Hub : Genes

TMEM135

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.060	0.028	0.0110	0.017	0.007	0.010	0.014	0.009	0.0031	0.03700	0.02100	0.0069	0.022
2	GTEx	Spleen	0.249	0.091	0.0055	0.037	NA	0.039	NA	0.043	0.0410	NA	0.03700	NA	0.029
3	TCGA	Thyroid Carcinoma	0.063	0.030	0.0019	0.003	0.034	0.029	NA	0.013	0.1600	0.00028	0.00079	NA	0.016

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.4	3.5	-0.2	0.9	-1.9
Bipolar Disorder or Schizophrenia	0.6	1.4	2.8	-0.5	1.1	-1.7
Depressed Affect (Nagel 2018)	0.5	1.1	1.5	-1.0	0.9	1.2
Depression (Nagel 2018)	0.1	0.2	0.5	-0.3	0.7	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.4	0.3	-0.6
Neuroticism (Nagel 2018)	1.0	2.3	3.3	-1.3	1.8	1.3
Schizophrenia (2018)	0.2	0.4	0.5	-0.5	0.7	-0.7
Schizophrenia vs Biploar Disorder	0.9	1.2	1.4	-1.1	-1.0	1.2
Worry (Nagel 2018)	1.5	3.3	4.1	-1.6	2.0	1.8
Alzheimer’s Disease (in mother)	1.4	1.6	2.8	0.8	1.7	1.2
Alzheimer’s Disease (in father)	1.5	1.6	4.1	0.4	-2.0	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.0	1.4	-0.5	-0.3
Crohns Disease (2017)	1.9	4.1	10.0	1.4	-3.2	-0.6
Irritable Bowel Disease (IBD)	1.8	4.4	7.7	2.1	-2.8	-1.0
Ulcerative Colitis (UC)	1.9	3.5	5.7	2.4	-1.9	-1.0
Major Depression (MDD)	0.2	0.2	0.4	-0.0	0.4	0.6
Reaction Time	0.4	0.8	2.0	-0.0	0.7	1.4
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.2	0.4	0.2
Breast Cancer	0.3	0.8	2.1	-1.4	0.4	0.4
Ovarian Cancer	0.4	0.6	1.0	-1.0	0.9	0.1
Prostate Cancer	1.3	1.8	5.2	0.4	-2.3	0.1
Age at First Birth	0.5	0.8	1.7	-0.7	1.3	-0.2
Bipolar Disorder (2011)	2.5	2.4	7.0	-2.6	-0.5	-0.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.1	-0.2	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.7	-1.3	-0.1	0.3
Crohns Disease (2012)	1.1	1.8	3.0	1.6	-1.7	-0.2
Mean Putamen Volume	0.3	0.4	0.4	-0.6	-0.7	0.5
Fasting Glucose	0.4	0.5	0.8	-0.9	-0.6	0.5
HbA1C	0.4	0.4	0.4	-0.6	-0.6	0.6
HDL Cholesterol	0.9	1.6	1.9	-1.4	1.3	-1.0
LDL Cholesterol	0.5	0.8	2.0	0.5	-1.4	-0.2
Lupus	1.6	2.4	3.2	-0.9	-1.7	-1.8
Neuroticism (2016)	0.3	0.5	1.3	0.3	0.3	-1.1
Primary Biliary Cirrhosis	2.6	3.6	9.9	0.7	-0.7	-3.2
Rheumatoid Arthritis	0.6	0.8	0.8	0.9	-0.9	-0.9
Schizophrenia (2014)	0.4	0.9	1.9	-1.4	0.6	-0.6
Triglycerides	1.1	1.8	3.5	1.9	-1.1	-0.7
Type 2 Diabetes (T2D) (2012)	2.4	2.7	4.1	0.8	-1.9	-2.0
Ulcerative Colitis	0.9	1.4	3.6	1.9	-0.7	-0.1
Blood Eosinophil Count	0.1	0.9	2.5	1.6	-0.3	0.0
Blood Platelet Count	0.4	4.7	10.2	0.5	1.9	3.2
Blood Red Count	0.0	0.2	0.4	-0.7	-0.2	0.4
Blood White Count	0.2	1.2	3.5	1.9	-0.3	-0.1
Heel T-Score	10.3	82.3	166.4	-1.0	-8.9	-12.9
BMI	0.2	1.3	3.4	0.1	1.8	0.7
Height	0.2	3.6	6.1	2.5	-1.8	-1.2
Waist Hip Ratio (WHR)	0.1	0.5	0.8	0.8	0.1	-0.9
Systolic Blood Pressure	0.0	0.1	0.2	0.4	0.2	0.3
Smoking Status	1.0	2.3	5.3	2.3	0.7	-1.1
Allergy or Eczema	1.6	4.3	7.6	2.8	-2.3	-0.3
Cardiovascular Disease	0.0	0.1	0.2	0.4	0.1	0.2
Hypothyroidism (self reported)	0.3	0.8	1.7	0.7	0.2	1.3
Respiratory disease	0.7	1.6	4.6	0.3	0.1	-2.1
Type 2 Diabetes (T2D) (2018)	2.1	4.0	6.9	2.6	0.2	-2.2
Lung FEV1/FVC ratio	0.1	0.6	1.3	0.2	0.8	1.1
Lung FVC	0.1	0.7	1.5	-0.5	-1.2	0.5
Neuroticism	1.1	2.7	3.2	-1.7	1.4	1.8
Chronotype (morning person)	1.4	3.3	8.5	-2.9	1.0	0.6
Hair Pigment	0.0	1.3	1.8	-1.3	1.3	0.6
Tanning	0.2	2.1	5.0	1.1	-0.2	2.2
Hand grip strength (left)	0.6	1.5	3.2	-0.7	-0.8	-1.8
Number of treatments/medications taken	0.9	1.7	4.1	2.0	-0.7	-0.7
Average weekly spirits intake	1.8	2.2	4.9	2.2	0.1	-1.3
Sensitivity / hurt feelings	0.1	0.2	0.2	0.5	-0.4	-0.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.2	1.1	1.0	0.7
Hearing difficulty/problems: Yes	1.3	2.0	5.0	-1.0	2.2	0.3
Relative age of first facial hair	0.5	1.0	2.3	-1.5	0.4	0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.9	1.7	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.6	0.9	-1.3	-1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.2	-0.5	-0.9
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.3	-0.0	-0.2
Eye problems/disorders: Diabetes related eye disease	4.6	5.1	10.3	3.2	-2.2	-0.2
Angina	1.0	1.3	2.3	1.3	-1.5	0.1
Medication for hormone replacement therapy	0.2	0.2	0.5	0.0	-0.4	-0.7
Vitamin and mineral supplements	0.6	0.8	1.8	-1.3	-0.7	-0.2
Supplements: Zinc	0.6	0.7	1.4	0.4	0.7	-1.2
Medication: Co-codamol	0.6	0.7	1.6	1.3	0.6	-0.4
Medication: Metformin	1.3	1.8	3.3	1.8	0.7	-1.3
Diabetes (father)	1.2	1.5	2.3	1.0	1.1	-1.5
Diabetes (mother)	1.2	1.5	3.4	-0.1	-1.1	-1.8
Severe depression (siblings)	1.9	2.1	3.2	1.8	1.8	0.4
Pack years adult smoking proportion	0.6	1.0	2.4	-0.7	0.1	1.6
Impedance of leg (right)	1.4	6.9	13.5	2.3	-3.7	-1.5
Leg fat-free mass (left)	0.3	1.7	4.0	-0.9	2.0	-0.6
Trunk fat percentage	0.3	1.0	2.9	1.7	-0.2	-0.4
Hand grip strength (right)	0.3	0.9	1.4	-1.2	-0.7	-0.9
Townsend deprivation index at recruitment	1.6	2.3	3.6	0.7	1.9	1.7
Current tobacco smoking	0.8	1.3	2.5	1.6	0.1	-1.2
Average weekly fortified wine intake	0.9	1.0	1.8	1.3	1.1	0.3
Maternal smoking around birth	0.5	0.7	1.6	-0.1	-0.8	-1.3
Fed-up feelings	0.3	0.6	1.1	-0.3	1.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.5	0.9	0.5
Relative age voice broke	0.7	1.1	2.5	-1.6	0.9	0.0
Taking other prescription medications	0.2	0.4	0.5	0.7	0.4	-0.7
Age when periods started (menarche)	0.5	1.1	2.9	-1.7	0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.5	-0.7	-0.0	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	6.8	15.4	25.3	-0.4	-4.5	-5.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.4	-1.2	0.3	1.0
Qualifications: CSEs or equivalent	1.3	1.7	4.0	0.7	-0.7	-2.0
Serious illness, injury or assault to yourself	1.2	1.4	3.2	-1.8	1.0	-0.2
High blood pressure	0.4	1.2	2.9	1.7	0.5	0.6
Hayfever, allergic rhinitis or eczema	1.3	2.9	4.6	2.1	-1.7	-1.1
Multivitamins +/- minerals	0.5	0.6	1.9	1.4	0.1	-0.0
Stomach or abdominal pain in last month	0.4	0.5	0.7	0.8	-0.7	-0.5
Supplements: Glucosamine	0.4	0.5	0.8	-0.9	0.8	-0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.7	0.1	-0.6	-1.6
Medication: Atenolol	2.2	2.7	4.3	0.7	-2.1	-1.8
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.5	0.6	-0.2
Sitting height	0.7	4.9	7.3	2.7	-1.8	-2.0
Chronic bronchitis/emphysema (father)	1.6	1.9	3.3	1.8	0.0	-1.5
High blood pressure (mother)	1.8	2.5	6.3	1.1	-0.2	-2.5
Body mass index (BMI)	0.3	1.1	3.4	-0.1	1.8	-0.0
Impedance of leg (left)	1.3	6.2	12.9	2.2	-3.6	-1.0
Leg predicted mass (left)	0.3	1.8	3.9	-1.0	2.0	-0.7
Trunk fat mass	0.2	0.7	1.6	1.3	0.4	-0.6
Waist circumference	0.3	1.2	2.3	1.1	1.5	0.0
Number of incorrect matches in round	0.3	0.6	0.8	0.8	0.9	0.5
Past tobacco smoking	2.2	4.1	11.6	-3.4	-0.8	0.3
Alcohol usually taken with meals	0.3	0.6	1.2	-0.2	0.6	1.1
Nervous feelings	0.3	0.5	0.9	0.7	0.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	1.0	0.7	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.3	0.6	0.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-1.0	-0.1	0.5
Had menopause	0.7	0.9	2.4	1.5	-0.3	0.5
Had other major operations	2.8	3.4	9.2	0.9	-0.4	-3.0
Forced vital capacity (FVC)	0.1	0.3	0.7	-0.4	-0.8	0.2
Heel bone mineral density (BMD) T-score, automated (right)	5.7	13.2	22.8	-0.1	-4.1	-4.8
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.6	1.1	0.0	1.3
Qualifications: None of the above	0.5	1.2	1.8	1.3	-0.3	1.3
Financial difficulties in last 2 years	0.3	0.4	0.7	0.5	0.3	0.9
Mouth/teeth dental problems	0.3	0.5	1.1	0.5	-1.1	0.2
Heart attack	1.5	1.9	2.8	-0.6	1.6	1.7
Allergy	1.8	4.2	5.6	-2.4	1.5	2.2
Pain all over the body in last month	1.5	1.6	2.7	-1.6	0.4	1.4
Diabetes (self-reported)	1.5	2.3	5.8	2.4	0.2	-1.0
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	6.9	0.2	-2.6	-1.2
Medication: Ramipril	0.7	0.9	1.7	1.3	-0.5	0.8
Medication: Simvastatin	0.9	1.3	3.4	1.8	-0.6	-0.3
Fluid intelligence score	0.2	0.5	1.1	-0.7	-0.1	-1.0
Illnesses of siblings	0.6	0.8	1.3	-1.2	-0.9	0.4
Neuroticism score	0.5	1.0	1.5	-0.9	1.2	0.9
Weight	0.2	0.9	2.3	0.2	1.5	-0.6
Impedance of arm (right)	0.8	3.6	6.5	2.1	-2.5	-0.0
Arm fat percentage (right)	0.1	0.6	1.0	0.8	1.0	0.1
Trunk fat-free mass	0.4	2.1	4.4	-1.0	2.1	-0.9
Hip circumference	0.1	0.5	1.1	0.7	1.0	0.0
Time employed in main current job	0.3	0.4	0.7	0.8	-0.5	0.4
Alcohol intake versus 10 years previously	3.2	4.7	7.8	-2.1	-2.8	-1.4
Father’s age at death	0.3	0.4	1.0	0.5	0.2	-1.0
Worrier / anxious feelings	1.2	2.2	3.0	-1.7	1.6	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	1.8	1.3	1.2	-0.6
Falls in the last year	2.2	3.0	6.8	-2.6	1.2	0.9
Hair/balding pattern: Pattern 3	0.3	0.5	0.5	0.6	0.7	0.7
Number of live births	0.3	0.4	0.8	0.4	0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.8	-0.9	-0.5	0.5
Pulse rate	0.1	0.2	0.4	-0.6	-0.2	0.5
Happiness	2.4	2.9	6.7	-0.6	2.6	1.3
Noisy workplace	0.8	0.9	2.5	0.4	1.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.2	-0.4	1.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	-1.0	0.7	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	-0.5	0.7	-0.3
Asthma	0.9	1.9	4.8	0.8	-0.3	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.9	-0.3	0.2	-2.4
Medication: Cholesterol lowering	0.8	1.2	2.5	1.6	-0.8	0.6
Depression (self-reported)	0.1	0.1	0.2	-0.3	0.4	0.4
Medication: Lansoprazole	1.0	1.1	3.2	0.0	-0.4	-1.8
Prospective memory result	0.2	0.2	0.3	0.6	0.4	-0.3
Lung cancer (father)	0.8	0.9	2.2	0.8	-0.3	-1.5
Illnesses of mother	0.9	1.2	1.8	-0.4	-1.3	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.1	-1.1	-0.4	0.4
Pulse wave Arterial Stiffness index	2.5	2.9	4.5	2.1	0.2	-2.1
Impedance of arm (left)	0.6	2.9	5.3	1.8	-2.3	0.0
Arm fat mass (right)	0.2	0.6	1.7	0.4	1.3	-0.3
Trunk predicted mass	0.4	2.1	4.4	-1.1	2.1	-0.9
Standing height	0.1	1.0	2.1	0.7	-0.6	-1.4
Length of working week for main job	1.4	1.5	3.8	-1.9	0.9	0.1
Exposure to tobacco smoke at home	1.0	1.1	2.0	-0.0	1.4	1.1
Breastfed as a baby	1.7	2.1	4.6	-0.2	1.2	2.1
Tense / ‘highly strung’	0.4	0.6	0.8	0.8	0.9	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.2	1.8	0.1	-0.1
Hair/balding pattern: Pattern 4	0.3	0.8	1.3	-1.1	1.1	-0.1
Birth weight of first child	0.2	0.3	0.6	-0.0	0.5	0.8
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.4	-0.1	-0.7
Pulse wave reflection index	0.4	0.5	1.0	0.6	0.6	-1.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.1	-1.4	1.0	0.6
Loud music exposure frequency	0.2	0.2	0.3	-0.0	-0.5	-0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.3	-0.3	1.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.3	0.7	0.8
Blood clot in the leg (DVT)	0.4	0.6	1.1	1.0	0.5	-0.7
Medication: Paracetamol	1.0	1.6	1.9	1.2	-1.3	-1.4
Headache pain in last month	3.0	5.1	7.6	2.8	-2.4	-1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.7	-1.1	0.3	-1.7
Glaucoma (self-reported)	0.7	0.8	1.8	1.3	-0.6	-0.4
Gout (self-reported)	0.0	0.1	0.1	0.2	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.7	0.5	0.8
Medication: Amlodipine	0.4	0.5	1.0	0.7	0.0	-1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.6	-0.4	1.6	-0.2
Birth weight	0.1	0.2	0.6	-0.3	0.2	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	-1.3	0.2	0.8
High blood pressure (siblings)	0.1	0.2	0.3	0.5	0.3	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	-0.8	-0.4	0.3
Body fat percentage	0.2	0.9	2.5	1.6	0.2	-0.4
Leg fat percentage (right)	0.2	0.8	1.8	1.3	0.1	-0.8
Arm fat-free mass (right)	0.4	2.0	3.4	-1.2	1.8	-1.1
Exposure to tobacco smoke outside home	0.4	0.6	0.9	-0.9	0.9	-0.1
Comparative body size at age 10	1.1	3.0	5.6	-0.2	2.4	1.9
Number of full brothers	0.4	0.5	1.0	-0.3	1.0	0.6
Worry too long after embarrassment	0.1	0.2	0.6	0.8	0.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	1.4	-0.7	0.7
Wheeze or whistling in the chest in last year	1.2	2.1	4.9	1.1	-0.5	-2.2
Number of children fathered	0.9	1.1	1.7	0.1	1.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.3	1.0	-1.5	-1.3
Age at first live birth	0.2	0.3	0.5	-0.6	0.7	0.0
Pulse wave peak to peak time	2.2	2.6	4.1	-2.0	-0.2	2.0
Health satisfaction	1.3	1.7	2.2	1.4	1.5	-0.8
Shortness of breath walking on level ground	0.8	0.9	1.3	-0.5	1.1	1.1
Qualifications: College or University degree	1.4	4.5	11.0	-0.9	3.3	1.3
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.5	0.4	0.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	2.9	0.7	1.7	1.5
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	-0.5	0.2
Medication for pain relief, constipation, heartburn	2.6	4.5	7.8	-1.1	2.1	2.8
Neck or shoulder pain in last month	0.6	0.9	1.8	0.9	-0.3	-1.3
Medication: Blood pressure	0.8	1.5	3.5	0.7	0.7	1.9
Angina (self-reported)	0.9	1.2	2.0	1.2	-1.4	-0.0
Migraine (self-reported)	0.3	0.4	0.6	-0.8	-0.1	0.7
Medication: Ibuprofen	0.3	0.4	0.9	-0.1	0.5	-1.0
Medication: Allopurinol	1.0	1.4	3.1	0.9	0.4	-1.8
Medication: Omeprazole	0.3	0.3	0.9	-0.2	-0.9	-0.2
Medication: Seretide 50 evohaler	0.5	0.6	1.0	0.4	1.0	-0.7
Mean time to correctly identify matches	0.7	1.4	3.4	0.9	-0.1	1.8
Heart disease (mother)	0.9	1.0	2.3	0.1	1.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	0.1	1.3	0.5
Whole body fat mass	0.1	0.6	0.9	0.9	0.9	-0.3
Leg fat mass (right)	0.2	0.6	0.9	0.5	0.9	-0.9
Arm predicted mass (right)	0.4	1.8	2.7	-1.0	1.6	-1.4
Pulse rate, automated reading	0.3	1.1	1.8	1.4	-1.1	0.4
Alcohol intake frequency.	0.8	1.8	2.5	-1.2	-1.6	1.3
Comparative height size at age 10	0.0	0.2	0.6	0.3	-0.2	-0.7
Number of full sisters	0.3	0.4	1.2	-0.3	-0.1	1.1
Suffer from ‘nerves’	1.2	1.9	4.9	-0.7	2.2	0.5
Overall health rating	0.6	1.3	3.0	0.6	1.7	0.7
Chest pain or discomfort	0.2	0.3	0.9	0.4	0.1	-0.9
Had major operations	0.3	0.4	1.1	0.1	1.1	-0.2
Age at last live birth	0.9	1.4	2.0	-1.1	1.4	0.9
Family relationship satisfaction	0.3	0.4	1.0	-0.4	-0.1	1.0
Leg pain on walking	0.9	1.1	1.7	-1.3	1.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.4	-0.3	-0.5	-1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.0	-0.4	-0.5	-1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	0.9	-0.0	0.9
Medication: Aspirin	1.8	2.4	5.3	0.4	-2.3	-1.3
Supplements: Vitamin C	0.4	0.5	0.5	0.7	0.7	0.7
Knee pain experienced in last month	1.0	1.6	2.7	1.3	-0.6	-1.6
Hypertension (Self-reported)	0.3	0.9	1.5	1.2	0.7	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.8	1.0	-0.3
Illnesses of father: Heart disease	0.3	0.4	0.8	-0.1	0.7	0.9
Illnesses of siblings: Diabetes	1.7	2.1	3.6	1.9	1.1	-1.1
Smoking status: Previous	1.3	1.9	4.8	2.2	0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.3	-0.3	0.4
Whole body fat-free mass	0.4	2.1	4.6	-1.0	2.1	-0.8
Leg fat-free mass (right)	0.4	2.1	4.8	-1.1	2.2	-0.4
Arm fat percentage (left)	0.1	0.6	1.4	0.6	1.2	-0.0
Average weekly red wine intake	1.7	2.5	5.8	2.4	0.4	-1.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.5	-0.7	0.5	-0.5
Mood swings	0.3	0.5	1.0	-0.6	1.0	0.0
Loneliness, isolation	0.5	0.7	1.9	-0.1	0.4	1.4
Long-standing illness, disability or infirmity	0.5	0.8	1.1	1.0	-0.6	-1.1
Ever had bowel cancer screening	0.3	0.3	0.6	0.3	0.6	-0.8
Diabetes diagnosed by doctor	1.2	1.9	5.0	2.2	-0.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.3	-0.6	0.2	-2.1
Friendships satisfaction	1.1	1.3	3.2	0.3	1.8	0.9
Qualifications: nursing, teaching	1.0	1.6	2.4	-1.5	1.6	-0.1
Commuting to job workplace: Walk	0.5	0.5	0.9	0.1	0.8	1.0
Eye problems/disorders: Cataract	1.5	1.7	4.4	-0.7	2.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	0.2	-0.4	-0.6
Medication for cholesterol	1.0	1.6	2.2	-1.2	1.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-1.1	-0.5	-0.6
Back pain experienced in last month	3.1	4.5	5.9	2.2	-2.4	-1.6
Mineral and other dietary supplements	0.7	0.9	1.7	1.3	-0.3	-1.0
Breast cancer (self-reported)	0.3	0.3	1.0	0.2	0.2	1.0
Asthma (self-reported)	1.2	2.4	6.0	1.0	-0.4	-2.5
Osteoporosis (self-reported)	0.1	0.1	0.1	0.2	0.3	-0.2
Osteoarthritis (self-reported)	0.7	0.9	2.2	-0.4	-0.6	-1.5
Medication: Aspirin	1.3	1.7	3.2	0.7	-1.8	-1.2
Medication: Gliclazide	2.3	2.6	3.8	1.9	-1.3	-1.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.0	-0.8	0.4	-1.0
Smoking status: Current	1.0	1.6	3.1	1.8	0.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	3.6	-1.9	1.2	1.8
Whole body water mass	0.4	2.2	4.8	-1.1	2.2	-0.7
Leg predicted mass (right)	0.4	2.0	4.6	-1.1	2.1	-0.3
Arm fat mass (left)	0.2	0.8	2.1	0.4	1.4	-0.1
Number of self-reported non-cancer illnesses	1.1	1.9	5.5	0.4	-0.4	-2.3
Average weekly champagne plus white wine intake	0.5	0.6	1.4	0.4	-0.6	1.2
Miserableness	0.3	0.5	0.7	-0.8	0.8	0.3
Guilty feelings	1.0	1.5	2.9	0.1	1.7	1.3
Wears glasses or contact lenses	1.4	1.6	2.7	1.1	-1.7	-0.9
Ever taken oral contraceptive pill	0.3	0.3	0.8	0.2	0.9	0.4
Hearing aid user	0.6	0.7	0.8	0.8	-0.9	-0.8
Mother’s age at death	0.5	0.6	1.5	-0.1	-0.6	-1.2
Financial situation satisfaction	0.8	1.0	2.1	0.3	0.9	1.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.7	0.0	0.1
Commuting to job workplace: Public transport	0.3	0.4	0.5	-0.6	-0.4	0.7
Eye problems/disorders: Glaucoma	1.1	1.3	1.7	1.2	-1.3	-0.8
Medication: Blood pressure	0.4	0.7	1.7	1.3	-0.4	-0.5
Pain type(s) experienced in last month: Hip pain	2.3	2.9	7.2	-0.6	1.1	-2.7
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.5	-0.9	-1.2	-0.0
High cholesterol (Self-reported)	0.6	1.0	1.4	0.9	-0.9	-1.2
Medication: Bendroflumethiazide	0.6	1.0	2.9	1.7	-0.0	0.0
Medication: Paracetamol	0.8	1.3	2.3	1.1	-0.5	-1.5
Medication: Lisinopril	0.0	0.0	0.1	-0.3	-0.1	0.2
Medication: Atorvastatin	0.2	0.2	0.6	-0.1	-0.8	-0.1
Illnesses of father: High blood pressure	0.5	0.7	0.8	0.9	-0.8	-0.8
Alcohol drinker status: Never	0.1	0.1	0.1	-0.4	-0.4	0.3
Ever smoked	2.2	3.8	9.5	3.1	1.4	-0.1
Basal metabolic rate	0.3	1.7	4.0	-0.7	2.0	-0.8
Leg fat percentage (left)	0.2	0.6	1.7	1.3	0.3	-0.3
Arm fat-free mass (left)	0.2	1.2	2.6	-0.7	1.6	-0.8
Number of operations (self-reported)	0.6	0.9	2.6	0.1	0.0	-1.6
Average weekly beer plus cider intake	0.5	0.7	0.9	0.9	-1.0	-0.6
Irritability	0.8	1.4	3.1	-0.8	1.8	0.8
Risk taking	1.4	2.1	5.4	2.3	-0.6	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	0.6	0.2	-1.2
Fractured/broken bones in last 5 years	3.4	4.3	9.0	0.4	2.0	3.0
Age started oral contraceptive pill	0.3	0.3	0.7	0.5	-0.2	0.9
Diastolic blood pressure, automated reading	0.3	1.1	1.5	-1.0	1.2	0.9
Ever depressed for a whole week	0.3	0.4	0.8	0.9	-0.5	-0.1
Unable to work because of sickness or disability	0.3	0.4	0.7	0.8	0.5	0.6
Commuting to job workplace: Cycle	0.5	0.6	1.4	-0.5	-0.2	-1.2
Myopia	0.6	0.8	1.3	0.6	1.1	0.9
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.3	-1.8	-0.2	-1.3
Cholesterol lowering medication	0.7	1.1	1.7	1.0	-0.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.2	-0.7	-0.6
Pain experienced in last month	1.6	2.7	4.6	-0.1	1.9	2.1
Supplements: Calcium	1.3	1.4	2.5	-0.9	0.9	1.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.4	-0.7	0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.7	-0.4	1.4	1.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.3	1.5	0.2	-0.3
Heart disease (siblings)	0.3	0.4	1.0	-0.1	1.0	0.4
Alcohol drinker status: Previous	1.8	2.1	2.9	1.1	-1.7	1.4
Pack years of smoking	0.4	0.6	1.7	-0.4	0.1	1.3
Impedance of whole body	1.3	6.6	13.0	2.5	-3.6	-0.6
Leg fat mass (left)	0.1	0.6	1.1	0.4	1.1	-0.6
Arm predicted mass (left)	0.2	0.9	1.8	-0.5	1.3	-0.7