Hub : Genes

GARNL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2082	0.0545	9.0e-08	0.059	NA	0.110	NA	0.093	0.00002	NA	6.4e-09	NA	9.1e-08
2	GTEx	Heart Left Ventricle	0.1054	0.0544	3.4e-03	0.021	NA	-0.001	NA	0.016	0.02500	NA	3.4e-01	NA	4.5e-02
3	TCGA	Breast Invasive Carcinoma	0.0309	0.0144	7.1e-05	0.016	0.019	0.018	NA	0.015	0.00024	8.2e-05	9.6e-05	NA	4.2e-04
4	TCGA	Lung Squamous Cell Carcinoma	0.0251	0.0159	6.1e-03	0.023	0.014	0.010	NA	0.018	0.00099	8.0e-03	2.0e-02	NA	3.7e-03
5	TCGA	Prostate Adenocarcinoma	0.1251	0.0709	5.5e-03	0.008	0.013	0.030	NA	0.006	0.03900	1.6e-02	3.5e-04	NA	6.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	4.3	-0.8	-2.1	-1.4	-0.8	-1.5
Bipolar Disorder or Schizophrenia	0.9	2.3	5.8	-0.5	-2.4	-1.5	0.2	-1.7
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	1.4	0.6	0.4	0.4	1.1
Depression (Nagel 2018)	0.6	0.9	3.1	0.3	-0.8	-0.0	1.8	-0.8
Intelligence (Savage-Jansen 2018)	1.0	3.1	5.2	0.9	-2.3	2.1	1.9	1.1
Neuroticism (Nagel 2018)	0.2	0.4	0.6	0.7	-0.8	-0.8	0.5	-0.2
Schizophrenia (2018)	0.5	0.9	2.1	-0.1	-1.4	-0.9	0.9	-1.0
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	0.2	0.6	0.7	0.8	-0.1
Worry (Nagel 2018)	0.5	1.1	2.9	-0.7	-1.0	-1.7	0.2	-1.1
Alzheimer’s Disease (in mother)	0.2	0.3	1.2	0.2	-0.2	0.0	0.3	-1.1
Alzheimer’s Disease (in father)	1.3	1.5	3.4	1.5	-0.7	1.1	1.8	0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	2.9	0.3	0.0	-0.0	0.6	-1.7
Crohns Disease (2017)	0.3	0.7	1.7	-0.3	1.3	0.1	-1.0	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	-0.4	1.1	0.6	-0.8	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.2	0.7	0.7	-0.5	-0.1
Major Depression (MDD)	2.0	2.4	4.2	-2.0	-0.1	-1.8	-0.9	-2.0
Reaction Time	1.6	3.1	5.8	1.1	-2.0	2.1	2.4	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.5	0.9	-1.2	1.2	1.2	0.6
Breast Cancer	0.3	0.8	1.9	0.9	1.4	0.9	-0.3	-0.4
Ovarian Cancer	1.6	2.1	4.9	1.6	-0.2	1.6	2.2	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.2	0.5	0.1	0.7	0.5	-0.2	-0.7
Bipolar Disorder (2011)	2.8	2.7	5.0	-1.2	-1.3	-2.2	-1.1	-2.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	0.3	-0.4	-0.2	-0.4	0.8
Coronary Artery Disease (CAD)	1.0	1.2	3.1	0.8	1.8	0.7	0.9	-0.8
Crohns Disease (2012)	0.3	0.6	1.2	-0.2	1.1	-0.6	-1.1	-0.2
Mean Putamen Volume	0.5	0.6	2.0	0.4	-0.1	0.8	0.3	1.4
Fasting Glucose	3.7	4.4	9.7	2.0	0.7	2.4	1.5	3.1
HbA1C	0.5	0.6	1.4	0.1	-1.1	-0.5	-0.3	1.2
HDL Cholesterol	1.0	1.6	3.3	-1.8	-0.6	-1.0	-0.7	-1.8
LDL Cholesterol	0.8	1.2	2.6	0.5	0.4	1.5	0.9	1.6
Lupus	0.8	1.2	3.7	-0.4	1.9	0.0	-1.4	0.4
Neuroticism (2016)	0.3	0.4	0.7	0.2	0.2	-0.8	-0.7	-0.8
Primary Biliary Cirrhosis	0.4	0.5	0.9	-0.7	0.9	0.1	-0.5	-1.0
Rheumatoid Arthritis	2.1	2.8	4.7	-1.9	1.3	-2.1	-2.2	-0.0
Schizophrenia (2014)	1.0	2.3	4.9	-0.7	-2.2	-1.2	1.1	-1.9
Triglycerides	1.1	1.9	4.6	1.2	1.4	1.1	0.6	2.1
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.8	-0.2	-0.7	-0.6	0.2	-1.3
Ulcerative Colitis	0.2	0.3	0.6	0.4	0.5	0.8	-0.2	-0.6
Blood Eosinophil Count	0.2	1.8	5.5	-1.1	2.3	-0.8	-0.8	-0.9
Blood Platelet Count	0.2	2.7	8.3	-1.7	2.9	0.2	-0.9	-1.1
Blood Red Count	0.3	3.4	5.4	-2.3	0.4	-2.2	-1.0	-2.3
Blood White Count	0.8	5.8	14.9	-1.6	3.0	-1.0	-1.3	-3.9
Heel T-Score	1.4	10.8	31.7	2.5	-5.6	2.4	2.5	2.0
BMI	0.2	1.1	3.1	1.2	1.8	0.8	-0.3	-0.4
Height	0.3	4.9	15.8	-2.0	-4.0	1.6	1.2	0.3
Waist Hip Ratio (WHR)	0.4	1.9	4.0	-1.9	0.4	-2.0	-1.2	0.1
Systolic Blood Pressure	0.5	2.3	4.1	-2.0	0.1	-1.8	-1.8	-1.0
Smoking Status	0.2	0.5	1.2	-0.7	-0.0	-0.5	1.1	-0.8
Allergy or Eczema	0.3	0.7	1.5	1.2	0.2	1.2	0.8	-0.4
Cardiovascular Disease	0.9	3.0	8.1	-1.5	-0.3	-2.9	-1.8	-1.2
Hypothyroidism (self reported)	0.5	1.1	2.6	0.3	1.6	-0.8	-0.4	-1.3
Respiratory disease	0.3	0.7	1.6	0.8	1.3	0.8	-0.1	0.9
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.8	1.7	0.9	0.5	0.5	-0.1
Lung FEV1/FVC ratio	0.1	0.3	1.1	0.5	0.0	0.2	-0.1	1.1
Lung FVC	0.2	1.3	2.3	-1.5	-1.1	-1.3	0.6	-0.8
Neuroticism	0.1	0.3	0.9	1.0	0.3	-0.8	0.2	-0.1
Chronotype (morning person)	0.8	1.9	5.8	-0.2	1.4	-0.8	-2.4	1.1
Hair Pigment	0.4	12.4	21.3	3.2	-3.6	4.0	4.6	1.1
Tanning	0.1	0.6	1.8	0.8	0.8	0.1	-0.2	1.4
Hand grip strength (left)	0.7	2.0	4.0	-1.8	-2.0	-0.6	0.8	-1.3
Number of treatments/medications taken	0.3	0.5	1.3	-0.2	0.2	-1.1	-0.9	0.4
Average weekly spirits intake	0.3	0.4	1.5	-0.1	1.2	0.5	0.0	-0.1
Sensitivity / hurt feelings	1.1	1.9	3.8	2.0	-1.2	0.7	1.9	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.3	0.6	0.0	0.5	1.5	-1.0
Hearing difficulty/problems: Yes	0.5	0.7	2.2	-0.7	-0.5	-0.0	1.5	-0.8
Relative age of first facial hair	0.5	1.0	1.6	1.3	-0.8	0.9	0.6	1.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.2	0.6	0.1	0.3	-0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.4	0.5	0.7	0.7	-0.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	0.9	-0.7	0.4	1.3	1.2
Systolic blood pressure, automated reading	0.6	1.7	4.8	-2.2	-0.1	-1.3	-0.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	0.4	0.7	0.3	0.1	-0.1
Angina	0.7	0.9	2.7	-0.2	-1.6	-0.9	-1.0	-0.2
Medication for hormone replacement therapy	0.3	0.3	1.0	0.6	-1.0	0.0	0.4	-0.5
Vitamin and mineral supplements	1.1	1.5	5.9	-0.0	2.4	0.5	-0.6	1.1
Supplements: Zinc	0.4	0.4	1.2	1.1	-0.2	0.5	0.7	0.3
Medication: Co-codamol	1.5	1.7	4.4	-0.6	2.1	-0.8	-1.4	1.1
Medication: Metformin	0.5	0.7	2.3	-0.1	1.5	-0.7	-0.0	-0.7
Diabetes (father)	0.7	0.9	1.5	-1.1	0.4	-1.2	-0.8	-1.0
Diabetes (mother)	0.3	0.4	0.9	0.1	0.6	-0.6	-0.5	-0.9
Severe depression (siblings)	0.2	0.2	0.5	-0.3	-0.4	-0.2	0.7	-0.5
Pack years adult smoking proportion	0.9	1.3	3.6	-1.9	0.3	-0.9	-0.4	-1.4
Impedance of leg (right)	0.9	4.5	8.9	-3.0	-0.8	-3.0	-1.9	-0.5
Leg fat-free mass (left)	0.1	0.8	2.2	1.0	-0.2	1.5	0.7	0.5
Trunk fat percentage	0.8	3.2	7.3	-0.3	2.7	-1.4	-2.6	0.2
Hand grip strength (right)	1.1	2.9	7.6	-2.3	-0.4	-1.2	-0.2	-2.7
Townsend deprivation index at recruitment	0.4	0.5	1.1	-1.1	-0.2	-0.6	-0.2	-1.0
Current tobacco smoking	0.6	0.9	2.0	-1.4	0.7	0.2	0.7	-1.3
Average weekly fortified wine intake	2.1	2.4	4.7	-1.5	0.5	-1.9	-2.2	-1.2
Maternal smoking around birth	3.2	4.7	12.7	0.1	-3.6	0.7	3.1	-0.8
Fed-up feelings	0.5	1.0	4.0	0.6	2.0	0.7	0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.1	-0.2	-0.2	0.6	-0.6
Relative age voice broke	2.6	3.9	9.9	2.9	0.0	1.2	0.3	3.1
Taking other prescription medications	0.5	0.7	1.7	0.7	0.9	-0.1	-1.3	0.7
Age when periods started (menarche)	0.8	2.0	6.2	-2.5	-0.4	-1.7	-0.6	-0.7
Bilateral oophorectomy (both ovaries removed)	4.1	4.8	10.3	2.6	-1.0	1.9	3.2	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.3	0.9	-1.8	0.5	0.6	1.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	-0.4	0.3	-0.7	-0.5	0.6
Qualifications: CSEs or equivalent	0.8	1.1	3.2	0.4	1.0	-0.3	-1.0	1.8
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.3	0.0	-0.1	0.3	0.1
High blood pressure	1.1	3.0	7.4	-1.7	-1.6	-2.7	-1.2	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	1.2	-0.1	1.1	0.6	0.1
Multivitamins +/- minerals	0.7	0.9	1.4	-0.2	-0.8	-1.1	-0.9	-1.2
Stomach or abdominal pain in last month	1.0	1.3	3.3	-0.5	1.8	-0.5	-1.6	-0.0
Supplements: Glucosamine	0.6	0.8	1.7	1.3	-0.7	1.0	0.9	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	0.7	1.1	0.6	0.0	1.0
Medication: Atenolol	0.6	0.8	1.8	-0.7	-1.4	-1.2	-0.5	-0.0
Medication: Levothyroxine sodium	0.6	1.1	1.8	-0.7	1.2	-1.3	-1.2	0.3
Sitting height	0.2	1.6	4.4	-1.7	-2.1	-0.5	-0.3	-0.5
Chronic bronchitis/emphysema (father)	0.7	0.9	2.7	-1.6	-0.8	-0.9	-0.3	-0.2
High blood pressure (mother)	0.4	0.5	1.0	-0.2	-1.0	-0.8	-0.4	0.8
Body mass index (BMI)	0.3	1.1	3.1	-0.4	1.8	-0.5	-1.0	-1.1
Impedance of leg (left)	0.5	2.5	5.3	-2.3	-1.2	-2.1	-1.1	-0.3
Leg predicted mass (left)	0.1	0.8	2.1	1.1	-0.1	1.5	0.6	0.4
Trunk fat mass	0.4	1.7	4.0	-0.3	2.0	-0.9	-1.9	-0.0
Waist circumference	0.2	0.8	1.3	-0.9	0.8	-0.7	-1.1	-0.7
Number of incorrect matches in round	2.4	4.0	6.2	-2.5	-2.1	-2.4	-1.5	-1.3
Past tobacco smoking	0.3	0.5	1.1	0.4	0.3	1.1	-0.6	0.8
Alcohol usually taken with meals	0.2	0.2	0.7	0.8	-0.4	0.2	-0.1	0.6
Nervous feelings	0.1	0.2	0.8	-0.4	0.0	-0.9	-0.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.5	1.2	-0.8	0.5	1.2	-0.3
Hearing difficulty/problems with background noise	1.8	2.9	7.5	0.3	-2.7	-0.4	1.8	-1.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	0.3	-0.5	0.4	0.3	1.1
Had menopause	0.8	0.9	3.7	-0.3	-0.9	0.3	0.2	-1.9
Had other major operations	0.2	0.3	0.9	0.7	0.3	0.0	0.0	0.9
Forced vital capacity (FVC)	0.7	2.6	8.6	-1.0	-2.9	0.5	1.8	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	7.0	2.6	-1.6	1.8	1.8	1.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.3	-0.2	1.1	0.6	0.4
Qualifications: None of the above	0.1	0.3	0.9	0.4	0.2	-0.5	-0.4	1.0
Financial difficulties in last 2 years	0.3	0.4	1.0	0.5	-1.0	-0.6	0.2	0.8
Mouth/teeth dental problems	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.0	0.4
Heart attack	0.9	1.1	2.2	-0.8	0.3	-1.5	-1.4	-1.0
Allergy	0.5	1.3	4.1	-2.0	0.0	-0.8	-0.1	-1.2
Pain all over the body in last month	1.3	1.4	4.5	0.1	2.1	-0.9	-1.3	0.1
Diabetes (self-reported)	0.4	0.6	1.1	0.9	0.7	1.1	0.5	-0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.2	1.8	-0.2	0.1	-0.3	1.5
Medication: Ramipril	1.3	1.6	3.7	-1.9	-0.3	-1.5	-1.5	0.1
Medication: Simvastatin	0.7	1.1	2.3	-0.2	-1.4	-1.0	-0.2	-1.5
Fluid intelligence score	0.5	1.0	3.9	-0.8	-2.0	-0.4	0.2	-0.2
Illnesses of siblings	0.6	0.8	2.2	1.1	0.8	1.5	0.2	0.2
Neuroticism score	0.5	1.1	2.5	1.6	-0.7	0.8	1.5	0.1
Weight	0.0	0.1	0.2	-0.3	0.5	0.2	-0.4	-0.3
Impedance of arm (right)	1.3	6.1	14.7	0.1	2.8	-1.8	-3.8	2.2
Arm fat percentage (right)	1.2	4.8	12.5	-0.5	3.5	-1.6	-3.0	-0.1
Trunk fat-free mass	0.5	2.6	6.5	0.1	-2.5	1.6	2.0	-0.2
Hip circumference	0.1	0.4	0.9	-0.8	0.6	-0.3	-1.0	-0.5
Time employed in main current job	1.8	2.1	5.8	1.1	-0.9	1.3	2.4	-1.1
Alcohol intake versus 10 years previously	0.4	0.6	1.6	-0.2	1.3	-0.2	-0.6	-0.9
Father’s age at death	2.1	2.8	5.2	1.9	0.2	2.3	2.1	0.7
Worrier / anxious feelings	0.4	0.7	1.7	1.0	0.5	-0.7	-0.3	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	-0.2	0.2	0.1	0.1	-0.1
Falls in the last year	2.2	3.0	5.5	2.0	-1.2	1.8	0.9	2.4
Hair/balding pattern: Pattern 3	1.1	1.6	4.5	-0.1	-1.7	0.7	2.1	0.3
Number of live births	2.2	3.1	7.2	-2.7	1.1	-1.9	-1.6	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.3	-1.1	-1.5	-0.3	0.5	-0.5
Pulse rate	0.5	0.8	1.5	-1.1	-0.5	-1.2	-0.8	-0.7
Happiness	1.2	1.4	3.0	1.4	-0.7	1.7	1.0	0.7
Noisy workplace	0.7	0.9	2.6	0.1	1.6	1.1	-0.0	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.6	1.6	-1.5	1.6	0.8	0.7
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	5.6	0.3	-2.1	0.5	2.4	1.2
Mouth/teeth dental problems: Dentures	0.8	1.4	3.7	-1.0	1.9	-0.4	-1.1	-1.0
Asthma	0.9	1.7	5.3	1.5	0.2	0.8	-0.1	2.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	3.8	1.2	-2.0	0.4	1.4	0.7
Medication: Cholesterol lowering	0.3	0.4	1.2	-0.0	-0.4	-1.1	-0.9	-0.1
Depression (self-reported)	1.1	1.3	2.2	0.3	1.5	-1.3	-0.8	-1.4
Medication: Lansoprazole	1.9	2.2	3.9	-1.8	0.7	-1.8	-2.0	-0.2
Prospective memory result	0.9	1.1	4.9	0.5	2.2	-0.5	-0.4	-0.1
Lung cancer (father)	0.2	0.2	0.5	0.7	0.3	0.2	0.5	-0.2
Illnesses of mother	0.1	0.1	0.2	-0.2	-0.3	0.5	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.0	-0.5	-2.2	0.3	1.3	0.5
Pulse wave Arterial Stiffness index	0.4	0.4	1.6	0.5	0.0	0.7	0.1	1.3
Impedance of arm (left)	0.7	3.4	7.3	0.7	1.8	-1.3	-2.7	2.1
Arm fat mass (right)	0.3	1.4	3.7	-0.3	1.9	-0.6	-1.6	-0.5
Trunk predicted mass	0.5	2.7	6.6	0.2	-2.6	1.6	2.1	-0.3
Standing height	0.3	2.6	7.8	0.1	-2.8	1.4	1.3	1.3
Length of working week for main job	0.7	0.8	3.0	0.6	1.7	0.2	-0.7	-0.1
Exposure to tobacco smoke at home	1.6	1.8	5.4	-2.3	0.9	-1.6	-0.6	0.1
Breastfed as a baby	0.9	1.1	2.2	0.6	-1.5	1.0	1.1	0.8
Tense / ‘highly strung’	1.8	3.0	6.7	-2.2	-1.1	-1.5	-0.0	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	0.4	0.3	-0.1	-0.8
Hair/balding pattern: Pattern 4	1.2	3.0	5.4	-0.9	0.5	-2.3	-2.2	-1.9
Birth weight of first child	2.2	4.0	7.5	-2.4	1.0	-2.2	-2.7	-1.0
Peak expiratory flow (PEF)	0.9	2.1	3.5	-1.9	0.3	-1.6	-1.7	-1.3
Pulse wave reflection index	1.2	1.5	2.9	1.7	0.4	1.4	1.1	1.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.5	-0.8	-0.2	-1.6	-0.8	-0.4
Loud music exposure frequency	1.4	1.5	3.5	1.2	-1.0	1.9	0.9	-0.9
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.4	0.9	-0.9	1.6	1.7	1.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.4	-0.4	-0.4	0.1	-0.0
Blood clot in the leg (DVT)	0.4	0.5	1.6	0.4	1.3	-0.2	-0.5	0.7
Medication: Paracetamol	0.3	0.6	2.1	0.5	1.4	-0.0	-0.7	0.0
Headache pain in last month	0.5	0.8	2.2	0.6	0.8	1.5	1.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.0	-0.5	1.4	0.7	0.5	-0.5
Glaucoma (self-reported)	1.4	1.6	3.3	0.9	-1.4	1.4	1.8	0.2
Gout (self-reported)	1.1	1.6	3.1	-0.7	-0.3	-1.0	-1.8	-1.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.8	0.3	1.0	-0.9	-1.3	-0.6
Medication: Amlodipine	0.8	1.1	2.0	-0.5	-1.3	-1.2	0.2	1.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-0.4	0.7	-1.1	-0.2	-0.5
Birth weight	0.2	0.5	1.7	0.6	1.3	0.2	-0.3	0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	0.3	-0.6	-0.4	1.1	-1.2
High blood pressure (siblings)	0.2	0.3	0.5	-0.3	-0.5	-0.7	0.7	0.2
Forced vital capacity (FVC), Best measure	0.8	2.8	10.0	-0.6	-3.2	0.2	1.8	0.2
Body fat percentage	0.8	3.0	6.2	-0.7	2.3	-1.6	-2.5	-0.2
Leg fat percentage (right)	1.1	4.1	6.0	-2.3	1.4	-2.5	-2.4	-1.2
Arm fat-free mass (right)	0.5	2.3	4.6	-0.1	-2.1	1.6	2.0	-0.8
Exposure to tobacco smoke outside home	1.2	1.6	3.5	0.7	-1.6	0.9	1.9	0.7
Comparative body size at age 10	0.7	2.0	4.6	1.7	0.8	-0.3	-1.3	2.1
Number of full brothers	1.7	2.1	4.0	-2.0	-0.5	-1.8	-0.0	-1.7
Worry too long after embarrassment	3.5	5.9	11.0	3.3	-0.5	3.0	3.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.4	0.7	-0.5	0.2	-0.0
Wheeze or whistling in the chest in last year	0.3	0.5	1.5	-0.4	1.2	-0.7	-0.6	0.0
Number of children fathered	2.6	3.0	5.3	-1.4	1.3	-2.3	-2.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.2	7.2	-0.0	-2.7	-0.6	0.7	-1.7
Age at first live birth	1.2	2.2	4.1	0.9	-1.8	1.6	2.0	-0.4
Pulse wave peak to peak time	0.6	0.7	2.1	-0.7	-0.4	-0.7	0.0	-1.5
Health satisfaction	0.1	0.2	0.3	0.5	0.1	0.5	0.5	0.3
Shortness of breath walking on level ground	0.6	0.7	1.3	1.2	0.0	0.8	0.9	0.9
Qualifications: College or University degree	0.1	0.3	0.9	0.3	-0.5	0.9	0.5	-0.1
Eye problems/disorders: None of the above	0.7	0.8	2.6	1.6	-0.7	0.7	0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.2	-0.2	-0.4	0.4	0.5
Emphysema/chronic bronchitis	0.6	0.7	2.4	1.6	0.2	0.6	0.7	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.9	0.1	0.2	0.9	0.6	0.3
Neck or shoulder pain in last month	0.3	0.4	1.0	0.1	-0.4	0.4	0.7	1.0
Medication: Blood pressure	0.3	0.6	2.0	0.5	-1.4	-0.7	-0.4	0.2
Angina (self-reported)	0.7	0.9	2.2	-0.3	-1.5	-1.1	-0.8	-0.7
Migraine (self-reported)	1.3	1.6	2.9	0.6	0.5	1.7	1.4	1.5
Medication: Ibuprofen	1.0	1.2	2.8	1.7	-0.9	0.5	0.9	1.1
Medication: Allopurinol	0.5	0.7	1.7	0.1	-1.3	-0.3	-1.2	-0.4
Medication: Omeprazole	0.2	0.2	0.7	-0.3	0.4	0.8	0.1	0.5
Medication: Seretide 50 evohaler	1.3	1.5	4.2	2.0	0.1	1.2	0.6	1.1
Mean time to correctly identify matches	2.2	4.2	7.1	1.6	-2.1	2.7	2.7	-0.3
Heart disease (mother)	0.5	0.6	1.0	0.9	-0.9	-0.0	0.5	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	-0.7	-0.7	0.3	0.7	-1.1
Whole body fat mass	0.3	1.4	2.9	-0.6	1.7	-1.0	-1.7	-0.4
Leg fat mass (right)	0.4	1.5	2.3	-1.4	1.1	-1.2	-1.5	-0.9
Arm predicted mass (right)	0.5	2.6	5.6	-0.2	-2.4	1.5	2.1	-0.9
Pulse rate, automated reading	1.9	6.1	8.8	-3.0	2.3	-2.3	-2.9	-1.7
Alcohol intake frequency.	2.9	6.7	14.7	-3.0	1.8	-2.6	-3.8	-0.3
Comparative height size at age 10	0.2	1.1	2.0	-1.3	-1.4	-0.3	-1.0	0.9
Number of full sisters	2.5	3.1	7.2	-2.7	0.0	-2.3	-0.8	-1.5
Suffer from ‘nerves’	2.5	3.9	7.4	-2.1	1.1	-1.9	-1.5	-2.7
Overall health rating	0.6	1.2	2.9	-0.8	1.7	-0.9	-1.1	-0.7
Chest pain or discomfort	0.3	0.4	0.7	0.1	-0.6	-0.7	-0.8	0.8
Had major operations	1.1	1.3	3.3	0.7	1.1	-0.9	-1.8	0.9
Age at last live birth	1.0	1.4	2.2	-1.3	-1.4	-1.1	0.1	-1.5
Family relationship satisfaction	1.4	1.7	4.4	2.1	-0.2	1.2	0.8	1.4
Leg pain on walking	0.2	0.2	0.6	-0.1	0.3	-0.6	0.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.0	0.2	0.8	-0.8	-1.4	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.0	-1.4	0.2	0.0	0.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.3	1.0	1.1	1.0	0.2	-1.1
Medication: Aspirin	0.2	0.2	0.5	0.4	-0.7	-0.4	0.1	-0.5
Supplements: Vitamin C	4.8	5.7	14.2	2.0	-3.8	0.6	3.0	0.8
Knee pain experienced in last month	0.3	0.5	1.9	0.2	-1.4	-0.5	-0.1	0.5
Hypertension (Self-reported)	1.1	3.1	7.3	-1.9	-1.1	-2.7	-1.5	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	-0.8	-0.5	0.2	-0.6	-0.2
Illnesses of father: Heart disease	0.9	1.3	2.3	0.1	1.2	-1.0	-1.5	1.4
Illnesses of siblings: Diabetes	0.3	0.4	1.2	-0.2	-1.1	-0.5	0.6	-0.3
Smoking status: Previous	0.3	0.4	1.2	0.7	-0.3	-1.1	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-0.4	-1.1	0.8	1.3	-0.8
Whole body fat-free mass	0.3	1.7	3.0	0.5	-1.7	1.7	1.6	-0.1
Leg fat-free mass (right)	0.3	1.7	4.3	1.5	-0.4	2.1	1.2	0.7
Arm fat percentage (left)	0.9	3.5	9.7	-0.2	3.1	-1.2	-2.5	-0.1
Average weekly red wine intake	2.7	4.0	11.6	1.6	-3.4	1.5	1.8	-0.0
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.4	0.1	-0.2	-0.1	-0.2
Mood swings	0.7	1.3	2.9	1.7	0.0	1.0	1.4	0.7
Loneliness, isolation	0.4	0.5	1.7	-0.0	-0.4	-1.3	-0.6	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.2	0.8	0.1	0.4	-0.6
Ever had bowel cancer screening	1.2	1.4	3.8	-0.6	-2.0	-1.4	-0.1	0.8
Diabetes diagnosed by doctor	0.2	0.3	0.8	0.4	0.9	0.4	0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	0.2	-1.2	-0.1	0.2	0.4
Friendships satisfaction	0.8	0.9	1.7	1.1	-0.7	1.3	1.0	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.6	0.7	0.0	0.5	-0.0	-0.7
Commuting to job workplace: Walk	0.5	0.5	1.2	0.4	-1.1	-0.5	-0.8	0.3
Eye problems/disorders: Cataract	0.5	0.5	1.6	-1.0	1.2	0.0	-0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	5.3	2.3	-1.2	1.8	1.3	1.4
Medication for cholesterol	1.8	2.7	6.4	1.9	0.7	2.5	0.7	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.1	-0.6	1.3	-1.8	-0.9	-0.3
Back pain experienced in last month	1.0	1.5	5.1	-0.6	-2.3	-0.7	-0.0	1.2
Mineral and other dietary supplements	0.3	0.4	1.6	-1.3	0.3	-0.4	0.1	-0.2
Breast cancer (self-reported)	1.1	1.4	3.3	1.2	0.8	1.1	0.5	1.8
Asthma (self-reported)	0.9	1.8	4.9	1.7	0.2	1.0	0.1	2.2
Osteoporosis (self-reported)	0.2	0.3	0.7	-0.8	0.3	-0.3	0.2	0.8
Osteoarthritis (self-reported)	3.6	4.7	6.2	-2.0	2.2	-2.0	-2.5	-2.1
Medication: Aspirin	0.3	0.3	0.9	-0.1	-0.6	-0.9	-0.4	-0.5
Medication: Gliclazide	0.7	0.7	1.7	1.1	1.3	0.8	0.1	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.6	0.5	1.1	0.6	0.5
Smoking status: Current	0.6	0.9	3.0	-1.7	0.6	0.3	0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.0	-0.7	-1.4	-0.9	0.8	-0.3
Whole body water mass	0.3	1.8	3.2	0.4	-1.8	1.7	1.6	-0.2
Leg predicted mass (right)	0.3	1.7	4.3	1.5	-0.4	2.1	1.1	0.6
Arm fat mass (left)	0.3	1.4	3.2	-0.5	1.8	-0.8	-1.6	-0.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	0.5	-0.4	0.3	0.3	1.0
Average weekly champagne plus white wine intake	3.8	5.2	7.9	2.0	-1.6	2.1	2.6	2.8
Miserableness	0.4	0.7	2.3	0.7	0.7	0.2	-0.3	1.5
Guilty feelings	0.6	0.9	1.6	1.1	-1.0	0.7	1.3	0.4
Wears glasses or contact lenses	0.2	0.2	0.4	0.2	-0.6	0.3	-0.4	0.6
Ever taken oral contraceptive pill	0.8	0.9	4.0	2.0	0.6	0.3	-0.0	-0.4
Hearing aid user	0.6	0.7	2.0	-0.1	0.8	-0.7	-0.4	-1.4
Mother’s age at death	0.2	0.2	0.8	0.3	-0.1	0.5	-0.2	-0.9
Financial situation satisfaction	0.4	0.6	1.2	-0.6	1.1	-0.4	-1.0	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.3	-0.5	0.0	0.5	0.2
Commuting to job workplace: Public transport	0.7	0.8	3.4	1.8	0.4	0.6	0.2	0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	0.6	-0.8	0.8	1.0	-0.4
Medication: Blood pressure	3.6	6.9	17.1	-3.1	0.0	-4.1	-2.4	-1.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.8	-0.4	-0.5	0.1	0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.4	1.9	-0.6	0.5	0.6	0.9
High cholesterol (Self-reported)	0.2	0.3	0.6	0.6	-0.7	-0.1	0.8	-0.2
Medication: Bendroflumethiazide	2.2	3.4	6.8	-1.2	2.3	-2.6	-1.5	-1.1
Medication: Paracetamol	0.5	0.8	2.9	0.1	1.7	-0.3	-0.9	0.1
Medication: Lisinopril	0.8	1.0	1.8	1.4	-0.1	1.3	1.2	0.1
Medication: Atorvastatin	0.8	0.9	2.3	1.0	-1.0	0.4	0.6	1.5
Illnesses of father: High blood pressure	1.1	1.4	3.0	-1.3	-0.4	-1.7	-0.9	-1.1
Alcohol drinker status: Never	0.8	1.0	3.1	-1.0	0.2	-0.9	-1.8	-0.0
Ever smoked	0.3	0.5	1.0	-0.3	-0.8	-0.7	1.0	-0.7
Basal metabolic rate	0.1	0.8	1.5	0.2	-1.1	1.2	1.1	-0.2
Leg fat percentage (left)	0.6	2.3	3.2	-1.6	1.5	-1.6	-1.8	-1.0
Arm fat-free mass (left)	0.3	1.5	3.5	-0.6	-1.9	0.9	1.4	-0.9
Number of operations (self-reported)	0.7	1.1	2.2	0.2	-0.1	-1.4	-1.1	1.5
Average weekly beer plus cider intake	1.4	2.0	3.7	0.1	-1.9	1.6	1.9	-0.7
Irritability	0.5	0.8	1.9	1.2	0.1	1.4	0.9	-0.2
Risk taking	1.3	2.0	5.1	0.5	-2.3	0.1	1.3	1.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	0.7	0.1	0.1	0.1	-0.1
Fractured/broken bones in last 5 years	2.1	2.7	9.7	0.4	-1.4	0.3	-1.2	3.1
Age started oral contraceptive pill	0.7	0.8	2.5	0.3	-1.6	1.0	0.2	0.7
Diastolic blood pressure, automated reading	1.1	3.5	5.5	-2.3	1.6	-2.2	-1.1	-1.9
Ever depressed for a whole week	0.7	0.8	1.8	0.1	-1.4	0.7	1.3	0.5
Unable to work because of sickness or disability	1.5	1.9	3.9	-1.3	2.0	-1.4	-1.3	-0.4
Commuting to job workplace: Cycle	6.7	8.1	14.3	3.8	-2.0	3.1	2.6	2.4
Myopia	0.9	1.3	2.3	1.4	-0.6	1.3	1.5	0.3
Vascular/heart problems diagnosed by doctor	1.0	2.6	6.2	1.4	1.6	2.5	1.3	0.6
Cholesterol lowering medication	1.0	1.4	3.3	1.1	-1.5	0.5	1.8	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.9	0.6	0.3	-0.3	0.6
Pain experienced in last month	0.4	0.6	1.4	-0.5	0.9	-0.4	-0.7	-1.2
Supplements: Calcium	0.4	0.4	1.6	1.3	0.3	-0.0	0.4	-0.6
Basal cell carcinoma (self-reported)	0.7	0.8	2.0	-0.8	-0.2	-1.4	-0.5	-1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.2	-0.7	0.3	-1.5	-1.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	0.4	1.3	-0.2	-0.4	0.5
Heart disease (siblings)	0.2	0.3	0.9	-0.4	-0.7	-0.9	0.0	-0.0
Alcohol drinker status: Previous	1.4	1.6	4.9	0.3	-1.5	0.4	0.8	2.2
Pack years of smoking	0.8	1.2	3.4	-1.9	0.4	-0.9	-0.6	-1.1
Impedance of whole body	0.5	2.8	6.8	-0.9	0.9	-2.0	-2.6	1.1
Leg fat mass (left)	0.3	1.0	1.4	-1.1	1.1	-0.8	-1.2	-0.8
Arm predicted mass (left)	0.3	1.6	3.6	-0.5	-1.9	1.0	1.4	-0.9