Hub : Genes

CDK9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0530 0.0220 1.0e-03 0.067 0.021 0.047 0.033 0.059 1.4e-08 1.2e-03 2.1e-06 5.4e-05 1.1e-07
2 GTEx Skin Sun Exposed Lower leg 0.0660 0.0290 3.9e-03 0.046 NA 0.032 NA 0.039 1.0e-04 NA 1.1e-03 NA 3.6e-04
3 GTEx Uterus 0.4580 0.1240 3.3e-03 -0.006 NA -0.015 NA -0.014 4.4e-01 NA 9.4e-01 NA 7.8e-01
4 YFS Blood 0.0328 0.0117 2.8e-05 0.009 0.022 0.017 0.021 0.016 5.3e-04 8.0e-08 1.6e-06 1.1e-07 3.2e-06
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0195 0.0115 7.4e-03 0.012 0.017 0.007 NA 0.012 1.4e-02 4.7e-03 5.3e-02 NA 1.4e-02
6 TCGA Prostate Adenocarcinoma 0.0157 0.0095 9.9e-03 0.014 0.019 0.012 NA 0.015 1.1e-02 3.6e-03 1.9e-02 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.2 1.8 4.6 0.9 -1.0 -1.5 2.1 0.9 1.2
Bipolar Disorder or Schizophrenia 1.0 2.5 4.5 1.7 -1.7 -0.5 1.4 1.7 2.1
Depressed Affect (Nagel 2018) 1.2 2.6 5.0 -1.8 1.8 0.2 0.5 -2.2 -2.0
Depression (Nagel 2018) 0.0 0.1 0.3 0.1 -0.0 -0.5 0.2 0.2 0.2
Intelligence (Savage-Jansen 2018) 1.6 4.9 8.1 -2.0 1.9 1.5 -2.0 -2.8 -2.9
Neuroticism (Nagel 2018) 0.4 0.8 2.2 -0.4 0.4 0.1 1.4 -1.5 -0.7
Schizophrenia (2018) 0.8 1.6 3.2 1.4 -1.3 0.6 0.1 1.4 1.8
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 0.8 -1.0 -0.0 0.1 0.3 0.7
Worry (Nagel 2018) 0.3 0.6 1.7 -0.2 0.1 -0.9 1.3 -1.0 -0.1
Alzheimer’s Disease (in mother) 0.4 0.4 0.8 0.6 -0.5 0.1 0.6 0.9 0.9
Alzheimer’s Disease (in father) 0.5 0.5 1.7 0.6 -0.6 -1.3 -0.7 0.5 0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 0.7 -0.6 -0.3 -0.1 0.8 0.8
Crohns Disease (2017) 1.5 3.3 8.2 -1.6 1.7 -0.9 -0.7 -2.3 -2.9
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 0.8 -0.8 -1.0 0.8 0.4 0.2
Ulcerative Colitis (UC) 2.1 3.9 5.7 2.2 -2.3 -0.8 1.6 2.2 2.4
Major Depression (MDD) 0.5 0.6 3.1 -0.3 0.3 1.8 0.6 0.0 0.0
Reaction Time 0.9 1.7 2.9 1.5 -1.5 0.1 0.2 1.7 1.7
Verbal and Numeric Reasoning (VNR) 0.8 1.8 3.6 -1.4 1.3 -0.6 -0.6 -1.9 -1.8
Breast Cancer 0.5 1.2 2.3 -1.4 1.5 1.0 -0.5 -0.8 -0.9
Ovarian Cancer 0.4 0.5 0.8 -0.6 0.4 0.6 -0.9 -0.8 -0.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.3 1.9 2.6 -0.8 0.7 1.6 -1.6 -1.6 -1.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.2 1.7 6.0 0.6 -0.5 -1.7 2.5 0.5 0.6
Coronary Artery Disease (CAD) 0.5 0.5 1.0 -0.4 0.7 -0.9 0.4 -1.0 -0.8
Crohns Disease (2012) 1.1 1.9 3.8 -0.7 0.7 -1.9 0.5 -1.5 -2.0
Mean Putamen Volume 1.1 1.3 2.7 1.2 -1.2 0.1 1.6 1.1 0.8
Fasting Glucose 0.6 0.8 3.3 -0.0 -0.0 -1.8 0.8 0.6 0.4
HbA1C 3.5 3.9 5.3 2.2 -2.3 -1.2 1.9 2.1 2.0
HDL Cholesterol 1.0 1.7 3.0 1.4 -1.3 1.2 0.5 1.3 1.7
LDL Cholesterol 0.7 1.2 5.4 -0.2 -0.3 -2.3 0.1 1.1 0.4
Lupus 2.3 3.5 6.1 -2.3 2.2 0.4 -1.7 -1.3 -2.5
Neuroticism (2016) 2.2 3.2 4.9 2.1 -2.2 -0.4 2.2 1.3 1.8
Primary Biliary Cirrhosis 0.1 0.2 0.4 -0.2 0.2 -0.0 0.4 -0.6 -0.6
Rheumatoid Arthritis 0.4 0.5 0.9 0.8 -0.9 0.9 1.0 -0.2 0.3
Schizophrenia (2014) 0.5 1.2 3.2 0.9 -1.0 0.9 0.1 1.1 1.8
Triglycerides 0.6 1.0 2.6 -1.0 1.2 -1.6 0.2 -0.4 -1.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.7 -0.1 0.0 0.1 0.6 0.8 0.6
Ulcerative Colitis 1.9 2.7 3.2 1.6 -1.7 -1.7 1.5 1.6 1.8
Blood Eosinophil Count 1.1 8.5 13.9 -2.8 2.5 3.2 -1.2 -3.3 -3.7
Blood Platelet Count 0.1 0.9 1.4 -1.1 1.2 -1.0 -1.1 0.8 0.2
Blood Red Count 0.2 2.2 6.6 0.2 -0.4 2.2 2.6 0.5 1.0
Blood White Count 0.5 3.3 7.9 1.6 -1.6 1.5 0.2 2.8 2.2
Heel T-Score 5.4 43.2 53.0 6.9 -6.7 -4.8 6.8 6.7 7.3
BMI 1.1 6.1 15.2 2.1 -2.1 -1.2 3.9 2.6 2.1
Height 0.4 7.9 19.5 -1.5 1.5 4.4 -3.0 -2.8 -2.6
Waist Hip Ratio (WHR) 0.2 1.0 2.5 -1.2 1.1 0.2 0.0 -1.6 -0.8
Systolic Blood Pressure 0.6 2.9 7.0 0.4 -0.3 -0.6 2.2 2.6 2.2
Smoking Status 0.4 0.9 3.8 0.3 -0.5 2.0 0.7 0.4 0.7
Allergy or Eczema 0.6 1.5 2.7 1.7 -1.6 -0.4 0.4 1.7 0.9
Cardiovascular Disease 2.5 8.4 15.8 1.9 -1.8 -2.5 4.0 3.2 3.3
Hypothyroidism (self reported) 0.5 1.1 2.0 1.0 -1.1 0.6 1.2 1.4 0.9
Respiratory disease 2.2 4.9 7.1 2.1 -2.0 -2.2 2.7 2.1 2.2
Type 2 Diabetes (T2D) (2018) 2.2 4.0 6.4 1.6 -1.5 -1.3 2.5 2.5 2.3
Lung FEV1/FVC ratio 0.1 0.5 0.9 -0.9 0.8 0.4 0.5 -0.9 -0.5
Lung FVC 0.1 0.5 1.1 -0.9 1.0 0.6 0.6 -0.8 -0.3
Neuroticism 0.6 1.4 3.7 -0.7 0.8 0.2 1.9 -1.6 -1.1
Chronotype (morning person) 1.5 3.4 14.1 0.9 -1.0 -3.8 1.7 1.0 0.7
Hair Pigment 0.1 2.7 4.5 2.1 -2.0 -0.6 0.7 1.5 2.1
Tanning 0.0 0.5 2.2 0.2 -0.2 -1.5 0.3 0.5 0.1
Hand grip strength (left) 1.2 3.2 5.0 2.2 -2.2 0.7 0.4 2.0 2.2
Number of treatments/medications taken 0.4 0.7 3.6 0.3 -0.4 -0.2 1.9 0.3 0.3
Average weekly spirits intake 1.6 2.0 3.5 -1.2 1.5 1.1 -1.2 -1.4 -1.9
Sensitivity / hurt feelings 1.2 2.1 5.0 -1.0 1.1 2.2 -0.4 -1.8 -1.5
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.2 0.1 -0.1 -0.3 0.2 0.4 0.2
Hearing difficulty/problems: Yes 1.3 2.0 5.4 -0.8 0.9 2.3 -0.6 -1.5 -1.6
Relative age of first facial hair 0.5 1.1 2.2 -0.9 0.6 0.8 -1.0 -1.2 -1.5
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 1.0 -0.1 -0.2 0.0 1.0 0.0 0.3
Ever used hormone-replacement therapy (HRT) 1.9 2.4 4.5 -1.6 1.5 0.8 -2.1 -1.4 -1.7
Ever had hysterectomy (womb removed) 0.9 1.0 3.0 0.9 -0.9 -0.9 1.7 0.3 0.9
Systolic blood pressure, automated reading 1.4 4.0 9.5 1.4 -1.4 -0.9 1.4 3.1 2.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.6 0.4 -0.4 -1.1 1.6 0.4 0.8
Angina 0.8 1.0 4.0 0.4 -0.3 -1.1 2.0 0.7 0.4
Medication for hormone replacement therapy 1.7 1.8 2.9 1.7 -1.6 0.3 0.4 1.7 1.6
Vitamin and mineral supplements 0.4 0.6 1.3 -1.1 1.1 -0.3 -0.2 -0.5 -0.9
Supplements: Zinc 0.1 0.2 0.4 0.6 -0.6 -0.2 0.0 0.0 0.3
Medication: Co-codamol 0.2 0.2 0.6 0.0 0.1 -0.0 0.3 -0.8 -0.6
Medication: Metformin 2.6 3.7 6.1 1.9 -2.0 -0.8 2.5 1.7 2.2
Diabetes (father) 2.7 3.4 6.0 2.5 -2.3 -0.1 1.7 1.9 1.7
Diabetes (mother) 3.0 3.9 6.7 1.7 -1.9 -0.6 2.6 2.3 2.1
Severe depression (siblings) 0.2 0.2 0.8 -0.2 0.2 -0.5 -0.4 -0.3 -0.9
Pack years adult smoking proportion 0.2 0.3 0.7 0.3 -0.3 0.8 0.4 0.2 0.7
Impedance of leg (right) 0.6 2.9 5.2 -1.8 1.7 2.3 -1.8 -1.5 -0.8
Leg fat-free mass (left) 0.2 0.9 3.1 0.7 -0.7 -0.8 1.8 0.7 0.5
Trunk fat percentage 0.1 0.4 1.1 -0.6 0.7 0.1 1.1 0.0 -0.4
Hand grip strength (right) 0.5 1.4 2.9 1.6 -1.7 0.4 0.4 1.1 1.2
Townsend deprivation index at recruitment 2.7 3.8 5.3 -2.1 2.0 2.3 -1.7 -1.8 -1.8
Current tobacco smoking 1.2 2.0 3.3 -1.6 1.6 1.8 -0.7 -1.4 -1.0
Average weekly fortified wine intake 0.4 0.5 2.3 0.5 -0.5 0.3 1.5 -0.3 0.1
Maternal smoking around birth 0.7 1.0 3.0 0.3 -0.1 1.2 -1.7 0.9 0.9
Fed-up feelings 0.3 0.5 0.9 -0.4 0.5 -1.0 0.7 -0.8 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.5 1.1 -1.1 -0.1 1.1 0.9 1.2
Relative age voice broke 0.3 0.5 0.8 -0.8 0.7 -0.6 -0.6 -0.6 -0.9
Taking other prescription medications 0.1 0.1 0.3 0.4 -0.4 -0.2 0.4 -0.0 -0.6
Age when periods started (menarche) 1.7 4.0 6.4 -1.8 1.8 2.5 -1.9 -2.0 -1.8
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 6.7 0.8 -0.8 -2.6 0.8 0.5 0.7
Heel bone mineral density (BMD) T-score, automated (left) 6.3 14.2 21.0 3.2 -3.3 -2.5 4.1 4.5 4.6
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.1 -1.0 1.1 -0.9 -0.0 -0.5 -1.1
Qualifications: CSEs or equivalent 0.9 1.2 2.7 0.9 -0.8 -1.0 1.6 0.9 1.2
Serious illness, injury or assault to yourself 3.4 4.2 6.2 -2.5 2.4 0.2 -1.3 -2.3 -2.4
High blood pressure 1.6 4.4 6.8 1.2 -1.3 -2.1 2.6 2.6 2.3
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.9 1.7 -1.7 -0.5 0.4 1.2 1.2
Multivitamins +/- minerals 0.1 0.1 0.3 0.1 -0.1 -0.5 -0.4 -0.2 0.0
Stomach or abdominal pain in last month 0.3 0.4 0.8 0.9 -0.6 0.0 0.9 0.4 0.0
Supplements: Glucosamine 2.9 3.8 6.3 2.2 -2.2 0.1 1.3 2.5 2.3
Diverticular disease/diverticulitis (self-reported) 3.3 3.9 6.0 2.5 -2.3 0.1 2.3 1.6 2.0
Medication: Atenolol 0.9 1.1 2.2 0.6 -0.5 -1.5 1.2 1.1 1.0
Medication: Levothyroxine sodium 0.8 1.4 1.9 1.4 -1.3 -1.4 1.4 0.8 0.4
Sitting height 0.0 0.2 0.6 0.2 -0.2 0.8 0.5 -0.2 0.7
Chronic bronchitis/emphysema (father) 0.3 0.4 0.8 0.6 -0.5 0.6 0.2 0.9 0.7
High blood pressure (mother) 0.3 0.4 1.1 0.0 -0.2 1.1 0.3 0.9 0.5
Body mass index (BMI) 0.5 1.9 4.9 1.0 -1.0 -0.2 2.2 1.7 1.3
Impedance of leg (left) 0.3 1.7 2.9 -1.2 1.2 1.7 -1.6 -1.2 -0.5
Leg predicted mass (left) 0.2 0.8 3.1 0.7 -0.6 -0.8 1.8 0.6 0.4
Trunk fat mass 0.1 0.4 1.8 -0.3 0.4 0.1 1.3 0.3 -0.1
Waist circumference 0.3 1.1 4.2 0.6 -0.7 -0.0 2.0 0.9 0.9
Number of incorrect matches in round 1.5 2.5 3.7 1.9 -1.7 1.4 1.5 1.2 1.6
Past tobacco smoking 0.3 0.5 2.6 -0.1 0.1 -1.6 0.2 -0.4 -0.3
Alcohol usually taken with meals 0.7 1.2 1.8 -1.2 1.2 0.1 -1.3 -0.9 -1.2
Nervous feelings 0.4 0.7 2.0 -0.0 -0.1 -1.4 1.3 -0.8 -0.0
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.0 -0.7 0.8 1.0 -0.1 -2.0 -1.5
Hearing difficulty/problems with background noise 2.3 3.7 5.9 2.2 -2.1 2.4 1.5 1.6 1.5
Hair/balding pattern: Pattern 2 1.2 1.5 3.9 -0.8 0.8 1.4 -0.6 -2.0 -1.4
Had menopause 0.1 0.1 0.2 -0.4 0.4 -0.4 -0.5 -0.0 -0.0
Had other major operations 4.6 5.6 9.9 -2.5 2.3 2.0 -0.8 -3.1 -2.8
Forced vital capacity (FVC) 0.1 0.3 0.7 -0.6 0.9 -0.7 0.2 -0.3 0.1
Heel bone mineral density (BMD) T-score, automated (right) 6.8 15.7 23.4 3.6 -3.7 -2.8 3.8 4.8 4.6
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.3 -1.1 1.0 0.4 0.2 -0.9 -1.0
Qualifications: None of the above 2.6 5.7 8.7 2.4 -2.5 -0.7 2.7 2.4 2.9
Financial difficulties in last 2 years 0.5 0.6 2.6 -0.6 0.5 0.8 1.6 -0.3 0.2
Mouth/teeth dental problems 1.0 1.5 2.4 1.1 -1.2 -0.2 1.5 1.3 1.5
Heart attack 0.5 0.6 1.7 0.6 -0.6 0.1 1.3 1.0 0.7
Allergy 2.9 6.6 8.3 -2.9 2.8 1.6 -2.2 -2.8 -2.9
Pain all over the body in last month 1.7 1.8 3.1 -1.8 1.6 -1.1 -0.1 -1.3 -1.4
Diabetes (self-reported) 1.9 3.0 4.0 1.3 -1.2 -1.9 2.0 1.9 1.8
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 5.9 0.7 -0.6 -2.4 0.2 0.6 0.1
Medication: Ramipril 0.7 0.9 1.6 0.8 -0.5 0.9 1.3 1.1 1.1
Medication: Simvastatin 4.1 6.0 8.5 2.3 -2.3 -1.9 2.7 2.5 2.9
Fluid intelligence score 0.9 1.9 4.3 -1.4 1.4 0.5 -0.3 -2.1 -1.7
Illnesses of siblings 1.9 2.6 6.0 -1.5 1.4 0.3 -2.4 -1.8 -1.5
Neuroticism score 0.3 0.5 1.4 -0.2 0.3 0.2 1.2 -1.2 -0.5
Weight 0.2 0.9 3.5 0.5 -0.5 0.0 1.9 0.8 0.7
Impedance of arm (right) 2.7 12.6 17.6 -4.1 4.2 1.0 -3.3 -3.6 -4.1
Arm fat percentage (right) 0.1 0.5 1.2 -1.0 1.1 0.4 0.5 0.0 -0.8
Trunk fat-free mass 0.4 2.2 2.9 1.6 -1.7 0.5 1.6 1.5 1.6
Hip circumference 0.1 0.5 1.6 0.2 -0.1 0.4 1.3 0.9 0.5
Time employed in main current job 1.3 1.5 2.7 -1.5 1.7 -0.9 -1.3 -0.7 -1.1
Alcohol intake versus 10 years previously 0.2 0.2 1.1 0.2 -0.3 -0.1 1.1 0.3 0.1
Father’s age at death 1.7 2.3 3.4 -1.0 0.9 1.8 -1.3 -1.8 -1.8
Worrier / anxious feelings 0.5 0.9 4.3 0.5 -0.5 0.0 2.1 -0.9 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 -0.6 0.7 0.8 0.9 -0.9 -0.8
Falls in the last year 0.3 0.4 1.0 -0.6 0.8 1.0 0.2 -0.1 -0.5
Hair/balding pattern: Pattern 3 3.2 4.7 7.6 2.6 -2.8 -0.8 1.3 2.3 2.6
Number of live births 3.2 4.5 6.9 -2.6 2.5 1.0 -1.9 -2.3 -2.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 1.3 -0.9 1.1 -0.6 0.5 -0.7 -0.3
Pulse rate 0.4 0.7 1.7 -0.8 0.6 0.2 -0.3 -1.3 -1.2
Happiness 0.2 0.2 0.5 -0.7 0.7 0.4 -0.3 -0.3 -0.3
Noisy workplace 0.4 0.5 1.2 -0.2 0.3 1.1 -1.1 0.4 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.2 -0.6 0.6 0.9 -0.5 -1.1 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 0.8 0.9 -0.8 0.9 0.6 0.4 0.8
Mouth/teeth dental problems: Dentures 3.8 6.5 9.8 -2.6 2.7 1.3 -1.9 -3.1 -3.1
Asthma 3.9 7.8 8.5 2.9 -2.8 -2.9 2.8 2.3 2.9
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.6 0.5 -0.6 0.0 -0.8 0.0 0.1
Medication: Cholesterol lowering 0.4 0.7 1.4 0.6 -0.4 -0.4 1.2 1.2 0.7
Depression (self-reported) 2.5 3.0 4.3 -1.7 1.7 1.7 -0.5 -2.1 -2.1
Medication: Lansoprazole 1.3 1.5 2.2 1.5 -1.4 -0.6 1.4 1.2 0.9
Prospective memory result 0.7 0.8 3.0 0.4 -0.5 -1.7 0.3 1.0 0.7
Lung cancer (father) 1.8 2.1 3.3 1.7 -1.8 -0.4 1.5 1.1 1.6
Illnesses of mother 1.1 1.4 4.1 -1.0 1.0 -0.0 -1.1 -2.0 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.6 -1.4 1.6 0.4 -0.5 -1.0 -0.8
Pulse wave Arterial Stiffness index 1.0 1.2 2.1 -1.4 1.4 -0.3 -0.0 -1.3 -1.3
Impedance of arm (left) 1.9 8.6 11.9 -3.1 3.2 0.4 -3.2 -3.1 -3.5
Arm fat mass (right) 0.2 0.7 2.7 0.2 -0.2 0.3 1.7 1.0 0.4
Trunk predicted mass 0.4 2.1 2.9 1.6 -1.7 0.5 1.6 1.5 1.6
Standing height 0.1 1.2 3.1 -1.0 1.0 0.7 -0.6 -1.8 -1.2
Length of working week for main job 0.6 0.7 2.1 0.1 -0.0 -1.5 1.2 0.4 0.6
Exposure to tobacco smoke at home 1.3 1.4 5.0 -0.6 0.7 2.2 -0.7 -1.4 -0.5
Breastfed as a baby 0.1 0.1 0.3 0.1 -0.1 0.5 0.1 0.5 0.5
Tense / ‘highly strung’ 0.8 1.3 1.9 1.2 -1.4 -1.0 1.0 1.1 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.8 5.3 -1.7 1.6 1.1 -0.9 -2.3 -2.0
Hair/balding pattern: Pattern 4 0.5 1.2 3.3 0.2 -0.0 -1.8 0.8 1.2 1.2
Birth weight of first child 0.5 1.0 2.8 -0.7 0.9 1.7 0.4 -0.7 -1.1
Peak expiratory flow (PEF) 0.3 0.7 1.1 -1.0 1.0 -0.1 0.7 -0.9 -0.8
Pulse wave reflection index 0.5 0.6 1.5 -1.2 1.2 0.2 -0.3 -0.6 -0.7
Ever highly irritable/argumentative for 2 days 0.3 0.3 1.3 0.3 -0.4 0.2 1.2 0.4 0.3
Loud music exposure frequency 0.5 0.5 1.5 0.6 -0.5 -0.7 -0.7 1.2 0.3
Qualifications: O levels/GCSEs or equivalent 2.4 3.8 6.8 -1.8 1.8 1.7 -1.7 -1.9 -2.6
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.8 1.4 -1.2 0.3 0.2 0.8 0.9
Blood clot in the leg (DVT) 0.3 0.4 1.1 -1.0 1.1 0.1 0.2 -0.0 -0.5
Medication: Paracetamol 2.2 3.7 11.7 1.6 -1.7 -1.0 3.4 1.3 1.5
Headache pain in last month 0.4 0.6 1.5 0.2 0.1 -1.2 1.1 -0.9 -0.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 3.2 -1.0 0.8 0.6 -1.7 -1.8 -1.4
Glaucoma (self-reported) 1.5 1.8 3.7 1.4 -1.4 -0.2 -0.6 1.9 1.7
Gout (self-reported) 0.4 0.5 1.7 0.1 -0.2 0.1 0.6 0.9 1.3
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 2.7 1.6 -1.6 -0.9 1.6 1.5 0.9
Medication: Amlodipine 0.2 0.3 1.0 0.1 -0.1 0.2 1.0 0.3 0.9
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.8 0.4 -0.4 -0.6 0.1 0.5 0.9
Birth weight 0.2 0.4 1.2 -0.3 0.4 0.4 -0.8 -0.6 -1.1
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.9 -1.1 1.3 0.9 -1.4 -0.5 -0.5
High blood pressure (siblings) 0.9 1.3 3.9 0.8 -0.6 0.1 2.0 1.4 0.8
Forced vital capacity (FVC), Best measure 0.1 0.3 1.0 -0.7 1.0 0.3 -0.3 -0.5 -0.1
Body fat percentage 0.1 0.3 0.9 -0.7 0.7 0.1 0.9 0.1 -0.3
Leg fat percentage (right) 0.1 0.4 0.9 -0.6 0.5 0.9 0.9 0.4 0.3
Arm fat-free mass (right) 0.7 3.7 5.2 2.0 -2.1 -0.3 2.3 1.8 2.2
Exposure to tobacco smoke outside home 0.7 0.9 3.4 -0.7 0.9 0.9 -1.9 -0.2 -0.4
Comparative body size at age 10 0.3 0.9 3.1 0.5 -0.4 -1.2 1.8 0.1 0.4
Number of full brothers 0.4 0.5 1.5 -0.2 -0.0 0.2 1.2 0.8 1.0
Worry too long after embarrassment 1.3 2.2 3.8 1.7 -1.6 -1.2 1.9 0.7 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.5 2.6 -0.9 0.9 1.2 -1.1 -1.6 -1.5
Wheeze or whistling in the chest in last year 1.8 3.3 6.7 1.7 -1.7 -1.3 2.6 1.6 1.8
Number of children fathered 0.4 0.5 1.9 -0.1 0.0 0.9 1.4 -0.3 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 1.6 1.3 -1.1 0.8 -0.0 1.2 0.9
Age at first live birth 0.1 0.2 0.8 0.4 -0.4 -0.4 -0.9 0.2 -0.2
Pulse wave peak to peak time 1.1 1.3 2.3 1.5 -1.4 0.3 0.2 1.3 1.4
Health satisfaction 0.4 0.5 1.4 -0.6 0.8 -0.5 0.1 -0.7 -1.2
Shortness of breath walking on level ground 1.9 2.3 6.8 0.9 -1.0 -2.6 1.3 1.4 1.2
Qualifications: College or University degree 1.4 4.5 10.0 -1.8 1.6 0.6 -2.0 -2.6 -3.2
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.0 -0.2 -0.2 -0.5 -0.2 -0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 -0.4 0.4 -0.5 -0.2 -0.3 -0.0
Emphysema/chronic bronchitis 0.8 0.9 2.2 0.6 -0.6 -1.5 -0.2 1.4 0.7
Medication for pain relief, constipation, heartburn 0.5 0.9 2.4 -1.0 1.0 0.4 -1.6 -0.7 -0.7
Neck or shoulder pain in last month 1.2 1.7 3.4 1.3 -1.2 0.6 1.8 1.1 1.5
Medication: Blood pressure 1.2 2.2 5.7 0.8 -0.8 -0.7 2.4 1.7 1.7
Angina (self-reported) 0.8 1.1 3.9 0.4 -0.4 -1.2 2.0 0.8 0.5
Migraine (self-reported) 1.4 1.7 4.6 -1.2 1.3 -0.5 -0.7 -2.1 -1.3
Medication: Ibuprofen 0.1 0.1 0.3 0.5 -0.6 0.2 -0.1 0.1 0.1
Medication: Allopurinol 0.1 0.2 0.9 -0.1 -0.0 0.1 0.3 0.5 0.9
Medication: Omeprazole 0.9 1.0 2.2 -1.1 1.0 -0.6 -0.5 -1.1 -1.5
Medication: Seretide 50 evohaler 1.4 1.6 2.6 1.1 -0.9 -1.2 1.6 1.3 1.5
Mean time to correctly identify matches 1.2 2.3 3.5 1.8 -1.9 -0.3 0.4 1.8 1.8
Heart disease (mother) 0.4 0.5 1.6 0.2 -0.3 -0.6 0.9 1.2 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.4 4.0 6.2 2.4 -2.5 0.7 0.4 2.5 2.4
Whole body fat mass 0.1 0.5 2.4 0.1 -0.1 0.1 1.6 0.7 0.4
Leg fat mass (right) 0.2 0.7 2.7 0.1 -0.1 0.4 1.6 0.8 0.6
Arm predicted mass (right) 1.0 5.2 7.0 2.5 -2.5 -0.3 2.5 2.2 2.6
Pulse rate, automated reading 0.1 0.2 0.6 -0.0 -0.1 0.8 -0.3 -0.5 -0.5
Alcohol intake frequency. 0.5 1.2 4.0 -0.6 0.6 -2.0 1.4 -0.3 -0.5
Comparative height size at age 10 0.1 0.5 2.3 0.5 -0.4 -0.3 1.5 0.1 0.5
Number of full sisters 1.2 1.4 4.0 -0.9 0.9 2.0 0.3 -1.3 -1.1
Suffer from ‘nerves’ 2.1 3.3 5.9 -2.1 2.0 0.4 -1.2 -2.4 -1.8
Overall health rating 0.4 0.8 2.5 0.8 -0.8 -0.2 1.6 0.6 0.8
Chest pain or discomfort 0.3 0.4 1.5 0.6 -0.6 -0.4 1.2 0.3 0.2
Had major operations 0.3 0.4 1.7 0.4 -0.4 -0.5 1.3 0.0 -0.2
Age at last live birth 0.1 0.1 0.4 0.3 -0.3 0.3 -0.7 0.1 0.4
Family relationship satisfaction 1.0 1.2 3.2 -1.8 1.6 0.3 -0.9 -0.5 -0.6
Leg pain on walking 0.2 0.3 1.0 0.3 -0.5 1.0 -0.6 0.4 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.4 1.1 0.3 -0.2 0.9 1.0 -0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.5 0.7 -0.6 -0.2 1.6 0.8 0.8
Illness, injury, bereavement, stress in last 2 years 1.4 1.8 3.1 1.8 -1.7 -0.6 0.2 1.5 1.4
Medication: Aspirin 0.9 1.2 2.8 0.6 -0.5 -0.7 1.7 1.4 1.1
Supplements: Vitamin C 2.7 3.2 5.2 2.1 -2.1 -0.4 0.7 2.3 2.1
Knee pain experienced in last month 3.1 4.8 7.8 2.2 -2.2 -0.9 2.3 2.8 2.2
Hypertension (Self-reported) 1.7 4.7 8.3 1.2 -1.3 -2.2 2.9 2.5 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.6 0.1 0.0 0.8 -0.2 0.3 -0.3
Illnesses of father: Heart disease 0.9 1.2 3.6 -0.5 0.4 -1.7 1.9 0.7 0.3
Illnesses of siblings: Diabetes 6.3 7.7 10.9 3.0 -2.8 -1.7 2.6 3.3 3.1
Smoking status: Previous 0.8 1.2 1.9 1.0 -1.1 1.4 0.2 1.3 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 2.2 0.1 0.0 1.5 -0.6 -0.4 0.3
Whole body fat-free mass 0.4 2.1 3.7 1.5 -1.6 -0.1 1.9 1.4 1.4
Leg fat-free mass (right) 0.3 1.3 3.5 1.0 -0.9 -1.3 1.9 0.7 0.6
Arm fat percentage (left) 0.1 0.3 0.5 -0.6 0.7 0.0 0.7 0.2 -0.5
Average weekly red wine intake 1.3 2.0 5.0 1.5 -1.3 0.2 -0.3 2.2 1.7
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.4 -0.4 0.6 0.2 0.3 0.1 0.1
Mood swings 0.4 0.7 1.9 -0.8 0.8 0.5 0.7 -1.4 -0.6
Loneliness, isolation 0.6 0.8 1.7 -1.3 1.3 -0.2 0.3 -0.9 -0.9
Long-standing illness, disability or infirmity 0.5 0.7 1.3 0.8 -1.0 1.1 1.2 0.1 0.4
Ever had bowel cancer screening 1.7 2.0 3.3 1.5 -1.6 1.8 0.6 1.2 1.5
Diabetes diagnosed by doctor 2.0 3.4 7.7 1.5 -1.3 -0.9 2.8 2.0 1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.2 0.2 -0.1 -0.5 0.2 0.1
Friendships satisfaction 0.3 0.3 1.0 -0.4 0.4 1.0 -0.4 0.5 0.6
Qualifications: nursing, teaching 0.4 0.6 1.0 -1.0 0.9 0.3 -0.4 -0.9 -1.0
Commuting to job workplace: Walk 0.9 0.9 1.9 -0.8 1.0 0.4 -0.8 -1.1 -1.4
Eye problems/disorders: Cataract 0.3 0.4 1.8 0.4 -0.1 0.4 1.4 0.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 3.4 0.2 -0.2 -1.9 -0.7 0.5 -0.0
Medication for cholesterol 1.6 2.4 3.9 -1.2 1.2 1.3 -1.6 -1.8 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.2 1.3 -1.0 2.0 1.8 0.4 0.8
Back pain experienced in last month 1.4 2.1 3.7 1.8 -1.7 0.8 1.9 0.6 1.2
Mineral and other dietary supplements 0.3 0.4 0.6 -0.7 0.7 0.8 -0.7 -0.0 -0.3
Breast cancer (self-reported) 1.2 1.4 3.5 -0.9 1.0 -1.0 0.1 -1.9 -1.5
Asthma (self-reported) 3.2 6.4 7.3 2.7 -2.6 -2.5 2.4 2.2 2.7
Osteoporosis (self-reported) 0.6 0.7 1.8 -0.7 0.6 1.0 -0.1 -1.4 -0.9
Osteoarthritis (self-reported) 0.3 0.4 1.8 -0.1 -0.1 0.7 1.3 0.4 0.2
Medication: Aspirin 0.7 0.9 2.9 0.3 -0.2 -0.4 1.7 1.1 0.9
Medication: Gliclazide 0.6 0.7 2.8 0.3 -0.3 -1.1 1.7 -0.0 0.1
Illnesses of father: None of the above (group 1) 1.9 2.3 3.8 -1.5 1.4 0.4 -1.9 -2.0 -1.4
Smoking status: Current 1.1 1.8 2.4 -1.5 1.6 1.5 -0.5 -1.5 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -0.9 1.0 1.3 -0.8 -0.6 -0.8
Whole body water mass 0.4 2.0 3.8 1.5 -1.5 -0.2 1.9 1.3 1.4
Leg predicted mass (right) 0.3 1.4 3.7 1.1 -1.0 -1.3 1.9 0.7 0.6
Arm fat mass (left) 0.1 0.5 2.2 0.1 -0.1 0.2 1.5 0.8 0.3
Number of self-reported non-cancer illnesses 0.7 1.2 1.8 1.4 -1.1 -0.8 1.2 1.1 0.9
Average weekly champagne plus white wine intake 0.2 0.2 0.4 -0.6 0.2 0.6 -0.6 -0.3 -0.6
Miserableness 0.9 1.5 2.7 -0.9 1.0 1.6 0.5 -1.6 -1.4
Guilty feelings 0.2 0.3 1.2 -0.3 0.3 1.1 0.3 -0.7 -0.3
Wears glasses or contact lenses 0.4 0.5 1.2 -0.5 0.4 -0.5 -0.5 -0.9 -1.1
Ever taken oral contraceptive pill 0.1 0.1 0.2 0.0 -0.0 -0.4 0.1 0.4 0.4
Hearing aid user 0.2 0.2 0.8 -0.1 0.2 0.9 0.5 0.2 -0.5
Mother’s age at death 0.4 0.5 1.2 1.1 -1.1 0.3 -0.4 0.5 -0.2
Financial situation satisfaction 0.7 0.9 4.2 0.4 -0.4 -0.6 2.0 -0.3 0.5
Tinnitus: Yes, now most or all of the time 1.3 1.5 2.7 -1.2 1.2 0.5 -1.5 -0.8 -1.6
Commuting to job workplace: Public transport 0.8 1.0 3.9 -0.4 0.3 0.3 -2.0 -0.9 -0.9
Eye problems/disorders: Glaucoma 0.4 0.5 0.8 0.5 -0.4 0.8 -0.9 0.8 0.5
Medication: Blood pressure 1.1 2.1 3.2 0.6 -0.6 -1.7 1.7 1.7 1.8
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.4 0.4 -0.5 -0.7 1.2 0.9 1.1
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.8 -0.9 0.9 -0.1 -0.3 -1.4 -1.1
High cholesterol (Self-reported) 1.0 1.8 4.3 0.7 -0.6 -2.0 2.1 0.9 0.9
Medication: Bendroflumethiazide 0.3 0.4 1.3 -1.0 1.2 -0.1 0.3 -0.1 -0.3
Medication: Paracetamol 1.5 2.4 7.0 1.5 -1.5 -0.3 2.6 1.0 1.3
Medication: Lisinopril 0.4 0.5 1.6 0.0 -0.1 -1.3 0.5 0.8 0.8
Medication: Atorvastatin 1.4 1.8 3.7 -1.8 1.6 -0.7 0.1 -0.8 -1.9
Illnesses of father: High blood pressure 0.4 0.5 0.8 -0.9 0.6 0.9 0.6 -0.8 -0.6
Alcohol drinker status: Never 0.8 1.0 1.7 -1.1 1.1 -0.7 -0.8 -0.9 -1.3
Ever smoked 0.5 0.9 4.7 -0.5 0.5 2.2 -0.2 -0.5 -0.0
Basal metabolic rate 0.3 1.8 4.0 1.3 -1.3 -0.0 2.0 1.3 1.3
Leg fat percentage (left) 0.1 0.3 1.0 -0.3 0.3 0.5 1.0 0.4 0.4
Arm fat-free mass (left) 0.5 2.4 4.8 1.5 -1.6 0.6 2.2 1.3 1.7
Number of operations (self-reported) 0.8 1.2 2.9 -1.0 1.0 0.1 0.1 -1.7 -1.5
Average weekly beer plus cider intake 0.5 0.7 1.9 0.9 -0.9 0.3 0.7 0.4 1.4
Irritability 0.1 0.2 0.5 -0.3 0.4 0.4 0.2 -0.7 -0.5
Risk taking 2.9 4.2 7.5 1.9 -2.0 0.5 2.0 2.4 2.7
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.4 0.9 -0.8 -0.4 1.5 0.7 1.2
Fractured/broken bones in last 5 years 1.7 2.2 3.4 -1.7 1.8 -1.8 -0.4 -1.1 -1.5
Age started oral contraceptive pill 0.3 0.4 2.1 0.0 -0.0 -1.4 -0.5 -0.1 0.1
Diastolic blood pressure, automated reading 0.3 1.0 1.9 -0.0 0.1 -1.4 0.7 1.4 1.4
Ever depressed for a whole week 0.5 0.7 3.8 0.0 -0.1 1.9 -0.3 -0.4 -0.2
Unable to work because of sickness or disability 0.3 0.4 0.7 -0.8 0.8 0.4 0.5 -0.3 -0.5
Commuting to job workplace: Cycle 0.4 0.5 2.2 0.3 -0.4 -1.5 0.3 0.6 0.3
Myopia 0.5 0.8 2.4 0.8 -1.0 -1.6 0.2 0.3 0.6
Vascular/heart problems diagnosed by doctor 1.1 2.9 5.3 -0.7 0.8 1.5 -2.3 -2.3 -1.8
Cholesterol lowering medication 4.2 6.2 10.0 2.1 -2.2 -2.4 3.2 2.4 2.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.2 -0.8 0.7 -1.0 -0.4 -0.8 -1.1
Pain experienced in last month 2.6 4.4 6.2 -2.5 2.4 0.4 -2.2 -2.3 -2.0
Supplements: Calcium 1.0 1.1 2.8 1.4 -1.7 -0.2 0.5 0.7 1.1
Basal cell carcinoma (self-reported) 0.4 0.4 1.3 0.1 -0.1 -1.1 -1.0 0.5 0.2
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.0 0.6 -0.6 0.1 1.4 1.1 0.9
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.8 -0.9 0.9 0.4 0.2 0.1 -0.3
Heart disease (siblings) 0.6 0.8 2.3 0.8 -0.8 0.4 1.5 0.7 0.6
Alcohol drinker status: Previous 2.4 2.8 4.5 -2.1 2.1 -0.4 -0.3 -1.9 -1.9
Pack years of smoking 0.2 0.2 0.5 0.3 -0.3 0.7 0.5 0.1 0.6
Impedance of whole body 1.2 6.2 7.9 -2.8 2.8 1.1 -2.6 -2.7 -2.5
Leg fat mass (left) 0.2 0.6 2.5 0.2 -0.2 0.1 1.6 0.8 0.6
Arm predicted mass (left) 0.6 3.1 5.3 1.8 -1.9 0.6 2.3 1.6 1.9