Best TWAS P=1.9e-14 · Best GWAS P=2.27e-21 conditioned to 2.55e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK9 | 0.05 | 0.07 | lasso | 1 | 0.06 | 1.1e-07 | 6.90 | 6.9 | 5.1e-12 | 0.47 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FAM129B | 0.11 | 0.03 | enet | 23 | 0.05 | 1.8e-06 | 8.89 | -5.2 | 1.8e-07 | -0.59 | 0.01 | 0.98 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | TOR2A | 0.03 | 0.00 | blup | 372 | 0.00 | 8.1e-02 | 3.14 | -7.7 | 1.9e-14 | -0.55 | 0.12 | 0.05 | TRUE |
| 4 | GTEx | Artery Aorta | FPGS | 0.08 | 0.10 | lasso | 3 | 0.08 | 3.8e-05 | 6.71 | -6.5 | 7.4e-11 | -0.45 | 0.42 | 0.05 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | FPGS | 0.10 | 0.03 | enet | 8 | 0.08 | 1.4e-06 | 5.99 | -6.8 | 9.7e-12 | -0.49 | 0.89 | 0.01 | FALSE |
| 6 | GTEx | Heart Left Ventricle | GARNL3 | 0.11 | 0.02 | lasso | 5 | 0.02 | 4.5e-02 | 5.28 | -5.6 | 1.8e-08 | -0.31 | 0.13 | 0.04 | FALSE |
| 7 | GTEx | Liver | SLC2A8 | 0.18 | 0.00 | lasso | 8 | -0.01 | 5.0e-01 | 5.28 | 5.2 | 1.7e-07 | 0.39 | 0.06 | 0.16 | FALSE |
| 8 | GTEx | Lung | FPGS | 0.08 | 0.04 | enet | 7 | 0.04 | 4.5e-04 | 6.71 | -6.1 | 8.6e-10 | -0.39 | 0.66 | 0.14 | FALSE |
| 9 | GTEx | Nerve Tibial | FPGS | 0.09 | 0.07 | enet | 14 | 0.06 | 2.6e-05 | 6.71 | -6.4 | 1.7e-10 | -0.41 | 0.69 | 0.07 | FALSE |
| 10 | GTEx | Pancreas | FPGS | 0.09 | 0.06 | lasso | 4 | 0.04 | 1.1e-02 | -6.34 | -6.5 | 1.0e-10 | -0.40 | 0.18 | 0.13 | FALSE |
| 11 | GTEx | Prostate | STXBP1 | 0.39 | -0.01 | enet | 9 | 0.02 | 1.2e-01 | 4.54 | 5.6 | 1.7e-08 | 0.45 | 0.05 | 0.15 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | CDK9 | 0.07 | 0.05 | lasso | 2 | 0.04 | 3.6e-04 | 6.81 | -6.7 | 1.9e-11 | -0.45 | 0.65 | 0.08 | FALSE |
| 13 | GTEx | Whole Blood | RP11-339B21.14 | 0.13 | 0.00 | enet | 19 | 0.04 | 6.2e-05 | -0.43 | -5.4 | 6.2e-08 | -0.12 | 0.05 | 0.03 | TRUE |
| 14 | YFS | Blood | CDK9 | 0.03 | 0.01 | blup | 375 | 0.02 | 8.0e-08 | 6.90 | 6.8 | 9.1e-12 | 0.28 | 0.77 | 0.18 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SH2D3C | 0.02 | 0.02 | lasso | 2 | 0.03 | 2.5e-06 | 5.52 | -6.5 | 1.2e-10 | -0.49 | 0.03 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CDK9 | 0.02 | 0.01 | blup | 43 | 0.02 | 4.6e-03 | 5.99 | 6.7 | 2.9e-11 | 0.50 | 0.02 | 0.52 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FPGS | 0.02 | 0.01 | enet | 3 | 0.02 | 1.9e-03 | -6.15 | -6.5 | 6.0e-11 | -0.44 | 0.03 | 0.61 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SH2D3C | 0.07 | 0.03 | blup | 60 | 0.04 | 3.6e-03 | -6.44 | -7.2 | 7.6e-13 | -0.48 | 0.02 | 0.92 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDK9 | 0.02 | 0.01 | blup | 43 | 0.02 | 3.6e-03 | 5.52 | 7.3 | 3.4e-13 | 0.46 | 0.02 | 0.69 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | FPGS | 0.05 | 0.01 | blup | 48 | 0.02 | 7.7e-03 | 6.71 | -6.2 | 6.9e-10 | -0.39 | 0.02 | 0.50 | FALSE |