Best TWAS P=2.05e-14 · Best GWAS P=3.94e-25 conditioned to 0.0222
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | ASAP1 | 0.08 | 0.04 | blup | 714 | 0.04 | 2.8e-06 | 3.3 | 5.8 | 5.9e-09 | 0.26 | 0.92 | 0.03 | TRUE |
| 2 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GSDMC | 0.03 | 0.01 | blup | 57 | 0.02 | 1.4e-02 | 6.3 | 5.5 | 4.1e-08 | 0.48 | 0.07 | 0.06 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GSDMC | 0.05 | 0.06 | lasso | 7 | 0.05 | 1.5e-10 | 6.3 | 6.6 | 3.6e-11 | 0.66 | 0.87 | 0.13 | TRUE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GSDMC | 0.21 | 0.14 | blup | 57 | 0.15 | 1.2e-07 | 6.8 | 7.7 | 2.1e-14 | 0.74 | 0.28 | 0.68 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GSDMC | 0.25 | 0.30 | lasso | 5 | 0.32 | 4.6e-36 | 6.3 | 6.1 | 1.3e-09 | 0.57 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GSDMC | 0.16 | 0.14 | blup | 57 | 0.15 | 6.3e-17 | 5.4 | 5.8 | 5.0e-09 | 0.47 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GSDMC | 0.03 | 0.02 | blup | 57 | 0.02 | 1.4e-03 | 6.3 | 7.2 | 4.5e-13 | 0.65 | 0.04 | 0.65 | FALSE |