[Hub]/) : Traits : Heel T-Score : ← →

chr5:111,499,732-112,950,045

Best TWAS P=7.03e-14 · Best GWAS P=1.15e-14 conditioned to 0.0246

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SRP19	0.08	0.06	lasso	5	0.07	1.3e-08	6.2	-6.5	7.1e-11	-0.72	0.71	0.29	FALSE
2	GTEx	Adipose Subcutaneous	REEP5	0.10	0.09	lasso	2	0.05	2.8e-05	5.4	5.9	4.1e-09	0.68	0.53	0.45	FALSE
3	GTEx	Adipose Visceral Omentum	REEP5	0.09	0.05	lasso	5	0.02	4.9e-02	6.4	6.3	3.0e-10	0.72	0.21	0.47	FALSE
4	GTEx	Artery Aorta	REEP5	0.17	0.07	lasso	13	0.10	4.2e-06	7.2	7.5	7.0e-14	0.90	0.09	0.90	TRUE
5	GTEx	Artery Tibial	REEP5	0.17	0.12	lasso	5	0.13	3.0e-10	6.4	6.2	4.8e-10	0.66	0.90	0.10	FALSE
6	GTEx	Cells Transformed fibroblasts	CTC-487M23.5	0.07	0.03	lasso	3	0.03	2.9e-03	-6.7	-7.1	9.8e-13	-0.88	0.04	0.86	FALSE
7	GTEx	Colon Transverse	REEP5	0.12	0.14	lasso	2	0.14	4.4e-07	6.5	6.6	4.5e-11	0.75	0.65	0.32	FALSE
8	GTEx	Esophagus Gastroesophageal Junction	REEP5	0.18	0.03	lasso	3	0.03	3.7e-02	6.9	7.0	3.8e-12	0.82	0.03	0.90	FALSE
9	GTEx	Esophagus Mucosa	REEP5	0.19	0.10	lasso	5	0.09	1.5e-06	6.9	6.6	4.5e-11	0.78	0.12	0.84	FALSE
10	GTEx	Esophagus Muscularis	REEP5	0.18	0.09	lasso	4	0.14	5.9e-09	6.5	6.6	4.3e-11	0.79	0.35	0.65	FALSE
11	GTEx	Nerve Tibial	REEP5	0.16	0.13	lasso	3	0.10	9.2e-08	6.4	6.4	2.0e-10	0.68	0.93	0.07	FALSE
12	GTEx	Nerve Tibial	XBP1P1	0.06	0.05	lasso	2	0.04	6.1e-04	5.5	6.4	1.5e-10	0.87	0.06	0.90	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	REEP5	0.11	0.10	lasso	7	0.10	6.3e-06	5.4	6.0	1.7e-09	0.68	0.35	0.61	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.5	0.10	0.06	lasso	3	0.05	6.7e-04	6.0	6.4	1.2e-10	0.77	0.13	0.66	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	CTC-487M23.7	0.08	0.09	enet	7	0.10	3.9e-06	6.2	6.9	5.6e-12	0.84	0.18	0.76	FALSE
16	GTEx	Skin Sun Exposed Lower leg	REEP5	0.08	0.05	lasso	4	0.03	1.9e-03	5.4	6.1	1.1e-09	0.73	0.52	0.43	FALSE
17	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.5	0.17	0.07	lasso	6	0.06	7.7e-06	6.0	6.4	1.6e-10	0.72	0.54	0.46	FALSE
18	GTEx	Skin Sun Exposed Lower leg	CTC-487M23.7	0.06	0.07	lasso	1	0.04	2.4e-04	6.0	6.0	2.2e-09	0.67	0.42	0.44	FALSE
19	GTEx	Testis	REEP5	0.22	0.14	lasso	5	0.14	6.6e-07	6.5	6.8	7.2e-12	0.80	0.28	0.67	FALSE
20	GTEx	Thyroid	REEP5	0.09	0.02	lasso	5	0.03	3.3e-03	5.4	5.3	1.1e-07	0.60	0.19	0.24	FALSE
21	METSIM	Adipose	REEP5	0.05	0.00	bslmm	475	0.01	6.8e-03	6.2	6.2	7.1e-10	0.62	0.42	0.37	FALSE
22	NTR	Blood	REEP5	0.03	0.04	lasso	9	0.04	3.3e-12	7.2	7.0	3.5e-12	0.86	0.14	0.86	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	REEP5	0.08	0.03	lasso	3	0.02	1.3e-03	-5.6	5.2	1.8e-07	0.56	0.34	0.06	FALSE
24	YFS	Blood	SRP19	0.02	0.01	bslmm	456	0.00	2.9e-02	6.5	5.7	1.1e-08	0.66	0.03	0.81	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	APC	0.04	0.02	blup	75	0.02	4.8e-03	6.4	5.4	7.3e-08	0.55	0.08	0.29	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRP19	0.05	0.04	lasso	3	0.04	3.7e-05	6.2	-6.4	1.3e-10	-0.72	0.72	0.20	FALSE
27	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SRP19	0.10	0.02	blup	44	0.02	6.2e-02	6.5	-5.2	2.1e-07	-0.60	0.01	0.18	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRP19	0.05	0.05	lasso	1	0.05	4.5e-06	6.5	-6.5	9.8e-11	-0.81	0.17	0.79	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRP19	0.07	0.03	lasso	4	0.02	2.4e-02	6.5	-6.4	1.5e-10	-0.80	0.03	0.63	FALSE
30	The Cancer Genome Atlas	Stomach Adenocarcinoma	REEP5	0.03	0.02	blup	47	0.03	4.1e-03	5.4	6.6	3.7e-11	0.79	0.05	0.28	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	APC	0.02	0.02	enet	5	0.02	4.2e-03	-7.3	7.4	1.1e-13	0.95	0.03	0.87	FALSE