Best TWAS P=3.63e-63 · Best GWAS P=3.5e-60 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TNFAIP8L3 | 0.12 | 0.07 | blup | 462 | 0.09 | 1.2e-10 | -3.20 | -5.5 | 4.9e-08 | -0.39 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Tibial | GLDN | 0.10 | 0.02 | lasso | 6 | 0.05 | 1.2e-04 | 9.14 | -8.4 | 5.4e-17 | 0.15 | 0.42 | 0.20 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | USP8 | 0.05 | -0.01 | enet | 9 | -0.01 | 5.6e-01 | 4.46 | -5.5 | 3.5e-08 | -0.01 | 0.04 | 0.24 | TRUE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | RP11-707P17.2 | 0.11 | 0.00 | lasso | 2 | 0.02 | 7.5e-02 | 1.19 | -6.3 | 3.0e-10 | -0.48 | 0.26 | 0.09 | FALSE |
| 5 | GTEx | Esophagus Mucosa | RP11-707P17.2 | 0.14 | 0.03 | enet | 33 | 0.03 | 2.7e-03 | 7.00 | -6.7 | 2.6e-11 | -0.21 | 0.10 | 0.05 | FALSE |
| 6 | GTEx | Esophagus Muscularis | SPPL2A | 0.19 | 0.13 | lasso | 5 | 0.11 | 2.8e-07 | -5.39 | -5.4 | 7.1e-08 | 0.14 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Heart Left Ventricle | TNFAIP8L3 | 0.11 | 0.02 | enet | 12 | 0.01 | 1.4e-01 | 2.65 | 10.9 | 1.1e-27 | 0.58 | 0.02 | 0.81 | FALSE |
| 8 | GTEx | Testis | AP4E1 | 0.22 | 0.05 | lasso | 3 | 0.08 | 2.4e-04 | 2.62 | 6.5 | 1.1e-10 | 0.12 | 0.46 | 0.04 | TRUE |
| 9 | GTEx | Testis | USP8 | 0.16 | 0.12 | lasso | 2 | 0.10 | 3.4e-05 | 4.20 | 5.2 | 2.5e-07 | -0.03 | 0.44 | 0.19 | TRUE |
| 10 | METSIM | Adipose | GLDN | 0.21 | 0.10 | enet | 28 | 0.16 | 9.4e-23 | -0.19 | 5.6 | 1.7e-08 | 0.22 | 1.00 | 0.00 | TRUE |
| 11 | NTR | Blood | AP4E1 | 0.02 | 0.00 | blup | 499 | 0.01 | 7.7e-05 | 0.53 | -6.7 | 2.1e-11 | -0.51 | 0.24 | 0.25 | TRUE |
| 12 | YFS | Blood | AP4E1 | 0.08 | 0.05 | lasso | 7 | 0.07 | 1.1e-22 | -1.11 | -5.4 | 7.7e-08 | -0.27 | 1.00 | 0.00 | TRUE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CYP19A1 | 0.04 | 0.00 | blup | 209 | 0.01 | 2.3e-02 | 11.20 | 16.8 | 3.6e-63 | 0.73 | 0.02 | 0.78 | TRUE |
| 14 | The Cancer Genome Atlas | Glioblastoma Multiforme | SPPL2A | 0.22 | 0.13 | lasso | 1 | 0.09 | 9.4e-04 | -5.32 | -5.3 | 1.0e-07 | 0.13 | 0.00 | 0.87 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | SPPL2A | 0.07 | 0.06 | lasso | 2 | 0.05 | 9.3e-07 | -5.39 | -5.4 | 7.8e-08 | 0.12 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SPPL2A | 0.43 | 0.35 | enet | 9 | 0.34 | 2.1e-14 | -5.26 | -5.1 | 3.1e-07 | 0.14 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | GLDN | 0.24 | 0.00 | blup | 110 | 0.06 | 1.0e-02 | 8.90 | -10.3 | 8.0e-25 | -0.09 | 0.03 | 0.16 | TRUE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | USP8 | 0.10 | 0.07 | blup | 59 | 0.07 | 1.2e-07 | 4.23 | -5.8 | 6.4e-09 | 0.01 | 0.03 | 0.96 | TRUE |