TWAS hub - USP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.2810	0.1120	4.0e-03	-0.009	NA	-0.006	NA	-0.008	9.7e-01	NA	6.2e-01	NA	7.5e-01
2	GTEx	Breast Mammary Tissue	0.2360	0.0660	3.3e-05	0.060	NA	0.075	NA	0.074	4.9e-04	NA	1.1e-04	NA	1.2e-04
3	GTEx	Breast Mammary Tissue (Female)	0.4068	0.1095	3.8e-04	0.075	NA	0.117	NA	0.120	3.0e-03	NA	2.4e-04	NA	2.0e-04
4	GTEx	Colon Transverse	0.1060	0.0550	8.1e-03	0.017	NA	0.009	NA	0.039	4.9e-02	NA	1.1e-01	NA	6.1e-03
5	GTEx	Thyroid	0.0870	0.0410	2.8e-03	0.000	NA	0.016	NA	0.004	3.1e-01	NA	2.0e-02	NA	1.4e-01
6	NTR	Blood	0.0195	0.0086	2.2e-03	0.024	0.012	0.019	0.015	0.019	3.2e-08	6.7e-05	5.4e-07	1.1e-05	5.4e-07
7	TCGA	Brain Lower Grade Glioma	0.0899	0.0472	2.7e-03	0.005	0.021	0.016	NA	0.011	7.4e-02	1.6e-03	5.8e-03	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Severe depression (siblings)	5.8	6.4	14.9	-1.2	2.3	3.9	3.2	-2.8	1.9	1.3
Ever had stillbirth, spontaneous miscarriage or termination	5.1	5.4	13.4	1.0	-2.5	-3.7	-3.4	0.6	-0.2	-2.4
Crohns Disease (2017)	5.0	11.1	22.2	1.9	4.7	3.8	3.8	-4.1	1.6	-1.9
Exposure to tobacco smoke outside home	4.8	6.4	13.0	-1.1	-3.2	-3.6	-3.4	2.4	1.0	1.2
Crohns Disease (2012)	4.4	7.0	21.1	0.0	4.6	3.4	3.1	-2.1	0.7	-1.4
Mouth/teeth dental problems: Dentures	4.4	7.5	16.8	-1.2	0.8	2.7	2.5	-2.3	4.1	3.8
Birth weight	4.2	9.2	16.6	1.9	3.7	4.1	3.7	0.6	4.0	0.2
Lung FEV1/FVC ratio	3.9	19.6	40.7	-2.7	2.5	6.4	4.8	-2.0	4.0	6.3
Irritable Bowel Disease (IBD)	3.8	9.1	18.5	2.1	4.3	3.8	3.6	-2.8	2.0	-1.2
Breast Cancer	3.7	8.9	26.9	1.2	-5.2	-4.2	-3.9	0.5	-0.2	-0.8
Fasting Glucose	3.7	4.5	9.0	-2.9	-2.4	-2.5	-3.0	-0.4	0.2	0.9
Medication: Metformin	3.3	4.6	8.6	-1.2	-2.7	-2.9	-2.7	1.1	-0.4	2.5
Relative age of first facial hair	3.2	6.5	24.3	2.0	1.5	2.5	2.9	0.1	4.9	-0.8
Asthma (self-reported)	3.2	6.3	13.7	-0.5	-2.7	-3.7	-3.4	1.5	-2.9	0.9
Asthma	3.1	6.1	12.7	-0.3	-2.8	-3.6	-3.2	1.4	-3.0	0.7
Commuting to job workplace: Public transport	3.1	3.7	8.1	-0.9	-1.8	-2.6	-2.9	1.3	-0.6	2.2
Heel T-Score	3.0	24.2	49.4	-1.6	-4.4	-7.0	-6.5	-2.8	6.1	-3.4
Triglycerides	2.7	4.5	8.4	-2.2	-0.9	-2.2	-2.6	-0.6	2.9	2.2
Hearing difficulty/problems with background noise	2.7	4.3	9.7	0.2	-1.7	-2.9	-3.1	1.5	-2.5	0.8
Medication: Seretide 50 evohaler	2.7	3.1	10.2	1.2	-3.2	-2.3	-1.6	-0.1	-1.5	-0.1
Respiratory disease	2.6	5.8	12.6	-0.7	-3.1	-3.5	-3.1	1.5	-1.7	1.8
Hearing difficulty/problems: Yes	2.6	3.9	7.7	-1.4	-2.8	-2.4	-2.3	1.1	-1.2	2.0
Prospective memory result	2.6	3.2	8.4	-1.7	1.5	2.3	2.9	-0.7	1.5	-1.0
Supplements: Vitamin C	2.6	3.1	8.5	-1.3	-2.9	-1.9	-2.6	-0.4	-0.2	1.1
Type 2 Diabetes (T2D) (2012)	2.4	2.8	6.3	-1.4	-1.4	-1.9	-2.5	1.4	0.3	1.8
Taking other prescription medications	2.4	3.8	6.4	-0.8	-2.0	-2.5	-2.5	0.5	-2.2	2.0
Medication: Ventolin 100micrograms inhaler	2.4	3.0	6.4	0.5	-2.1	-2.1	-2.0	1.2	-2.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	6.6	-0.6	1.9	2.6	2.4	0.4	1.5	1.0
Type 2 Diabetes (T2D) (2018)	2.3	4.3	11.1	-1.0	-1.8	-2.8	-3.3	1.8	-1.0	1.7
Mouth/teeth dental problems	2.3	3.5	6.9	0.2	-1.7	-2.3	-2.0	0.8	-2.6	-2.1
Exposure to tobacco smoke at home	2.3	2.6	5.5	-1.2	-1.9	-2.3	-1.8	-0.1	-2.0	-0.6
Medication: Co-codamol	2.2	2.5	6.5	-0.7	2.2	1.2	1.6	-0.8	2.5	0.7
Blood clot in the leg (DVT)	2.2	2.8	5.9	-1.5	-1.7	-2.3	-2.4	1.3	-1.0	0.6
Diabetes diagnosed by doctor	2.2	3.6	7.7	-1.1	-1.1	-2.1	-2.8	1.7	-1.6	2.2
Major Depression (MDD)	2.1	2.6	4.9	0.1	-2.2	-1.6	-1.6	1.6	1.6	1.7
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	13.8	-1.0	0.5	0.8	0.0	3.2	3.7	1.9
Illnesses of father: None of the above (group 1)	2.1	2.6	6.7	-0.6	2.4	2.6	2.2	0.4	0.2	0.1
Miserableness	2.1	3.7	13.1	-2.4	-0.5	0.8	0.4	1.1	3.6	2.1
Allergy	2.0	4.6	9.3	0.3	3.1	2.7	2.8	-1.6	2.3	-0.1
Medication: Lansoprazole	2.0	2.2	5.7	-0.3	1.1	2.2	2.4	-0.0	-1.9	-0.4
Hair/balding pattern: Pattern 4	2.0	4.9	8.3	0.1	-2.6	-2.8	-2.8	0.5	-2.9	-1.8
Number of children fathered	2.0	2.3	6.4	0.3	1.7	2.1	2.5	-1.4	0.0	-0.3
Tinnitus: Yes, now most or all of the time	2.0	2.3	4.1	0.8	-1.8	-1.9	-1.8	1.2	-2.0	-0.1
Coronary Artery Disease (CAD)	1.9	2.2	8.3	-0.5	-1.3	-2.2	-2.9	-0.0	-0.4	-0.4
Ever used hormone-replacement therapy (HRT)	1.9	2.4	6.3	0.0	-2.5	-2.2	-2.0	0.3	-0.6	1.2
Vitamin and mineral supplements	1.9	2.6	6.8	-0.1	2.6	1.8	2.0	-1.2	1.8	-0.1
Hand grip strength (right)	1.9	5.1	12.5	-0.3	2.4	3.1	3.5	-2.0	1.5	-1.0
Diabetes (self-reported)	1.9	3.0	5.3	-0.9	-0.9	-1.8	-2.3	2.2	-1.5	1.9
Wheeze or whistling in the chest in last year	1.9	3.3	7.7	0.4	-2.8	-2.1	-1.6	2.2	-1.6	0.9
Illnesses of father: Heart disease	1.9	2.6	6.1	1.4	-1.6	-2.2	-2.5	-1.2	-0.5	1.1
Alcohol drinker status: Previous	1.9	2.1	5.8	-1.7	-0.2	0.1	-0.6	2.4	0.5	2.4
Alzheimer’s Disease (in father)	1.8	2.0	5.3	-0.9	-2.3	-1.0	-0.2	1.1	1.0	2.1
BMI	1.8	10.2	32.2	-0.0	-3.1	-4.1	-3.3	0.4	-5.7	1.5
Diabetes (father)	1.8	2.2	7.5	-0.0	-2.7	-1.7	-1.7	0.3	0.8	1.2
Pulse rate	1.8	3.1	7.6	-2.0	0.7	1.7	1.6	1.5	1.2	2.8
Mood swings	1.8	3.2	5.1	-1.9	2.2	2.3	1.2	0.8	1.7	1.9
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.0	-1.3	-1.6	-2.1	-2.2	1.2	-0.8	0.8
Alzheimer’s Disease (including proxy)	1.7	2.5	9.2	0.1	-3.0	-0.7	-0.4	2.3	1.4	0.6
Waist Hip Ratio (WHR)	1.7	7.7	21.1	-0.4	-2.8	-1.3	-2.0	1.9	4.6	3.9
Sitting height	1.7	11.9	49.4	1.8	-1.8	-2.2	-2.3	2.5	7.0	3.2
Ever had bowel cancer screening	1.7	2.0	4.2	-0.1	2.0	1.7	1.3	-1.0	0.3	-2.0
Average weekly champagne plus white wine intake	1.7	2.3	8.8	3.0	0.4	-0.4	-0.2	1.8	-0.3	-1.9
Hearing aid user	1.7	1.9	3.1	-1.8	-1.3	-1.2	-1.7	0.6	1.6	1.0
Irritability	1.7	3.0	4.8	0.2	1.5	2.2	2.0	1.5	1.8	2.1
Body Mass Index (BMI) (2010)	1.6	2.2	7.1	-0.9	-1.2	-1.6	-1.5	-1.1	-2.7	0.2
Ulcerative Colitis	1.6	2.3	5.0	1.4	2.2	2.2	1.8	-0.7	0.9	-0.3
Average weekly spirits intake	1.6	2.0	5.8	0.1	-2.4	-1.7	-1.7	0.7	-1.2	-0.6
Townsend deprivation index at recruitment	1.6	2.2	11.8	-1.2	-1.4	-0.3	-0.4	0.1	-0.1	3.4
Medication: Levothyroxine sodium	1.6	2.6	6.7	-2.6	0.7	0.7	0.7	2.2	1.6	1.7
Qualifications: None of the above	1.6	3.3	6.1	-2.2	1.0	2.3	2.5	-2.1	0.9	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	5.0	-0.9	0.6	2.1	1.4	0.4	2.2	2.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	6.4	-1.1	-1.0	-0.6	-0.1	-2.5	-1.3	1.6
Commuting to job workplace: Car/motor vehicle	1.6	1.8	5.4	0.1	2.3	1.3	1.0	0.2	2.1	-0.2
Bipolar Disorder (2018)	1.5	2.3	4.5	-0.2	2.1	2.1	1.6	1.6	1.5	0.3
Ulcerative Colitis (UC)	1.5	2.7	5.6	1.7	2.2	2.4	2.0	0.2	1.2	-0.6
Systolic blood pressure, automated reading	1.5	4.5	16.5	-2.6	2.2	0.0	-0.3	-4.1	1.1	1.3
Tense / ‘highly strung’	1.5	2.5	5.8	0.4	1.6	2.4	2.3	-0.4	1.2	1.4
Chest pain or discomfort	1.5	2.2	10.4	-3.2	-1.1	-1.0	-0.9	-0.9	-1.2	-0.0
Commuting to job workplace: Cycle	1.5	1.8	4.1	-1.6	-1.6	-2.0	-1.3	1.2	-0.7	-0.4
Heart disease (siblings)	1.5	1.8	6.5	-1.3	0.5	0.5	-0.2	1.7	1.1	2.6
Ovarian Cancer	1.4	1.9	5.2	0.5	-1.8	-2.3	-2.0	-0.2	-0.7	-0.1
LDL Cholesterol	1.4	2.2	5.7	1.1	1.6	0.8	1.4	-0.7	2.4	-1.6
Medication for hormone replacement therapy	1.4	1.5	3.1	0.2	-1.8	-1.4	-1.5	0.5	1.6	0.7
Depression (self-reported)	1.4	1.7	4.3	1.1	0.8	1.9	2.1	0.7	-0.8	1.0
Family relationship satisfaction	1.4	1.7	4.0	-1.6	-0.9	-0.8	-1.5	-2.0	-0.4	1.3
Breast cancer (self-reported)	1.4	1.6	4.2	0.9	1.6	0.2	0.4	0.3	-2.1	-1.9
Pain type(s) experienced in last month: Hip pain	1.4	1.7	4.6	-2.1	0.7	0.0	-0.2	1.6	-0.3	2.0
Diastolic blood pressure, automated reading	1.4	4.3	6.3	-2.0	2.4	1.2	1.0	-2.4	2.3	2.5
Alzheimer’s Disease (in mother)	1.3	1.6	3.7	0.4	-1.9	-1.3	-1.4	1.5	-0.1	-1.1
Bipolar Disorder (2011)	1.3	1.3	3.7	-0.8	1.6	1.9	1.0	0.7	0.5	0.3
Neuroticism (2016)	1.3	1.8	6.3	0.0	0.9	0.8	0.1	1.2	2.5	1.9
Systolic Blood Pressure	1.3	6.6	25.0	-2.4	0.4	-1.0	-1.3	-5.0	3.4	1.2
Neuroticism	1.3	3.1	5.5	0.3	2.0	2.2	2.0	0.7	2.3	1.9
Sensitivity / hurt feelings	1.3	2.2	3.7	-1.9	1.4	1.9	1.4	0.1	1.5	1.3
Supplements: Zinc	1.3	1.4	4.0	0.5	-2.0	-1.6	-1.3	0.9	-0.8	0.2
Relative age voice broke	1.3	2.0	7.1	1.7	0.1	0.7	1.1	1.4	2.7	-0.5
Multivitamins +/- minerals	1.3	1.6	4.8	-0.1	-1.4	-0.8	-0.5	2.2	-1.8	-0.8
Body mass index (BMI)	1.3	5.4	30.3	0.6	-1.0	-1.8	-1.0	-0.7	-5.5	1.1
Medication: Simvastatin	1.3	1.9	6.1	-0.9	1.2	0.9	0.5	-0.4	1.8	2.5
Heart disease (mother)	1.3	1.6	4.2	-1.8	0.6	1.2	0.7	-1.1	0.0	2.1
Illnesses of siblings: Diabetes	1.3	1.6	4.0	-0.8	-1.4	-1.6	-2.0	1.2	-0.5	0.7
Medication: Gliclazide	1.3	1.5	3.3	-0.6	-0.9	-1.8	-1.8	0.2	0.0	1.7
Mother’s age at death	1.3	1.6	4.2	1.7	-0.8	-0.7	-0.5	-0.0	-2.0	-1.7
Financial situation satisfaction	1.3	1.6	4.2	-2.0	-1.7	-1.6	-1.2	-0.1	-0.4	-0.6
Risk taking	1.3	1.9	7.4	-0.0	-1.9	-0.9	-1.0	0.6	-0.1	2.7
Intelligence (Savage-Jansen 2018)	1.2	3.6	12.8	-0.4	0.2	1.3	0.6	-1.3	2.9	3.6
Schizophrenia vs Biploar Disorder	1.2	1.6	5.1	0.1	-0.4	0.0	0.5	-1.8	-1.6	-2.3
Hypothyroidism (self reported)	1.2	2.6	5.4	-1.7	-0.5	-1.6	-1.5	2.3	1.8	1.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	4.0	0.1	-0.5	-1.4	-1.3	1.2	-2.0	-0.6
Serious illness, injury or assault to yourself	1.2	1.4	5.4	-2.3	-0.5	-0.5	-0.6	-0.4	1.0	1.6
Hair/balding pattern: Pattern 2	1.2	1.5	4.4	-0.1	1.3	1.4	1.3	1.1	2.1	0.4
Falls in the last year	1.2	1.7	2.3	1.5	-1.5	-1.5	-1.4	0.4	-1.4	-1.0
Number of live births	1.2	1.7	5.1	-1.2	-1.9	-0.5	-0.2	-2.3	-1.1	0.6
Peak expiratory flow (PEF)	1.2	2.9	5.4	-1.0	-1.7	-1.5	-1.6	2.3	1.1	2.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.6	-2.1	-0.5	-0.5	-0.7	1.8	2.1	2.0
Pulse rate, automated reading	1.2	4.0	8.6	-0.2	0.7	2.5	2.9	0.8	1.8	2.9
Number of full sisters	1.2	1.5	2.6	-1.6	-1.3	-1.2	-1.2	-0.2	1.1	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.3	2.3	1.0	0.5	0.7	-1.1	0.9	-1.3
Handedness (chirality/laterality): Left-handed	1.2	1.5	4.1	-0.6	1.2	0.5	-0.5	2.0	1.1	1.5
Back pain experienced in last month	1.2	1.8	4.3	0.0	-2.0	-1.5	-0.9	0.6	-2.1	-0.9
Osteoarthritis (self-reported)	1.2	1.5	7.6	0.3	0.4	0.6	0.9	-1.0	-2.7	-0.6
Pack years of smoking	1.2	1.8	5.5	-0.6	0.9	1.7	2.4	-1.6	0.3	0.7
Depression (Nagel 2018)	1.1	1.6	5.0	-1.2	0.4	-0.8	-1.3	2.2	-0.8	1.5
Age at First Birth	1.1	1.6	5.0	0.6	2.2	1.4	0.8	-0.8	0.0	-1.5
HbA1C	1.1	1.2	4.5	-2.1	-1.1	-0.0	-1.0	0.7	0.6	1.0
HDL Cholesterol	1.1	1.9	6.0	1.3	-0.8	-0.1	0.8	2.5	-1.3	-1.5
Rheumatoid Arthritis	1.1	1.5	4.9	-0.1	0.4	1.0	0.8	2.2	1.8	0.9
Pack years adult smoking proportion	1.1	1.7	5.4	-0.8	1.0	1.8	2.3	-1.1	0.3	0.6
Supplements: Glucosamine	1.1	1.4	4.5	0.1	-0.6	-0.4	0.1	0.8	-2.1	-2.1
High blood pressure (mother)	1.1	1.6	2.9	-1.2	1.0	1.5	0.9	-1.7	1.7	0.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.2	1.0	-0.8	-0.7	-1.1	1.6	-2.1	-0.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.9	-2.2	-1.0	-0.8	-1.0	-1.0	0.4	-0.1
Loud music exposure frequency	1.1	1.2	3.6	1.1	0.1	-0.2	0.3	1.9	-1.8	-0.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.6	0.7	-0.5	-0.3	0.1	1.5	-1.6	-2.6
Worry too long after embarrassment	1.1	1.9	5.2	1.2	1.7	1.3	1.0	0.2	2.3	1.0
Neck or shoulder pain in last month	1.1	1.5	7.3	-2.7	0.3	-0.5	-1.0	0.7	0.6	1.1
Medication: Blood pressure	1.1	2.0	6.2	-1.1	1.2	0.6	0.2	-1.5	1.6	2.5
Medication: Allopurinol	1.1	1.5	5.5	-1.2	-0.8	-0.6	-0.8	2.3	-0.8	1.0
Alcohol intake frequency.	1.1	2.7	6.1	-2.0	1.6	2.5	2.1	-1.1	-0.1	0.1
Long-standing illness, disability or infirmity	1.1	1.6	3.5	-1.3	-1.1	-1.2	-1.0	0.1	-1.6	1.9
Osteoporosis (self-reported)	1.1	1.4	3.9	0.3	1.3	1.0	1.0	-1.0	-2.0	-0.9
Ever had prostate specific antigen (PSA) test	1.1	1.2	5.5	2.3	0.5	-0.1	0.1	1.3	-0.5	-1.0
Myopia	1.1	1.6	5.2	-0.2	0.2	1.3	0.9	-0.0	2.3	1.9
Pain experienced in last month	1.1	1.8	9.0	3.0	0.5	0.8	0.6	1.1	0.9	-0.5
Blood Eosinophil Count	1.0	7.5	31.7	0.4	-1.1	-2.2	-2.9	1.3	-5.6	2.2
Blood Platelet Count	1.0	11.0	66.5	2.4	-1.6	0.8	0.2	8.2	1.1	-0.6
Diabetes (mother)	1.0	1.2	2.6	0.8	-1.2	-1.4	-1.6	1.0	-0.2	1.0
Past tobacco smoking	1.0	1.8	4.7	0.5	0.2	-0.9	-0.3	-1.4	-2.1	-2.2
Medication: Ramipril	1.0	1.2	3.3	1.8	0.9	0.7	0.8	0.4	-0.4	1.8
Neuroticism score	1.0	2.1	3.5	-0.1	1.3	1.8	1.5	1.5	1.4	1.9
Arm fat percentage (right)	1.0	3.9	22.5	1.8	0.1	-0.9	0.0	-0.3	-4.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	8.5	0.9	0.6	0.9	-0.1	2.9	2.7	2.1
Leg fat percentage (right)	1.0	3.5	13.1	-0.0	-1.4	-2.4	-1.3	-1.1	-3.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	4.3	0.0	0.9	1.3	1.2	0.1	0.7	2.1
Arm fat percentage (left)	1.0	4.0	23.3	1.6	-0.1	-1.2	-0.3	-0.3	-4.8	0.6
Eye problems/disorders: Cataract	1.0	1.1	3.3	0.8	1.8	1.3	1.3	-0.7	-0.1	-0.0
Wears glasses or contact lenses	1.0	1.1	3.5	0.5	-0.0	0.9	1.1	-0.8	-1.9	1.2
High cholesterol (Self-reported)	1.0	1.8	4.9	-0.4	2.0	1.1	0.6	-1.4	2.2	0.3
Medication: Paracetamol	1.0	1.5	7.5	-2.7	-0.8	-0.7	-0.4	0.2	-1.3	0.1
Medication: Atorvastatin	1.0	1.3	6.3	0.3	2.5	0.3	0.3	0.0	1.1	-1.1
Leg fat percentage (left)	1.0	3.5	11.9	0.2	-1.4	-2.4	-1.5	-1.0	-3.5	1.3
Age started oral contraceptive pill	1.0	1.3	3.6	0.7	0.9	1.4	1.2	-1.9	0.5	-0.7
Cholesterol lowering medication	1.0	1.5	5.1	-0.4	2.2	0.8	0.9	-1.3	1.2	0.8
Depressed Affect (Nagel 2018)	0.9	1.9	5.3	-1.8	0.1	0.0	-0.3	1.3	1.8	2.3
Neuroticism (Nagel 2018)	0.9	2.2	8.3	-0.3	1.0	1.2	1.1	0.9	2.9	1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.3	7.7	-0.1	1.1	0.9	0.1	-0.4	2.8	2.4
Hand grip strength (left)	0.9	2.5	6.1	-0.2	1.2	1.9	2.5	-2.4	0.1	-0.7
Number of treatments/medications taken	0.9	1.6	2.8	-1.5	-1.2	-1.5	-1.5	-0.4	-0.3	1.7
Frequency of depressed mood in last 2 weeks	0.9	1.3	6.8	-0.5	1.0	0.7	0.4	2.6	0.1	0.4
Maternal smoking around birth	0.9	1.3	5.4	-1.0	-1.0	-0.7	-0.1	2.3	-0.8	0.6
Fed-up feelings	0.9	1.6	3.8	-1.1	1.1	1.1	0.7	1.3	1.2	2.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.5	0.1	1.0	1.9	1.4	0.4	-0.4	-0.6
Impedance of leg (left)	0.9	4.4	24.5	-1.6	-0.8	-1.1	-1.3	-0.2	5.0	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	2.8	-1.6	-1.2	0.6	0.7	-0.5	-0.3	1.7
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	9.5	-0.0	0.4	1.2	0.6	3.1	2.5	1.8
Medication: Cholesterol lowering	0.9	1.5	4.4	-0.3	1.0	0.8	0.1	-0.2	2.0	2.1
Standing height	0.9	8.5	44.8	0.7	1.2	1.2	1.0	2.5	6.7	2.0
Birth weight of first child	0.9	1.6	5.7	-1.4	0.5	0.8	-0.0	0.8	2.4	1.4
Glaucoma (self-reported)	0.9	1.1	3.4	1.6	-0.8	-0.2	0.1	-0.7	0.5	1.9
Number of full brothers	0.9	1.2	3.5	-0.8	0.4	0.9	0.3	1.0	1.4	1.9
Shortness of breath walking on level ground	0.9	1.1	2.8	-0.9	1.0	0.2	0.9	-1.7	1.5	-0.4
Medication: Omeprazole	0.9	1.0	4.0	-0.8	2.0	0.6	0.3	0.6	-1.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.2	-1.6	0.9	0.3	0.6	-0.4	-1.8	-0.5
Smoking status: Previous	0.9	1.3	5.2	-0.8	-0.1	0.6	0.4	0.7	2.3	1.5
Friendships satisfaction	0.9	1.1	4.5	-1.1	1.1	0.6	0.1	-2.1	0.2	0.6
Medication: Lisinopril	0.9	1.1	2.3	-1.2	1.5	0.7	0.4	1.2	0.9	1.1
Reaction Time	0.8	1.6	5.8	0.8	1.2	0.8	0.9	1.1	-0.6	-2.4
Mean Putamen Volume	0.8	0.9	2.3	-0.2	0.8	1.4	1.5	-0.2	-1.2	-0.1
Allergy or Eczema	0.8	2.1	6.5	0.3	-1.8	-1.3	-1.6	2.5	-0.6	0.4
Cardiovascular Disease	0.8	2.7	9.6	-1.2	0.5	-0.7	-0.4	-2.5	3.1	1.1
Impedance of leg (right)	0.8	4.1	22.4	-1.8	-1.0	-0.9	-1.0	-0.4	4.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	7.8	-1.3	-0.1	-0.9	-0.9	-1.2	2.8	-0.4
Qualifications: CSEs or equivalent	0.8	1.0	3.5	-0.5	-1.9	-1.2	-0.6	-1.0	0.7	0.1
Medication: Atenolol	0.8	1.0	3.8	-0.8	0.1	-0.2	-1.1	-1.1	0.3	2.0
Chronic bronchitis/emphysema (father)	0.8	1.0	1.7	-1.3	-0.4	0.9	1.1	-1.1	0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	5.8	-1.3	-0.3	-0.6	-0.4	-2.0	2.4	-0.7
Alcohol intake versus 10 years previously	0.8	1.2	3.1	-1.8	-1.1	-1.1	-0.9	0.2	-1.4	-0.1
Medication: Paracetamol	0.8	1.3	7.3	-2.7	-0.5	-0.0	0.4	-0.8	-0.8	-0.3
Health satisfaction	0.8	1.0	3.3	-1.8	0.6	0.8	0.5	-0.4	-0.3	1.4
Qualifications: College or University degree	0.8	2.4	4.2	2.0	-1.2	-1.4	-2.1	1.6	-1.4	1.1
Suffer from ‘nerves’	0.8	1.3	3.7	-0.7	-1.9	-1.3	-0.9	-1.2	0.7	0.3
Fractured/broken bones in last 5 years	0.8	1.1	2.0	1.4	-1.3	-1.4	-0.9	0.3	-1.0	-0.6
Height	0.7	12.6	68.4	-0.6	1.7	1.7	1.5	2.2	8.3	2.6
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	0.1	1.4	0.7	0.3	0.1	1.4	1.2
Angina	0.7	0.9	1.6	-0.4	0.9	1.1	1.3	-1.2	0.4	0.7
Waist circumference	0.7	2.7	6.3	-0.1	-1.0	-1.9	-1.6	0.6	-2.2	2.5
Had other major operations	0.7	0.9	3.1	0.3	0.3	-1.1	-1.0	0.1	-1.8	-0.9
Forced vital capacity (FVC)	0.7	2.7	15.2	0.9	0.3	-0.1	-0.3	3.9	1.6	0.5
Pain all over the body in last month	0.7	0.7	1.8	-0.9	-1.3	-1.1	-1.1	0.1	0.1	0.3
Fluid intelligence score	0.7	1.4	6.4	-0.5	0.9	-0.2	-1.1	0.2	2.5	1.0
Hip circumference	0.7	2.8	13.5	-0.5	-0.0	-1.7	-1.1	-0.3	-3.7	1.4
Time employed in main current job	0.7	0.8	3.4	0.7	0.8	0.6	0.9	-0.1	-0.4	-1.8
Arm fat mass (right)	0.7	2.8	14.5	1.5	-0.3	-1.1	-0.2	0.1	-3.8	1.1
Breastfed as a baby	0.7	0.8	2.4	-0.5	1.6	0.7	-0.1	-0.8	0.5	1.2
Forced vital capacity (FVC), Best measure	0.7	2.6	9.5	1.1	0.9	0.3	-0.4	3.1	2.4	0.9
Body fat percentage	0.7	2.8	13.5	1.1	-0.4	-1.7	-0.8	-0.4	-3.7	1.0
Age at first live birth	0.7	1.2	6.5	2.5	1.2	0.3	0.1	0.4	0.4	-0.4
Eye problems/disorders: None of the above	0.7	0.8	1.8	-0.2	-0.8	-0.9	-1.1	0.8	1.3	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.1	5.4	2.3	0.3	-0.4	-0.4	0.8	0.7	-1.1
Migraine (self-reported)	0.7	0.9	2.4	1.1	0.8	0.8	0.8	-0.7	0.4	-1.5
Medication: Ibuprofen	0.7	0.9	1.7	0.3	-0.9	-1.0	-0.9	1.2	-1.3	0.5
Overall health rating	0.7	1.5	6.3	-2.5	0.9	0.5	0.3	-0.6	-0.3	1.7
Commuting to job workplace: Walk	0.7	0.7	1.4	-0.8	-1.2	-0.8	-0.9	0.1	-1.2	0.2
Arm fat mass (left)	0.7	2.8	15.4	1.4	-0.2	-1.1	-0.3	0.2	-3.9	0.7
Number of self-reported non-cancer illnesses	0.7	1.3	7.0	-0.8	-0.1	0.3	-0.4	0.2	-1.0	2.6
Average weekly beer plus cider intake	0.7	1.0	3.6	-0.8	-0.8	-0.2	-0.3	-1.9	1.0	0.9
Bipolar Disorder or Schizophrenia	0.6	1.6	4.0	0.0	2.0	2.0	1.3	-0.3	1.0	-0.6
Prostate Cancer	0.6	0.8	5.0	-0.2	2.2	-0.0	-0.4	0.6	0.1	-0.1
Lupus	0.6	0.9	1.8	1.3	0.2	1.2	1.3	-0.4	0.1	1.2
Smoking Status	0.6	1.4	3.8	-0.5	0.1	1.9	1.7	1.0	0.8	1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-1.2	0.1	0.9	0.5	-1.4	-0.1	0.6
Alcohol usually taken with meals	0.6	1.0	4.6	-0.0	0.1	-0.7	-0.4	0.1	-1.3	-2.1
Financial difficulties in last 2 years	0.6	0.8	2.9	-1.2	-0.5	-0.1	0.3	0.7	-0.6	1.7
Heart attack	0.6	0.7	1.5	-1.0	1.1	0.4	0.1	-0.8	0.7	1.2
Father’s age at death	0.6	0.8	2.6	0.2	0.3	-1.0	-1.3	1.6	-0.2	0.5
Pulse wave reflection index	0.6	0.8	1.8	0.2	-0.2	-1.1	-1.3	-1.2	0.1	-0.8
Comparative body size at age 10	0.6	1.5	7.6	0.4	-1.3	0.2	-0.1	1.0	-2.8	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.0	1.4	-0.2	0.4	0.6	-0.5	1.0	1.1
Emphysema/chronic bronchitis	0.6	0.6	1.4	-1.2	-0.4	0.8	1.1	-0.6	0.8	0.3
Angina (self-reported)	0.6	0.7	1.5	-0.5	0.6	0.9	1.1	-1.2	0.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.5	-0.3	-0.6	-0.5	-0.1	-1.6	-1.0	-0.7
Leg fat mass (right)	0.6	2.2	8.6	0.6	-0.8	-1.6	-0.8	-0.5	-2.9	1.6
Comparative height size at age 10	0.6	3.5	13.8	-0.3	1.1	1.3	1.3	2.0	3.7	1.4
Hypertension (Self-reported)	0.6	1.6	3.0	-1.5	1.1	0.1	-0.1	-1.3	1.7	1.7
Mineral and other dietary supplements	0.6	0.8	2.7	-0.4	0.6	0.3	-0.7	-1.0	0.7	1.6
Illnesses of father: High blood pressure	0.6	0.8	1.6	-0.1	-0.5	-0.9	-1.0	-0.9	1.3	1.0
Ever smoked	0.6	1.1	3.5	0.1	-0.2	0.6	0.2	1.9	1.3	1.4
Unable to work because of sickness or disability	0.6	0.7	3.2	-0.2	1.8	0.8	0.8	-0.4	-0.5	-0.1
Primary Biliary Cirrhosis	0.5	0.7	1.3	1.1	0.9	0.8	0.8	-1.1	0.2	0.0
Blood Red Count	0.5	4.9	19.7	-1.3	-0.5	-1.0	-2.5	-1.6	4.4	1.9
Blood White Count	0.5	3.5	9.9	-1.3	3.1	1.3	0.4	0.3	2.6	2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	-0.3	0.9	1.0	0.9	-0.6	0.1	1.1
Trunk fat percentage	0.5	2.1	9.8	1.2	-0.1	-1.4	-0.5	-0.4	-3.1	1.0
Current tobacco smoking	0.5	0.8	1.6	0.2	0.0	1.1	1.1	0.5	-1.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.9	-1.2	1.4	0.6	0.3	0.0	-0.6	0.1
High blood pressure	0.5	1.3	3.6	-1.1	1.0	-0.0	-0.2	-0.9	1.9	1.6
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.5	-0.1	1.2	0.9	0.6	1.4	1.6	0.2
Illnesses of mother	0.5	0.6	2.1	1.4	0.2	-0.2	-0.1	0.9	-0.3	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	1.0	1.0	0.3	-0.1	0.3	-0.5	-1.3
Gout (self-reported)	0.5	0.7	1.4	-1.0	-0.9	-0.9	-1.2	-0.2	-0.7	0.6
Whole body fat mass	0.5	2.1	8.9	1.0	-0.3	-1.3	-0.5	-0.2	-3.0	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	0.1	-0.8	-1.1	-0.6	0.7	-0.2	1.2
Knee pain experienced in last month	0.5	0.8	3.4	-0.5	-0.4	-0.4	-0.3	-0.1	-1.2	1.9
Average weekly red wine intake	0.5	0.8	2.6	0.8	-0.7	-0.9	-1.0	0.1	0.3	-1.6
Qualifications: nursing, teaching	0.5	0.7	2.3	1.3	0.5	0.5	0.2	1.5	0.5	-0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.0	-0.2	0.1	0.6	1.4	0.6	0.2	-1.2
Alcohol drinker status: Never	0.5	0.6	1.7	-0.4	0.4	1.3	1.2	0.5	-0.7	0.2
Ever depressed for a whole week	0.5	0.6	2.7	-0.6	-1.6	-0.0	-0.6	0.6	-0.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.7	-1.1	1.6	0.4	0.5	-0.3	-0.3	0.3
Supplements: Calcium	0.5	0.6	1.5	-0.1	-0.6	-1.1	-0.8	1.2	-0.3	-0.6
Basal cell carcinoma (self-reported)	0.5	0.5	3.2	0.3	-0.0	-0.1	0.6	-0.2	-0.4	-1.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	-1.2	1.2	0.3	0.1	-0.5	0.3	1.2
Impedance of whole body	0.5	2.7	18.3	-0.2	0.0	-0.2	-0.3	0.3	4.3	-0.6
Leg fat mass (left)	0.5	2.1	7.6	0.7	-0.8	-1.6	-0.8	-0.4	-2.8	1.7
Schizophrenia (2018)	0.4	0.8	2.6	0.2	0.9	0.9	0.4	-1.6	0.1	-1.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.1	0.5	-1.0	-0.3	-0.9	1.8	-0.8	-0.1
Trunk fat mass	0.4	1.8	7.2	1.2	-0.1	-1.2	-0.3	-0.1	-2.7	1.5
Number of incorrect matches in round	0.4	0.7	1.6	0.8	-1.0	-0.2	0.4	-1.1	1.3	-0.6
Nervous feelings	0.4	0.8	1.8	1.3	0.6	1.4	0.7	-0.5	1.1	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.5	-1.0	-0.2	0.1	0.1	1.6	0.8	0.8
Impedance of arm (right)	0.4	2.1	8.1	0.6	1.5	1.3	1.1	0.2	2.8	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	2.4	0.4	0.7	0.4	0.8	-0.0	-1.6	0.3
Happiness	0.4	0.5	1.2	-0.9	1.1	0.8	0.2	-0.7	0.1	0.6
Noisy workplace	0.4	0.5	1.4	-0.2	-0.7	0.3	0.3	0.8	-0.8	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	0.5	-0.6	-0.5	-0.3	0.9	-1.2	0.1
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-0.6	0.6	0.2	0.2	-0.8	1.2	0.8
Impedance of arm (left)	0.4	1.7	6.9	0.5	1.1	0.8	0.7	0.5	2.6	-1.4
Headache pain in last month	0.4	0.6	1.7	-1.0	0.4	1.1	1.3	-0.2	0.1	-0.6
Medication: Amlodipine	0.4	0.5	1.5	0.0	1.1	-0.0	-0.4	-1.2	0.0	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	-0.4	0.1	-0.2	-0.0	-1.0	-0.9	1.0
High blood pressure (siblings)	0.4	0.5	1.4	-0.5	0.0	-0.0	-0.4	-1.1	1.2	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.6	0.5	-0.4	-0.6	-0.4	1.3	-0.9	0.2
Mean time to correctly identify matches	0.4	0.8	2.7	0.3	1.3	0.4	0.2	0.4	-0.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	3.1	0.3	0.7	0.6	0.7	1.8	0.1	0.1
Medication for cholesterol	0.4	0.6	2.6	-0.4	0.2	0.9	0.6	-0.2	-1.6	-0.7
Smoking status: Current	0.4	0.6	1.1	0.6	-0.1	0.9	0.9	0.8	-1.0	0.8
Guilty feelings	0.4	0.6	1.3	1.1	0.2	-0.0	0.6	1.1	0.8	0.9
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	1.1	-0.3	-0.0	0.3	-0.1	1.1	1.0
Medication: Bendroflumethiazide	0.4	0.7	3.0	0.3	0.8	-0.3	-0.3	-1.7	-0.9	-0.3
Number of operations (self-reported)	0.4	0.6	3.1	0.8	-0.3	-0.2	-0.3	1.8	-0.4	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.3	0.9	-1.2	-0.0	0.1	0.7	-1.6	-1.8
Worry (Nagel 2018)	0.3	0.7	1.7	0.6	0.3	1.2	1.3	-0.6	0.9	-0.1
Chronotype (morning person)	0.3	0.6	1.3	-0.7	-0.7	1.1	0.9	-0.3	1.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.6	-0.2	-0.1	-0.2	-0.2	-1.3	0.4	0.5
Stomach or abdominal pain in last month	0.3	0.4	1.0	-0.6	0.7	1.0	0.3	-0.3	-0.2	-0.9
Had menopause	0.3	0.4	1.6	0.1	0.1	0.0	-0.5	-0.2	-1.0	1.3
Illnesses of siblings	0.3	0.4	0.8	-0.1	-0.1	0.7	0.9	-0.4	-0.8	-0.9
Weight	0.3	1.6	5.1	0.9	-0.5	-1.2	-0.5	0.4	-2.3	1.9
Worrier / anxious feelings	0.3	0.5	1.7	1.3	0.0	1.1	0.8	0.1	0.4	-0.1
Length of working week for main job	0.3	0.3	0.9	0.4	-0.4	-0.4	-0.7	0.4	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.0	-0.4	0.3	0.6	0.6	0.4	1.4	0.6
Pulse wave peak to peak time	0.3	0.4	0.8	0.7	-0.7	-0.1	-0.0	0.9	-0.8	-0.6
Had major operations	0.3	0.4	1.1	-0.0	-0.6	0.1	0.2	1.0	0.6	1.0
Age at last live birth	0.3	0.5	0.9	0.9	0.8	1.0	0.6	-0.7	0.3	0.3
Medication: Aspirin	0.3	0.4	1.6	-0.7	-0.0	-0.2	-0.1	-0.7	0.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.8	-1.3	0.1	0.7	0.1	0.8	0.4	1.3
Lung FVC	0.2	1.1	2.0	1.1	1.3	0.9	0.3	1.3	-1.4	-0.6
Leg fat-free mass (left)	0.2	0.8	2.3	1.3	0.2	-0.0	0.3	0.8	-0.9	1.5
Age when periods started (menarche)	0.2	0.4	1.2	0.0	-1.1	-0.1	0.1	-0.7	0.9	-0.3
Leg predicted mass (left)	0.2	0.8	2.2	1.3	0.2	-0.0	0.3	0.8	-1.0	1.5
Trunk fat-free mass	0.2	1.0	4.0	0.7	-0.1	0.0	0.3	1.4	0.5	2.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	-0.1	0.2	-0.7	-0.8	0.2	0.4	1.1
Trunk predicted mass	0.2	0.9	3.8	0.6	-0.1	0.1	0.4	1.3	0.6	1.9
Arm fat-free mass (right)	0.2	1.0	5.0	-0.1	-0.6	-0.7	-0.5	1.0	0.2	2.2
Arm predicted mass (right)	0.2	1.2	5.6	0.3	-0.8	-0.8	-0.6	1.1	0.0	2.4
Leg pain on walking	0.2	0.3	0.8	-0.6	0.8	0.1	0.3	-0.1	-0.1	-0.9
Medication: Aspirin	0.2	0.3	1.0	-0.5	-0.2	-0.1	-0.1	-0.9	0.1	1.0
Leg fat-free mass (right)	0.2	0.9	2.3	1.5	0.3	-0.0	0.2	0.9	-0.9	1.5
Loneliness, isolation	0.2	0.3	1.4	-1.2	-0.5	-0.5	-0.2	-0.3	-0.1	0.4
Leg predicted mass (right)	0.2	0.9	2.4	1.5	0.3	-0.1	0.2	0.9	-0.8	1.5
Ever taken oral contraceptive pill	0.2	0.3	0.5	0.4	-0.4	-0.5	-0.7	-0.7	-0.1	0.6
Basal metabolic rate	0.2	0.9	3.7	0.9	-0.3	-0.5	-0.1	1.0	-0.6	1.9
Arm fat-free mass (left)	0.2	0.8	2.8	0.9	-0.6	-0.8	-0.5	0.8	-0.4	1.7
Arm predicted mass (left)	0.2	0.9	3.4	0.8	-0.7	-0.6	-0.4	1.1	-0.5	1.9
Schizophrenia (2014)	0.1	0.3	0.8	-0.6	0.9	0.8	0.2	-0.2	-0.1	0.1
Tanning	0.1	1.6	4.9	1.4	1.0	2.2	1.6	0.4	-0.7	-0.1
Average weekly fortified wine intake	0.1	0.1	0.4	-0.1	0.2	-0.6	-0.7	0.3	0.2	0.0
Lung cancer (father)	0.1	0.2	0.7	-0.1	0.2	0.4	0.6	0.1	0.0	-0.8
Whole body fat-free mass	0.1	0.8	4.0	0.9	0.1	-0.0	0.3	1.0	-0.0	2.0
Whole body water mass	0.1	0.8	3.7	0.9	0.0	-0.1	0.2	1.1	-0.2	1.9
Hair Pigment	0.0	1.0	5.0	0.1	0.3	-0.4	-0.3	-0.9	2.2	0.8
Medication: Blood pressure	0.0	0.1	0.2	0.4	0.4	-0.3	-0.1	-0.4	0.0	0.4

Hub : Genes

USP3

Models

Trait associations