Hub : Genes

FEZ1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1970	0.0490	3.7e-07	0.186	NA	0.176	NA	0.186	1.6e-10	NA	5.5e-10	NA	1.7e-10
2	GTEx	Brain Cerebellum	0.3810	0.1400	1.9e-03	0.230	NA	0.167	NA	0.209	2.1e-07	NA	1.2e-05	NA	8.3e-07
3	GTEx	Skin Sun Exposed Lower leg	0.0650	0.0270	2.9e-03	0.025	NA	0.019	NA	0.040	3.3e-03	NA	9.9e-03	NA	3.1e-04
4	GTEx	Testis	0.2820	0.0680	1.6e-07	0.279	NA	0.259	NA	0.275	8.1e-13	NA	7.2e-12	NA	1.2e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.0384	0.0183	1.1e-02	0.015	0.009	0.006	0.01	0.013	4.0e-03	2.3e-02	4.6e-02	1.8e-02	6.4e-03
6	YFS	Blood	0.0530	0.0133	4.2e-10	0.028	0.043	0.048	0.05	0.042	1.5e-09	5.1e-14	2.4e-15	4.3e-16	9.9e-14
7	TCGA	Lung Squamous Cell Carcinoma	0.0495	0.0336	7.4e-03	-0.002	0.004	0.006	NA	-0.002	5.8e-01	1.1e-01	6.1e-02	NA	9.6e-01
8	TCGA	Thyroid Carcinoma	0.0460	0.0260	3.7e-03	0.020	0.032	0.011	NA	0.018	4.4e-03	4.3e-04	2.5e-02	NA	5.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.1	0.1	0.4	0.3	0.2	-0.4	0.3	0.1	0.6	0.5	0.2
Bipolar Disorder or Schizophrenia	1.2	3.0	6.0	2.2	1.4	-2.5	2.3	2.2	0.3	0.3	1.1
Depressed Affect (Nagel 2018)	0.7	1.5	3.0	1.1	-1.2	-1.2	1.7	1.2	-0.9	-0.9	-1.4
Depression (Nagel 2018)	0.3	0.4	1.0	0.6	-1.0	0.1	0.1	0.3	-1.0	0.1	-0.7
Intelligence (Savage-Jansen 2018)	2.6	8.1	16.7	-2.5	-4.1	3.0	-3.1	-3.4	-1.6	-1.7	-2.4
Neuroticism (Nagel 2018)	0.8	1.8	5.8	1.6	-0.3	-1.4	2.4	1.8	-0.9	0.1	-0.2
Schizophrenia (2018)	2.0	4.2	7.8	2.6	1.7	-2.8	2.7	2.7	-0.2	-0.0	1.2
Schizophrenia vs Biploar Disorder	1.7	2.2	6.3	1.1	2.5	-0.4	1.1	1.0	1.5	1.6	1.8
Worry (Nagel 2018)	0.2	0.4	1.5	0.3	-0.2	0.2	1.2	1.0	-0.4	0.4	0.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	1.2	0.7	-0.5	1.2	1.2	0.2	-0.6	-0.2
Alzheimer’s Disease (in father)	1.5	1.6	3.4	1.3	1.7	-0.5	1.5	1.9	1.0	1.1	0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	4.5	1.8	1.2	-0.7	1.7	2.1	0.4	0.5	0.2
Crohns Disease (2017)	0.8	1.8	5.6	-2.0	1.3	0.5	-0.6	-0.9	2.4	1.4	0.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.9	-2.0	0.2	1.5	-1.2	-1.6	1.5	0.9	-0.7
Ulcerative Colitis (UC)	0.8	1.4	4.9	-1.1	-0.6	2.2	-1.2	-1.7	0.1	0.2	-0.8
Major Depression (MDD)	1.7	2.1	6.5	-0.4	-2.1	-0.6	0.3	-0.3	-0.7	-2.2	-2.5
Reaction Time	1.5	2.9	6.0	2.3	0.8	-1.8	2.3	2.4	-0.5	1.5	0.3
Verbal and Numeric Reasoning (VNR)	1.9	4.5	8.2	-1.9	-2.8	2.4	-2.7	-2.9	-1.2	-1.1	-0.8
Breast Cancer	0.5	1.2	6.2	0.2	0.9	-1.1	-0.1	0.3	-0.6	1.1	2.5
Ovarian Cancer	0.5	0.7	1.8	1.0	-0.4	-0.9	0.4	0.8	-1.3	-1.0	-0.0
Prostate Cancer	1.4	1.9	5.4	-1.1	-1.1	2.3	-1.9	-1.8	0.4	0.5	0.5
Age at First Birth	0.3	0.4	1.2	0.6	0.1	-1.1	0.9	0.7	-0.5	0.6	0.1
Bipolar Disorder (2011)	0.4	0.4	1.9	0.4	-0.4	-0.5	0.3	0.6	-0.4	0.1	1.4
Body Mass Index (BMI) (2010)	1.6	2.1	7.1	-1.1	-1.4	-0.7	-0.6	-1.4	0.9	-1.7	-2.7
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.4	0.1	0.2	0.6	0.4	-0.3	0.8	0.9
Crohns Disease (2012)	0.4	0.7	1.6	-1.2	-0.1	-0.7	-0.0	-0.6	1.2	0.0	-1.2
Mean Putamen Volume	0.0	0.0	0.2	-0.2	-0.2	-0.4	0.1	-0.0	0.0	-0.0	0.1
Fasting Glucose	0.3	0.4	0.9	0.9	0.6	-0.1	0.8	0.8	-0.4	-0.5	0.2
HbA1C	1.1	1.2	2.8	-1.4	-0.7	1.7	-0.9	-1.5	0.3	1.1	-0.3
HDL Cholesterol	0.8	1.3	3.7	1.1	0.0	0.1	1.1	1.9	-1.1	0.4	1.6
LDL Cholesterol	0.3	0.4	0.8	-0.6	-0.2	-0.9	-0.4	-0.5	0.9	0.3	-0.8
Lupus	0.1	0.1	0.3	-0.2	0.5	0.2	-0.1	0.1	-0.3	-0.2	0.6
Neuroticism (2016)	2.0	3.0	7.7	1.6	1.0	-2.3	2.8	2.0	0.2	1.2	-1.2
Primary Biliary Cirrhosis	1.6	2.3	9.6	1.2	-0.5	-1.8	1.3	0.2	0.6	-1.3	-3.1
Rheumatoid Arthritis	1.0	1.4	4.3	-0.1	1.9	-0.3	0.2	-0.1	2.1	1.9	-0.1
Schizophrenia (2014)	2.6	5.7	9.6	3.1	2.3	-2.6	3.0	3.1	-0.2	1.3	2.1
Triglycerides	2.0	3.3	6.3	-2.0	-1.0	2.1	-2.4	-2.5	1.1	-0.7	-1.9
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.1	1.1	0.9	-1.3	1.8	1.1	1.6	-1.2	-0.9
Ulcerative Colitis	0.3	0.5	2.9	0.4	-0.5	-0.1	-0.0	-0.5	-0.2	-0.2	-1.7
Blood Eosinophil Count	0.1	0.9	2.1	1.4	-0.3	0.2	0.8	1.1	-1.2	0.6	1.2
Blood Platelet Count	0.8	8.8	27.9	-1.5	-5.3	1.3	-2.4	-2.5	-3.5	-3.3	-1.8
Blood Red Count	0.2	1.8	5.4	0.5	-2.3	2.1	-0.2	0.4	-1.9	-0.5	0.1
Blood White Count	0.4	3.3	9.7	-0.6	-2.7	3.1	-0.9	-0.2	-2.8	-0.5	0.2
Heel T-Score	2.0	15.8	42.1	3.1	5.2	-6.5	4.6	3.8	3.3	0.9	-0.4
BMI	0.5	3.2	11.1	0.3	-2.2	-1.7	0.6	-0.5	0.1	-2.4	-3.3
Height	0.2	3.4	16.6	-2.0	-0.1	4.1	-1.3	-1.3	0.9	-1.2	1.0
Waist Hip Ratio (WHR)	0.5	2.5	8.4	1.4	-2.1	-1.2	0.5	0.8	-2.9	-1.6	0.4
Systolic Blood Pressure	0.2	1.2	4.6	-0.4	1.0	2.1	-0.9	0.3	1.3	0.5	0.8
Smoking Status	1.1	2.6	5.2	1.6	2.3	-1.5	2.0	2.1	0.6	1.3	0.5
Allergy or Eczema	0.2	0.6	2.0	0.8	0.6	-0.7	1.4	1.1	-0.1	-0.2	-0.6
Cardiovascular Disease	0.2	0.6	1.6	0.4	-1.2	0.6	0.5	0.1	-0.3	-1.2	-1.1
Hypothyroidism (self reported)	0.6	1.3	2.6	-1.2	-1.6	0.1	-1.2	-1.5	-1.6	0.6	0.2
Respiratory disease	0.5	1.1	2.6	0.9	1.6	-0.5	1.4	0.7	1.6	-0.4	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.2	4.6	-0.8	-0.1	-1.6	0.0	-0.3	0.9	-0.8	-2.1
Lung FEV1/FVC ratio	2.3	11.6	34.4	3.7	-2.0	-5.9	3.8	2.9	-1.4	-2.6	-3.1
Lung FVC	0.9	4.7	12.1	-1.8	-2.1	3.5	-1.8	-1.4	0.2	-3.5	-0.7
Neuroticism	0.2	0.5	1.6	0.6	-0.6	-0.3	1.3	0.7	-0.4	-0.4	-1.0
Chronotype (morning person)	0.9	2.2	4.2	-1.8	0.4	1.9	-2.0	-1.8	1.4	0.2	1.1
Hair Pigment	0.0	0.8	2.4	-1.0	-0.4	1.5	-0.7	-0.9	-0.3	1.3	0.3
Tanning	0.0	0.5	1.3	1.0	0.3	0.3	1.1	0.8	-0.1	-1.1	0.2
Hand grip strength (left)	0.6	1.6	4.3	-0.3	2.1	1.9	-0.4	-0.5	1.1	0.7	1.7
Number of treatments/medications taken	0.4	0.7	2.5	0.7	-0.7	-0.2	0.8	1.1	-1.6	0.6	0.1
Average weekly spirits intake	1.2	1.5	5.0	0.2	-0.9	-1.5	0.9	0.9	0.8	-2.2	-1.4
Sensitivity / hurt feelings	0.4	0.7	1.7	0.5	1.3	-0.4	1.0	0.5	-0.3	1.2	1.0
Frequency of depressed mood in last 2 weeks	0.8	1.2	4.2	0.9	0.0	-1.3	1.3	0.9	-0.1	0.5	-2.0
Hearing difficulty/problems: Yes	2.7	4.1	13.2	1.9	0.9	-3.6	2.6	2.4	0.4	1.2	0.9
Relative age of first facial hair	0.9	1.9	5.5	-1.2	-0.8	2.4	-1.5	-1.2	-1.3	1.2	0.8
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	6.6	2.6	1.0	-2.4	2.4	2.3	0.1	0.9	0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.9	0.0	0.0	-0.5	0.1	-0.2	0.5	-0.4	-1.0
Ever had hysterectomy (womb removed)	1.1	1.3	3.9	-1.3	-0.1	0.4	-1.6	-2.0	0.7	0.2	-1.1
Systolic blood pressure, automated reading	0.4	1.3	4.9	-0.8	0.7	2.2	-1.5	-0.7	1.2	-0.2	0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.1	-0.8	0.5	-1.1	-0.2	0.0	0.9	0.9	0.1
Angina	2.2	2.8	9.3	-0.4	-2.7	-0.7	-0.5	-0.5	-1.6	-1.5	-3.1
Medication for hormone replacement therapy	0.3	0.3	0.7	0.4	-0.4	-0.8	0.6	0.8	0.1	-0.7	0.3
Vitamin and mineral supplements	0.9	1.3	4.4	1.1	-0.3	-0.1	1.4	1.4	-0.5	-2.1	-0.3
Supplements: Zinc	1.4	1.5	4.0	-1.6	1.0	-0.5	-0.8	-1.4	2.0	0.2	-1.2
Medication: Co-codamol	2.2	2.5	6.2	2.5	0.4	-0.7	2.0	2.2	-1.2	-0.2	1.8
Medication: Metformin	1.7	2.5	5.7	-0.2	-2.1	-2.4	0.0	-0.1	-0.7	-2.1	-2.2
Diabetes (father)	1.8	2.2	5.2	2.3	-0.0	-1.7	2.3	1.9	-0.5	-0.6	-0.5
Diabetes (mother)	1.2	1.5	4.0	-0.1	-1.7	0.6	-0.3	-0.3	-0.9	-1.9	-2.0
Severe depression (siblings)	0.3	0.3	0.9	0.2	-0.0	-0.7	1.0	0.7	0.5	-0.5	-0.5
Pack years adult smoking proportion	1.5	2.2	6.6	-1.9	1.2	-0.2	-1.5	-1.6	0.8	2.6	0.8
Impedance of leg (right)	0.4	2.0	5.9	1.5	-0.5	0.0	1.1	1.8	-2.4	0.3	1.7
Leg fat-free mass (left)	0.3	1.5	3.5	-1.5	0.0	0.7	-0.9	-1.7	1.9	-0.9	-1.1
Trunk fat percentage	0.3	1.1	3.2	-1.8	-0.9	0.2	-1.5	-1.6	0.1	-0.2	-0.5
Hand grip strength (right)	0.5	1.2	5.0	-0.8	0.3	2.2	-1.2	-1.4	0.3	-0.1	0.8
Townsend deprivation index at recruitment	1.6	2.2	5.1	1.3	1.6	-2.2	1.6	1.0	0.6	2.0	-0.7
Current tobacco smoking	1.3	2.1	5.4	0.5	1.3	-0.3	0.9	1.5	-1.1	2.3	2.1
Average weekly fortified wine intake	1.4	1.7	5.6	0.7	0.2	-2.4	1.1	1.2	0.6	-1.1	-1.7
Maternal smoking around birth	1.4	2.0	4.8	1.7	2.2	-1.4	2.1	1.1	0.8	0.0	-0.3
Fed-up feelings	2.2	4.0	8.6	2.2	-1.1	-2.9	2.9	1.8	-1.4	-0.5	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	1.1	-0.4	-0.2	0.3	0.5	-0.7	1.3	0.6
Relative age voice broke	1.7	2.7	6.0	-2.4	-1.5	1.1	-2.1	-2.4	-1.1	-0.3	-0.4
Taking other prescription medications	0.5	0.8	1.8	-0.7	-1.4	0.9	-0.7	-0.6	-1.2	0.2	-0.8
Age when periods started (menarche)	1.1	2.7	10.0	-0.7	1.4	1.8	-1.2	-0.5	-0.0	2.0	3.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.6	-1.2	-0.6	-0.6	-1.0	-1.3	-0.2	-0.8	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	8.5	-0.6	0.2	-2.1	-0.1	-0.4	2.9	-1.8	-1.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.6	0.2	-0.5	0.7	-0.1	-0.3	-0.8	0.7	0.1
Qualifications: CSEs or equivalent	0.5	0.7	2.3	-0.3	1.3	1.5	0.1	0.3	1.2	0.3	-0.0
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.2	-0.3	-0.4	0.2	0.1	-0.1	0.5	-0.1
High blood pressure	0.3	0.8	2.6	-0.2	-1.5	0.5	-0.1	-0.5	-0.1	-1.0	-1.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.4	0.0	0.1	0.7	0.4	-0.0	-0.7	-0.8
Multivitamins +/- minerals	0.9	1.1	4.0	-0.8	0.7	-0.1	-1.1	-1.0	0.7	2.0	1.0
Stomach or abdominal pain in last month	0.6	0.7	1.4	0.6	-0.9	-1.1	0.9	1.0	-1.2	-0.1	0.1
Supplements: Glucosamine	0.7	1.0	2.0	-1.4	-0.8	1.1	-1.1	-1.3	0.4	-0.8	-0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	-0.9	-0.4	0.6	-0.8	-1.2	0.1	-0.1	-0.3
Medication: Atenolol	0.3	0.4	0.9	0.5	-0.8	-0.9	0.8	0.5	-0.7	0.2	-0.3
Medication: Levothyroxine sodium	0.7	1.2	4.3	-0.8	-2.1	-0.3	-0.8	-1.2	-1.3	-0.6	-0.4
Sitting height	1.3	9.0	34.3	-3.6	0.4	5.9	-3.2	-2.9	1.7	-0.0	1.6
Chronic bronchitis/emphysema (father)	0.3	0.4	1.5	-0.1	-0.5	-0.3	-0.7	-0.6	-0.2	0.8	-1.2
High blood pressure (mother)	0.2	0.2	0.8	0.4	0.9	-0.1	0.3	0.3	0.7	-0.3	-0.3
Body mass index (BMI)	0.5	2.3	5.5	-1.7	-1.1	-1.0	-1.2	-1.9	1.3	-1.0	-2.4
Impedance of leg (left)	0.5	2.7	7.2	1.7	-0.4	-0.0	1.2	2.1	-2.7	0.8	2.2
Leg predicted mass (left)	0.3	1.5	3.4	-1.5	-0.1	0.7	-0.8	-1.6	1.8	-1.0	-1.2
Trunk fat mass	0.3	1.3	3.0	-1.7	-0.8	-0.1	-1.3	-1.7	0.6	-0.8	-1.1
Waist circumference	0.4	1.6	3.6	-1.1	-1.7	-1.0	-0.9	-1.1	-0.5	-1.2	-1.9
Number of incorrect matches in round	0.3	0.4	1.7	0.3	1.3	-0.3	0.5	0.1	0.8	0.4	0.7
Past tobacco smoking	0.3	0.6	2.0	0.5	-0.9	-0.5	-0.1	-0.1	-1.4	0.5	1.1
Alcohol usually taken with meals	2.1	3.4	6.1	-1.8	-2.2	2.1	-1.5	-1.9	-1.5	-2.5	-0.2
Nervous feelings	1.0	1.9	5.3	0.9	1.4	0.4	0.8	1.3	-0.3	2.2	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.4	1.5	-0.7	-1.1	1.4	1.4	-1.2	0.7	0.1
Hearing difficulty/problems with background noise	3.9	6.2	13.2	3.1	1.6	-2.5	3.6	3.5	-0.3	1.3	2.0
Hair/balding pattern: Pattern 2	0.5	0.7	1.6	1.3	0.5	-0.7	1.1	1.2	0.3	0.0	-0.3
Had menopause	0.2	0.2	0.8	-0.7	0.2	-0.4	-0.2	-0.4	0.9	0.4	-0.0
Had other major operations	1.5	1.9	6.2	0.1	-2.0	-0.2	0.3	-0.1	-0.9	-2.5	-1.9
Forced vital capacity (FVC)	0.7	2.5	11.0	-0.6	-1.2	3.3	-0.7	-0.4	-0.3	-2.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	7.4	-0.7	0.4	-2.1	0.1	-0.6	2.7	-0.8	-1.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	-1.1	0.2	0.5	-0.4	-0.8	0.3	0.3	-1.2
Qualifications: None of the above	0.1	0.3	0.9	0.7	-0.9	0.3	0.5	0.6	-0.4	0.2	-0.2
Financial difficulties in last 2 years	0.9	1.3	4.3	-0.0	-1.4	0.6	0.1	0.1	-1.1	-2.1	-1.5
Mouth/teeth dental problems	0.5	0.8	2.0	-0.5	1.4	-0.1	-0.5	0.3	0.2	1.3	1.4
Heart attack	0.1	0.1	0.7	-0.4	-0.2	-0.2	-0.0	0.0	-0.0	-0.1	-0.8
Allergy	0.1	0.3	0.9	-0.5	-0.2	-0.0	-0.9	-0.5	-0.6	1.0	0.0
Pain all over the body in last month	0.7	0.7	2.0	1.4	-0.1	-0.6	1.2	0.9	-0.5	-0.3	0.8
Diabetes (self-reported)	1.1	1.7	7.4	-0.6	-1.3	-2.7	-0.0	0.1	-0.5	-0.7	-1.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.2	-0.6	1.0	0.2	-0.1	-0.4	-0.6	-0.2
Medication: Ramipril	1.8	2.3	5.0	-1.5	-2.2	1.5	-1.7	-1.6	-0.9	-1.5	-0.5
Medication: Simvastatin	3.3	4.8	10.4	2.9	0.4	-2.9	3.2	3.2	-0.6	-0.1	0.8
Fluid intelligence score	2.1	4.3	8.4	-1.7	-2.9	2.2	-2.4	-2.5	-1.8	-1.6	-0.6
Illnesses of siblings	0.8	1.2	4.0	1.4	-0.2	-0.5	1.0	0.8	-2.0	0.6	1.0
Neuroticism score	0.5	1.1	4.4	1.1	0.5	-0.9	2.1	1.4	0.2	0.3	-0.7
Weight	0.4	1.9	3.8	-1.9	-0.8	0.1	-1.2	-1.9	1.4	-1.1	-1.6
Impedance of arm (right)	0.5	2.2	5.5	0.2	1.0	1.8	-0.0	0.6	-1.7	2.2	2.3
Arm fat percentage (right)	0.3	1.2	2.6	-1.5	-0.9	-0.3	-1.1	-1.5	0.5	-0.3	-1.6
Trunk fat-free mass	0.2	1.2	2.7	-0.9	-0.7	0.3	-0.4	-1.1	1.5	-1.6	-1.4
Hip circumference	0.4	1.6	3.4	-1.8	-0.3	0.1	-1.0	-1.6	1.6	-0.6	-1.8
Time employed in main current job	0.4	0.5	1.3	-0.1	1.0	-0.6	0.0	-0.1	0.8	0.7	-1.1
Alcohol intake versus 10 years previously	0.8	1.1	4.9	-0.1	-2.2	0.9	-0.8	-0.9	-1.1	-0.7	-0.4
Father’s age at death	0.1	0.1	0.5	-0.1	-0.2	-0.7	-0.4	-0.0	-0.4	-0.4	0.3
Worrier / anxious feelings	0.3	0.5	2.9	-0.4	0.4	1.7	0.6	0.0	-0.1	0.3	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.2	1.8	-0.6	-1.0	1.5	1.1	-1.4	0.3	0.8
Falls in the last year	0.9	1.2	3.4	-0.3	-0.9	1.5	-0.8	-0.4	-1.3	0.8	1.9
Hair/balding pattern: Pattern 3	2.0	3.0	7.6	-2.8	0.1	0.6	-2.1	-2.5	1.7	-0.0	-1.7
Number of live births	0.2	0.3	0.6	0.5	0.1	-0.2	0.8	0.7	-0.7	-0.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	7.5	0.7	-1.4	1.5	0.6	0.6	-0.6	-2.7	-0.0
Pulse rate	0.2	0.4	2.4	-0.2	0.2	1.6	-0.2	0.3	0.6	-0.4	0.2
Happiness	0.1	0.1	0.2	0.4	-0.5	-0.2	0.1	0.3	-0.4	0.5	-0.2
Noisy workplace	1.1	1.4	4.1	0.3	1.4	-2.0	0.8	1.0	0.5	1.7	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.4	0.7	0.7	-0.4	1.2	0.7	-0.8	0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.5	1.6	-1.3	-0.8	1.4	1.0	-1.2	-1.4	-1.0
Mouth/teeth dental problems: Dentures	1.3	2.1	4.4	-1.7	-1.2	1.9	-1.9	-2.1	-0.1	-0.2	-0.9
Asthma	0.2	0.3	1.3	0.2	0.5	-0.0	0.8	0.2	1.1	-0.7	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	0.9	0.3	0.4	0.8	0.5	-0.6	-0.8	-0.0
Medication: Cholesterol lowering	1.8	2.9	7.6	1.6	1.3	-2.8	2.1	2.0	0.7	1.4	0.1
Depression (self-reported)	0.5	0.7	3.0	0.1	-1.3	-0.1	0.4	0.1	-0.6	0.0	-1.7
Medication: Lansoprazole	0.7	0.8	2.3	1.3	0.2	0.6	1.1	1.5	-0.3	-0.0	0.9
Prospective memory result	2.9	3.6	5.4	1.8	2.3	-1.8	2.1	2.1	1.0	2.1	1.6
Lung cancer (father)	1.1	1.3	2.1	-1.2	-1.4	0.7	-1.4	-1.1	-0.8	-1.3	-0.8
Illnesses of mother	0.5	0.6	2.5	0.4	-0.3	-0.9	0.3	0.4	-0.2	1.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	7.7	0.8	-1.5	0.9	0.7	0.5	-0.5	-2.8	-0.2
Pulse wave Arterial Stiffness index	1.4	1.7	4.5	2.1	0.2	0.2	1.5	1.9	-1.0	0.0	1.4
Impedance of arm (left)	0.4	2.0	4.8	-0.4	0.5	2.0	-0.6	-0.1	-1.7	1.9	2.2
Arm fat mass (right)	0.4	1.7	3.2	-1.7	-0.9	-0.2	-1.2	-1.8	1.2	-1.0	-1.8
Trunk predicted mass	0.2	1.3	3.0	-0.9	-0.8	0.4	-0.4	-1.1	1.4	-1.7	-1.4
Standing height	0.1	1.2	6.1	-0.7	0.5	2.5	-0.2	-0.3	0.5	-0.3	1.5
Length of working week for main job	0.8	0.9	2.3	1.2	-1.3	-0.5	0.7	0.7	-1.5	-0.9	-0.0
Exposure to tobacco smoke at home	0.6	0.6	1.4	1.2	0.8	-0.6	0.4	0.2	-0.4	1.2	0.9
Breastfed as a baby	1.1	1.4	2.3	-0.8	-1.5	1.0	-1.1	-1.4	-1.4	0.3	-1.4
Tense / ‘highly strung’	0.8	1.3	2.5	0.3	1.5	-0.9	1.4	1.4	1.6	0.9	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.0	0.5	-0.9	-1.4	1.1	0.9	-0.9	-0.4	-1.1
Hair/balding pattern: Pattern 4	1.3	3.1	7.1	1.8	-1.7	-1.7	2.0	1.5	-1.0	-2.7	-1.1
Birth weight of first child	0.4	0.8	2.1	0.7	1.5	-0.7	0.4	0.7	0.2	1.1	0.9
Peak expiratory flow (PEF)	0.5	1.3	7.0	0.2	-0.7	-0.4	0.5	0.0	1.0	-2.6	-1.1
Pulse wave reflection index	4.0	4.9	9.5	3.1	1.4	-1.5	2.4	2.8	-1.7	1.7	2.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.9	1.0	0.6	-1.4	2.0	1.4	1.0	-1.0	-1.8
Loud music exposure frequency	0.7	0.7	1.4	-1.2	1.0	0.9	-0.5	-1.0	1.0	0.5	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.7	-1.6	0.6	-0.1	-1.0	-1.2	1.0	0.1	-0.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.4	1.8	-1.4	-1.2	1.7	1.3	-0.9	-1.2	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.5	0.3	-0.4	0.4	-0.1	0.4	-0.2	-0.5
Medication: Paracetamol	0.1	0.2	1.0	0.2	0.2	-0.2	0.4	0.1	-1.0	0.1	0.0
Headache pain in last month	1.2	2.1	4.5	1.9	0.8	-0.9	2.0	2.1	-1.4	0.7	0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	5.0	-0.6	-0.6	2.2	-1.2	-1.2	-0.8	-0.7	0.7
Glaucoma (self-reported)	0.3	0.4	1.8	0.2	-1.3	-0.4	-0.5	-0.4	-0.6	-0.6	-0.4
Gout (self-reported)	0.7	0.9	1.9	-1.0	-1.1	0.4	-0.7	-1.4	0.6	-1.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.9	-0.5	-1.3	-0.1	-0.4	-0.7	-1.4	0.3	-0.0
Medication: Amlodipine	0.6	0.8	2.5	0.8	0.2	-0.4	1.2	1.6	-0.4	0.1	1.1
Medication: Ventolin 100micrograms inhaler	1.8	2.3	5.2	2.3	1.1	-0.2	2.3	2.0	-0.7	0.4	1.4
Birth weight	0.4	0.8	2.2	-1.1	-0.1	1.0	-1.2	-1.5	0.3	0.5	0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	5.2	-0.0	2.2	-0.2	0.5	0.0	2.3	-0.4	0.3
High blood pressure (siblings)	0.1	0.1	0.3	-0.3	-0.3	0.4	-0.2	0.4	0.6	-0.3	-0.1
Forced vital capacity (FVC), Best measure	0.4	1.6	5.7	-0.1	-1.1	2.4	-0.2	-0.1	-0.3	-2.4	0.5
Body fat percentage	0.2	0.8	1.6	-1.3	-1.0	-0.3	-1.0	-1.2	-0.0	-0.4	-1.0
Leg fat percentage (right)	0.4	1.4	4.3	-0.7	-1.4	-1.4	-0.3	-0.7	0.1	-1.4	-2.1
Arm fat-free mass (right)	0.2	1.1	3.0	-0.9	-0.7	0.1	-0.5	-1.2	1.3	-1.7	-1.1
Exposure to tobacco smoke outside home	1.4	1.8	4.7	1.8	0.2	-2.2	1.4	1.5	-1.1	0.2	1.1
Comparative body size at age 10	0.3	0.9	2.8	0.4	-0.6	-1.7	0.7	0.1	0.5	-0.5	-1.7
Number of full brothers	0.6	0.8	2.3	0.6	0.2	-0.9	0.3	0.9	0.0	1.4	1.5
Worry too long after embarrassment	0.2	0.3	0.7	-0.0	0.4	-0.4	0.6	0.3	0.4	0.6	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.0	1.1	-1.5	0.1	1.0	0.8	-1.7	-0.9	-0.6
Wheeze or whistling in the chest in last year	2.0	3.5	6.7	2.2	1.3	-0.5	2.1	2.6	-1.2	1.5	2.5
Number of children fathered	0.6	0.6	3.0	0.5	-0.5	1.7	-0.4	-0.1	-1.1	0.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.9	1.4	0.4	-0.3	1.1	1.0	-0.0	0.2	0.3
Age at first live birth	0.4	0.7	2.6	-0.3	-0.1	0.3	-0.5	0.1	-1.6	1.1	1.2
Pulse wave peak to peak time	1.8	2.1	5.4	-2.3	-0.4	0.0	-1.6	-2.2	1.1	-0.2	-1.6
Health satisfaction	0.5	0.7	1.8	1.0	-1.3	-0.5	0.8	0.5	-0.3	-1.2	-0.5
Shortness of breath walking on level ground	1.0	1.2	3.4	1.3	-0.2	-1.6	1.9	1.2	-0.1	-0.8	-0.1
Qualifications: College or University degree	0.8	2.6	9.2	1.6	-0.0	-3.0	2.0	1.7	-0.6	-0.1	-1.4
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.8	0.5	0.1	0.6	0.5	0.6	-0.3	0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.4	1.2	1.3	-0.8	1.8	1.2	0.6	1.0	-0.8
Emphysema/chronic bronchitis	2.4	2.7	9.5	2.0	0.3	-3.1	2.1	1.8	-0.2	0.2	-0.0
Medication for pain relief, constipation, heartburn	0.3	0.4	0.9	-0.9	-0.2	0.5	-1.0	-0.3	0.9	0.7	0.5
Neck or shoulder pain in last month	1.3	1.9	4.2	1.7	-0.8	-1.0	1.9	1.2	-0.8	-2.0	-0.7
Medication: Blood pressure	0.1	0.2	0.5	-0.4	-0.7	-0.7	-0.3	-0.1	0.1	-0.2	-0.7
Angina (self-reported)	2.0	2.7	8.6	-0.5	-2.7	-0.5	-0.5	-0.5	-1.6	-1.3	-2.9
Migraine (self-reported)	0.2	0.2	1.1	-0.5	1.0	0.1	0.1	0.2	0.5	0.1	0.5
Medication: Ibuprofen	0.2	0.3	0.7	-0.0	0.1	0.8	0.0	-0.0	-0.7	-0.6	0.8
Medication: Allopurinol	0.2	0.3	1.1	-0.7	-0.3	0.3	-0.5	-1.0	0.0	-0.0	0.2
Medication: Omeprazole	0.5	0.6	1.0	-0.9	-0.6	0.7	-0.9	-1.0	-0.6	-0.4	0.7
Medication: Seretide 50 evohaler	1.8	2.0	4.6	-0.3	1.9	2.1	-0.5	-0.1	0.2	1.9	1.9
Mean time to correctly identify matches	1.2	2.2	5.5	1.7	0.2	-1.5	1.6	2.3	-1.2	1.5	1.0
Heart disease (mother)	0.4	0.5	1.7	-0.4	0.9	0.4	-0.2	-0.0	0.1	0.9	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.0	1.4	-0.1	0.9	0.7	1.3	-1.2	-1.7	0.7
Whole body fat mass	0.3	1.2	2.4	-1.5	-0.9	-0.3	-1.1	-1.5	0.7	-0.8	-1.4
Leg fat mass (right)	0.3	1.2	3.3	-0.9	-0.9	-1.2	-0.4	-1.0	0.9	-1.2	-1.8
Arm predicted mass (right)	0.2	1.2	3.6	-0.8	-0.7	-0.3	-0.3	-1.0	1.4	-1.9	-1.3
Pulse rate, automated reading	0.2	0.6	1.0	-0.6	-0.8	1.0	-1.0	-0.7	-0.5	-0.8	-0.9
Alcohol intake frequency.	0.2	0.5	1.5	0.7	-1.2	-0.6	0.2	0.5	-1.0	-0.4	-0.1
Comparative height size at age 10	0.2	1.1	2.1	1.3	1.4	-0.5	1.4	1.1	1.0	-0.2	0.6
Number of full sisters	0.8	0.9	2.2	-0.7	-1.5	1.0	-1.1	-1.1	-1.0	-0.6	0.2
Suffer from ‘nerves’	0.5	0.7	1.7	0.7	0.2	-0.4	1.3	0.9	-0.6	1.3	-0.8
Overall health rating	1.2	2.6	7.4	1.0	-2.7	-1.5	1.5	1.2	-2.0	-1.3	-0.8
Chest pain or discomfort	1.2	1.7	4.7	1.2	-0.9	-2.2	1.5	0.9	-1.5	-0.5	-1.1
Had major operations	0.3	0.4	1.0	-0.3	-1.0	-0.9	-0.5	-0.3	-0.8	0.0	-0.1
Age at last live birth	1.0	1.5	5.4	0.2	0.1	-0.1	-0.1	0.6	-1.5	2.3	1.9
Family relationship satisfaction	0.7	0.9	2.7	0.7	0.3	-1.6	1.2	1.2	0.6	-0.4	0.8
Leg pain on walking	1.2	1.5	3.3	0.6	-0.7	-1.8	1.5	1.4	0.5	-1.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.6	0.7	0.2	0.6	0.3	0.5	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.9	-1.3	-0.3	2.0	-0.9	-0.9	0.4	-0.8	-0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	4.3	0.1	1.7	0.4	-0.3	0.0	0.1	1.4	2.1
Medication: Aspirin	0.6	0.8	1.9	0.6	-1.4	-0.5	0.6	0.6	-0.8	-1.4	-1.0
Supplements: Vitamin C	0.5	0.6	1.3	-0.4	-1.1	-0.7	-1.0	-0.8	-1.1	0.7	-0.2
Knee pain experienced in last month	1.0	1.5	3.1	0.7	-0.9	-1.5	1.4	0.6	0.4	-1.8	-1.7
Hypertension (Self-reported)	0.3	0.8	2.3	-0.5	-1.4	0.6	-0.3	-0.7	-0.1	-0.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.2	-1.2	1.5	1.2	-1.2	-1.0	0.9	1.1	1.3
Illnesses of father: Heart disease	0.5	0.7	1.7	0.7	-0.2	-0.8	1.3	1.1	-0.4	-0.7	-0.8
Illnesses of siblings: Diabetes	0.9	1.1	2.9	-0.7	1.0	-0.4	0.2	-0.0	1.5	-1.5	-1.7
Smoking status: Previous	0.5	0.8	2.4	-0.3	-0.1	0.5	-0.1	-0.2	1.2	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.6	1.0	1.0	-0.4	1.0	1.3	0.6	0.4	0.4
Whole body fat-free mass	0.2	1.4	2.8	-1.2	-0.5	0.5	-0.7	-1.4	1.7	-1.4	-1.3
Leg fat-free mass (right)	0.2	1.2	3.1	-1.4	0.1	0.7	-0.8	-1.5	1.8	-0.7	-0.9
Arm fat percentage (left)	0.4	1.7	3.4	-1.7	-1.1	-0.4	-1.3	-1.9	0.6	-0.5	-1.9
Average weekly red wine intake	0.6	0.9	2.4	-1.1	0.4	-0.5	-0.4	-0.9	1.5	-1.3	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.0	-0.9	0.5	1.7	-0.9	-1.1	1.3	-0.3	-1.6
Mood swings	0.5	0.9	2.6	1.1	-0.1	-1.0	1.6	1.1	-0.4	-0.3	-1.2
Loneliness, isolation	1.9	2.6	6.4	1.1	-0.6	-2.5	2.0	1.6	0.4	-0.6	-2.4
Long-standing illness, disability or infirmity	0.9	1.4	3.3	1.8	0.4	-1.2	1.7	1.8	-0.0	-0.0	0.3
Ever had bowel cancer screening	1.2	1.4	2.4	0.9	-0.6	-1.6	1.5	1.1	-0.7	-1.4	-1.3
Diabetes diagnosed by doctor	0.8	1.4	6.1	-0.6	-1.1	-2.5	-0.1	0.1	-0.4	-0.8	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	7.0	1.4	-0.1	-2.6	2.4	1.9	-0.1	-0.1	-1.2
Friendships satisfaction	3.1	3.8	6.4	2.1	1.7	-1.5	2.3	2.5	-0.7	1.7	2.4
Qualifications: nursing, teaching	1.1	1.7	3.9	1.5	-0.4	-2.0	1.4	0.7	-0.2	-1.9	-1.0
Commuting to job workplace: Walk	1.0	1.1	2.8	0.9	-0.4	-1.7	1.6	1.2	-0.6	-0.7	0.2
Eye problems/disorders: Cataract	1.0	1.2	3.3	-1.8	-0.4	-0.1	-1.4	-1.7	-0.7	0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.2	2.3	-0.7	-1.6	2.2	1.4	-0.9	-1.7	-1.1
Medication for cholesterol	0.4	0.6	2.1	0.3	1.0	0.1	0.0	-0.2	0.6	1.0	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	3.7	0.5	-1.9	1.0	-0.3	-0.5	-1.8	-0.5	0.1
Back pain experienced in last month	1.5	2.2	4.2	1.7	-1.4	-1.1	2.1	1.5	-1.0	-1.3	-1.5
Mineral and other dietary supplements	0.8	1.1	2.6	1.4	1.2	-0.2	1.3	1.6	-0.5	0.3	0.9
Breast cancer (self-reported)	0.6	0.7	3.8	0.6	-0.9	-1.9	0.1	-0.1	-0.4	0.6	0.4
Asthma (self-reported)	0.2	0.3	1.3	0.1	0.3	0.1	0.6	-0.2	1.1	-0.9	-0.0
Osteoporosis (self-reported)	0.6	0.8	2.6	0.3	0.9	-1.0	0.3	0.6	0.8	1.6	-0.6
Osteoarthritis (self-reported)	0.7	0.9	3.6	0.8	0.5	-1.9	0.9	0.8	0.8	0.0	-0.8
Medication: Aspirin	0.4	0.5	0.9	0.7	-1.0	-0.6	0.6	0.7	-0.6	-0.9	-0.7
Medication: Gliclazide	1.1	1.3	5.6	-0.3	-0.1	-2.4	0.6	0.1	0.3	-0.7	-1.9
Illnesses of father: None of the above (group 1)	0.3	0.3	1.2	0.5	1.0	0.1	0.1	0.1	0.5	0.2	1.1
Smoking status: Current	1.7	2.7	7.2	0.7	1.6	-0.4	0.9	1.6	-1.1	2.7	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.2	0.9	-1.3	-1.4	0.6	0.6	-0.5	-2.1	-1.0
Whole body water mass	0.2	1.3	2.4	-1.2	-0.5	0.6	-0.7	-1.4	1.5	-1.4	-1.1
Leg predicted mass (right)	0.2	1.3	3.2	-1.4	0.1	0.7	-0.9	-1.6	1.8	-0.7	-0.9
Arm fat mass (left)	0.6	2.4	4.8	-2.0	-1.3	-0.1	-1.4	-2.0	1.1	-1.3	-2.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.0	1.4	-1.0	-0.8	1.4	1.3	-1.1	-0.5	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	2.2	0.3	1.5	-1.1	1.2	0.7	0.7	-0.1	-0.4
Miserableness	0.1	0.2	0.6	-0.6	-0.2	0.5	-0.1	-0.8	0.2	0.1	-0.5
Guilty feelings	0.5	0.7	2.5	0.9	0.2	0.0	1.6	1.1	-0.5	-0.1	-1.0
Wears glasses or contact lenses	0.2	0.2	0.8	0.1	-0.6	0.5	-0.1	0.3	-0.9	-0.1	0.2
Ever taken oral contraceptive pill	0.1	0.2	0.4	-0.4	0.2	0.5	-0.3	-0.0	0.7	-0.1	0.5
Hearing aid user	1.1	1.2	2.7	-0.8	1.5	0.7	-0.8	-1.0	1.4	1.6	0.6
Mother’s age at death	0.4	0.4	1.3	-1.1	0.3	-0.3	-0.5	-0.4	1.1	0.3	-0.6
Financial situation satisfaction	1.0	1.2	2.6	1.4	-0.2	-1.6	1.1	1.6	-1.0	0.4	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.7	-0.1	-0.3	0.6	0.7	-0.4	0.1	1.1
Commuting to job workplace: Public transport	0.1	0.2	0.8	0.3	-0.1	-0.9	0.5	0.3	0.2	0.1	-0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.1	-0.7	0.2	-0.5	0.1	-0.6	0.1	0.7
Medication: Blood pressure	0.4	0.8	2.9	-0.9	-0.0	0.7	-0.5	-0.5	0.6	-1.1	-1.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.4	0.8	1.2	-1.1	1.2	0.9	0.7	-0.4	-0.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.2	-1.1	-1.0	0.6	-1.0	-1.0	0.5	-0.9	-0.6
High cholesterol (Self-reported)	0.5	0.8	2.3	1.0	-0.4	-1.5	1.2	1.2	-0.0	-0.4	-0.1
Medication: Bendroflumethiazide	0.5	0.7	2.8	-0.7	1.2	0.7	-0.2	-0.2	1.7	-0.4	-0.5
Medication: Paracetamol	0.1	0.2	0.8	-0.1	0.9	-0.1	0.1	-0.1	-0.5	0.8	0.2
Medication: Lisinopril	0.7	0.9	1.5	-1.2	0.0	1.2	-1.0	-1.2	1.1	-0.8	-0.4
Medication: Atorvastatin	2.4	3.0	6.6	-2.6	-1.2	0.5	-2.3	-2.5	0.7	0.3	-1.7
Illnesses of father: High blood pressure	1.2	1.5	3.7	-1.8	-0.9	1.2	-1.9	-1.6	-0.3	-0.5	0.4
Alcohol drinker status: Never	0.8	0.9	3.2	-0.4	-1.8	0.7	-0.2	-0.2	-0.9	-1.4	-0.9
Ever smoked	0.4	0.7	2.4	-0.6	1.1	0.6	0.2	0.4	1.5	-0.9	-0.6
Basal metabolic rate	0.3	1.6	2.6	-1.5	-0.6	0.5	-0.9	-1.6	1.6	-1.4	-1.4
Leg fat percentage (left)	0.3	1.1	3.4	-0.6	-1.2	-1.4	-0.3	-0.6	0.1	-1.1	-1.8
Arm fat-free mass (left)	0.3	1.4	3.4	-1.2	-0.8	0.3	-0.6	-1.2	1.3	-1.9	-1.4
Number of operations (self-reported)	3.0	4.5	9.8	-2.2	-3.1	0.7	-2.2	-2.5	-1.8	-2.1	-1.5
Average weekly beer plus cider intake	1.0	1.4	2.5	1.3	0.8	-0.8	1.1	1.6	0.6	1.3	1.6
Irritability	3.2	5.4	13.7	3.2	1.4	-2.5	3.7	3.3	-0.0	0.3	-0.1
Risk taking	3.6	5.2	10.9	3.3	0.6	-3.1	2.6	3.1	-1.3	-0.3	1.5
Ever had prostate specific antigen (PSA) test	0.4	0.4	2.1	0.3	-0.4	-1.4	0.7	0.4	0.1	-0.2	-0.5
Fractured/broken bones in last 5 years	1.8	2.3	4.8	-2.1	-0.6	1.7	-1.8	-2.2	1.1	0.8	-0.8
Age started oral contraceptive pill	0.9	1.1	2.8	-1.4	0.5	1.7	-1.6	-0.6	-0.0	0.7	0.8
Diastolic blood pressure, automated reading	0.1	0.4	1.5	-0.4	0.2	1.2	-0.9	-0.6	0.7	0.1	-0.0
Ever depressed for a whole week	0.2	0.2	1.0	-0.1	0.1	-0.6	0.0	-0.1	1.0	0.8	-0.1
Unable to work because of sickness or disability	0.3	0.4	1.4	-0.4	-0.9	0.6	-0.6	-0.6	-1.2	0.1	0.4
Commuting to job workplace: Cycle	0.7	0.8	3.0	0.7	-0.3	-1.7	1.4	0.5	-0.5	-0.1	-0.9
Myopia	0.7	1.1	5.1	0.6	0.7	-2.2	0.7	0.7	0.0	1.3	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.3	0.1	1.6	-0.2	-0.1	0.0	0.3	1.3	1.8
Cholesterol lowering medication	1.1	1.7	4.8	0.3	-2.2	-0.3	-0.0	0.1	-1.1	-1.6	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.7	-0.2	-0.3	-0.4	-0.5	-0.1	-0.5	0.7
Pain experienced in last month	0.7	1.2	2.5	-1.0	1.6	0.9	-1.4	-0.9	1.2	1.0	0.4
Supplements: Calcium	0.7	0.8	5.9	0.0	0.1	0.1	-0.1	-0.6	-0.1	2.4	-0.3
Basal cell carcinoma (self-reported)	0.6	0.7	3.1	0.6	-0.2	-0.1	1.1	0.6	-0.1	-0.8	-1.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.7	-0.6	-0.3	-0.0	-0.2	-0.1	-0.1	-0.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.9	0.7	-0.9	0.8	0.4	0.5	0.2	-0.1
Heart disease (siblings)	0.6	0.7	1.9	-1.0	-0.3	-0.3	-0.6	-0.6	1.4	-1.2	-0.9
Alcohol drinker status: Previous	1.2	1.4	4.8	0.9	0.6	-2.2	1.4	1.3	0.3	-0.2	-1.0
Pack years of smoking	1.4	2.1	4.8	-2.0	1.3	-0.2	-1.5	-1.5	1.2	2.2	0.3
Impedance of whole body	0.4	2.2	7.1	0.6	0.2	1.2	0.2	0.9	-2.4	1.4	2.7
Leg fat mass (left)	0.3	1.1	3.5	-0.8	-0.6	-1.3	-0.3	-0.9	1.0	-1.0	-1.9
Arm predicted mass (left)	0.2	1.3	2.9	-1.2	-0.7	0.2	-0.6	-1.2	1.4	-1.7	-1.3