Hub : Genes

GARNL3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.2082 0.0545 9.0e-08 0.059 NA 0.110 NA 0.093 0.00002 NA 6.4e-09 NA 9.1e-08
2 GTEx Heart Left Ventricle 0.1054 0.0544 3.4e-03 0.021 NA -0.001 NA 0.016 0.02500 NA 3.4e-01 NA 4.5e-02
3 TCGA Breast Invasive Carcinoma 0.0309 0.0144 7.1e-05 0.016 0.019 0.018 NA 0.015 0.00024 8.2e-05 9.6e-05 NA 4.2e-04
4 TCGA Lung Squamous Cell Carcinoma 0.0251 0.0159 6.1e-03 0.023 0.014 0.010 NA 0.018 0.00099 8.0e-03 2.0e-02 NA 3.7e-03
5 TCGA Prostate Adenocarcinoma 0.1251 0.0709 5.5e-03 0.008 0.013 0.030 NA 0.006 0.03900 1.6e-02 3.5e-04 NA 6.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.2 1.9 4.3 -0.8 -2.1 -1.4 -0.8 -1.5
Bipolar Disorder or Schizophrenia 0.9 2.3 5.8 -0.5 -2.4 -1.5 0.2 -1.7
Depressed Affect (Nagel 2018) 0.4 0.8 2.1 1.4 0.6 0.4 0.4 1.1
Depression (Nagel 2018) 0.6 0.9 3.1 0.3 -0.8 -0.0 1.8 -0.8
Intelligence (Savage-Jansen 2018) 1.0 3.1 5.2 0.9 -2.3 2.1 1.9 1.1
Neuroticism (Nagel 2018) 0.2 0.4 0.6 0.7 -0.8 -0.8 0.5 -0.2
Schizophrenia (2018) 0.5 0.9 2.1 -0.1 -1.4 -0.9 0.9 -1.0
Schizophrenia vs Biploar Disorder 0.2 0.3 0.6 0.2 0.6 0.7 0.8 -0.1
Worry (Nagel 2018) 0.5 1.1 2.9 -0.7 -1.0 -1.7 0.2 -1.1
Alzheimer’s Disease (in mother) 0.2 0.3 1.2 0.2 -0.2 0.0 0.3 -1.1
Alzheimer’s Disease (in father) 1.3 1.5 3.4 1.5 -0.7 1.1 1.8 0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 2.9 0.3 0.0 -0.0 0.6 -1.7
Crohns Disease (2017) 0.3 0.7 1.7 -0.3 1.3 0.1 -1.0 0.7
Irritable Bowel Disease (IBD) 0.2 0.5 1.1 -0.4 1.1 0.6 -0.8 0.5
Ulcerative Colitis (UC) 0.1 0.2 0.5 -0.2 0.7 0.7 -0.5 -0.1
Major Depression (MDD) 2.0 2.4 4.2 -2.0 -0.1 -1.8 -0.9 -2.0
Reaction Time 1.6 3.1 5.8 1.1 -2.0 2.1 2.4 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.1 1.5 0.9 -1.2 1.2 1.2 0.6
Breast Cancer 0.3 0.8 1.9 0.9 1.4 0.9 -0.3 -0.4
Ovarian Cancer 1.6 2.1 4.9 1.6 -0.2 1.6 2.2 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.2 0.5 0.1 0.7 0.5 -0.2 -0.7
Bipolar Disorder (2011) 2.8 2.7 5.0 -1.2 -1.3 -2.2 -1.1 -2.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.7 0.3 -0.4 -0.2 -0.4 0.8
Coronary Artery Disease (CAD) 1.0 1.2 3.1 0.8 1.8 0.7 0.9 -0.8
Crohns Disease (2012) 0.3 0.6 1.2 -0.2 1.1 -0.6 -1.1 -0.2
Mean Putamen Volume 0.5 0.6 2.0 0.4 -0.1 0.8 0.3 1.4
Fasting Glucose 3.7 4.4 9.7 2.0 0.7 2.4 1.5 3.1
HbA1C 0.5 0.6 1.4 0.1 -1.1 -0.5 -0.3 1.2
HDL Cholesterol 1.0 1.6 3.3 -1.8 -0.6 -1.0 -0.7 -1.8
LDL Cholesterol 0.8 1.2 2.6 0.5 0.4 1.5 0.9 1.6
Lupus 0.8 1.2 3.7 -0.4 1.9 0.0 -1.4 0.4
Neuroticism (2016) 0.3 0.4 0.7 0.2 0.2 -0.8 -0.7 -0.8
Primary Biliary Cirrhosis 0.4 0.5 0.9 -0.7 0.9 0.1 -0.5 -1.0
Rheumatoid Arthritis 2.1 2.8 4.7 -1.9 1.3 -2.1 -2.2 -0.0
Schizophrenia (2014) 1.0 2.3 4.9 -0.7 -2.2 -1.2 1.1 -1.9
Triglycerides 1.1 1.9 4.6 1.2 1.4 1.1 0.6 2.1
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.8 -0.2 -0.7 -0.6 0.2 -1.3
Ulcerative Colitis 0.2 0.3 0.6 0.4 0.5 0.8 -0.2 -0.6
Blood Eosinophil Count 0.2 1.8 5.5 -1.1 2.3 -0.8 -0.8 -0.9
Blood Platelet Count 0.2 2.7 8.3 -1.7 2.9 0.2 -0.9 -1.1
Blood Red Count 0.3 3.4 5.4 -2.3 0.4 -2.2 -1.0 -2.3
Blood White Count 0.8 5.8 14.9 -1.6 3.0 -1.0 -1.3 -3.9
Heel T-Score 1.4 10.8 31.7 2.5 -5.6 2.4 2.5 2.0
BMI 0.2 1.1 3.1 1.2 1.8 0.8 -0.3 -0.4
Height 0.3 4.9 15.8 -2.0 -4.0 1.6 1.2 0.3
Waist Hip Ratio (WHR) 0.4 1.9 4.0 -1.9 0.4 -2.0 -1.2 0.1
Systolic Blood Pressure 0.5 2.3 4.1 -2.0 0.1 -1.8 -1.8 -1.0
Smoking Status 0.2 0.5 1.2 -0.7 -0.0 -0.5 1.1 -0.8
Allergy or Eczema 0.3 0.7 1.5 1.2 0.2 1.2 0.8 -0.4
Cardiovascular Disease 0.9 3.0 8.1 -1.5 -0.3 -2.9 -1.8 -1.2
Hypothyroidism (self reported) 0.5 1.1 2.6 0.3 1.6 -0.8 -0.4 -1.3
Respiratory disease 0.3 0.7 1.6 0.8 1.3 0.8 -0.1 0.9
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.8 1.7 0.9 0.5 0.5 -0.1
Lung FEV1/FVC ratio 0.1 0.3 1.1 0.5 0.0 0.2 -0.1 1.1
Lung FVC 0.2 1.3 2.3 -1.5 -1.1 -1.3 0.6 -0.8
Neuroticism 0.1 0.3 0.9 1.0 0.3 -0.8 0.2 -0.1
Chronotype (morning person) 0.8 1.9 5.8 -0.2 1.4 -0.8 -2.4 1.1
Hair Pigment 0.4 12.4 21.3 3.2 -3.6 4.0 4.6 1.1
Tanning 0.1 0.6 1.8 0.8 0.8 0.1 -0.2 1.4
Hand grip strength (left) 0.7 2.0 4.0 -1.8 -2.0 -0.6 0.8 -1.3
Number of treatments/medications taken 0.3 0.5 1.3 -0.2 0.2 -1.1 -0.9 0.4
Average weekly spirits intake 0.3 0.4 1.5 -0.1 1.2 0.5 0.0 -0.1
Sensitivity / hurt feelings 1.1 1.9 3.8 2.0 -1.2 0.7 1.9 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.3 0.6 0.0 0.5 1.5 -1.0
Hearing difficulty/problems: Yes 0.5 0.7 2.2 -0.7 -0.5 -0.0 1.5 -0.8
Relative age of first facial hair 0.5 1.0 1.6 1.3 -0.8 0.9 0.6 1.3
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 -0.2 0.6 0.1 0.3 -0.6
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 0.4 0.5 0.7 0.7 -0.4
Ever had hysterectomy (womb removed) 0.8 0.9 1.8 0.9 -0.7 0.4 1.3 1.2
Systolic blood pressure, automated reading 0.6 1.7 4.8 -2.2 -0.1 -1.3 -0.6 -1.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.5 0.4 0.7 0.3 0.1 -0.1
Angina 0.7 0.9 2.7 -0.2 -1.6 -0.9 -1.0 -0.2
Medication for hormone replacement therapy 0.3 0.3 1.0 0.6 -1.0 0.0 0.4 -0.5
Vitamin and mineral supplements 1.1 1.5 5.9 -0.0 2.4 0.5 -0.6 1.1
Supplements: Zinc 0.4 0.4 1.2 1.1 -0.2 0.5 0.7 0.3
Medication: Co-codamol 1.5 1.7 4.4 -0.6 2.1 -0.8 -1.4 1.1
Medication: Metformin 0.5 0.7 2.3 -0.1 1.5 -0.7 -0.0 -0.7
Diabetes (father) 0.7 0.9 1.5 -1.1 0.4 -1.2 -0.8 -1.0
Diabetes (mother) 0.3 0.4 0.9 0.1 0.6 -0.6 -0.5 -0.9
Severe depression (siblings) 0.2 0.2 0.5 -0.3 -0.4 -0.2 0.7 -0.5
Pack years adult smoking proportion 0.9 1.3 3.6 -1.9 0.3 -0.9 -0.4 -1.4
Impedance of leg (right) 0.9 4.5 8.9 -3.0 -0.8 -3.0 -1.9 -0.5
Leg fat-free mass (left) 0.1 0.8 2.2 1.0 -0.2 1.5 0.7 0.5
Trunk fat percentage 0.8 3.2 7.3 -0.3 2.7 -1.4 -2.6 0.2
Hand grip strength (right) 1.1 2.9 7.6 -2.3 -0.4 -1.2 -0.2 -2.7
Townsend deprivation index at recruitment 0.4 0.5 1.1 -1.1 -0.2 -0.6 -0.2 -1.0
Current tobacco smoking 0.6 0.9 2.0 -1.4 0.7 0.2 0.7 -1.3
Average weekly fortified wine intake 2.1 2.4 4.7 -1.5 0.5 -1.9 -2.2 -1.2
Maternal smoking around birth 3.2 4.7 12.7 0.1 -3.6 0.7 3.1 -0.8
Fed-up feelings 0.5 1.0 4.0 0.6 2.0 0.7 0.2 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.4 0.1 -0.2 -0.2 0.6 -0.6
Relative age voice broke 2.6 3.9 9.9 2.9 0.0 1.2 0.3 3.1
Taking other prescription medications 0.5 0.7 1.7 0.7 0.9 -0.1 -1.3 0.7
Age when periods started (menarche) 0.8 2.0 6.2 -2.5 -0.4 -1.7 -0.6 -0.7
Bilateral oophorectomy (both ovaries removed) 4.1 4.8 10.3 2.6 -1.0 1.9 3.2 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 3.3 0.9 -1.8 0.5 0.6 1.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 -0.4 0.3 -0.7 -0.5 0.6
Qualifications: CSEs or equivalent 0.8 1.1 3.2 0.4 1.0 -0.3 -1.0 1.8
Serious illness, injury or assault to yourself 0.0 0.0 0.1 -0.3 0.0 -0.1 0.3 0.1
High blood pressure 1.1 3.0 7.4 -1.7 -1.6 -2.7 -1.2 -0.7
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.5 1.2 -0.1 1.1 0.6 0.1
Multivitamins +/- minerals 0.7 0.9 1.4 -0.2 -0.8 -1.1 -0.9 -1.2
Stomach or abdominal pain in last month 1.0 1.3 3.3 -0.5 1.8 -0.5 -1.6 -0.0
Supplements: Glucosamine 0.6 0.8 1.7 1.3 -0.7 1.0 0.9 0.3
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 0.7 1.1 0.6 0.0 1.0
Medication: Atenolol 0.6 0.8 1.8 -0.7 -1.4 -1.2 -0.5 -0.0
Medication: Levothyroxine sodium 0.6 1.1 1.8 -0.7 1.2 -1.3 -1.2 0.3
Sitting height 0.2 1.6 4.4 -1.7 -2.1 -0.5 -0.3 -0.5
Chronic bronchitis/emphysema (father) 0.7 0.9 2.7 -1.6 -0.8 -0.9 -0.3 -0.2
High blood pressure (mother) 0.4 0.5 1.0 -0.2 -1.0 -0.8 -0.4 0.8
Body mass index (BMI) 0.3 1.1 3.1 -0.4 1.8 -0.5 -1.0 -1.1
Impedance of leg (left) 0.5 2.5 5.3 -2.3 -1.2 -2.1 -1.1 -0.3
Leg predicted mass (left) 0.1 0.8 2.1 1.1 -0.1 1.5 0.6 0.4
Trunk fat mass 0.4 1.7 4.0 -0.3 2.0 -0.9 -1.9 -0.0
Waist circumference 0.2 0.8 1.3 -0.9 0.8 -0.7 -1.1 -0.7
Number of incorrect matches in round 2.4 4.0 6.2 -2.5 -2.1 -2.4 -1.5 -1.3
Past tobacco smoking 0.3 0.5 1.1 0.4 0.3 1.1 -0.6 0.8
Alcohol usually taken with meals 0.2 0.2 0.7 0.8 -0.4 0.2 -0.1 0.6
Nervous feelings 0.1 0.2 0.8 -0.4 0.0 -0.9 -0.0 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.5 1.2 -0.8 0.5 1.2 -0.3
Hearing difficulty/problems with background noise 1.8 2.9 7.5 0.3 -2.7 -0.4 1.8 -1.9
Hair/balding pattern: Pattern 2 0.3 0.4 1.2 0.3 -0.5 0.4 0.3 1.1
Had menopause 0.8 0.9 3.7 -0.3 -0.9 0.3 0.2 -1.9
Had other major operations 0.2 0.3 0.9 0.7 0.3 0.0 0.0 0.9
Forced vital capacity (FVC) 0.7 2.6 8.6 -1.0 -2.9 0.5 1.8 -0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.7 4.0 7.0 2.6 -1.6 1.8 1.8 1.9
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.2 0.3 -0.2 1.1 0.6 0.4
Qualifications: None of the above 0.1 0.3 0.9 0.4 0.2 -0.5 -0.4 1.0
Financial difficulties in last 2 years 0.3 0.4 1.0 0.5 -1.0 -0.6 0.2 0.8
Mouth/teeth dental problems 0.1 0.2 0.3 -0.5 -0.5 -0.4 -0.0 0.4
Heart attack 0.9 1.1 2.2 -0.8 0.3 -1.5 -1.4 -1.0
Allergy 0.5 1.3 4.1 -2.0 0.0 -0.8 -0.1 -1.2
Pain all over the body in last month 1.3 1.4 4.5 0.1 2.1 -0.9 -1.3 0.1
Diabetes (self-reported) 0.4 0.6 1.1 0.9 0.7 1.1 0.5 -0.1
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.2 1.8 -0.2 0.1 -0.3 1.5
Medication: Ramipril 1.3 1.6 3.7 -1.9 -0.3 -1.5 -1.5 0.1
Medication: Simvastatin 0.7 1.1 2.3 -0.2 -1.4 -1.0 -0.2 -1.5
Fluid intelligence score 0.5 1.0 3.9 -0.8 -2.0 -0.4 0.2 -0.2
Illnesses of siblings 0.6 0.8 2.2 1.1 0.8 1.5 0.2 0.2
Neuroticism score 0.5 1.1 2.5 1.6 -0.7 0.8 1.5 0.1
Weight 0.0 0.1 0.2 -0.3 0.5 0.2 -0.4 -0.3
Impedance of arm (right) 1.3 6.1 14.7 0.1 2.8 -1.8 -3.8 2.2
Arm fat percentage (right) 1.2 4.8 12.5 -0.5 3.5 -1.6 -3.0 -0.1
Trunk fat-free mass 0.5 2.6 6.5 0.1 -2.5 1.6 2.0 -0.2
Hip circumference 0.1 0.4 0.9 -0.8 0.6 -0.3 -1.0 -0.5
Time employed in main current job 1.8 2.1 5.8 1.1 -0.9 1.3 2.4 -1.1
Alcohol intake versus 10 years previously 0.4 0.6 1.6 -0.2 1.3 -0.2 -0.6 -0.9
Father’s age at death 2.1 2.8 5.2 1.9 0.2 2.3 2.1 0.7
Worrier / anxious feelings 0.4 0.7 1.7 1.0 0.5 -0.7 -0.3 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.0 0.0 -0.2 0.2 0.1 0.1 -0.1
Falls in the last year 2.2 3.0 5.5 2.0 -1.2 1.8 0.9 2.4
Hair/balding pattern: Pattern 3 1.1 1.6 4.5 -0.1 -1.7 0.7 2.1 0.3
Number of live births 2.2 3.1 7.2 -2.7 1.1 -1.9 -1.6 -0.8
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.3 -1.1 -1.5 -0.3 0.5 -0.5
Pulse rate 0.5 0.8 1.5 -1.1 -0.5 -1.2 -0.8 -0.7
Happiness 1.2 1.4 3.0 1.4 -0.7 1.7 1.0 0.7
Noisy workplace 0.7 0.9 2.6 0.1 1.6 1.1 -0.0 0.7
Qualifications: A levels/AS levels or equivalent 0.8 1.7 2.6 1.6 -1.5 1.6 0.8 0.7
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 5.6 0.3 -2.1 0.5 2.4 1.2
Mouth/teeth dental problems: Dentures 0.8 1.4 3.7 -1.0 1.9 -0.4 -1.1 -1.0
Asthma 0.9 1.7 5.3 1.5 0.2 0.8 -0.1 2.3
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.6 3.8 1.2 -2.0 0.4 1.4 0.7
Medication: Cholesterol lowering 0.3 0.4 1.2 -0.0 -0.4 -1.1 -0.9 -0.1
Depression (self-reported) 1.1 1.3 2.2 0.3 1.5 -1.3 -0.8 -1.4
Medication: Lansoprazole 1.9 2.2 3.9 -1.8 0.7 -1.8 -2.0 -0.2
Prospective memory result 0.9 1.1 4.9 0.5 2.2 -0.5 -0.4 -0.1
Lung cancer (father) 0.2 0.2 0.5 0.7 0.3 0.2 0.5 -0.2
Illnesses of mother 0.1 0.1 0.2 -0.2 -0.3 0.5 -0.1 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 5.0 -0.5 -2.2 0.3 1.3 0.5
Pulse wave Arterial Stiffness index 0.4 0.4 1.6 0.5 0.0 0.7 0.1 1.3
Impedance of arm (left) 0.7 3.4 7.3 0.7 1.8 -1.3 -2.7 2.1
Arm fat mass (right) 0.3 1.4 3.7 -0.3 1.9 -0.6 -1.6 -0.5
Trunk predicted mass 0.5 2.7 6.6 0.2 -2.6 1.6 2.1 -0.3
Standing height 0.3 2.6 7.8 0.1 -2.8 1.4 1.3 1.3
Length of working week for main job 0.7 0.8 3.0 0.6 1.7 0.2 -0.7 -0.1
Exposure to tobacco smoke at home 1.6 1.8 5.4 -2.3 0.9 -1.6 -0.6 0.1
Breastfed as a baby 0.9 1.1 2.2 0.6 -1.5 1.0 1.1 0.8
Tense / ‘highly strung’ 1.8 3.0 6.7 -2.2 -1.1 -1.5 -0.0 -2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.7 0.4 0.3 -0.1 -0.8
Hair/balding pattern: Pattern 4 1.2 3.0 5.4 -0.9 0.5 -2.3 -2.2 -1.9
Birth weight of first child 2.2 4.0 7.5 -2.4 1.0 -2.2 -2.7 -1.0
Peak expiratory flow (PEF) 0.9 2.1 3.5 -1.9 0.3 -1.6 -1.7 -1.3
Pulse wave reflection index 1.2 1.5 2.9 1.7 0.4 1.4 1.1 1.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.5 -0.8 -0.2 -1.6 -0.8 -0.4
Loud music exposure frequency 1.4 1.5 3.5 1.2 -1.0 1.9 0.9 -0.9
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 3.4 0.9 -0.9 1.6 1.7 1.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.2 0.4 -0.4 -0.4 0.1 -0.0
Blood clot in the leg (DVT) 0.4 0.5 1.6 0.4 1.3 -0.2 -0.5 0.7
Medication: Paracetamol 0.3 0.6 2.1 0.5 1.4 -0.0 -0.7 0.0
Headache pain in last month 0.5 0.8 2.2 0.6 0.8 1.5 1.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.0 -0.5 1.4 0.7 0.5 -0.5
Glaucoma (self-reported) 1.4 1.6 3.3 0.9 -1.4 1.4 1.8 0.2
Gout (self-reported) 1.1 1.6 3.1 -0.7 -0.3 -1.0 -1.8 -1.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.8 0.3 1.0 -0.9 -1.3 -0.6
Medication: Amlodipine 0.8 1.1 2.0 -0.5 -1.3 -1.2 0.2 1.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.1 -0.4 0.7 -1.1 -0.2 -0.5
Birth weight 0.2 0.5 1.7 0.6 1.3 0.2 -0.3 0.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.5 0.3 -0.6 -0.4 1.1 -1.2
High blood pressure (siblings) 0.2 0.3 0.5 -0.3 -0.5 -0.7 0.7 0.2
Forced vital capacity (FVC), Best measure 0.8 2.8 10.0 -0.6 -3.2 0.2 1.8 0.2
Body fat percentage 0.8 3.0 6.2 -0.7 2.3 -1.6 -2.5 -0.2
Leg fat percentage (right) 1.1 4.1 6.0 -2.3 1.4 -2.5 -2.4 -1.2
Arm fat-free mass (right) 0.5 2.3 4.6 -0.1 -2.1 1.6 2.0 -0.8
Exposure to tobacco smoke outside home 1.2 1.6 3.5 0.7 -1.6 0.9 1.9 0.7
Comparative body size at age 10 0.7 2.0 4.6 1.7 0.8 -0.3 -1.3 2.1
Number of full brothers 1.7 2.1 4.0 -2.0 -0.5 -1.8 -0.0 -1.7
Worry too long after embarrassment 3.5 5.9 11.0 3.3 -0.5 3.0 3.0 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.4 0.7 -0.5 0.2 -0.0
Wheeze or whistling in the chest in last year 0.3 0.5 1.5 -0.4 1.2 -0.7 -0.6 0.0
Number of children fathered 2.6 3.0 5.3 -1.4 1.3 -2.3 -2.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.2 7.2 -0.0 -2.7 -0.6 0.7 -1.7
Age at first live birth 1.2 2.2 4.1 0.9 -1.8 1.6 2.0 -0.4
Pulse wave peak to peak time 0.6 0.7 2.1 -0.7 -0.4 -0.7 0.0 -1.5
Health satisfaction 0.1 0.2 0.3 0.5 0.1 0.5 0.5 0.3
Shortness of breath walking on level ground 0.6 0.7 1.3 1.2 0.0 0.8 0.9 0.9
Qualifications: College or University degree 0.1 0.3 0.9 0.3 -0.5 0.9 0.5 -0.1
Eye problems/disorders: None of the above 0.7 0.8 2.6 1.6 -0.7 0.7 0.5 0.5
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 -0.2 -0.2 -0.4 0.4 0.5
Emphysema/chronic bronchitis 0.6 0.7 2.4 1.6 0.2 0.6 0.7 -0.4
Medication for pain relief, constipation, heartburn 0.2 0.3 0.9 0.1 0.2 0.9 0.6 0.3
Neck or shoulder pain in last month 0.3 0.4 1.0 0.1 -0.4 0.4 0.7 1.0
Medication: Blood pressure 0.3 0.6 2.0 0.5 -1.4 -0.7 -0.4 0.2
Angina (self-reported) 0.7 0.9 2.2 -0.3 -1.5 -1.1 -0.8 -0.7
Migraine (self-reported) 1.3 1.6 2.9 0.6 0.5 1.7 1.4 1.5
Medication: Ibuprofen 1.0 1.2 2.8 1.7 -0.9 0.5 0.9 1.1
Medication: Allopurinol 0.5 0.7 1.7 0.1 -1.3 -0.3 -1.2 -0.4
Medication: Omeprazole 0.2 0.2 0.7 -0.3 0.4 0.8 0.1 0.5
Medication: Seretide 50 evohaler 1.3 1.5 4.2 2.0 0.1 1.2 0.6 1.1
Mean time to correctly identify matches 2.2 4.2 7.1 1.6 -2.1 2.7 2.7 -0.3
Heart disease (mother) 0.5 0.6 1.0 0.9 -0.9 -0.0 0.5 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.2 -0.7 -0.7 0.3 0.7 -1.1
Whole body fat mass 0.3 1.4 2.9 -0.6 1.7 -1.0 -1.7 -0.4
Leg fat mass (right) 0.4 1.5 2.3 -1.4 1.1 -1.2 -1.5 -0.9
Arm predicted mass (right) 0.5 2.6 5.6 -0.2 -2.4 1.5 2.1 -0.9
Pulse rate, automated reading 1.9 6.1 8.8 -3.0 2.3 -2.3 -2.9 -1.7
Alcohol intake frequency. 2.9 6.7 14.7 -3.0 1.8 -2.6 -3.8 -0.3
Comparative height size at age 10 0.2 1.1 2.0 -1.3 -1.4 -0.3 -1.0 0.9
Number of full sisters 2.5 3.1 7.2 -2.7 0.0 -2.3 -0.8 -1.5
Suffer from ‘nerves’ 2.5 3.9 7.4 -2.1 1.1 -1.9 -1.5 -2.7
Overall health rating 0.6 1.2 2.9 -0.8 1.7 -0.9 -1.1 -0.7
Chest pain or discomfort 0.3 0.4 0.7 0.1 -0.6 -0.7 -0.8 0.8
Had major operations 1.1 1.3 3.3 0.7 1.1 -0.9 -1.8 0.9
Age at last live birth 1.0 1.4 2.2 -1.3 -1.4 -1.1 0.1 -1.5
Family relationship satisfaction 1.4 1.7 4.4 2.1 -0.2 1.2 0.8 1.4
Leg pain on walking 0.2 0.2 0.6 -0.1 0.3 -0.6 0.0 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.0 0.2 0.8 -0.8 -1.4 0.5
Commuting to job workplace: Car/motor vehicle 0.4 0.5 2.0 -1.4 0.2 0.0 0.0 -0.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.3 1.0 1.1 1.0 0.2 -1.1
Medication: Aspirin 0.2 0.2 0.5 0.4 -0.7 -0.4 0.1 -0.5
Supplements: Vitamin C 4.8 5.7 14.2 2.0 -3.8 0.6 3.0 0.8
Knee pain experienced in last month 0.3 0.5 1.9 0.2 -1.4 -0.5 -0.1 0.5
Hypertension (Self-reported) 1.1 3.1 7.3 -1.9 -1.1 -2.7 -1.5 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.6 -0.8 -0.5 0.2 -0.6 -0.2
Illnesses of father: Heart disease 0.9 1.3 2.3 0.1 1.2 -1.0 -1.5 1.4
Illnesses of siblings: Diabetes 0.3 0.4 1.2 -0.2 -1.1 -0.5 0.6 -0.3
Smoking status: Previous 0.3 0.4 1.2 0.7 -0.3 -1.1 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 -0.4 -1.1 0.8 1.3 -0.8
Whole body fat-free mass 0.3 1.7 3.0 0.5 -1.7 1.7 1.6 -0.1
Leg fat-free mass (right) 0.3 1.7 4.3 1.5 -0.4 2.1 1.2 0.7
Arm fat percentage (left) 0.9 3.5 9.7 -0.2 3.1 -1.2 -2.5 -0.1
Average weekly red wine intake 2.7 4.0 11.6 1.6 -3.4 1.5 1.8 -0.0
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 0.4 0.1 -0.2 -0.1 -0.2
Mood swings 0.7 1.3 2.9 1.7 0.0 1.0 1.4 0.7
Loneliness, isolation 0.4 0.5 1.7 -0.0 -0.4 -1.3 -0.6 -0.6
Long-standing illness, disability or infirmity 0.2 0.3 0.6 0.2 0.8 0.1 0.4 -0.6
Ever had bowel cancer screening 1.2 1.4 3.8 -0.6 -2.0 -1.4 -0.1 0.8
Diabetes diagnosed by doctor 0.2 0.3 0.8 0.4 0.9 0.4 0.1 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.4 0.2 -1.2 -0.1 0.2 0.4
Friendships satisfaction 0.8 0.9 1.7 1.1 -0.7 1.3 1.0 -0.6
Qualifications: nursing, teaching 0.2 0.3 0.6 0.7 0.0 0.5 -0.0 -0.7
Commuting to job workplace: Walk 0.5 0.5 1.2 0.4 -1.1 -0.5 -0.8 0.3
Eye problems/disorders: Cataract 0.5 0.5 1.6 -1.0 1.2 0.0 -0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 5.3 2.3 -1.2 1.8 1.3 1.4
Medication for cholesterol 1.8 2.7 6.4 1.9 0.7 2.5 0.7 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 3.1 -0.6 1.3 -1.8 -0.9 -0.3
Back pain experienced in last month 1.0 1.5 5.1 -0.6 -2.3 -0.7 -0.0 1.2
Mineral and other dietary supplements 0.3 0.4 1.6 -1.3 0.3 -0.4 0.1 -0.2
Breast cancer (self-reported) 1.1 1.4 3.3 1.2 0.8 1.1 0.5 1.8
Asthma (self-reported) 0.9 1.8 4.9 1.7 0.2 1.0 0.1 2.2
Osteoporosis (self-reported) 0.2 0.3 0.7 -0.8 0.3 -0.3 0.2 0.8
Osteoarthritis (self-reported) 3.6 4.7 6.2 -2.0 2.2 -2.0 -2.5 -2.1
Medication: Aspirin 0.3 0.3 0.9 -0.1 -0.6 -0.9 -0.4 -0.5
Medication: Gliclazide 0.7 0.7 1.7 1.1 1.3 0.8 0.1 -0.5
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 0.6 0.5 1.1 0.6 0.5
Smoking status: Current 0.6 0.9 3.0 -1.7 0.6 0.3 0.6 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.0 -0.7 -1.4 -0.9 0.8 -0.3
Whole body water mass 0.3 1.8 3.2 0.4 -1.8 1.7 1.6 -0.2
Leg predicted mass (right) 0.3 1.7 4.3 1.5 -0.4 2.1 1.1 0.6
Arm fat mass (left) 0.3 1.4 3.2 -0.5 1.8 -0.8 -1.6 -0.5
Number of self-reported non-cancer illnesses 0.2 0.3 1.0 0.5 -0.4 0.3 0.3 1.0
Average weekly champagne plus white wine intake 3.8 5.2 7.9 2.0 -1.6 2.1 2.6 2.8
Miserableness 0.4 0.7 2.3 0.7 0.7 0.2 -0.3 1.5
Guilty feelings 0.6 0.9 1.6 1.1 -1.0 0.7 1.3 0.4
Wears glasses or contact lenses 0.2 0.2 0.4 0.2 -0.6 0.3 -0.4 0.6
Ever taken oral contraceptive pill 0.8 0.9 4.0 2.0 0.6 0.3 -0.0 -0.4
Hearing aid user 0.6 0.7 2.0 -0.1 0.8 -0.7 -0.4 -1.4
Mother’s age at death 0.2 0.2 0.8 0.3 -0.1 0.5 -0.2 -0.9
Financial situation satisfaction 0.4 0.6 1.2 -0.6 1.1 -0.4 -1.0 -0.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.3 -0.5 0.0 0.5 0.2
Commuting to job workplace: Public transport 0.7 0.8 3.4 1.8 0.4 0.6 0.2 0.4
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 0.6 -0.8 0.8 1.0 -0.4
Medication: Blood pressure 3.6 6.9 17.1 -3.1 0.0 -4.1 -2.4 -1.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.6 -0.8 -0.4 -0.5 0.1 0.3
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.4 1.9 -0.6 0.5 0.6 0.9
High cholesterol (Self-reported) 0.2 0.3 0.6 0.6 -0.7 -0.1 0.8 -0.2
Medication: Bendroflumethiazide 2.2 3.4 6.8 -1.2 2.3 -2.6 -1.5 -1.1
Medication: Paracetamol 0.5 0.8 2.9 0.1 1.7 -0.3 -0.9 0.1
Medication: Lisinopril 0.8 1.0 1.8 1.4 -0.1 1.3 1.2 0.1
Medication: Atorvastatin 0.8 0.9 2.3 1.0 -1.0 0.4 0.6 1.5
Illnesses of father: High blood pressure 1.1 1.4 3.0 -1.3 -0.4 -1.7 -0.9 -1.1
Alcohol drinker status: Never 0.8 1.0 3.1 -1.0 0.2 -0.9 -1.8 -0.0
Ever smoked 0.3 0.5 1.0 -0.3 -0.8 -0.7 1.0 -0.7
Basal metabolic rate 0.1 0.8 1.5 0.2 -1.1 1.2 1.1 -0.2
Leg fat percentage (left) 0.6 2.3 3.2 -1.6 1.5 -1.6 -1.8 -1.0
Arm fat-free mass (left) 0.3 1.5 3.5 -0.6 -1.9 0.9 1.4 -0.9
Number of operations (self-reported) 0.7 1.1 2.2 0.2 -0.1 -1.4 -1.1 1.5
Average weekly beer plus cider intake 1.4 2.0 3.7 0.1 -1.9 1.6 1.9 -0.7
Irritability 0.5 0.8 1.9 1.2 0.1 1.4 0.9 -0.2
Risk taking 1.3 2.0 5.1 0.5 -2.3 0.1 1.3 1.6
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.5 0.7 0.1 0.1 0.1 -0.1
Fractured/broken bones in last 5 years 2.1 2.7 9.7 0.4 -1.4 0.3 -1.2 3.1
Age started oral contraceptive pill 0.7 0.8 2.5 0.3 -1.6 1.0 0.2 0.7
Diastolic blood pressure, automated reading 1.1 3.5 5.5 -2.3 1.6 -2.2 -1.1 -1.9
Ever depressed for a whole week 0.7 0.8 1.8 0.1 -1.4 0.7 1.3 0.5
Unable to work because of sickness or disability 1.5 1.9 3.9 -1.3 2.0 -1.4 -1.3 -0.4
Commuting to job workplace: Cycle 6.7 8.1 14.3 3.8 -2.0 3.1 2.6 2.4
Myopia 0.9 1.3 2.3 1.4 -0.6 1.3 1.5 0.3
Vascular/heart problems diagnosed by doctor 1.0 2.6 6.2 1.4 1.6 2.5 1.3 0.6
Cholesterol lowering medication 1.0 1.4 3.3 1.1 -1.5 0.5 1.8 0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.7 -0.9 0.6 0.3 -0.3 0.6
Pain experienced in last month 0.4 0.6 1.4 -0.5 0.9 -0.4 -0.7 -1.2
Supplements: Calcium 0.4 0.4 1.6 1.3 0.3 -0.0 0.4 -0.6
Basal cell carcinoma (self-reported) 0.7 0.8 2.0 -0.8 -0.2 -1.4 -0.5 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 2.2 -0.7 0.3 -1.5 -1.4 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.7 0.4 1.3 -0.2 -0.4 0.5
Heart disease (siblings) 0.2 0.3 0.9 -0.4 -0.7 -0.9 0.0 -0.0
Alcohol drinker status: Previous 1.4 1.6 4.9 0.3 -1.5 0.4 0.8 2.2
Pack years of smoking 0.8 1.2 3.4 -1.9 0.4 -0.9 -0.6 -1.1
Impedance of whole body 0.5 2.8 6.8 -0.9 0.9 -2.0 -2.6 1.1
Leg fat mass (left) 0.3 1.0 1.4 -1.1 1.1 -0.8 -1.2 -0.8
Arm predicted mass (left) 0.3 1.6 3.6 -0.5 -1.9 1.0 1.4 -0.9