Hub : Genes

CDK9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0530	0.0220	1.0e-03	0.067	0.021	0.047	0.033	0.059	1.4e-08	1.2e-03	2.1e-06	5.4e-05	1.1e-07
2	GTEx	Skin Sun Exposed Lower leg	0.0660	0.0290	3.9e-03	0.046	NA	0.032	NA	0.039	1.0e-04	NA	1.1e-03	NA	3.6e-04
3	GTEx	Uterus	0.4580	0.1240	3.3e-03	-0.006	NA	-0.015	NA	-0.014	4.4e-01	NA	9.4e-01	NA	7.8e-01
4	YFS	Blood	0.0328	0.0117	2.8e-05	0.009	0.022	0.017	0.021	0.016	5.3e-04	8.0e-08	1.6e-06	1.1e-07	3.2e-06
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0195	0.0115	7.4e-03	0.012	0.017	0.007	NA	0.012	1.4e-02	4.7e-03	5.3e-02	NA	1.4e-02
6	TCGA	Prostate Adenocarcinoma	0.0157	0.0095	9.9e-03	0.014	0.019	0.012	NA	0.015	1.1e-02	3.6e-03	1.9e-02	NA	1.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.2	1.8	4.6	0.9	-1.0	-1.5	2.1	0.9	1.2
Bipolar Disorder or Schizophrenia	1.0	2.5	4.5	1.7	-1.7	-0.5	1.4	1.7	2.1
Depressed Affect (Nagel 2018)	1.2	2.6	5.0	-1.8	1.8	0.2	0.5	-2.2	-2.0
Depression (Nagel 2018)	0.0	0.1	0.3	0.1	-0.0	-0.5	0.2	0.2	0.2
Intelligence (Savage-Jansen 2018)	1.6	4.9	8.1	-2.0	1.9	1.5	-2.0	-2.8	-2.9
Neuroticism (Nagel 2018)	0.4	0.8	2.2	-0.4	0.4	0.1	1.4	-1.5	-0.7
Schizophrenia (2018)	0.8	1.6	3.2	1.4	-1.3	0.6	0.1	1.4	1.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.8	-1.0	-0.0	0.1	0.3	0.7
Worry (Nagel 2018)	0.3	0.6	1.7	-0.2	0.1	-0.9	1.3	-1.0	-0.1
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	0.6	-0.5	0.1	0.6	0.9	0.9
Alzheimer’s Disease (in father)	0.5	0.5	1.7	0.6	-0.6	-1.3	-0.7	0.5	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.7	-0.6	-0.3	-0.1	0.8	0.8
Crohns Disease (2017)	1.5	3.3	8.2	-1.6	1.7	-0.9	-0.7	-2.3	-2.9
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	0.8	-0.8	-1.0	0.8	0.4	0.2
Ulcerative Colitis (UC)	2.1	3.9	5.7	2.2	-2.3	-0.8	1.6	2.2	2.4
Major Depression (MDD)	0.5	0.6	3.1	-0.3	0.3	1.8	0.6	0.0	0.0
Reaction Time	0.9	1.7	2.9	1.5	-1.5	0.1	0.2	1.7	1.7
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.6	-1.4	1.3	-0.6	-0.6	-1.9	-1.8
Breast Cancer	0.5	1.2	2.3	-1.4	1.5	1.0	-0.5	-0.8	-0.9
Ovarian Cancer	0.4	0.5	0.8	-0.6	0.4	0.6	-0.9	-0.8	-0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.3	1.9	2.6	-0.8	0.7	1.6	-1.6	-1.6	-1.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.7	6.0	0.6	-0.5	-1.7	2.5	0.5	0.6
Coronary Artery Disease (CAD)	0.5	0.5	1.0	-0.4	0.7	-0.9	0.4	-1.0	-0.8
Crohns Disease (2012)	1.1	1.9	3.8	-0.7	0.7	-1.9	0.5	-1.5	-2.0
Mean Putamen Volume	1.1	1.3	2.7	1.2	-1.2	0.1	1.6	1.1	0.8
Fasting Glucose	0.6	0.8	3.3	-0.0	-0.0	-1.8	0.8	0.6	0.4
HbA1C	3.5	3.9	5.3	2.2	-2.3	-1.2	1.9	2.1	2.0
HDL Cholesterol	1.0	1.7	3.0	1.4	-1.3	1.2	0.5	1.3	1.7
LDL Cholesterol	0.7	1.2	5.4	-0.2	-0.3	-2.3	0.1	1.1	0.4
Lupus	2.3	3.5	6.1	-2.3	2.2	0.4	-1.7	-1.3	-2.5
Neuroticism (2016)	2.2	3.2	4.9	2.1	-2.2	-0.4	2.2	1.3	1.8
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.2	0.2	-0.0	0.4	-0.6	-0.6
Rheumatoid Arthritis	0.4	0.5	0.9	0.8	-0.9	0.9	1.0	-0.2	0.3
Schizophrenia (2014)	0.5	1.2	3.2	0.9	-1.0	0.9	0.1	1.1	1.8
Triglycerides	0.6	1.0	2.6	-1.0	1.2	-1.6	0.2	-0.4	-1.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.1	0.0	0.1	0.6	0.8	0.6
Ulcerative Colitis	1.9	2.7	3.2	1.6	-1.7	-1.7	1.5	1.6	1.8
Blood Eosinophil Count	1.1	8.5	13.9	-2.8	2.5	3.2	-1.2	-3.3	-3.7
Blood Platelet Count	0.1	0.9	1.4	-1.1	1.2	-1.0	-1.1	0.8	0.2
Blood Red Count	0.2	2.2	6.6	0.2	-0.4	2.2	2.6	0.5	1.0
Blood White Count	0.5	3.3	7.9	1.6	-1.6	1.5	0.2	2.8	2.2
Heel T-Score	5.4	43.2	53.0	6.9	-6.7	-4.8	6.8	6.7	7.3
BMI	1.1	6.1	15.2	2.1	-2.1	-1.2	3.9	2.6	2.1
Height	0.4	7.9	19.5	-1.5	1.5	4.4	-3.0	-2.8	-2.6
Waist Hip Ratio (WHR)	0.2	1.0	2.5	-1.2	1.1	0.2	0.0	-1.6	-0.8
Systolic Blood Pressure	0.6	2.9	7.0	0.4	-0.3	-0.6	2.2	2.6	2.2
Smoking Status	0.4	0.9	3.8	0.3	-0.5	2.0	0.7	0.4	0.7
Allergy or Eczema	0.6	1.5	2.7	1.7	-1.6	-0.4	0.4	1.7	0.9
Cardiovascular Disease	2.5	8.4	15.8	1.9	-1.8	-2.5	4.0	3.2	3.3
Hypothyroidism (self reported)	0.5	1.1	2.0	1.0	-1.1	0.6	1.2	1.4	0.9
Respiratory disease	2.2	4.9	7.1	2.1	-2.0	-2.2	2.7	2.1	2.2
Type 2 Diabetes (T2D) (2018)	2.2	4.0	6.4	1.6	-1.5	-1.3	2.5	2.5	2.3
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.9	0.8	0.4	0.5	-0.9	-0.5
Lung FVC	0.1	0.5	1.1	-0.9	1.0	0.6	0.6	-0.8	-0.3
Neuroticism	0.6	1.4	3.7	-0.7	0.8	0.2	1.9	-1.6	-1.1
Chronotype (morning person)	1.5	3.4	14.1	0.9	-1.0	-3.8	1.7	1.0	0.7
Hair Pigment	0.1	2.7	4.5	2.1	-2.0	-0.6	0.7	1.5	2.1
Tanning	0.0	0.5	2.2	0.2	-0.2	-1.5	0.3	0.5	0.1
Hand grip strength (left)	1.2	3.2	5.0	2.2	-2.2	0.7	0.4	2.0	2.2
Number of treatments/medications taken	0.4	0.7	3.6	0.3	-0.4	-0.2	1.9	0.3	0.3
Average weekly spirits intake	1.6	2.0	3.5	-1.2	1.5	1.1	-1.2	-1.4	-1.9
Sensitivity / hurt feelings	1.2	2.1	5.0	-1.0	1.1	2.2	-0.4	-1.8	-1.5
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.1	-0.1	-0.3	0.2	0.4	0.2
Hearing difficulty/problems: Yes	1.3	2.0	5.4	-0.8	0.9	2.3	-0.6	-1.5	-1.6
Relative age of first facial hair	0.5	1.1	2.2	-0.9	0.6	0.8	-1.0	-1.2	-1.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	1.0	-0.1	-0.2	0.0	1.0	0.0	0.3
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.5	-1.6	1.5	0.8	-2.1	-1.4	-1.7
Ever had hysterectomy (womb removed)	0.9	1.0	3.0	0.9	-0.9	-0.9	1.7	0.3	0.9
Systolic blood pressure, automated reading	1.4	4.0	9.5	1.4	-1.4	-0.9	1.4	3.1	2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.6	0.4	-0.4	-1.1	1.6	0.4	0.8
Angina	0.8	1.0	4.0	0.4	-0.3	-1.1	2.0	0.7	0.4
Medication for hormone replacement therapy	1.7	1.8	2.9	1.7	-1.6	0.3	0.4	1.7	1.6
Vitamin and mineral supplements	0.4	0.6	1.3	-1.1	1.1	-0.3	-0.2	-0.5	-0.9
Supplements: Zinc	0.1	0.2	0.4	0.6	-0.6	-0.2	0.0	0.0	0.3
Medication: Co-codamol	0.2	0.2	0.6	0.0	0.1	-0.0	0.3	-0.8	-0.6
Medication: Metformin	2.6	3.7	6.1	1.9	-2.0	-0.8	2.5	1.7	2.2
Diabetes (father)	2.7	3.4	6.0	2.5	-2.3	-0.1	1.7	1.9	1.7
Diabetes (mother)	3.0	3.9	6.7	1.7	-1.9	-0.6	2.6	2.3	2.1
Severe depression (siblings)	0.2	0.2	0.8	-0.2	0.2	-0.5	-0.4	-0.3	-0.9
Pack years adult smoking proportion	0.2	0.3	0.7	0.3	-0.3	0.8	0.4	0.2	0.7
Impedance of leg (right)	0.6	2.9	5.2	-1.8	1.7	2.3	-1.8	-1.5	-0.8
Leg fat-free mass (left)	0.2	0.9	3.1	0.7	-0.7	-0.8	1.8	0.7	0.5
Trunk fat percentage	0.1	0.4	1.1	-0.6	0.7	0.1	1.1	0.0	-0.4
Hand grip strength (right)	0.5	1.4	2.9	1.6	-1.7	0.4	0.4	1.1	1.2
Townsend deprivation index at recruitment	2.7	3.8	5.3	-2.1	2.0	2.3	-1.7	-1.8	-1.8
Current tobacco smoking	1.2	2.0	3.3	-1.6	1.6	1.8	-0.7	-1.4	-1.0
Average weekly fortified wine intake	0.4	0.5	2.3	0.5	-0.5	0.3	1.5	-0.3	0.1
Maternal smoking around birth	0.7	1.0	3.0	0.3	-0.1	1.2	-1.7	0.9	0.9
Fed-up feelings	0.3	0.5	0.9	-0.4	0.5	-1.0	0.7	-0.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.5	1.1	-1.1	-0.1	1.1	0.9	1.2
Relative age voice broke	0.3	0.5	0.8	-0.8	0.7	-0.6	-0.6	-0.6	-0.9
Taking other prescription medications	0.1	0.1	0.3	0.4	-0.4	-0.2	0.4	-0.0	-0.6
Age when periods started (menarche)	1.7	4.0	6.4	-1.8	1.8	2.5	-1.9	-2.0	-1.8
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	6.7	0.8	-0.8	-2.6	0.8	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	6.3	14.2	21.0	3.2	-3.3	-2.5	4.1	4.5	4.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.1	-1.0	1.1	-0.9	-0.0	-0.5	-1.1
Qualifications: CSEs or equivalent	0.9	1.2	2.7	0.9	-0.8	-1.0	1.6	0.9	1.2
Serious illness, injury or assault to yourself	3.4	4.2	6.2	-2.5	2.4	0.2	-1.3	-2.3	-2.4
High blood pressure	1.6	4.4	6.8	1.2	-1.3	-2.1	2.6	2.6	2.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.9	1.7	-1.7	-0.5	0.4	1.2	1.2
Multivitamins +/- minerals	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.4	-0.2	0.0
Stomach or abdominal pain in last month	0.3	0.4	0.8	0.9	-0.6	0.0	0.9	0.4	0.0
Supplements: Glucosamine	2.9	3.8	6.3	2.2	-2.2	0.1	1.3	2.5	2.3
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	6.0	2.5	-2.3	0.1	2.3	1.6	2.0
Medication: Atenolol	0.9	1.1	2.2	0.6	-0.5	-1.5	1.2	1.1	1.0
Medication: Levothyroxine sodium	0.8	1.4	1.9	1.4	-1.3	-1.4	1.4	0.8	0.4
Sitting height	0.0	0.2	0.6	0.2	-0.2	0.8	0.5	-0.2	0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.6	-0.5	0.6	0.2	0.9	0.7
High blood pressure (mother)	0.3	0.4	1.1	0.0	-0.2	1.1	0.3	0.9	0.5
Body mass index (BMI)	0.5	1.9	4.9	1.0	-1.0	-0.2	2.2	1.7	1.3
Impedance of leg (left)	0.3	1.7	2.9	-1.2	1.2	1.7	-1.6	-1.2	-0.5
Leg predicted mass (left)	0.2	0.8	3.1	0.7	-0.6	-0.8	1.8	0.6	0.4
Trunk fat mass	0.1	0.4	1.8	-0.3	0.4	0.1	1.3	0.3	-0.1
Waist circumference	0.3	1.1	4.2	0.6	-0.7	-0.0	2.0	0.9	0.9
Number of incorrect matches in round	1.5	2.5	3.7	1.9	-1.7	1.4	1.5	1.2	1.6
Past tobacco smoking	0.3	0.5	2.6	-0.1	0.1	-1.6	0.2	-0.4	-0.3
Alcohol usually taken with meals	0.7	1.2	1.8	-1.2	1.2	0.1	-1.3	-0.9	-1.2
Nervous feelings	0.4	0.7	2.0	-0.0	-0.1	-1.4	1.3	-0.8	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.0	-0.7	0.8	1.0	-0.1	-2.0	-1.5
Hearing difficulty/problems with background noise	2.3	3.7	5.9	2.2	-2.1	2.4	1.5	1.6	1.5
Hair/balding pattern: Pattern 2	1.2	1.5	3.9	-0.8	0.8	1.4	-0.6	-2.0	-1.4
Had menopause	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.5	-0.0	-0.0
Had other major operations	4.6	5.6	9.9	-2.5	2.3	2.0	-0.8	-3.1	-2.8
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.6	0.9	-0.7	0.2	-0.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	6.8	15.7	23.4	3.6	-3.7	-2.8	3.8	4.8	4.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	-1.1	1.0	0.4	0.2	-0.9	-1.0
Qualifications: None of the above	2.6	5.7	8.7	2.4	-2.5	-0.7	2.7	2.4	2.9
Financial difficulties in last 2 years	0.5	0.6	2.6	-0.6	0.5	0.8	1.6	-0.3	0.2
Mouth/teeth dental problems	1.0	1.5	2.4	1.1	-1.2	-0.2	1.5	1.3	1.5
Heart attack	0.5	0.6	1.7	0.6	-0.6	0.1	1.3	1.0	0.7
Allergy	2.9	6.6	8.3	-2.9	2.8	1.6	-2.2	-2.8	-2.9
Pain all over the body in last month	1.7	1.8	3.1	-1.8	1.6	-1.1	-0.1	-1.3	-1.4
Diabetes (self-reported)	1.9	3.0	4.0	1.3	-1.2	-1.9	2.0	1.9	1.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	5.9	0.7	-0.6	-2.4	0.2	0.6	0.1
Medication: Ramipril	0.7	0.9	1.6	0.8	-0.5	0.9	1.3	1.1	1.1
Medication: Simvastatin	4.1	6.0	8.5	2.3	-2.3	-1.9	2.7	2.5	2.9
Fluid intelligence score	0.9	1.9	4.3	-1.4	1.4	0.5	-0.3	-2.1	-1.7
Illnesses of siblings	1.9	2.6	6.0	-1.5	1.4	0.3	-2.4	-1.8	-1.5
Neuroticism score	0.3	0.5	1.4	-0.2	0.3	0.2	1.2	-1.2	-0.5
Weight	0.2	0.9	3.5	0.5	-0.5	0.0	1.9	0.8	0.7
Impedance of arm (right)	2.7	12.6	17.6	-4.1	4.2	1.0	-3.3	-3.6	-4.1
Arm fat percentage (right)	0.1	0.5	1.2	-1.0	1.1	0.4	0.5	0.0	-0.8
Trunk fat-free mass	0.4	2.2	2.9	1.6	-1.7	0.5	1.6	1.5	1.6
Hip circumference	0.1	0.5	1.6	0.2	-0.1	0.4	1.3	0.9	0.5
Time employed in main current job	1.3	1.5	2.7	-1.5	1.7	-0.9	-1.3	-0.7	-1.1
Alcohol intake versus 10 years previously	0.2	0.2	1.1	0.2	-0.3	-0.1	1.1	0.3	0.1
Father’s age at death	1.7	2.3	3.4	-1.0	0.9	1.8	-1.3	-1.8	-1.8
Worrier / anxious feelings	0.5	0.9	4.3	0.5	-0.5	0.0	2.1	-0.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.8	-0.6	0.7	0.8	0.9	-0.9	-0.8
Falls in the last year	0.3	0.4	1.0	-0.6	0.8	1.0	0.2	-0.1	-0.5
Hair/balding pattern: Pattern 3	3.2	4.7	7.6	2.6	-2.8	-0.8	1.3	2.3	2.6
Number of live births	3.2	4.5	6.9	-2.6	2.5	1.0	-1.9	-2.3	-2.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.3	-0.9	1.1	-0.6	0.5	-0.7	-0.3
Pulse rate	0.4	0.7	1.7	-0.8	0.6	0.2	-0.3	-1.3	-1.2
Happiness	0.2	0.2	0.5	-0.7	0.7	0.4	-0.3	-0.3	-0.3
Noisy workplace	0.4	0.5	1.2	-0.2	0.3	1.1	-1.1	0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.2	-0.6	0.6	0.9	-0.5	-1.1	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	0.8	0.9	-0.8	0.9	0.6	0.4	0.8
Mouth/teeth dental problems: Dentures	3.8	6.5	9.8	-2.6	2.7	1.3	-1.9	-3.1	-3.1
Asthma	3.9	7.8	8.5	2.9	-2.8	-2.9	2.8	2.3	2.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.5	-0.6	0.0	-0.8	0.0	0.1
Medication: Cholesterol lowering	0.4	0.7	1.4	0.6	-0.4	-0.4	1.2	1.2	0.7
Depression (self-reported)	2.5	3.0	4.3	-1.7	1.7	1.7	-0.5	-2.1	-2.1
Medication: Lansoprazole	1.3	1.5	2.2	1.5	-1.4	-0.6	1.4	1.2	0.9
Prospective memory result	0.7	0.8	3.0	0.4	-0.5	-1.7	0.3	1.0	0.7
Lung cancer (father)	1.8	2.1	3.3	1.7	-1.8	-0.4	1.5	1.1	1.6
Illnesses of mother	1.1	1.4	4.1	-1.0	1.0	-0.0	-1.1	-2.0	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.6	-1.4	1.6	0.4	-0.5	-1.0	-0.8
Pulse wave Arterial Stiffness index	1.0	1.2	2.1	-1.4	1.4	-0.3	-0.0	-1.3	-1.3
Impedance of arm (left)	1.9	8.6	11.9	-3.1	3.2	0.4	-3.2	-3.1	-3.5
Arm fat mass (right)	0.2	0.7	2.7	0.2	-0.2	0.3	1.7	1.0	0.4
Trunk predicted mass	0.4	2.1	2.9	1.6	-1.7	0.5	1.6	1.5	1.6
Standing height	0.1	1.2	3.1	-1.0	1.0	0.7	-0.6	-1.8	-1.2
Length of working week for main job	0.6	0.7	2.1	0.1	-0.0	-1.5	1.2	0.4	0.6
Exposure to tobacco smoke at home	1.3	1.4	5.0	-0.6	0.7	2.2	-0.7	-1.4	-0.5
Breastfed as a baby	0.1	0.1	0.3	0.1	-0.1	0.5	0.1	0.5	0.5
Tense / ‘highly strung’	0.8	1.3	1.9	1.2	-1.4	-1.0	1.0	1.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.8	5.3	-1.7	1.6	1.1	-0.9	-2.3	-2.0
Hair/balding pattern: Pattern 4	0.5	1.2	3.3	0.2	-0.0	-1.8	0.8	1.2	1.2
Birth weight of first child	0.5	1.0	2.8	-0.7	0.9	1.7	0.4	-0.7	-1.1
Peak expiratory flow (PEF)	0.3	0.7	1.1	-1.0	1.0	-0.1	0.7	-0.9	-0.8
Pulse wave reflection index	0.5	0.6	1.5	-1.2	1.2	0.2	-0.3	-0.6	-0.7
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	0.3	-0.4	0.2	1.2	0.4	0.3
Loud music exposure frequency	0.5	0.5	1.5	0.6	-0.5	-0.7	-0.7	1.2	0.3
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	6.8	-1.8	1.8	1.7	-1.7	-1.9	-2.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	1.4	-1.2	0.3	0.2	0.8	0.9
Blood clot in the leg (DVT)	0.3	0.4	1.1	-1.0	1.1	0.1	0.2	-0.0	-0.5
Medication: Paracetamol	2.2	3.7	11.7	1.6	-1.7	-1.0	3.4	1.3	1.5
Headache pain in last month	0.4	0.6	1.5	0.2	0.1	-1.2	1.1	-0.9	-0.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.2	-1.0	0.8	0.6	-1.7	-1.8	-1.4
Glaucoma (self-reported)	1.5	1.8	3.7	1.4	-1.4	-0.2	-0.6	1.9	1.7
Gout (self-reported)	0.4	0.5	1.7	0.1	-0.2	0.1	0.6	0.9	1.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	2.7	1.6	-1.6	-0.9	1.6	1.5	0.9
Medication: Amlodipine	0.2	0.3	1.0	0.1	-0.1	0.2	1.0	0.3	0.9
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.4	-0.4	-0.6	0.1	0.5	0.9
Birth weight	0.2	0.4	1.2	-0.3	0.4	0.4	-0.8	-0.6	-1.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.9	-1.1	1.3	0.9	-1.4	-0.5	-0.5
High blood pressure (siblings)	0.9	1.3	3.9	0.8	-0.6	0.1	2.0	1.4	0.8
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	-0.7	1.0	0.3	-0.3	-0.5	-0.1
Body fat percentage	0.1	0.3	0.9	-0.7	0.7	0.1	0.9	0.1	-0.3
Leg fat percentage (right)	0.1	0.4	0.9	-0.6	0.5	0.9	0.9	0.4	0.3
Arm fat-free mass (right)	0.7	3.7	5.2	2.0	-2.1	-0.3	2.3	1.8	2.2
Exposure to tobacco smoke outside home	0.7	0.9	3.4	-0.7	0.9	0.9	-1.9	-0.2	-0.4
Comparative body size at age 10	0.3	0.9	3.1	0.5	-0.4	-1.2	1.8	0.1	0.4
Number of full brothers	0.4	0.5	1.5	-0.2	-0.0	0.2	1.2	0.8	1.0
Worry too long after embarrassment	1.3	2.2	3.8	1.7	-1.6	-1.2	1.9	0.7	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.6	-0.9	0.9	1.2	-1.1	-1.6	-1.5
Wheeze or whistling in the chest in last year	1.8	3.3	6.7	1.7	-1.7	-1.3	2.6	1.6	1.8
Number of children fathered	0.4	0.5	1.9	-0.1	0.0	0.9	1.4	-0.3	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.6	1.3	-1.1	0.8	-0.0	1.2	0.9
Age at first live birth	0.1	0.2	0.8	0.4	-0.4	-0.4	-0.9	0.2	-0.2
Pulse wave peak to peak time	1.1	1.3	2.3	1.5	-1.4	0.3	0.2	1.3	1.4
Health satisfaction	0.4	0.5	1.4	-0.6	0.8	-0.5	0.1	-0.7	-1.2
Shortness of breath walking on level ground	1.9	2.3	6.8	0.9	-1.0	-2.6	1.3	1.4	1.2
Qualifications: College or University degree	1.4	4.5	10.0	-1.8	1.6	0.6	-2.0	-2.6	-3.2
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.0	-0.2	-0.2	-0.5	-0.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	0.4	-0.5	-0.2	-0.3	-0.0
Emphysema/chronic bronchitis	0.8	0.9	2.2	0.6	-0.6	-1.5	-0.2	1.4	0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	2.4	-1.0	1.0	0.4	-1.6	-0.7	-0.7
Neck or shoulder pain in last month	1.2	1.7	3.4	1.3	-1.2	0.6	1.8	1.1	1.5
Medication: Blood pressure	1.2	2.2	5.7	0.8	-0.8	-0.7	2.4	1.7	1.7
Angina (self-reported)	0.8	1.1	3.9	0.4	-0.4	-1.2	2.0	0.8	0.5
Migraine (self-reported)	1.4	1.7	4.6	-1.2	1.3	-0.5	-0.7	-2.1	-1.3
Medication: Ibuprofen	0.1	0.1	0.3	0.5	-0.6	0.2	-0.1	0.1	0.1
Medication: Allopurinol	0.1	0.2	0.9	-0.1	-0.0	0.1	0.3	0.5	0.9
Medication: Omeprazole	0.9	1.0	2.2	-1.1	1.0	-0.6	-0.5	-1.1	-1.5
Medication: Seretide 50 evohaler	1.4	1.6	2.6	1.1	-0.9	-1.2	1.6	1.3	1.5
Mean time to correctly identify matches	1.2	2.3	3.5	1.8	-1.9	-0.3	0.4	1.8	1.8
Heart disease (mother)	0.4	0.5	1.6	0.2	-0.3	-0.6	0.9	1.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.4	4.0	6.2	2.4	-2.5	0.7	0.4	2.5	2.4
Whole body fat mass	0.1	0.5	2.4	0.1	-0.1	0.1	1.6	0.7	0.4
Leg fat mass (right)	0.2	0.7	2.7	0.1	-0.1	0.4	1.6	0.8	0.6
Arm predicted mass (right)	1.0	5.2	7.0	2.5	-2.5	-0.3	2.5	2.2	2.6
Pulse rate, automated reading	0.1	0.2	0.6	-0.0	-0.1	0.8	-0.3	-0.5	-0.5
Alcohol intake frequency.	0.5	1.2	4.0	-0.6	0.6	-2.0	1.4	-0.3	-0.5
Comparative height size at age 10	0.1	0.5	2.3	0.5	-0.4	-0.3	1.5	0.1	0.5
Number of full sisters	1.2	1.4	4.0	-0.9	0.9	2.0	0.3	-1.3	-1.1
Suffer from ‘nerves’	2.1	3.3	5.9	-2.1	2.0	0.4	-1.2	-2.4	-1.8
Overall health rating	0.4	0.8	2.5	0.8	-0.8	-0.2	1.6	0.6	0.8
Chest pain or discomfort	0.3	0.4	1.5	0.6	-0.6	-0.4	1.2	0.3	0.2
Had major operations	0.3	0.4	1.7	0.4	-0.4	-0.5	1.3	0.0	-0.2
Age at last live birth	0.1	0.1	0.4	0.3	-0.3	0.3	-0.7	0.1	0.4
Family relationship satisfaction	1.0	1.2	3.2	-1.8	1.6	0.3	-0.9	-0.5	-0.6
Leg pain on walking	0.2	0.3	1.0	0.3	-0.5	1.0	-0.6	0.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	0.3	-0.2	0.9	1.0	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.5	0.7	-0.6	-0.2	1.6	0.8	0.8
Illness, injury, bereavement, stress in last 2 years	1.4	1.8	3.1	1.8	-1.7	-0.6	0.2	1.5	1.4
Medication: Aspirin	0.9	1.2	2.8	0.6	-0.5	-0.7	1.7	1.4	1.1
Supplements: Vitamin C	2.7	3.2	5.2	2.1	-2.1	-0.4	0.7	2.3	2.1
Knee pain experienced in last month	3.1	4.8	7.8	2.2	-2.2	-0.9	2.3	2.8	2.2
Hypertension (Self-reported)	1.7	4.7	8.3	1.2	-1.3	-2.2	2.9	2.5	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	0.1	0.0	0.8	-0.2	0.3	-0.3
Illnesses of father: Heart disease	0.9	1.2	3.6	-0.5	0.4	-1.7	1.9	0.7	0.3
Illnesses of siblings: Diabetes	6.3	7.7	10.9	3.0	-2.8	-1.7	2.6	3.3	3.1
Smoking status: Previous	0.8	1.2	1.9	1.0	-1.1	1.4	0.2	1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.2	0.1	0.0	1.5	-0.6	-0.4	0.3
Whole body fat-free mass	0.4	2.1	3.7	1.5	-1.6	-0.1	1.9	1.4	1.4
Leg fat-free mass (right)	0.3	1.3	3.5	1.0	-0.9	-1.3	1.9	0.7	0.6
Arm fat percentage (left)	0.1	0.3	0.5	-0.6	0.7	0.0	0.7	0.2	-0.5
Average weekly red wine intake	1.3	2.0	5.0	1.5	-1.3	0.2	-0.3	2.2	1.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.4	0.6	0.2	0.3	0.1	0.1
Mood swings	0.4	0.7	1.9	-0.8	0.8	0.5	0.7	-1.4	-0.6
Loneliness, isolation	0.6	0.8	1.7	-1.3	1.3	-0.2	0.3	-0.9	-0.9
Long-standing illness, disability or infirmity	0.5	0.7	1.3	0.8	-1.0	1.1	1.2	0.1	0.4
Ever had bowel cancer screening	1.7	2.0	3.3	1.5	-1.6	1.8	0.6	1.2	1.5
Diabetes diagnosed by doctor	2.0	3.4	7.7	1.5	-1.3	-0.9	2.8	2.0	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.2	0.2	-0.1	-0.5	0.2	0.1
Friendships satisfaction	0.3	0.3	1.0	-0.4	0.4	1.0	-0.4	0.5	0.6
Qualifications: nursing, teaching	0.4	0.6	1.0	-1.0	0.9	0.3	-0.4	-0.9	-1.0
Commuting to job workplace: Walk	0.9	0.9	1.9	-0.8	1.0	0.4	-0.8	-1.1	-1.4
Eye problems/disorders: Cataract	0.3	0.4	1.8	0.4	-0.1	0.4	1.4	0.2	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.4	0.2	-0.2	-1.9	-0.7	0.5	-0.0
Medication for cholesterol	1.6	2.4	3.9	-1.2	1.2	1.3	-1.6	-1.8	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.2	1.3	-1.0	2.0	1.8	0.4	0.8
Back pain experienced in last month	1.4	2.1	3.7	1.8	-1.7	0.8	1.9	0.6	1.2
Mineral and other dietary supplements	0.3	0.4	0.6	-0.7	0.7	0.8	-0.7	-0.0	-0.3
Breast cancer (self-reported)	1.2	1.4	3.5	-0.9	1.0	-1.0	0.1	-1.9	-1.5
Asthma (self-reported)	3.2	6.4	7.3	2.7	-2.6	-2.5	2.4	2.2	2.7
Osteoporosis (self-reported)	0.6	0.7	1.8	-0.7	0.6	1.0	-0.1	-1.4	-0.9
Osteoarthritis (self-reported)	0.3	0.4	1.8	-0.1	-0.1	0.7	1.3	0.4	0.2
Medication: Aspirin	0.7	0.9	2.9	0.3	-0.2	-0.4	1.7	1.1	0.9
Medication: Gliclazide	0.6	0.7	2.8	0.3	-0.3	-1.1	1.7	-0.0	0.1
Illnesses of father: None of the above (group 1)	1.9	2.3	3.8	-1.5	1.4	0.4	-1.9	-2.0	-1.4
Smoking status: Current	1.1	1.8	2.4	-1.5	1.6	1.5	-0.5	-1.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	-0.9	1.0	1.3	-0.8	-0.6	-0.8
Whole body water mass	0.4	2.0	3.8	1.5	-1.5	-0.2	1.9	1.3	1.4
Leg predicted mass (right)	0.3	1.4	3.7	1.1	-1.0	-1.3	1.9	0.7	0.6
Arm fat mass (left)	0.1	0.5	2.2	0.1	-0.1	0.2	1.5	0.8	0.3
Number of self-reported non-cancer illnesses	0.7	1.2	1.8	1.4	-1.1	-0.8	1.2	1.1	0.9
Average weekly champagne plus white wine intake	0.2	0.2	0.4	-0.6	0.2	0.6	-0.6	-0.3	-0.6
Miserableness	0.9	1.5	2.7	-0.9	1.0	1.6	0.5	-1.6	-1.4
Guilty feelings	0.2	0.3	1.2	-0.3	0.3	1.1	0.3	-0.7	-0.3
Wears glasses or contact lenses	0.4	0.5	1.2	-0.5	0.4	-0.5	-0.5	-0.9	-1.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.0	-0.0	-0.4	0.1	0.4	0.4
Hearing aid user	0.2	0.2	0.8	-0.1	0.2	0.9	0.5	0.2	-0.5
Mother’s age at death	0.4	0.5	1.2	1.1	-1.1	0.3	-0.4	0.5	-0.2
Financial situation satisfaction	0.7	0.9	4.2	0.4	-0.4	-0.6	2.0	-0.3	0.5
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.7	-1.2	1.2	0.5	-1.5	-0.8	-1.6
Commuting to job workplace: Public transport	0.8	1.0	3.9	-0.4	0.3	0.3	-2.0	-0.9	-0.9
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	0.5	-0.4	0.8	-0.9	0.8	0.5
Medication: Blood pressure	1.1	2.1	3.2	0.6	-0.6	-1.7	1.7	1.7	1.8
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.4	0.4	-0.5	-0.7	1.2	0.9	1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.8	-0.9	0.9	-0.1	-0.3	-1.4	-1.1
High cholesterol (Self-reported)	1.0	1.8	4.3	0.7	-0.6	-2.0	2.1	0.9	0.9
Medication: Bendroflumethiazide	0.3	0.4	1.3	-1.0	1.2	-0.1	0.3	-0.1	-0.3
Medication: Paracetamol	1.5	2.4	7.0	1.5	-1.5	-0.3	2.6	1.0	1.3
Medication: Lisinopril	0.4	0.5	1.6	0.0	-0.1	-1.3	0.5	0.8	0.8
Medication: Atorvastatin	1.4	1.8	3.7	-1.8	1.6	-0.7	0.1	-0.8	-1.9
Illnesses of father: High blood pressure	0.4	0.5	0.8	-0.9	0.6	0.9	0.6	-0.8	-0.6
Alcohol drinker status: Never	0.8	1.0	1.7	-1.1	1.1	-0.7	-0.8	-0.9	-1.3
Ever smoked	0.5	0.9	4.7	-0.5	0.5	2.2	-0.2	-0.5	-0.0
Basal metabolic rate	0.3	1.8	4.0	1.3	-1.3	-0.0	2.0	1.3	1.3
Leg fat percentage (left)	0.1	0.3	1.0	-0.3	0.3	0.5	1.0	0.4	0.4
Arm fat-free mass (left)	0.5	2.4	4.8	1.5	-1.6	0.6	2.2	1.3	1.7
Number of operations (self-reported)	0.8	1.2	2.9	-1.0	1.0	0.1	0.1	-1.7	-1.5
Average weekly beer plus cider intake	0.5	0.7	1.9	0.9	-0.9	0.3	0.7	0.4	1.4
Irritability	0.1	0.2	0.5	-0.3	0.4	0.4	0.2	-0.7	-0.5
Risk taking	2.9	4.2	7.5	1.9	-2.0	0.5	2.0	2.4	2.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.4	0.9	-0.8	-0.4	1.5	0.7	1.2
Fractured/broken bones in last 5 years	1.7	2.2	3.4	-1.7	1.8	-1.8	-0.4	-1.1	-1.5
Age started oral contraceptive pill	0.3	0.4	2.1	0.0	-0.0	-1.4	-0.5	-0.1	0.1
Diastolic blood pressure, automated reading	0.3	1.0	1.9	-0.0	0.1	-1.4	0.7	1.4	1.4
Ever depressed for a whole week	0.5	0.7	3.8	0.0	-0.1	1.9	-0.3	-0.4	-0.2
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	0.8	0.4	0.5	-0.3	-0.5
Commuting to job workplace: Cycle	0.4	0.5	2.2	0.3	-0.4	-1.5	0.3	0.6	0.3
Myopia	0.5	0.8	2.4	0.8	-1.0	-1.6	0.2	0.3	0.6
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.3	-0.7	0.8	1.5	-2.3	-2.3	-1.8
Cholesterol lowering medication	4.2	6.2	10.0	2.1	-2.2	-2.4	3.2	2.4	2.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.2	-0.8	0.7	-1.0	-0.4	-0.8	-1.1
Pain experienced in last month	2.6	4.4	6.2	-2.5	2.4	0.4	-2.2	-2.3	-2.0
Supplements: Calcium	1.0	1.1	2.8	1.4	-1.7	-0.2	0.5	0.7	1.1
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	0.1	-0.1	-1.1	-1.0	0.5	0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	0.6	-0.6	0.1	1.4	1.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.8	-0.9	0.9	0.4	0.2	0.1	-0.3
Heart disease (siblings)	0.6	0.8	2.3	0.8	-0.8	0.4	1.5	0.7	0.6
Alcohol drinker status: Previous	2.4	2.8	4.5	-2.1	2.1	-0.4	-0.3	-1.9	-1.9
Pack years of smoking	0.2	0.2	0.5	0.3	-0.3	0.7	0.5	0.1	0.6
Impedance of whole body	1.2	6.2	7.9	-2.8	2.8	1.1	-2.6	-2.7	-2.5
Leg fat mass (left)	0.2	0.6	2.5	0.2	-0.2	0.1	1.6	0.8	0.6
Arm predicted mass (left)	0.6	3.1	5.3	1.8	-1.9	0.6	2.3	1.6	1.9