TWAS hub - PRAM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.1150	0.0430	2.6e-03	0.036	NA	0.073	NA	0.074	5.5e-04	NA	1.1e-06	NA	9.2e-07
2	NTR	Blood	0.0415	0.0130	3.8e-05	0.018	0.015	0.008	0.018	0.012	1.6e-06	0.00001	1.0e-03	1.1e-06	5.8e-05
3	ROSMAP	Brain Pre-frontal Cortex	0.0402	0.0198	2.4e-02	-0.001	0.003	0.006	0.006	0.002	4.1e-01	0.11000	4.5e-02	5.2e-02	1.4e-01
4	YFS	Blood	0.0460	0.0153	1.0e-04	0.022	0.010	0.023	0.025	0.024	7.3e-08	0.00026	3.7e-08	9.8e-09	2.4e-08
5	TCGA	Breast Invasive Carcinoma	0.0393	0.0175	2.4e-04	0.016	0.004	0.011	NA	0.010	2.3e-04	0.04800	2.0e-03	NA	3.1e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0415	0.0249	4.1e-03	-0.002	0.005	-0.002	NA	-0.002	7.2e-01	0.08700	5.9e-01	NA	6.4e-01
7	TCGA	Brain Lower Grade Glioma	0.0522	0.0223	3.1e-04	0.033	0.029	0.027	NA	0.033	9.8e-05	0.00027	3.8e-04	NA	1.0e-04
8	TCGA	Lung Adenocarcinoma	0.0366	0.0188	2.3e-03	0.001	0.019	0.004	NA	0.003	2.4e-01	0.00240	9.9e-02	NA	1.2e-01
9	TCGA	Lung Squamous Cell Carcinoma	0.0346	0.0171	1.6e-03	0.008	0.005	-0.002	NA	0.003	4.1e-02	0.07300	6.6e-01	NA	1.4e-01
10	TCGA	Prostate Adenocarcinoma	0.0407	0.0196	1.1e-03	0.028	0.030	0.035	NA	0.026	6.2e-04	0.00041	1.3e-04	NA	9.4e-04
11	TCGA	Stomach Adenocarcinoma	0.0490	0.0280	3.7e-03	0.015	0.013	0.003	NA	0.005	2.6e-02	0.03400	1.8e-01	NA	1.4e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
HDL Cholesterol	6.4	10.7	22.7	2.2	1.8	4.2	2.0	1.8	3.0	2.9	3.6	4.8	3.6	4.2
Mouth/teeth dental problems	6.3	9.6	17.2	-2.5	-3.8	-2.3	-3.2	-2.5	-2.7	-1.8	-3.1	-4.2	-3.4	-3.9
Basal cell carcinoma (self-reported)	5.5	6.5	11.6	-1.7	-1.7	-1.5	-2.4	-2.8	-2.5	-2.2	-3.1	-3.4	-2.9	-3.1
Mouth/teeth dental problems: Loose teeth	5.4	6.4	11.2	2.6	2.9	0.5	2.1	2.4	2.9	0.7	3.0	3.4	2.4	3.2
Trunk predicted mass	4.4	25.2	43.6	-4.2	-5.5	-5.8	-4.2	-1.9	-4.4	-3.0	-5.3	-6.6	-5.8	-6.5
Trunk fat-free mass	4.3	24.9	43.2	-4.1	-5.4	-5.7	-4.1	-1.9	-4.4	-3.0	-5.3	-6.6	-5.8	-6.5
Impedance of arm (left)	3.8	17.5	31.6	5.0	3.8	4.1	4.5	2.8	1.0	4.4	4.8	5.0	5.6	2.8
Arm fat-free mass (left)	3.8	19.2	30.7	-3.5	-4.9	-5.1	-3.9	-2.1	-3.7	-2.7	-4.5	-5.5	-5.3	-5.5
Arm predicted mass (left)	3.8	19.4	32.1	-3.3	-4.8	-5.3	-3.8	-1.9	-3.9	-2.6	-4.5	-5.6	-5.3	-5.7
Diabetes (father)	3.7	4.5	9.2	1.6	2.5	0.8	2.5	2.3	2.0	0.9	1.9	2.5	2.2	3.0
Arm fat-free mass (right)	3.5	17.7	28.4	-3.2	-4.4	-5.2	-3.9	-2.0	-3.4	-2.5	-4.2	-5.3	-5.2	-5.3
Medication: Blood pressure	3.4	6.0	10.2	-1.0	-2.5	-2.4	-2.0	-1.9	-2.4	-2.5	-2.6	-3.1	-3.2	-2.7
Arm predicted mass (right)	3.4	17.5	28.9	-3.1	-4.3	-5.3	-3.7	-1.8	-3.6	-2.3	-4.1	-5.3	-5.1	-5.4
Whole body water mass	3.4	19.4	33.4	-3.4	-4.6	-5.3	-3.7	-1.9	-3.9	-2.6	-4.6	-5.8	-5.2	-5.8
Coronary Artery Disease (CAD)	3.3	3.9	8.2	-1.2	-1.3	-1.2	-1.9	-1.9	-1.5	-2.0	-1.8	-2.9	-2.8	-2.4
Whole body fat-free mass	3.3	18.6	32.4	-3.3	-4.4	-5.2	-3.6	-1.8	-3.8	-2.5	-4.5	-5.6	-5.1	-5.7
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	10.2	1.0	1.9	3.1	2.1	1.4	1.7	2.7	2.2	2.8	3.2	2.4
Impedance of arm (right)	2.9	13.7	25.4	4.9	3.3	3.8	4.4	2.5	0.4	3.4	3.8	4.2	5.0	2.3
Pulse rate	2.9	5.0	10.6	2.5	1.1	1.2	1.1	2.2	2.3	1.2	2.8	3.2	2.4	2.9
Cardiovascular Disease	2.8	9.4	18.3	-3.6	-3.1	-2.8	-3.3	-2.4	-1.5	-1.9	-2.6	-4.0	-4.3	-3.0
Medication: Metformin	2.8	3.9	6.2	-1.7	-2.4	-2.3	-2.4	-1.2	-1.3	-1.3	-1.6	-2.4	-2.5	-2.1
Sitting height	2.8	20.1	40.2	-2.1	-5.1	-5.4	-3.2	-2.4	-4.9	-2.3	-4.1	-5.8	-5.1	-6.3
Time employed in main current job	2.7	3.1	5.4	0.3	-1.6	-0.9	-1.6	-2.2	-2.3	-2.0	-2.2	-1.8	-1.7	-1.8
Handedness (chirality/laterality): Left-handed	2.6	3.2	10.3	3.2	1.5	1.1	1.8	1.2	-1.6	1.9	1.5	1.8	2.2	-0.5
Basal metabolic rate	2.6	14.5	28.3	-2.6	-3.9	-4.5	-3.1	-1.5	-3.7	-2.0	-3.8	-4.9	-4.5	-5.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	7.8	-1.9	-2.3	-1.3	-2.8	-1.4	0.4	-2.0	-1.4	-1.8	-2.6	-0.3
Medication: Co-codamol	2.4	2.8	4.6	-1.1	-1.7	-1.0	-2.0	-1.5	-0.8	-2.0	-2.0	-2.1	-1.9	-1.8
Illnesses of siblings	2.4	3.3	5.8	-0.0	1.1	1.6	1.3	1.5	1.9	2.4	1.9	2.3	2.2	2.3
Mouth/teeth dental problems: Dentures	2.4	4.1	8.6	1.4	2.2	2.9	1.3	0.5	1.6	1.6	2.2	2.8	2.0	2.4
Vascular/heart problems diagnosed by doctor	2.3	6.2	15.5	3.0	2.4	2.9	2.6	2.2	0.7	1.4	1.6	2.9	3.9	2.1
Impedance of whole body	2.3	11.5	21.1	4.5	2.8	3.4	3.7	2.1	0.1	3.8	3.7	4.0	4.6	1.9
Hand grip strength (left)	2.2	5.8	14.4	-1.0	-1.9	-1.6	-1.5	-1.5	-3.3	-1.1	-3.3	-3.0	-2.6	-3.8
Father’s age at death	2.2	3.0	5.1	2.2	2.1	1.7	2.2	1.3	0.5	0.1	0.8	2.3	2.0	2.0
Medication: Aspirin	2.2	2.9	5.4	-2.1	-1.6	-1.6	-1.5	-0.6	-0.6	-1.5	-2.0	-2.3	-2.2	-1.8
Fractured/broken bones in last 5 years	2.2	2.9	6.6	-2.3	-1.8	-0.1	-2.6	-2.5	-0.8	0.1	-0.8	-1.7	-2.3	-1.1
Heart attack/myocardial infarction (self-reported)	2.2	2.8	5.4	-1.0	-1.5	-1.6	-2.0	-2.1	-0.8	-1.6	-1.4	-1.9	-2.3	-1.6
Triglycerides	2.1	3.4	9.4	-0.3	0.4	-1.6	-0.3	-1.0	-2.5	-1.7	-2.0	-2.7	-1.8	-3.1
Hypothyroidism (self reported)	2.1	4.9	18.8	-2.5	1.0	1.3	0.4	1.4	4.3	1.6	1.5	2.1	1.2	3.7
Hand grip strength (right)	2.1	5.7	14.1	-1.2	-2.3	-1.2	-1.5	-1.2	-3.1	-0.7	-3.0	-3.2	-2.6	-3.8
Medication: Simvastatin	2.1	3.1	7.0	-1.4	0.4	-2.6	-1.4	-1.0	-0.0	-2.5	-2.3	-1.9	-2.3	-0.9
Standing height	2.1	20.5	61.2	-1.6	-5.0	-5.3	-2.1	-0.7	-6.3	-0.5	-4.0	-5.7	-3.8	-7.8
Medication: Amlodipine	2.1	2.9	6.8	-2.0	-1.5	-1.3	-1.1	-0.9	-0.9	-1.6	-2.0	-2.2	-2.6	-1.7
Commuting to job workplace: Car/motor vehicle	2.1	2.5	8.0	-0.9	-1.0	-0.9	-2.8	-0.8	-0.8	-1.9	-1.7	-2.0	-1.3	-1.7
Cholesterol lowering medication	2.1	3.2	5.6	-2.2	-0.9	-1.2	-1.8	-1.8	-1.0	-0.8	-2.0	-2.4	-2.3	-2.1
High blood pressure	2.0	5.7	13.5	-3.1	-2.4	-2.4	-2.4	-2.2	-0.7	-1.5	-1.7	-2.9	-3.7	-1.9
Medication: Aspirin	2.0	2.6	5.0	-2.0	-1.6	-1.6	-1.4	-0.3	-0.5	-1.6	-1.8	-2.2	-1.9	-1.6
Vitamin and mineral supplements	1.9	2.5	6.3	1.6	1.8	0.9	1.4	1.0	-0.0	2.5	1.9	2.1	1.9	0.4
Medication: Ramipril	1.9	2.5	6.0	-0.7	-0.9	-1.1	-1.4	-2.4	-0.8	-2.3	-1.8	-1.6	-2.3	-0.3
Medication: Atorvastatin	1.9	2.4	6.2	-1.2	-0.6	-1.2	-2.5	-2.1	-0.9	-0.1	-0.8	-1.8	-1.6	-2.2
High blood pressure (mother)	1.8	2.6	6.8	-1.2	-1.1	-2.6	-0.6	-1.0	-0.8	-1.7	-1.7	-2.1	-2.2	-1.2
Diabetes (self-reported)	1.8	2.8	4.9	-1.3	-2.2	-1.7	-1.7	-0.3	-1.0	-1.5	-1.6	-2.2	-2.1	-1.6
Breastfed as a baby	1.8	2.2	7.1	2.7	1.4	2.3	1.4	1.2	-0.6	0.2	1.1	1.4	1.7	0.7
Supplements: Vitamin C	1.8	2.1	4.6	-1.2	-1.2	-1.2	-1.2	0.0	-0.5	-2.1	-2.0	-2.0	-1.9	-1.1
Medication for cholesterol	1.8	2.7	4.5	2.1	0.9	1.4	1.8	1.8	0.7	1.2	1.7	2.1	2.1	1.4
Supplements: Zinc	1.7	1.8	3.2	-0.2	-0.8	-0.5	-1.4	-1.2	-1.7	-1.5	-1.4	-1.8	-1.6	-1.6
Heart attack	1.7	2.1	4.1	-0.6	-1.3	-1.6	-1.8	-1.7	-0.7	-1.6	-1.0	-1.6	-2.0	-1.4
Heel T-Score	1.6	12.7	30.4	5.5	5.5	2.3	4.1	-0.2	-0.7	3.2	2.8	4.3	4.3	1.4
Waist Hip Ratio (WHR)	1.6	7.0	19.9	-2.8	-1.0	-4.5	-2.0	-2.0	-1.5	-1.6	-2.6	-3.2	-3.6	-2.5
Leg fat-free mass (left)	1.6	8.2	16.4	-1.9	-2.6	-3.7	-2.3	-1.1	-2.6	-1.5	-2.8	-3.8	-3.4	-4.0
Maternal smoking around birth	1.6	2.4	7.3	-1.1	-0.2	0.1	0.5	2.4	2.7	0.8	1.8	1.4	0.3	2.3
Serious illness, injury or assault to yourself	1.6	1.9	5.9	-1.4	-1.4	-1.4	-2.4	-1.4	-0.8	-0.2	-0.7	-1.5	-1.4	-1.5
Illnesses of mother	1.6	1.9	10.7	0.6	1.3	3.3	0.1	0.0	0.0	1.7	0.3	1.2	2.0	0.7
Forced vital capacity (FVC), Best measure	1.6	5.9	12.8	-1.0	-2.3	-3.6	-1.7	-1.2	-2.7	-1.2	-2.5	-3.0	-2.8	-3.1
Comparative height size at age 10	1.6	8.7	34.4	0.0	-2.2	-2.6	-0.7	-0.0	-5.2	0.7	-2.3	-3.6	-1.9	-5.9
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	13.7	-3.7	-0.2	0.1	-0.3	0.3	1.2	-0.8	-1.6	-1.3	-0.9	0.5
Hypertension (Self-reported)	1.6	4.4	10.9	-2.8	-1.9	-2.2	-2.3	-1.9	-0.5	-1.2	-1.3	-2.6	-3.3	-1.6
Leg fat-free mass (right)	1.6	8.7	16.9	-2.1	-2.6	-3.8	-2.3	-1.4	-2.7	-1.5	-3.0	-3.8	-3.7	-4.1
Leg predicted mass (right)	1.6	8.5	16.6	-2.0	-2.6	-3.7	-2.2	-1.5	-2.7	-1.4	-2.9	-3.8	-3.6	-4.1
Supplements: Calcium	1.6	1.8	7.6	-0.3	-1.0	0.6	-2.1	-1.3	0.7	-2.8	-1.0	-1.1	-1.3	-0.0
Alcohol drinker status: Previous	1.6	1.9	5.8	-1.5	-0.2	-1.8	-1.4	0.6	2.4	0.2	1.1	0.9	0.3	2.2
Fasting Glucose	1.5	1.8	6.2	1.1	-0.2	0.0	-0.7	-2.5	-1.6	-0.9	-1.1	-1.2	-1.7	-1.8
Height	1.5	28.4	85.4	-0.7	-6.4	-6.5	-1.7	-0.3	-7.8	-0.5	-4.6	-6.3	-4.4	-9.2
Type 2 Diabetes (T2D) (2018)	1.5	2.7	5.3	-1.2	-2.3	-1.8	-1.5	-0.3	-2.0	-0.6	-1.3	-1.9	-1.8	-2.2
Lung FEV1/FVC ratio	1.5	7.8	18.3	3.5	3.0	4.3	2.9	1.2	0.6	1.7	2.2	3.3	3.5	2.2
Leg predicted mass (left)	1.5	8.2	15.8	-1.9	-2.7	-3.7	-2.4	-1.2	-2.5	-1.5	-2.8	-3.8	-3.5	-4.0
Had other major operations	1.5	1.9	4.5	2.1	1.3	-0.2	1.1	1.1	0.1	1.4	2.0	1.6	1.8	0.3
Forced vital capacity (FVC)	1.5	5.9	11.6	-1.1	-2.7	-3.1	-1.4	-0.8	-3.0	-0.8	-2.5	-3.0	-2.9	-3.4
Blood clot in the leg (DVT)	1.5	2.0	4.2	-0.7	-0.8	-1.9	-2.1	-1.8	-0.6	-1.4	-1.3	-1.5	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.6	-1.4	-1.9	-2.2	-0.6	-0.3	-1.6	-1.0	-2.2	-2.6	-1.8	-2.1
Risk taking	1.5	2.2	5.7	-1.1	-2.0	-2.4	-1.2	-0.3	-1.2	-0.2	-1.2	-1.6	-1.5	-2.0
Severe depression (siblings)	1.4	1.6	8.5	-2.9	-1.2	-0.4	-1.2	0.2	2.1	-0.1	-0.1	-0.5	-0.9	0.9
Fluid intelligence score	1.4	2.9	5.7	2.3	1.4	1.5	2.3	0.3	-0.8	2.4	1.3	1.9	2.1	0.5
Birth weight of first child	1.4	2.6	3.9	1.7	1.6	1.5	1.8	1.5	0.7	1.6	1.9	1.9	2.0	1.2
Pulse rate, automated reading	1.4	4.6	9.1	3.0	1.3	1.0	1.6	2.4	1.7	0.5	2.5	2.9	2.4	2.8
Knee pain experienced in last month	1.4	2.2	5.3	2.1	0.4	1.6	1.4	1.2	-0.3	1.3	1.6	1.8	2.3	0.7
Qualifications: CSEs or equivalent	1.3	1.7	3.4	-1.0	-1.5	-0.5	-1.0	-1.3	-0.4	-1.7	-1.5	-1.8	-1.9	-0.9
Medication: Lansoprazole	1.3	1.5	4.0	-0.7	-1.4	-1.6	-0.4	-0.4	-2.0	0.5	-0.6	-1.5	-0.9	-2.0
Glaucoma (self-reported)	1.3	1.5	4.1	1.7	1.5	0.1	2.0	-0.2	-0.8	1.7	0.7	1.5	1.0	0.2
Medication: Ibuprofen	1.3	1.5	4.0	1.3	1.4	1.3	1.5	2.0	0.5	0.1	1.1	1.1	1.0	1.3
Diabetes diagnosed by doctor	1.3	2.1	3.8	-1.9	-1.9	-1.7	-1.2	0.0	-0.5	-1.1	-1.5	-1.8	-1.8	-1.1
Number of self-reported non-cancer illnesses	1.3	2.3	7.2	-2.7	-0.9	-2.3	-1.2	-0.8	1.2	-0.8	-0.7	-1.2	-2.5	-0.1
Commuting to job workplace: Cycle	1.3	1.6	3.3	1.2	1.2	1.2	1.2	0.9	0.7	1.8	1.5	1.7	1.3	0.7
HbA1C	1.2	1.3	2.8	0.8	0.9	0.6	1.5	1.7	0.5	1.1	1.1	1.2	1.5	0.9
Blood Eosinophil Count	1.2	9.6	25.6	-0.3	-3.0	-2.1	-2.2	-1.9	-4.8	-1.6	-3.4	-3.8	-2.5	-5.1
Neuroticism	1.2	2.8	10.2	-1.4	0.8	0.5	0.9	2.1	3.2	1.3	0.6	1.6	1.4	2.4
Impedance of leg (left)	1.2	5.7	10.8	3.3	1.3	2.5	2.6	1.5	-0.6	2.9	2.5	3.0	3.2	1.2
Medication: Cholesterol lowering	1.2	1.8	6.3	-0.4	0.2	-2.5	-1.1	-0.2	0.5	-2.4	-0.9	-1.3	-1.9	-0.6
Tense / ‘highly strung’	1.2	2.1	6.2	-0.3	0.6	0.3	1.4	2.5	1.8	1.4	1.5	1.2	1.7	1.4
Pulse wave reflection index	1.2	1.5	9.6	0.7	3.1	-0.2	1.3	0.0	-0.5	1.6	0.3	0.4	1.1	-0.7
Pulse wave peak to peak time	1.2	1.5	5.4	-1.3	-2.3	0.1	-1.2	-0.3	-0.2	-1.4	-1.0	-1.4	-1.5	-0.6
Emphysema/chronic bronchitis	1.2	1.4	2.5	0.3	0.6	0.4	-0.2	1.4	1.4	1.3	1.6	1.4	1.4	1.6
Angina (self-reported)	1.2	1.6	3.6	-0.1	-1.2	-1.7	-1.1	-0.5	-1.4	-0.9	-0.9	-1.4	-1.5	-1.9
Medication: Seretide 50 evohaler	1.2	1.4	4.9	0.3	-2.2	0.5	-1.4	-1.0	-1.3	-0.7	-0.8	-1.1	-0.9	-1.4
Family relationship satisfaction	1.2	1.5	4.5	-2.1	-0.7	-1.4	-1.3	-0.3	0.5	-1.1	-0.8	-1.6	-1.6	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.5	-0.9	-0.5	1.2	0.1	1.5	1.9	0.1	0.9	0.7	0.9	2.1
Osteoporosis (self-reported)	1.2	1.5	6.2	-1.0	0.5	1.5	-0.7	0.0	2.5	1.1	1.0	1.2	0.4	1.6
Medication: Gliclazide	1.2	1.3	5.9	2.4	0.6	0.7	0.6	0.3	-0.3	1.5	1.6	1.3	0.9	0.0
Depression (Nagel 2018)	1.1	1.7	4.2	-1.0	-1.3	-0.9	-2.0	-1.2	1.1	-2.0	-0.8	-1.1	-1.6	0.4
Intelligence (Savage-Jansen 2018)	1.1	3.3	11.4	1.9	0.4	3.4	1.7	-0.2	-1.2	2.9	1.4	1.6	2.0	0.3
Verbal and Numeric Reasoning (VNR)	1.1	2.6	6.5	2.1	0.5	2.6	2.1	0.2	-1.2	2.3	0.7	1.5	1.7	0.1
Lupus	1.1	1.7	5.3	-0.6	0.4	0.0	0.6	1.9	2.3	1.0	1.5	1.1	1.0	1.7
Weight	1.1	5.5	17.0	-0.6	-2.1	-2.4	-1.7	-0.8	-3.2	-0.4	-1.9	-2.8	-2.6	-4.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	7.5	0.0	0.9	0.4	-0.5	0.9	2.4	-0.3	1.1	1.5	0.7	2.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.0	1.5	1.1	0.4	1.5	2.0	0.6	0.1	1.3	1.1	0.8	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	8.2	0.4	-1.6	-1.8	-1.0	-1.3	-2.9	-1.2	-2.1	-2.2	-1.9	-2.5
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.5	0.8	0.7	-0.2	2.0	2.1	0.5	0.2	0.7	1.1	1.4	1.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	6.2	-1.5	0.1	-0.9	-0.4	0.3	2.5	-0.5	0.4	0.8	-0.4	2.0
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.8	-0.3	-0.4	-1.4	-1.9	-1.6	-0.3	-1.6	-1.0	-1.2	-1.0	-1.0
Crohns Disease (2017)	1.0	2.1	3.9	1.0	1.8	0.4	-0.2	0.7	1.6	1.1	1.8	2.0	1.8	1.9
Blood White Count	1.0	7.1	17.5	-2.9	-4.1	-1.6	-2.9	-1.5	-0.3	-2.8	-1.9	-3.0	-4.2	-1.4
Impedance of leg (right)	1.0	4.9	10.1	3.0	1.2	2.4	2.4	2.0	-0.3	2.4	2.3	2.5	3.2	1.0
Trunk fat percentage	1.0	4.2	12.2	3.5	1.8	1.2	1.6	1.3	-0.7	2.6	2.7	2.4	2.1	0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.7	1.6	0.9	1.6	0.6	-0.3	-1.2	1.6	0.9	0.9	0.8	-0.5
Alcohol usually taken with meals	1.0	1.6	5.9	2.4	0.4	1.8	-0.3	-1.5	-2.0	0.5	0.2	0.6	0.6	-1.1
Hearing difficulty/problems with background noise	1.0	1.7	3.2	-1.4	-1.8	-0.3	-1.1	-0.9	-0.9	-1.1	-1.6	-1.6	-1.4	-1.4
Hair/balding pattern: Pattern 2	1.0	1.2	2.7	0.1	0.6	1.6	1.1	1.2	1.2	0.8	1.5	1.1	1.0	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.1	1.1	0.9	0.9	1.3	0.7	1.2	-0.6	0.7	1.1	0.9	1.8
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	7.9	-2.8	0.0	0.2	-0.1	0.5	2.8	0.2	-0.0	0.5	-0.1	2.2
Body fat percentage	1.0	4.1	10.3	3.2	1.8	1.5	1.6	1.3	-0.3	2.5	2.7	2.5	2.0	0.5
Number of children fathered	1.0	1.1	2.5	-1.0	-1.6	-1.1	-0.5	-1.6	-0.7	-0.3	-1.2	-1.1	-0.9	-0.5
Heart disease (mother)	1.0	1.3	2.3	1.1	-0.9	-1.1	-1.0	-1.5	-1.1	-1.4	-0.1	-1.1	-1.5	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.7	-1.3	0.6	-0.9	0.1	1.4	1.9	-0.6	-0.1	0.4	-0.1	1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	6.0	0.5	1.2	-0.2	0.7	0.8	2.4	-0.6	1.3	1.4	0.6	2.2
Wears glasses or contact lenses	1.0	1.2	3.4	1.8	1.1	0.9	1.6	0.4	-0.7	0.9	1.0	1.1	1.2	0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	2.3	1.3	1.5	1.5	0.2	1.1	0.7	0.3	1.2	1.3	1.0	1.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.4	-0.9	-1.1	-1.4	-1.6	0.4	1.5	-0.4	1.2	-0.1	-0.5	0.5
Chronic bronchitis/emphysema (father)	0.9	1.0	3.3	-1.3	-0.0	-0.9	-1.0	0.1	1.3	-1.8	-1.0	-0.8	-0.2	1.0
Waist circumference	0.9	3.1	7.2	-0.6	-1.3	-2.0	-1.6	-0.8	-2.0	-1.0	-1.5	-2.1	-2.5	-2.7
Peak expiratory flow (PEF)	0.9	2.0	4.5	1.5	0.9	0.4	2.1	1.8	-1.7	1.9	0.4	0.5	1.6	-1.2
Birth weight	0.9	2.0	9.4	3.1	1.5	1.4	0.9	0.4	-2.1	-0.8	-0.4	-0.2	0.7	-1.3
Overall health rating	0.9	2.0	8.9	-1.8	0.3	-0.8	-1.1	-0.1	3.0	-0.7	0.2	0.5	-1.1	2.5
Leg pain on walking	0.9	1.1	5.0	0.5	0.3	-0.0	0.1	-0.9	1.7	-0.3	1.0	1.4	-0.1	2.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.2	4.5	0.1	0.7	0.8	2.0	0.4	-0.7	2.1	0.1	0.8	1.2	-0.3
Average weekly red wine intake	0.9	1.4	4.1	2.0	1.4	1.1	-0.7	-0.7	-0.3	1.0	1.6	1.3	1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	5.2	-0.3	-0.2	-0.1	-1.0	-1.4	-2.3	-1.0	-1.9	-1.7	-1.4	-1.8
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.4	-0.7	-1.6	-0.1	-1.0	-0.6	-1.3	-0.6	-1.3	-1.3	-1.0	-1.3
Unable to work because of sickness or disability	0.9	1.2	3.1	0.3	-0.1	1.3	-0.9	-0.6	1.6	0.4	1.4	1.4	0.7	1.8
Worry (Nagel 2018)	0.8	1.8	7.2	-0.8	0.9	-0.0	0.6	1.8	2.7	0.6	1.3	1.0	1.2	1.7
Prostate Cancer	0.8	1.1	3.5	1.7	0.2	0.2	1.0	-1.4	-1.9	1.0	0.2	0.6	-0.1	-0.9
Angina	0.8	1.1	3.2	0.4	-1.0	-1.4	-0.8	-0.3	-1.4	-0.7	-0.6	-1.1	-1.1	-1.8
Fed-up feelings	0.8	1.4	5.8	0.2	0.5	0.7	0.6	0.9	2.3	-0.3	0.6	1.5	0.4	2.4
Medication: Levothyroxine sodium	0.8	1.3	4.6	-2.1	-0.1	-0.3	0.3	1.3	2.1	-1.0	-0.4	-0.0	-0.2	1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.3	-2.1	0.6	-1.5	-1.3	-0.7	1.6	-0.1	-0.3	-0.1	-0.4	0.5
Worrier / anxious feelings	0.8	1.5	4.4	-1.2	1.2	-0.7	1.1	1.9	2.1	0.4	0.4	0.8	0.6	1.7
Hair/balding pattern: Pattern 3	0.8	1.2	4.5	-2.1	-0.6	-1.4	-0.0	-0.2	-0.3	-0.8	-1.8	-1.1	-0.8	-0.2
Hair/balding pattern: Pattern 4	0.8	2.0	8.3	2.9	1.5	1.2	0.8	0.3	-1.1	1.3	1.3	1.5	1.4	0.4
Medication: Paracetamol	0.8	1.4	5.5	-1.3	0.3	0.4	-1.1	1.1	2.3	0.1	1.2	0.6	-0.1	1.8
Worry too long after embarrassment	0.8	1.4	3.6	0.8	1.4	-0.1	0.2	1.0	0.7	1.9	1.3	1.6	1.6	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.6	0.3	-0.0	0.2	0.1	2.1	1.1	0.8	1.0	1.2	1.4	0.9
Medication for pain relief, constipation, heartburn	0.8	1.4	4.7	0.9	0.2	0.7	0.3	-1.3	-1.9	2.2	-0.1	0.2	0.7	-1.7
Alcohol intake frequency.	0.8	1.8	5.5	1.1	1.2	-0.2	1.1	1.3	1.6	-0.4	1.0	1.8	1.5	2.4
Number of full sisters	0.8	0.9	2.3	0.4	0.5	1.1	1.5	1.2	0.5	1.4	1.2	1.0	0.6	0.3
Chest pain or discomfort	0.8	1.1	3.8	-1.0	-0.2	0.2	-2.0	-1.7	1.1	-0.4	-0.4	0.1	-1.0	1.2
High cholesterol (Self-reported)	0.8	1.4	6.5	-0.5	0.6	-2.5	0.1	-0.7	-0.3	-1.2	-1.2	-1.1	-1.5	-0.9
Neuroticism (Nagel 2018)	0.7	1.6	8.3	-0.7	0.2	0.2	0.3	1.6	2.9	0.4	1.2	0.9	0.8	1.7
Irritable Bowel Disease (IBD)	0.7	1.6	3.7	0.3	1.2	0.4	0.8	1.7	1.3	1.1	1.4	1.6	1.9	1.4
Crohns Disease (2012)	0.7	1.1	2.9	1.7	0.7	0.4	0.0	0.0	-0.4	1.5	1.5	1.4	1.4	0.5
Number of treatments/medications taken	0.7	1.2	3.1	-0.8	-0.9	-0.7	-1.4	-1.3	-0.5	-1.3	-1.0	-1.3	-1.8	-0.5
Financial difficulties in last 2 years	0.7	0.9	3.0	0.6	-0.1	-0.4	-1.0	0.6	1.7	-0.2	1.7	0.9	0.5	1.3
Neuroticism score	0.7	1.4	4.6	-0.4	0.8	0.1	0.3	1.0	2.1	1.0	0.6	1.5	1.1	2.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	7.9	0.2	-1.4	-1.2	-0.4	-0.5	-2.8	-0.3	-1.7	-1.8	-1.5	-2.4
Pulse wave Arterial Stiffness index	0.7	0.8	2.9	1.1	1.7	-0.5	0.9	0.2	-0.3	1.2	0.6	0.8	1.1	-0.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	3.1	-0.1	-1.3	-1.8	-1.2	-1.1	-0.0	-1.1	-0.5	-0.3	-0.8	-0.0
Headache pain in last month	0.7	1.1	3.2	-0.1	-0.4	1.3	-0.7	0.5	1.8	0.5	1.2	1.3	0.1	1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.4	-0.8	-0.6	0.5	-1.2	-1.8	-0.8	-0.5	-0.6	-0.9	-1.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.5	-1.9	-0.8	-0.4	-1.4	0.3	0.9	0.8	0.3	-0.5	-0.1	-0.4
Migraine (self-reported)	0.7	0.8	2.0	0.4	0.9	0.1	1.4	1.2	0.7	0.8	0.6	1.2	1.0	0.9
Illnesses of siblings: Diabetes	0.7	0.9	2.5	1.1	-0.4	-0.4	-0.6	-0.2	-1.6	-1.2	-0.6	-0.9	-0.9	-1.5
Long-standing illness, disability or infirmity	0.7	1.0	3.9	-0.9	-0.5	0.1	-2.0	-0.5	1.7	-0.8	0.2	0.0	-0.7	1.3
Back pain experienced in last month	0.7	1.0	2.9	1.0	0.3	-0.9	-0.1	1.0	0.9	0.7	1.7	1.1	1.2	0.9
Mineral and other dietary supplements	0.7	0.9	5.3	0.1	0.6	-0.6	1.0	-0.2	-0.0	2.3	1.1	1.4	0.3	0.5
Illnesses of father: None of the above (group 1)	0.7	0.8	3.9	0.8	0.8	1.4	0.4	-2.0	-0.8	0.8	-0.1	0.5	0.0	-0.1
Miserableness	0.7	1.1	2.7	1.0	0.3	-0.4	0.8	1.5	0.5	1.6	1.2	1.4	1.2	0.7
Medication: Paracetamol	0.7	1.1	3.8	-1.2	0.3	1.3	-1.1	1.0	1.9	0.1	0.7	0.5	0.1	1.6
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	1.0	1.2	0.0	0.8	-0.2	0.1	0.8	1.3	1.4	0.9	0.8
LDL Cholesterol	0.6	1.0	2.8	1.0	1.7	-0.1	1.4	1.3	-0.3	1.3	0.6	0.6	0.9	-0.3
Neuroticism (2016)	0.6	0.9	2.0	-1.2	-0.2	-0.4	-0.8	-1.1	1.0	-1.4	-1.3	-0.7	-1.3	0.5
Primary Biliary Cirrhosis	0.6	0.9	3.0	1.4	0.7	-0.5	-0.3	0.3	-1.7	0.7	0.6	-0.2	0.3	-1.7
Blood Platelet Count	0.6	7.4	21.3	2.8	2.1	4.6	2.8	1.4	0.5	2.6	2.6	3.1	3.1	2.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.7	-0.5	-0.2	0.7	-0.3	0.4	1.6	-0.1	0.7	0.8	0.7	1.6
Diabetes (mother)	0.6	0.8	3.0	-1.2	0.2	-1.2	-0.7	1.1	1.7	-0.1	0.8	-0.0	0.2	0.8
Relative age voice broke	0.6	0.9	3.0	0.1	1.7	0.8	1.3	-0.1	-0.4	1.7	0.3	0.8	0.8	-0.0
Taking other prescription medications	0.6	1.0	3.1	-0.9	-1.3	-0.3	-1.3	-1.1	0.0	-1.0	-0.5	-1.0	-1.8	-0.3
Medication: Atenolol	0.6	0.8	1.8	0.4	-0.3	1.2	1.1	-0.6	-1.4	1.0	-0.1	-0.1	-0.8	-1.2
Number of incorrect matches in round	0.6	1.0	3.8	-1.0	0.5	-0.3	-0.1	-0.3	-1.1	-1.0	-1.9	-1.4	-0.6	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.3	0.4	1.5	-0.8	1.8	-0.5	0.7	1.8	1.1	1.4	1.1	0.7
Hip circumference	0.6	2.5	8.6	0.7	-1.8	-0.3	-1.0	-0.6	-2.8	-0.4	-1.1	-1.6	-1.5	-2.9
Depression (self-reported)	0.6	0.7	1.9	0.6	0.2	0.3	-0.4	0.9	1.1	-0.3	0.7	1.1	0.9	1.4
Loud music exposure frequency	0.6	0.7	2.2	-1.1	-0.2	-1.1	-1.5	-1.2	-0.2	-0.4	-0.8	-0.7	-0.4	-0.3
High blood pressure (siblings)	0.6	0.9	4.0	0.2	-0.0	-1.2	-0.4	-0.5	-0.3	-2.0	-1.0	-1.2	-0.9	-0.8
Health satisfaction	0.6	0.8	3.1	-1.8	-0.1	-0.6	-0.7	-0.5	0.7	-0.7	-1.0	-1.0	-1.1	0.2
Suffer from ‘nerves’	0.6	0.9	4.1	-0.2	0.3	0.8	-0.5	0.9	2.0	-0.3	0.8	0.7	0.7	1.5
Arm fat percentage (left)	0.6	2.2	5.4	2.3	1.6	1.3	1.0	1.0	0.1	1.7	2.1	1.9	1.3	0.5
Qualifications: nursing, teaching	0.6	1.0	2.1	1.0	1.3	1.1	1.0	-0.4	-1.0	1.3	0.3	0.9	1.5	-0.1
Eye problems/disorders: Cataract	0.6	0.7	1.7	0.4	1.1	1.3	1.0	1.2	0.2	1.1	0.7	0.7	0.7	0.1
Smoking status: Current	0.6	1.0	3.4	-0.6	0.7	-0.0	-0.2	1.7	1.9	0.4	0.8	0.7	0.5	1.6
Hearing aid user	0.6	0.7	2.4	0.5	-0.6	0.3	-0.7	-1.6	-0.7	-1.3	-0.8	-0.7	-0.5	-0.4
Medication: Blood pressure	0.6	1.1	2.2	-1.2	-0.5	-1.1	-1.2	-1.4	-0.7	-0.4	-0.8	-1.2	-1.5	-1.0
Medication: Lisinopril	0.6	0.8	3.2	-1.5	-0.3	-1.8	-1.2	-0.1	0.6	-0.2	-0.4	-0.8	-0.7	-0.1
Illnesses of father: High blood pressure	0.6	0.8	3.8	1.9	-0.8	0.5	-0.9	-1.0	-1.4	-0.4	0.2	0.2	-0.1	-0.2
Reaction Time	0.5	1.0	3.2	-0.6	0.4	1.0	-0.8	-1.8	0.5	-1.5	-1.3	-0.4	-0.9	0.7
Age at First Birth	0.5	0.7	2.9	0.4	1.0	-0.2	1.7	0.6	0.5	-0.8	-0.1	0.8	0.5	1.1
Mean Putamen Volume	0.5	0.5	1.8	-0.8	-0.2	-0.6	0.3	0.7	1.3	0.0	0.5	0.5	0.5	1.3
Rheumatoid Arthritis	0.5	0.7	2.4	1.6	-0.0	-0.0	-0.6	0.6	0.5	-0.7	0.9	0.8	0.3	1.4
Systolic Blood Pressure	0.5	2.3	4.7	-1.0	-2.1	-2.0	-1.0	-0.9	-1.2	-1.1	-1.0	-1.8	-2.2	-1.3
Chronotype (morning person)	0.5	1.2	5.2	1.9	-0.4	-0.7	0.9	0.2	-2.3	-0.3	-0.1	-0.2	0.4	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.6	0.4	-0.2	-0.2	-1.1	-0.9	1.2	-1.6	0.1	0.1	-0.6	1.1
Relative age of first facial hair	0.5	1.0	3.5	-0.7	0.9	1.9	0.6	0.9	1.4	0.7	0.5	0.8	0.5	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.4	0.1	-0.5	-1.2	-1.0	-0.5	-0.8	-0.7	-0.2	-0.9	-0.9	-1.2
Current tobacco smoking	0.5	0.8	3.4	-0.8	0.5	0.2	-0.4	1.3	1.9	0.5	0.6	0.6	0.2	1.3
Multivitamins +/- minerals	0.5	0.7	2.0	-1.2	-0.6	-0.1	-0.5	-0.5	0.9	-1.4	-0.7	-0.9	-0.8	0.5
Happiness	0.5	0.7	2.4	0.7	-0.0	0.3	0.2	-0.1	1.3	-0.0	1.1	1.0	0.5	1.6
Lung cancer (father)	0.5	0.5	1.1	0.3	0.1	-0.0	0.9	1.0	0.7	0.4	0.5	1.0	0.9	1.0
Shortness of breath walking on level ground	0.5	0.5	1.3	-1.2	-0.5	0.7	-1.0	-1.0	0.6	1.1	0.4	0.2	-0.4	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.7	-0.1	-1.3	-0.4	-0.2	-0.2	-0.8	-0.9	-0.7	-1.1	-0.5	-1.1
Medication: Omeprazole	0.5	0.6	1.8	0.2	-0.8	-0.8	0.5	-1.0	-0.4	-1.1	-0.5	-0.5	-1.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	1.1	-0.3	0.8	0.3	-1.4	-1.4	0.0	-0.3	0.1	-0.3	-0.6
Illnesses of father: Heart disease	0.5	0.7	3.5	-0.2	-0.2	-1.9	-0.4	1.0	-0.3	0.3	0.1	-0.8	0.1	-1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.8	-1.7	0.3	-0.2	0.7	0.5	-0.2	0.8	-1.3	-0.5	-0.3	-0.6
Eye problems/disorders: Glaucoma	0.5	0.6	2.7	0.6	0.7	-0.6	0.1	-1.6	-0.6	1.2	-0.1	0.7	0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.1	0.6	-0.1	1.4	0.0	1.0	-0.5	-1.0	-0.3	-0.9	0.2	-0.9
Leg fat percentage (left)	0.5	1.8	4.5	2.1	1.0	1.1	1.0	1.0	-0.2	1.7	1.9	1.9	1.1	0.3
Ever depressed for a whole week	0.5	0.6	2.7	-0.9	-1.3	0.2	-1.6	-0.8	0.1	-0.1	-0.3	-0.4	-0.6	0.1
Pain experienced in last month	0.5	0.8	3.1	-1.8	0.2	0.3	0.6	-0.0	-0.3	-0.7	-1.5	-1.4	-0.8	-0.6
Pack years of smoking	0.5	0.7	1.8	-0.9	-1.4	-1.0	-1.3	0.6	1.2	0.1	0.6	0.2	-0.5	0.3
Bipolar Disorder (2018)	0.4	0.7	2.9	-0.2	-0.4	-0.7	-0.8	-1.7	-1.3	0.4	-0.5	-0.4	-0.5	-0.8
Depressed Affect (Nagel 2018)	0.4	0.8	3.8	-0.3	-0.2	0.5	0.3	0.9	2.0	0.6	0.8	0.8	0.6	1.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.7	-0.7	0.7	-1.3	0.6	0.7	1.0	-0.2	0.1	0.3	0.2	0.4
Schizophrenia (2014)	0.4	1.0	4.0	1.2	1.0	-0.0	-0.1	-0.3	-1.1	2.0	1.4	0.7	0.6	-0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.1	0.1	-0.9	0.5	-0.1	-0.8	-0.6	-0.9	-0.8	-1.0	-0.9
Average weekly spirits intake	0.4	0.5	2.8	-1.7	-0.1	0.9	-0.7	0.3	1.0	-0.1	0.0	-0.8	-0.1	-0.0
Hearing difficulty/problems: Yes	0.4	0.6	3.4	-1.2	-1.8	-0.3	-0.6	-0.2	0.0	-0.3	-0.6	-0.7	-0.5	-0.5
Age when periods started (menarche)	0.4	0.9	2.7	-1.0	-1.6	0.7	-1.5	1.0	1.0	0.9	0.9	0.1	0.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.7	-1.2	-0.7	-1.6	-0.1	-0.3	0.4	0.3	0.0	-0.3	-0.3	-0.1
Stomach or abdominal pain in last month	0.4	0.6	1.8	-0.3	-0.2	-0.2	-1.3	0.1	1.4	0.1	1.1	0.5	-0.5	0.8
Supplements: Glucosamine	0.4	0.5	1.2	0.8	-0.9	0.8	-0.8	-1.1	0.1	-1.1	-0.0	-0.1	0.0	0.3
Qualifications: None of the above	0.4	0.8	5.1	0.6	-0.1	-0.5	-0.1	0.4	0.8	-2.3	-0.1	-0.1	-0.9	1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.7	-0.2	0.6	1.4	-0.2	0.8	0.8	0.9	0.5	0.8	1.7	0.8
Prospective memory result	0.4	0.5	2.2	-0.4	-0.4	-0.6	-1.5	-0.9	0.7	-0.7	-0.1	-0.1	-0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.0	-0.7	-1.4	-1.3	-0.8	1.0	0.6	-0.3	0.1	-0.2	0.1	-0.0
Leg fat percentage (right)	0.4	1.6	3.5	1.9	0.9	1.1	0.9	1.5	-0.1	1.4	1.7	1.6	1.1	0.2
Exposure to tobacco smoke outside home	0.4	0.5	2.3	-1.5	-0.3	-0.5	-0.7	-0.6	0.9	0.3	-0.0	-0.6	-0.8	0.2
Wheeze or whistling in the chest in last year	0.4	0.6	2.6	-0.2	0.1	0.1	-1.6	-1.0	1.1	-0.5	0.8	0.2	-0.9	0.6
Mean time to correctly identify matches	0.4	0.7	2.6	0.6	0.4	0.9	-0.5	-1.6	-0.5	-1.3	-1.1	-0.4	-0.7	-0.1
Had major operations	0.4	0.4	1.7	-0.5	0.1	1.3	0.3	1.2	0.9	0.1	0.2	0.0	0.3	0.3
Loneliness, isolation	0.4	0.5	2.1	-1.4	-0.9	-0.7	-0.3	-0.4	0.1	0.1	-0.5	-0.8	-1.1	-0.5
Osteoarthritis (self-reported)	0.4	0.5	2.0	1.4	-0.4	0.6	0.5	0.7	-0.9	-0.6	-0.4	0.0	0.5	-0.4
Mother’s age at death	0.4	0.4	2.4	0.9	-0.1	1.5	0.2	-0.8	-0.8	0.1	-0.2	0.1	0.4	-0.4
Alcohol drinker status: Never	0.4	0.5	2.8	-0.1	0.1	-1.7	0.3	0.5	1.1	-0.5	0.2	0.3	0.3	0.8
Number of operations (self-reported)	0.4	0.6	1.4	0.9	-0.4	-0.0	0.9	1.0	-1.2	0.7	0.5	-0.1	0.3	-1.0
Bipolar Disorder or Schizophrenia	0.3	0.7	3.7	1.1	0.4	-0.5	-0.2	-0.9	-1.9	0.9	0.2	-0.0	0.2	-1.1
Schizophrenia (2018)	0.3	0.7	2.3	1.5	0.9	-0.1	0.5	0.2	-1.4	0.9	0.6	0.4	0.6	-0.7
Ulcerative Colitis (UC)	0.3	0.6	2.6	-1.2	-0.0	0.1	0.8	1.6	0.6	0.4	-0.1	0.1	0.9	0.4
Ovarian Cancer	0.3	0.4	0.8	0.1	0.0	0.8	0.9	0.5	-0.9	-0.1	-0.5	-0.7	0.1	-0.8
Blood Red Count	0.3	3.3	9.7	1.9	3.1	0.9	2.2	0.1	0.5	1.0	1.2	2.3	2.1	2.2
BMI	0.3	1.8	4.0	-0.2	-1.0	0.8	-1.5	-1.7	-0.9	-1.9	-1.5	-1.2	-2.0	-1.0
Smoking Status	0.3	0.8	3.4	-1.0	0.8	0.6	0.1	0.5	1.8	0.9	0.4	0.7	0.2	1.3
Allergy or Eczema	0.3	0.8	2.7	-1.1	0.9	-0.8	0.8	1.4	0.0	1.6	0.2	0.4	0.7	-0.3
Lung FVC	0.3	1.7	4.2	-0.2	-1.1	-1.0	-0.7	-1.2	-1.0	-1.9	-1.9	-1.4	-2.1	-0.8
Pack years adult smoking proportion	0.3	0.5	1.6	-0.4	-1.3	-1.2	-1.0	0.4	0.6	0.1	0.5	0.2	-0.7	0.1
Average weekly fortified wine intake	0.3	0.3	1.2	0.9	0.0	1.1	-0.4	-1.1	-0.3	-0.1	-0.0	0.5	0.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.6	0.6	1.6	-0.8	1.3	-1.1	-0.2	1.0	0.1	0.7	0.8	-0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-1.3	0.7	-0.6	0.9	0.9	0.5	1.1	0.1	0.5	0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.8	0.3	-0.3	1.4	-0.1	-0.4	0.7	0.1	0.8	0.3	0.4	0.5
Trunk fat mass	0.3	1.3	4.3	2.1	0.1	-0.4	0.4	0.6	-1.8	1.6	1.0	0.4	0.3	-1.7
Nervous feelings	0.3	0.6	1.2	0.7	0.7	1.1	-0.4	-0.2	1.1	-0.2	0.6	0.7	0.8	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.2	0.0	-1.5	0.1	-0.4	-0.2	1.0	-0.8	0.3	0.3	-0.9	0.9
Pain all over the body in last month	0.3	0.3	0.8	0.3	0.0	0.3	-0.6	-0.7	0.0	-0.9	-0.7	-0.2	-0.8	0.1
Arm fat percentage (right)	0.3	1.2	4.1	2.0	1.0	1.0	0.7	0.7	-0.3	1.1	1.5	1.3	0.8	0.1
Number of live births	0.3	0.4	2.1	-1.0	-0.4	-0.6	-0.1	0.3	0.1	1.4	0.5	0.2	0.7	0.0
Noisy workplace	0.3	0.4	1.1	-0.1	0.2	-0.2	0.0	0.9	0.7	1.0	0.9	0.6	0.4	0.5
Length of working week for main job	0.3	0.3	0.9	0.4	0.9	0.9	-0.7	0.3	-0.6	0.1	0.5	0.1	0.0	-0.3
Comparative body size at age 10	0.3	0.9	3.9	-0.9	-0.1	-1.4	-1.6	-2.0	0.5	0.1	0.1	0.0	-0.9	0.4
Number of full brothers	0.3	0.3	2.0	-0.2	-0.8	0.0	-0.3	0.1	0.2	-1.4	-0.3	-0.4	-0.4	0.6
Qualifications: College or University degree	0.3	0.8	3.8	1.9	-0.2	1.1	-0.3	-1.1	-0.9	0.0	0.2	0.4	1.1	-0.6
Neck or shoulder pain in last month	0.3	0.5	1.8	0.6	0.3	0.4	-0.7	-0.7	0.3	0.9	0.6	1.4	0.6	0.5
Age at last live birth	0.3	0.5	2.1	-0.4	0.5	-0.3	0.6	0.5	-0.9	1.4	-0.3	0.0	0.9	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.5	0.1	0.3	-1.6	0.2	-0.3	-0.1	-0.9	-0.4	-0.1	-0.7	0.2
Smoking status: Previous	0.3	0.4	1.6	-0.7	-0.3	0.2	-0.1	-1.2	-0.3	0.5	-0.7	-0.5	-0.7	-0.9
Friendships satisfaction	0.3	0.4	1.4	-1.1	0.4	-0.2	-0.1	-0.6	1.2	0.6	0.2	0.2	-0.4	0.6
Financial situation satisfaction	0.3	0.4	1.1	-0.9	-1.1	-0.0	0.0	0.1	-0.5	0.1	-0.4	-0.9	-0.8	-0.7
Average weekly beer plus cider intake	0.3	0.4	1.3	0.3	0.0	-0.1	0.7	1.2	1.1	-0.7	0.2	0.0	-0.3	0.4
Irritability	0.3	0.5	1.7	-0.9	-1.3	0.6	-1.1	-0.0	0.8	-0.3	-0.6	-0.0	-0.3	0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.2	-0.0	-0.5	-0.5	-0.5	0.5	-1.0	0.7	0.2	-0.4	-0.1	-1.1
Diastolic blood pressure, automated reading	0.3	0.8	3.7	-0.6	-0.6	-1.9	-1.0	-0.1	0.6	-1.0	-0.1	-0.7	-1.2	0.2
Myopia	0.3	0.4	1.4	-0.3	-0.3	-1.2	-0.7	-0.1	-0.5	-0.3	-0.5	-0.8	-0.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.1	1.1	-0.0	0.2	1.4	-0.4	-0.7	-0.5	-0.3	0.3	-0.4	-0.0
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.1	-0.2	-0.4	-0.1	-0.8	-0.6	-0.7	-0.3	-0.5	-0.7	0.1
Alzheimer’s Disease (including proxy)	0.2	0.2	0.8	-0.0	0.8	-0.9	0.7	0.1	0.2	-0.4	0.0	0.2	0.1	0.4
Major Depression (MDD)	0.2	0.2	0.8	0.0	-0.9	0.0	-0.5	-0.6	-0.5	-0.9	-0.4	-0.3	-0.0	-0.1
Ulcerative Colitis	0.2	0.2	0.7	-0.3	-0.3	0.0	0.7	0.8	-0.6	0.5	-0.3	-0.4	0.5	-0.5
Respiratory disease	0.2	0.4	1.4	-0.5	-0.9	0.2	-1.2	0.1	0.8	0.3	1.0	0.3	0.1	0.4
Tanning	0.2	2.7	9.7	-3.1	-1.1	-1.4	-1.6	0.5	0.1	-1.0	-1.9	-2.3	-1.5	-1.3
Sensitivity / hurt feelings	0.2	0.4	1.6	-0.2	0.1	-0.9	-0.3	0.3	1.3	-0.3	0.2	0.6	-0.4	0.9
Ever had hysterectomy (womb removed)	0.2	0.2	1.0	0.3	-0.3	0.3	-0.2	-0.2	-1.0	0.4	-0.1	-0.2	0.3	-0.7
Systolic blood pressure, automated reading	0.2	0.6	3.4	-0.5	-0.8	-1.8	-0.1	-0.2	-0.4	-0.5	-0.2	-0.8	-0.7	-0.4
Medication for hormone replacement therapy	0.2	0.3	0.8	-0.1	0.6	-0.3	-0.0	-0.6	-0.7	-0.6	-0.9	-0.4	-0.1	-0.5
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.8	-0.2	-0.6	0.5	0.3	-0.6	0.0	0.0	-0.1	-0.8	-0.9
Past tobacco smoking	0.2	0.3	1.6	1.3	0.6	0.1	0.6	0.2	-0.7	-0.3	0.4	0.4	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.0	-0.7	0.5	-0.6	-0.2	0.9	-0.2	0.3	0.4	0.2	0.8
Falls in the last year	0.2	0.3	0.9	-0.8	-0.9	-0.2	-0.9	-0.3	0.1	0.1	-0.1	-0.3	-0.4	0.1
Arm fat mass (right)	0.2	0.9	3.0	0.5	-0.8	-1.0	-0.7	-0.0	-1.4	-0.1	-0.3	-0.8	-1.1	-1.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	1.2	-0.8	0.5	0.4	0.3	0.2	-0.1	1.1	-0.4	-0.1	0.1	-0.3
Age at first live birth	0.2	0.4	2.0	0.1	0.5	0.6	1.4	-0.2	-0.6	0.0	-0.9	0.0	0.6	-0.1
Medication: Allopurinol	0.2	0.3	1.4	1.2	-0.1	0.5	-0.0	0.1	-0.7	0.5	0.4	0.4	0.4	-0.2
Whole body fat mass	0.2	0.9	2.7	1.6	0.1	-0.5	0.2	0.5	-1.5	1.2	0.8	0.3	0.0	-1.4
Mood swings	0.2	0.3	0.6	0.8	-0.1	-0.7	0.6	0.6	0.2	0.6	0.6	0.7	0.1	0.5
Commuting to job workplace: Walk	0.2	0.2	0.9	0.5	-0.1	0.3	0.9	-0.8	-0.3	0.2	0.1	0.1	0.1	0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.9	1.0	-0.9	0.1	-0.4	-0.3	-0.4	-0.2	-0.0	0.5	0.6	0.4
Guilty feelings	0.2	0.3	1.0	-0.3	-0.6	-0.1	-0.3	0.1	0.7	-1.0	-1.0	-0.1	-0.6	0.8
Ever taken oral contraceptive pill	0.2	0.3	1.1	-0.7	0.5	-0.3	-0.1	0.1	0.4	-1.0	-0.8	-0.1	0.4	0.4
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.4	-0.7	0.3	0.8	-0.8	-0.7	-0.1	-0.1	-0.1	-0.5	0.0
Medication: Bendroflumethiazide	0.2	0.2	0.8	-0.7	-0.6	-0.2	-0.9	0.1	-0.1	0.2	-0.1	-0.5	-0.2	-0.7
Ever smoked	0.2	0.3	1.4	-1.2	-0.6	-0.3	-0.7	0.3	1.0	0.1	-0.4	-0.4	-0.1	-0.0
Age started oral contraceptive pill	0.2	0.2	0.9	-0.7	-0.2	-0.9	-0.2	0.7	0.2	-0.3	-0.2	-0.5	0.1	-0.4
Heart disease (siblings)	0.2	0.3	0.9	-0.3	-0.5	-0.4	0.9	-0.1	0.1	-0.5	-0.5	-0.1	-1.0	0.4
Breast Cancer	0.1	0.2	0.5	0.2	0.5	0.5	0.0	0.3	0.6	0.3	0.5	0.6	0.6	0.7
Hair Pigment	0.1	2.0	4.6	-0.6	-1.7	0.0	-1.5	-2.1	-0.8	-1.8	-1.4	-1.3	-2.0	0.2
Body mass index (BMI)	0.1	0.3	1.1	-0.2	-0.1	-0.2	-1.0	-0.5	-0.4	-0.2	-0.3	-0.4	-1.0	-0.8
Had menopause	0.1	0.2	0.6	-0.8	0.3	-0.0	-0.3	0.1	0.6	-0.7	-0.1	-0.3	-0.0	0.3
Allergy	0.1	0.3	1.5	1.0	0.2	1.2	0.0	0.3	0.4	-0.6	0.2	0.2	0.3	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.6	-0.2	0.6	-0.5	0.8	0.4	0.5	-0.4	-0.0	-0.0	-0.4	0.4
Asthma	0.1	0.2	0.6	0.8	-0.2	0.4	-0.1	-0.6	-0.4	0.2	0.8	0.2	0.1	-0.2
Exposure to tobacco smoke at home	0.1	0.2	0.9	-0.2	-1.0	0.4	-0.1	0.1	0.4	-0.3	0.0	-0.4	-0.3	-0.3
Gout (self-reported)	0.1	0.1	0.4	0.6	-0.7	0.4	-0.2	0.1	-0.3	-0.1	-0.0	-0.1	-0.3	-0.4
Leg fat mass (right)	0.1	0.4	1.6	0.9	-0.1	-0.3	-0.1	0.7	-1.1	0.7	0.4	0.0	-0.3	-1.3
Ever had bowel cancer screening	0.1	0.1	0.5	0.1	0.5	0.3	0.2	0.4	-0.6	0.1	-0.0	-0.3	-0.3	-0.7
Breast cancer (self-reported)	0.1	0.1	0.4	-0.7	0.1	0.3	0.6	-0.4	-0.1	0.3	-0.5	0.2	0.1	0.4
Asthma (self-reported)	0.1	0.2	0.9	0.9	0.1	0.5	0.2	-0.4	-0.1	0.2	0.9	0.5	0.2	0.2
Arm fat mass (left)	0.1	0.6	2.2	0.4	-0.7	-0.9	-0.7	0.1	-1.1	0.2	0.0	-0.6	-0.9	-1.5
Leg fat mass (left)	0.1	0.4	1.5	0.9	-0.2	-0.3	-0.2	0.3	-1.1	0.7	0.3	0.0	-0.5	-1.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

PRAM1

Models

Trait associations