Hub : Genes

EI24

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0900	0.0340	4.9e-04	0.008	NA	-0.002	NA	-0.002	6.6e-02	NA	4.9e-01	NA	4.6e-01
2	GTEx	Testis	0.1280	0.0490	1.1e-03	0.137	NA	0.026	NA	0.095	1.1e-06	NA	2.5e-02	NA	5.5e-05
3	GTEx	Thyroid	0.1200	0.0490	8.2e-03	0.010	NA	0.007	NA	0.009	5.3e-02	NA	8.5e-02	NA	6.7e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.1002	0.0311	1.4e-05	0.031	0.044	0.066	0.051	0.061	6.5e-05	2.1e-06	6.8e-09	3.3e-07	2.4e-08
5	TCGA	Pheochromocytoma and Paraganglioma	0.3210	0.1280	5.1e-03	0.056	0.059	0.079	NA	0.036	2.9e-03	2.3e-03	4.6e-04	NA	1.5e-02
6	TCGA	Prostate Adenocarcinoma	0.0853	0.0493	9.1e-03	0.002	0.022	0.026	NA	0.002	1.7e-01	2.3e-03	9.5e-04	NA	1.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.2	0.7	-0.0	-0.4	0.0	-0.1	-0.8	-0.6
Bipolar Disorder or Schizophrenia	0.8	1.8	6.2	-1.3	-2.5	-0.3	0.1	-1.7	-0.4
Depressed Affect (Nagel 2018)	1.0	2.1	4.2	-1.6	-1.4	-1.1	-1.2	-1.1	-2.0
Depression (Nagel 2018)	0.4	0.6	2.3	-0.5	-0.2	-1.5	-0.3	-0.4	-0.9
Intelligence (Savage-Jansen 2018)	1.0	3.0	10.9	0.4	3.3	-0.0	1.6	2.0	0.5
Neuroticism (Nagel 2018)	1.4	3.4	5.9	-1.5	-2.1	-0.8	-1.6	-2.4	-2.1
Schizophrenia (2018)	1.1	2.3	8.4	-1.6	-2.9	-0.4	0.2	-1.6	-0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	1.5	1.2	-0.7	-0.6	-0.2	-1.2	0.7
Worry (Nagel 2018)	1.1	2.4	5.9	-0.2	-1.0	-1.2	-2.4	-1.7	-1.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.7	-1.3	-1.0	0.3	0.1	0.4
Alzheimer’s Disease (in father)	0.9	0.9	2.7	-0.6	-1.6	0.7	-0.1	-1.3	-0.6
Alzheimer’s Disease (including proxy)	0.8	1.1	3.7	-1.1	-1.9	-1.2	-0.1	-0.6	-0.1
Crohns Disease (2017)	1.3	2.9	8.1	0.3	0.8	-1.5	-2.8	-2.0	-1.5
Irritable Bowel Disease (IBD)	1.3	3.1	9.2	0.5	1.5	-1.4	-3.0	-0.9	-1.9
Ulcerative Colitis (UC)	1.0	1.9	4.2	0.6	1.9	-1.0	-2.1	0.8	-1.4
Major Depression (MDD)	2.4	2.9	7.2	-2.1	-0.1	-1.6	-1.7	0.2	-2.7
Reaction Time	1.7	3.2	5.6	-1.7	-2.4	-1.6	-1.0	-2.3	-1.5
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.4	0.9	2.7	-0.7	1.6	2.1	1.9
Breast Cancer	0.5	1.2	3.2	0.7	-0.3	1.0	1.8	-1.2	0.8
Ovarian Cancer	1.2	1.6	3.1	0.8	-0.7	1.7	1.8	0.7	1.5
Prostate Cancer	1.6	2.3	5.7	1.6	2.4	-0.5	0.5	2.1	0.6
Age at First Birth	0.2	0.3	0.8	-0.6	-0.4	-0.9	-0.5	-0.6	0.1
Bipolar Disorder (2011)	1.0	0.9	2.2	0.1	-0.8	-1.2	-1.5	-1.0	-0.5
Body Mass Index (BMI) (2010)	0.8	1.1	2.5	-1.5	0.9	-0.8	-0.5	0.3	-1.6
Coronary Artery Disease (CAD)	0.1	0.2	0.5	0.2	-0.3	0.7	-0.6	0.3	-0.0
Crohns Disease (2012)	0.5	0.7	2.1	-0.2	0.2	-0.1	-1.3	-0.7	-1.4
Mean Putamen Volume	0.5	0.6	2.3	-0.1	-0.1	-0.3	-1.5	-0.6	-0.8
Fasting Glucose	1.0	1.2	3.4	-0.0	-0.7	0.2	-1.3	-1.8	-1.2
HbA1C	1.8	2.0	3.6	0.4	1.7	-1.8	-1.9	-0.9	-1.2
HDL Cholesterol	0.5	0.8	2.3	0.4	-1.4	-1.5	-0.0	-0.4	0.4
LDL Cholesterol	0.4	0.6	1.8	0.1	0.2	-0.7	-0.3	-1.3	-1.0
Lupus	0.2	0.2	0.9	0.1	0.1	0.2	-0.9	-0.0	0.7
Neuroticism (2016)	2.7	3.8	7.1	-1.6	-2.4	0.6	-0.8	-2.6	-2.7
Primary Biliary Cirrhosis	1.7	2.4	7.0	-2.6	-0.9	-0.9	1.5	0.3	-2.0
Rheumatoid Arthritis	0.3	0.4	1.4	0.6	-0.1	-0.0	-0.3	-1.2	-0.7
Schizophrenia (2014)	1.2	2.7	11.0	-0.8	-3.3	-0.2	0.3	-2.1	0.5
Triglycerides	1.4	2.3	6.8	1.1	2.6	1.2	0.9	1.8	-0.0
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.5	-1.9	-1.2	-1.1	-0.9	-1.1	-1.6
Ulcerative Colitis	0.5	0.8	2.3	-0.7	0.4	-0.9	-0.7	0.7	-1.5
Blood Eosinophil Count	0.1	0.8	1.5	-0.4	-0.9	0.9	1.2	0.9	0.9
Blood Platelet Count	0.3	3.1	11.9	-0.8	2.3	0.4	0.6	3.5	-0.1
Blood Red Count	0.0	0.2	0.5	-0.2	-0.2	-0.7	-0.0	-0.5	-0.2
Blood White Count	0.2	1.7	5.5	-0.3	0.6	-2.3	-1.1	-0.8	-1.5
Heel T-Score	1.8	13.9	36.4	-3.6	-5.0	1.3	1.9	-6.0	-2.0
BMI	0.5	3.2	9.6	-3.1	-0.3	-0.5	2.5	-0.9	-1.4
Height	0.3	5.9	14.6	3.8	1.6	0.2	-3.0	2.9	1.0
Waist Hip Ratio (WHR)	0.5	2.3	5.3	-0.2	-0.9	0.0	2.3	1.8	2.0
Systolic Blood Pressure	0.1	0.7	2.3	1.5	0.5	0.4	0.4	0.9	0.8
Smoking Status	0.9	2.1	6.1	-0.3	-2.1	-0.6	-0.7	-2.5	-1.2
Allergy or Eczema	0.5	1.3	2.0	-0.9	-1.2	1.3	0.7	-1.4	-1.1
Cardiovascular Disease	0.1	0.3	0.9	-0.7	-0.1	-0.1	-0.1	0.6	-1.0
Hypothyroidism (self reported)	0.2	0.4	1.2	-0.2	1.1	-0.8	-0.8	-0.2	-0.5
Respiratory disease	0.2	0.5	1.6	-0.8	-0.8	-0.1	0.1	-1.3	-0.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.0	-1.6	0.0	-1.4	1.5	-0.3	-2.0
Lung FEV1/FVC ratio	1.8	9.1	33.1	-5.8	-3.9	-1.2	1.5	-0.9	-1.4
Lung FVC	1.2	6.0	22.4	1.6	2.3	-2.0	-1.0	4.7	0.9
Neuroticism	0.6	1.4	2.9	-0.8	-0.9	-1.0	-1.2	-1.3	-1.7
Chronotype (morning person)	1.4	3.3	7.3	1.8	2.0	0.5	0.3	2.7	2.1
Hair Pigment	0.0	0.7	1.8	1.4	1.1	-0.4	-0.6	-0.6	-0.2
Tanning	0.2	2.0	5.5	-1.4	-0.7	-2.3	-1.6	0.1	-1.1
Hand grip strength (left)	0.7	1.8	4.1	2.0	0.9	-1.0	-1.1	-0.1	2.0
Number of treatments/medications taken	0.7	1.2	2.3	-0.9	-0.9	-1.5	-0.9	-1.2	-1.0
Average weekly spirits intake	3.0	3.7	8.6	-1.9	-0.9	-2.9	-1.3	-0.8	-2.6
Sensitivity / hurt feelings	1.0	1.7	7.1	0.1	-0.8	-0.9	-1.2	-2.7	-0.4
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.5	-1.3	-1.1	-1.3	-0.1	-2.4	-2.0
Hearing difficulty/problems: Yes	4.2	6.5	19.6	-2.0	-3.0	1.0	-1.0	-4.4	-2.1
Relative age of first facial hair	0.4	0.8	1.6	1.3	1.2	0.2	-1.1	0.6	0.1
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.8	-1.7	-2.4	0.4	0.1	-1.5	-0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.0	0.3	-0.1	0.7	0.5	0.6
Ever had hysterectomy (womb removed)	2.4	2.7	4.9	0.8	1.9	1.4	1.9	2.2	1.5
Systolic blood pressure, automated reading	1.7	4.9	6.8	2.6	1.4	2.2	2.3	1.9	2.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.8	-0.1	-0.2	0.4	-0.7	-0.2	-0.9
Angina	1.4	1.9	5.9	-2.4	0.1	0.5	1.2	0.5	-1.8
Medication for hormone replacement therapy	0.4	0.5	1.0	-0.2	-0.8	-0.5	-0.6	1.0	0.7
Vitamin and mineral supplements	0.5	0.7	1.4	-0.9	-1.2	1.1	0.0	0.6	0.3
Supplements: Zinc	0.7	0.8	1.7	0.4	1.3	-0.1	-0.4	-1.2	-1.2
Medication: Co-codamol	1.0	1.1	3.7	-1.0	-1.9	0.8	-0.8	-0.9	0.2
Medication: Metformin	1.1	1.6	4.6	-1.5	-0.3	0.3	2.2	1.3	-0.9
Diabetes (father)	2.0	2.5	5.4	-2.3	-2.2	0.0	2.2	-0.2	0.1
Diabetes (mother)	1.0	1.3	4.8	-1.1	0.4	0.4	1.1	2.2	-0.4
Severe depression (siblings)	1.9	2.1	5.2	-1.7	-1.0	-1.0	0.7	-2.3	-1.5
Pack years adult smoking proportion	1.1	1.6	2.9	1.7	1.4	1.7	1.0	-0.0	1.1
Impedance of leg (right)	0.3	1.3	4.4	-0.1	-1.5	2.1	0.3	0.8	0.4
Leg fat-free mass (left)	0.1	0.4	1.8	0.6	1.3	-0.2	-0.1	-0.5	-0.3
Trunk fat percentage	0.2	0.8	2.1	0.4	1.3	1.5	0.7	-0.5	-0.1
Hand grip strength (right)	0.4	1.2	3.0	1.6	1.7	-0.5	0.1	0.3	1.2
Townsend deprivation index at recruitment	1.4	1.9	5.9	-1.4	-1.5	-0.3	0.1	-2.4	-1.2
Current tobacco smoking	0.9	1.5	6.2	0.7	-1.2	-0.4	-0.9	-2.5	-0.3
Average weekly fortified wine intake	1.4	1.6	4.0	-1.4	-1.5	-0.3	0.3	-2.0	-1.1
Maternal smoking around birth	0.7	1.0	2.4	-1.5	-1.2	-0.4	-0.9	-0.9	-0.9
Fed-up feelings	3.0	5.4	10.2	-3.2	-2.5	-0.3	-1.1	-2.6	-2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.5	0.3	-0.4	-1.4	-1.3	-1.9	-0.8
Relative age voice broke	1.4	2.1	4.1	0.9	1.9	-2.0	-2.0	0.2	-0.4
Taking other prescription medications	0.3	0.5	1.4	0.3	0.7	-1.2	-0.5	0.2	-0.9
Age when periods started (menarche)	2.0	4.7	12.6	3.5	1.0	2.5	0.9	0.1	2.8
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.8	-0.0	1.1	-1.2	0.8	1.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	-0.6	0.1	1.1	0.6	-0.1	-1.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.5	0.4	-0.1	0.2	-0.4	0.2
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.3	0.4	-0.4	0.3	-0.3	-0.7
Serious illness, injury or assault to yourself	0.6	0.8	1.4	-0.6	-0.0	-1.0	-0.9	-1.1	-1.2
High blood pressure	0.2	0.5	1.4	-0.9	0.4	-1.2	0.3	0.3	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.0	-0.3	-0.4	0.9	1.0	-0.9	-0.9
Multivitamins +/- minerals	0.4	0.6	1.2	1.1	0.9	-0.6	-0.0	-1.0	-0.1
Stomach or abdominal pain in last month	0.7	0.9	1.9	-1.3	-1.4	-0.1	-0.1	-1.0	-0.7
Supplements: Glucosamine	1.0	1.3	2.8	0.7	1.7	-1.7	-1.0	0.8	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	0.4	1.1	0.1	-0.1	0.5	0.4
Medication: Atenolol	1.1	1.3	2.7	-0.5	-0.8	-1.6	-1.3	-1.4	-1.0
Medication: Levothyroxine sodium	0.2	0.3	0.7	-0.2	0.8	0.9	-0.1	0.7	-0.3
Sitting height	1.4	9.6	28.8	5.4	3.7	0.4	-2.2	2.4	2.1
Chronic bronchitis/emphysema (father)	0.5	0.5	1.3	0.1	0.4	0.7	1.0	-0.6	-1.1
High blood pressure (mother)	0.2	0.3	0.7	0.2	-0.0	0.6	0.8	0.4	0.5
Body mass index (BMI)	0.3	1.2	2.6	-1.0	1.3	0.3	1.6	-0.8	-1.2
Impedance of leg (left)	0.2	1.0	3.0	0.3	-1.7	1.6	-0.7	0.4	0.3
Leg predicted mass (left)	0.1	0.4	1.7	0.5	1.3	-0.2	-0.1	-0.5	-0.4
Trunk fat mass	0.1	0.6	1.4	0.2	1.2	1.1	0.9	-0.2	-0.2
Waist circumference	0.2	0.7	3.4	-0.8	0.6	0.3	1.8	0.0	-0.0
Number of incorrect matches in round	0.2	0.4	0.9	0.1	-0.3	0.7	-0.8	-1.0	0.0
Past tobacco smoking	0.5	0.9	2.6	-0.1	-0.2	1.0	1.2	0.1	1.6
Alcohol usually taken with meals	1.4	2.3	4.4	0.7	2.1	-1.9	-1.3	1.5	1.1
Nervous feelings	1.0	1.9	4.3	1.8	-1.0	-0.0	-1.5	-2.1	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.5	-0.9	-1.7	-0.3	-0.9	-1.9	-1.4
Hearing difficulty/problems with background noise	3.8	6.1	20.1	-1.2	-3.5	-0.3	-1.2	-4.5	-1.0
Hair/balding pattern: Pattern 2	1.4	1.7	3.7	-0.6	-1.0	-1.9	-1.5	-1.3	-1.2
Had menopause	0.1	0.1	0.5	0.3	0.3	0.7	-0.2	0.4	0.3
Had other major operations	0.8	1.0	3.0	-1.7	-0.2	0.5	0.9	-0.2	-1.4
Forced vital capacity (FVC)	0.6	2.5	6.9	1.5	1.1	-1.1	-1.5	2.6	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.9	-0.8	0.0	0.3	0.0	-1.4	-1.7
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	6.2	-0.5	0.6	-2.5	-0.9	-1.5	-2.1
Qualifications: None of the above	0.6	1.3	4.2	-0.7	-0.5	-0.4	-1.5	-0.4	-2.1
Financial difficulties in last 2 years	0.6	0.8	2.1	-0.6	-0.0	-1.5	0.5	-1.1	-1.0
Mouth/teeth dental problems	0.4	0.7	2.2	1.5	-0.1	-0.2	-0.5	-0.7	1.0
Heart attack	0.8	1.0	2.6	-0.4	0.1	-1.6	-1.2	0.0	-1.4
Allergy	0.3	0.6	1.3	0.3	0.4	-0.6	-0.7	1.1	1.1
Pain all over the body in last month	0.6	0.6	1.6	-0.6	-1.0	-1.3	-0.7	-0.6	-0.4
Diabetes (self-reported)	0.7	1.1	3.0	-0.9	-0.4	0.2	1.7	0.1	-1.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.7	-0.8	-0.0	-0.9	-0.8	-1.5	-1.9
Medication: Ramipril	0.8	1.0	2.9	1.0	1.7	0.0	0.5	1.4	0.3
Medication: Simvastatin	2.4	3.5	11.2	-1.5	-3.3	2.2	1.1	-1.1	0.1
Fluid intelligence score	1.6	3.4	5.4	0.8	2.3	-0.6	2.3	2.0	2.2
Illnesses of siblings	0.4	0.5	1.0	-0.4	-0.9	0.3	-1.0	-0.4	0.8
Neuroticism score	1.4	2.9	6.7	-1.1	-1.6	-0.7	-1.3	-2.6	-2.2
Weight	0.1	0.5	2.0	0.3	1.4	0.4	0.4	-0.3	-0.7
Impedance of arm (right)	0.4	1.7	4.7	1.9	-0.2	1.3	-2.2	-0.3	0.4
Arm fat percentage (right)	0.3	1.0	1.8	-0.7	0.9	0.8	0.7	-1.4	-1.4
Trunk fat-free mass	0.0	0.2	0.6	0.4	0.8	-0.5	-0.1	0.1	-0.4
Hip circumference	0.2	0.7	1.4	-0.2	1.2	1.0	0.5	-0.8	-1.0
Time employed in main current job	0.8	1.0	2.8	0.0	-0.1	1.4	1.7	0.6	0.9
Alcohol intake versus 10 years previously	0.4	0.6	1.5	-0.3	1.0	0.0	-1.2	0.2	-1.0
Father’s age at death	0.5	0.6	2.0	0.3	0.0	0.5	1.2	0.2	1.4
Worrier / anxious feelings	0.6	1.1	4.7	0.3	0.4	-1.0	-2.2	-0.7	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.8	-0.3	-1.1	-0.5	0.1	-1.7	-0.5
Falls in the last year	0.7	0.9	1.6	1.3	0.7	0.9	-0.4	1.2	0.9
Hair/balding pattern: Pattern 3	0.7	1.1	4.7	0.6	2.2	1.1	0.1	0.4	-0.0
Number of live births	0.2	0.3	0.6	0.5	-0.4	0.3	-0.7	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.5	-0.3	-0.2	-0.8	-0.7	1.9	0.5
Pulse rate	0.0	0.1	0.2	0.2	0.1	-0.4	0.5	-0.1	0.1
Happiness	0.3	0.4	0.8	-0.2	-0.3	-0.3	0.9	-0.9	-0.6
Noisy workplace	0.5	0.7	1.2	-0.5	-1.1	1.0	-0.6	-0.6	-0.9
Qualifications: A levels/AS levels or equivalent	1.5	3.4	8.3	-1.5	-0.8	-2.6	-0.8	-2.9	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	4.5	-2.1	-1.4	-0.1	0.1	-0.1	-1.0
Mouth/teeth dental problems: Dentures	1.9	3.3	8.5	1.6	2.1	1.7	0.4	2.9	1.1
Asthma	0.3	0.7	2.2	-0.8	-0.1	-0.3	0.1	-1.0	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.9	-2.0	-0.4	-1.9	-0.6	-0.6	0.2
Medication: Cholesterol lowering	1.0	1.6	4.5	-1.6	-2.1	0.0	-0.4	-0.9	-1.2
Depression (self-reported)	1.6	1.9	5.4	-0.9	-0.3	-2.0	-0.7	-1.0	-2.3
Medication: Lansoprazole	0.3	0.4	1.3	-0.5	-1.1	0.2	0.1	0.7	0.4
Prospective memory result	1.2	1.5	4.0	-0.2	-2.0	0.6	-1.4	-1.7	-0.0
Lung cancer (father)	4.1	4.8	14.5	0.6	1.4	1.7	1.8	3.8	2.5
Illnesses of mother	0.6	0.7	2.8	0.1	-0.7	0.7	-0.5	-1.7	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	5.5	-0.0	-0.2	-0.7	-0.7	2.3	0.8
Pulse wave Arterial Stiffness index	0.9	1.0	3.2	0.0	-1.8	0.4	0.1	0.3	1.6
Impedance of arm (left)	0.4	1.7	4.3	2.1	0.5	1.7	-1.4	0.3	0.7
Arm fat mass (right)	0.2	0.9	1.5	-0.4	1.2	0.7	1.0	-0.9	-1.1
Trunk predicted mass	0.0	0.2	0.6	0.4	0.8	-0.6	-0.2	0.1	-0.4
Standing height	0.3	3.0	8.8	3.0	0.6	0.6	-2.3	1.1	1.3
Length of working week for main job	0.4	0.4	1.1	-0.5	-0.8	0.3	0.3	1.1	0.4
Exposure to tobacco smoke at home	0.5	0.5	2.8	0.2	-0.4	1.7	-0.0	-0.3	0.3
Breastfed as a baby	0.9	1.2	2.7	-0.4	1.4	-0.8	1.1	1.6	0.5
Tense / ‘highly strung’	1.0	1.6	5.5	0.1	-1.4	0.2	-0.6	-2.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.8	11.6	-1.5	-1.1	-1.6	-1.0	-3.1	-3.4
Hair/balding pattern: Pattern 4	0.6	1.6	4.0	-2.0	-1.4	-0.3	1.4	1.1	0.1
Birth weight of first child	0.2	0.3	1.0	-0.2	-1.0	-0.5	-0.5	-0.0	0.6
Peak expiratory flow (PEF)	0.2	0.5	1.9	-0.8	-0.0	-1.4	-0.4	0.3	-0.5
Pulse wave reflection index	1.4	1.7	6.9	-0.1	-2.6	0.1	-0.0	-0.8	1.7
Ever highly irritable/argumentative for 2 days	2.6	3.2	8.6	-1.8	-1.6	-1.1	-0.4	-1.7	-2.9
Loud music exposure frequency	0.9	1.0	2.4	1.6	1.2	0.4	-1.0	-0.8	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.2	0.4	1.1	0.8	0.8	-0.5	-0.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.6	-1.9	-1.4	-0.6	-0.8	-1.5	-1.4
Blood clot in the leg (DVT)	0.3	0.3	1.1	-1.1	-0.2	-0.0	0.5	-0.6	-0.5
Medication: Paracetamol	0.5	0.8	1.3	-1.0	-0.2	-1.2	-0.5	-1.1	-0.9
Headache pain in last month	1.0	1.8	4.1	-1.6	-2.0	-1.0	-0.3	-1.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.2	1.5	1.3	1.3	1.0	-0.5	1.1
Glaucoma (self-reported)	0.1	0.1	0.4	-0.2	0.1	0.3	0.6	-0.1	0.1
Gout (self-reported)	0.4	0.5	1.3	-0.1	1.1	-0.3	-0.7	-0.1	-1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	-0.3	0.4	-0.3	-0.9	-0.1	-0.4
Medication: Amlodipine	0.4	0.5	1.8	-0.4	-1.4	-0.3	-0.9	0.1	0.5
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.1	-1.1	-1.8	-1.0	0.2	-0.7	-0.3
Birth weight	1.1	2.3	4.8	1.7	1.7	-1.6	0.1	2.2	1.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	0.4	0.0	0.9	0.7	-0.6	0.5
High blood pressure (siblings)	0.4	0.6	1.5	-0.3	0.1	-1.1	0.3	-0.7	-1.2
Forced vital capacity (FVC), Best measure	0.7	2.4	7.9	1.2	0.7	-1.2	-1.4	2.8	1.0
Body fat percentage	0.2	0.7	1.3	-0.5	0.8	1.2	1.1	-0.6	-0.5
Leg fat percentage (right)	0.5	1.7	4.6	-1.7	0.1	1.2	2.1	-0.2	-1.0
Arm fat-free mass (right)	0.0	0.2	0.8	0.1	0.9	-0.2	0.6	0.4	0.2
Exposure to tobacco smoke outside home	1.0	1.4	3.1	-1.7	-1.8	0.5	1.4	-0.0	0.3
Comparative body size at age 10	0.5	1.3	3.1	-1.8	-0.6	-0.8	1.7	-0.4	-0.7
Number of full brothers	0.7	0.9	2.9	0.7	-0.9	1.7	-0.5	0.9	0.6
Worry too long after embarrassment	0.6	1.1	2.5	0.3	-0.4	-0.6	-1.6	-1.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.7	-0.7	-0.0	-0.3	0.6	-0.8
Wheeze or whistling in the chest in last year	1.0	1.7	4.9	0.2	-2.2	1.2	0.6	-1.9	0.4
Number of children fathered	1.1	1.2	4.8	0.5	0.5	-2.2	-0.6	0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.1	0.2	-0.8	-1.0	-0.5	-0.2	-0.1
Age at first live birth	0.5	1.0	2.5	0.3	-0.1	-1.5	-1.6	-0.6	0.7
Pulse wave peak to peak time	1.0	1.2	4.0	0.1	2.0	-0.4	-0.3	-0.2	-1.6
Health satisfaction	0.8	1.0	2.3	-0.9	-0.5	-1.5	-0.7	0.4	-1.5
Shortness of breath walking on level ground	1.5	1.8	3.7	-1.9	-1.3	-1.6	-0.9	-0.3	-1.5
Qualifications: College or University degree	0.8	2.4	5.3	-2.3	-2.2	-0.7	1.1	-1.3	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.8	-0.1	-0.3	-0.9	0.4	0.2	-0.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.0	-1.7	-1.5	-0.8	1.4	-0.2	-0.2
Emphysema/chronic bronchitis	1.9	2.2	5.7	-1.6	-2.4	0.3	0.0	-1.8	-1.0
Medication for pain relief, constipation, heartburn	1.0	1.8	7.3	1.6	0.5	2.7	0.0	0.4	0.4
Neck or shoulder pain in last month	0.9	1.3	5.2	-2.3	-1.2	0.3	0.0	-0.4	-0.9
Medication: Blood pressure	0.5	0.9	3.2	-0.8	0.1	-1.8	-0.1	1.2	-0.3
Angina (self-reported)	1.5	2.0	6.2	-2.5	0.1	0.2	1.1	0.3	-2.1
Migraine (self-reported)	0.4	0.5	2.0	-0.3	-0.2	-0.0	-0.5	-1.4	-0.9
Medication: Ibuprofen	0.8	0.9	3.5	-0.9	0.2	-1.9	-0.8	-0.5	0.6
Medication: Allopurinol	0.1	0.2	0.7	0.4	0.8	0.3	0.1	-0.3	-0.3
Medication: Omeprazole	0.8	1.0	2.5	0.3	1.1	-1.6	-0.9	1.0	0.2
Medication: Seretide 50 evohaler	1.5	1.8	5.4	2.1	0.6	-0.1	0.2	0.4	2.3
Mean time to correctly identify matches	1.3	2.5	4.5	-0.6	-2.1	-1.8	-1.7	-1.9	-0.7
Heart disease (mother)	0.1	0.2	0.4	0.6	0.2	0.1	-0.4	0.4	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	5.7	-0.5	-0.7	1.5	1.6	1.5	2.4
Whole body fat mass	0.1	0.6	1.1	-0.2	1.0	1.0	0.9	-0.5	-0.5
Leg fat mass (right)	0.2	0.8	1.8	-1.1	0.3	0.8	1.4	-0.6	-0.9
Arm predicted mass (right)	0.0	0.2	0.4	-0.1	0.6	-0.3	0.6	0.3	-0.0
Pulse rate, automated reading	0.7	2.1	7.7	0.5	0.8	1.1	2.8	1.2	1.2
Alcohol intake frequency.	0.2	0.6	1.7	-1.1	-0.6	0.2	1.3	0.1	0.1
Comparative height size at age 10	0.2	1.1	2.2	0.6	-1.1	0.9	-0.1	1.5	1.5
Number of full sisters	0.4	0.5	1.0	-0.2	1.0	0.6	0.5	0.7	0.9
Suffer from ‘nerves’	1.4	2.2	5.0	-0.5	-1.0	0.2	-1.5	-2.1	-2.2
Overall health rating	1.0	2.2	6.8	-1.8	-1.4	-0.0	-0.4	-0.9	-2.6
Chest pain or discomfort	1.7	2.4	8.1	-2.9	-1.4	-0.5	-0.1	-1.0	-1.8
Had major operations	0.2	0.2	0.4	-0.3	-0.1	0.2	0.6	0.5	0.5
Age at last live birth	0.7	1.0	2.1	0.8	-0.6	-1.3	-1.4	-1.1	0.5
Family relationship satisfaction	0.6	0.7	1.7	-0.1	-1.3	0.9	-0.5	-1.2	0.3
Leg pain on walking	1.8	2.3	4.8	-2.0	-1.5	-1.0	-1.1	-0.7	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.3	-0.5	0.7	0.3	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.1	0.2	1.0	-0.2	0.0	-0.0	-0.6
Illness, injury, bereavement, stress in last 2 years	1.7	2.0	5.4	1.6	0.3	2.3	0.5	0.8	1.8
Medication: Aspirin	1.2	1.5	3.5	-1.1	-0.4	-1.5	1.5	1.9	0.2
Supplements: Vitamin C	0.1	0.1	0.2	0.3	0.5	0.2	0.5	-0.2	-0.2
Knee pain experienced in last month	1.4	2.1	7.8	-2.8	-0.7	-1.2	-1.2	0.4	-1.1
Hypertension (Self-reported)	0.2	0.4	0.8	-0.8	0.7	-0.9	-0.1	0.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	5.1	2.3	1.1	0.1	0.4	0.9	1.8
Illnesses of father: Heart disease	0.7	0.9	2.9	-1.1	-1.0	-0.4	-0.3	-0.4	-1.7
Illnesses of siblings: Diabetes	0.7	0.8	4.3	-0.3	0.0	0.0	2.1	0.4	0.5
Smoking status: Previous	0.8	1.1	2.1	-0.4	0.4	-1.3	-1.4	0.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.0	0.5	-1.3	1.4	0.8	-0.9	0.1
Whole body fat-free mass	0.1	0.3	1.3	0.6	1.1	-0.5	-0.1	-0.1	-0.2
Leg fat-free mass (right)	0.1	0.5	1.7	0.8	1.3	-0.5	-0.4	-0.5	-0.2
Arm fat percentage (left)	0.3	1.1	1.5	-0.8	1.2	0.9	1.1	-1.0	-1.2
Average weekly red wine intake	0.2	0.3	0.7	0.3	0.8	-0.6	-0.4	0.3	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.3	-0.0	1.1	-0.3	0.1	0.8	0.1
Mood swings	0.6	1.0	1.9	-0.9	-1.2	1.0	1.4	-0.8	-0.7
Loneliness, isolation	3.7	5.1	10.6	-2.8	-2.1	-1.0	-0.7	-2.5	-3.3
Long-standing illness, disability or infirmity	1.0	1.5	3.3	-1.3	-1.8	-0.6	-0.2	-1.6	-1.1
Ever had bowel cancer screening	0.7	0.8	1.9	-1.4	-1.3	0.8	0.8	0.2	0.3
Diabetes diagnosed by doctor	0.6	0.9	3.2	-0.9	-0.3	0.2	1.8	0.1	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	7.1	-2.7	-2.0	0.5	-0.8	-0.4	-2.0
Friendships satisfaction	1.6	2.0	6.1	-0.3	-2.5	1.9	0.1	-1.1	1.1
Qualifications: nursing, teaching	0.5	0.8	2.0	-1.4	-1.1	-1.1	-0.0	-0.4	-0.6
Commuting to job workplace: Walk	2.0	2.2	3.0	-1.3	-1.3	-1.7	-1.6	-1.2	-1.6
Eye problems/disorders: Cataract	0.5	0.6	2.1	0.8	1.4	0.4	-0.0	-0.4	0.8
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	8.0	-2.8	-1.7	-0.2	1.1	-0.9	-1.1
Medication for cholesterol	0.2	0.3	1.1	0.6	0.2	-0.3	-1.1	0.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.2	0.2	0.4	-1.1	-0.8	-0.1	-0.5
Back pain experienced in last month	2.1	3.1	6.4	-2.5	-1.7	-1.8	-0.7	-1.5	-1.9
Mineral and other dietary supplements	1.4	1.8	5.2	0.1	-1.5	2.3	1.3	-1.1	0.7
Breast cancer (self-reported)	1.1	1.3	3.4	-0.6	-0.6	1.9	1.4	-1.2	-0.5
Asthma (self-reported)	0.4	0.7	2.6	-0.8	0.2	-0.3	-0.0	-0.9	-1.6
Osteoporosis (self-reported)	0.3	0.4	0.9	-1.0	-0.7	0.1	-0.3	-0.4	-0.9
Osteoarthritis (self-reported)	0.5	0.7	1.9	-1.4	-0.9	0.5	0.7	0.8	0.2
Medication: Aspirin	1.0	1.3	2.7	-0.8	-0.6	-1.2	1.6	1.6	0.6
Medication: Gliclazide	0.5	0.6	1.2	-0.8	-0.4	0.1	1.1	-0.7	-1.0
Illnesses of father: None of the above (group 1)	0.5	0.6	2.1	0.8	-0.1	0.0	0.8	0.2	1.5
Smoking status: Current	0.9	1.5	6.1	0.9	-1.3	0.4	-0.2	-2.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	5.7	-1.2	-0.8	0.5	0.1	2.4	0.2
Whole body water mass	0.1	0.3	1.3	0.6	1.1	-0.5	-0.1	-0.0	-0.1
Leg predicted mass (right)	0.1	0.5	1.8	0.9	1.3	-0.5	-0.4	-0.5	-0.1
Arm fat mass (left)	0.2	1.0	2.1	-0.6	1.4	0.5	1.0	-0.8	-1.2
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	-1.4	-1.4	-0.3	0.5	-1.0	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.1	-0.8	-1.0	-0.6	0.0	-0.6	-0.3
Miserableness	0.7	1.2	2.0	0.3	0.8	-1.4	-1.4	-1.1	-1.2
Guilty feelings	0.6	0.9	2.3	-1.5	-1.3	0.1	0.9	-0.6	-0.7
Wears glasses or contact lenses	0.4	0.5	1.6	-0.1	-0.3	-1.3	-0.5	0.7	0.6
Ever taken oral contraceptive pill	0.9	1.0	2.1	-0.1	0.2	-1.4	-1.2	0.7	-1.4
Hearing aid user	0.8	0.9	2.7	1.6	1.1	-0.4	-1.0	0.0	0.6
Mother’s age at death	0.2	0.2	0.9	0.2	0.3	-0.9	-0.3	0.1	-0.4
Financial situation satisfaction	1.0	1.2	3.1	0.2	-1.8	0.9	1.6	-0.6	0.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	-0.3	-0.8	0.3	-0.8	-0.0	-0.2
Commuting to job workplace: Public transport	0.5	0.6	2.2	0.1	-0.2	-0.8	-0.2	-1.5	-1.0
Eye problems/disorders: Glaucoma	0.0	0.1	0.2	0.1	-0.2	0.1	0.2	0.3	0.4
Medication: Blood pressure	0.1	0.2	0.5	0.3	0.5	0.7	0.6	0.1	0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.5	-0.3	-0.6	1.2	0.7	0.1	1.6
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.7	-0.0	1.2	-2.2	-1.0	1.2	0.1
High cholesterol (Self-reported)	0.5	0.9	2.0	-0.8	-1.4	1.4	0.2	-0.6	-0.5
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.6	0.4	0.7	0.0	0.3	0.8
Medication: Paracetamol	0.2	0.3	0.9	-0.4	0.1	-0.7	-0.3	-1.0	-0.5
Medication: Lisinopril	1.1	1.4	5.3	0.5	1.4	-2.3	-1.0	0.4	0.0
Medication: Atorvastatin	1.5	1.8	4.8	-0.6	2.2	-1.0	-0.4	-0.6	-2.1
Illnesses of father: High blood pressure	1.5	1.9	4.3	2.1	1.8	1.0	0.1	0.9	1.5
Alcohol drinker status: Never	1.2	1.4	3.6	-0.9	0.2	-1.9	-1.5	1.2	-0.5
Ever smoked	0.6	1.1	2.7	0.7	0.1	-1.2	-0.9	-1.1	-1.6
Basal metabolic rate	0.1	0.3	1.6	0.5	1.3	-0.1	0.0	-0.2	-0.4
Leg fat percentage (left)	0.3	1.1	2.8	-1.4	0.1	0.9	1.7	-0.3	-0.9
Arm fat-free mass (left)	0.0	0.2	0.8	0.2	0.9	-0.3	0.2	-0.2	-0.3
Number of operations (self-reported)	0.7	1.1	4.2	-0.5	2.1	-0.7	0.1	1.1	-0.6
Average weekly beer plus cider intake	0.6	0.9	2.3	0.9	-1.5	0.8	0.2	-1.0	-0.8
Irritability	2.6	4.4	11.4	-2.2	-3.4	1.4	0.8	-2.6	-0.7
Risk taking	3.0	4.3	12.2	-1.5	-3.5	1.9	2.1	-0.9	1.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.6	-1.2	-0.6	-0.3	-0.1	0.4	-0.4
Fractured/broken bones in last 5 years	1.7	2.1	5.9	1.4	2.4	0.5	-2.1	0.5	-0.4
Age started oral contraceptive pill	2.2	2.7	6.4	2.5	1.0	-0.3	0.3	1.6	2.5
Diastolic blood pressure, automated reading	0.3	1.0	2.3	1.1	0.9	1.2	1.5	0.3	0.3
Ever depressed for a whole week	2.2	2.7	6.7	-0.1	-0.3	-2.6	-1.6	-2.2	-1.5
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.2	0.5	0.0	-0.8	-0.1	-0.7
Commuting to job workplace: Cycle	1.1	1.3	3.8	-1.7	-0.9	-2.0	-0.3	-0.5	-0.4
Myopia	1.0	1.4	3.0	-0.3	-1.2	1.4	1.4	-1.7	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.0	1.4	-0.1	1.4	-0.0	-0.9	0.9
Cholesterol lowering medication	0.8	1.2	2.4	-1.6	-0.2	0.4	1.4	-0.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.8	0.0	0.4	-0.9	-0.1	0.5	0.4
Pain experienced in last month	1.6	2.7	7.0	1.8	0.9	2.6	1.3	1.4	1.4
Supplements: Calcium	0.8	0.9	1.8	-0.3	0.3	-1.4	-1.0	-1.1	-1.1
Basal cell carcinoma (self-reported)	0.7	0.8	3.5	-1.9	-0.5	0.1	0.5	0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.0	-0.1	0.3	-1.2	-1.2	0.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.5	-1.2	-0.7	0.2	0.2	-1.1	-0.6
Heart disease (siblings)	0.6	0.7	3.4	0.2	0.7	-0.1	0.3	1.8	-0.4
Alcohol drinker status: Previous	2.2	2.5	8.2	-1.2	-1.8	0.5	0.1	-2.9	-1.3
Pack years of smoking	0.9	1.4	2.6	1.6	1.3	1.5	0.8	0.2	0.9
Impedance of whole body	0.3	1.4	3.8	1.5	-0.5	2.0	-1.2	0.2	0.9
Leg fat mass (left)	0.2	0.8	1.3	-1.0	0.3	0.8	1.1	-0.7	-1.0
Arm predicted mass (left)	0.0	0.2	0.8	0.3	0.9	-0.4	0.1	-0.3	-0.2