[Hub]/) : Traits : Heel T-Score : ← →

chr14:62,974,709-65,747,759

Best TWAS P=1.15e-16 · Best GWAS P=1.06e-19 conditioned to 1.3e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ZBTB1	0.06	0.00	blup	503	0.02	4.0e-03	7.3	-6.3	2.3e-10	-0.03	0.02	0.90	FALSE
2	GTEx	Adipose Subcutaneous	RP11-973N13.4	0.11	0.06	lasso	4	0.04	1.8e-04	-5.7	-6.1	1.1e-09	0.05	0.32	0.35	FALSE
3	GTEx	Artery Aorta	RP11-973N13.4	0.09	0.04	enet	14	0.06	4.8e-04	7.3	-6.0	2.2e-09	-0.01	0.04	0.94	FALSE
4	GTEx	Artery Coronary	ZBTB1	0.18	0.01	lasso	7	0.06	3.4e-03	-5.3	-6.1	1.0e-09	-0.06	0.08	0.23	FALSE
5	GTEx	Artery Tibial	CTD-2555O16.2	0.17	0.12	enet	21	0.11	3.8e-09	5.5	-6.7	2.9e-11	0.02	0.91	0.09	FALSE
6	GTEx	Artery Tibial	RP11-973N13.4	0.10	0.06	lasso	11	0.06	1.3e-05	6.4	-6.6	3.7e-11	0.02	0.32	0.67	FALSE
7	GTEx	Artery Tibial	CTD-2555O16.4	0.14	0.09	enet	15	0.07	3.0e-06	5.5	-5.7	1.2e-08	0.01	0.96	0.03	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	MTHFD1	0.27	0.10	lasso	3	0.14	1.3e-04	5.7	-6.2	4.2e-10	0.01	0.17	0.37	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	CTD-2555O16.4	0.17	-0.01	lasso	6	0.00	4.6e-01	6.4	-8.3	1.1e-16	0.01	0.05	0.58	TRUE
10	GTEx	Breast Mammary Tissue	RP11-973N13.4	0.12	0.03	lasso	3	0.06	5.6e-04	7.4	-7.8	6.9e-15	0.04	0.02	0.92	FALSE
11	GTEx	Breast Mammary Tissue (Male)	RP11-973N13.4	0.13	-0.01	enet	16	-0.01	6.6e-01	-5.0	-6.8	1.3e-11	0.07	0.04	0.44	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	MTHFD1	0.20	0.03	lasso	6	0.09	5.6e-04	2.2	7.0	3.5e-12	0.15	0.06	0.63	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CTD-2555O16.4	0.29	0.09	lasso	8	0.19	7.1e-07	-5.5	7.5	4.9e-14	0.06	0.07	0.81	FALSE
14	GTEx	Cells Transformed fibroblasts	RHOJ	0.14	0.13	enet	9	0.12	2.3e-09	8.5	-8.1	6.4e-16	-0.83	0.19	0.81	TRUE
15	GTEx	Cells Transformed fibroblasts	HSPA2	0.07	0.01	lasso	7	0.03	4.4e-03	4.9	6.5	6.9e-11	-0.07	0.23	0.64	FALSE
16	GTEx	Cells Transformed fibroblasts	PPP1R36	0.14	0.04	enet	28	0.03	4.0e-03	6.4	5.5	3.0e-08	0.01	0.12	0.87	FALSE
17	GTEx	Colon Sigmoid	RP11-973N13.4	0.18	0.01	lasso	5	0.02	4.5e-02	7.4	-7.4	1.5e-13	0.02	0.02	0.91	FALSE
18	GTEx	Colon Transverse	RP11-973N13.4	0.16	0.04	lasso	5	0.05	2.9e-03	7.4	-6.8	8.4e-12	0.04	0.04	0.94	FALSE
19	GTEx	Esophagus Mucosa	ZBTB1	0.08	0.06	lasso	5	0.03	2.5e-03	-5.0	-5.4	6.6e-08	0.01	0.37	0.40	FALSE
20	GTEx	Esophagus Muscularis	RP11-973N13.4	0.08	0.02	lasso	5	0.03	3.7e-03	6.4	-6.4	1.3e-10	0.03	0.08	0.78	FALSE
21	GTEx	Heart Left Ventricle	SYNE2	0.20	0.14	lasso	5	0.09	1.6e-05	-6.0	6.2	5.7e-10	0.04	0.38	0.58	FALSE
22	GTEx	Lung	HSPA2	0.08	0.03	lasso	5	0.02	6.8e-03	4.9	-5.3	1.2e-07	0.10	0.22	0.29	FALSE
23	GTEx	Lung	RP11-973N13.4	0.10	0.04	lasso	5	0.05	8.3e-05	6.3	-5.9	3.3e-09	0.10	0.21	0.75	FALSE
24	GTEx	Muscle Skeletal	RP11-973N13.4	0.12	0.03	enet	39	0.03	3.8e-04	-5.7	-6.9	4.5e-12	0.07	0.05	0.94	FALSE
25	GTEx	Nerve Tibial	ZBTB25	0.10	0.04	lasso	5	0.02	2.1e-02	-5.0	-5.8	4.8e-09	0.02	0.03	0.83	FALSE
26	GTEx	Nerve Tibial	RHOJ	0.08	0.04	lasso	3	0.02	2.7e-02	7.5	-7.9	2.5e-15	-0.76	0.05	0.93	FALSE
27	GTEx	Nerve Tibial	HSPA2	0.10	0.01	enet	15	0.01	5.7e-02	4.9	-5.8	6.7e-09	0.07	0.26	0.44	FALSE
28	GTEx	Nerve Tibial	ZBTB1	0.22	0.15	lasso	8	0.15	6.2e-11	-5.5	-6.5	8.8e-11	0.04	0.24	0.76	FALSE
29	GTEx	Nerve Tibial	RP11-973N13.4	0.09	0.07	lasso	4	0.06	4.4e-05	5.5	-6.0	2.4e-09	0.06	0.06	0.93	FALSE
30	GTEx	Nerve Tibial	CTD-2555O16.4	0.09	0.06	lasso	6	0.04	7.7e-04	-7.1	-5.4	8.0e-08	-0.01	0.06	0.81	FALSE
31	GTEx	Ovary	CTD-2555O16.2	0.23	0.10	enet	26	0.18	2.7e-05	4.7	-5.6	2.0e-08	0.02	0.27	0.34	FALSE
32	GTEx	Pancreas	ZBTB1	0.10	0.15	lasso	2	0.11	3.1e-05	-5.7	-5.7	1.2e-08	0.03	0.36	0.29	FALSE
33	GTEx	Skin Sun Exposed Lower leg	RP11-973N13.4	0.20	0.11	lasso	7	0.19	6.4e-16	-5.5	-6.0	2.5e-09	0.05	0.73	0.27	FALSE
34	GTEx	Testis	RP11-973N13.4	0.29	0.36	lasso	4	0.36	1.1e-16	5.3	-5.5	4.9e-08	0.07	1.00	0.00	FALSE
35	GTEx	Thyroid	CTD-2555O16.2	0.09	0.03	enet	9	0.04	5.1e-04	4.0	-6.1	1.3e-09	0.03	0.39	0.49	FALSE
36	GTEx	Thyroid	RP11-973N13.4	0.16	0.05	lasso	4	0.06	4.8e-05	-5.0	-6.2	4.3e-10	-0.01	0.03	0.96	FALSE
37	GTEx	Thyroid	CTD-2555O16.4	0.10	0.05	enet	17	0.04	8.1e-04	4.7	-6.5	6.7e-11	0.00	0.40	0.54	FALSE
38	METSIM	Adipose	ESR2	0.03	0.02	enet	8	0.03	2.5e-05	-6.6	5.5	3.3e-08	0.04	0.50	0.45	FALSE
39	METSIM	Adipose	ZBTB25	0.04	0.05	lasso	7	0.04	3.1e-07	7.5	-7.5	9.5e-14	0.01	0.01	0.99	FALSE
40	NTR	Blood	ESR2	0.03	0.01	bslmm	507	0.01	5.5e-04	-6.1	-5.6	2.3e-08	-0.01	0.27	0.69	FALSE
41	NTR	Blood	SYNE2	0.08	0.08	lasso	5	0.08	9.9e-25	-6.5	6.9	4.3e-12	0.07	0.07	0.93	FALSE
42	YFS	Blood	ZBTB25	0.18	0.24	lasso	14	0.24	1.5e-78	6.4	-6.4	1.3e-10	0.01	0.88	0.12	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZBTB1	0.04	0.01	blup	56	0.03	1.2e-03	3.9	-6.5	7.0e-11	-0.03	0.01	0.59	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZBTB25	0.04	0.03	blup	64	0.03	3.1e-03	7.4	-6.9	6.0e-12	-0.01	0.01	0.94	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	RHOJ	0.03	0.01	blup	100	0.02	5.6e-05	7.7	-7.5	5.6e-14	-0.73	0.03	0.92	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZBTB25	0.03	0.04	blup	64	0.05	1.3e-09	6.5	-7.2	8.6e-13	0.01	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZBTB25	0.08	0.05	blup	64	0.05	2.2e-03	6.5	-6.9	3.9e-12	0.05	0.02	0.92	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ESR2	0.04	0.01	blup	88	0.03	1.1e-04	-7.0	-6.7	1.6e-11	-0.05	0.01	0.98	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSPA2	0.04	0.02	lasso	4	0.02	4.3e-03	5.3	-6.0	1.5e-09	0.09	0.09	0.46	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZBTB25	0.06	0.04	blup	64	0.05	9.9e-07	6.5	-6.0	1.8e-09	-0.02	0.04	0.96	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZBTB25	0.05	0.04	lasso	3	0.03	4.8e-03	6.4	-6.4	2.0e-10	0.02	0.04	0.69	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB1	0.04	0.03	blup	56	0.04	2.5e-05	7.3	-7.0	3.8e-12	0.03	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZBTB25	0.04	0.07	lasso	3	0.07	5.3e-08	5.8	-6.6	5.0e-11	0.01	0.03	0.97	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZBTB25	0.06	0.07	lasso	2	0.07	4.9e-04	6.4	-6.7	2.4e-11	0.00	0.05	0.82	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ESR2	0.02	0.00	blup	88	0.01	2.1e-02	6.9	-7.7	1.3e-14	-0.02	0.02	0.81	FALSE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB25	0.03	0.01	blup	64	0.02	4.5e-03	6.4	-5.8	6.3e-09	-0.02	0.03	0.40	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf50	0.04	0.02	blup	48	0.04	3.8e-05	7.4	6.7	2.1e-11	-0.06	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZBTB25	0.05	0.04	blup	64	0.06	1.2e-06	7.4	-7.0	3.2e-12	-0.01	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZBTB25	0.08	0.06	enet	10	0.09	5.6e-04	6.4	-6.4	1.5e-10	0.02	0.07	0.69	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	ESR2	0.05	0.05	lasso	3	0.05	9.6e-06	-6.5	-6.5	9.1e-11	-0.06	0.02	0.98	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	ZBTB1	0.03	0.04	enet	4	0.03	1.5e-03	-5.5	-6.3	2.4e-10	0.02	0.04	0.81	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	ZBTB25	0.10	0.09	blup	64	0.12	2.2e-11	6.5	-6.4	1.9e-10	0.03	0.07	0.93	FALSE