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chr17:16,419,425-17,948,475

Best TWAS P=2.11e-15 · Best GWAS P=7.86e-15 conditioned to 0.105

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	COPS3	0.06	0.04	lasso	2	0.03	2.4e-04	7.5	7.5	6.9e-14	0.98	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NT5M	0.13	0.10	enet	14	0.10	1.4e-12	4.5	5.3	8.6e-08	0.61	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	FLCN	0.33	0.31	lasso	5	0.31	7.7e-26	7.4	-7.3	2.0e-13	-0.85	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	FLCN	0.26	0.30	enet	28	0.24	6.6e-13	7.1	-7.9	2.1e-15	-0.88	0.04	0.96	TRUE
5	GTEx	Adrenal Gland	FLCN	0.22	0.13	lasso	2	0.07	2.0e-03	7.1	-7.3	3.8e-13	-0.85	0.03	0.94	FALSE
6	GTEx	Artery Aorta	FLCN	0.53	0.50	enet	53	0.54	8.8e-35	7.1	-6.6	3.7e-11	-0.77	0.17	0.83	FALSE
7	GTEx	Artery Coronary	FLCN	0.39	0.46	enet	8	0.42	2.7e-15	7.1	-7.3	3.1e-13	-0.86	0.09	0.91	FALSE
8	GTEx	Artery Tibial	FLCN	0.51	0.57	enet	14	0.53	2.1e-48	7.1	-7.3	3.0e-13	-0.85	0.26	0.74	FALSE
9	GTEx	Brain Caudate basal ganglia	FLCN	0.20	0.27	lasso	4	0.19	3.9e-06	7.1	-7.2	5.1e-13	-0.83	0.04	0.93	FALSE
10	GTEx	Brain Cerebellar Hemisphere	FLCN	0.32	0.26	enet	8	0.25	4.1e-07	6.6	-7.1	1.3e-12	-0.84	0.08	0.89	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	FLCN	0.18	0.19	lasso	2	0.02	8.3e-02	7.4	-7.2	7.2e-13	-0.85	0.05	0.92	FALSE
12	GTEx	Breast Mammary Tissue	FLCN	0.38	0.46	enet	18	0.43	5.8e-24	7.1	-7.3	3.3e-13	-0.83	0.19	0.81	FALSE
13	GTEx	Breast Mammary Tissue (Female)	FLCN	0.34	0.36	lasso	5	0.34	8.0e-11	7.1	-7.4	1.1e-13	-0.88	0.03	0.97	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	FLCN	0.33	0.17	enet	35	0.16	5.8e-06	7.7	-7.2	4.3e-13	-0.77	0.01	0.99	FALSE
15	GTEx	Cells Transformed fibroblasts	FLCN	0.35	0.28	enet	11	0.29	6.4e-22	7.4	-7.3	3.8e-13	-0.84	0.08	0.92	FALSE
16	GTEx	Colon Sigmoid	FLCN	0.45	0.47	enet	17	0.47	1.3e-18	7.1	-7.6	3.2e-14	-0.87	0.10	0.90	FALSE
17	GTEx	Colon Transverse	FLCN	0.29	0.35	lasso	3	0.34	4.1e-17	7.1	-7.1	1.1e-12	-0.83	0.16	0.84	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	FLCN	0.43	0.45	enet	11	0.44	1.1e-17	7.1	-7.0	2.0e-12	-0.84	0.13	0.87	FALSE
19	GTEx	Esophagus Mucosa	FLCN	0.39	0.42	enet	14	0.41	1.3e-29	7.1	-7.1	1.1e-12	-0.83	0.12	0.88	FALSE
20	GTEx	Esophagus Muscularis	FLCN	0.50	0.58	enet	10	0.57	4.6e-42	7.1	-7.5	4.4e-14	-0.87	0.21	0.79	FALSE
21	GTEx	Heart Atrial Appendage	FLCN	0.39	0.47	enet	11	0.48	2.4e-24	6.6	-7.2	4.1e-13	-0.86	0.12	0.88	FALSE
22	GTEx	Heart Left Ventricle	FLCN	0.46	0.48	lasso	7	0.48	1.6e-28	7.1	-7.2	6.1e-13	-0.83	0.12	0.88	FALSE
23	GTEx	Liver	FLCN	0.20	0.01	enet	14	0.00	3.1e-01	7.4	-6.2	6.5e-10	-0.81	0.02	0.86	FALSE
24	GTEx	Lung	FLCN	0.39	0.44	enet	6	0.42	1.5e-34	7.1	-7.2	4.6e-13	-0.85	0.18	0.82	FALSE
25	GTEx	Muscle Skeletal	FLCN	0.10	0.08	lasso	3	0.06	7.3e-07	7.1	-7.0	2.1e-12	-0.82	0.13	0.87	FALSE
26	GTEx	Nerve Tibial	FLCN	0.43	0.43	enet	32	0.45	6.7e-35	7.4	-7.6	3.3e-14	-0.85	0.08	0.92	FALSE
27	GTEx	Ovary	FLCN	0.22	0.21	enet	4	0.12	9.3e-04	7.1	-7.2	7.4e-13	-0.84	0.06	0.79	FALSE
28	GTEx	Pancreas	FLCN	0.15	0.15	lasso	2	0.12	8.5e-06	7.4	-7.5	5.2e-14	-0.84	0.06	0.93	FALSE
29	GTEx	Prostate	FLCN	0.32	0.40	enet	6	0.27	2.2e-07	7.4	-7.3	4.0e-13	-0.86	0.05	0.94	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	FLCN	0.17	0.16	lasso	3	0.15	1.2e-08	7.1	-7.4	1.4e-13	-0.92	0.08	0.92	FALSE
31	GTEx	Skin Sun Exposed Lower leg	FLCN	0.23	0.18	lasso	6	0.18	6.0e-15	6.6	-7.0	1.9e-12	-0.83	0.17	0.83	FALSE
32	GTEx	Small Intestine Terminal Ileum	FLCN	0.29	0.20	enet	6	0.11	1.9e-03	-6.8	-7.4	1.8e-13	-0.92	0.02	0.88	FALSE
33	GTEx	Spleen	FLCN	0.57	0.38	lasso	4	0.39	6.0e-11	6.6	-6.8	1.5e-11	-0.82	0.11	0.89	FALSE
34	GTEx	Stomach	FLCN	0.35	0.38	lasso	2	0.38	2.2e-19	7.1	-7.2	5.7e-13	-0.84	0.11	0.89	FALSE
35	GTEx	Testis	FLCN	0.47	0.41	enet	38	0.38	9.8e-18	7.1	-6.1	1.1e-09	-0.75	0.10	0.90	FALSE
36	GTEx	Thyroid	FLCN	0.31	0.34	enet	9	0.30	1.1e-23	7.1	-7.5	9.7e-14	-0.88	0.12	0.88	FALSE
37	GTEx	Uterus	FLCN	0.53	0.37	lasso	4	0.43	6.1e-10	6.6	-6.5	1.0e-10	-0.79	0.10	0.82	FALSE
38	GTEx	Vagina	FLCN	0.21	0.22	enet	9	0.22	9.8e-06	7.1	-7.0	1.8e-12	-0.81	0.06	0.84	FALSE
39	GTEx	Whole Blood	COPS3	0.14	0.17	lasso	6	0.16	1.3e-14	-6.8	-6.9	4.9e-12	-0.96	0.01	0.99	FALSE
40	METSIM	Adipose	FLCN	0.36	0.34	lasso	6	0.33	2.1e-50	7.1	-7.2	5.9e-13	-0.83	0.26	0.74	FALSE
41	NTR	Blood	COPS3	0.03	0.03	lasso	5	0.02	1.4e-08	7.5	-7.6	3.2e-14	-0.99	0.00	1.00	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	FLCN	0.21	0.12	lasso	10	0.16	1.8e-19	5.2	-6.2	4.0e-10	-0.64	1.00	0.00	FALSE
43	YFS	Blood	COPS3	0.17	0.22	lasso	3	0.22	8.3e-69	7.6	-7.6	3.0e-14	-0.99	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLCN	0.04	0.04	lasso	2	0.04	1.9e-04	5.7	-6.0	2.1e-09	-0.75	0.09	0.70	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLCN	0.02	0.02	blup	49	0.02	2.4e-05	5.7	-7.3	2.2e-13	-0.87	0.16	0.82	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	FLCN	0.06	0.07	lasso	3	0.07	8.3e-05	6.6	-7.0	3.7e-12	-0.86	0.04	0.94	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	MPRIP	0.07	0.02	blup	100	0.05	4.3e-04	2.8	-5.4	7.9e-08	-0.43	0.06	0.18	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	FLCN	0.15	0.15	lasso	2	0.13	1.0e-04	7.5	-7.2	8.2e-13	-0.95	0.02	0.88	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLCN	0.03	0.04	enet	8	0.02	3.9e-03	7.5	-7.7	1.7e-14	-0.98	0.00	0.99	FALSE
50	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLCN	0.10	0.04	enet	4	0.06	2.5e-04	4.5	-6.6	3.6e-11	-0.74	0.03	0.30	FALSE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLCN	0.03	0.03	lasso	4	0.02	6.7e-04	7.1	-7.3	2.1e-13	-0.78	0.08	0.78	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	FLCN	0.03	0.02	enet	5	0.02	6.7e-04	6.6	-6.6	4.0e-11	-0.84	0.11	0.80	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLCN	0.04	0.03	blup	49	0.03	4.3e-04	7.1	-7.5	5.3e-14	-0.91	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLCN	0.09	0.10	enet	8	0.08	3.5e-04	7.8	-7.8	4.3e-15	-0.97	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLCN	0.15	0.11	lasso	4	0.16	5.1e-07	7.4	-6.7	2.0e-11	-0.82	0.07	0.92	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLCN	0.05	0.02	enet	6	0.05	9.6e-06	3.8	-6.7	2.2e-11	-0.86	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Soft Tissue Sarcoma	PLD6	0.19	0.01	enet	8	0.04	2.2e-03	6.0	6.6	3.4e-11	0.53	0.02	0.26	FALSE
58	The Cancer Genome Atlas	Skin Cutaneous Melanoma	FLCN	0.21	0.07	lasso	2	0.10	1.5e-03	7.5	-7.6	4.0e-14	-0.85	0.01	0.71	FALSE