Schizophrenia	3.0	7.3	14.4	3.8	-2.1	-3.5	2.2	-0.7
Respiratory disease	3.0	6.7	15.4	-3.9	1.3	3.1	-2.0	1.6
Financial difficulties in last 2 years	2.9	3.9	8.5	-0.3	-1.5	-2.9	0.1	2.9
Mouth/teeth dental problems: Loose teeth	2.8	3.3	12.2	1.8	-0.1	-3.5	1.0	0.3
Intelligence (Savage-Jansen 2018)	2.7	8.4	22.4	4.7	0.3	-1.5	2.9	-3.0
Smoking status: Previous	2.7	4.1	10.3	-1.7	1.0	1.6	-1.9	3.2
Medication for hormone replacement therapy	2.6	2.9	4.8	-2.0	1.8	1.5	-2.2	0.7
Past tobacco smoking	2.6	4.8	11.7	2.2	-1.2	-0.7	2.3	-3.4
Commuting to job workplace: Car/motor vehicle	2.6	3.0	4.8	-2.2	1.7	0.9	-2.0	1.5
Taking other prescription medications	2.5	3.9	7.4	-2.7	1.8	1.1	-1.4	2.4
Medication: Ventolin 100micrograms inhaler	2.5	3.3	9.0	-3.0	-0.1	2.5	-0.4	0.8
Mean time to correctly identify matches	2.4	4.6	9.3	1.5	-1.6	-2.7	3.0	1.3
Average weekly red wine intake	2.4	3.6	8.2	2.9	-1.1	-1.7	1.5	-1.8
Medication: Bendroflumethiazide	2.4	3.7	9.4	0.9	0.5	2.8	0.1	-3.1
Smoking Status	2.3	5.6	11.5	-3.4	1.7	1.6	-2.6	2.1
Commuting to job workplace: Walk	2.3	2.5	4.7	-0.2	1.9	-0.4	-2.0	-2.2
Angina	2.2	2.9	5.0	-1.8	-2.2	0.3	-1.4	2.1
Qualifications: A levels/AS levels or equivalent	2.2	4.8	14.9	3.9	0.3	-2.8	1.2	0.2
Hypothyroidism/myxoedema (self-reported)	2.2	4.2	9.1	-3.0	0.4	2.0	-2.4	1.5
Commuting to job workplace: Cycle	2.2	2.6	6.1	2.1	0.1	-1.3	2.5	-0.8
Ever smoked	2.1	3.7	10.8	-1.7	1.6	-0.5	-1.5	3.3
Risk taking	2.1	3.1	5.9	2.4	1.6	-1.2	1.7	-1.5
Supplements: Calcium	2.1	2.3	4.9	-1.5	2.0	0.5	-2.2	-0.3
Verbal and Numeric Reasoning (VNR)	2.0	4.8	13.0	3.6	-0.4	-1.4	1.5	-2.5
Number of treatments/medications taken	2.0	3.5	7.7	-2.8	0.9	2.0	-1.8	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	10.6	-1.6	0.5	-1.6	-0.4	3.2
Chest pain or discomfort	2.0	3.0	9.2	-0.8	0.3	-1.7	1.4	3.0
Medication: Co-codamol	1.9	2.2	4.1	-2.0	-1.0	0.6	-1.7	1.6
Time employed in main current job	1.9	2.2	4.5	-2.1	-1.1	2.1	-0.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	4.1	1.7	-0.6	-1.9	0.3	2.0
Family relationship satisfaction	1.9	2.3	4.6	0.9	-1.1	-2.1	1.7	1.5
Mood swings	1.9	3.4	7.1	-2.7	1.0	1.6	-2.4	0.7
Commuting to job workplace: Public transport	1.9	2.3	5.2	2.3	-0.2	-1.8	1.8	-0.1
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.1	2.0	0.5	-1.7	1.3	0.9
Exposure to tobacco smoke at home	1.8	2.0	3.7	1.8	0.3	-0.6	1.6	-1.9
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	5.9	1.0	-0.2	-2.4	1.4	0.7
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.4	-2.1	0.9	1.8	-0.9	-0.6
Allergy	1.7	3.9	9.1	3.0	-1.2	-2.2	1.6	-1.2
Number of children fathered	1.7	1.9	6.6	-1.2	1.2	2.6	-0.4	-0.4
Leg pain on walking	1.7	2.1	4.2	1.3	1.3	0.9	2.1	-1.4
Number of self-reported non-cancer illnesses	1.7	3.0	5.2	-2.1	1.9	2.3	-1.3	0.6
Number of incorrect matches in round	1.6	2.7	9.4	-1.9	-0.0	-0.3	-0.7	3.1
Fluid intelligence score	1.6	3.3	9.2	3.0	-0.2	-1.2	1.1	-2.1
Alcohol intake versus 10 years previously	1.6	2.4	10.0	0.9	-0.4	-0.4	3.2	-0.9
Angina (self-reported)	1.6	2.0	3.5	-1.6	-1.9	0.2	-1.3	1.6
Illnesses of siblings: Diabetes	1.6	2.0	3.7	1.9	-0.1	-1.7	1.7	0.3
Osteoarthritis (self-reported)	1.6	2.1	4.8	-1.9	0.7	1.0	0.9	2.2
Supplements: Fish oil (including cod liver oil)	1.6	2.0	4.5	-2.0	0.7	1.0	-2.1	-0.5
Sensitivity / hurt feelings	1.5	2.6	4.5	-2.0	-0.1	2.1	-2.0	0.5
Hair/balding pattern: Pattern 2	1.5	1.9	7.8	-0.9	-0.3	0.1	0.9	2.8
Pulse rate	1.5	2.6	5.9	0.1	0.0	-2.4	1.1	2.4
Peak expiratory flow (PEF)	1.5	3.6	8.2	-1.7	0.3	-1.3	-2.2	2.9
High blood pressure (siblings)	1.5	2.2	4.1	1.5	-2.0	-2.0	0.0	0.6
Emphysema/chronic bronchitis	1.5	1.7	4.1	-1.3	2.0	-1.0	-0.8	1.0
Medication: Ibuprofen	1.5	1.8	3.7	-0.1	-1.1	-1.3	1.5	1.9
Ulcerative Colitis (UC)	1.4	2.5	6.0	-1.6	-1.8	0.7	-2.4	0.7
Lupus	1.4	2.2	4.6	-0.5	-1.6	-1.7	-0.8	2.2
Hypothyroidism (self reported)	1.4	3.3	7.2	-2.7	0.8	1.8	-1.9	1.3
Diabetes (mother)	1.4	1.8	5.2	1.7	-0.2	-0.7	2.3	-0.5
Medication: Levothyroxine sodium	1.4	2.3	5.7	-2.4	0.4	0.9	-1.3	1.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	5.6	2.4	1.0	-0.2	0.8	-2.0
Headache pain in last month	1.4	2.4	3.5	-1.9	1.6	1.7	-1.5	1.1
Handedness (chirality/laterality): Left-handed	1.4	1.6	4.0	0.1	2.0	2.0	-0.4	-0.5
Guilty feelings	1.4	2.1	4.8	0.3	-0.5	-2.2	0.8	2.2
Financial situation satisfaction	1.4	1.8	3.2	-1.5	1.6	0.7	-0.7	1.8
Neuroticism (Nagel 2018)	1.3	2.9	6.9	-1.8	0.1	-0.3	-2.1	2.6
Age at First Birth	1.3	1.9	7.0	1.1	-2.7	0.1	1.2	0.1
Neuroticism (2016)	1.3	1.8	3.6	-0.6	-0.4	-1.2	-1.9	1.9
Length of working week for main job	1.3	1.4	3.2	-1.8	0.5	0.6	-0.4	1.7
Age started oral contraceptive pill	1.3	1.6	3.1	1.2	0.3	0.7	1.7	-1.8
Depressed Affect (Nagel 2018)	1.2	2.5	5.3	-2.0	0.5	0.7	-2.3	1.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.7	1.1	0.9	-1.2	1.9	0.8
Diabetes (father)	1.2	1.5	3.6	-1.2	1.1	1.9	-0.7	0.9
Chronic bronchitis/emphysema (father)	1.2	1.4	3.3	-0.8	-0.7	-1.5	-0.4	1.8
Medication: Simvastatin	1.2	1.7	3.3	-1.8	1.2	1.8	-0.8	0.1
Noisy workplace	1.2	1.4	3.9	-1.6	-2.0	0.2	-0.7	0.5
Exposure to tobacco smoke outside home	1.2	1.6	5.2	-0.6	2.3	0.2	-1.4	0.5
Medication: Seretide 50 evohaler	1.2	1.4	4.5	-0.9	-2.1	0.0	1.1	0.8
Qualifications: nursing, teaching	1.2	1.9	5.9	1.5	-0.1	-2.4	1.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.2	0.8	1.5	-2.0	-0.2	0.1
Worry (Nagel 2018)	1.1	2.2	5.5	-0.1	-0.2	-2.2	-0.9	2.3
Alzheimer’s Disease (in mother)	1.1	1.3	4.1	-0.7	-1.0	0.7	-0.3	2.0
Chronotype (morning person)	1.1	2.4	4.8	-1.6	0.5	1.9	-2.2	-1.0
Qualifications: CSEs or equivalent	1.1	1.5	3.4	-1.8	-1.7	0.2	-0.8	0.6
Had other major operations	1.1	1.3	2.5	-0.4	1.6	1.3	-1.3	-0.9
Mouth/teeth dental problems	1.1	1.6	3.2	-1.5	0.8	1.8	-1.5	-0.1
Hair/balding pattern: Pattern 3	1.1	1.7	4.5	0.6	0.1	1.8	0.5	-2.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.4	-0.4	-0.8	-1.8	-0.5	1.4
Supplements: Vitamin C	1.1	1.3	3.2	1.8	1.0	-1.2	0.5	0.8
Miserableness	1.1	1.8	3.8	-1.8	0.6	-0.1	-2.0	1.3
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	-1.1	1.6	0.7	-0.3	1.7
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.3	1.4	-0.7	-0.7	1.8	-0.4
Myopia	1.1	1.6	4.2	2.0	-0.4	-1.2	1.6	0.3
Fasting Glucose	1.0	1.2	2.9	1.7	0.7	-1.0	1.3	0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.5	0.9	-0.5	-1.2	1.6	0.7
Relative age of first facial hair	1.0	2.1	3.8	1.9	0.2	-1.6	0.6	-1.9
Relative age voice broke	1.0	1.5	5.2	1.0	0.9	-0.4	-0.5	-2.3
Had menopause	1.0	1.2	6.0	-0.4	2.4	-0.2	-0.2	0.1
Worrier / anxious feelings	1.0	2.0	4.3	-1.2	0.7	-1.4	-1.2	2.1
Prospective memory result	1.0	1.3	3.3	-1.8	-0.9	-0.2	-1.2	0.8
Gout (self-reported)	1.0	1.4	4.2	0.0	-0.1	-2.0	-0.4	1.6
Alcohol intake frequency.	1.0	2.3	7.9	-1.4	-0.8	2.8	-0.8	-0.8
Number of full sisters	1.0	1.2	3.2	-0.1	-1.8	-1.5	0.2	0.8
Long-standing illness, disability or infirmity	1.0	1.5	4.7	-0.8	1.1	-0.8	-0.3	2.2
Illnesses of father: High blood pressure	1.0	1.2	2.4	0.8	-1.2	-1.5	0.1	1.2
Irritable Bowel Disease (IBD)	0.9	2.2	4.3	-1.4	-1.6	1.1	-2.1	0.8
HbA1C	0.9	1.0	3.5	1.0	-0.6	0.3	0.1	-1.9
Primary Biliary Cirrhosis	0.9	1.3	3.0	1.2	-1.7	-1.3	0.6	0.5
Heel T-Score	0.9	7.2	27.0	-2.3	0.5	5.2	-1.8	-0.5
Neuroticism	0.9	2.3	5.1	-0.6	0.8	-1.6	-1.7	2.3
Alcohol usually taken with meals	0.9	1.4	5.1	1.3	0.3	0.4	0.1	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.2	0.2	2.3	1.9	0.5	-0.8
Pain all over the body in last month	0.9	0.9	2.2	0.6	0.6	-1.2	0.5	1.5
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.8	-0.1	-1.7	-0.2	0.4	1.5
Shortness of breath walking on level ground	0.9	1.0	2.3	-0.9	1.5	0.9	0.7	0.9
Medication: Blood pressure	0.9	1.6	5.6	-1.2	0.3	0.7	-2.4	0.7
Loneliness, isolation	0.9	1.3	2.4	-0.8	-1.1	-1.3	-0.6	1.5
Medication: Gliclazide	0.9	1.0	2.5	1.4	-0.3	-1.6	-0.4	-0.8
Medication: Lisinopril	0.9	1.2	3.4	-1.9	0.0	1.3	-0.7	0.6
Alcohol drinker status: Never	0.9	1.1	3.7	-1.9	0.4	0.7	-0.2	0.9
Heart disease (siblings)	0.9	1.1	3.0	-1.7	1.2	0.9	-0.0	-0.1
Alzheimer’s Disease (in father)	0.8	0.9	3.9	-0.3	2.0	-0.2	-0.7	-0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	3.0	-1.2	-0.2	0.4	-1.1	1.7
Ulcerative Colitis	0.8	1.1	3.1	-0.8	-1.8	-0.3	-1.3	0.1
Maternal smoking around birth	0.8	1.1	2.7	-0.7	-0.5	-0.0	-1.6	1.5
Nervous feelings	0.8	1.4	4.5	-1.3	-0.3	0.1	-0.9	2.1
Neuroticism score	0.8	1.7	2.7	-0.9	1.3	-0.7	-1.7	1.6
Happiness	0.8	1.0	2.8	0.7	-1.1	-0.3	1.7	-0.5
Eye problems/disorders: None of the above	0.8	1.0	2.2	0.7	-0.4	1.0	-1.5	-1.0
Medication: Allopurinol	0.8	1.1	2.3	-0.3	1.5	-0.8	-1.0	1.2
Suffer from ‘nerves’	0.8	1.2	4.3	0.6	0.3	-2.1	0.1	1.1
Had major operations	0.8	0.9	1.7	1.3	-1.2	-0.1	1.2	-0.3
Age at last live birth	0.8	1.2	2.7	1.4	-0.0	-1.0	1.6	0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.5	1.6	0.8	-0.7	0.3	-1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	2.4	-0.1	-1.5	-1.4	0.3	0.3
Crohns Disease (2017)	0.7	1.6	2.0	-1.4	-1.2	1.2	-1.2	1.3
Major Depression (MDD)	0.7	0.8	2.9	-0.6	-0.2	-0.9	0.4	1.7
Coronary Artery Disease (CAD)	0.7	0.9	2.0	-0.7	0.0	1.4	-1.3	0.4
Severe depression (siblings)	0.7	0.8	2.0	0.3	-0.5	-1.1	-1.4	0.7
Average weekly fortified wine intake	0.7	0.8	1.8	0.6	-0.2	-1.2	1.4	0.5
Serious illness, injury or assault to yourself	0.7	0.9	1.4	1.1	0.3	-0.8	1.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.5	1.2	-0.7	-1.6	0.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.5	-1.6	0.5	0.2	-0.2	1.5
Medication: Paracetamol	0.7	1.1	2.7	-1.0	0.7	0.8	-1.6	0.8
Birth weight	0.7	1.4	3.0	1.7	-0.7	-1.4	0.7	-1.0
Migraine (self-reported)	0.7	0.8	1.6	-1.2	-0.3	1.3	-0.7	0.7
Pulse rate, automated reading	0.7	2.2	5.8	0.6	0.4	-2.4	0.4	2.1
Friendships satisfaction	0.7	0.9	3.7	0.3	-1.9	-0.6	0.5	0.0
Eye problems/disorders: Cataract	0.7	0.9	2.2	-1.2	0.6	0.6	0.1	1.5
Eye problems/disorders: Glaucoma	0.7	0.9	1.8	-1.1	0.7	1.3	-0.2	-1.0
Average weekly beer plus cider intake	0.7	1.1	2.1	-1.4	1.4	-0.4	-1.0	0.4
LDL Cholesterol	0.6	0.9	2.9	0.1	-0.7	-0.2	-1.0	1.7
Supplements: Glucosamine	0.6	0.8	1.8	0.2	1.1	0.8	1.3	0.5
Medication: Atenolol	0.6	0.7	1.1	-1.0	-0.6	1.0	-0.6	-0.9
High blood pressure (mother)	0.6	0.8	3.1	-0.5	-0.4	-0.5	0.1	1.8
Hearing difficulty/problems with background noise	0.6	0.9	1.3	-0.6	-0.5	-1.2	1.1	1.1
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	0.8	0.1	-1.3	1.0	0.2
Tense / ‘highly strung’	0.6	1.0	3.8	0.8	-0.2	-1.9	-0.5	0.5
Birth weight of first child	0.6	1.1	3.4	1.4	0.0	0.1	0.0	-1.9
Loud music exposure frequency	0.6	0.7	1.1	0.6	-0.9	-0.6	0.8	1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.1	1.4	-0.1	-0.6	1.0	-0.6
Pulse wave peak to peak time	0.6	0.8	1.5	-0.9	0.2	1.2	-1.1	0.0
Health satisfaction	0.6	0.7	2.7	-0.8	1.6	0.4	0.0	0.3
Illnesses of father: Heart disease	0.6	0.8	1.8	0.1	-0.7	-1.3	0.9	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.4	0.5	-0.4	-1.6	0.4	-0.3
Mineral and other dietary supplements	0.6	0.8	1.8	1.3	-0.5	-0.9	0.8	-0.8
Breast cancer (self-reported)	0.6	0.7	1.9	0.4	1.1	-1.4	0.2	0.5
Average weekly champagne plus white wine intake	0.6	0.9	2.6	1.6	-0.1	-0.9	0.9	-0.5
Hearing aid user	0.6	0.7	2.7	0.7	-0.5	0.2	1.6	0.2
Mother’s age at death	0.6	0.8	2.1	1.2	-0.3	-0.4	0.3	-1.4
Medication: Paracetamol	0.6	0.9	1.5	-0.9	0.9	1.2	-0.9	0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	-0.4	-0.8	-0.8	-0.6	1.3
Depression (Nagel 2018)	0.5	0.7	1.9	-0.6	1.4	-0.6	0.9	0.3
Ovarian Cancer	0.5	0.6	2.1	-0.9	-0.0	-0.3	-0.3	1.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	0.2	0.4	0.9	-1.1	-1.1
Crohns Disease (2012)	0.5	0.7	2.0	-0.9	-1.4	0.4	-0.7	0.5
Blood Eosinophil Count	0.5	3.7	7.5	-2.4	0.9	2.0	-2.7	0.7
Waist Hip Ratio (WHR)	0.5	2.1	6.4	1.5	0.0	-2.5	0.9	1.1
Hand grip strength (left)	0.5	1.2	4.3	-0.4	0.2	0.8	-2.1	-1.0
Average weekly spirits intake	0.5	0.6	1.5	-0.8	-0.1	0.4	-1.2	0.8
Supplements: Zinc	0.5	0.5	0.9	-0.9	-0.4	-0.4	-0.9	0.8
Hand grip strength (right)	0.5	1.5	4.4	0.0	-0.3	0.3	-2.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.4	-1.6	0.3	-0.8	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.5	0.3	1.9	1.4	-0.0	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.0	-1.1	0.9	1.4	-1.1	-0.5
Multivitamins +/- minerals	0.5	0.7	2.0	1.0	0.4	-1.4	0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.4	0.2	0.0	-0.9	1.2	0.8
Forced vital capacity (FVC)	0.5	1.9	4.8	-1.0	0.7	-0.6	-2.2	1.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.4	-1.0	0.6	-0.7	-2.1	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.5	-0.1	-0.7	-0.7	1.2	1.0
Breastfed as a baby	0.5	0.6	1.1	0.7	0.8	-1.0	-0.6	-0.7
Pulse wave reflection index	0.5	0.6	1.0	0.8	0.8	-0.7	0.0	-1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.4	0.6	-0.3	0.2	1.8	-0.5
Medication: Amlodipine	0.5	0.7	1.4	1.2	-0.7	-0.7	0.2	1.1
Number of full brothers	0.5	0.6	1.6	-0.7	-0.3	-0.5	-0.6	1.3
Age at first live birth	0.5	0.9	2.0	1.0	1.4	-0.7	0.9	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	2.4	1.5	-0.4	-1.1	0.4	-0.8
Heart disease (mother)	0.5	0.6	1.5	0.4	0.5	-0.1	-1.1	-1.2
Knee pain experienced in last month	0.5	0.7	2.8	-0.5	1.7	-0.2	-0.6	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.2	-0.1	0.5	-0.4	1.1	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	0.6	0.8	0.8	0.4	1.5
High cholesterol (Self-reported)	0.5	0.9	3.5	-0.6	1.9	0.6	-0.6	-0.5
Number of operations (self-reported)	0.5	0.7	1.6	1.1	-0.1	0.5	0.9	-1.2
Irritability	0.5	0.9	1.8	-0.7	1.4	-0.1	-0.8	1.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.6	-0.1	1.6	0.6	-0.2	0.4
Bipolar Disorder (2018)	0.4	0.6	1.4	1.2	-0.6	-0.8	0.4	-0.5
Rheumatoid Arthritis	0.4	0.5	0.9	-0.4	-0.9	0.4	-0.6	0.9
Allergy or Eczema	0.4	1.1	3.2	-1.1	0.3	1.8	-0.3	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.0	-0.6	1.4	0.4	-0.1	1.1
Medication: Metformin	0.4	0.5	1.6	-0.5	-1.3	-0.7	-0.1	0.5
Fed-up feelings	0.4	0.7	1.3	-0.8	0.1	0.6	-1.1	1.1
Illnesses of siblings	0.4	0.6	2.2	-0.5	0.1	1.5	-0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	0.7	-0.3	0.6	1.0	-0.6
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	-0.3	-0.9	-1.3	0.9	0.3
Medication: Cholesterol lowering	0.4	0.6	2.1	-0.8	0.4	-0.4	-1.4	0.5
Lung cancer (father)	0.4	0.5	0.8	-0.8	0.8	0.9	0.5	0.2
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	0.7	-0.5	-0.6	1.0	-0.0
Glaucoma (self-reported)	0.4	0.5	0.8	-0.8	0.5	0.6	-0.9	-0.6
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	0.5	0.7	-0.6	-0.5
Ever had bowel cancer screening	0.4	0.5	1.7	-0.0	0.3	-1.3	0.5	0.6
Medication for cholesterol	0.4	0.6	1.6	0.9	-0.5	-1.3	0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	-0.8	0.3	0.3	-0.8	-1.1
Ever depressed for a whole week	0.4	0.5	1.4	-0.5	-1.2	-0.4	0.7	0.4
Cholesterol lowering medication	0.4	0.5	1.3	-0.5	1.2	0.9	-0.4	0.2
Bipolar Disorder (2011)	0.3	0.3	1.2	0.4	-0.5	-1.1	0.2	0.0
HDL Cholesterol	0.3	0.6	1.4	0.4	0.6	-1.2	0.2	0.9
Triglycerides	0.3	0.5	1.2	-0.3	-0.7	0.6	-0.5	1.1
Blood Red Count	0.3	3.1	6.6	-0.7	-2.6	1.9	-0.6	-2.1
Systolic Blood Pressure	0.3	1.3	3.1	1.5	-0.4	-1.8	0.3	1.0
Cardiovascular Disease	0.3	0.9	3.8	0.5	2.0	-0.4	-0.4	0.4
Lung FEV1/FVC ratio	0.3	1.3	3.0	-1.7	1.6	0.3	-0.1	1.0
Hearing difficulty/problems: Yes	0.3	0.5	2.0	0.6	1.4	-0.0	0.1	-0.2
Current tobacco smoking	0.3	0.5	1.0	-1.0	0.8	-0.5	-0.8	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.6	0.9	-1.1	0.0	0.4
Heart attack	0.3	0.3	1.0	-1.0	0.0	0.7	-0.4	-0.0
Diabetes (self-reported)	0.3	0.5	2.0	-0.5	-0.1	-0.2	-0.1	1.4
Trunk fat-free mass	0.3	1.5	4.3	1.0	-0.3	-2.1	0.2	1.4
Medication: Lansoprazole	0.3	0.3	0.8	0.3	0.6	0.3	0.9	0.5
Blood clot in the leg (DVT)	0.3	0.4	1.5	0.0	-0.6	-0.4	-0.1	1.2
Worry too long after embarrassment	0.3	0.5	1.5	0.4	0.9	-1.2	0.2	-0.1
Medication: Omeprazole	0.3	0.4	1.1	0.1	0.9	0.2	0.1	1.0
Overall health rating	0.3	0.7	1.6	-0.9	0.5	0.0	-0.9	1.3
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.0	0.2	-0.6	1.0	1.0
Osteoporosis (self-reported)	0.3	0.3	0.6	0.8	0.5	0.0	0.3	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	0.1	0.6	0.3	-0.6	-1.0
Smoking status: Current	0.3	0.5	1.0	-0.7	0.5	-1.0	-0.6	-0.2
Medication: Atorvastatin	0.3	0.4	1.0	0.2	1.0	0.4	-0.5	0.5
Diastolic blood pressure, automated reading	0.3	1.0	3.9	0.7	-0.4	-2.0	-0.6	-0.2
Unable to work because of sickness or disability	0.3	0.4	1.1	0.6	0.2	-1.0	0.5	0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.5	-0.4	-0.6	0.0	1.1
Breast Cancer	0.2	0.4	0.9	0.0	0.1	-0.9	-0.0	1.0
Blood White Count	0.2	1.4	3.4	-0.5	1.1	1.8	-1.4	-0.4
BMI	0.2	1.0	1.8	-0.4	0.8	1.3	-1.3	-0.7
Hair Pigment	0.2	5.3	10.2	-2.5	3.2	2.0	-2.2	1.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	-0.8	0.9	0.2	0.2	0.3
Systolic blood pressure, automated reading	0.2	0.5	0.8	0.9	-0.9	-0.9	-0.1	-0.4
Vitamin and mineral supplements	0.2	0.3	1.2	-0.5	0.0	1.1	0.3	-0.2
Pack years adult smoking proportion	0.2	0.3	1.3	-0.1	-0.5	-1.1	0.1	-0.1
Leg fat-free mass (left)	0.2	1.1	3.2	0.0	-0.3	-1.5	-0.4	1.8
Trunk fat percentage	0.2	0.8	2.3	-0.8	0.7	1.5	-0.6	-0.7
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.5	0.4	0.3	0.4	-0.6
Impedance of leg (left)	0.2	0.9	2.6	-0.3	0.7	1.6	0.4	-1.0
Leg predicted mass (left)	0.2	1.2	3.2	0.0	-0.2	-1.5	-0.4	1.8
Waist circumference	0.2	0.6	1.8	0.8	0.5	-1.3	0.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	0.1	0.7	-0.6	0.3	0.6
Medication: Ramipril	0.2	0.3	0.9	-0.3	-0.1	0.6	-0.3	1.0
Falls in the last year	0.2	0.2	0.5	-0.4	-0.0	-0.7	0.7	0.4
Number of live births	0.2	0.3	0.8	0.7	-0.9	0.3	0.0	0.0
Depression (self-reported)	0.2	0.3	1.3	0.3	0.1	-0.1	-0.1	-1.2
Illnesses of mother	0.2	0.2	0.8	0.3	0.2	0.1	0.3	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	-0.4	0.3	-1.0	-1.1	0.9
Impedance of arm (left)	0.2	0.7	2.7	-0.5	-0.4	1.6	0.5	-0.6
Trunk predicted mass	0.2	1.4	4.0	1.0	-0.3	-2.0	0.2	1.4
Standing height	0.2	1.9	4.8	0.6	-0.5	-1.8	0.9	2.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.4	-0.5	0.3	-0.7	-1.1	1.2
Body fat percentage	0.2	0.6	1.2	-0.6	0.8	1.1	-0.8	-0.6
Arm fat-free mass (right)	0.2	0.8	2.0	0.3	0.6	-1.4	-0.3	1.2
Comparative body size at age 10	0.2	0.6	0.9	-0.9	0.6	0.8	-0.9	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.1	0.1	-1.0	-0.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.4	0.2	-0.2	-0.7	0.5
Arm predicted mass (right)	0.2	1.0	2.6	0.2	0.6	-1.6	-0.4	1.4
Comparative height size at age 10	0.2	1.0	2.9	0.3	-0.8	-1.1	0.1	1.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.0	0.5	-0.1	-0.7	-0.9
Whole body fat-free mass	0.2	1.2	3.0	0.4	-0.1	-1.6	-0.2	1.7
Leg fat-free mass (right)	0.2	1.0	2.8	-0.2	-0.2	-1.2	-0.5	1.7
Whole body water mass	0.2	1.1	2.7	0.4	-0.1	-1.6	-0.2	1.6
Leg predicted mass (right)	0.2	1.0	2.9	-0.3	-0.2	-1.2	-0.6	1.7
Wears glasses or contact lenses	0.2	0.3	1.0	0.3	-0.0	-0.2	0.4	1.0
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	0.5	-0.1	-0.2	0.8
Basal metabolic rate	0.2	0.8	2.1	0.3	0.0	-1.4	-0.3	1.4
Arm fat-free mass (left)	0.2	0.9	2.0	0.1	0.7	-1.3	-0.3	1.4
Pack years of smoking	0.2	0.3	0.9	-0.1	-0.5	-1.0	0.0	-0.4
Impedance of whole body	0.2	1.0	3.5	-0.6	0.2	1.9	0.7	-0.6
Arm predicted mass (left)	0.2	0.8	1.9	0.2	0.4	-1.4	0.1	1.3
Prostate Cancer	0.1	0.1	0.2	-0.2	0.3	0.3	-0.4	0.4
Mean Putamen Volume	0.1	0.1	0.3	0.2	-0.1	-0.5	0.3	0.0
Blood Platelet Count	0.1	0.7	1.2	-0.5	-0.3	-1.0	1.1	0.9
Height	0.1	2.9	4.9	1.7	-1.9	-1.7	2.2	0.3
Lung FVC	0.1	0.6	1.3	-0.1	1.2	0.2	-1.1	-0.5
Tanning	0.1	1.8	4.4	-1.0	1.0	2.1	-1.3	-0.8
Impedance of leg (right)	0.1	0.4	0.8	0.3	0.2	0.9	0.8	-0.8
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.1	0.3	-0.3	-0.2	0.4
High blood pressure	0.1	0.2	0.5	0.2	0.7	-0.6	-0.3	0.3
Sitting height	0.1	0.9	2.2	-0.8	-1.5	-0.2	-0.2	1.2
Body mass index (BMI)	0.1	0.3	0.6	-0.1	0.6	0.2	-0.8	-0.5
Trunk fat mass	0.1	0.3	0.5	-0.4	0.5	0.6	-0.7	-0.0
Weight	0.1	0.3	0.6	0.1	0.2	-0.8	-0.3	0.7
Impedance of arm (right)	0.1	0.6	2.1	-0.2	-0.3	1.4	0.8	-0.1
Arm fat percentage (right)	0.1	0.6	1.2	-0.3	0.9	1.1	-0.7	-0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.7	-0.8	0.4	-0.0	-0.1
Medication: Aspirin	0.1	0.1	0.2	-0.3	-0.5	0.2	-0.1	0.5
Hypertension (Self-reported)	0.1	0.2	0.4	0.1	0.6	-0.6	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	0.5	0.0	-0.2	-0.2	-0.7
Arm fat percentage (left)	0.1	0.6	1.2	-0.5	0.6	1.1	-0.8	-0.7
Medication: Aspirin	0.1	0.1	0.4	-0.2	0.1	0.0	-0.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.3	-0.3	-0.7	-0.5	-0.6
Medication: Blood pressure	0.1	0.1	0.3	-0.0	0.2	0.3	0.5	-0.4
Leg fat percentage (left)	0.1	0.2	0.5	-0.2	0.4	0.4	-0.4	-0.7
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.0	-0.3	0.5	0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.6	-0.1	0.4	-0.2	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.6	0.2	0.3	-0.4	0.1
Age when periods started (menarche)	0.0	0.1	0.2	0.0	0.2	-0.2	0.4	0.4
Hip circumference	0.0	0.0	0.1	0.3	0.1	-0.1	-0.2	0.1
Arm fat mass (right)	0.0	0.1	0.3	0.1	0.6	0.2	-0.4	-0.1
Leg fat percentage (right)	0.0	0.1	0.4	0.1	0.4	-0.0	-0.3	-0.6
Whole body fat mass	0.0	0.1	0.4	-0.1	0.5	0.3	-0.6	-0.1
Leg fat mass (right)	0.0	0.2	0.6	0.1	0.3	-0.4	-0.7	0.0
Arm fat mass (left)	0.0	0.2	0.4	-0.1	0.6	0.5	-0.6	-0.2
Leg fat mass (left)	0.0	0.2	0.8	-0.1	0.3	-0.1	-0.9	0.1

Hub : Genes

MAN2A1

Models

Trait associations