TWAS hub - TRAM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2820	0.0820	4.6e-05	0.018	NA	0.075	NA	0.014	0.03500	NA	6.0e-05	NA	0.05500
2	GTEx	Cells Transformed fibroblasts	0.0640	0.0290	2.0e-03	0.029	NA	0.029	NA	0.021	0.00270	NA	3.0e-03	NA	0.00970
3	ROSMAP	Brain Pre-frontal Cortex	0.0455	0.0225	1.4e-03	0.003	0.000	0.007	0.007	0.005	0.12000	3.0e-01	3.3e-02	4.0e-02	0.06500
4	YFS	Blood	0.0222	0.0104	4.1e-05	0.010	0.016	0.018	0.017	0.011	0.00020	5.4e-06	8.1e-07	1.4e-06	0.00012
5	TCGA	Bladder Urothelial Carcinoma	0.0640	0.0360	2.8e-03	0.035	0.019	0.022	NA	0.022	0.00056	9.6e-03	4.9e-03	NA	0.00500
6	TCGA	Colon Adenocarcinoma	0.0780	0.0450	8.3e-03	0.004	0.027	0.036	NA	0.025	0.18000	1.1e-02	3.4e-03	NA	0.01300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Verbal and Numeric Reasoning (VNR)	5.2	12.5	31.1	-5.6	-4.1	-1.1	-1.9	-1.7	-4.4
Heel bone mineral density (BMD) T-score, automated (left)	4.6	10.5	28.7	-3.3	-3.1	-1.0	-5.4	-1.6	-3.2
Heel T-Score	4.0	31.5	127.7	-1.4	-2.2	-4.8	-11.3	-4.9	-2.7
Prostate Cancer	3.3	4.6	8.9	-2.3	-2.6	-2.0	-1.4	-1.0	-3.0
Waist Hip Ratio (WHR)	3.1	14.1	34.6	-2.9	-5.7	-0.2	-5.9	-1.6	-2.6
Hair/balding pattern: Pattern 2	3.1	3.9	7.1	-0.8	-2.7	-2.4	-1.1	-1.3	-2.7
Intelligence (Savage-Jansen 2018)	3.0	9.3	24.7	-5.0	-3.6	0.4	-2.4	-0.8	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	19.2	-1.8	-3.0	-0.4	-4.4	-1.4	-2.8
Fluid intelligence score	2.9	6.0	11.1	-3.2	-2.9	-0.6	-1.1	-2.2	-3.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.7	3.1	4.3	-0.7	-2.0	-1.9	-2.1	-1.6	-1.9
High cholesterol (Self-reported)	2.7	4.8	8.5	-1.7	-2.9	-1.3	-2.8	-2.1	-2.0
Average weekly beer plus cider intake	2.7	3.9	7.7	2.8	1.5	1.3	2.0	1.5	2.4
Medication for cholesterol, blood pressure or diabetes	2.3	3.9	11.7	2.1	1.6	0.5	3.4	1.9	0.8
HDL Cholesterol	2.2	3.7	7.6	2.2	2.8	1.6	1.8	1.4	1.5
Lupus	2.0	3.1	8.4	0.6	0.6	2.9	2.5	1.0	1.4
Pain all over the body in last month	2.0	2.1	3.8	-0.8	-0.0	-1.3	-1.8	-2.0	-1.8
Medication: Cholesterol lowering	2.0	3.1	9.0	-1.3	-1.4	-0.8	-3.0	-2.2	-0.5
Medication: Ventolin 100micrograms inhaler	2.0	2.5	5.8	1.7	1.0	1.7	0.6	1.4	2.4
Leg pain on walking	2.0	2.5	8.4	1.6	0.3	0.3	-2.9	-1.0	1.7
Alzheimer’s Disease (including proxy)	1.9	2.8	8.9	-1.5	-3.0	-0.2	-0.4	-0.0	-2.3
Breast Cancer	1.9	4.5	10.8	0.5	2.3	1.7	3.3	1.3	2.4
Rheumatoid Arthritis	1.9	2.6	7.4	2.1	2.7	-0.5	1.3	0.3	1.4
Ever had hysterectomy (womb removed)	1.9	2.1	5.2	-2.3	-0.6	1.8	0.7	1.8	-0.3
Number of full sisters	1.9	2.3	7.2	0.2	-1.2	-0.9	-2.7	-1.9	-0.8
Myopia	1.9	2.8	6.4	1.9	1.7	0.3	-2.5	0.8	1.7
Alcohol drinker status: Previous	1.9	2.1	4.2	1.9	1.9	0.7	-0.8	-0.4	2.1
Major Depression (MDD)	1.8	2.2	7.7	2.8	1.2	0.5	1.0	-0.7	1.5
Tense / ‘highly strung’	1.8	2.9	7.4	-0.2	-2.7	0.4	-2.2	-2.2	-0.6
Loud music exposure frequency	1.8	1.9	3.4	1.2	1.0	1.8	1.4	1.8	0.7
Medication: Seretide 50 evohaler	1.8	2.0	5.7	1.6	1.2	1.3	-0.3	0.8	2.4
Average weekly red wine intake	1.8	2.6	8.4	0.6	1.2	-2.9	-0.2	-1.9	-1.3
Frequency of depressed mood in last 2 weeks	1.7	2.4	8.4	1.6	0.2	2.9	0.0	0.7	1.7
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.7	0.5	1.2	2.2	0.5	1.9	1.4
Number of live births	1.7	2.4	7.5	2.2	0.9	0.8	-0.6	0.4	2.7
Lung cancer (father)	1.7	2.0	4.5	-0.9	-0.6	2.0	2.1	1.3	-0.5
Chronic bronchitis/emphysema (mother)	1.7	1.9	4.2	1.1	2.0	-1.2	-0.6	-1.1	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	6.7	-2.6	-0.9	-2.1	-1.8	-0.8	-2.3
Fed-up feelings	1.6	3.0	6.0	2.4	0.5	2.4	1.0	-0.7	2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	6.0	2.2	2.0	1.7	0.7	1.5	2.4
Risk taking	1.6	2.3	5.8	-2.4	-1.5	0.2	0.2	0.7	-2.4
Crohns Disease (2012)	1.5	2.4	5.0	-1.8	-2.0	-0.3	-0.6	-1.2	-2.2
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.9	-0.5	-1.1	-1.1	-1.6	-2.2	-0.0
Ulcerative Colitis	1.5	2.1	4.6	-1.2	-2.1	-0.4	-1.8	-1.6	-0.9
Type 2 Diabetes (T2D) (2018)	1.5	2.8	9.6	-1.5	-1.6	-0.3	-3.1	-1.2	-0.9
Lung FVC	1.5	7.5	22.5	-2.0	-4.7	0.7	-3.1	-0.4	-2.8
Sensitivity / hurt feelings	1.5	2.5	8.5	0.3	-0.6	-1.6	-1.6	-2.9	-0.8
High blood pressure (mother)	1.5	2.1	5.9	2.4	1.7	0.2	1.5	0.1	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.3	1.7	2.3	-0.2	0.6	-1.3	1.0
Depression (Nagel 2018)	1.4	2.1	9.4	0.2	-0.2	3.1	0.5	1.7	0.6
Alzheimer’s Disease (in mother)	1.4	1.7	6.2	-0.9	-2.5	-0.0	0.0	0.4	-1.7
Noisy workplace	1.4	1.7	5.5	2.0	2.3	-0.4	0.5	-0.2	0.8
Health satisfaction	1.4	1.8	3.2	1.0	1.8	1.7	0.3	1.5	1.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.3	2.3	-0.3	1.6	0.7	0.7	0.9
Diabetes diagnosed by doctor	1.4	2.4	8.6	-1.6	-1.5	0.1	-2.9	-0.5	-0.7
Unable to work because of sickness or disability	1.4	1.9	8.6	0.9	-0.3	2.9	0.2	0.9	0.9
Average weekly spirits intake	1.3	1.6	3.8	-1.5	-0.6	-1.1	-2.0	-0.1	-1.4
Hearing difficulty/problems: Yes	1.3	2.0	4.6	0.7	2.1	1.0	-1.7	0.7	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	5.7	0.8	-0.1	2.4	0.9	1.3	1.2
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	4.1	2.0	0.4	0.8	1.0	-0.2	1.9
Migraine (self-reported)	1.3	1.6	4.4	1.6	1.3	1.0	-0.1	0.1	2.1
Medication: Allopurinol	1.3	1.7	3.5	-1.1	-1.4	-1.2	-1.9	-1.2	-0.7
Age at last live birth	1.3	1.9	4.8	1.4	2.0	-0.6	2.2	0.3	0.7
Illnesses of siblings: Diabetes	1.3	1.6	4.1	-0.0	-1.5	-1.0	-2.0	-1.3	-0.9
Hearing aid user	1.3	1.4	4.5	-0.4	1.0	1.6	0.6	0.3	2.1
Mean Putamen Volume	1.2	1.3	5.3	-2.3	-1.0	0.7	0.4	0.1	-1.1
Supplements: Zinc	1.2	1.4	3.8	1.9	1.6	-0.3	0.1	-0.3	1.3
Taking other prescription medications	1.2	1.8	5.2	-0.5	-1.9	-0.5	-2.3	-0.9	-0.9
Alcohol usually taken with meals	1.2	1.9	5.7	-0.9	0.2	-2.4	0.3	-1.1	-1.8
Medication: Lansoprazole	1.2	1.4	3.6	-0.6	-1.9	1.1	-1.6	-0.8	0.3
Shortness of breath walking on level ground	1.2	1.5	3.8	1.1	-0.0	1.6	-2.0	0.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.5	-0.4	-1.0	-1.2	-1.9	-1.1	-1.1
Mother’s age at death	1.2	1.5	4.6	-2.2	-0.6	-1.3	-0.3	0.2	-1.4
Ever depressed for a whole week	1.2	1.4	3.9	-0.9	0.4	2.0	0.2	1.9	-0.2
Pack years adult smoking proportion	1.1	1.6	4.7	-0.9	-1.7	0.2	-2.2	-1.1	-0.3
Medication: Ramipril	1.1	1.5	3.4	-0.3	-1.2	-0.4	-1.8	-1.8	-0.8
Worry too long after embarrassment	1.1	1.8	8.9	1.2	-0.7	-0.4	-0.1	-3.0	0.0
Pulse wave peak to peak time	1.1	1.3	6.0	0.4	0.3	0.5	2.5	1.0	0.0
Heart disease (mother)	1.1	1.4	5.2	-0.0	-0.4	2.3	1.6	0.5	-0.3
Suffer from ‘nerves’	1.1	1.8	4.7	2.2	0.3	1.3	-1.1	-0.9	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	3.6	1.2	0.7	-0.1	1.9	-1.2	0.1
Number of self-reported non-cancer illnesses	1.1	1.9	4.5	-1.6	-2.1	0.3	-1.3	-1.0	-1.2
Commuting to job workplace: Cycle	1.1	1.3	4.0	2.0	0.8	-1.5	0.0	-1.0	0.1
Ovarian Cancer	1.0	1.3	3.0	-1.7	-1.3	-0.5	0.1	-0.6	-1.6
Respiratory disease	1.0	2.2	3.7	1.8	0.7	1.2	-1.0	1.9	1.9
Medication: Metformin	1.0	1.3	4.0	-0.6	-1.3	-0.1	-2.0	-1.4	0.3
Hearing difficulty/problems with background noise	1.0	1.5	5.4	1.3	2.3	0.0	-0.1	-0.2	1.5
Neuroticism score	1.0	2.0	7.7	1.7	-0.3	0.1	-0.6	-2.8	1.0
Hair/balding pattern: Pattern 3	1.0	1.5	4.4	-0.8	-0.5	-2.1	-0.5	-1.3	-1.4
Happiness	1.0	1.2	4.4	0.2	0.6	1.3	2.1	0.6	-0.5
Pulse wave Arterial Stiffness index	1.0	1.1	5.5	-0.3	-0.1	-0.5	-2.4	-1.0	0.1
Length of working week for main job	1.0	1.1	2.8	-1.7	-0.9	0.4	-1.0	0.4	-1.1
Exposure to tobacco smoke at home	1.0	1.2	2.5	1.2	0.3	-0.4	-1.5	-1.6	0.7
Exposure to tobacco smoke outside home	1.0	1.3	3.5	1.6	-1.2	-0.3	0.5	-1.9	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.1	-1.7	-0.7	1.1	-1.2	1.8	-0.1
Osteoporosis (self-reported)	1.0	1.2	3.1	1.8	0.9	-0.5	-0.5	1.2	1.2
Commuting to job workplace: Public transport	1.0	1.2	3.3	-1.8	1.6	0.2	0.5	0.4	1.0
Pain type(s) experienced in last month: Hip pain	1.0	1.2	4.8	2.2	0.8	-0.4	-0.7	0.4	0.9
Pack years of smoking	1.0	1.5	5.0	-1.0	-1.4	0.1	-2.2	-1.1	0.0
Cardiovascular Disease	0.9	2.9	9.1	-1.1	-1.6	-1.1	-1.8	-3.0	-0.4
Current tobacco smoking	0.9	1.5	3.5	-1.7	-1.5	1.9	-0.2	0.6	0.1
Average weekly fortified wine intake	0.9	1.1	4.4	-0.0	0.5	0.9	2.1	0.9	0.0
Waist circumference	0.9	3.2	6.8	-2.4	-2.6	-0.2	-1.6	-1.0	-1.7
Diabetes (self-reported)	0.9	1.5	3.8	-1.7	-1.2	0.9	-1.9	0.0	-0.2
Medication: Simvastatin	0.9	1.3	4.6	-0.9	-1.1	-0.2	-2.1	-1.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.1	0.6	0.8	1.4	1.4	1.2	0.6
Breastfed as a baby	0.9	1.1	2.4	-1.3	-0.5	0.7	0.5	1.5	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.5	0.0	-1.1	-0.4	-2.1	-0.6	-0.5
Blood clot in the leg (DVT)	0.9	1.2	1.7	-1.1	-1.3	0.2	-1.2	-1.3	-0.9
Age at first live birth	0.9	1.6	4.7	0.3	2.0	-0.8	2.2	0.3	0.4
Medication: Omeprazole	0.9	1.1	2.1	-1.2	-1.3	0.6	-1.5	-0.1	-1.0
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	4.7	0.8	0.5	0.1	2.2	0.9	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.3	-1.2	-1.1	-0.1	-1.3	-1.5	-0.9
Age at First Birth	0.8	1.1	3.5	-0.1	1.9	-0.0	1.5	-0.1	1.0
Lung FEV1/FVC ratio	0.8	3.8	8.5	-0.9	1.6	-2.9	-2.1	-2.6	0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	0.7	0.7	-1.2	-0.6	-1.5	0.4
Vitamin and mineral supplements	0.8	1.1	3.8	-1.1	-0.8	-0.6	-1.9	-0.3	-0.7
Age when periods started (menarche)	0.8	1.9	4.8	0.1	0.2	2.2	-1.1	1.8	1.4
Multivitamins +/- minerals	0.8	1.1	5.0	0.0	-0.2	0.7	2.2	0.8	0.2
Time employed in main current job	0.8	1.0	2.2	1.5	1.3	-1.3	0.2	-0.0	0.4
Alcohol intake versus 10 years previously	0.8	1.1	2.8	0.5	-0.5	1.5	0.7	0.9	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.4	-0.3	0.6	0.5	-2.1	0.0	0.5
Birth weight of first child	0.8	1.4	4.4	0.7	-0.0	-2.1	0.8	-1.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	4.2	0.1	0.7	2.1	0.7	1.3	0.8
Medication: Blood pressure	0.8	1.3	3.2	-1.2	-0.5	-0.5	-1.8	-1.7	-0.3
Medication: Aspirin	0.8	1.1	3.4	0.1	-0.4	-0.0	-1.7	-1.8	0.2
Knee pain experienced in last month	0.8	1.2	3.2	0.8	0.3	1.7	0.7	0.4	1.8
Hypertension (Self-reported)	0.8	2.2	6.8	-1.3	-1.2	-1.3	-0.9	-2.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	4.3	-0.2	-0.6	-0.7	-2.1	-0.7	0.4
Ever had bowel cancer screening	0.8	1.0	2.0	-1.4	-1.1	0.1	-1.4	-0.4	-0.7
Medication: Aspirin	0.8	1.0	3.4	0.1	-0.5	-0.2	-1.5	-1.8	0.1
Guilty feelings	0.8	1.2	3.5	1.3	0.2	0.1	1.9	-1.2	0.6
Irritability	0.8	1.4	5.1	-0.6	-1.0	0.4	-2.2	-1.2	0.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	-1.2	-0.1	1.1	1.3	0.9	-0.7
Fractured/broken bones in last 5 years	0.8	1.0	3.6	-0.5	0.6	-1.9	-1.2	-0.8	-0.1
Worry (Nagel 2018)	0.7	1.4	3.4	0.1	-1.5	-0.1	-1.9	-1.7	-0.4
Crohns Disease (2017)	0.7	1.5	6.0	-1.0	-1.2	0.2	0.9	-0.1	-2.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.0	-1.7	-0.3	0.3	-1.6	0.2	0.1
Chronic bronchitis/emphysema (father)	0.7	0.9	2.6	-0.6	-1.0	1.6	0.4	1.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.3	1.0	-0.4	1.8	-1.1	0.1	1.1
Worrier / anxious feelings	0.7	1.3	4.4	1.3	0.1	-1.0	-0.6	-2.1	-0.4
Pulse rate	0.7	1.3	3.7	-0.4	-0.8	-1.0	-1.9	-1.2	-0.9
Asthma	0.7	1.3	3.4	1.4	0.2	0.5	-0.9	1.1	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.7	0.0	-0.3	-0.8	-1.9	-1.4	-0.7
Medication: Paracetamol	0.7	1.2	3.6	0.5	0.4	1.7	1.9	0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.7	-0.9	-1.6	-0.1	-1.2	-1.4	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.4	1.3	-0.3	1.0	-1.6	0.2	0.1
Pulse rate, automated reading	0.7	2.4	5.4	-1.0	-2.3	-0.1	-2.2	-0.8	-1.6
Eye problems/disorders: Cataract	0.7	0.8	3.0	-0.7	0.4	0.1	1.1	0.1	1.7
Osteoarthritis (self-reported)	0.7	1.0	2.1	1.4	0.3	1.2	-0.2	-0.1	1.5
Medication: Gliclazide	0.7	0.8	3.4	-0.7	-0.8	0.1	-1.8	-0.0	0.1
Wears glasses or contact lenses	0.7	0.8	1.6	0.7	0.7	1.3	-0.2	0.9	1.1
Illnesses of father: High blood pressure	0.7	0.8	1.3	1.1	1.1	-1.1	-0.3	-0.7	0.9
Age started oral contraceptive pill	0.7	0.8	3.4	-1.8	0.4	-0.3	-0.7	0.7	-0.7
Bipolar Disorder (2018)	0.6	0.9	1.8	-0.6	-1.3	1.3	-0.7	0.8	-0.8
Schizophrenia (2018)	0.6	1.2	3.1	1.8	-0.3	1.5	0.6	0.9	0.8
Schizophrenia vs Biploar Disorder	0.6	0.8	2.7	0.5	1.0	-1.6	-0.7	-0.5	-0.5
LDL Cholesterol	0.6	1.0	2.9	0.1	-0.4	1.7	0.9	1.0	0.9
Medication: Co-codamol	0.6	0.7	2.1	-0.8	-0.2	1.4	-1.0	0.0	0.5
Medication: Atenolol	0.6	0.7	2.0	-0.9	-0.5	-0.6	0.3	1.0	-1.4
Had menopause	0.6	0.8	3.0	-1.7	-0.5	0.1	-0.9	0.6	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.5	1.2	-0.3	1.9	-0.2	0.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.2	-0.8	-0.7	-2.3	-1.2	-1.6	-1.5
Pulse wave reflection index	0.6	0.8	1.9	-1.2	0.4	1.4	-0.1	1.0	0.5
Glaucoma (self-reported)	0.6	0.7	1.9	-0.2	0.0	-1.4	1.2	0.2	-0.8
High blood pressure (siblings)	0.6	0.8	3.3	0.2	0.0	-1.0	-0.2	-1.8	0.6
Number of full brothers	0.6	0.7	1.4	-0.9	1.2	0.4	-0.8	0.0	1.0
Eye problems/disorders: None of the above	0.6	0.6	1.7	0.9	-0.1	0.2	-1.3	0.2	-1.1
Neck or shoulder pain in last month	0.6	0.9	2.8	-0.0	-1.6	1.7	0.2	0.1	0.2
Smoking status: Previous	0.6	0.9	2.3	0.7	1.5	-0.5	0.3	0.7	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	0.5	0.1	-1.4	-0.1	-0.9	-0.9
Smoking status: Current	0.6	0.9	2.7	-1.3	-0.8	1.7	-0.2	0.5	0.5
Medication: Bendroflumethiazide	0.6	1.0	2.2	0.5	-1.5	-0.8	-0.1	-1.4	-0.9
Medication: Atorvastatin	0.6	0.7	1.9	0.4	-1.4	-0.4	-0.9	-0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.6	0.2	-1.0	0.4	-1.6	-0.5	-0.4
Heart disease (siblings)	0.6	0.7	1.2	-0.4	-0.1	1.0	-1.1	-0.9	1.0
Bipolar Disorder or Schizophrenia	0.5	1.2	4.0	1.0	-1.1	2.0	-0.0	1.2	0.1
Depressed Affect (Nagel 2018)	0.5	1.0	3.0	0.6	0.7	1.2	0.5	-0.4	1.7
Body Mass Index (BMI) (2010)	0.5	0.7	2.2	0.0	0.4	-1.5	0.3	-1.3	-0.4
Coronary Artery Disease (CAD)	0.5	0.5	0.9	-1.0	-0.7	0.5	-0.4	-0.8	-0.9
HbA1C	0.5	0.6	1.4	1.2	-0.9	0.2	0.6	-0.6	0.5
Blood Platelet Count	0.5	5.9	14.2	-0.4	-1.1	-3.8	0.1	-3.8	-2.4
Blood Red Count	0.5	4.8	12.7	-2.2	-2.4	-0.2	-3.6	-1.5	-1.9
Smoking Status	0.5	1.3	3.0	-1.7	-0.9	1.5	-0.1	1.3	0.3
Medication for hormone replacement therapy	0.5	0.6	2.4	-1.5	-0.6	0.4	-0.2	0.7	-0.4
Diabetes (father)	0.5	0.6	2.3	0.4	0.3	-1.5	-0.5	-0.8	-0.7
Serious illness, injury or assault to yourself	0.5	0.6	1.6	-0.3	0.6	-0.2	-1.2	-0.0	-1.3
High blood pressure	0.5	1.5	6.1	-0.9	-0.6	-1.0	-0.7	-2.5	-0.3
Number of incorrect matches in round	0.5	0.8	2.1	1.3	0.6	-0.0	1.4	-0.7	0.4
Nervous feelings	0.5	1.0	3.6	1.2	-0.9	-0.2	0.1	-1.9	0.4
Qualifications: None of the above	0.5	1.1	3.2	1.8	0.1	0.9	-0.4	0.1	1.5
Mouth/teeth dental problems	0.5	0.7	2.2	0.6	0.3	-0.7	1.5	-1.1	-0.2
Falls in the last year	0.5	0.7	2.2	-0.1	1.4	0.0	-0.3	1.5	0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	3.0	-0.4	-0.2	-0.5	-1.0	0.5	-1.7
Depression (self-reported)	0.5	0.6	1.7	1.3	-0.6	0.7	-0.3	-0.6	0.6
Prospective memory result	0.5	0.6	1.2	0.9	0.3	0.8	-1.1	0.1	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.1	-0.5	-0.6	-2.0	-1.1	-1.5	-1.4
Medication: Ibuprofen	0.5	0.6	1.1	0.3	0.7	0.9	0.7	1.1	0.8
Mood swings	0.5	0.9	2.0	1.4	-0.3	1.0	-0.1	-1.1	1.2
Friendships satisfaction	0.5	0.6	1.6	0.5	-0.7	0.0	-0.7	-1.3	-0.9
Breast cancer (self-reported)	0.5	0.6	2.6	-1.6	0.6	-0.2	-0.0	0.5	-0.5
Asthma (self-reported)	0.5	1.0	2.2	1.2	-0.1	0.2	-1.1	1.0	1.5
Miserableness	0.5	0.8	2.5	0.8	0.3	0.5	0.1	-1.2	1.6
Medication: Paracetamol	0.5	0.8	2.0	0.3	0.2	1.4	1.3	0.6	0.8
Supplements: Calcium	0.5	0.5	1.3	0.5	0.3	-0.1	-0.8	-1.1	1.0
Neuroticism (Nagel 2018)	0.4	0.9	1.8	0.9	0.1	0.9	-0.1	-1.4	1.3
Bipolar Disorder (2011)	0.4	0.4	1.5	0.8	-0.4	1.2	0.3	0.3	0.3
Fasting Glucose	0.4	0.5	1.9	0.2	-0.3	0.8	-0.6	1.4	0.1
Schizophrenia (2014)	0.4	0.8	2.8	1.7	-0.7	0.9	-0.8	0.3	0.3
Triglycerides	0.4	0.7	3.0	-1.0	-1.7	0.2	0.5	-0.3	0.2
Systolic Blood Pressure	0.4	2.2	5.3	1.7	1.1	-1.1	-1.1	-2.3	1.0
Number of treatments/medications taken	0.4	0.8	2.2	-0.3	-1.5	1.3	-0.8	0.3	0.0
Angina	0.4	0.5	2.2	0.3	0.3	0.3	-1.5	-0.6	0.4
Maternal smoking around birth	0.4	0.5	1.2	-0.3	0.3	1.0	-0.7	0.6	1.1
Relative age voice broke	0.4	0.6	1.5	-1.2	1.0	0.2	0.9	-0.2	0.3
Supplements: Glucosamine	0.4	0.6	1.5	0.3	1.2	0.2	0.9	0.7	0.7
Forced vital capacity (FVC)	0.4	1.6	3.1	-1.2	-1.4	-1.4	-0.7	-0.9	-1.8
Father’s age at death	0.4	0.5	2.5	0.1	-0.5	-0.0	-0.3	1.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.3	-0.8	-1.0	1.5	-0.6	-0.1	-1.1
Hair/balding pattern: Pattern 4	0.4	1.1	3.2	-0.7	0.8	-0.2	-1.4	-1.8	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	0.3	0.3	0.6	0.0	0.5	1.4
Headache pain in last month	0.4	0.7	2.2	1.5	0.2	0.7	0.6	0.5	0.9
Gout (self-reported)	0.4	0.5	1.8	-1.3	-0.2	-0.5	-0.8	-0.4	-0.3
Number of children fathered	0.4	0.4	1.2	0.2	0.4	0.5	0.6	1.1	0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.9	-0.1	0.5	-0.5	-1.2	0.5
Emphysema/chronic bronchitis	0.4	0.5	1.1	1.0	-0.7	0.0	-0.3	-0.8	-0.8
Angina (self-reported)	0.4	0.5	2.4	0.5	0.1	0.2	-1.6	-0.6	0.3
Alcohol intake frequency.	0.4	0.9	1.9	0.6	0.3	1.3	-0.5	0.9	1.4
Chest pain or discomfort	0.4	0.6	2.1	-0.5	-1.5	-0.0	-1.1	0.1	-0.2
Average weekly champagne plus white wine intake	0.4	0.6	1.3	0.1	-0.3	0.4	1.1	-1.2	0.7
Ever taken oral contraceptive pill	0.4	0.4	1.1	-0.2	0.5	1.0	-0.0	0.9	0.7
Financial situation satisfaction	0.4	0.4	1.0	1.0	0.6	0.9	0.7	0.0	-0.2
Leg fat percentage (left)	0.4	1.4	3.2	-1.2	-1.8	0.0	-1.3	-1.1	-1.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	5.0	0.5	0.3	0.5	1.1	2.2	-0.1
Irritable Bowel Disease (IBD)	0.3	0.8	2.1	-0.3	-1.1	0.1	0.5	-0.9	-1.5
Reaction Time	0.3	0.5	1.4	0.7	-0.6	0.6	1.2	-0.4	0.6
Blood Eosinophil Count	0.3	2.1	11.4	3.4	0.5	0.1	-0.0	0.3	1.0
Allergy or Eczema	0.3	0.9	2.0	-0.2	0.2	-0.2	-1.2	1.4	1.2
Hypothyroidism (self reported)	0.3	0.8	1.4	-1.2	-1.0	-0.5	-0.7	-0.6	-1.0
Relative age of first facial hair	0.3	0.6	1.7	-0.6	1.3	0.5	1.1	0.1	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.3	-0.7	0.0	0.6	-1.0	-0.9
Trunk fat percentage	0.3	1.1	2.6	-1.6	-1.5	-0.2	-0.3	-0.6	-1.0
Hand grip strength (right)	0.3	0.8	3.8	0.2	0.0	-0.7	1.9	-0.4	-0.2
Townsend deprivation index at recruitment	0.3	0.4	1.2	0.7	-1.1	0.4	0.5	-0.5	0.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.5	-1.2	-0.4	0.7	-0.2	-0.1	0.1
Qualifications: CSEs or equivalent	0.3	0.3	1.4	0.5	1.2	0.0	-0.3	0.3	0.5
Medication: Levothyroxine sodium	0.3	0.4	1.0	-0.1	-0.9	0.7	-1.0	-0.6	0.1
Past tobacco smoking	0.3	0.5	1.5	-0.1	-1.2	0.2	0.1	-0.6	-1.0
Had other major operations	0.3	0.4	1.2	-0.5	-1.1	0.6	-0.7	0.4	0.1
Allergy	0.3	0.8	3.5	-0.2	0.9	0.4	1.9	0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	-0.4	-1.2	-0.2	-0.7	-0.2	-0.4
Peak expiratory flow (PEF)	0.3	0.6	1.8	-0.6	-0.3	-1.4	-0.5	-0.9	-0.7
Body fat percentage	0.3	1.2	3.0	-1.5	-1.7	-0.1	-0.5	-0.9	-1.0
Leg fat percentage (right)	0.3	1.0	2.8	-0.9	-1.7	0.3	-1.1	-0.9	-0.7
Comparative body size at age 10	0.3	0.8	2.0	-0.3	0.7	-0.9	1.4	-1.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	0.4	0.6	0.7	0.3	0.8	0.6
Qualifications: College or University degree	0.3	0.8	2.0	-1.4	-0.2	-0.1	-0.4	0.8	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.9	0.5	0.7	-1.4	0.9	0.3	0.1
Overall health rating	0.3	0.7	2.1	0.3	-1.3	1.4	-0.4	-0.5	0.3
Had major operations	0.3	0.3	1.4	-0.5	0.1	0.3	1.2	0.2	-0.2
Family relationship satisfaction	0.3	0.4	1.4	1.2	0.1	-0.1	0.0	-0.9	0.1
Loneliness, isolation	0.3	0.4	1.2	0.8	0.1	0.1	1.1	-0.7	0.2
Back pain experienced in last month	0.3	0.4	1.0	0.6	-0.5	-0.7	-0.0	-1.0	0.5
Mineral and other dietary supplements	0.3	0.4	0.9	-1.0	-0.6	0.6	-0.2	0.3	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	0.1	-0.3	-0.4	1.1	0.2	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	0.9	-0.1	1.0	-0.5	0.3	0.4
Medication: Lisinopril	0.3	0.4	1.2	-0.6	-0.4	-0.3	0.2	-1.1	0.5
Alcohol drinker status: Never	0.3	0.3	1.2	0.3	1.1	0.0	0.2	0.1	0.7
Cholesterol lowering medication	0.3	0.5	2.3	-0.1	-1.5	0.7	-0.4	-0.0	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.4	-0.6	0.6	-0.2	0.3	-0.0
Ulcerative Colitis (UC)	0.2	0.4	1.3	0.3	-0.5	0.5	-0.4	-1.1	0.1
Neuroticism (2016)	0.2	0.3	1.4	1.2	-0.2	-0.2	0.3	-0.5	-0.2
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.0	0.7	0.2	-0.7	0.5	-0.1
Neuroticism	0.2	0.4	1.1	0.7	0.2	0.4	-0.0	-1.0	0.8
Chronotype (morning person)	0.2	0.6	1.9	-0.9	0.8	-1.4	-0.0	-0.1	-0.2
Hand grip strength (left)	0.2	0.5	2.6	0.2	-0.2	-0.5	1.6	0.6	-0.2
Systolic blood pressure, automated reading	0.2	0.7	1.6	0.5	0.4	-0.5	-1.2	-1.2	0.6
Diabetes (mother)	0.2	0.2	0.7	0.6	0.4	0.3	0.1	-0.8	0.2
Leg fat-free mass (left)	0.2	1.1	2.8	0.5	1.4	-0.1	1.7	0.6	1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.4	0.7	-0.2	0.8	-0.0	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	-0.1	-0.2	-1.1	-1.0	-0.1	0.3
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.7	-0.3	0.7	0.6	-0.4	-0.1
Sitting height	0.2	1.5	3.5	-1.2	1.9	-0.4	1.9	0.5	0.2
Impedance of leg (left)	0.2	0.9	2.0	-1.4	-0.9	-0.1	-1.0	-0.1	-1.4
Leg predicted mass (left)	0.2	1.1	2.6	0.5	1.4	-0.1	1.6	0.5	1.2
Trunk fat mass	0.2	0.7	2.5	-1.6	-1.2	-0.0	0.2	-0.2	-0.7
Financial difficulties in last 2 years	0.2	0.3	0.9	0.2	-0.8	0.4	1.0	0.3	-0.2
Heart attack	0.2	0.2	0.5	0.3	-0.2	0.7	-0.5	-0.5	0.5
Illnesses of siblings	0.2	0.2	1.0	0.2	0.2	0.3	0.4	1.0	-0.2
Impedance of arm (right)	0.2	0.8	1.6	-0.3	1.1	-0.6	1.1	1.3	-0.0
Trunk fat-free mass	0.2	1.0	4.0	0.1	1.2	0.1	2.0	0.5	0.7
Hip circumference	0.2	0.8	2.7	-1.0	0.8	-0.7	1.6	-0.2	-0.3
Illnesses of mother	0.2	0.3	0.8	-0.4	-0.5	-0.1	-0.9	0.2	-0.6
Trunk predicted mass	0.2	1.0	3.9	0.1	1.2	0.1	2.0	0.5	0.7
Standing height	0.2	2.5	6.4	-1.1	2.0	-0.4	2.5	1.7	0.5
Medication: Amlodipine	0.2	0.2	1.0	1.0	0.4	0.3	0.1	0.0	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	0.9	0.5	0.4	0.2	0.5	0.2
Whole body fat mass	0.2	0.7	2.1	-1.4	-1.3	-0.0	0.1	-0.5	-0.7
Supplements: Vitamin C	0.2	0.2	0.9	0.0	-0.1	0.9	0.1	0.6	0.1
Illnesses of father: Heart disease	0.2	0.3	0.5	0.5	0.7	0.4	-0.6	-0.1	0.7
Whole body fat-free mass	0.2	0.9	3.5	0.2	1.2	0.0	1.9	0.4	0.8
Leg fat-free mass (right)	0.2	1.0	2.8	0.2	1.3	-0.4	1.7	0.4	1.0
Long-standing illness, disability or infirmity	0.2	0.2	1.0	-0.0	-1.0	-0.0	-0.1	-0.5	-0.4
Qualifications: nursing, teaching	0.2	0.4	1.0	-0.6	-0.5	0.5	1.0	0.6	0.2
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	0.5	-0.6	-0.7	0.3	0.0
Medication for cholesterol	0.2	0.3	1.0	-1.0	0.4	-0.8	-0.3	0.2	-0.3
Whole body water mass	0.2	1.0	3.8	0.2	1.2	0.1	1.9	0.4	0.9
Leg predicted mass (right)	0.2	1.0	3.1	0.2	1.3	-0.4	1.8	0.4	1.0
Eye problems/disorders: Glaucoma	0.2	0.2	1.0	-0.2	-0.2	-0.5	1.0	0.1	-0.3
Medication: Blood pressure	0.2	0.5	1.5	0.5	-0.6	0.2	1.2	-0.8	0.1
Number of operations (self-reported)	0.2	0.4	1.4	-0.1	-0.7	-0.0	0.4	-1.2	-0.4
Pain experienced in last month	0.2	0.4	1.0	-1.0	0.2	-0.6	0.3	0.2	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	0.3	-0.3	0.4	-0.4	-0.8	0.3
Leg fat mass (left)	0.2	0.7	1.7	-1.1	-1.3	0.0	-0.5	-0.6	-0.8
Blood White Count	0.1	0.6	1.6	1.3	-0.7	0.5	-0.8	-0.8	0.3
BMI	0.1	0.4	0.8	-0.5	-0.8	-0.3	0.9	-0.4	-0.7
Height	0.1	2.0	6.5	-2.5	0.6	-0.3	1.6	1.4	-0.9
Tanning	0.1	0.8	1.9	0.9	-0.1	1.4	0.8	0.9	0.6
Severe depression (siblings)	0.1	0.1	0.2	-0.1	-0.3	0.3	-0.4	-0.4	0.3
Impedance of leg (right)	0.1	0.3	0.4	-0.6	-0.5	0.5	-0.7	0.4	-0.6
Body mass index (BMI)	0.1	0.4	1.2	-0.5	-1.1	0.2	-0.0	-0.9	-0.4
Weight	0.1	0.3	1.0	-0.9	-0.2	-0.1	1.0	-0.2	-0.2
Arm fat percentage (right)	0.1	0.5	1.4	-0.8	-1.2	-0.1	0.3	-0.6	-0.6
Impedance of arm (left)	0.1	0.5	1.7	-0.4	0.9	-0.4	0.6	1.3	-0.0
Arm fat mass (right)	0.1	0.4	0.7	-0.8	-0.7	-0.3	0.4	-0.7	-0.6
Birth weight	0.1	0.3	0.6	-0.0	0.7	0.3	0.6	0.8	0.6
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-0.5	-0.9	-0.5	-0.1	-0.1	-0.8
Arm fat-free mass (right)	0.1	0.3	1.2	-0.3	0.4	0.3	1.1	0.3	0.4
Mean time to correctly identify matches	0.1	0.3	1.3	-0.6	-1.1	0.2	-0.1	0.0	-0.1
Leg fat mass (right)	0.1	0.5	1.4	-0.8	-1.2	0.1	-0.4	-0.5	-0.5
Arm predicted mass (right)	0.1	0.4	1.7	-0.3	0.4	0.4	1.3	0.1	0.4
Comparative height size at age 10	0.1	0.5	2.1	-0.5	0.0	-1.4	0.3	0.3	-0.9
Arm fat percentage (left)	0.1	0.5	1.7	-1.0	-1.3	-0.0	0.1	-0.6	-0.5
Arm fat mass (left)	0.1	0.3	0.6	-0.8	-0.8	-0.1	0.4	-0.4	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.1	0.4	0.5	0.0	0.4	-0.3
Ever smoked	0.1	0.2	0.8	-0.9	0.1	-0.5	-0.1	0.2	-0.2
Basal metabolic rate	0.1	0.6	2.8	-0.1	0.8	-0.0	1.7	0.2	0.6
Arm fat-free mass (left)	0.1	0.4	2.1	-0.2	0.6	-0.0	1.4	0.0	0.3
Diastolic blood pressure, automated reading	0.1	0.3	1.5	0.1	0.0	1.2	0.3	-0.3	-0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	-0.3
Arm predicted mass (left)	0.1	0.3	1.4	-0.2	0.3	0.1	1.2	-0.1	0.0
Hair Pigment	0.0	1.1	2.9	-0.6	0.1	0.3	-1.7	-1.6	-0.6
Impedance of whole body	0.0	0.2	0.6	-0.7	0.2	0.1	0.0	0.8	-0.5

Hub : Genes

TRAM1

Models

Trait associations