Best TWAS P=6.21e-38 · Best GWAS P=8.77e-275 conditioned to 1.02e-148
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ME3 | 0.18 | 0.00 | lasso | 9 | 0.02 | 1.1e-02 | -16.5 | 10.4 | 3.7e-25 | -0.32 | 0.11 | 0.03 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | FZD4 | 0.07 | 0.07 | lasso | 2 | 0.05 | 2.1e-04 | 10.4 | -10.6 | 4.9e-26 | 0.45 | 0.78 | 0.01 | TRUE |
| 3 | GTEx | Spleen | TMEM135 | 0.25 | 0.04 | lasso | 8 | 0.04 | 2.9e-02 | -2.2 | -8.9 | 4.5e-19 | 0.16 | 0.13 | 0.07 | TRUE |
| 4 | METSIM | Adipose | ME3 | 0.13 | 0.01 | bslmm | 677 | 0.04 | 2.9e-07 | -1.1 | 12.9 | 8.2e-38 | -0.33 | 0.22 | 0.13 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM135 | 0.06 | 0.00 | blup | 212 | 0.03 | 2.8e-04 | -12.4 | -12.9 | 6.2e-38 | 0.29 | 0.06 | 0.10 | TRUE |