[Hub]/) : Traits : Heel T-Score : ← →

chr15:64,829,830-68,789,191

Best TWAS P=2.42e-26 · Best GWAS P=5.78e-46 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AAGAB	0.06	0.05	enet	11	0.05	3.2e-07	5.94	6.3	3.4e-10	-0.15	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DENND4A	0.06	0.05	enet	18	0.05	7.1e-07	-9.50	-7.9	2.1e-15	-0.03	0.75	0.25	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IQCH	0.13	0.11	bslmm	597	0.10	5.9e-12	6.81	-5.7	1.2e-08	0.18	1.00	0.00	TRUE
4	CommonMind	Brain Pre-frontal Cortex	SLC24A1	0.05	0.03	lasso	7	0.03	3.0e-04	-9.54	-8.0	8.9e-16	-0.08	0.63	0.22	FALSE
5	GTEx	Adipose Visceral Omentum	PTPLAD1	0.13	0.10	enet	20	0.08	5.6e-05	-8.30	-8.4	3.4e-17	-0.07	0.27	0.58	FALSE
6	GTEx	Artery Tibial	DENND4A	0.05	0.01	enet	8	0.02	8.3e-03	-10.30	-10.4	1.5e-25	-0.08	0.07	0.81	FALSE
7	GTEx	Brain Cerebellar Hemisphere	IGDCC4	0.19	0.12	lasso	7	0.10	1.2e-03	-9.35	8.5	2.3e-17	0.08	0.33	0.31	FALSE
8	GTEx	Brain Cerebellum	IGDCC4	0.28	0.27	lasso	5	0.24	9.6e-08	-7.79	8.7	2.5e-18	0.08	0.57	0.32	FALSE
9	GTEx	Brain Cerebellum	MAP2K5	0.27	0.12	lasso	5	0.14	7.9e-05	6.83	-5.4	6.0e-08	0.11	0.49	0.03	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	DENND4A	0.16	0.09	lasso	4	0.06	8.8e-03	-10.46	-10.6	2.4e-26	-0.08	0.01	0.92	TRUE
11	GTEx	Cells EBV-transformed lymphocytes	PTPLAD1	0.18	0.18	enet	25	0.15	1.7e-05	-8.04	7.9	2.1e-15	0.08	0.29	0.65	FALSE
12	GTEx	Cells Transformed fibroblasts	DENND4A	0.08	0.06	lasso	2	0.04	3.3e-04	-9.35	9.3	8.8e-21	0.06	0.62	0.25	FALSE
13	GTEx	Muscle Skeletal	IGDCC4	0.03	0.01	lasso	2	0.02	9.2e-03	-8.45	7.3	3.2e-13	0.08	0.20	0.37	FALSE
14	GTEx	Muscle Skeletal	SMAD3	0.13	0.10	enet	8	0.10	4.2e-10	-7.44	-8.4	3.2e-17	0.09	1.00	0.00	TRUE
15	GTEx	Pituitary	DENND4A	0.19	0.12	enet	9	0.10	1.5e-03	-7.68	-8.5	2.1e-17	-0.07	0.13	0.42	FALSE
16	GTEx	Skin Sun Exposed Lower leg	IGDCC4	0.05	0.00	enet	9	0.00	6.1e-01	-8.16	6.6	4.4e-11	0.03	0.04	0.05	FALSE
17	GTEx	Testis	DPP8	0.09	0.03	lasso	3	0.04	5.3e-03	-2.98	5.5	2.9e-08	0.06	0.06	0.58	FALSE
18	GTEx	Whole Blood	MAP2K5	0.09	0.06	lasso	6	0.06	8.1e-06	3.19	-5.6	2.7e-08	0.11	0.84	0.00	TRUE
19	METSIM	Adipose	PARP16	0.03	0.01	bslmm	327	0.01	2.8e-03	0.66	6.9	4.6e-12	0.05	0.04	0.28	FALSE
20	METSIM	Adipose	SMAD3	0.09	0.01	lasso	4	0.01	4.1e-03	-8.43	6.5	8.7e-11	-0.55	0.02	0.91	TRUE
21	YFS	Blood	SLC24A1	0.06	0.02	bslmm	339	0.03	5.8e-10	-10.46	5.7	1.4e-08	0.09	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPP8	0.07	0.00	enet	9	0.03	2.9e-03	1.04	6.0	2.0e-09	0.05	0.01	0.80	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	6.31	-7.0	3.3e-12	0.22	0.18	0.81	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	DENND4A	0.01	0.01	blup	68	0.01	7.5e-03	-7.58	6.4	1.2e-10	0.04	0.03	0.16	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPP8	0.08	0.02	lasso	4	0.05	6.1e-10	-10.46	7.9	2.0e-15	0.05	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	6.97	-7.3	2.5e-13	0.23	0.07	0.93	TRUE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PTPLAD1	0.09	0.06	blup	46	0.06	5.2e-04	6.64	9.7	3.6e-22	0.08	0.05	0.52	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	6.36	-7.5	7.5e-14	0.21	0.16	0.67	TRUE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	DPP8	0.25	0.14	enet	6	0.12	1.8e-04	1.04	5.4	8.4e-08	0.04	0.01	0.73	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	IQCH	0.19	0.14	enet	21	0.12	2.4e-04	6.36	-6.7	1.6e-11	0.20	0.21	0.59	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IQCH	0.06	0.04	blup	111	0.03	1.0e-04	6.36	-6.2	6.3e-10	0.23	0.27	0.47	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PTPLAD1	0.05	0.01	enet	10	0.02	4.3e-03	0.67	5.9	4.5e-09	0.03	0.04	0.16	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPP8	0.03	0.01	blup	53	0.01	8.4e-03	-7.79	10.4	4.1e-25	0.09	0.01	0.86	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQCH	0.12	0.10	enet	22	0.12	4.0e-13	6.33	-7.0	2.4e-12	0.25	0.84	0.16	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	IQCH	0.05	0.04	blup	111	0.04	7.7e-06	6.31	-6.9	5.2e-12	0.25	0.15	0.83	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	DPP8	0.07	0.01	blup	53	0.03	1.7e-04	0.99	6.5	9.8e-11	0.05	0.02	0.91	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	IQCH	0.04	0.02	enet	8	0.01	1.6e-02	4.31	-5.1	2.9e-07	0.22	0.13	0.07	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IQCH	0.04	0.02	enet	6	0.03	1.6e-04	3.27	-6.2	7.8e-10	0.19	0.09	0.81	TRUE
39	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DENND4A	0.04	0.02	blup	67	0.02	1.3e-02	-10.19	9.1	7.7e-20	0.06	0.01	0.71	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IQCH	0.11	0.10	blup	112	0.10	2.3e-07	4.28	-6.7	2.2e-11	0.23	0.49	0.50	FALSE
41	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	6.31	-7.4	1.5e-13	0.21	0.14	0.72	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DPP8	0.08	0.04	blup	53	0.06	2.2e-03	-8.09	9.4	3.5e-21	0.08	0.06	0.42	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPP8	0.08	0.08	lasso	4	0.07	1.6e-07	-10.49	10.2	2.2e-24	0.09	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Rectum Adenocarcinoma	DENND4A	0.17	0.08	blup	68	0.07	1.0e-02	-10.19	10.3	1.2e-24	0.08	0.03	0.68	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	DPP8	0.16	0.01	blup	53	0.03	9.7e-03	1.09	6.3	2.7e-10	0.05	0.01	0.29	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	IQCH	0.08	0.09	enet	8	0.08	2.3e-05	6.36	-6.0	1.7e-09	0.18	0.59	0.20	TRUE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	6.31	-6.7	2.6e-11	0.21	0.07	0.34	FALSE
48	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DENND4A	0.09	0.05	lasso	4	0.03	3.3e-02	-9.35	9.1	1.3e-19	0.05	0.04	0.32	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	DPP8	0.05	0.02	lasso	5	0.04	5.9e-05	-10.49	9.7	3.4e-22	0.10	0.00	0.99	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	IQCH	0.15	0.17	enet	19	0.17	1.3e-16	6.33	-6.7	2.2e-11	0.22	0.77	0.23	TRUE