Best TWAS P=2.65e-18 · Best GWAS P=4.26e-15 conditioned to 0.000711
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | C14orf39 | 0.08 | 0.05 | lasso | 8 | 0.06 | 2.1e-05 | 7.5 | -8.1 | 3.8e-16 | -0.43 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | DHRS7 | 0.10 | 0.01 | enet | 10 | 0.06 | 2.5e-05 | -4.6 | -6.2 | 6.7e-10 | -0.17 | 0.10 | 0.47 | FALSE |
| 3 | GTEx | Muscle Skeletal | C14orf39 | 0.06 | 0.05 | lasso | 3 | 0.05 | 2.7e-05 | 7.5 | -8.7 | 2.7e-18 | -0.64 | 0.06 | 0.94 | TRUE |
| 4 | GTEx | Pituitary | C14orf39 | 0.39 | 0.38 | enet | 20 | 0.35 | 1.0e-09 | 7.5 | -8.0 | 1.2e-15 | -0.36 | 0.08 | 0.92 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | PCNXL4 | 0.15 | 0.05 | enet | 15 | 0.12 | 6.2e-07 | 2.1 | -5.5 | 3.9e-08 | -0.60 | 0.15 | 0.83 | FALSE |
| 6 | GTEx | Thyroid | DHRS7 | 0.22 | 0.12 | lasso | 11 | 0.14 | 4.0e-11 | 4.1 | -5.3 | 8.6e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | JKAMP | 0.13 | 0.06 | lasso | 2 | 0.07 | 5.3e-08 | 5.1 | 5.1 | 2.7e-07 | -0.06 | 0.00 | 1.00 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | C14orf39 | 0.02 | 0.02 | blup | 37 | 0.02 | 4.2e-03 | 7.7 | -8.2 | 1.7e-16 | -0.66 | 0.03 | 0.74 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C14orf39 | 0.08 | 0.05 | blup | 37 | 0.05 | 4.2e-03 | 6.5 | -7.9 | 2.3e-15 | -0.61 | 0.07 | 0.48 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf39 | 0.08 | 0.09 | blup | 37 | 0.11 | 1.8e-11 | 7.2 | -8.0 | 9.3e-16 | -0.61 | 0.09 | 0.91 | FALSE |