Best TWAS P=2.01e-12 · Best GWAS P=7.75e-23 conditioned to 0.0039
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TPM1 | 0.07 | 0.01 | bslmm | 523 | 0.02 | 3.3e-03 | 4.4 | 5.5 | 4.0e-08 | -0.25 | 0.27 | 0.27 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-244F12.3 | 0.15 | 0.00 | lasso | 5 | 0.00 | 2.2e-01 | 5.1 | 5.3 | 1.3e-07 | -0.09 | 0.18 | 0.05 | FALSE |
| 3 | GTEx | Artery Coronary | USP3-AS1 | 0.20 | 0.04 | lasso | 5 | 0.02 | 7.1e-02 | 3.3 | -5.7 | 9.5e-09 | 0.22 | 0.12 | 0.10 | TRUE |
| 4 | GTEx | Artery Tibial | FBXL22 | 0.05 | 0.03 | lasso | 4 | 0.03 | 1.2e-03 | 5.7 | -5.3 | 1.1e-07 | 0.68 | 0.49 | 0.03 | FALSE |
| 5 | GTEx | Brain Caudate basal ganglia | RP11-244F12.2 | 0.47 | 0.27 | lasso | 8 | 0.30 | 2.5e-09 | 5.5 | 5.2 | 2.5e-07 | -0.12 | 0.96 | 0.00 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | USP3 | 0.41 | 0.07 | lasso | 8 | 0.12 | 2.0e-04 | 7.1 | -7.0 | 2.0e-12 | 0.48 | 0.11 | 0.29 | TRUE |
| 7 | GTEx | Colon Transverse | USP3 | 0.11 | 0.02 | lasso | 5 | 0.04 | 6.1e-03 | 7.1 | -6.5 | 8.9e-11 | 0.52 | 0.18 | 0.06 | TRUE |
| 8 | GTEx | Heart Left Ventricle | FBXL22 | 0.07 | 0.08 | lasso | 4 | 0.05 | 8.8e-04 | 5.8 | -6.2 | 4.6e-10 | 0.72 | 0.18 | 0.54 | FALSE |
| 9 | GTEx | Heart Left Ventricle | USP3-AS1 | 0.14 | 0.04 | enet | 13 | 0.10 | 9.1e-06 | -2.8 | -5.4 | 7.3e-08 | 0.51 | 0.07 | 0.57 | FALSE |
| 10 | GTEx | Lung | TPM1 | 0.09 | 0.03 | lasso | 5 | 0.03 | 1.6e-03 | 5.5 | 5.6 | 2.0e-08 | -0.12 | 0.50 | 0.02 | FALSE |
| 11 | GTEx | Muscle Skeletal | FBXL22 | 0.08 | 0.09 | lasso | 3 | 0.09 | 3.2e-09 | 5.1 | -5.3 | 1.0e-07 | 0.69 | 1.00 | 0.00 | TRUE |
| 12 | METSIM | Adipose | HERC1 | 0.07 | 0.06 | lasso | 6 | 0.06 | 7.2e-10 | 5.8 | 5.9 | 3.0e-09 | -0.70 | 0.47 | 0.53 | FALSE |
| 13 | NTR | Blood | USP3 | 0.02 | 0.02 | enet | 4 | 0.02 | 5.4e-07 | 6.1 | 6.1 | 1.2e-09 | -0.68 | 0.25 | 0.75 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HERC1 | 0.03 | 0.00 | blup | 98 | 0.02 | 2.0e-03 | 4.8 | 6.3 | 2.3e-10 | -0.49 | 0.04 | 0.48 | FALSE |