[Hub]/) : Traits : Heel T-Score : ← →

chr8:70,788,124-72,974,329

Best TWAS P=9.23e-57 · Best GWAS P=1.22e-55 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EYA1	0.05	0.00	blup	579	0.01	2.1e-02	15.7	-15.5	1.8e-54	-0.72	0.02	0.90	TRUE
2	CommonMind	Brain Pre-frontal Cortex	LACTB2	0.07	0.09	lasso	5	0.08	3.7e-10	15.0	-15.3	7.6e-53	-0.85	0.92	0.08	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LOC286190	0.04	0.01	bslmm	317	0.03	2.3e-04	15.1	-11.9	1.2e-32	-0.81	0.12	0.81	FALSE
4	CommonMind	Brain Pre-frontal Cortex	XKR9	0.26	0.52	lasso	13	0.51	1.6e-72	15.2	15.5	4.1e-54	0.97	0.89	0.11	FALSE
5	GTEx	Artery Tibial	LACTB2	0.17	0.02	enet	26	0.06	1.0e-05	-1.4	-5.7	1.0e-08	-0.44	0.78	0.16	FALSE
6	GTEx	Cells Transformed fibroblasts	LACTB2	0.05	0.00	enet	4	0.02	1.6e-02	13.4	-14.1	4.1e-45	-0.81	0.14	0.66	FALSE
7	GTEx	Heart Atrial Appendage	LACTB2	0.19	0.13	enet	43	0.16	1.6e-07	15.2	-14.7	6.2e-49	-0.85	0.06	0.94	FALSE
8	GTEx	Heart Left Ventricle	LACTB2	0.07	0.01	lasso	4	0.02	2.5e-02	13.3	-14.8	1.9e-49	-0.83	0.08	0.87	FALSE
9	GTEx	Lung	LACTB2	0.05	0.03	lasso	6	0.02	1.4e-02	-14.6	-15.4	2.7e-53	-0.84	0.13	0.77	FALSE
10	GTEx	Muscle Skeletal	LACTB2	0.09	0.07	enet	19	0.09	2.9e-09	-14.6	-14.3	1.9e-46	-0.87	0.59	0.41	FALSE
11	GTEx	Nerve Tibial	LACTB2	0.07	0.06	lasso	2	0.04	1.5e-03	15.1	-14.7	4.1e-49	-0.94	0.27	0.69	FALSE
12	GTEx	Pancreas	LACTB2	0.13	0.11	enet	19	0.05	3.3e-03	15.1	-15.0	4.6e-51	-0.96	0.06	0.91	FALSE
13	GTEx	Pituitary	LACTB2	0.25	0.08	lasso	8	0.13	4.3e-04	13.4	-10.7	7.6e-27	-0.60	0.19	0.12	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	LACTB2	0.07	0.07	lasso	2	0.07	7.5e-05	15.0	-15.1	8.8e-52	-0.85	0.14	0.83	FALSE
15	GTEx	Skin Sun Exposed Lower leg	LACTB2	0.05	0.03	lasso	3	0.04	4.6e-04	14.9	-15.6	7.6e-55	-0.88	0.20	0.77	FALSE
16	GTEx	Stomach	LACTB2	0.10	0.08	enet	21	0.04	3.4e-03	-14.3	-15.1	1.3e-51	-0.91	0.14	0.86	FALSE
17	GTEx	Testis	LACTB2	0.10	0.06	enet	12	0.08	2.9e-04	4.0	-9.6	9.0e-22	-0.59	0.25	0.27	FALSE
18	GTEx	Whole Blood	LACTB2	0.06	0.00	enet	21	0.02	3.1e-03	-14.7	-8.1	5.7e-16	-0.35	0.09	0.16	FALSE
19	METSIM	Adipose	XKR9	0.17	0.37	enet	33	0.38	8.6e-60	15.3	-15.7	2.9e-55	-0.96	0.90	0.10	FALSE
20	NTR	Blood	LACTB2	0.02	0.01	blup	315	0.01	2.0e-04	12.1	-11.4	6.0e-30	-0.73	0.26	0.68	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	LACTB2	0.05	0.07	lasso	3	0.08	6.3e-10	-14.7	-15.5	3.3e-54	-0.87	0.26	0.74	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	XKR9	0.22	0.38	bslmm	366	0.40	1.0e-54	15.2	-14.7	7.3e-49	-0.92	0.72	0.28	FALSE
23	YFS	Blood	TRAM1	0.02	0.01	enet	22	0.02	8.1e-07	14.9	-11.3	2.1e-29	-0.64	0.07	0.91	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LACTB2	0.03	0.02	blup	41	0.02	1.6e-02	2.6	-8.2	3.0e-16	-0.47	0.02	0.15	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XKR9	0.31	0.44	enet	13	0.44	1.4e-40	15.2	-15.0	4.6e-51	-0.93	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	XKR9	0.25	0.51	lasso	8	0.51	2.4e-123	15.1	-15.2	2.6e-52	-0.95	0.02	0.98	FALSE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	XKR9	0.35	0.42	enet	12	0.42	3.5e-22	15.2	-15.5	3.5e-54	-0.96	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	XKR9	0.32	0.44	lasso	12	0.45	7.9e-29	15.1	-15.1	2.1e-51	-0.95	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Esophageal Carcinoma	XKR9	0.12	0.16	blup	44	0.13	6.4e-05	15.1	-14.5	1.1e-47	-0.92	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	XKR9	0.18	0.15	enet	19	0.20	1.1e-06	15.2	-15.7	8.0e-56	-0.94	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LACTB2	0.03	0.03	lasso	1	0.03	1.7e-04	-14.4	-14.4	8.1e-47	-0.81	0.05	0.49	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	XKR9	0.21	0.38	lasso	6	0.38	4.6e-45	15.1	-15.4	2.6e-53	-0.95	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XKR9	0.34	0.51	enet	16	0.51	9.7e-66	15.1	-14.5	1.1e-47	-0.94	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	XKR9	0.45	0.55	lasso	3	0.57	1.2e-38	15.1	-15.0	7.0e-51	-0.95	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	LACTB2	0.03	0.01	enet	10	0.02	4.1e-03	3.8	-9.9	2.5e-23	-0.73	0.01	0.85	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	XKR9	0.18	0.35	enet	13	0.34	7.7e-40	15.1	-15.4	1.4e-53	-0.96	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	XKR9	0.40	0.46	lasso	5	0.46	5.5e-24	15.1	-15.0	1.2e-50	-0.95	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	XKR9	0.31	0.43	enet	14	0.43	1.9e-54	15.2	-14.8	8.0e-50	-0.94	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	XKR9	0.28	0.46	lasso	9	0.46	1.7e-57	15.2	-15.4	2.7e-53	-0.96	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	XKR9	0.32	0.53	lasso	7	0.52	6.5e-40	15.3	-15.2	2.9e-52	-0.95	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	XKR9	0.23	0.32	lasso	7	0.34	3.7e-15	15.1	-14.4	4.0e-47	-0.91	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LACTB2	0.12	0.09	lasso	2	0.11	3.7e-05	-14.4	-14.9	5.8e-50	-0.87	0.01	0.96	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	XKR9	0.47	0.58	enet	13	0.59	1.5e-28	15.1	-15.7	1.8e-55	-0.94	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	LACTB2	0.03	0.02	lasso	3	0.02	6.1e-03	-14.6	-15.0	9.8e-51	-0.85	0.02	0.81	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	XKR9	0.51	0.62	lasso	7	0.64	4.7e-86	15.2	-15.4	1.4e-53	-0.95	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Rectum Adenocarcinoma	XKR9	0.40	0.50	enet	18	0.52	2.6e-14	15.1	-15.5	1.7e-54	-0.95	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Soft Tissue Sarcoma	XKR9	0.30	0.36	blup	44	0.37	3.8e-23	15.2	-15.6	3.9e-55	-0.95	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Skin Cutaneous Melanoma	XKR9	0.29	0.13	blup	44	0.14	1.8e-04	13.4	-14.6	1.6e-48	-0.86	0.02	0.95	FALSE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	XKR9	0.22	0.26	enet	13	0.24	1.8e-17	15.1	-15.0	5.9e-51	-0.95	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	XKR9	0.33	0.33	enet	21	0.34	9.6e-13	15.2	-15.7	1.1e-55	-0.95	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	LACTB2	0.03	0.01	enet	5	0.01	6.1e-02	15.2	-13.6	2.3e-42	-0.85	0.01	0.81	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	XKR9	0.38	0.55	lasso	9	0.56	2.5e-65	15.2	-15.2	6.2e-52	-0.96	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	XKR9	0.24	0.24	lasso	4	0.25	1.3e-07	15.3	-15.9	9.2e-57	-0.96	0.01	0.99	TRUE