[Hub]/) : Traits : Heel T-Score : ← →

chr2:53,384,500-56,342,798

Best TWAS P=4.79e-261 · Best GWAS P=0 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACYP2	0.06	0.02	blup	561	0.03	4.8e-05	1.89	-11.8	6.7e-32	0.00	0.73	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	C2orf73	0.06	0.01	lasso	5	0.03	2.0e-04	7.48	-13.2	1.4e-39	-0.10	0.46	0.05	FALSE
3	CommonMind	Brain Pre-frontal Cortex	EML6	0.06	0.00	blup	675	0.03	9.2e-05	-23.81	-24.5	3.2e-132	0.00	0.58	0.01	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PSME4	0.07	0.03	lasso	4	0.04	1.7e-05	-10.06	-9.4	3.5e-21	0.00	0.85	0.01	TRUE
5	GTEx	Artery Aorta	SPTBN1	0.17	0.09	enet	15	0.10	2.7e-06	18.60	9.5	2.2e-21	-0.02	0.99	0.00	FALSE
6	GTEx	Artery Aorta	HMGB1P31	0.17	0.05	enet	31	0.07	7.4e-05	1.53	5.3	9.3e-08	-0.02	0.76	0.01	FALSE
7	GTEx	Artery Aorta	AC093110.3	0.13	0.14	lasso	8	0.10	4.5e-06	19.81	20.1	5.7e-90	0.03	0.99	0.00	FALSE
8	GTEx	Artery Aorta	RP11-477N3.1	0.22	0.06	enet	36	0.06	3.3e-04	-7.49	5.4	5.6e-08	0.13	0.26	0.06	FALSE
9	GTEx	Artery Tibial	SPTBN1	0.21	0.14	lasso	5	0.15	1.1e-11	19.81	13.0	1.8e-38	0.03	1.00	0.00	FALSE
10	GTEx	Artery Tibial	EML6	0.24	0.16	lasso	7	0.22	2.9e-17	11.20	10.7	1.3e-26	0.06	1.00	0.00	FALSE
11	GTEx	Artery Tibial	AC093110.3	0.11	0.14	lasso	3	0.14	2.5e-11	19.81	20.0	2.6e-89	0.03	1.00	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	HMGB1P31	0.28	0.12	lasso	3	0.08	5.5e-03	-5.48	-5.2	1.7e-07	-0.12	0.16	0.05	TRUE
13	GTEx	Brain Frontal Cortex BA9	SPTBN1	0.25	0.00	enet	23	0.07	6.5e-03	13.00	12.5	8.4e-36	-0.02	0.09	0.05	FALSE
14	GTEx	Brain Putamen basal ganglia	AC093110.3	0.32	-0.01	enet	25	0.10	2.4e-03	-3.74	9.9	4.4e-23	0.07	0.08	0.07	FALSE
15	GTEx	Breast Mammary Tissue	AC093110.3	0.16	0.00	lasso	3	0.00	4.3e-01	14.03	10.3	7.2e-25	-0.05	0.12	0.04	TRUE
16	GTEx	Breast Mammary Tissue (Female)	AC093110.3	0.11	0.00	lasso	3	0.00	2.2e-01	15.87	17.8	5.9e-71	0.08	0.06	0.05	FALSE
17	GTEx	Cells Transformed fibroblasts	AC093110.3	0.21	0.13	lasso	6	0.11	1.3e-08	-23.68	23.7	2.2e-124	-0.03	1.00	0.00	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	RP11-477N3.1	0.23	0.13	lasso	4	0.10	2.6e-04	-7.49	7.1	1.2e-12	0.04	0.19	0.05	FALSE
19	GTEx	Esophagus Muscularis	CCDC88A	0.16	0.01	lasso	7	0.00	1.8e-01	-5.09	-6.3	2.5e-10	0.00	0.39	0.04	TRUE
20	GTEx	Esophagus Muscularis	ACYP2	0.24	0.25	enet	21	0.25	2.5e-15	1.53	5.9	4.4e-09	0.18	1.00	0.00	FALSE
21	GTEx	Esophagus Muscularis	EML6	0.35	0.35	lasso	7	0.36	6.9e-23	11.20	10.5	7.2e-26	0.09	1.00	0.00	FALSE
22	GTEx	Heart Left Ventricle	RTN4	0.19	0.05	enet	18	0.08	3.7e-05	-3.14	-6.0	1.7e-09	-0.06	0.34	0.03	FALSE
23	GTEx	Heart Left Ventricle	RP11-477N3.1	0.32	0.10	enet	26	0.24	8.1e-13	2.75	7.8	9.2e-15	0.30	0.87	0.01	TRUE
24	GTEx	Liver	HMGB1P31	0.18	0.03	enet	9	0.05	1.9e-02	8.13	9.2	3.3e-20	0.08	0.08	0.05	FALSE
25	GTEx	Lung	PRORSD1P	0.12	0.10	lasso	6	0.08	7.2e-07	-3.25	-6.1	1.2e-09	-0.12	0.95	0.00	TRUE
26	GTEx	Muscle Skeletal	SPTBN1	0.10	0.09	enet	14	0.10	1.3e-09	8.16	5.9	3.5e-09	-0.14	1.00	0.00	FALSE
27	GTEx	Muscle Skeletal	AC093110.3	0.09	0.04	enet	14	0.07	9.1e-08	1.11	6.2	7.4e-10	-0.13	0.99	0.00	FALSE
28	GTEx	Nerve Tibial	MTIF2	0.11	0.01	enet	7	0.04	8.1e-04	18.45	12.7	9.9e-37	-0.08	0.09	0.06	FALSE
29	GTEx	Ovary	CLHC1	0.49	0.26	lasso	6	0.17	4.9e-05	-4.10	-7.1	1.7e-12	0.04	0.07	0.63	FALSE
30	GTEx	Ovary	ACYP2	0.27	0.16	lasso	4	0.08	6.2e-03	0.83	5.7	1.1e-08	0.13	0.29	0.05	FALSE
31	GTEx	Pancreas	EML6	0.34	0.11	lasso	10	0.13	3.9e-06	19.28	-16.7	5.7e-63	0.00	0.94	0.00	TRUE
32	GTEx	Pancreas	AC093110.3	0.27	0.02	enet	24	0.03	1.4e-02	-3.28	-11.3	1.5e-29	-0.24	0.05	0.39	TRUE
33	GTEx	Prostate	HMGB1P31	0.53	0.19	enet	25	0.27	1.5e-07	2.00	-12.5	1.3e-35	-0.40	0.49	0.17	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	HMGB1P31	0.18	0.01	enet	16	0.09	1.2e-05	-5.57	-11.0	3.8e-28	-0.32	0.19	0.13	FALSE
35	GTEx	Skin Sun Exposed Lower leg	PSME4	0.10	0.04	lasso	5	0.04	2.1e-04	-10.03	-10.5	9.8e-26	-0.04	0.34	0.03	TRUE
36	GTEx	Skin Sun Exposed Lower leg	RP11-477N3.1	0.11	0.04	lasso	4	0.06	6.7e-06	-4.53	-5.6	2.0e-08	-0.01	0.38	0.02	TRUE
37	GTEx	Spleen	CLHC1	0.32	0.22	lasso	3	0.29	4.0e-08	-4.10	-5.4	7.5e-08	0.05	0.73	0.02	FALSE
38	GTEx	Testis	MTIF2	0.13	0.01	enet	23	0.01	8.5e-02	-1.64	5.3	8.7e-08	-0.13	0.11	0.24	FALSE
39	GTEx	Thyroid	SPTBN1	0.14	0.01	lasso	6	0.03	1.3e-03	-7.10	-6.7	2.6e-11	-0.07	0.56	0.02	FALSE
40	GTEx	Thyroid	EML6	0.26	0.20	enet	46	0.24	5.8e-18	18.22	-15.9	4.5e-57	0.09	1.00	0.00	FALSE
41	GTEx	Whole Blood	SPTBN1	0.13	0.04	lasso	6	0.08	5.7e-08	-15.96	-23.4	5.1e-121	-0.13	0.99	0.00	FALSE
42	METSIM	Adipose	EML6	0.05	0.06	lasso	3	0.05	1.5e-08	13.06	13.8	3.3e-43	0.00	1.00	0.00	FALSE
43	METSIM	Adipose	RTN4	0.07	0.05	blup	584	0.04	1.0e-06	1.69	-8.0	1.1e-15	0.03	0.99	0.00	FALSE
44	NTR	Blood	ACYP2	0.02	0.02	enet	15	0.02	8.9e-07	3.51	15.2	7.6e-52	0.32	1.00	0.00	FALSE
45	NTR	Blood	SPTBN1	0.06	0.04	bslmm	640	0.04	3.2e-14	-26.24	-32.6	2.2e-233	-0.14	1.00	0.00	TRUE
46	ROSMAP	Brain Pre-frontal Cortex	SPTBN1	0.10	0.03	enet	22	0.06	1.1e-08	7.98	-12.9	8.4e-38	-0.15	0.86	0.00	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	GPR75	0.17	0.13	lasso	4	0.16	7.0e-20	-2.64	-5.8	6.8e-09	0.00	1.00	0.00	TRUE
48	ROSMAP	Brain Pre-frontal Cortex	CLHC1	0.11	0.04	lasso	8	0.07	9.9e-10	-5.71	-5.6	2.8e-08	0.09	1.00	0.00	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	TSPYL6	0.07	0.03	lasso	2	0.05	6.5e-07	-12.06	13.7	1.0e-42	0.12	0.96	0.00	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	AC092839.1	0.10	0.07	enet	17	0.09	4.3e-12	-22.20	-20.4	6.5e-93	0.01	1.00	0.00	FALSE
51	YFS	Blood	PSME4	0.04	0.02	enet	20	0.04	1.1e-11	6.14	8.5	1.5e-17	-0.03	1.00	0.00	TRUE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PSME4	0.05	0.02	blup	65	0.02	8.9e-03	5.10	5.2	2.2e-07	-0.02	0.11	0.03	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	C2orf73	0.12	0.09	lasso	6	0.12	1.4e-22	7.48	-12.9	3.9e-38	0.00	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPL23AP32	0.02	0.02	blup	50	0.02	1.1e-05	-25.79	-26.7	1.5e-156	-0.03	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SPTBN1	0.05	0.03	blup	163	0.03	2.9e-04	1.36	-7.2	7.4e-13	-0.31	0.23	0.06	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACYP2	0.04	0.02	enet	8	0.02	6.6e-03	0.19	5.9	3.3e-09	0.11	0.16	0.04	TRUE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C2orf73	0.09	0.01	lasso	3	0.06	2.0e-07	7.47	-13.5	1.1e-41	0.00	0.46	0.02	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML6	0.14	0.13	lasso	4	0.13	1.0e-14	-21.95	-20.2	8.5e-91	-0.01	1.00	0.00	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPL23AP32	0.09	0.10	lasso	4	0.10	7.3e-11	14.02	-20.2	4.2e-91	-0.01	0.62	0.38	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C2orf73	0.16	0.05	enet	12	0.06	2.4e-04	-12.98	-18.1	5.1e-73	-0.24	0.48	0.10	TRUE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	C2orf73	0.19	0.08	lasso	6	0.16	2.8e-18	-12.74	-14.9	1.9e-50	-0.09	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPL23AP32	0.05	0.03	blup	50	0.04	4.3e-05	-23.78	-26.9	8.1e-159	-0.03	0.05	0.95	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPTBN1	0.10	0.04	lasso	3	0.05	2.1e-06	-18.90	-17.8	1.2e-70	-0.23	0.84	0.00	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSPYL6	0.09	0.05	lasso	5	0.06	2.8e-07	-12.06	11.4	4.0e-30	0.08	0.55	0.42	TRUE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf73	0.05	0.02	lasso	7	0.04	3.9e-05	7.48	-12.6	1.7e-36	-0.01	0.33	0.02	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	RTN4	0.07	0.08	blup	100	0.08	1.9e-09	-2.94	5.9	2.9e-09	0.00	1.00	0.00	TRUE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RTN4	0.04	0.01	enet	3	0.01	1.5e-02	-2.94	6.6	4.2e-11	0.00	0.09	0.07	TRUE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C2orf73	0.12	0.09	lasso	4	0.07	1.2e-05	-12.74	-11.1	1.1e-28	-0.13	0.62	0.02	TRUE
69	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RTN4	0.11	0.05	lasso	6	0.06	9.5e-05	5.35	6.0	1.6e-09	0.02	0.65	0.02	FALSE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C2orf73	0.30	0.23	blup	70	0.21	9.8e-09	7.48	-11.5	2.2e-30	0.05	0.99	0.00	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPTBN1	0.15	0.07	lasso	3	0.05	5.2e-03	6.34	-9.7	2.8e-22	-0.12	0.07	0.12	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	C2orf73	0.29	0.13	lasso	4	0.17	1.4e-17	7.47	-13.3	3.3e-40	0.00	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL23AP32	0.06	0.02	enet	6	0.03	1.7e-04	-22.09	-18.8	5.4e-79	0.02	0.04	0.84	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPTBN1	0.06	0.04	blup	163	0.05	3.1e-06	16.74	11.1	1.3e-28	-0.11	0.97	0.00	TRUE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPL23AP32	0.04	0.03	blup	50	0.02	1.2e-02	-23.63	-26.1	6.0e-150	-0.02	0.01	0.85	TRUE
76	The Cancer Genome Atlas	Stomach Adenocarcinoma	RTN4	0.14	0.09	enet	14	0.11	2.9e-08	-2.94	5.5	4.9e-08	0.04	0.97	0.00	TRUE
77	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C2orf73	0.15	0.00	enet	13	0.06	3.8e-03	1.36	-8.3	9.2e-17	0.11	0.05	0.08	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHAC2	0.19	0.03	blup	43	0.07	2.4e-03	-4.39	-7.1	1.1e-12	-0.03	0.00	0.75	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	C2orf73	0.45	0.26	lasso	6	0.32	1.1e-31	7.48	-12.7	6.7e-37	0.02	1.00	0.00	TRUE
80	The Cancer Genome Atlas	Thyroid Carcinoma	EML6	0.05	0.05	lasso	4	0.05	3.1e-05	15.30	-17.2	1.5e-66	0.03	0.86	0.02	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	RPL23AP32	0.06	0.04	blup	50	0.03	1.3e-03	-22.20	-25.3	6.3e-141	-0.01	0.03	0.89	FALSE
82	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SPTBN1	0.39	0.04	blup	163	0.12	3.6e-04	-30.03	-34.5	4.8e-261	-0.49	0.04	0.46	TRUE