[Hub]/) : Traits : Heel T-Score : ← →

chr17:25,950,220-30,556,282

Best TWAS P=3.08e-42 · Best GWAS P=1.17e-38 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABHD15	0.07	0.03	bslmm	319	0.04	3.4e-05	-0.15	6.3	2.8e-10	0.14	0.46	0.02	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EFCAB5	0.11	0.18	blup	392	0.17	1.7e-20	10.94	11.6	5.7e-31	-0.75	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLDIP2	0.07	0.07	lasso	2	0.07	1.2e-08	8.15	-8.2	3.1e-16	0.07	0.58	0.41	FALSE
4	CommonMind	Brain Pre-frontal Cortex	SLC46A1	0.09	0.13	lasso	3	0.13	2.0e-15	8.03	8.0	1.0e-15	-0.07	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	SSH2	0.05	0.00	enet	37	0.02	3.7e-03	10.92	9.6	6.6e-22	-0.43	0.14	0.42	FALSE
6	CommonMind	Brain Pre-frontal Cortex	TMEM199	0.05	0.03	enet	19	0.02	5.6e-04	-9.49	-7.7	1.6e-14	0.13	0.00	1.00	FALSE
7	GTEx	Adipose Subcutaneous	POLDIP2	0.07	0.04	lasso	4	0.03	2.9e-03	7.80	-7.7	9.9e-15	0.06	0.18	0.22	FALSE
8	GTEx	Adipose Subcutaneous	TMEM199	0.07	0.05	lasso	2	0.02	5.5e-03	8.15	-8.4	2.9e-17	0.10	0.03	0.94	FALSE
9	GTEx	Artery Tibial	SARM1	0.09	0.05	enet	17	0.02	4.8e-03	8.67	8.4	5.1e-17	-0.11	0.05	0.87	FALSE
10	GTEx	Artery Tibial	BLMH	0.12	0.04	enet	16	0.08	6.7e-07	-5.21	8.1	5.1e-16	-0.69	0.10	0.90	FALSE
11	GTEx	Brain Cortex	POLDIP2	0.22	0.11	lasso	4	0.14	1.2e-04	8.24	-7.9	2.9e-15	0.05	0.04	0.87	FALSE
12	GTEx	Brain Cortex	GOSR1	0.20	0.20	enet	7	0.18	1.4e-05	-4.64	-6.0	2.7e-09	0.35	0.81	0.05	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	CORO6	0.11	0.10	lasso	2	0.05	2.2e-02	11.53	-12.6	3.1e-36	0.95	0.03	0.89	FALSE
14	GTEx	Breast Mammary Tissue	TMEM199	0.13	0.07	lasso	3	0.05	1.0e-03	8.65	-8.4	3.4e-17	0.09	0.01	0.91	FALSE
15	GTEx	Cells Transformed fibroblasts	BLMH	0.07	0.04	lasso	2	0.04	2.8e-04	-5.20	5.1	2.9e-07	-0.42	0.72	0.03	FALSE
16	GTEx	Cells Transformed fibroblasts	CPD	0.04	0.00	lasso	3	0.03	4.4e-03	4.71	6.3	2.3e-10	-0.45	0.07	0.62	FALSE
17	GTEx	Cells Transformed fibroblasts	TMEM97	0.09	0.05	lasso	11	0.04	6.3e-04	8.15	-8.1	5.5e-16	0.08	0.21	0.08	FALSE
18	GTEx	Cells Transformed fibroblasts	TMEM199	0.08	0.02	lasso	3	0.00	2.1e-01	8.03	-8.2	3.1e-16	0.07	0.02	0.88	FALSE
19	GTEx	Cells Transformed fibroblasts	CTB-96E2.7	0.09	0.02	lasso	5	0.00	2.3e-01	8.15	-8.0	1.9e-15	0.06	0.04	0.46	FALSE
20	GTEx	Esophagus Mucosa	FAM222B	0.10	0.00	enet	33	0.02	2.7e-02	-5.65	-6.6	4.9e-11	-0.06	0.08	0.16	TRUE
21	GTEx	Esophagus Mucosa	CTB-96E2.3	0.05	0.01	enet	7	0.01	8.1e-02	8.63	-7.0	1.9e-12	0.11	0.07	0.45	TRUE
22	GTEx	Esophagus Muscularis	SSH2	0.04	0.01	enet	10	0.00	3.3e-01	9.11	7.2	8.0e-13	-0.70	0.41	0.28	FALSE
23	GTEx	Esophagus Muscularis	TMEM199	0.12	0.01	enet	10	0.05	6.8e-04	-8.75	-7.9	3.0e-15	0.13	0.02	0.94	FALSE
24	GTEx	Heart Atrial Appendage	MYO18A	0.13	0.06	enet	14	0.02	5.7e-02	3.86	5.8	7.5e-09	-0.05	0.31	0.03	TRUE
25	GTEx	Lung	SSH2	0.08	0.05	lasso	6	0.06	2.7e-05	9.40	12.0	3.6e-33	-0.89	0.39	0.61	FALSE
26	GTEx	Lung	ANKRD13B	0.13	0.09	lasso	6	0.08	6.8e-07	-4.10	-6.0	1.6e-09	0.65	0.26	0.73	FALSE
27	GTEx	Lung	TMEM199	0.12	0.04	lasso	7	0.03	3.2e-03	8.15	-8.1	8.0e-16	0.09	0.04	0.91	FALSE
28	GTEx	Lung	CTB-96E2.3	0.10	0.03	enet	14	0.06	4.6e-05	-8.61	-7.1	1.4e-12	0.12	0.02	0.94	FALSE
29	GTEx	Muscle Skeletal	BLMH	0.11	0.00	enet	31	0.03	7.7e-04	-0.90	5.3	1.0e-07	-0.34	0.05	0.46	FALSE
30	GTEx	Nerve Tibial	POLDIP2	0.13	0.07	lasso	1	0.04	5.7e-04	8.22	-8.2	2.0e-16	0.07	0.58	0.29	FALSE
31	GTEx	Nerve Tibial	SSH2	0.05	0.06	lasso	10	0.06	7.8e-05	9.20	9.5	1.9e-21	-0.78	0.67	0.31	FALSE
32	GTEx	Nerve Tibial	TMEM199	0.19	0.15	lasso	5	0.14	8.9e-10	-8.61	-8.6	6.4e-18	0.10	0.58	0.42	FALSE
33	GTEx	Nerve Tibial	CTD-2350C19.1	0.10	0.08	lasso	1	0.06	5.2e-05	6.35	-6.3	2.1e-10	0.05	0.52	0.17	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	TMEM199	0.10	0.00	enet	7	0.01	7.6e-02	-8.75	-6.8	1.0e-11	0.14	0.01	0.93	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	CTB-96E2.3	0.11	0.04	enet	7	0.08	3.3e-05	-8.75	-6.7	1.7e-11	0.13	0.00	0.97	TRUE
36	GTEx	Skin Sun Exposed Lower leg	ANKRD13B	0.08	0.04	lasso	5	0.06	1.4e-05	-9.23	-5.9	3.9e-09	0.66	0.13	0.83	FALSE
37	GTEx	Skin Sun Exposed Lower leg	TMEM199	0.06	0.05	lasso	1	0.02	6.2e-03	-8.75	-8.8	2.2e-18	0.10	0.03	0.90	TRUE
38	GTEx	Skin Sun Exposed Lower leg	CTB-96E2.3	0.07	0.05	lasso	4	0.03	1.8e-03	-8.75	-8.6	9.0e-18	0.10	0.13	0.78	FALSE
39	GTEx	Skin Sun Exposed Lower leg	RP11-68I3.4	0.03	0.00	lasso	3	0.00	4.5e-01	-11.15	7.5	8.2e-14	-0.79	0.05	0.50	TRUE
40	GTEx	Spleen	GIT1	0.15	0.06	lasso	5	0.06	1.4e-02	-11.15	-6.6	5.0e-11	0.80	0.08	0.64	FALSE
41	GTEx	Testis	POLDIP2	0.12	0.07	enet	14	0.07	7.2e-04	8.24	-8.1	5.4e-16	0.05	0.04	0.86	FALSE
42	GTEx	Testis	SSH2	0.06	-0.01	enet	12	-0.01	8.6e-01	10.94	5.9	2.8e-09	-0.61	0.16	0.09	FALSE
43	GTEx	Thyroid	GIT1	0.06	0.08	lasso	5	0.09	3.7e-07	-11.01	11.0	2.9e-28	-0.93	0.49	0.51	FALSE
44	GTEx	Thyroid	SSH2	0.12	0.17	enet	10	0.18	2.0e-13	-11.30	11.4	2.8e-30	-0.95	0.11	0.89	FALSE
45	GTEx	Thyroid	CORO6	0.23	0.36	lasso	5	0.37	1.2e-29	-11.30	11.6	3.9e-31	-0.95	0.70	0.30	FALSE
46	GTEx	Thyroid	ANKRD13B	0.23	0.12	lasso	6	0.18	2.3e-13	10.35	11.4	4.2e-30	-0.83	0.32	0.68	FALSE
47	METSIM	Adipose	ANKRD13B	0.04	0.03	lasso	3	0.05	1.4e-07	9.15	-7.7	1.3e-14	0.72	0.95	0.05	FALSE
48	METSIM	Adipose	BLMH	0.03	0.03	blup	304	0.03	6.0e-05	-3.95	7.4	1.3e-13	-0.64	0.63	0.29	FALSE
49	METSIM	Adipose	CORO6	0.02	0.02	bslmm	314	0.01	1.7e-02	10.35	-13.6	3.1e-42	0.85	0.02	0.95	TRUE
50	METSIM	Adipose	SSH2	0.03	0.03	blup	422	0.02	1.5e-04	-10.51	10.6	1.9e-26	-0.80	0.19	0.81	FALSE
51	METSIM	Adipose	TMEM199	0.06	0.06	lasso	3	0.06	2.7e-09	8.63	-8.6	5.7e-18	0.10	0.03	0.97	FALSE
52	NTR	Blood	CPD	0.04	0.02	enet	23	0.02	4.4e-07	-4.76	5.2	1.9e-07	-0.19	0.94	0.01	FALSE
53	NTR	Blood	SDF2	0.01	0.00	blup	305	0.00	2.0e-02	2.69	5.3	9.1e-08	0.00	0.04	0.18	FALSE
54	NTR	Blood	SSH2	0.04	0.04	enet	22	0.05	1.7e-14	-10.51	7.8	5.0e-15	-0.65	1.00	0.00	FALSE
55	YFS	Blood	ALDOC	0.05	0.05	blup	275	0.05	1.0e-15	-5.47	6.0	2.5e-09	0.07	1.00	0.00	FALSE
56	YFS	Blood	CPD	0.18	0.13	enet	38	0.14	8.5e-42	-4.76	5.4	7.1e-08	-0.32	1.00	0.00	FALSE
57	YFS	Blood	RAB11FIP4	0.16	0.06	enet	18	0.09	5.9e-27	5.09	-5.7	9.4e-09	0.13	1.00	0.00	TRUE
58	YFS	Blood	SARM1	0.11	0.09	lasso	2	0.14	2.8e-43	0.64	-5.4	5.7e-08	0.09	1.00	0.00	FALSE
59	YFS	Blood	SSH2	0.09	0.07	lasso	7	0.10	1.6e-30	-2.48	6.0	2.0e-09	-0.50	1.00	0.00	FALSE
60	YFS	Blood	TMEM199	0.04	0.04	bslmm	268	0.04	2.4e-14	8.02	7.5	8.4e-14	-0.09	0.74	0.26	FALSE
61	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EFCAB5	0.06	0.08	lasso	2	0.07	1.4e-06	8.71	9.4	6.6e-21	-0.79	0.05	0.95	TRUE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	CORO6	0.03	0.01	enet	10	0.01	1.7e-03	3.67	-6.9	5.3e-12	0.71	0.01	0.95	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFCAB5	0.02	0.04	lasso	4	0.04	1.9e-08	10.94	10.6	2.2e-26	-0.83	0.02	0.98	TRUE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	SSH2	0.01	0.01	blup	111	0.01	1.0e-03	-10.61	10.1	5.3e-24	-0.81	0.47	0.39	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC55	0.15	0.01	blup	64	0.04	1.9e-03	10.35	-10.8	4.8e-27	0.82	0.02	0.60	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	EFCAB5	0.06	0.05	blup	79	0.03	5.7e-03	10.94	10.6	2.9e-26	-0.80	0.04	0.93	FALSE
67	The Cancer Genome Atlas	Esophageal Carcinoma	CCDC55	0.27	0.00	blup	64	0.00	3.5e-01	1.61	-9.0	3.3e-19	0.69	0.01	0.26	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFCAB5	0.09	0.12	lasso	5	0.12	3.1e-13	9.38	9.6	9.7e-22	-0.76	0.19	0.81	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SSH2	0.03	0.02	blup	112	0.03	2.4e-04	9.83	9.7	2.3e-22	-0.82	0.38	0.57	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM97	0.12	0.01	enet	12	0.06	2.6e-07	8.15	-5.8	7.4e-09	0.08	0.00	0.99	TRUE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EFCAB5	0.05	0.02	enet	22	0.02	1.7e-02	10.82	8.5	1.8e-17	-0.60	0.03	0.80	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM97	0.13	0.08	lasso	2	0.06	1.8e-04	7.92	-7.5	7.7e-14	0.10	0.00	0.99	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFCAB5	0.07	0.09	enet	16	0.08	4.0e-09	10.74	10.1	5.8e-24	-0.77	0.02	0.98	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM97	0.05	0.01	enet	11	0.03	4.5e-04	1.31	6.2	5.7e-10	-0.09	0.00	0.48	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	EFCAB5	0.06	0.09	lasso	1	0.09	2.9e-10	9.07	9.1	1.2e-19	-0.77	0.71	0.29	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	SSH2	0.06	0.03	blup	112	0.05	2.5e-06	-11.30	8.1	5.5e-16	-0.80	0.13	0.86	TRUE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFCAB5	0.04	0.04	lasso	4	0.05	5.9e-06	9.11	9.8	9.3e-23	-0.76	0.07	0.92	TRUE
78	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFCAB5	0.08	0.01	blup	79	0.03	1.7e-02	9.27	9.4	7.1e-21	-0.76	0.04	0.63	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	BLMH	0.05	0.03	blup	55	0.05	1.1e-05	-3.73	6.6	3.0e-11	-0.57	0.94	0.04	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFCAB5	0.04	0.03	enet	10	0.02	6.0e-03	10.79	10.9	1.2e-27	-0.77	0.03	0.94	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM97	0.10	0.03	enet	7	0.03	1.4e-04	8.15	-6.3	2.9e-10	0.06	0.00	0.97	FALSE
82	The Cancer Genome Atlas	Soft Tissue Sarcoma	EFCAB5	0.06	0.07	lasso	2	0.05	8.2e-04	10.94	10.4	2.2e-25	-0.83	0.03	0.96	FALSE
83	The Cancer Genome Atlas	Stomach Adenocarcinoma	EFCAB5	0.06	0.02	blup	80	0.02	1.1e-02	9.48	7.1	1.2e-12	-0.60	0.04	0.25	FALSE
84	The Cancer Genome Atlas	Thyroid Carcinoma	ABHD15	0.06	0.03	blup	44	0.03	1.1e-03	-6.13	9.2	5.5e-20	-0.45	0.02	0.26	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	ANKRD13B	0.14	0.20	lasso	4	0.19	2.2e-18	-11.30	11.3	1.0e-29	-0.94	0.10	0.90	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	CORO6	0.28	0.40	lasso	3	0.39	6.2e-40	-11.30	11.5	2.1e-30	-0.95	0.44	0.56	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	EFCAB5	0.11	0.18	enet	13	0.20	5.8e-19	10.94	10.7	8.5e-27	-0.81	0.04	0.96	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	GIT1	0.06	0.05	blup	47	0.05	5.2e-06	-11.01	13.2	4.6e-40	-0.90	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	SLC46A1	0.05	0.01	blup	6	0.02	5.0e-03	5.42	5.8	5.8e-09	-0.01	0.00	0.48	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	SLC6A4	0.02	0.03	lasso	3	0.03	2.8e-04	7.86	-6.9	5.7e-12	0.60	0.04	0.54	FALSE
91	The Cancer Genome Atlas	Thyroid Carcinoma	SSH2	0.25	0.18	lasso	5	0.17	4.8e-16	-11.30	11.5	2.1e-30	-0.95	0.08	0.92	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM97	0.17	0.11	lasso	3	0.11	1.8e-10	7.92	-8.1	6.3e-16	0.08	0.00	1.00	FALSE