[Hub]/) : Traits : Heel T-Score :

chr19:11,847,615-13,960,562

Best TWAS P=2.4e-13 · Best GWAS P=7.07e-15 conditioned to 0.0531

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MAN2B1 0.05 0.03 lasso 2 0.03 5.1e-05 -4.0 5.1 2.9e-07 -0.01 0.34 0.04 FALSE
2 CommonMind Brain Pre-frontal Cortex RTBDN 0.07 0.00 blup 328 0.03 8.6e-05 -2.0 7.3 2.4e-13 -0.16 0.52 0.02 TRUE
3 GTEx Artery Aorta MAN2B1 0.12 0.05 lasso 5 0.01 6.8e-02 -5.1 5.3 1.4e-07 -0.04 0.11 0.05 FALSE
4 GTEx Artery Coronary GADD45GIP1 0.40 -0.01 enet 26 0.03 4.3e-02 -2.4 -6.0 1.6e-09 0.36 0.06 0.17 FALSE
5 GTEx Cells EBV-transformed lymphocytes PRDX2 0.26 -0.01 enet 41 0.06 6.9e-03 4.5 6.2 6.2e-10 -0.35 0.03 0.36 FALSE
6 GTEx Cells EBV-transformed lymphocytes CTD-2659N19.10 0.25 -0.01 enet 50 0.02 6.1e-02 6.0 6.2 4.4e-10 -0.38 0.02 0.38 FALSE
7 GTEx Cells Transformed fibroblasts MAN2B1 0.15 0.10 enet 17 0.08 2.7e-06 -5.5 5.2 1.6e-07 -0.04 0.99 0.00 FALSE
8 GTEx Cells Transformed fibroblasts PRDX2 0.12 0.11 enet 18 0.12 3.0e-09 -5.1 5.7 1.2e-08 0.12 0.97 0.00 FALSE
9 GTEx Cells Transformed fibroblasts CTD-2659N19.10 0.09 0.01 lasso 7 0.01 8.1e-02 -5.1 5.4 5.8e-08 0.00 0.47 0.02 FALSE
10 GTEx Colon Transverse WDR83 0.18 0.00 enet 32 0.03 1.5e-02 -5.5 6.1 1.2e-09 -0.43 0.03 0.25 FALSE
11 GTEx Spleen MAN2B1 0.33 -0.01 enet 25 0.06 1.6e-02 -3.5 6.6 4.6e-11 -0.64 0.02 0.42 TRUE
12 GTEx Testis MAN2B1 0.18 0.07 enet 21 0.11 1.9e-05 -4.3 5.2 2.0e-07 0.00 0.90 0.01 FALSE
13 GTEx Thyroid MAN2B1 0.09 0.01 lasso 6 0.01 6.0e-02 4.0 5.2 1.7e-07 -0.08 0.10 0.10 FALSE
14 NTR Blood IER2 0.03 0.00 bslmm 334 0.01 2.0e-03 -3.8 6.4 1.5e-10 -0.15 0.22 0.03 TRUE
15 ROSMAP Brain Pre-frontal Cortex ZNF443 0.05 0.03 lasso 3 0.03 2.8e-04 -5.1 -5.2 1.5e-07 0.00 0.07 0.88 FALSE
16 YFS Blood MAN2B1 0.13 0.07 enet 32 0.12 3.1e-38 -4.0 6.2 4.0e-10 -0.09 1.00 0.00 FALSE
17 The Cancer Genome Atlas Breast Invasive Carcinoma C19orf56 0.02 0.01 blup 23 0.01 1.0e-03 -5.1 6.3 4.0e-10 -0.11 0.01 0.86 FALSE
18 The Cancer Genome Atlas Breast Invasive Carcinoma MAN2B1 0.02 0.01 blup 27 0.01 1.7e-03 -5.5 5.8 7.0e-09 -0.01 0.01 0.97 FALSE
19 The Cancer Genome Atlas Breast Invasive Carcinoma ZNF709 0.01 0.00 enet 6 0.01 9.1e-03 4.0 5.5 3.1e-08 -0.01 0.01 0.48 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MAN2B1 0.02 0.01 blup 26 0.02 3.1e-03 -5.1 6.3 3.0e-10 -0.08 0.01 0.76 FALSE
21 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WDR83 0.02 0.02 blup 19 0.02 1.6e-03 -4.3 5.4 7.7e-08 -0.03 0.01 0.84 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MAN2B1 0.03 0.01 blup 22 0.03 5.8e-04 -5.1 5.9 4.4e-09 -0.03 0.01 0.91 FALSE
23 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TNPO2 0.07 0.05 blup 11 0.07 9.5e-05 4.4 5.2 2.2e-07 -0.03 0.11 0.51 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma MAN2B1 0.13 0.09 enet 14 0.12 4.4e-13 -4.3 6.2 6.7e-10 -0.05 0.01 0.99 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF791 0.04 0.00 blup 29 0.02 6.3e-03 4.0 5.5 3.2e-08 -0.05 0.01 0.48 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma MAN2B1 0.03 0.04 blup 21 0.04 3.7e-05 -4.2 5.3 9.2e-08 0.01 0.02 0.98 FALSE
27 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C19orf56 0.42 0.00 lasso 5 0.00 1.1e-01 4.0 6.7 1.6e-11 -0.24 0.00 0.21 FALSE
28 The Cancer Genome Atlas Soft Tissue Sarcoma MAN2B1 0.40 0.08 blup 38 0.12 1.2e-07 -4.5 5.7 1.5e-08 -0.13 0.01 0.98 FALSE
29 The Cancer Genome Atlas Thyroid Carcinoma MAN2B1 0.03 0.01 blup 33 0.02 1.7e-03 -5.2 5.5 4.5e-08 0.00 0.02 0.90 FALSE