Best TWAS P=2.27e-12 · Best GWAS P=3.27e-19 conditioned to 3.95e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM218 | 0.11 | 0.08 | lasso | 4 | 0.06 | 5.5e-08 | -4.8 | -5.2 | 1.6e-07 | -0.08 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AP001007.1 | 0.13 | 0.03 | lasso | 4 | 0.02 | 4.4e-03 | 6.6 | 6.3 | 2.2e-10 | 0.06 | 0.50 | 0.03 | FALSE |
| 3 | GTEx | Brain Cerebellum | FEZ1 | 0.38 | 0.23 | lasso | 8 | 0.21 | 8.3e-07 | -5.1 | 5.2 | 1.8e-07 | 0.03 | 0.61 | 0.02 | FALSE |
| 4 | GTEx | Lung | AP001007.1 | 0.13 | 0.01 | enet | 13 | 0.03 | 3.8e-03 | 4.7 | 5.4 | 6.9e-08 | 0.02 | 0.69 | 0.02 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | FEZ1 | 0.07 | 0.03 | lasso | 5 | 0.04 | 3.1e-04 | -4.2 | -6.5 | 8.3e-11 | 0.01 | 0.35 | 0.02 | TRUE |
| 6 | GTEx | Skin Sun Exposed Lower leg | AP001007.1 | 0.09 | 0.07 | enet | 11 | 0.09 | 8.4e-08 | 4.7 | 6.6 | 3.9e-11 | 0.01 | 0.99 | 0.00 | TRUE |
| 7 | GTEx | Testis | PKNOX2 | 0.21 | 0.01 | enet | 22 | 0.11 | 1.8e-05 | -4.0 | -7.0 | 2.3e-12 | -0.23 | 0.12 | 0.04 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | RP11-680F20.11 | 0.11 | 0.06 | lasso | 6 | 0.08 | 4.1e-10 | -4.9 | -5.2 | 1.8e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC37A2 | 0.04 | 0.04 | lasso | 4 | 0.03 | 3.1e-04 | 4.6 | 5.3 | 1.1e-07 | 0.00 | 0.09 | 0.68 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC37A2 | 0.08 | 0.05 | blup | 73 | 0.06 | 1.1e-07 | 6.6 | 6.8 | 7.4e-12 | 0.10 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | EI24 | 0.32 | 0.06 | enet | 26 | 0.08 | 4.6e-04 | -7.5 | -6.0 | 1.7e-09 | -0.04 | 0.00 | 0.68 | FALSE |