Hub : Genes

PKNOX2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.093 0.039 0.0088 0.023 NA 0.027 NA 0.014 0.0047 NA 2.6e-03 NA 0.0220
2 GTEx Testis 0.206 0.084 0.0097 0.010 NA 0.107 NA 0.051 0.1100 NA 1.8e-05 NA 0.0027

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.3 1.7 -0.9 -1.3
Bipolar Disorder or Schizophrenia 2.4 5.8 8.2 -1.9 -2.9
Depressed Affect (Nagel 2018) 0.5 1.1 1.8 -0.5 -1.4
Depression (Nagel 2018) 0.5 0.7 0.9 -0.9 -0.7
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.0 -0.8 1.0
Neuroticism (Nagel 2018) 1.0 2.4 4.6 0.5 -2.1
Schizophrenia (2018) 2.2 4.6 6.4 -1.7 -2.5
Schizophrenia vs Biploar Disorder 0.9 1.2 2.3 -0.1 -1.5
Worry (Nagel 2018) 0.1 0.1 0.2 0.1 -0.5
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -0.3 0.9
Alzheimer’s Disease (in father) 0.0 0.0 0.0 0.1 0.1
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 -0.5 -0.2
Crohns Disease (2017) 0.2 0.4 0.7 -0.8 0.1
Irritable Bowel Disease (IBD) 0.3 0.7 1.1 -1.0 -0.5
Ulcerative Colitis (UC) 0.4 0.8 1.2 -0.6 -1.1
Major Depression (MDD) 1.3 1.5 3.0 -0.2 -1.7
Reaction Time 0.1 0.3 0.5 0.3 -0.7
Verbal and Numeric Reasoning (VNR) 0.6 1.6 3.1 -1.8 0.2
Breast Cancer 1.0 2.4 4.6 2.1 0.5
Ovarian Cancer 0.1 0.1 0.2 0.1 0.4
Prostate Cancer 3.1 4.3 8.2 -0.6 2.9
Age at First Birth 0.4 0.6 1.2 1.1 -0.0
Bipolar Disorder (2011) 0.6 0.6 1.0 -0.4 -1.0
Body Mass Index (BMI) (2010) 1.6 2.2 4.5 0.2 -2.1
Coronary Artery Disease (CAD) 0.0 0.1 0.1 0.2 0.3
Crohns Disease (2012) 0.2 0.3 0.7 -0.8 -0.1
Mean Putamen Volume 1.9 2.2 2.9 -1.2 1.7
Fasting Glucose 0.2 0.2 0.4 -0.7 -0.2
HbA1C 0.1 0.1 0.2 -0.4 0.0
HDL Cholesterol 0.1 0.1 0.2 0.4 -0.1
LDL Cholesterol 1.8 2.8 5.6 -0.2 2.4
Lupus 0.5 0.8 0.9 0.9 0.9
Neuroticism (2016) 1.5 2.2 3.1 1.2 -1.8
Primary Biliary Cirrhosis 2.3 3.3 4.3 -2.1 -1.6
Rheumatoid Arthritis 0.0 0.0 0.1 0.0 -0.2
Schizophrenia (2014) 1.5 3.2 5.8 -0.8 -2.4
Triglycerides 0.8 1.3 1.9 1.4 -0.8
Type 2 Diabetes (T2D) (2012) 1.8 2.1 3.1 -1.8 -1.0
Ulcerative Colitis 0.1 0.2 0.4 -0.2 -0.6
Blood Eosinophil Count 0.1 0.6 1.1 -1.1 0.1
Blood Platelet Count 0.0 0.4 0.4 -0.6 -0.6
Blood Red Count 0.3 3.2 5.0 -1.2 2.2
Blood White Count 0.1 0.7 1.3 -1.1 -0.0
Heel T-Score 4.6 36.7 49.3 4.9 -7.0
BMI 0.4 2.6 2.7 -1.6 -1.6
Height 0.3 6.5 12.9 -0.4 3.6
Waist Hip Ratio (WHR) 0.3 1.2 1.2 -1.1 -1.1
Systolic Blood Pressure 0.5 2.3 4.0 0.7 -2.0
Smoking Status 0.2 0.6 0.7 0.9 -0.6
Allergy or Eczema 0.2 0.4 0.6 -0.8 0.4
Cardiovascular Disease 0.0 0.1 0.2 0.1 0.4
Hypothyroidism (self reported) 0.1 0.2 0.3 0.5 0.2
Respiratory disease 0.5 1.1 2.1 -1.5 -0.4
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 -0.0 -0.6
Lung FEV1/FVC ratio 0.6 3.0 5.3 -2.3 -0.9
Lung FVC 0.9 4.6 9.0 3.0 0.5
Neuroticism 0.6 1.4 2.7 0.3 -1.6
Chronotype (morning person) 0.1 0.2 0.3 0.2 -0.6
Hair Pigment 0.1 2.3 3.8 2.0 -0.9
Tanning 0.0 0.0 0.1 0.3 0.1
Hand grip strength (left) 0.0 0.1 0.1 0.3 0.4
Number of treatments/medications taken 0.8 1.5 2.3 1.5 0.8
Average weekly spirits intake 4.4 5.4 6.8 -2.6 -2.0
Sensitivity / hurt feelings 5.1 8.7 9.7 2.8 -3.1
Frequency of depressed mood in last 2 weeks 0.0 0.1 0.1 0.0 -0.4
Hearing difficulty/problems: Yes 0.2 0.3 0.5 0.4 -0.7
Relative age of first facial hair 0.2 0.4 0.4 0.5 -0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.5 -1.2 -0.3
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.2 -0.6
Ever had hysterectomy (womb removed) 1.6 1.9 3.0 0.8 -1.7
Systolic blood pressure, automated reading 0.7 1.9 3.8 0.2 -1.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.5 -0.6 0.7
Angina 0.1 0.1 0.3 0.5 -0.1
Medication for hormone replacement therapy 0.4 0.5 0.8 -0.3 0.9
Vitamin and mineral supplements 0.6 0.8 1.2 1.1 0.7
Supplements: Zinc 0.4 0.5 0.9 0.9 0.1
Medication: Co-codamol 0.4 0.5 1.0 -0.1 1.0
Medication: Metformin 0.4 0.5 0.7 -0.6 -0.8
Diabetes (father) 2.3 2.9 3.3 -1.6 -1.8
Diabetes (mother) 2.2 2.8 3.5 -1.4 -1.9
Severe depression (siblings) 0.0 0.1 0.1 -0.3 -0.2
Pack years adult smoking proportion 1.0 1.5 2.0 -1.4 -1.0
Impedance of leg (right) 0.1 0.4 0.8 -0.2 0.9
Leg fat-free mass (left) 0.2 1.2 1.4 -0.9 1.2
Trunk fat percentage 0.9 3.5 4.0 -2.0 1.7
Hand grip strength (right) 0.1 0.2 0.5 0.0 0.7
Townsend deprivation index at recruitment 0.3 0.4 0.7 -0.9 0.1
Current tobacco smoking 0.2 0.3 0.4 0.6 -0.5
Average weekly fortified wine intake 0.7 0.8 0.9 -0.9 -0.9
Maternal smoking around birth 2.8 4.0 5.7 -1.6 -2.4
Fed-up feelings 1.2 2.2 3.9 -2.0 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.1 1.1 -1.1 -1.1
Relative age voice broke 0.2 0.2 0.4 0.2 0.7
Taking other prescription medications 0.1 0.2 0.2 -0.3 0.5
Age when periods started (menarche) 0.8 1.9 2.1 -1.5 1.3
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.5 0.7 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.4 5.4 9.2 1.3 -3.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.4 0.3 0.6
Qualifications: CSEs or equivalent 0.0 0.0 0.0 0.1 0.1
Serious illness, injury or assault to yourself 2.9 3.5 6.9 0.2 -2.6
High blood pressure 0.3 0.8 1.1 0.7 -1.0
Hayfever, allergic rhinitis or eczema 0.3 0.7 0.9 -1.0 0.7
Multivitamins +/- minerals 0.4 0.5 0.5 -0.7 -0.7
Stomach or abdominal pain in last month 1.8 2.2 4.1 0.6 2.0
Supplements: Glucosamine 0.6 0.8 1.4 0.4 -1.2
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.5 0.4 -0.7
Medication: Atenolol 0.7 0.9 1.4 0.5 1.2
Medication: Levothyroxine sodium 0.1 0.2 0.2 0.5 -0.4
Sitting height 1.1 7.9 15.8 -0.4 4.0
Chronic bronchitis/emphysema (father) 1.1 1.3 1.7 1.0 -1.3
High blood pressure (mother) 2.3 3.2 4.3 1.5 -2.1
Body mass index (BMI) 0.1 0.5 0.9 -1.0 -0.3
Impedance of leg (left) 0.2 0.9 1.6 -0.5 1.3
Leg predicted mass (left) 0.2 1.1 1.4 -0.9 1.2
Trunk fat mass 0.9 3.9 4.1 -1.9 2.0
Waist circumference 0.1 0.3 0.5 -0.7 0.3
Number of incorrect matches in round 0.0 0.0 0.0 -0.0 0.1
Past tobacco smoking 1.0 1.9 3.8 -2.0 0.1
Alcohol usually taken with meals 1.5 2.4 3.2 -1.8 1.3
Nervous feelings 0.4 0.7 1.3 -0.3 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.5 -0.7 -0.6
Hearing difficulty/problems with background noise 0.3 0.5 0.9 1.0 -0.1
Hair/balding pattern: Pattern 2 0.8 1.0 1.5 -1.2 0.7
Had menopause 0.6 0.8 1.5 1.2 0.1
Had other major operations 1.1 1.3 1.6 1.0 -1.3
Forced vital capacity (FVC) 0.8 3.2 3.3 1.8 1.8
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 5.1 1.1 -2.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.6 -0.8 -0.7
Qualifications: None of the above 0.4 0.8 1.5 1.2 0.2
Financial difficulties in last 2 years 1.0 1.4 2.2 -0.8 -1.5
Mouth/teeth dental problems 0.3 0.5 1.0 -1.0 -0.0
Heart attack 0.9 1.1 1.6 -1.2 -0.9
Allergy 0.3 0.6 1.1 1.1 0.4
Pain all over the body in last month 0.9 0.9 0.9 -1.0 -1.0
Diabetes (self-reported) 0.2 0.3 0.6 -0.1 -0.8
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 2.1 1.4 1.5
Medication: Ramipril 0.0 0.1 0.1 -0.3 0.2
Medication: Simvastatin 0.9 1.4 2.7 -0.0 1.6
Fluid intelligence score 0.3 0.7 1.3 -1.2 0.1
Illnesses of siblings 0.7 1.0 1.7 -0.4 1.3
Neuroticism score 0.6 1.3 2.5 -0.0 -1.6
Weight 0.4 1.8 2.9 -0.9 1.7
Impedance of arm (right) 0.4 2.0 3.8 -0.4 2.0
Arm fat percentage (right) 0.3 1.4 1.8 -1.3 1.0
Trunk fat-free mass 0.1 0.8 1.6 -0.2 1.2
Hip circumference 0.3 1.4 2.6 -0.3 1.6
Time employed in main current job 0.9 1.0 1.7 1.3 0.6
Alcohol intake versus 10 years previously 0.4 0.6 0.8 -0.7 0.9
Father’s age at death 0.6 0.7 1.3 -0.5 -1.1
Worrier / anxious feelings 0.2 0.4 0.6 -0.4 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 0.8 0.6 -0.9
Falls in the last year 0.9 1.3 1.5 -1.2 -1.0
Hair/balding pattern: Pattern 3 0.3 0.4 0.4 0.6 0.6
Number of live births 2.7 3.8 6.8 -0.9 -2.6
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 3.1 1.1 1.8
Pulse rate 0.1 0.1 0.2 -0.1 -0.5
Happiness 0.3 0.4 0.4 -0.5 -0.7
Noisy workplace 1.4 1.7 2.5 1.6 1.0
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.6 -0.5 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.7 -0.5 -0.8
Mouth/teeth dental problems: Dentures 0.7 1.2 2.2 1.5 -0.3
Asthma 0.2 0.3 0.4 -0.5 -0.6
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 4.8 -2.2 0.9
Medication: Cholesterol lowering 0.1 0.2 0.3 -0.2 0.5
Depression (self-reported) 1.3 1.6 3.2 -0.1 -1.8
Medication: Lansoprazole 0.0 0.0 0.0 0.1 -0.1
Prospective memory result 0.6 0.7 0.9 -0.9 -0.7
Lung cancer (father) 0.1 0.1 0.2 -0.1 0.4
Illnesses of mother 1.7 2.1 3.1 -1.1 1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 3.7 0.6 1.9
Pulse wave Arterial Stiffness index 1.0 1.2 1.7 -1.3 0.9
Impedance of arm (left) 0.4 2.0 3.5 -0.7 1.9
Arm fat mass (right) 0.3 1.3 1.6 -1.2 1.0
Trunk predicted mass 0.1 0.8 1.5 -0.3 1.2
Standing height 1.0 9.8 19.6 -0.2 4.4
Length of working week for main job 0.7 0.8 1.3 -1.2 0.5
Exposure to tobacco smoke at home 0.0 0.1 0.1 -0.3 -0.2
Breastfed as a baby 0.2 0.3 0.4 0.6 0.4
Tense / ‘highly strung’ 1.2 2.0 3.8 -0.5 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 3.0 1.6 -1.7
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 -0.4 -0.8
Birth weight of first child 0.2 0.4 0.8 0.9 -0.1
Peak expiratory flow (PEF) 0.1 0.3 0.6 0.1 0.8
Pulse wave reflection index 0.3 0.3 0.7 -0.0 -0.8
Ever highly irritable/argumentative for 2 days 2.4 2.8 3.6 1.9 -1.4
Loud music exposure frequency 0.6 0.6 1.2 -0.3 1.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 -0.3 -0.6
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.3 -0.7 1.1
Blood clot in the leg (DVT) 0.1 0.2 0.4 0.1 -0.6
Medication: Paracetamol 0.3 0.5 0.6 -0.7 -0.8
Headache pain in last month 0.5 0.9 1.0 1.0 0.9
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 2.0 0.9 -1.4
Glaucoma (self-reported) 0.2 0.2 0.3 -0.3 -0.6
Gout (self-reported) 0.1 0.2 0.4 0.1 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.2 0.4 0.4
Medication: Amlodipine 0.3 0.4 0.7 0.8 0.3
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.3 0.3 -1.5
Birth weight 0.3 0.6 1.2 1.1 0.1
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.6 0.3 -0.8
High blood pressure (siblings) 1.3 1.8 2.7 1.0 -1.6
Forced vital capacity (FVC), Best measure 1.0 3.7 4.2 1.8 2.1
Body fat percentage 0.5 2.0 2.6 -1.6 1.2
Leg fat percentage (right) 0.1 0.5 1.0 -1.0 0.2
Arm fat-free mass (right) 0.2 0.8 1.0 -0.8 1.0
Exposure to tobacco smoke outside home 1.1 1.5 2.9 0.3 -1.7
Comparative body size at age 10 1.3 3.6 6.8 -0.6 -2.6
Number of full brothers 0.7 0.9 1.1 -1.0 -0.9
Worry too long after embarrassment 1.6 2.6 3.5 1.3 -1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 5.8 -1.0 -2.4
Wheeze or whistling in the chest in last year 0.4 0.7 1.5 -1.2 -0.1
Number of children fathered 0.5 0.5 1.0 -0.1 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 2.3 1.5 -1.5
Age at first live birth 0.8 1.4 2.0 0.9 1.4
Pulse wave peak to peak time 0.7 0.9 1.3 1.1 -0.7
Health satisfaction 1.6 2.1 3.5 -1.9 0.8
Shortness of breath walking on level ground 1.2 1.4 2.4 -1.6 0.6
Qualifications: College or University degree 0.3 0.9 1.7 -1.3 0.4
Eye problems/disorders: None of the above 0.3 0.4 0.5 0.7 -0.5
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 0.1 0.0
Emphysema/chronic bronchitis 0.3 0.4 0.4 0.6 -0.6
Medication for pain relief, constipation, heartburn 0.4 0.7 1.1 1.1 -0.5
Neck or shoulder pain in last month 1.4 2.0 4.0 0.1 -2.0
Medication: Blood pressure 0.2 0.4 0.7 0.3 0.8
Angina (self-reported) 0.1 0.2 0.3 0.6 0.2
Migraine (self-reported) 1.2 1.5 2.2 1.5 0.9
Medication: Ibuprofen 1.0 1.2 1.8 -1.3 0.8
Medication: Allopurinol 0.2 0.3 0.6 0.8 -0.1
Medication: Omeprazole 0.3 0.3 0.5 0.7 0.3
Medication: Seretide 50 evohaler 0.6 0.7 1.4 0.2 1.2
Mean time to correctly identify matches 0.2 0.4 0.8 0.9 -0.1
Heart disease (mother) 0.2 0.2 0.4 -0.2 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 1.7 -1.3 -0.8
Whole body fat mass 0.5 2.3 2.3 -1.5 1.5
Leg fat mass (right) 0.3 1.2 2.0 -1.4 0.7
Arm predicted mass (right) 0.1 0.5 0.8 -0.5 0.9
Pulse rate, automated reading 0.8 2.7 4.5 -2.1 -0.9
Alcohol intake frequency. 0.4 1.0 1.5 -1.2 0.7
Comparative height size at age 10 0.3 1.6 3.2 0.1 1.8
Number of full sisters 0.6 0.8 1.6 -0.1 1.3
Suffer from ‘nerves’ 0.1 0.2 0.2 0.5 -0.5
Overall health rating 0.6 1.2 2.3 -1.5 0.4
Chest pain or discomfort 0.5 0.7 1.0 -1.0 0.6
Had major operations 3.1 3.7 6.8 -2.6 -0.7
Age at last live birth 0.2 0.3 0.5 -0.0 0.7
Family relationship satisfaction 0.4 0.4 0.9 -0.9 -0.1
Leg pain on walking 0.3 0.3 0.5 -0.7 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.5 -0.7 -0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.0 1.0 0.8
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 1.4 1.1 1.2
Medication: Aspirin 0.2 0.3 0.6 -0.8 -0.1
Supplements: Vitamin C 0.7 0.8 1.4 -0.4 1.2
Knee pain experienced in last month 1.4 2.2 2.5 -1.6 -1.3
Hypertension (Self-reported) 0.3 0.7 1.0 0.7 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 1.7 1.3 0.9
Illnesses of father: Heart disease 0.7 1.0 2.0 0.1 1.4
Illnesses of siblings: Diabetes 0.5 0.6 1.0 -0.4 -1.0
Smoking status: Previous 0.7 1.0 2.0 1.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.2 -0.4 0.2
Whole body fat-free mass 0.2 0.9 1.4 -0.6 1.2
Leg fat-free mass (right) 0.2 1.2 1.4 -1.0 1.2
Arm fat percentage (left) 0.4 1.5 2.1 -1.4 1.0
Average weekly red wine intake 0.2 0.2 0.3 -0.5 0.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 0.1 -0.9
Mood swings 1.8 3.3 5.7 -1.0 -2.4
Loneliness, isolation 1.5 2.1 4.2 0.1 -2.0
Long-standing illness, disability or infirmity 1.6 2.5 2.8 -1.7 -1.5
Ever had bowel cancer screening 1.1 1.3 2.7 0.1 -1.6
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.5 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.1 -0.2 0.1
Friendships satisfaction 0.1 0.1 0.2 0.4 0.1
Qualifications: nursing, teaching 0.3 0.5 0.9 0.0 -1.0
Commuting to job workplace: Walk 0.4 0.5 0.6 0.6 0.8
Eye problems/disorders: Cataract 1.0 1.2 2.3 -1.5 0.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.4 0.5 0.6
Medication for cholesterol 0.1 0.2 0.4 -0.6 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 2.6 1.3 -1.6
Back pain experienced in last month 0.9 1.4 2.6 -0.3 -1.6
Mineral and other dietary supplements 0.4 0.6 0.9 -0.5 0.9
Breast cancer (self-reported) 0.4 0.5 0.9 0.4 0.9
Asthma (self-reported) 0.2 0.4 0.5 -0.5 -0.7
Osteoporosis (self-reported) 0.1 0.1 0.2 -0.2 0.4
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.4 -0.7
Medication: Aspirin 0.1 0.2 0.2 -0.4 -0.4
Medication: Gliclazide 6.6 7.5 11.5 -1.9 -3.4
Illnesses of father: None of the above (group 1) 0.5 0.6 1.1 1.0 -0.4
Smoking status: Current 0.1 0.2 0.3 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 1.8 1.3 0.9
Whole body water mass 0.2 1.1 1.9 -0.6 1.4
Leg predicted mass (right) 0.2 1.3 1.7 -0.9 1.3
Arm fat mass (left) 0.3 1.3 2.0 -1.4 0.8
Number of self-reported non-cancer illnesses 0.4 0.6 1.2 1.1 0.3
Average weekly champagne plus white wine intake 0.5 0.6 1.1 1.1 0.4
Miserableness 0.4 0.7 1.4 -0.1 -1.2
Guilty feelings 3.7 5.5 10.3 0.9 -3.2
Wears glasses or contact lenses 1.7 1.9 2.5 1.2 1.6
Ever taken oral contraceptive pill 0.0 0.0 0.1 -0.2 -0.1
Hearing aid user 1.1 1.2 2.3 0.4 1.5
Mother’s age at death 1.2 1.5 1.7 1.3 1.1
Financial situation satisfaction 1.7 2.1 2.8 -1.2 1.7
Tinnitus: Yes, now most or all of the time 1.0 1.2 2.3 0.2 1.5
Commuting to job workplace: Public transport 0.5 0.6 1.2 0.2 -1.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.3 0.5 -1.1
Medication: Blood pressure 0.6 1.1 2.0 0.5 -1.4
Pain type(s) experienced in last month: Hip pain 1.5 1.9 3.7 0.2 -1.9
Supplements: Fish oil (including cod liver oil) 1.2 1.6 3.2 0.2 -1.8
High cholesterol (Self-reported) 0.4 0.8 1.5 -0.3 1.2
Medication: Bendroflumethiazide 0.0 0.1 0.1 -0.2 -0.3
Medication: Paracetamol 0.2 0.2 0.3 0.4 -0.6
Medication: Lisinopril 0.2 0.3 0.6 0.7 -0.1
Medication: Atorvastatin 0.2 0.2 0.4 -0.6 -0.3
Illnesses of father: High blood pressure 1.6 2.0 3.6 -0.7 -1.9
Alcohol drinker status: Never 0.3 0.4 0.7 0.1 -0.9
Ever smoked 2.0 3.5 7.0 2.6 -0.3
Basal metabolic rate 0.2 1.2 1.8 -0.8 1.3
Leg fat percentage (left) 0.2 0.8 1.4 -1.2 0.4
Arm fat-free mass (left) 0.1 0.4 0.8 -0.3 0.9
Number of operations (self-reported) 1.4 2.2 3.8 0.7 -2.0
Average weekly beer plus cider intake 0.5 0.8 1.5 0.3 -1.2
Irritability 0.9 1.5 1.8 -1.1 -1.3
Risk taking 0.2 0.3 0.6 0.3 -0.8
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.1 -0.1 1.0
Fractured/broken bones in last 5 years 1.9 2.4 4.0 -0.9 -2.0
Age started oral contraceptive pill 0.1 0.1 0.1 -0.3 -0.2
Diastolic blood pressure, automated reading 0.3 0.9 1.8 0.1 -1.3
Ever depressed for a whole week 1.9 2.3 2.4 -1.5 -1.6
Unable to work because of sickness or disability 1.0 1.3 1.4 -1.2 -1.1
Commuting to job workplace: Cycle 0.1 0.2 0.3 -0.2 -0.5
Myopia 0.1 0.1 0.1 -0.3 0.3
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.4 -0.6 0.6
Cholesterol lowering medication 0.1 0.1 0.2 0.4 0.4
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.8 0.4 0.9
Pain experienced in last month 0.1 0.1 0.1 0.4 0.2
Supplements: Calcium 0.9 1.0 1.1 -1.0 -0.9
Basal cell carcinoma (self-reported) 0.6 0.7 0.8 -0.9 0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 0.8 -0.9 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.2 -0.6
Heart disease (siblings) 0.1 0.1 0.2 -0.2 -0.5
Alcohol drinker status: Previous 0.4 0.4 0.7 -0.8 -0.4
Pack years of smoking 1.4 2.0 2.2 -1.5 -1.3
Impedance of whole body 0.3 1.7 2.6 -0.9 1.6
Leg fat mass (left) 0.3 1.3 2.1 -1.5 0.7
Arm predicted mass (left) 0.1 0.6 0.9 -0.6 1.0