Best TWAS P=2.46e-09 · Best GWAS P=6.46e-11 conditioned to 0.0074
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SPECC1 | 0.24 | 0.21 | lasso | 3 | 0.26 | 4.2e-31 | -6.5 | 6.0 | 2.5e-09 | -0.92 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | SPECC1 | 0.12 | 0.13 | lasso | 2 | 0.11 | 1.6e-04 | -5.8 | 5.8 | 4.8e-09 | -1.00 | 0.03 | 0.91 | FALSE |
| 3 | GTEx | Pancreas | RP11-78O7.2 | 0.10 | 0.00 | enet | 28 | 0.00 | 4.2e-01 | -5.9 | -5.5 | 2.8e-08 | 0.64 | 0.04 | 0.72 | FALSE |
| 4 | GTEx | Testis | USP32P3 | 0.11 | 0.19 | lasso | 3 | 0.16 | 8.6e-08 | -5.4 | -5.6 | 1.7e-08 | 0.97 | 0.03 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CYTSB | 0.03 | 0.03 | lasso | 4 | 0.02 | 2.8e-05 | -5.8 | 5.8 | 7.9e-09 | -0.99 | 0.04 | 0.96 | FALSE |