Best TWAS P=3.53e-11 · Best GWAS P=4.16e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MARCH2 | 0.30 | 0.30 | lasso | 6 | 0.31 | 5.9e-26 | -6.6 | -6.5 | 8.9e-11 | 0.99 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | MARCH2 | 0.27 | 0.17 | lasso | 4 | 0.15 | 4.0e-08 | -6.1 | -6.2 | 4.0e-10 | 0.98 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | MARCH2 | 0.52 | 0.46 | lasso | 5 | 0.50 | 2.0e-31 | -6.6 | -6.4 | 1.4e-10 | 0.98 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Coronary | MARCH2 | 0.22 | 0.12 | lasso | 5 | 0.16 | 5.4e-06 | -6.2 | -5.5 | 4.7e-08 | 0.94 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Artery Tibial | MARCH2 | 0.36 | 0.37 | lasso | 5 | 0.44 | 5.0e-37 | -6.2 | -6.5 | 1.1e-10 | 0.97 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Brain Cerebellum | MARCH2 | 0.35 | 0.22 | lasso | 5 | 0.19 | 2.9e-06 | -6.6 | -6.5 | 9.9e-11 | 0.99 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Brain Frontal Cortex BA9 | MARCH2 | 0.48 | 0.13 | lasso | 10 | 0.14 | 1.2e-04 | -6.3 | -5.8 | 5.5e-09 | 0.93 | 0.01 | 0.97 | FALSE |
| 8 | GTEx | Brain Nucleus accumbens basal ganglia | MARCH2 | 0.30 | 0.21 | lasso | 5 | 0.28 | 3.9e-08 | -6.2 | -6.4 | 1.3e-10 | 0.97 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | MARCH2 | 0.24 | 0.13 | lasso | 7 | 0.11 | 4.6e-06 | -6.3 | -6.4 | 1.9e-10 | 0.97 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | MARCH2 | 0.26 | 0.14 | lasso | 6 | 0.11 | 3.3e-04 | -6.3 | -6.2 | 4.2e-10 | 0.95 | 0.00 | 0.98 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | MARCH2 | 0.35 | 0.27 | enet | 14 | 0.35 | 2.6e-27 | -6.6 | -5.6 | 2.1e-08 | 0.95 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Colon Sigmoid | MARCH2 | 0.33 | 0.14 | lasso | 7 | 0.25 | 2.4e-09 | -6.2 | -6.5 | 6.2e-11 | 0.91 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Esophagus Mucosa | MARCH2 | 0.42 | 0.35 | enet | 14 | 0.36 | 3.1e-25 | -6.1 | -6.2 | 6.9e-10 | 0.96 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Esophagus Muscularis | MARCH2 | 0.34 | 0.30 | enet | 22 | 0.32 | 6.9e-20 | -6.3 | -6.5 | 6.3e-11 | 0.94 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Heart Atrial Appendage | MARCH2 | 0.26 | 0.18 | enet | 36 | 0.21 | 1.2e-09 | -6.1 | -6.4 | 1.5e-10 | 0.93 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Heart Left Ventricle | MARCH2 | 0.36 | 0.26 | enet | 21 | 0.28 | 3.3e-15 | -6.1 | -6.2 | 5.3e-10 | 0.92 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Lung | MARCH2 | 0.36 | 0.25 | lasso | 8 | 0.29 | 2.8e-22 | -6.6 | -6.3 | 3.6e-10 | 0.95 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Muscle Skeletal | MARCH2 | 0.21 | 0.18 | enet | 20 | 0.19 | 2.7e-18 | -6.6 | -6.5 | 9.4e-11 | 0.96 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Nerve Tibial | MARCH2 | 0.31 | 0.32 | lasso | 5 | 0.35 | 1.3e-25 | -6.2 | -6.2 | 4.0e-10 | 0.96 | 0.01 | 0.99 | FALSE |
| 20 | GTEx | Pancreas | MARCH2 | 0.19 | 0.09 | lasso | 3 | 0.08 | 2.8e-04 | -6.1 | -5.4 | 5.7e-08 | 0.96 | 0.01 | 0.98 | FALSE |
| 21 | GTEx | Pituitary | MARCH2 | 0.46 | 0.19 | enet | 27 | 0.22 | 2.8e-06 | -6.2 | -5.4 | 6.6e-08 | 0.84 | 0.01 | 0.99 | FALSE |
| 22 | GTEx | Prostate | MARCH2 | 0.66 | 0.20 | lasso | 9 | 0.19 | 1.4e-05 | -6.2 | -6.2 | 7.1e-10 | 0.90 | 0.01 | 0.96 | FALSE |
| 23 | GTEx | Skin Not Sun Exposed Suprapubic | MARCH2 | 0.42 | 0.33 | enet | 27 | 0.35 | 5.6e-20 | -6.1 | -6.1 | 1.0e-09 | 0.94 | 0.00 | 1.00 | FALSE |
| 24 | GTEx | Skin Sun Exposed Lower leg | MARCH2 | 0.33 | 0.33 | lasso | 6 | 0.34 | 4.1e-29 | -6.6 | -6.4 | 1.8e-10 | 0.98 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | PRAM1 | 0.11 | 0.04 | lasso | 5 | 0.07 | 9.2e-07 | -6.2 | 5.5 | 5.1e-08 | -0.73 | 0.01 | 0.99 | FALSE |
| 26 | GTEx | Stomach | MARCH2 | 0.33 | 0.05 | enet | 27 | 0.11 | 6.9e-06 | -6.2 | -5.8 | 8.4e-09 | 0.80 | 0.01 | 0.99 | FALSE |
| 27 | GTEx | Testis | MARCH2 | 0.26 | 0.22 | enet | 12 | 0.22 | 6.8e-10 | -6.3 | -6.6 | 3.5e-11 | 0.97 | 0.00 | 1.00 | TRUE |
| 28 | GTEx | Vagina | MARCH2 | 0.60 | 0.05 | enet | 24 | 0.14 | 4.3e-04 | -6.2 | -5.4 | 7.5e-08 | 0.57 | 0.02 | 0.73 | FALSE |
| 29 | NTR | Blood | MARCH2 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-18 | -6.2 | -6.0 | 2.2e-09 | 0.95 | 0.01 | 0.99 | FALSE |
| 30 | NTR | Blood | PRAM1 | 0.04 | 0.02 | bslmm | 351 | 0.02 | 1.1e-06 | -6.2 | 5.5 | 3.6e-08 | -0.77 | 0.01 | 0.99 | FALSE |
| 31 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MARCH2 | 0.07 | 0.07 | blup | 42 | 0.08 | 1.4e-07 | -6.2 | -5.4 | 8.1e-08 | 0.90 | 0.01 | 0.99 | FALSE |
| 32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MARCH2 | 0.06 | 0.06 | lasso | 3 | 0.06 | 7.5e-12 | -6.3 | -6.4 | 1.6e-10 | 0.94 | 0.01 | 0.99 | FALSE |
| 33 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MARCH2 | 0.08 | 0.06 | lasso | 5 | 0.06 | 5.5e-04 | -6.6 | -6.5 | 8.5e-11 | 0.99 | 0.00 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Colon Adenocarcinoma | MARCH2 | 0.08 | 0.11 | blup | 42 | 0.08 | 1.4e-05 | -6.2 | -5.5 | 3.0e-08 | 0.88 | 0.02 | 0.98 | FALSE |
| 35 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MARCH2 | 0.10 | 0.05 | enet | 10 | 0.08 | 4.9e-09 | -6.3 | -6.5 | 8.9e-11 | 0.88 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MARCH2 | 0.11 | 0.07 | blup | 42 | 0.09 | 9.8e-06 | -6.2 | -5.4 | 8.5e-08 | 0.87 | 0.01 | 0.99 | FALSE |
| 37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MARCH2 | 0.10 | 0.10 | enet | 9 | 0.12 | 1.9e-13 | -6.2 | -6.4 | 1.7e-10 | 0.95 | 0.01 | 0.99 | FALSE |
| 38 | The Cancer Genome Atlas | Lung Adenocarcinoma | MARCH2 | 0.08 | 0.06 | lasso | 3 | 0.08 | 1.9e-09 | -6.3 | -5.8 | 6.4e-09 | 0.92 | 0.00 | 1.00 | FALSE |
| 39 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MARCH2 | 0.08 | 0.10 | enet | 5 | 0.10 | 2.6e-11 | -6.6 | -6.3 | 3.8e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 40 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MARCH2 | 0.12 | 0.13 | lasso | 1 | 0.12 | 6.5e-06 | -6.2 | -6.2 | 5.7e-10 | 0.90 | 0.01 | 0.95 | FALSE |
| 41 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MARCH2 | 0.12 | 0.15 | lasso | 4 | 0.15 | 6.9e-16 | -6.6 | -6.4 | 1.2e-10 | 0.97 | 0.00 | 1.00 | FALSE |
| 42 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MARCH2 | 0.09 | 0.10 | blup | 42 | 0.10 | 6.1e-08 | -6.3 | -5.8 | 6.8e-09 | 0.91 | 0.00 | 1.00 | FALSE |