TWAS hub - SPECC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2450	0.0560	0.0e+00	0.214	0.243	0.253	0.243	0.257	1.4e-25	3.1e-29	1.4e-30	2.8e-29	4.2e-31
2	GTEx	Adipose Subcutaneous	0.0690	0.0350	1.6e-03	0.001	NA	0.016	NA	0.004	2.5e-01	NA	1.7e-02	NA	1.5e-01
3	GTEx	Adipose Visceral Omentum	0.0840	0.0430	3.5e-03	0.006	NA	0.023	NA	0.011	1.5e-01	NA	2.3e-02	NA	8.2e-02
4	GTEx	Artery Tibial	0.2408	0.0687	5.2e-11	0.213	NA	0.209	NA	0.211	1.4e-16	NA	2.5e-16	NA	2.0e-16
5	GTEx	Cells EBV-transformed lymphocytes	0.1170	0.0650	2.9e-03	0.131	NA	0.009	NA	0.113	4.9e-05	NA	1.5e-01	NA	1.6e-04
6	GTEx	Colon Transverse	0.1000	0.0410	5.7e-05	0.059	NA	0.086	NA	0.102	8.6e-04	NA	6.9e-05	NA	1.5e-05
7	GTEx	Esophagus Muscularis	0.1400	0.0590	3.6e-04	0.040	NA	0.012	NA	0.031	1.8e-03	NA	5.6e-02	NA	5.2e-03
8	GTEx	Nerve Tibial	0.2140	0.0527	7.8e-12	0.149	NA	0.222	NA	0.181	1.0e-10	NA	1.1e-15	NA	7.7e-13
9	GTEx	Skin Not Sun Exposed Suprapubic	0.1600	0.0750	2.3e-03	0.015	NA	0.090	NA	0.048	5.1e-02	NA	1.2e-05	NA	1.2e-03
10	GTEx	Skin Sun Exposed Lower leg	0.0580	0.0260	1.4e-03	0.066	NA	0.038	NA	0.053	3.8e-06	NA	3.7e-04	NA	3.1e-05
11	METSIM	Adipose	0.0706	0.0234	7.4e-09	0.054	0.061	0.048	0.057	0.037	1.5e-08	1.9e-09	8.6e-08	5.2e-09	2.8e-06
12	NTR	Blood	0.0649	0.0207	3.1e-07	0.020	0.019	0.019	0.022	0.022	2.4e-07	5.9e-07	5.6e-07	1.1e-07	1.2e-07
13	ROSMAP	Brain Pre-frontal Cortex	0.1679	0.0369	0.0e+00	0.267	0.257	0.261	0.255	0.262	2.8e-34	8.2e-33	1.8e-33	1.2e-32	1.3e-33

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Worry (Nagel 2018)	6.9	14.6	28.4	5.3	4.7	4.4	1.5	4.3	3.8	-1.6	4.3	4.5	4.5	3.3	3.3	1.2
Commuting to job workplace: Cycle	5.5	6.6	13.0	-3.2	-3.6	-2.6	-2.1	-2.9	-3.3	1.9	-2.4	-3.1	-2.4	-2.4	-0.6	-0.8
Suffer from ‘nerves’	5.1	8.0	13.6	3.6	2.9	3.6	1.4	3.4	3.0	-1.4	2.9	2.8	3.0	2.2	3.7	1.5
Tense / ‘highly strung’	4.2	6.9	16.3	3.0	3.2	2.6	-0.2	1.9	2.1	-1.3	3.6	3.0	4.0	2.0	3.5	-0.2
Migraine (self-reported)	3.9	4.9	11.3	3.1	2.5	2.0	0.8	2.5	1.5	0.1	3.1	1.2	2.7	2.0	3.4	1.0
Qualifications: None of the above	3.6	7.6	20.0	3.8	2.1	2.3	0.8	2.9	2.9	-1.5	3.1	3.0	3.3	1.8	4.5	1.7
Worrier / anxious feelings	3.6	6.9	11.4	3.4	3.4	3.2	1.0	3.0	2.2	-0.8	3.1	3.2	3.0	2.4	2.3	0.9
Guilty feelings	3.6	5.4	16.7	-1.9	-0.0	-0.9	-3.1	-2.6	-4.0	4.1	0.7	1.0	0.6	1.3	-0.1	-3.7
Ovarian Cancer	3.5	4.6	13.0	-2.8	-1.3	-3.6	-0.9	-2.5	-0.7	-1.3	-3.1	-1.3	-2.3	-3.1	-1.2	-0.3
Angina	3.5	4.7	12.0	1.2	2.1	1.6	-2.4	-0.3	-0.9	1.8	3.2	1.7	3.5	2.8	1.4	-2.7
Illnesses of siblings: Diabetes	3.5	4.3	16.8	0.9	3.2	1.0	-1.5	0.3	-0.5	1.5	2.2	4.1	2.7	2.4	0.4	-2.0
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	13.8	-2.7	-1.7	-3.1	0.3	-1.8	-1.2	-0.1	-3.0	-3.7	-3.0	-2.3	-2.9	-0.3
Nervous feelings	3.2	6.1	12.7	2.9	2.6	3.6	1.4	2.7	2.8	-1.7	2.5	3.0	2.3	1.8	2.4	0.9
Diabetes (self-reported)	3.1	4.8	15.3	-2.3	-0.8	-1.7	-3.9	-3.4	-2.5	1.0	-0.7	0.1	0.7	-2.1	-1.7	-3.3
Diabetes diagnosed by doctor	3.0	4.9	14.1	-2.5	-1.2	-1.9	-3.8	-3.4	-2.6	1.1	-0.8	-0.9	0.4	-2.1	-1.7	-3.1
Serious illness, injury or assault to yourself	2.9	3.6	7.6	2.3	1.4	2.0	-0.0	1.6	0.3	1.0	2.6	2.4	2.2	2.4	2.8	0.4
Angina (self-reported)	2.9	3.9	10.2	1.2	1.9	1.6	-2.2	-0.1	-0.8	1.7	2.9	1.5	3.2	2.5	1.1	-2.4
Blood Red Count	2.8	27.3	72.8	-5.9	-2.6	-4.8	-8.5	-7.6	-6.8	3.6	-1.2	0.7	0.5	-2.4	-5.0	-8.2
Illnesses of mother	2.7	3.3	9.6	0.7	1.0	1.1	-1.6	-0.4	-1.5	2.3	2.1	3.1	2.3	1.5	2.3	-1.9
Age at first live birth	2.7	4.7	9.5	-2.7	-1.0	-2.4	-1.9	-2.7	-3.1	2.3	-1.6	-1.7	-1.5	-1.9	-2.3	-2.3
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	10.7	-1.1	0.3	0.1	-3.2	-2.0	-2.2	2.0	1.4	1.0	2.4	0.4	1.1	-3.3
Neuroticism score	2.6	5.4	12.6	2.2	3.5	2.6	-0.1	1.6	0.7	0.4	3.3	3.2	3.3	1.9	2.7	-0.6
Mother’s age at death	2.6	3.2	5.9	-2.3	-1.0	-1.8	-2.1	-2.4	-2.2	1.1	-1.7	-0.2	-1.3	-1.9	-2.3	-1.7
Blood Platelet Count	2.5	28.5	66.9	6.1	4.1	7.6	4.1	6.0	8.2	-7.2	3.1	3.1	3.0	2.2	5.3	5.3
Neuroticism	2.5	6.0	11.9	2.9	3.5	3.4	1.0	2.3	2.1	-0.7	3.0	3.0	2.9	2.2	1.9	0.3
Maternal smoking around birth	2.4	3.5	9.4	1.3	2.1	1.2	-0.3	0.5	-0.8	1.9	3.1	2.9	2.5	2.3	1.8	-1.0
Alcohol usually taken with meals	2.4	4.0	13.0	-0.7	1.1	-1.0	-3.6	-1.8	-2.5	2.6	1.1	0.4	1.9	1.1	-0.8	-3.6
Neuroticism (2016)	2.3	3.3	9.9	2.2	2.6	3.1	0.0	1.7	0.9	0.3	2.2	1.6	1.9	0.9	2.3	0.8
Systolic blood pressure, automated reading	2.3	6.6	14.6	3.1	0.8	3.4	1.6	3.0	3.8	-3.2	1.9	0.3	1.9	1.5	3.3	2.5
Pulse wave reflection index	2.3	2.8	5.2	-2.2	-1.5	-2.1	-1.2	-2.1	-1.8	0.3	-2.3	-0.7	-2.0	-2.1	-1.1	-0.6
Supplements: Vitamin C	2.3	2.7	6.3	-1.0	-2.4	-1.5	-2.5	-1.5	-2.4	2.4	-0.1	-1.3	0.3	0.1	-0.6	-1.8
Age at First Birth	2.2	3.1	7.4	-2.7	-1.3	-1.4	-0.4	-2.4	-2.3	1.4	-1.5	-1.8	-1.9	-1.8	-1.5	-1.5
Schizophrenia (2014)	2.2	4.9	14.2	3.2	0.0	1.8	0.0	2.5	1.4	0.6	3.2	0.0	2.4	3.8	3.1	1.4
Medication: Omeprazole (e.g. Zanprol)	2.2	2.6	10.4	1.2	0.8	1.7	-1.5	0.3	-0.2	0.7	1.6	2.8	2.0	1.1	3.2	-0.3
Neuroticism (Nagel 2018)	2.1	5.0	10.4	3.1	2.3	3.2	1.3	2.5	2.5	-1.5	2.1	2.6	2.2	1.4	2.0	1.1
Sensitivity / hurt feelings	2.1	3.5	8.9	1.5	2.2	2.6	0.4	1.2	0.7	0.1	2.6	3.0	2.2	2.1	2.3	-0.3
Multivitamins +/- minerals	2.1	2.6	8.2	-1.6	-1.3	-1.0	-0.8	-1.5	-2.7	2.9	-0.4	-1.7	-1.0	0.2	-1.9	-1.6
Irritability	2.1	3.6	7.7	1.8	2.5	2.7	1.0	2.0	2.4	-1.9	1.6	2.8	1.6	1.0	1.4	0.7
Heel T-Score	2.0	16.1	35.5	6.0	4.4	5.0	2.1	5.8	3.2	0.8	4.6	3.8	3.1	4.8	2.0	2.8
Vitamin and mineral supplements	2.0	2.7	10.3	1.4	1.3	0.9	2.0	1.4	2.8	-3.2	-0.2	1.2	-0.2	-0.5	0.8	1.8
Taking other prescription medications	1.9	2.9	10.0	1.8	1.4	1.8	-1.3	1.2	0.3	0.5	2.7	1.6	3.2	1.5	1.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.0	11.7	1.9	2.0	1.1	-1.1	0.8	0.8	-0.7	2.4	1.3	3.4	-0.2	3.0	-0.2
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.1	-2.1	-1.6	-1.7	-0.3	-1.7	-0.2	-1.7	-2.5	-0.4	-1.9	-2.4	-0.6	-0.1
Exposure to tobacco smoke outside home	1.9	2.5	8.0	1.2	0.7	1.7	-1.4	0.1	-0.7	1.7	2.2	1.0	2.8	1.6	1.8	-1.6
Qualifications: College or University degree	1.9	6.1	16.5	-2.3	-1.5	-2.0	-1.9	-2.2	-3.8	4.1	-0.6	-2.5	-1.1	-0.4	-3.2	-3.1
Age at last live birth	1.9	2.7	5.3	-2.0	-0.8	-1.3	-1.2	-2.1	-2.3	1.4	-1.2	-1.3	-1.2	-1.6	-2.3	-1.8
Average weekly red wine intake	1.9	2.8	11.2	-1.5	-0.6	-0.9	-1.3	-1.8	-3.3	3.3	-0.5	-0.5	-0.7	-0.5	-1.1	-1.8
Bipolar Disorder (2018)	1.8	2.8	7.6	1.5	0.0	1.5	2.5	2.0	2.8	-2.5	-0.1	0.0	-0.3	0.5	0.7	2.6
HbA1C	1.8	2.0	5.5	-1.7	-1.6	-2.0	-0.6	-1.3	-0.9	0.2	-2.0	-0.4	-1.8	-1.1	-2.4	-0.5
Triglycerides	1.8	2.9	7.1	2.5	2.7	0.6	0.1	2.3	1.3	0.1	2.0	0.9	2.2	1.0	2.4	1.0
Systolic Blood Pressure	1.8	8.9	18.5	4.0	1.5	3.8	2.2	3.7	4.3	-3.2	2.6	0.8	2.3	2.3	3.1	2.8
Type 2 Diabetes (T2D) (2018)	1.8	3.4	9.8	-2.0	-1.4	-1.7	-3.1	-2.8	-2.2	1.2	-0.9	-0.1	0.0	-1.6	-1.2	-2.5
Number of treatments/medications taken	1.8	3.2	9.5	2.2	0.9	1.2	-1.4	1.4	0.5	0.5	2.4	1.3	3.1	1.9	3.0	0.1
Average weekly spirits intake	1.8	2.2	7.6	-0.6	-1.2	0.2	-2.2	-1.3	-2.5	2.8	0.5	0.6	0.9	0.1	1.5	-1.5
Bilateral oophorectomy (both ovaries removed)	1.8	2.0	4.7	1.9	1.1	1.7	0.9	1.9	2.2	-1.5	0.5	1.4	0.8	-0.4	1.4	1.6
Supplements: Glucosamine	1.8	2.3	7.8	-1.7	-1.6	-2.8	-1.0	-1.1	-0.9	-0.0	-2.2	-0.8	-1.7	-2.2	0.3	0.8
Falls in the last year	1.8	2.4	7.3	-1.3	-0.3	-1.0	-2.7	-2.2	-2.5	1.9	0.6	-0.5	0.9	0.5	0.1	-2.2
Overall health rating	1.8	3.9	15.4	1.5	2.1	2.0	-1.9	0.2	0.2	0.0	2.6	2.3	3.9	0.4	2.7	-1.4
Eye problems/disorders: Cataract	1.8	2.1	4.5	1.3	2.1	1.2	2.1	1.6	1.8	-1.4	0.7	1.7	-0.0	1.0	1.0	1.4
Medication: Lansoprazole	1.7	2.0	7.6	1.4	0.8	2.8	0.0	0.9	1.0	-0.3	1.7	1.8	1.8	1.4	1.4	0.0
Glaucoma (self-reported)	1.7	2.0	6.0	1.4	0.6	1.4	-1.2	0.6	-0.5	1.4	1.9	0.2	2.4	1.2	2.5	-0.4
Health satisfaction	1.7	2.2	6.7	1.3	1.5	-0.0	-1.4	0.2	-0.6	1.0	2.0	1.9	2.6	1.6	1.9	-1.0
Mean time to correctly identify matches	1.7	3.3	10.1	0.0	0.9	-0.6	-3.2	-1.5	-1.8	1.8	2.0	0.8	2.6	1.1	1.1	-2.9
Bipolar Disorder or Schizophrenia	1.6	4.0	8.5	2.9	0.0	1.7	0.0	2.8	2.5	-1.3	1.9	0.0	1.2	2.4	2.7	2.6
Hand grip strength (left)	1.6	4.2	11.4	-2.7	-2.3	-1.9	0.7	-1.4	-0.2	-1.2	-3.4	-0.7	-3.3	-2.4	-2.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	7.4	2.7	2.0	2.4	0.8	2.2	1.5	-0.1	2.2	1.0	2.0	2.5	2.2	1.1
Qualifications: CSEs or equivalent	1.6	2.1	4.7	1.4	-0.5	1.8	1.5	1.4	2.1	-1.8	-0.8	2.2	-0.5	-0.8	-0.3	1.9
High blood pressure	1.6	4.5	10.7	3.1	0.6	2.5	1.6	3.3	2.5	-0.8	2.2	0.1	1.7	2.2	2.3	2.3
Hearing difficulty/problems with background noise	1.6	2.5	6.2	0.9	1.6	0.6	-2.0	0.3	-1.3	2.1	2.5	0.9	2.4	0.8	2.0	-0.9
Pain all over the body in last month	1.6	1.7	4.9	-1.3	0.1	-1.4	-2.1	-1.8	-0.8	-0.3	-0.3	2.2	0.7	-1.7	0.8	-1.2
Medication: Simvastatin	1.6	2.3	5.5	2.3	1.4	1.1	0.2	1.5	1.6	-0.9	1.7	1.6	2.1	0.6	2.3	1.0
Impedance of arm (right)	1.6	7.7	15.9	3.6	4.0	2.9	-0.0	2.4	1.6	-0.1	3.7	2.9	3.6	3.3	2.9	0.2
Pulse wave Arterial Stiffness index	1.6	1.8	4.5	-1.4	-0.5	-0.9	0.7	-1.0	0.4	-1.9	-2.1	-1.4	-1.9	-1.5	-1.8	0.1
Impedance of arm (left)	1.6	7.5	16.9	3.1	3.9	2.7	-1.0	1.7	0.9	0.2	4.0	2.9	4.1	3.1	3.0	-0.7
Headache pain in last month	1.6	2.8	8.1	1.8	1.0	1.5	-1.1	1.0	0.1	1.2	2.9	0.9	2.8	1.8	2.4	-0.6
Medication for pain relief, constipation, heartburn	1.6	2.7	9.4	-0.5	0.5	-0.4	3.1	1.1	1.1	-1.1	-1.7	0.1	-2.7	-0.5	-2.9	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.8	-1.9	-1.0	-1.2	-1.0	-1.8	-1.5	0.3	-1.8	-1.3	-1.3	-1.7	-0.5	-1.2
Myopia	1.6	2.3	6.8	-1.1	0.6	-1.5	-1.9	-2.1	-2.3	1.8	0.5	0.4	0.6	0.9	-0.7	-2.6
Vascular/heart problems diagnosed by doctor	1.6	4.3	8.9	-3.0	-1.0	-2.6	-0.8	-3.0	-1.9	0.0	-2.8	-0.5	-2.4	-2.4	-2.2	-1.3
Impedance of whole body	1.6	8.1	15.7	3.7	4.0	3.1	0.0	2.6	1.5	0.1	3.9	3.1	3.7	3.1	3.0	0.4
Schizophrenia (2018)	1.5	3.1	8.8	2.5	0.0	1.1	0.0	1.9	1.0	0.4	2.5	0.0	1.8	2.7	3.0	1.3
Length of working week for main job	1.5	1.6	4.3	1.5	0.9	2.1	1.0	2.1	1.9	-0.5	0.8	0.1	0.8	1.4	-1.1	0.6
Neck or shoulder pain in last month	1.5	2.1	7.6	2.0	0.9	0.6	-0.2	1.1	1.2	-0.7	2.3	-0.8	2.8	0.6	2.2	-0.2
Alcohol intake frequency.	1.5	3.4	8.9	1.3	2.0	3.0	0.9	1.7	2.2	-2.1	1.1	2.5	0.7	0.7	1.9	2.2
Basal cell carcinoma (self-reported)	1.5	1.8	5.4	-1.0	0.2	-0.1	-1.5	-1.5	-2.3	2.3	0.9	0.6	0.7	-0.6	-0.7	-2.1
HDL Cholesterol	1.4	2.3	4.2	-1.9	-1.9	-1.2	0.1	-1.4	-1.4	0.7	-1.9	-1.7	-2.0	-2.0	-1.5	-0.2
Pack years adult smoking proportion	1.4	2.1	9.4	-1.4	-3.1	-1.1	0.8	-0.8	-0.3	-0.6	-1.5	-2.2	-1.3	-1.8	-0.3	0.3
Hand grip strength (right)	1.4	3.8	10.3	-2.0	-1.8	-1.3	1.4	-0.4	0.6	-1.5	-3.2	-1.3	-3.2	-2.1	-2.8	1.0
Stomach or abdominal pain in last month	1.4	1.8	4.7	1.3	1.3	1.7	0.2	1.1	0.5	0.3	1.8	2.2	1.7	1.1	1.9	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	7.6	2.8	1.8	1.9	0.3	1.9	1.1	0.3	2.3	0.6	2.3	2.7	1.9	0.5
Alcohol intake versus 10 years previously	1.4	2.1	5.7	-1.6	-2.4	-1.6	-1.8	-1.8	-1.6	0.4	-0.9	-1.5	-0.5	-2.0	0.7	-0.4
Comparative body size at age 10	1.4	3.9	8.3	-2.0	-2.9	-2.8	-0.4	-1.0	-1.4	0.8	-2.7	-2.5	-2.8	-2.1	-0.7	1.0
Medication: Omeprazole	1.4	1.7	6.5	1.2	0.2	1.9	-0.5	0.8	0.7	-0.3	1.1	2.4	1.2	0.8	2.5	0.4
Medication: Metformin	1.3	1.9	5.8	-1.8	-1.1	-0.7	-1.2	-1.7	-1.1	0.4	-0.8	-1.3	-0.6	-1.6	-2.4	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	5.7	1.6	2.1	1.2	-0.2	0.4	1.5	-1.7	1.3	2.1	2.4	0.3	1.2	-0.5
Medication: Cholesterol lowering	1.3	2.1	4.9	1.9	1.8	1.1	-0.0	1.2	1.3	-0.6	1.9	1.9	2.2	1.2	1.1	-0.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.7	-1.9	-1.9	-0.9	-0.9	-1.8	-1.8	1.0	-1.7	-1.1	-1.8	-1.1	-1.2	-0.9
Pulse wave peak to peak time	1.3	1.5	3.5	1.4	0.5	0.8	-0.4	1.2	-0.2	1.7	1.9	1.2	1.6	1.6	1.5	0.1
Number of full sisters	1.3	1.6	4.2	0.6	0.9	1.0	-0.8	-0.4	-0.7	1.1	1.9	1.4	2.0	1.0	1.9	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	7.7	-2.0	-0.5	-1.1	-1.0	-1.6	-1.5	1.0	-0.9	-0.4	-0.6	-1.2	-2.8	-1.9
Alzheimer’s Disease (in mother)	1.2	1.4	3.5	-0.8	-1.5	-0.1	1.0	-0.1	0.7	-1.5	-1.4	-1.9	-1.7	-0.9	-1.3	0.6
Medication: Atenolol	1.2	1.6	6.5	1.2	0.5	2.5	0.3	1.0	0.5	0.3	1.8	0.3	1.5	2.2	0.0	-0.5
Noisy workplace	1.2	1.4	3.2	1.3	-0.7	1.5	-0.1	1.0	1.3	-0.9	1.2	0.7	1.8	1.8	1.4	0.2
Qualifications: A levels/AS levels or equivalent	1.2	2.6	8.3	-1.8	-0.5	-1.7	-0.4	-1.6	-2.1	1.5	-0.7	-2.9	-1.1	-1.2	-2.0	-1.5
Medication: Ibuprofen	1.2	1.4	5.9	0.5	-0.8	-0.7	-2.1	-0.1	-1.3	2.0	0.5	-0.2	1.0	0.1	2.4	-0.1
Hypertension (Self-reported)	1.2	3.3	8.2	2.7	0.1	1.8	1.6	2.9	2.3	-0.9	1.5	-0.5	1.1	1.6	2.1	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.9	1.2	1.2	2.0	0.1	1.3	0.4	0.9	1.7	1.7	1.3	0.7	0.9	0.0
Long-standing illness, disability or infirmity	1.2	1.8	6.2	0.5	1.2	1.1	-1.8	-0.1	-0.3	0.5	1.9	2.1	2.5	1.0	0.4	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.7	0.8	1.3	1.5	-0.2	0.5	-0.2	1.3	1.6	1.8	1.1	1.9	0.1	-1.1
Intelligence (Savage-Jansen 2018)	1.1	3.3	7.9	-2.6	-0.2	-1.8	-2.0	-2.8	-2.5	1.3	-0.6	-1.6	-0.7	-0.5	-1.9	-2.3
Irritable Bowel Disease (IBD)	1.1	2.7	5.8	2.4	1.8	1.8	0.2	1.9	1.0	0.2	2.4	0.8	2.1	1.9	1.9	1.0
Ulcerative Colitis	1.1	1.6	4.2	2.1	0.0	1.5	0.0	1.9	1.4	-0.5	1.4	0.0	1.0	1.3	1.5	1.5
Allergy or Eczema	1.1	3.0	9.1	1.5	0.6	2.1	2.3	2.0	3.0	-3.0	-0.1	0.1	-0.2	0.7	-0.3	1.9
Average weekly fortified wine intake	1.1	1.3	6.1	-0.5	0.2	0.4	-1.1	-0.6	-1.7	2.5	0.7	1.8	0.4	0.8	0.3	-1.4
Mouth/teeth dental problems	1.1	1.7	4.9	1.7	0.5	2.2	1.4	2.0	1.0	0.4	1.2	-0.1	0.5	1.0	1.3	1.5
Father’s age at death	1.1	1.5	5.9	-0.3	0.4	-1.1	1.0	0.2	1.5	-2.4	-1.8	0.6	-1.6	-0.6	-0.3	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	6.1	1.1	1.2	2.2	1.1	1.2	1.9	-2.5	0.2	0.1	0.5	0.0	0.6	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	6.3	-0.7	0.2	-1.0	-1.0	-0.8	-2.1	2.5	-0.0	1.3	-0.3	-0.9	-0.4	-0.9
Shortness of breath walking on level ground	1.1	1.3	3.7	1.2	-0.6	1.8	-0.2	0.7	0.8	-0.5	1.2	0.3	1.9	1.5	1.8	-0.2
Eye problems/disorders: None of the above	1.1	1.3	3.9	-1.4	-0.4	-1.1	-1.3	-1.8	-1.2	0.3	-0.5	0.1	-0.0	-0.6	-1.6	-2.0
Pulse rate, automated reading	1.1	3.5	22.6	0.4	0.8	0.9	1.1	0.5	3.1	-4.8	-0.9	-0.3	0.1	-2.4	0.6	1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.0	0.7	-0.6	0.6	-1.0	-1.0	0.6	-1.4	0.8	1.2	1.8	-0.2	2.0	-1.0
Smoking status: Previous	1.1	1.7	5.2	1.0	1.2	0.2	-1.2	0.3	-1.3	2.3	1.7	0.3	1.8	1.5	1.0	-1.1
Commuting to job workplace: Public transport	1.1	1.3	3.5	-1.3	0.2	-1.2	-1.5	-0.7	-1.8	1.9	-0.7	0.7	-0.7	-0.1	-1.5	-0.6
Pack years of smoking	1.1	1.7	7.8	-1.2	-2.8	-0.9	0.8	-0.7	-0.3	-0.5	-1.3	-2.0	-1.2	-1.6	-0.1	0.4
Ulcerative Colitis (UC)	1.0	1.9	4.4	2.0	1.1	1.4	1.2	2.1	1.2	-0.2	1.3	0.2	0.9	1.4	1.4	1.9
Reaction Time	1.0	1.9	5.8	-0.6	-0.2	-0.8	-2.4	-1.7	-2.0	1.7	0.9	0.3	1.4	0.2	0.6	-2.1
Hypothyroidism (self reported)	1.0	2.2	7.7	-0.9	0.4	-1.2	-2.8	-1.5	-1.7	1.5	0.2	2.0	1.6	-0.1	-0.5	-2.0
Chronotype (morning person)	1.0	2.3	7.4	-0.8	0.2	0.2	-1.7	-1.3	-2.3	2.6	1.0	0.7	0.6	1.5	-1.4	-2.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.0	0.6	-1.7	0.9	1.6	0.9	0.9	-0.6	-0.2	-0.5	-0.9	0.2	0.8	1.7
Medication: Levothyroxine sodium	1.0	1.6	5.2	-0.4	-0.0	-1.3	-2.3	-1.1	-1.5	1.5	0.6	0.6	1.7	0.2	0.5	-2.1
High blood pressure (mother)	1.0	1.4	4.8	0.9	-0.4	0.8	1.8	1.6	1.6	-1.2	-0.4	-0.9	-0.9	0.3	-0.6	2.2
Past tobacco smoking	1.0	1.8	6.6	0.4	-0.4	0.7	1.7	1.2	2.4	-2.6	-0.8	-0.1	-1.0	-0.7	-0.6	1.8
Illnesses of siblings	1.0	1.4	4.1	-1.1	-0.7	-0.6	0.9	-0.5	0.4	-1.4	-1.9	-0.8	-2.0	-1.8	-0.8	1.0
Trunk fat-free mass	1.0	6.0	13.8	-2.6	-3.1	-2.7	0.2	-1.1	-1.3	1.1	-3.7	-2.5	-3.6	-2.0	-3.6	0.3
Mouth/teeth dental problems: Dentures	1.0	1.7	4.8	1.3	1.8	-0.1	-0.9	0.5	0.4	-0.0	1.8	1.1	2.2	1.6	1.8	-0.5
Trunk predicted mass	1.0	5.8	13.8	-2.5	-3.0	-2.6	0.3	-1.0	-1.2	1.1	-3.7	-2.5	-3.5	-2.0	-3.7	0.4
Blood clot in the leg (DVT)	1.0	1.3	5.4	0.3	0.5	0.6	-1.6	-0.4	-0.2	0.3	1.6	-0.3	2.3	1.2	0.7	-1.9
Leg pain on walking	1.0	1.2	4.0	0.7	1.1	0.3	-1.6	0.0	-0.1	0.2	1.2	1.8	2.0	1.1	0.7	-1.1
Illnesses of father: Heart disease	1.0	1.4	3.6	-1.5	-1.2	-1.2	-0.3	-1.1	-1.2	1.0	-1.0	-1.9	-1.4	-0.6	-1.2	-0.8
Mood swings	1.0	1.9	5.2	1.7	1.6	1.5	-0.1	1.2	1.2	-0.8	1.6	1.5	2.3	0.8	1.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	3.8	-0.2	0.9	1.1	0.0	-0.1	-1.1	2.0	1.0	1.1	0.7	0.7	-1.0	-1.5
Medication for cholesterol	1.0	1.5	3.1	-1.8	-0.1	-1.6	-0.9	-1.7	-0.8	-0.3	-1.3	1.4	-1.0	-0.8	-1.8	-1.3
Breast cancer (self-reported)	1.0	1.1	6.2	0.8	1.1	0.8	-0.0	0.1	0.2	-0.4	0.9	1.7	1.1	-0.9	2.5	0.1
Hearing aid user	1.0	1.2	3.3	-0.4	-1.8	-0.4	0.7	0.3	0.4	-0.3	-1.5	-1.0	-1.6	-1.6	-1.0	1.1
Heart disease (siblings)	1.0	1.2	3.8	0.6	1.4	1.0	-0.7	-0.4	0.0	-0.0	1.4	1.4	1.9	0.8	1.4	-1.1
Depression (Nagel 2018)	0.9	1.3	3.1	1.3	1.1	1.3	0.2	0.7	1.7	-1.8	0.7	1.3	1.5	0.2	1.0	0.2
Body Mass Index (BMI) (2010)	0.9	1.2	3.1	-0.5	-1.7	-1.4	0.5	0.1	-1.0	1.5	-0.9	-1.8	-1.3	-0.6	0.2	0.6
Mean Putamen Volume	0.9	1.0	4.0	-0.9	-1.2	-1.2	0.4	-0.4	-0.2	-0.2	-1.2	-2.0	-1.5	-1.2	-0.2	0.5
Fasting Glucose	0.9	1.0	3.0	1.1	0.3	1.5	0.9	0.5	1.4	-1.7	0.5	0.8	1.1	1.1	0.5	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.1	1.1	1.3	1.2	-0.4	0.7	0.6	-0.0	1.6	1.1	2.0	1.2	-0.1	-0.7
Impedance of leg (left)	0.9	4.3	9.4	2.9	2.6	2.1	0.1	2.0	0.8	0.6	3.1	2.0	2.6	2.3	2.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	4.8	0.9	-0.2	-0.0	-1.7	0.2	-0.9	1.8	0.8	-0.2	1.1	0.3	2.2	0.0
Depression (self-reported)	0.9	1.1	5.6	-1.3	-1.0	-0.7	-0.1	-1.2	-0.5	-0.6	-1.1	-0.4	-1.1	-2.4	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	9.4	-0.5	-2.1	-0.3	1.4	0.6	0.2	0.3	-2.5	-2.0	-3.1	-1.6	-0.8	2.3
Loud music exposure frequency	0.9	1.0	3.3	1.1	1.1	0.4	0.0	1.1	0.2	0.8	1.4	-0.5	1.5	1.8	-0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.9	-1.0	-0.2	-1.1	-2.4	-1.5	-1.8	1.7	0.1	0.4	1.2	-0.2	-0.4	-1.9
Medication: Amlodipine	0.9	1.3	5.2	1.5	0.7	0.9	-0.8	0.7	0.3	0.3	1.5	0.5	2.3	1.6	1.2	-0.7
Birth weight	0.9	2.0	8.3	0.0	-0.8	-0.8	1.7	0.6	1.1	-0.9	-1.7	-2.9	-1.8	-0.6	-0.1	2.1
Forced vital capacity (FVC), Best measure	0.9	3.2	11.2	-0.4	-2.2	-0.2	1.8	0.8	0.0	0.8	-2.6	-2.3	-3.4	-1.2	-1.1	2.3
Medication: Seretide 50 evohaler	0.9	1.1	3.4	-1.1	-1.4	-1.0	-0.5	-0.8	0.4	-1.8	-1.1	0.0	-0.5	-1.7	0.4	0.5
Arm predicted mass (right)	0.9	4.6	10.7	-2.2	-3.1	-2.5	-0.2	-1.0	-1.2	0.9	-3.3	-1.9	-2.9	-2.2	-3.0	0.3
Whole body fat-free mass	0.9	5.0	11.6	-2.4	-3.0	-2.7	-0.1	-1.1	-1.1	0.9	-3.4	-2.2	-3.0	-2.0	-3.1	0.2
Osteoarthritis (self-reported)	0.9	1.2	6.2	-0.5	-0.9	-0.8	-1.5	-1.1	-0.5	-0.4	0.1	-0.7	0.7	-1.4	2.5	-0.5
Average weekly champagne plus white wine intake	0.9	1.2	3.7	-0.8	-0.1	-1.9	-1.2	-0.7	-1.7	1.8	-0.3	-1.2	-0.7	-1.3	-0.3	-0.4
Eye problems/disorders: Glaucoma	0.9	1.1	3.0	1.2	0.3	0.8	-1.0	0.7	-0.6	1.7	1.3	-1.0	1.6	0.6	1.3	-0.0
Medication: Blood pressure	0.9	1.8	4.0	1.9	-0.1	1.9	0.3	1.4	0.6	0.4	1.8	-0.4	1.3	2.0	2.0	0.6
Ever smoked	0.9	1.5	4.5	-0.5	0.4	-0.9	-1.2	-1.2	-2.0	2.1	1.0	-0.8	1.0	0.7	0.2	-2.0
Diastolic blood pressure, automated reading	0.9	2.8	5.8	2.2	0.4	1.6	1.2	2.4	2.2	-1.5	1.3	-0.8	1.0	1.2	2.0	2.3
Pain experienced in last month	0.9	1.5	6.4	-1.1	-1.4	-0.5	1.5	-0.1	0.2	-0.6	-1.7	-0.2	-2.5	-0.4	-1.6	0.8
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.1	-0.2	-0.9	0.7	1.1	0.2	1.0	-1.4	-1.2	0.0	-1.4	-1.0	0.4	1.4
Supplements: Zinc	0.8	0.9	2.5	-1.1	-0.7	-0.1	-1.6	-1.5	-1.4	0.8	-0.4	0.5	-0.2	-0.8	-0.3	-1.1
Arm fat-free mass (right)	0.8	4.1	10.1	-2.1	-2.8	-2.2	-0.0	-0.9	-1.0	0.8	-3.2	-1.9	-2.8	-2.0	-2.9	0.4
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.5	-0.5	-1.2	-0.5	-0.3	-0.1	0.6	-1.2	-1.4	-1.6	-1.0	-1.4	-0.6	0.5
Mineral and other dietary supplements	0.8	1.1	3.8	0.8	1.0	1.1	1.9	1.0	1.7	-1.6	-0.1	0.3	-0.4	0.0	-0.8	0.7
Whole body water mass	0.8	4.8	11.4	-2.2	-2.9	-2.6	-0.1	-1.0	-1.1	0.9	-3.4	-2.3	-3.0	-1.9	-3.1	0.3
Number of self-reported non-cancer illnesses	0.8	1.5	6.2	0.9	0.4	0.7	-1.9	0.3	0.1	0.2	1.8	0.6	2.5	0.2	1.8	-0.8
Illnesses of father: High blood pressure	0.8	0.9	2.6	1.2	0.8	1.1	1.0	1.6	0.7	0.3	0.9	-1.0	0.3	-0.4	0.9	1.3
Arm fat-free mass (left)	0.8	4.1	10.4	-1.9	-2.9	-2.5	0.2	-0.6	-0.6	0.5	-3.2	-2.1	-2.8	-2.0	-2.6	0.8
Arm predicted mass (left)	0.8	4.0	10.3	-1.9	-2.9	-2.3	0.1	-0.7	-0.7	0.6	-3.2	-2.0	-2.8	-2.1	-2.6	0.7
Alzheimer’s Disease (including proxy)	0.7	1.1	4.8	0.2	-0.5	0.9	1.2	0.5	1.5	-2.2	-0.3	-1.6	-1.0	-0.1	-0.7	0.5
Prostate Cancer	0.7	1.0	3.5	1.0	0.4	1.3	0.9	1.0	0.2	0.5	1.6	0.8	0.6	1.1	1.9	0.5
Bipolar Disorder (2011)	0.7	0.6	4.2	0.8	0.0	0.7	0.0	0.5	0.6	-0.6	1.0	0.0	0.8	0.5	2.0	0.5
Medication for hormone replacement therapy	0.7	0.8	2.1	0.9	1.4	0.5	1.1	1.3	1.3	-0.7	0.6	-1.0	0.5	0.2	-0.5	0.7
Diabetes (father)	0.7	0.8	4.5	0.2	1.2	0.1	-0.5	0.3	-0.3	1.1	0.5	2.1	0.3	1.3	-0.8	-0.5
Trunk fat percentage	0.7	3.0	10.2	1.2	0.2	-0.2	-2.7	-0.0	-0.6	0.9	2.0	2.1	3.2	0.8	3.0	-1.0
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.3	1.0	0.3	2.0	1.6	1.3	2.0	-2.1	0.0	-0.1	-0.1	1.1	-0.5	1.0
Time employed in main current job	0.7	0.8	1.9	0.1	-0.1	0.4	1.3	0.1	1.0	-1.3	-1.0	-0.6	-1.4	0.2	-1.1	0.7
Pulse rate	0.7	1.2	5.8	-0.3	-0.8	0.5	1.4	0.0	0.8	-1.4	-0.8	-2.4	-0.8	-0.9	0.8	1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.3	-1.3	0.1	-0.9	-1.8	-1.4	-0.9	0.2	-0.1	-0.7	0.1	0.1	-0.8	-1.6
High blood pressure (siblings)	0.7	1.0	3.3	1.3	0.6	1.2	0.1	0.8	-0.1	1.0	1.8	-0.0	1.4	1.7	0.6	-0.5
Medication: Blood pressure	0.7	1.3	2.5	1.5	1.1	0.4	1.4	1.6	1.6	-1.0	1.0	0.7	0.9	0.9	0.9	1.2
Heart disease (mother)	0.7	0.9	1.7	-0.3	-1.2	-1.2	0.6	0.2	0.8	-1.3	-1.1	-1.0	-1.0	-0.7	-0.4	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.4	-0.7	-0.0	0.5	1.5	0.5	0.8	-1.0	-0.8	-0.6	-1.6	-0.5	-1.4	1.1
Medication: Gliclazide	0.7	0.8	2.3	1.5	0.2	1.5	0.1	0.9	1.0	-0.6	1.0	-1.2	1.3	0.2	0.4	0.1
Illnesses of father: None of the above (group 1)	0.7	0.8	3.4	-0.1	0.5	-0.2	-1.2	-0.7	-1.3	1.4	0.7	1.9	0.5	0.5	0.8	-0.5
Basal metabolic rate	0.7	3.8	8.7	-2.1	-2.9	-2.5	-0.5	-1.0	-1.1	0.9	-3.0	-1.9	-2.4	-1.9	-2.4	0.1
Age started oral contraceptive pill	0.7	0.8	2.5	-0.3	-0.6	-0.1	0.7	-0.1	0.8	-1.6	-1.2	-0.9	-1.2	-1.4	-0.6	0.7
Supplements: Calcium	0.7	0.8	2.7	-0.1	0.3	0.6	-1.1	-0.2	-0.8	1.4	0.9	-0.1	1.2	1.6	0.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.6	0.1	0.2	0.4	-1.3	-0.4	-0.1	0.0	1.2	-0.5	1.9	1.0	0.4	-1.7
Schizophrenia vs Biploar Disorder	0.6	0.8	4.1	0.5	0.0	0.0	0.0	0.1	-1.1	2.0	1.1	0.0	0.8	0.7	1.5	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	1.5	0.9	0.6	1.2	1.1	0.9	0.9	-0.3	1.0	-0.8	0.5	1.0	0.4	-0.0
Crohns Disease (2017)	0.6	1.3	4.1	1.3	1.4	1.2	-0.7	0.6	0.5	-0.1	1.9	0.7	2.0	0.8	1.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.6	-1.7	-0.1	0.0	-1.4	-1.9	-1.8	0.9	-0.1	-1.7	0.0	-0.4	-0.9	-1.8
Blood White Count	0.6	4.5	13.8	2.7	2.1	1.8	-0.7	1.5	2.1	-1.7	3.5	0.1	3.7	2.3	0.9	-1.2
Ever had hysterectomy (womb removed)	0.6	0.6	2.6	-0.7	-0.5	-0.8	0.4	-0.3	0.2	-0.8	-1.2	-0.1	-1.2	-1.6	0.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.8	1.3	1.2	0.6	0.4	0.5	1.2	-1.1	0.6	0.5	1.1	-0.4	0.9	0.4
Leg predicted mass (left)	0.6	3.1	7.1	-1.9	-2.6	-2.2	-0.6	-1.1	-0.9	0.6	-2.7	-1.7	-2.0	-1.6	-2.2	-0.1
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	-1.2	-1.5	-0.5	-0.3	-0.9	-0.6	-0.1	-1.1	-0.2	-1.0	-0.1	-1.3	-0.7
Heart attack	0.6	0.8	2.2	0.8	1.0	0.4	-0.7	0.9	-0.3	1.5	0.9	1.1	1.2	0.8	0.5	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	7.1	-0.5	-1.5	0.3	1.4	0.6	0.6	-0.2	-2.2	-1.1	-2.7	-1.1	-0.4	2.2
Lung cancer (father)	0.6	0.7	2.5	0.1	0.5	-0.2	-1.5	-0.1	-0.0	-0.1	1.0	1.6	1.4	0.7	-0.4	-0.9
Birth weight of first child	0.6	1.1	5.2	1.2	1.3	-0.2	1.3	2.3	1.0	0.6	0.6	-0.8	-0.2	0.6	-0.8	1.3
Medication: Paracetamol	0.6	1.1	7.2	0.6	-0.0	1.3	-1.1	-0.2	-0.0	-0.1	1.0	-0.4	1.5	0.1	2.7	-0.1
Body fat percentage	0.6	2.3	7.7	1.0	-0.1	-0.3	-2.5	-0.1	-0.4	0.6	1.6	1.9	2.8	0.5	2.7	-0.8
Knee pain experienced in last month	0.6	1.0	2.8	-1.1	-1.0	-0.9	-1.7	-1.4	-1.1	0.3	-0.3	-1.5	0.1	-0.8	0.2	-1.0
Arm fat percentage (left)	0.6	2.3	7.8	0.4	-0.4	-0.6	-2.8	-0.8	-0.9	0.9	1.3	1.5	2.5	0.2	2.6	-1.3
Loneliness, isolation	0.6	0.9	3.5	-1.0	0.4	-0.7	-0.5	-1.1	-1.2	0.5	0.0	-0.9	-0.0	-1.9	-0.7	-1.4
Ever had bowel cancer screening	0.6	0.7	1.7	0.6	1.1	0.6	-0.7	0.1	0.1	0.3	1.3	0.8	1.3	0.9	1.1	-0.4
Friendships satisfaction	0.6	0.8	2.9	-1.2	0.2	-0.5	-0.9	-1.6	-1.7	1.0	0.1	0.2	-0.1	0.5	0.7	-0.9
Commuting to job workplace: Walk	0.6	0.7	2.6	-0.9	0.1	-1.2	-0.3	-0.2	-0.3	0.1	-0.7	-1.6	-0.6	0.2	-1.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.9	-0.3	-1.1	0.6	0.7	0.5	1.0	-1.0	-1.9	-0.5	-2.0	-1.2	-0.5	1.9
Medication: Paracetamol	0.6	0.9	6.3	0.0	-0.7	0.5	-1.6	-0.7	-0.3	-0.2	0.3	-0.5	0.8	-0.5	2.5	0.0
Alcohol drinker status: Never	0.6	0.7	3.6	-0.4	0.4	0.7	0.3	-0.2	1.1	-1.9	-1.1	0.7	-0.9	-0.5	-0.2	1.1
Unable to work because of sickness or disability	0.6	0.8	3.7	-1.1	-0.8	-0.3	-0.9	-1.1	-1.1	0.2	-0.1	0.1	0.1	-1.9	0.8	-0.7
Cholesterol lowering medication	0.6	0.8	3.2	-0.2	-1.8	-0.4	-1.0	-0.7	-0.6	0.0	-0.2	-0.8	0.4	-1.8	1.4	-0.1
LDL Cholesterol	0.5	0.8	2.5	1.1	1.1	1.6	0.2	1.1	0.9	-0.2	0.9	0.8	0.9	1.0	0.7	0.2
Hearing difficulty/problems: Yes	0.5	0.7	2.4	0.6	1.3	0.3	-0.7	0.6	0.1	0.6	1.5	0.6	1.2	0.9	0.3	-0.6
Relative age of first facial hair	0.5	1.1	4.5	-0.7	-0.7	-1.5	-0.1	-0.4	0.2	-1.2	-0.9	-2.1	-0.6	-1.5	-1.3	0.4
Leg fat-free mass (left)	0.5	2.8	6.7	-1.8	-2.5	-2.1	-0.6	-1.0	-0.9	0.6	-2.6	-1.7	-1.9	-1.6	-2.2	-0.0
Relative age voice broke	0.5	0.8	3.4	0.0	-1.4	0.1	0.8	-0.3	0.2	-1.0	-0.8	-1.4	-0.3	-1.8	0.0	0.5
Waist circumference	0.5	1.7	6.6	-0.5	-1.5	-1.4	-2.6	-1.2	-1.5	1.2	0.2	0.1	1.5	-0.6	1.3	-1.4
Number of incorrect matches in round	0.5	0.8	2.3	0.7	-0.1	0.1	1.0	1.0	1.5	-1.5	0.4	0.6	0.5	-0.3	0.8	1.4
Had menopause	0.5	0.7	2.1	1.1	0.8	0.9	0.2	0.5	0.1	0.5	1.4	-0.3	1.2	1.0	0.6	-0.6
Had other major operations	0.5	0.6	2.4	0.9	0.5	0.9	-0.2	0.1	-0.5	0.8	1.0	0.8	1.1	0.1	1.6	-0.5
Forced vital capacity (FVC)	0.5	1.9	7.6	-0.6	-1.8	0.1	1.1	0.5	-0.1	0.5	-2.3	-1.4	-2.8	-1.0	-0.4	1.9
Fluid intelligence score	0.5	1.0	5.2	-1.3	0.0	-0.2	-0.7	-1.1	-0.9	0.3	-0.4	-2.3	-0.5	-0.2	-1.2	-1.2
Breastfed as a baby	0.5	0.6	3.6	-0.5	0.9	-0.1	0.2	-0.2	-0.3	0.8	-0.2	0.7	-0.4	1.1	-1.9	-1.0
Peak expiratory flow (PEF)	0.5	1.2	3.6	0.4	-0.2	1.9	1.4	1.2	1.2	-0.8	-1.1	0.0	-1.3	-0.2	0.3	1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	0.8	0.7	1.4	-0.0	0.4	0.8	-1.0	0.5	0.8	0.8	0.2	1.2	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	0.1	-0.4	-0.5	-1.0	-0.5	-0.5	0.4	1.0	-1.1	1.2	0.7	-0.0	-1.3
Number of children fathered	0.5	0.6	2.1	0.1	0.1	0.5	0.1	-0.1	-0.7	1.0	0.9	0.2	0.7	1.5	1.4	-0.3
Emphysema/chronic bronchitis	0.5	0.6	3.5	-0.3	-0.3	0.7	0.1	-0.5	-0.5	0.4	0.5	-1.9	0.2	0.3	-0.9	-1.4
Medication: Allopurinol	0.5	0.6	4.2	0.3	0.5	0.5	-0.7	-0.4	-0.4	0.6	0.3	2.0	0.8	1.0	0.2	-0.4
Smoking status: Current	0.5	0.7	2.0	-0.8	-1.2	-1.1	0.5	-0.4	0.0	-0.4	-1.0	-1.4	-0.9	-0.4	-1.3	-0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.8	-0.2	-1.1	-0.9	-1.7	-0.4	-0.7	0.6	-0.3	-1.0	0.5	-0.2	1.1	-0.2
Number of operations (self-reported)	0.5	0.7	2.1	-1.0	-0.6	-0.9	-0.7	-1.3	-0.4	-0.7	-0.1	0.8	0.3	-0.8	-0.0	-1.5
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.7	0.8	1.1	0.5	-0.6	0.9	-0.2	1.3	0.9	0.9	1.1	0.7	0.3	0.1
Alcohol drinker status: Previous	0.5	0.6	2.1	0.1	1.2	0.6	0.9	1.2	0.8	-0.6	-0.2	-0.1	-0.5	-0.2	-0.0	1.4
Crohns Disease (2012)	0.4	0.7	2.0	1.0	0.0	1.3	0.0	1.1	1.4	-1.3	0.1	0.0	0.4	-0.0	0.4	1.2
Lupus	0.4	0.7	2.6	1.3	0.2	1.6	0.5	1.2	0.6	-0.0	1.0	0.3	0.8	-0.3	0.2	0.6
Rheumatoid Arthritis	0.4	0.5	1.9	0.6	-0.1	0.5	0.7	0.9	1.2	-0.9	-0.5	0.0	-0.6	-0.5	-0.1	1.4
BMI	0.4	2.5	8.4	-1.8	-2.9	-2.2	-1.4	-1.7	-1.8	0.9	-1.4	-0.9	-0.8	-1.8	0.6	-0.3
Cardiovascular Disease	0.4	1.3	4.5	1.3	-0.9	0.7	1.1	1.2	1.2	-0.6	0.7	-1.3	0.5	0.1	2.1	1.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	1.0	-0.4	0.8	-0.2	0.6	1.1	-0.9	0.4	-0.4	0.8	-0.1	0.4	0.6
Diabetes (mother)	0.4	0.5	3.7	-0.2	-0.2	-0.1	0.3	-0.1	1.3	-1.9	-0.7	0.2	-0.0	-0.5	0.0	0.5
Impedance of leg (right)	0.4	2.1	4.7	2.2	1.8	1.6	0.5	1.6	0.7	0.3	1.9	1.4	1.7	1.4	1.6	0.8
Townsend deprivation index at recruitment	0.4	0.6	2.7	0.3	-0.2	-0.2	0.8	0.9	0.9	-0.9	-0.4	-0.5	-0.6	-1.2	0.3	1.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.7	-1.1	-0.0	-0.5	-0.3	-0.9	-0.8	0.4	-0.5	1.3	-0.6	-0.4	-0.1	-0.6
Financial difficulties in last 2 years	0.4	0.5	1.9	0.3	0.4	0.2	-0.4	-0.0	-0.8	1.2	1.4	-0.6	1.1	0.1	0.9	-0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	3.4	0.1	-0.5	-0.4	-0.4	0.5	0.1	0.1	-0.5	-1.8	-0.5	0.3	-1.0	0.5
Arm fat percentage (right)	0.4	1.7	6.0	0.5	-0.4	-0.4	-2.3	-0.5	-0.6	0.6	1.1	1.4	2.2	0.2	2.5	-0.9
Hip circumference	0.4	1.6	7.2	-0.9	-0.6	-1.6	-2.7	-1.1	-1.5	1.5	-0.0	0.7	1.0	0.1	-0.2	-1.5
Prospective memory result	0.4	0.4	2.1	-0.5	-0.3	-0.5	-0.9	-1.5	-0.6	-0.1	-0.2	-0.3	0.2	-0.3	-0.3	-1.3
Number of full brothers	0.4	0.5	1.3	-0.4	-1.0	-0.8	0.7	-0.2	0.6	-1.1	-0.8	-0.4	-0.6	-0.8	-0.3	0.3
Worry too long after embarrassment	0.4	0.8	4.0	-0.0	0.5	0.2	-0.9	-0.2	-1.4	2.0	0.9	-0.1	0.5	0.4	0.8	-0.9
Had major operations	0.4	0.5	1.3	-0.9	-0.5	-1.1	-0.2	-0.8	0.2	-1.1	-0.6	0.0	-0.2	-0.5	-1.1	-0.5
Leg fat-free mass (right)	0.4	2.3	5.2	-1.7	-2.3	-2.0	-0.7	-0.9	-1.0	0.8	-2.2	-1.5	-1.6	-1.2	-2.0	-0.2
Osteoporosis (self-reported)	0.4	0.6	1.9	0.1	1.3	1.4	0.4	-0.1	0.1	-0.1	1.2	0.8	0.7	0.7	0.2	-0.6
Leg predicted mass (right)	0.4	2.3	5.1	-1.7	-2.2	-2.0	-0.7	-0.9	-0.9	0.8	-2.2	-1.6	-1.7	-1.2	-2.0	-0.2
Financial situation satisfaction	0.4	0.5	2.2	0.3	-0.8	0.6	0.3	0.3	0.8	-1.3	0.5	-0.5	0.8	-0.4	1.5	0.4
Leg fat percentage (left)	0.4	1.5	5.1	0.4	-0.9	-0.7	-2.3	-0.4	-0.5	0.4	1.0	1.4	2.1	0.1	2.2	-0.7
Average weekly beer plus cider intake	0.4	0.6	2.0	0.3	-0.1	0.9	0.8	0.8	1.4	-1.2	-0.0	1.1	-0.1	-0.0	0.4	1.1
Major Depression (MDD)	0.3	0.3	0.8	0.9	-0.0	0.6	0.7	0.8	0.3	0.2	0.8	0.0	0.7	-0.6	0.5	0.7
Coronary Artery Disease (CAD)	0.3	0.3	1.7	-0.6	0.0	-0.4	0.8	-0.4	-0.1	-0.4	-0.7	0.0	-0.5	-1.3	0.5	0.4
Waist Hip Ratio (WHR)	0.3	1.2	5.2	-0.4	-2.3	-0.5	0.2	-1.0	-0.3	-0.7	-1.0	-1.9	-0.5	-1.4	1.3	-0.0
Respiratory disease	0.3	0.7	3.2	-0.9	-0.8	-0.7	-0.8	-0.9	0.1	-1.1	-0.4	-1.8	0.4	-0.4	-0.6	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.0	0.3	0.6	0.3	0.0	-0.4	0.6	-1.4	0.2	0.7	0.9	-0.8	0.6	-0.2
Current tobacco smoking	0.3	0.5	2.2	-0.5	-0.8	-0.8	0.7	0.1	0.5	-0.7	-0.6	-1.5	-0.5	-0.1	-1.0	0.1
Age when periods started (menarche)	0.3	0.6	2.7	-0.4	0.2	-0.0	1.0	-0.1	1.1	-1.7	-0.7	-1.1	-0.8	-0.0	-0.9	0.2
Sitting height	0.3	1.9	8.2	-0.4	-0.6	-0.6	1.5	0.6	-0.1	1.0	-2.0	-0.4	-2.4	0.9	-2.9	0.8
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	-0.2	0.3	1.0	-0.5	-0.8	-0.1	-0.3	0.1	-1.0	0.7	-0.2	0.4	-0.8
Body mass index (BMI)	0.3	1.5	4.8	-0.9	-2.0	-1.4	-2.2	-1.3	-1.1	0.5	-0.3	-0.0	0.8	-1.2	1.2	-0.9
Trunk fat mass	0.3	1.2	4.3	0.5	-0.5	-0.8	-2.1	-0.1	-0.7	1.0	0.7	1.4	1.8	0.2	1.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	-0.3	-0.9	0.9	0.3	-0.2	-0.4	0.2	-0.7	-1.0	-0.8	-0.3	-0.9	0.3
Allergy	0.3	0.6	2.0	-0.3	0.2	-1.4	0.4	-0.1	-1.0	1.4	-0.4	0.5	-1.0	-1.0	-0.1	0.6
Weight	0.3	1.3	4.2	-1.0	-2.1	-1.8	-1.5	-0.8	-1.0	0.9	-1.3	-0.4	-0.4	-1.0	-0.4	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	-0.8	-1.1	-0.5	-0.0	-0.9	-0.1	-0.4	-0.8	-0.2	-0.7	-0.5	-0.7	-0.3
Happiness	0.3	0.3	1.2	-0.6	0.8	-0.0	-0.3	-1.0	-0.3	-0.5	0.4	-0.1	0.3	0.1	-0.7	-1.1
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.2	0.8	0.4	-0.3	0.0	0.1	0.2	1.0	-0.2	1.0	0.7	0.2	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.8	0.9	1.3	1.7	0.9	0.9	0.7	-0.5	0.7	1.1	0.6	0.4	0.7	0.2
Leg fat percentage (right)	0.3	1.2	4.3	-0.1	-1.4	-0.9	-2.1	-0.7	-0.6	0.2	0.4	1.0	1.5	-0.5	1.9	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	0.0	0.0	0.9	1.0	0.4	0.8	-1.1	-0.2	-0.6	-0.0	-0.2	-0.7	0.8
Wheeze or whistling in the chest in last year	0.3	0.6	3.3	-0.3	-0.5	0.1	-1.8	-0.6	-0.4	0.2	0.3	0.4	1.2	-0.5	-0.3	-1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.8	-0.5	0.7	0.6	-0.8	-0.3	-0.4	0.3	0.6	1.3	0.1	0.3	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.7	-0.2	-0.7	-1.3	-0.6	-0.1	-0.9	1.6	-0.4	-0.3	-0.4	-0.1	-1.1	-0.5
Handedness (chirality/laterality): Left-handed	0.3	0.4	2.1	-0.5	-0.7	-0.2	-0.0	-0.5	-0.6	0.4	-0.4	1.4	-0.6	-0.3	0.9	0.2
Asthma (self-reported)	0.3	0.5	2.4	-0.3	0.2	-0.2	-1.6	-0.6	-0.1	-0.4	0.5	-0.4	1.2	0.3	0.0	-1.3
Medication: Aspirin	0.3	0.5	1.5	-0.2	-0.7	-0.5	-1.2	-0.8	-0.1	-0.3	0.0	-0.5	0.8	-0.5	-0.3	-1.2
Arm fat mass (left)	0.3	1.3	5.1	-0.3	-1.4	-1.2	-2.3	-0.9	-1.1	1.0	0.1	0.4	1.2	-0.5	1.5	-0.8
Miserableness	0.3	0.5	2.4	-0.3	0.1	-0.1	0.5	-0.2	0.0	-0.9	-0.3	-0.6	-0.3	-1.4	1.6	0.8
Wears glasses or contact lenses	0.3	0.4	1.0	-0.3	0.7	-0.9	-1.0	-0.5	-0.6	0.4	0.0	-1.0	-0.0	-0.4	-0.4	-0.7
Ever taken oral contraceptive pill	0.3	0.3	1.0	-0.1	0.3	0.3	-0.3	-0.2	-0.7	1.0	0.6	-0.6	0.3	-0.0	-1.0	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.8	0.4	-0.2	-0.0	1.0	0.8	-0.3	0.8	0.2	0.7	0.1	1.0	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.7	1.0	0.1	-0.1	-0.6	0.9	0.1	0.2	0.9	0.5	1.3	0.1	0.8	0.2
High cholesterol (Self-reported)	0.3	0.6	3.9	0.7	-0.7	-0.7	-0.4	0.0	0.5	-0.8	0.3	-0.0	0.8	-0.9	2.0	0.4
Medication: Bendroflumethiazide	0.3	0.4	1.4	-0.4	-1.0	-0.8	0.1	-0.4	-0.3	-0.3	0.0	-1.1	-0.3	0.2	1.2	0.5
Risk taking	0.3	0.4	1.3	0.0	-0.8	0.2	-0.4	0.4	-0.6	1.0	-0.3	-0.2	-0.3	-1.1	0.5	0.8
Ever depressed for a whole week	0.3	0.4	0.8	0.4	0.7	0.5	0.6	0.7	0.7	-0.8	-0.3	-0.6	-0.5	-0.3	-0.9	0.8
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	0.9	0.6	0.8	0.1	0.4	1.0	-1.2	0.4	0.2	0.9	-0.7	0.4	0.2
Breast Cancer	0.2	0.6	1.3	-0.8	-0.4	-1.1	-0.5	-1.1	-1.0	0.8	-0.9	-0.8	-0.5	-0.5	0.4	-0.5
Primary Biliary Cirrhosis	0.2	0.3	1.4	0.5	-0.2	0.0	0.0	0.8	0.8	-0.3	0.0	-0.9	-0.0	0.5	-1.2	0.3
Severe depression (siblings)	0.2	0.2	1.1	0.3	-0.3	-0.1	-0.7	-0.4	-0.4	0.4	-0.6	-0.4	-0.1	-1.0	0.5	-0.2
Medication: Ramipril	0.2	0.3	0.7	0.5	-0.2	0.5	-0.3	0.8	0.7	-0.4	-0.1	0.3	0.2	0.6	0.5	0.8
Number of live births	0.2	0.3	1.0	-0.5	-1.0	-0.7	-0.7	-1.0	-0.5	-0.4	-0.1	0.3	0.2	-0.1	0.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	0.1	1.1	-0.4	0.4	0.2	-0.2	0.9	0.3	-0.8	0.0	-0.0	-0.7	-0.2
Asthma	0.2	0.4	2.0	-0.5	0.1	-0.2	-1.4	-0.7	-0.2	-0.3	0.3	-0.1	0.9	0.1	-0.2	-1.2
Arm fat mass (right)	0.2	1.0	4.0	-0.2	-1.4	-1.0	-2.0	-0.7	-0.9	0.8	0.1	0.5	1.1	-0.4	1.3	-0.6
Standing height	0.2	2.2	11.0	-0.3	-0.2	-1.0	1.1	1.0	0.1	1.0	-2.1	-1.2	-2.4	0.5	-3.3	1.1
Gout (self-reported)	0.2	0.3	1.1	-0.3	-0.8	-0.2	-0.2	-0.7	-0.7	0.4	-0.7	1.1	-0.3	0.3	0.1	-0.1
Whole body fat mass	0.2	0.8	3.4	0.2	-1.0	-0.9	-1.8	-0.2	-0.5	0.8	0.3	0.9	1.3	-0.0	1.4	-0.4
Leg fat mass (right)	0.2	0.9	3.5	-0.4	-1.9	-1.3	-1.7	-0.7	-0.6	0.3	-0.5	0.2	0.7	-0.8	1.1	-0.2
Comparative height size at age 10	0.2	0.8	4.5	0.6	0.2	-0.6	0.4	1.2	0.2	1.0	-0.7	0.4	-0.6	1.4	-2.1	0.4
Chest pain or discomfort	0.2	0.3	1.1	-0.0	0.3	0.2	-0.7	-0.6	0.0	-0.9	0.2	-0.5	1.1	-0.5	0.4	-0.6
Family relationship satisfaction	0.2	0.2	1.7	-0.4	-0.3	0.5	0.1	-0.5	-0.5	0.0	0.2	-0.3	-0.1	0.6	1.3	-0.1
Medication: Aspirin	0.2	0.3	1.3	0.3	-0.2	-0.2	-0.9	-0.3	0.0	-0.1	0.3	-0.3	1.1	0.1	0.0	-1.0
Qualifications: nursing, teaching	0.2	0.4	0.9	-0.7	0.6	0.1	-0.9	-0.7	-0.8	0.6	-0.4	-0.1	-0.2	-0.3	-0.7	-0.8
Medication: Atorvastatin	0.2	0.3	0.9	-0.8	-0.0	0.5	-1.0	-1.0	-0.3	-0.2	-0.3	0.5	-0.1	-0.5	0.0	-0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.8	-0.0	0.1	0.6	0.6	0.6	-0.6	0.4	0.2	0.3	0.2	0.4	0.3
Fractured/broken bones in last 5 years	0.2	0.3	1.2	-0.6	-0.3	-0.1	-0.6	-0.8	-0.6	-0.1	0.2	0.5	0.4	-0.4	1.1	-0.3
Leg fat mass (left)	0.2	0.8	3.1	-0.2	-1.7	-1.2	-1.8	-0.5	-0.5	0.4	-0.3	0.4	0.8	-0.6	1.2	-0.1
Blood Eosinophil Count	0.1	0.5	1.9	0.3	1.1	0.0	0.5	0.1	1.1	-1.4	-0.7	-0.9	-0.3	-0.1	-0.4	0.5
Height	0.1	2.3	6.7	-0.3	-0.8	-0.3	1.7	1.0	0.7	-0.1	-2.2	-2.4	-2.5	0.0	-2.6	1.3
Smoking Status	0.1	0.2	1.2	0.4	-0.7	-0.6	0.5	0.4	0.0	0.2	-0.2	-1.1	-0.1	0.3	-0.4	0.4
Lung FEV1/FVC ratio	0.1	0.8	2.7	-0.5	-0.8	-0.4	0.8	0.1	0.9	-1.6	-1.1	-1.2	-1.1	-0.4	-0.7	0.5
Lung FVC	0.1	0.5	2.6	0.2	0.5	1.6	-0.2	0.4	-0.2	0.8	0.4	1.3	-0.1	0.2	1.0	0.6
Medication: Co-codamol	0.1	0.2	0.5	-0.0	-0.7	0.4	0.0	-0.0	0.2	-0.5	0.5	0.2	0.4	-0.4	0.6	-0.2
Fed-up feelings	0.1	0.2	0.8	0.2	0.4	0.6	0.6	0.4	0.2	-0.2	0.3	-0.9	0.2	-0.4	0.8	0.6
Back pain experienced in last month	0.1	0.2	0.9	0.6	0.7	0.9	0.1	0.2	0.3	-0.1	-0.1	0.2	0.3	-0.7	0.6	0.3
Medication: Lisinopril	0.1	0.1	0.5	-0.1	0.4	-0.7	0.1	-0.4	0.1	-0.3	0.4	-0.5	0.2	0.5	0.2	-0.2
Hair Pigment	0.0	0.4	1.7	-0.3	-1.3	-0.2	0.9	-0.6	0.2	-0.9	-0.3	0.0	-0.3	0.6	0.6	0.3
Tanning	0.0	0.3	1.3	-0.3	0.1	-0.7	-1.1	-0.6	-0.3	-0.0	-0.1	0.4	0.7	-0.1	1.0	-0.6

Hub : Genes

SPECC1

Models

Trait associations