Hub : Genes

TMEM135

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.060 0.028 0.0110 0.017 0.007 0.010 0.014 0.009 0.0031 0.03700 0.02100 0.0069 0.022
2 GTEx Spleen 0.249 0.091 0.0055 0.037 NA 0.039 NA 0.043 0.0410 NA 0.03700 NA 0.029
3 TCGA Thyroid Carcinoma 0.063 0.030 0.0019 0.003 0.034 0.029 NA 0.013 0.1600 0.00028 0.00079 NA 0.016

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.9 1.4 3.5 -0.2 0.9 -1.9
Bipolar Disorder or Schizophrenia 0.6 1.4 2.8 -0.5 1.1 -1.7
Depressed Affect (Nagel 2018) 0.5 1.1 1.5 -1.0 0.9 1.2
Depression (Nagel 2018) 0.1 0.2 0.5 -0.3 0.7 0.3
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 -0.4 0.3 -0.6
Neuroticism (Nagel 2018) 1.0 2.3 3.3 -1.3 1.8 1.3
Schizophrenia (2018) 0.2 0.4 0.5 -0.5 0.7 -0.7
Schizophrenia vs Biploar Disorder 0.9 1.2 1.4 -1.1 -1.0 1.2
Worry (Nagel 2018) 1.5 3.3 4.1 -1.6 2.0 1.8
Alzheimer’s Disease (in mother) 1.4 1.6 2.8 0.8 1.7 1.2
Alzheimer’s Disease (in father) 1.5 1.6 4.1 0.4 -2.0 -0.9
Alzheimer’s Disease (including proxy) 0.5 0.8 2.0 1.4 -0.5 -0.3
Crohns Disease (2017) 1.9 4.1 10.0 1.4 -3.2 -0.6
Irritable Bowel Disease (IBD) 1.8 4.4 7.7 2.1 -2.8 -1.0
Ulcerative Colitis (UC) 1.9 3.5 5.7 2.4 -1.9 -1.0
Major Depression (MDD) 0.2 0.2 0.4 -0.0 0.4 0.6
Reaction Time 0.4 0.8 2.0 -0.0 0.7 1.4
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.2 0.4 0.2
Breast Cancer 0.3 0.8 2.1 -1.4 0.4 0.4
Ovarian Cancer 0.4 0.6 1.0 -1.0 0.9 0.1
Prostate Cancer 1.3 1.8 5.2 0.4 -2.3 0.1
Age at First Birth 0.5 0.8 1.7 -0.7 1.3 -0.2
Bipolar Disorder (2011) 2.5 2.4 7.0 -2.6 -0.5 -0.2
Body Mass Index (BMI) (2010) 0.2 0.3 0.8 -0.1 -0.2 -0.9
Coronary Artery Disease (CAD) 0.5 0.6 1.7 -1.3 -0.1 0.3
Crohns Disease (2012) 1.1 1.8 3.0 1.6 -1.7 -0.2
Mean Putamen Volume 0.3 0.4 0.4 -0.6 -0.7 0.5
Fasting Glucose 0.4 0.5 0.8 -0.9 -0.6 0.5
HbA1C 0.4 0.4 0.4 -0.6 -0.6 0.6
HDL Cholesterol 0.9 1.6 1.9 -1.4 1.3 -1.0
LDL Cholesterol 0.5 0.8 2.0 0.5 -1.4 -0.2
Lupus 1.6 2.4 3.2 -0.9 -1.7 -1.8
Neuroticism (2016) 0.3 0.5 1.3 0.3 0.3 -1.1
Primary Biliary Cirrhosis 2.6 3.6 9.9 0.7 -0.7 -3.2
Rheumatoid Arthritis 0.6 0.8 0.8 0.9 -0.9 -0.9
Schizophrenia (2014) 0.4 0.9 1.9 -1.4 0.6 -0.6
Triglycerides 1.1 1.8 3.5 1.9 -1.1 -0.7
Type 2 Diabetes (T2D) (2012) 2.4 2.7 4.1 0.8 -1.9 -2.0
Ulcerative Colitis 0.9 1.4 3.6 1.9 -0.7 -0.1
Blood Eosinophil Count 0.1 0.9 2.5 1.6 -0.3 0.0
Blood Platelet Count 0.4 4.7 10.2 0.5 1.9 3.2
Blood Red Count 0.0 0.2 0.4 -0.7 -0.2 0.4
Blood White Count 0.2 1.2 3.5 1.9 -0.3 -0.1
Heel T-Score 10.3 82.3 166.4 -1.0 -8.9 -12.9
BMI 0.2 1.3 3.4 0.1 1.8 0.7
Height 0.2 3.6 6.1 2.5 -1.8 -1.2
Waist Hip Ratio (WHR) 0.1 0.5 0.8 0.8 0.1 -0.9
Systolic Blood Pressure 0.0 0.1 0.2 0.4 0.2 0.3
Smoking Status 1.0 2.3 5.3 2.3 0.7 -1.1
Allergy or Eczema 1.6 4.3 7.6 2.8 -2.3 -0.3
Cardiovascular Disease 0.0 0.1 0.2 0.4 0.1 0.2
Hypothyroidism (self reported) 0.3 0.8 1.7 0.7 0.2 1.3
Respiratory disease 0.7 1.6 4.6 0.3 0.1 -2.1
Type 2 Diabetes (T2D) (2018) 2.1 4.0 6.9 2.6 0.2 -2.2
Lung FEV1/FVC ratio 0.1 0.6 1.3 0.2 0.8 1.1
Lung FVC 0.1 0.7 1.5 -0.5 -1.2 0.5
Neuroticism 1.1 2.7 3.2 -1.7 1.4 1.8
Chronotype (morning person) 1.4 3.3 8.5 -2.9 1.0 0.6
Hair Pigment 0.0 1.3 1.8 -1.3 1.3 0.6
Tanning 0.2 2.1 5.0 1.1 -0.2 2.2
Hand grip strength (left) 0.6 1.5 3.2 -0.7 -0.8 -1.8
Number of treatments/medications taken 0.9 1.7 4.1 2.0 -0.7 -0.7
Average weekly spirits intake 1.8 2.2 4.9 2.2 0.1 -1.3
Sensitivity / hurt feelings 0.1 0.2 0.2 0.5 -0.4 -0.4
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.2 1.1 1.0 0.7
Hearing difficulty/problems: Yes 1.3 2.0 5.0 -1.0 2.2 0.3
Relative age of first facial hair 0.5 1.0 2.3 -1.5 0.4 0.8
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.9 1.7 0.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.9 1.1 1.6 0.9 -1.3 -1.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.8 0.2 -0.5 -0.9
Systolic blood pressure, automated reading 0.0 0.0 0.1 -0.3 -0.0 -0.2
Eye problems/disorders: Diabetes related eye disease 4.6 5.1 10.3 3.2 -2.2 -0.2
Angina 1.0 1.3 2.3 1.3 -1.5 0.1
Medication for hormone replacement therapy 0.2 0.2 0.5 0.0 -0.4 -0.7
Vitamin and mineral supplements 0.6 0.8 1.8 -1.3 -0.7 -0.2
Supplements: Zinc 0.6 0.7 1.4 0.4 0.7 -1.2
Medication: Co-codamol 0.6 0.7 1.6 1.3 0.6 -0.4
Medication: Metformin 1.3 1.8 3.3 1.8 0.7 -1.3
Diabetes (father) 1.2 1.5 2.3 1.0 1.1 -1.5
Diabetes (mother) 1.2 1.5 3.4 -0.1 -1.1 -1.8
Severe depression (siblings) 1.9 2.1 3.2 1.8 1.8 0.4
Pack years adult smoking proportion 0.6 1.0 2.4 -0.7 0.1 1.6
Impedance of leg (right) 1.4 6.9 13.5 2.3 -3.7 -1.5
Leg fat-free mass (left) 0.3 1.7 4.0 -0.9 2.0 -0.6
Trunk fat percentage 0.3 1.0 2.9 1.7 -0.2 -0.4
Hand grip strength (right) 0.3 0.9 1.4 -1.2 -0.7 -0.9
Townsend deprivation index at recruitment 1.6 2.3 3.6 0.7 1.9 1.7
Current tobacco smoking 0.8 1.3 2.5 1.6 0.1 -1.2
Average weekly fortified wine intake 0.9 1.0 1.8 1.3 1.1 0.3
Maternal smoking around birth 0.5 0.7 1.6 -0.1 -0.8 -1.3
Fed-up feelings 0.3 0.6 1.1 -0.3 1.1 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 0.5 0.9 0.5
Relative age voice broke 0.7 1.1 2.5 -1.6 0.9 0.0
Taking other prescription medications 0.2 0.4 0.5 0.7 0.4 -0.7
Age when periods started (menarche) 0.5 1.1 2.9 -1.7 0.5 -0.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.3 3.5 -0.7 -0.0 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 6.8 15.4 25.3 -0.4 -4.5 -5.0
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.4 -1.2 0.3 1.0
Qualifications: CSEs or equivalent 1.3 1.7 4.0 0.7 -0.7 -2.0
Serious illness, injury or assault to yourself 1.2 1.4 3.2 -1.8 1.0 -0.2
High blood pressure 0.4 1.2 2.9 1.7 0.5 0.6
Hayfever, allergic rhinitis or eczema 1.3 2.9 4.6 2.1 -1.7 -1.1
Multivitamins +/- minerals 0.5 0.6 1.9 1.4 0.1 -0.0
Stomach or abdominal pain in last month 0.4 0.5 0.7 0.8 -0.7 -0.5
Supplements: Glucosamine 0.4 0.5 0.8 -0.9 0.8 -0.4
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.7 0.1 -0.6 -1.6
Medication: Atenolol 2.2 2.7 4.3 0.7 -2.1 -1.8
Medication: Levothyroxine sodium 0.1 0.2 0.3 0.5 0.6 -0.2
Sitting height 0.7 4.9 7.3 2.7 -1.8 -2.0
Chronic bronchitis/emphysema (father) 1.6 1.9 3.3 1.8 0.0 -1.5
High blood pressure (mother) 1.8 2.5 6.3 1.1 -0.2 -2.5
Body mass index (BMI) 0.3 1.1 3.4 -0.1 1.8 -0.0
Impedance of leg (left) 1.3 6.2 12.9 2.2 -3.6 -1.0
Leg predicted mass (left) 0.3 1.8 3.9 -1.0 2.0 -0.7
Trunk fat mass 0.2 0.7 1.6 1.3 0.4 -0.6
Waist circumference 0.3 1.2 2.3 1.1 1.5 0.0
Number of incorrect matches in round 0.3 0.6 0.8 0.8 0.9 0.5
Past tobacco smoking 2.2 4.1 11.6 -3.4 -0.8 0.3
Alcohol usually taken with meals 0.3 0.6 1.2 -0.2 0.6 1.1
Nervous feelings 0.3 0.5 0.9 0.7 0.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.0 1.0 0.7 -0.5
Hearing difficulty/problems with background noise 0.1 0.2 0.3 0.3 0.6 0.3
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 -1.0 -0.1 0.5
Had menopause 0.7 0.9 2.4 1.5 -0.3 0.5
Had other major operations 2.8 3.4 9.2 0.9 -0.4 -3.0
Forced vital capacity (FVC) 0.1 0.3 0.7 -0.4 -0.8 0.2
Heel bone mineral density (BMD) T-score, automated (right) 5.7 13.2 22.8 -0.1 -4.1 -4.8
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 1.6 1.1 0.0 1.3
Qualifications: None of the above 0.5 1.2 1.8 1.3 -0.3 1.3
Financial difficulties in last 2 years 0.3 0.4 0.7 0.5 0.3 0.9
Mouth/teeth dental problems 0.3 0.5 1.1 0.5 -1.1 0.2
Heart attack 1.5 1.9 2.8 -0.6 1.6 1.7
Allergy 1.8 4.2 5.6 -2.4 1.5 2.2
Pain all over the body in last month 1.5 1.6 2.7 -1.6 0.4 1.4
Diabetes (self-reported) 1.5 2.3 5.8 2.4 0.2 -1.0
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 6.9 0.2 -2.6 -1.2
Medication: Ramipril 0.7 0.9 1.7 1.3 -0.5 0.8
Medication: Simvastatin 0.9 1.3 3.4 1.8 -0.6 -0.3
Fluid intelligence score 0.2 0.5 1.1 -0.7 -0.1 -1.0
Illnesses of siblings 0.6 0.8 1.3 -1.2 -0.9 0.4
Neuroticism score 0.5 1.0 1.5 -0.9 1.2 0.9
Weight 0.2 0.9 2.3 0.2 1.5 -0.6
Impedance of arm (right) 0.8 3.6 6.5 2.1 -2.5 -0.0
Arm fat percentage (right) 0.1 0.6 1.0 0.8 1.0 0.1
Trunk fat-free mass 0.4 2.1 4.4 -1.0 2.1 -0.9
Hip circumference 0.1 0.5 1.1 0.7 1.0 0.0
Time employed in main current job 0.3 0.4 0.7 0.8 -0.5 0.4
Alcohol intake versus 10 years previously 3.2 4.7 7.8 -2.1 -2.8 -1.4
Father’s age at death 0.3 0.4 1.0 0.5 0.2 -1.0
Worrier / anxious feelings 1.2 2.2 3.0 -1.7 1.6 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 1.8 1.3 1.2 -0.6
Falls in the last year 2.2 3.0 6.8 -2.6 1.2 0.9
Hair/balding pattern: Pattern 3 0.3 0.5 0.5 0.6 0.7 0.7
Number of live births 0.3 0.4 0.8 0.4 0.9 0.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.8 -0.9 -0.5 0.5
Pulse rate 0.1 0.2 0.4 -0.6 -0.2 0.5
Happiness 2.4 2.9 6.7 -0.6 2.6 1.3
Noisy workplace 0.8 0.9 2.5 0.4 1.6 -0.4
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.2 -0.4 1.5 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.1 -1.0 0.7 -0.2
Mouth/teeth dental problems: Dentures 0.2 0.3 0.5 -0.5 0.7 -0.3
Asthma 0.9 1.9 4.8 0.8 -0.3 -2.2
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 5.9 -0.3 0.2 -2.4
Medication: Cholesterol lowering 0.8 1.2 2.5 1.6 -0.8 0.6
Depression (self-reported) 0.1 0.1 0.2 -0.3 0.4 0.4
Medication: Lansoprazole 1.0 1.1 3.2 0.0 -0.4 -1.8
Prospective memory result 0.2 0.2 0.3 0.6 0.4 -0.3
Lung cancer (father) 0.8 0.9 2.2 0.8 -0.3 -1.5
Illnesses of mother 0.9 1.2 1.8 -0.4 -1.3 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.5 1.1 -1.1 -0.4 0.4
Pulse wave Arterial Stiffness index 2.5 2.9 4.5 2.1 0.2 -2.1
Impedance of arm (left) 0.6 2.9 5.3 1.8 -2.3 0.0
Arm fat mass (right) 0.2 0.6 1.7 0.4 1.3 -0.3
Trunk predicted mass 0.4 2.1 4.4 -1.1 2.1 -0.9
Standing height 0.1 1.0 2.1 0.7 -0.6 -1.4
Length of working week for main job 1.4 1.5 3.8 -1.9 0.9 0.1
Exposure to tobacco smoke at home 1.0 1.1 2.0 -0.0 1.4 1.1
Breastfed as a baby 1.7 2.1 4.6 -0.2 1.2 2.1
Tense / ‘highly strung’ 0.4 0.6 0.8 0.8 0.9 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.2 1.8 0.1 -0.1
Hair/balding pattern: Pattern 4 0.3 0.8 1.3 -1.1 1.1 -0.1
Birth weight of first child 0.2 0.3 0.6 -0.0 0.5 0.8
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.4 -0.1 -0.7
Pulse wave reflection index 0.4 0.5 1.0 0.6 0.6 -1.0
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.1 -1.4 1.0 0.6
Loud music exposure frequency 0.2 0.2 0.3 -0.0 -0.5 -0.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.3 -0.3 1.5 -0.9
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 0.3 0.7 0.8
Blood clot in the leg (DVT) 0.4 0.6 1.1 1.0 0.5 -0.7
Medication: Paracetamol 1.0 1.6 1.9 1.2 -1.3 -1.4
Headache pain in last month 3.0 5.1 7.6 2.8 -2.4 -1.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 2.7 -1.1 0.3 -1.7
Glaucoma (self-reported) 0.7 0.8 1.8 1.3 -0.6 -0.4
Gout (self-reported) 0.0 0.1 0.1 0.2 -0.3 -0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 0.7 0.5 0.8
Medication: Amlodipine 0.4 0.5 1.0 0.7 0.0 -1.0
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.6 -0.4 1.6 -0.2
Birth weight 0.1 0.2 0.6 -0.3 0.2 0.8
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.6 -1.3 0.2 0.8
High blood pressure (siblings) 0.1 0.2 0.3 0.5 0.3 -0.3
Forced vital capacity (FVC), Best measure 0.1 0.3 0.6 -0.8 -0.4 0.3
Body fat percentage 0.2 0.9 2.5 1.6 0.2 -0.4
Leg fat percentage (right) 0.2 0.8 1.8 1.3 0.1 -0.8
Arm fat-free mass (right) 0.4 2.0 3.4 -1.2 1.8 -1.1
Exposure to tobacco smoke outside home 0.4 0.6 0.9 -0.9 0.9 -0.1
Comparative body size at age 10 1.1 3.0 5.6 -0.2 2.4 1.9
Number of full brothers 0.4 0.5 1.0 -0.3 1.0 0.6
Worry too long after embarrassment 0.1 0.2 0.6 0.8 0.1 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.8 1.4 -0.7 0.7
Wheeze or whistling in the chest in last year 1.2 2.1 4.9 1.1 -0.5 -2.2
Number of children fathered 0.9 1.1 1.7 0.1 1.3 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 2.3 1.0 -1.5 -1.3
Age at first live birth 0.2 0.3 0.5 -0.6 0.7 0.0
Pulse wave peak to peak time 2.2 2.6 4.1 -2.0 -0.2 2.0
Health satisfaction 1.3 1.7 2.2 1.4 1.5 -0.8
Shortness of breath walking on level ground 0.8 0.9 1.3 -0.5 1.1 1.1
Qualifications: College or University degree 1.4 4.5 11.0 -0.9 3.3 1.3
Eye problems/disorders: None of the above 0.2 0.2 0.3 0.5 0.4 0.3
Mouth/teeth dental problems: Loose teeth 1.6 1.9 2.9 0.7 1.7 1.5
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.2 -0.5 0.2
Medication for pain relief, constipation, heartburn 2.6 4.5 7.8 -1.1 2.1 2.8
Neck or shoulder pain in last month 0.6 0.9 1.8 0.9 -0.3 -1.3
Medication: Blood pressure 0.8 1.5 3.5 0.7 0.7 1.9
Angina (self-reported) 0.9 1.2 2.0 1.2 -1.4 -0.0
Migraine (self-reported) 0.3 0.4 0.6 -0.8 -0.1 0.7
Medication: Ibuprofen 0.3 0.4 0.9 -0.1 0.5 -1.0
Medication: Allopurinol 1.0 1.4 3.1 0.9 0.4 -1.8
Medication: Omeprazole 0.3 0.3 0.9 -0.2 -0.9 -0.2
Medication: Seretide 50 evohaler 0.5 0.6 1.0 0.4 1.0 -0.7
Mean time to correctly identify matches 0.7 1.4 3.4 0.9 -0.1 1.8
Heart disease (mother) 0.9 1.0 2.3 0.1 1.5 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.8 0.1 1.3 0.5
Whole body fat mass 0.1 0.6 0.9 0.9 0.9 -0.3
Leg fat mass (right) 0.2 0.6 0.9 0.5 0.9 -0.9
Arm predicted mass (right) 0.4 1.8 2.7 -1.0 1.6 -1.4
Pulse rate, automated reading 0.3 1.1 1.8 1.4 -1.1 0.4
Alcohol intake frequency. 0.8 1.8 2.5 -1.2 -1.6 1.3
Comparative height size at age 10 0.0 0.2 0.6 0.3 -0.2 -0.7
Number of full sisters 0.3 0.4 1.2 -0.3 -0.1 1.1
Suffer from ‘nerves’ 1.2 1.9 4.9 -0.7 2.2 0.5
Overall health rating 0.6 1.3 3.0 0.6 1.7 0.7
Chest pain or discomfort 0.2 0.3 0.9 0.4 0.1 -0.9
Had major operations 0.3 0.4 1.1 0.1 1.1 -0.2
Age at last live birth 0.9 1.4 2.0 -1.1 1.4 0.9
Family relationship satisfaction 0.3 0.4 1.0 -0.4 -0.1 1.0
Leg pain on walking 0.9 1.1 1.7 -1.3 1.2 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.4 -0.3 -0.5 -1.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.0 -0.4 -0.5 -1.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.8 0.9 -0.0 0.9
Medication: Aspirin 1.8 2.4 5.3 0.4 -2.3 -1.3
Supplements: Vitamin C 0.4 0.5 0.5 0.7 0.7 0.7
Knee pain experienced in last month 1.0 1.6 2.7 1.3 -0.6 -1.6
Hypertension (Self-reported) 0.3 0.9 1.5 1.2 0.7 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.0 -0.8 1.0 -0.3
Illnesses of father: Heart disease 0.3 0.4 0.8 -0.1 0.7 0.9
Illnesses of siblings: Diabetes 1.7 2.1 3.6 1.9 1.1 -1.1
Smoking status: Previous 1.3 1.9 4.8 2.2 0.9 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 0.3 -0.3 0.4
Whole body fat-free mass 0.4 2.1 4.6 -1.0 2.1 -0.8
Leg fat-free mass (right) 0.4 2.1 4.8 -1.1 2.2 -0.4
Arm fat percentage (left) 0.1 0.6 1.4 0.6 1.2 -0.0
Average weekly red wine intake 1.7 2.5 5.8 2.4 0.4 -1.2
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.5 -0.7 0.5 -0.5
Mood swings 0.3 0.5 1.0 -0.6 1.0 0.0
Loneliness, isolation 0.5 0.7 1.9 -0.1 0.4 1.4
Long-standing illness, disability or infirmity 0.5 0.8 1.1 1.0 -0.6 -1.1
Ever had bowel cancer screening 0.3 0.3 0.6 0.3 0.6 -0.8
Diabetes diagnosed by doctor 1.2 1.9 5.0 2.2 -0.0 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.3 -0.6 0.2 -2.1
Friendships satisfaction 1.1 1.3 3.2 0.3 1.8 0.9
Qualifications: nursing, teaching 1.0 1.6 2.4 -1.5 1.6 -0.1
Commuting to job workplace: Walk 0.5 0.5 0.9 0.1 0.8 1.0
Eye problems/disorders: Cataract 1.5 1.7 4.4 -0.7 2.1 0.6
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 0.2 -0.4 -0.6
Medication for cholesterol 1.0 1.6 2.2 -1.2 1.0 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.3 -1.1 -0.5 -0.6
Back pain experienced in last month 3.1 4.5 5.9 2.2 -2.4 -1.6
Mineral and other dietary supplements 0.7 0.9 1.7 1.3 -0.3 -1.0
Breast cancer (self-reported) 0.3 0.3 1.0 0.2 0.2 1.0
Asthma (self-reported) 1.2 2.4 6.0 1.0 -0.4 -2.5
Osteoporosis (self-reported) 0.1 0.1 0.1 0.2 0.3 -0.2
Osteoarthritis (self-reported) 0.7 0.9 2.2 -0.4 -0.6 -1.5
Medication: Aspirin 1.3 1.7 3.2 0.7 -1.8 -1.2
Medication: Gliclazide 2.3 2.6 3.8 1.9 -1.3 -1.5
Illnesses of father: None of the above (group 1) 0.5 0.6 1.0 -0.8 0.4 -1.0
Smoking status: Current 1.0 1.6 3.1 1.8 0.2 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 3.6 -1.9 1.2 1.8
Whole body water mass 0.4 2.2 4.8 -1.1 2.2 -0.7
Leg predicted mass (right) 0.4 2.0 4.6 -1.1 2.1 -0.3
Arm fat mass (left) 0.2 0.8 2.1 0.4 1.4 -0.1
Number of self-reported non-cancer illnesses 1.1 1.9 5.5 0.4 -0.4 -2.3
Average weekly champagne plus white wine intake 0.5 0.6 1.4 0.4 -0.6 1.2
Miserableness 0.3 0.5 0.7 -0.8 0.8 0.3
Guilty feelings 1.0 1.5 2.9 0.1 1.7 1.3
Wears glasses or contact lenses 1.4 1.6 2.7 1.1 -1.7 -0.9
Ever taken oral contraceptive pill 0.3 0.3 0.8 0.2 0.9 0.4
Hearing aid user 0.6 0.7 0.8 0.8 -0.9 -0.8
Mother’s age at death 0.5 0.6 1.5 -0.1 -0.6 -1.2
Financial situation satisfaction 0.8 1.0 2.1 0.3 0.9 1.4
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.5 0.7 0.0 0.1
Commuting to job workplace: Public transport 0.3 0.4 0.5 -0.6 -0.4 0.7
Eye problems/disorders: Glaucoma 1.1 1.3 1.7 1.2 -1.3 -0.8
Medication: Blood pressure 0.4 0.7 1.7 1.3 -0.4 -0.5
Pain type(s) experienced in last month: Hip pain 2.3 2.9 7.2 -0.6 1.1 -2.7
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.5 -0.9 -1.2 -0.0
High cholesterol (Self-reported) 0.6 1.0 1.4 0.9 -0.9 -1.2
Medication: Bendroflumethiazide 0.6 1.0 2.9 1.7 -0.0 0.0
Medication: Paracetamol 0.8 1.3 2.3 1.1 -0.5 -1.5
Medication: Lisinopril 0.0 0.0 0.1 -0.3 -0.1 0.2
Medication: Atorvastatin 0.2 0.2 0.6 -0.1 -0.8 -0.1
Illnesses of father: High blood pressure 0.5 0.7 0.8 0.9 -0.8 -0.8
Alcohol drinker status: Never 0.1 0.1 0.1 -0.4 -0.4 0.3
Ever smoked 2.2 3.8 9.5 3.1 1.4 -0.1
Basal metabolic rate 0.3 1.7 4.0 -0.7 2.0 -0.8
Leg fat percentage (left) 0.2 0.6 1.7 1.3 0.3 -0.3
Arm fat-free mass (left) 0.2 1.2 2.6 -0.7 1.6 -0.8
Number of operations (self-reported) 0.6 0.9 2.6 0.1 0.0 -1.6
Average weekly beer plus cider intake 0.5 0.7 0.9 0.9 -1.0 -0.6
Irritability 0.8 1.4 3.1 -0.8 1.8 0.8
Risk taking 1.4 2.1 5.4 2.3 -0.6 0.7
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 0.6 0.2 -1.2
Fractured/broken bones in last 5 years 3.4 4.3 9.0 0.4 2.0 3.0
Age started oral contraceptive pill 0.3 0.3 0.7 0.5 -0.2 0.9
Diastolic blood pressure, automated reading 0.3 1.1 1.5 -1.0 1.2 0.9
Ever depressed for a whole week 0.3 0.4 0.8 0.9 -0.5 -0.1
Unable to work because of sickness or disability 0.3 0.4 0.7 0.8 0.5 0.6
Commuting to job workplace: Cycle 0.5 0.6 1.4 -0.5 -0.2 -1.2
Myopia 0.6 0.8 1.3 0.6 1.1 0.9
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.3 -1.8 -0.2 -1.3
Cholesterol lowering medication 0.7 1.1 1.7 1.0 -0.7 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 0.2 -0.7 -0.6
Pain experienced in last month 1.6 2.7 4.6 -0.1 1.9 2.1
Supplements: Calcium 1.3 1.4 2.5 -0.9 0.9 1.6
Basal cell carcinoma (self-reported) 0.2 0.2 0.5 0.4 -0.7 0.1
Heart attack/myocardial infarction (self-reported) 1.3 1.6 2.7 -0.4 1.4 1.6
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.3 1.5 0.2 -0.3
Heart disease (siblings) 0.3 0.4 1.0 -0.1 1.0 0.4
Alcohol drinker status: Previous 1.8 2.1 2.9 1.1 -1.7 1.4
Pack years of smoking 0.4 0.6 1.7 -0.4 0.1 1.3
Impedance of whole body 1.3 6.6 13.0 2.5 -3.6 -0.6
Leg fat mass (left) 0.1 0.6 1.1 0.4 1.1 -0.6
Arm predicted mass (left) 0.2 0.9 1.8 -0.5 1.3 -0.7