Best TWAS P=1.81e-08 · Best GWAS P=5.5e-08 conditioned to 0.00466
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | MSH6 | 0.11 | 0.03 | enet | 18 | 0.06 | 2.4e-04 | 4.7 | 5.4 | 7.7e-08 | -0.43 | 0.06 | 0.59 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | MSH6 | 0.07 | 0.05 | enet | 23 | 0.05 | 5.1e-07 | 4.7 | 5.6 | 1.8e-08 | -0.54 | 0.01 | 0.98 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MSH6 | 0.07 | 0.02 | blup | 26 | 0.06 | 6.2e-07 | 3.1 | 5.5 | 4.0e-08 | -0.36 | 0.08 | 0.27 | FALSE |