Hub : Genes

FZD4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.127 0.046 0.0026 0.037 NA 0.045 NA 0.048 5.4e-04 NA 0.00014 NA 8.4e-05
2 GTEx Cells Transformed fibroblasts 0.069 0.028 0.0036 0.070 NA 0.038 NA 0.046 6.5e-06 NA 0.00074 NA 2.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.0 2.0 -1.4 -0.3
Bipolar Disorder or Schizophrenia 0.6 1.4 2.6 0.4 -1.6
Depressed Affect (Nagel 2018) 1.3 2.7 5.3 -2.3 0.2
Depression (Nagel 2018) 0.0 0.0 0.0 0.2 -0.1
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.1 -0.3 -1.0
Neuroticism (Nagel 2018) 0.9 2.1 2.9 -1.7 -1.1
Schizophrenia (2018) 1.5 3.1 3.3 1.7 -1.8
Schizophrenia vs Biploar Disorder 1.8 2.3 4.6 2.1 -0.2
Worry (Nagel 2018) 0.0 0.1 0.1 -0.2 -0.4
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -0.9 0.3
Alzheimer’s Disease (in father) 0.4 0.4 0.8 0.9 0.2
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 0.2 0.6
Crohns Disease (2017) 0.6 1.3 2.6 1.6 -0.1
Irritable Bowel Disease (IBD) 0.2 0.4 0.6 0.8 -0.4
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.6 0.2
Major Depression (MDD) 0.1 0.1 0.2 -0.1 0.4
Reaction Time 0.1 0.1 0.2 0.2 -0.5
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.9 0.4 -1.0
Breast Cancer 0.2 0.4 0.6 0.5 0.8
Ovarian Cancer 3.5 4.6 7.5 -2.7 -1.3
Prostate Cancer 3.1 4.3 5.3 -2.3 1.8
Age at First Birth 0.5 0.7 1.4 -0.2 1.2
Bipolar Disorder (2011) 0.6 0.6 1.1 0.3 -1.1
Body Mass Index (BMI) (2010) 0.5 0.7 1.2 -1.1 -0.4
Coronary Artery Disease (CAD) 1.9 2.2 3.6 1.9 -0.9
Crohns Disease (2012) 0.6 1.0 1.9 1.4 0.3
Mean Putamen Volume 0.4 0.4 0.7 0.3 0.8
Fasting Glucose 0.8 0.9 1.8 -1.4 0.1
HbA1C 0.3 0.3 0.4 -0.6 0.6
HDL Cholesterol 0.9 1.5 2.3 0.8 -1.5
LDL Cholesterol 1.0 1.6 1.6 -1.3 1.2
Lupus 1.0 1.6 2.3 -1.5 -0.9
Neuroticism (2016) 0.8 1.2 2.2 -1.5 -0.4
Primary Biliary Cirrhosis 0.4 0.6 1.0 -1.0 0.5
Rheumatoid Arthritis 0.1 0.1 0.3 -0.1 -0.5
Schizophrenia (2014) 1.0 2.2 2.8 1.3 -1.7
Triglycerides 1.8 3.0 3.9 -2.0 1.4
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.2 0.7 2.0
Ulcerative Colitis 0.2 0.2 0.2 0.5 0.5
Blood Eosinophil Count 0.1 0.8 1.3 -1.2 0.5
Blood Platelet Count 0.0 0.4 0.7 -0.8 0.1
Blood Red Count 0.0 0.4 0.7 -0.8 0.3
Blood White Count 0.2 1.3 2.5 -1.6 0.4
Heel T-Score 7.4 58.6 112.4 -2.2 -10.6
BMI 0.7 4.2 6.0 -2.5 -1.6
Height 0.4 7.5 9.7 -3.1 2.3
Waist Hip Ratio (WHR) 0.5 2.3 3.5 -1.9 1.1
Systolic Blood Pressure 0.4 2.0 4.0 -0.1 2.0
Smoking Status 1.5 3.6 7.2 -2.7 -0.3
Allergy or Eczema 0.1 0.2 0.2 -0.5 -0.3
Cardiovascular Disease 0.0 0.0 0.0 0.1 0.1
Hypothyroidism (self reported) 1.4 3.2 6.3 -2.5 -0.3
Respiratory disease 0.1 0.2 0.3 -0.5 0.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.9 -0.2 1.4
Lung FEV1/FVC ratio 0.1 0.4 0.8 0.1 0.9
Lung FVC 0.0 0.2 0.3 0.5 0.2
Neuroticism 0.4 0.9 1.7 -1.3 -0.4
Chronotype (morning person) 0.3 0.7 1.1 0.6 -1.0
Hair Pigment 0.2 7.0 12.0 -1.4 -3.5
Tanning 0.2 2.8 4.9 -0.9 2.2
Hand grip strength (left) 0.1 0.2 0.4 -0.2 0.6
Number of treatments/medications taken 2.5 4.4 8.3 -0.8 2.9
Average weekly spirits intake 0.1 0.1 0.2 0.1 -0.5
Sensitivity / hurt feelings 0.3 0.4 0.8 0.9 -0.3
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.2 -1.1 -0.0
Hearing difficulty/problems: Yes 1.0 1.6 2.8 -1.7 -0.6
Relative age of first facial hair 0.4 0.8 1.7 0.1 -1.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.1 0.9
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.7 -0.7 -0.9
Ever had hysterectomy (womb removed) 1.7 1.9 2.9 1.7 1.0
Systolic blood pressure, automated reading 0.2 0.7 1.1 -0.6 1.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.4 -0.6 0.6
Angina 0.7 1.0 1.4 -1.2 0.7
Medication for hormone replacement therapy 0.5 0.6 1.1 0.0 1.1
Vitamin and mineral supplements 1.1 1.5 1.8 -1.0 -1.4
Supplements: Zinc 0.3 0.3 0.6 0.8 -0.2
Medication: Co-codamol 0.2 0.3 0.5 0.7 0.0
Medication: Metformin 0.1 0.2 0.2 0.5 0.4
Diabetes (father) 0.4 0.4 0.8 0.9 -0.2
Diabetes (mother) 0.7 0.9 1.7 -0.3 1.3
Severe depression (siblings) 0.0 0.0 0.0 -0.1 0.0
Pack years adult smoking proportion 0.1 0.1 0.2 0.0 0.5
Impedance of leg (right) 0.3 1.4 2.8 -0.0 1.7
Leg fat-free mass (left) 0.2 0.8 1.4 -1.2 -0.5
Trunk fat percentage 0.3 1.4 2.3 -1.5 -0.6
Hand grip strength (right) 0.2 0.5 0.8 -0.9 0.3
Townsend deprivation index at recruitment 1.0 1.4 1.5 -1.2 -1.1
Current tobacco smoking 0.2 0.4 0.5 -0.7 -0.5
Average weekly fortified wine intake 1.4 1.6 1.8 -1.2 1.3
Maternal smoking around birth 0.7 1.0 1.9 -1.4 0.3
Fed-up feelings 1.4 2.6 5.2 -2.3 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 0.3 0.4
Relative age voice broke 1.5 2.3 3.7 0.9 -1.9
Taking other prescription medications 2.7 4.2 8.4 -2.9 -0.0
Age when periods started (menarche) 4.1 9.9 16.2 -4.0 -1.9
Bilateral oophorectomy (both ovaries removed) 2.2 2.5 4.0 -1.0 -2.0
Heel bone mineral density (BMD) T-score, automated (left) 6.1 13.9 22.2 -2.4 -4.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.4 -0.5 1.2
Qualifications: CSEs or equivalent 1.9 2.5 4.7 2.2 0.5
Serious illness, injury or assault to yourself 0.3 0.3 0.5 -0.7 -0.3
High blood pressure 0.0 0.1 0.1 -0.3 0.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.7 -0.9 -0.6
Multivitamins +/- minerals 0.9 1.2 2.3 1.5 0.2
Stomach or abdominal pain in last month 1.6 2.0 4.0 -2.0 -0.0
Supplements: Glucosamine 1.0 1.3 2.4 0.5 -1.5
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 0.2 1.0
Medication: Atenolol 0.1 0.1 0.2 0.5 -0.2
Medication: Levothyroxine sodium 0.4 0.7 1.3 -1.2 0.4
Sitting height 0.7 4.7 5.6 -1.9 2.4
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.4 -0.1
High blood pressure (mother) 0.1 0.1 0.3 -0.0 -0.5
Body mass index (BMI) 0.4 1.6 2.1 -1.1 -1.4
Impedance of leg (left) 0.2 1.0 2.0 0.2 1.4
Leg predicted mass (left) 0.2 0.8 1.4 -1.2 -0.5
Trunk fat mass 0.5 2.3 3.9 -2.0 -0.8
Waist circumference 0.6 2.3 3.8 -1.9 -0.9
Number of incorrect matches in round 0.3 0.5 0.5 -0.7 0.7
Past tobacco smoking 0.6 1.0 1.9 1.4 -0.4
Alcohol usually taken with meals 0.9 1.4 1.8 1.3 -1.0
Nervous feelings 0.9 1.6 3.2 -0.1 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.5 -0.7 -0.1
Hearing difficulty/problems with background noise 0.4 0.7 1.4 -1.2 -0.0
Hair/balding pattern: Pattern 2 0.4 0.5 1.1 -1.0 -0.1
Had menopause 0.6 0.8 1.1 1.0 0.7
Had other major operations 0.4 0.5 1.0 -0.3 1.0
Forced vital capacity (FVC) 0.1 0.3 0.5 -0.7 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 6.3 14.5 23.3 -2.4 -4.8
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 4.1 2.0 -0.6
Qualifications: None of the above 1.2 2.6 4.6 0.8 2.1
Financial difficulties in last 2 years 0.4 0.6 0.8 0.5 -0.9
Mouth/teeth dental problems 2.7 4.1 5.2 2.3 1.8
Heart attack 2.0 2.5 2.8 -1.5 -1.7
Allergy 0.7 1.6 3.1 1.8 0.2
Pain all over the body in last month 0.4 0.4 0.8 0.3 -0.9
Diabetes (self-reported) 0.4 0.6 0.7 0.7 0.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.9 -0.9 -0.1
Medication: Ramipril 0.0 0.0 0.0 0.1 -0.1
Medication: Simvastatin 0.3 0.4 0.7 -0.3 0.9
Fluid intelligence score 0.1 0.2 0.3 0.6 0.1
Illnesses of siblings 0.0 0.0 0.1 0.1 0.3
Neuroticism score 0.6 1.3 2.7 -1.6 0.0
Weight 0.4 1.9 3.0 -1.7 -0.9
Impedance of arm (right) 0.2 0.9 1.4 -0.6 1.2
Arm fat percentage (right) 0.5 1.8 2.9 -1.7 -0.9
Trunk fat-free mass 0.2 1.2 2.4 -1.5 -0.2
Hip circumference 0.1 0.5 0.7 -0.8 -0.5
Time employed in main current job 0.7 0.8 1.0 -1.0 0.8
Alcohol intake versus 10 years previously 1.0 1.5 2.7 1.6 -0.4
Father’s age at death 0.3 0.4 0.7 -0.4 0.8
Worrier / anxious feelings 0.5 0.9 1.1 -1.0 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 -0.3 0.5
Falls in the last year 0.6 0.8 1.4 0.4 1.2
Hair/balding pattern: Pattern 3 1.2 1.7 2.5 -1.0 -1.6
Number of live births 1.7 2.4 4.8 -0.0 2.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 -0.3 -0.3
Pulse rate 1.7 2.9 3.2 1.8 1.6
Happiness 0.3 0.4 0.5 -0.6 -0.7
Noisy workplace 0.7 0.9 1.4 -0.6 -1.2
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.5 -1.6 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.1 1.1 -0.0
Mouth/teeth dental problems: Dentures 1.6 2.7 5.0 -2.2 -0.7
Asthma 0.3 0.6 0.8 -0.9 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.5 0.4 0.7
Medication: Cholesterol lowering 0.1 0.2 0.3 -0.6 0.3
Depression (self-reported) 0.2 0.2 0.3 -0.3 -0.6
Medication: Lansoprazole 1.0 1.2 1.4 -0.9 -1.2
Prospective memory result 1.0 1.2 2.3 0.4 -1.5
Lung cancer (father) 2.9 3.4 6.7 -0.5 2.6
Illnesses of mother 1.7 2.1 2.9 1.7 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 -0.8 0.1
Pulse wave Arterial Stiffness index 0.6 0.7 1.1 -0.5 1.0
Impedance of arm (left) 0.1 0.5 0.6 -0.6 0.8
Arm fat mass (right) 0.5 2.1 3.2 -1.8 -0.9
Trunk predicted mass 0.2 1.3 2.5 -1.6 -0.2
Standing height 0.2 2.4 3.3 -1.8 1.2
Length of working week for main job 6.3 7.0 8.0 -2.4 -2.8
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.2 -0.4
Breastfed as a baby 0.8 1.0 1.6 1.3 0.7
Tense / ‘highly strung’ 0.7 1.2 2.1 0.5 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.5 -1.2 -0.6
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 -0.5 -0.4
Birth weight of first child 0.5 0.9 1.0 0.9 1.0
Peak expiratory flow (PEF) 0.3 0.7 0.9 -1.0 -0.7
Pulse wave reflection index 0.4 0.4 0.5 -0.7 -0.6
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.5 0.7 -0.3
Loud music exposure frequency 1.4 1.5 2.1 -1.4 -1.0
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.2 -0.5 0.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.8 -0.9 0.3
Blood clot in the leg (DVT) 0.4 0.5 0.5 -0.6 0.7
Medication: Paracetamol 0.9 1.5 2.9 -0.4 1.7
Headache pain in last month 0.6 1.0 1.5 -0.7 1.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.8 0.5 -0.9
Glaucoma (self-reported) 1.3 1.6 3.0 0.4 1.7
Gout (self-reported) 1.2 1.6 2.5 -0.8 -1.6
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 5.3 -2.3 1.0
Medication: Amlodipine 0.4 0.6 1.0 -1.0 0.4
Medication: Ventolin 100micrograms inhaler 1.2 1.6 3.2 -1.8 -0.1
Birth weight 0.6 1.4 2.7 -1.6 0.2
Chronic bronchitis/emphysema (mother) 2.2 2.6 5.0 -2.2 -0.3
High blood pressure (siblings) 0.3 0.4 0.7 0.8 -0.3
Forced vital capacity (FVC), Best measure 0.3 1.1 2.2 -1.5 0.2
Body fat percentage 0.4 1.5 2.3 -1.5 -0.8
Leg fat percentage (right) 0.3 0.9 1.4 -1.2 -0.6
Arm fat-free mass (right) 0.1 0.6 1.0 -1.0 -0.5
Exposure to tobacco smoke outside home 0.3 0.4 0.7 -0.8 -0.1
Comparative body size at age 10 0.1 0.3 0.4 0.6 -0.4
Number of full brothers 1.1 1.4 1.6 -1.1 1.3
Worry too long after embarrassment 0.2 0.3 0.5 -0.7 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.4 -1.2 0.0
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 -0.3 0.2
Number of children fathered 0.3 0.3 0.6 0.8 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.5 -0.0 0.7
Age at first live birth 0.1 0.1 0.2 0.4 0.1
Pulse wave peak to peak time 0.5 0.5 1.0 0.2 -1.0
Health satisfaction 0.1 0.1 0.2 -0.4 0.3
Shortness of breath walking on level ground 0.7 0.8 1.0 1.0 -0.8
Qualifications: College or University degree 0.6 2.0 3.4 -0.7 -1.8
Eye problems/disorders: None of the above 0.0 0.0 0.1 -0.0 0.3
Mouth/teeth dental problems: Loose teeth 1.1 1.3 1.7 -1.3 -0.9
Emphysema/chronic bronchitis 0.8 0.9 1.4 0.6 1.2
Medication for pain relief, constipation, heartburn 0.9 1.6 2.8 0.6 -1.7
Neck or shoulder pain in last month 2.3 3.2 6.1 -0.6 2.5
Medication: Blood pressure 0.4 0.8 1.5 0.1 1.2
Angina (self-reported) 1.0 1.3 1.4 -1.2 1.1
Migraine (self-reported) 0.1 0.1 0.2 0.2 0.4
Medication: Ibuprofen 0.8 1.0 1.7 0.5 1.3
Medication: Allopurinol 0.9 1.2 1.6 -1.3 -0.8
Medication: Omeprazole 0.2 0.3 0.6 -0.7 -0.2
Medication: Seretide 50 evohaler 2.6 3.0 6.1 0.2 -2.5
Mean time to correctly identify matches 0.0 0.1 0.1 -0.3 -0.1
Heart disease (mother) 1.5 1.9 2.5 -1.1 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 3.6 -1.3 -1.9
Whole body fat mass 0.6 2.3 3.7 -1.9 -0.9
Leg fat mass (right) 0.3 1.3 2.0 -1.4 -0.8
Arm predicted mass (right) 0.1 0.8 1.1 -1.0 -0.7
Pulse rate, automated reading 0.1 0.5 0.7 0.5 0.8
Alcohol intake frequency. 1.1 2.5 4.9 2.2 0.1
Comparative height size at age 10 0.8 4.2 5.7 -1.6 2.4
Number of full sisters 2.2 2.7 5.0 2.2 0.6
Suffer from ‘nerves’ 0.4 0.6 0.6 0.8 -0.8
Overall health rating 0.0 0.1 0.1 -0.2 0.3
Chest pain or discomfort 0.3 0.4 0.5 -0.7 0.5
Had major operations 0.4 0.4 0.8 -0.9 0.2
Age at last live birth 0.4 0.6 1.2 -1.1 -0.2
Family relationship satisfaction 1.0 1.3 1.5 -1.1 -1.2
Leg pain on walking 0.2 0.3 0.4 0.3 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 3.4 -1.9 0.6
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.4 0.4 0.6
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.2 -0.1
Medication: Aspirin 1.1 1.5 2.8 0.5 1.7
Supplements: Vitamin C 0.0 0.0 0.1 -0.2 0.2
Knee pain experienced in last month 0.9 1.4 1.9 -0.9 1.4
Hypertension (Self-reported) 0.0 0.1 0.1 0.3 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 -0.4 0.2
Illnesses of father: Heart disease 2.9 4.1 5.7 -2.4 -1.6
Illnesses of siblings: Diabetes 0.5 0.6 1.1 1.1 0.1
Smoking status: Previous 0.7 1.1 1.9 -1.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.2 5.1 -2.3 -1.1
Whole body fat-free mass 0.2 1.0 2.0 -1.4 -0.3
Leg fat-free mass (right) 0.1 0.7 1.0 -1.0 -0.6
Arm fat percentage (left) 0.5 2.1 2.7 -1.6 -1.2
Average weekly red wine intake 0.6 0.9 1.6 1.3 0.4
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.1 -0.3 1.0
Mood swings 0.7 1.2 2.3 -1.5 -0.4
Loneliness, isolation 0.5 0.6 1.2 -1.1 -0.3
Long-standing illness, disability or infirmity 0.7 1.1 2.3 -1.5 0.0
Ever had bowel cancer screening 0.4 0.5 1.0 -1.0 0.1
Diabetes diagnosed by doctor 0.7 1.2 2.1 0.6 1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 2.2 -0.2 1.5
Friendships satisfaction 0.1 0.1 0.3 0.1 -0.5
Qualifications: nursing, teaching 0.1 0.2 0.3 -0.1 -0.6
Commuting to job workplace: Walk 0.3 0.4 0.6 -0.8 0.3
Eye problems/disorders: Cataract 0.9 1.1 1.4 0.8 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.1 -0.5 -1.0
Medication for cholesterol 0.7 1.1 1.2 1.0 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.4 1.2 0.2
Back pain experienced in last month 0.1 0.1 0.2 -0.2 0.5
Mineral and other dietary supplements 0.1 0.1 0.2 -0.5 -0.2
Breast cancer (self-reported) 1.1 1.4 2.6 -1.6 0.4
Asthma (self-reported) 0.2 0.3 0.5 -0.7 -0.4
Osteoporosis (self-reported) 0.8 0.9 1.8 0.2 1.4
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.5 0.2
Medication: Aspirin 1.3 1.7 2.7 0.8 1.6
Medication: Gliclazide 0.0 0.0 0.0 0.0 0.2
Illnesses of father: None of the above (group 1) 0.6 0.7 1.3 0.4 1.1
Smoking status: Current 0.2 0.4 0.7 -0.9 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.4 1.2 -0.3
Whole body water mass 0.2 1.0 1.9 -1.4 -0.4
Leg predicted mass (right) 0.1 0.6 0.9 -1.0 -0.6
Arm fat mass (left) 0.7 2.9 4.0 -2.0 -1.3
Number of self-reported non-cancer illnesses 1.0 1.7 2.2 -1.5 1.1
Average weekly champagne plus white wine intake 0.1 0.1 0.3 -0.5 -0.1
Miserableness 1.5 2.6 5.2 -2.3 -0.1
Guilty feelings 1.3 2.0 3.9 -2.0 0.3
Wears glasses or contact lenses 0.3 0.3 0.4 0.5 0.6
Ever taken oral contraceptive pill 1.7 1.9 3.8 0.2 1.9
Hearing aid user 3.6 4.1 5.2 -2.3 -1.8
Mother’s age at death 0.1 0.1 0.2 -0.1 0.4
Financial situation satisfaction 0.4 0.5 1.0 -1.0 -0.0
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.0 -1.0 -0.4
Commuting to job workplace: Public transport 2.2 2.6 4.2 -2.0 1.0
Eye problems/disorders: Glaucoma 1.2 1.5 2.8 0.4 1.7
Medication: Blood pressure 0.3 0.6 1.1 -1.0 0.2
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 0.1 0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.1 -0.0 1.1
High cholesterol (Self-reported) 0.5 0.9 1.7 -1.3 0.4
Medication: Bendroflumethiazide 0.5 0.8 1.5 -0.3 1.2
Medication: Paracetamol 1.7 2.6 5.0 0.4 2.2
Medication: Lisinopril 0.8 1.0 1.0 -1.0 -1.0
Medication: Atorvastatin 1.0 1.2 2.3 -1.5 -0.2
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.2 -0.4
Alcohol drinker status: Never 2.1 2.6 3.9 1.1 2.0
Ever smoked 0.1 0.2 0.2 -0.5 0.4
Basal metabolic rate 0.2 1.1 1.9 -1.4 -0.4
Leg fat percentage (left) 0.3 1.1 1.6 -1.3 -0.8
Arm fat-free mass (left) 0.2 0.8 1.4 -1.2 -0.5
Number of operations (self-reported) 0.1 0.1 0.2 0.4 -0.2
Average weekly beer plus cider intake 0.1 0.2 0.3 0.6 0.2
Irritability 0.4 0.7 1.3 -0.2 -1.2
Risk taking 0.4 0.5 0.7 -0.8 -0.6
Ever had prostate specific antigen (PSA) test 1.0 1.2 1.6 -0.9 1.3
Fractured/broken bones in last 5 years 0.3 0.4 0.5 -0.5 0.7
Age started oral contraceptive pill 0.2 0.3 0.3 -0.5 0.6
Diastolic blood pressure, automated reading 0.3 0.9 1.2 -1.1 0.7
Ever depressed for a whole week 0.4 0.4 0.6 0.5 -0.8
Unable to work because of sickness or disability 0.0 0.0 0.0 0.0 0.0
Commuting to job workplace: Cycle 0.9 1.1 2.0 0.4 -1.4
Myopia 0.3 0.4 0.5 -0.6 0.7
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.3 0.5 -0.6
Cholesterol lowering medication 0.5 0.7 1.3 -1.1 0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.3 -0.6 -0.4
Pain experienced in last month 2.2 3.7 7.4 0.3 -2.7
Supplements: Calcium 0.2 0.2 0.4 0.7 0.2
Basal cell carcinoma (self-reported) 0.7 0.9 1.6 -0.3 -1.3
Heart attack/myocardial infarction (self-reported) 2.1 2.7 3.5 -1.9 -1.4
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 1.3 -0.7 1.1
Heart disease (siblings) 0.5 0.6 0.8 -0.9 -0.6
Alcohol drinker status: Previous 0.2 0.2 0.4 0.6 -0.0
Pack years of smoking 0.2 0.4 0.7 0.1 0.8
Impedance of whole body 0.2 0.8 1.5 -0.4 1.2
Leg fat mass (left) 0.4 1.5 2.2 -1.5 -0.9
Arm predicted mass (left) 0.1 0.8 1.3 -1.1 -0.4