Best TWAS P=1.4e-53 · Best GWAS P=3.65e-119 conditioned to 1.09e-47
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PKDCC | 0.19 | 0.02 | blup | 559 | 0.06 | 2.1e-07 | 23.0 | 15.4 | 1.4e-53 | 0.55 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | MTA3 | 0.35 | 0.00 | enet | 22 | 0.04 | 2.4e-02 | 1.1 | 7.3 | 2.6e-13 | 0.21 | 0.14 | 0.08 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | PKDCC | 0.57 | 0.01 | enet | 22 | 0.01 | 1.4e-01 | -1.9 | -9.0 | 2.7e-19 | -0.37 | 0.12 | 0.17 | FALSE |
| 4 | GTEx | Heart Left Ventricle | PKDCC | 0.28 | 0.08 | lasso | 4 | 0.14 | 8.7e-08 | 10.4 | -7.4 | 1.2e-13 | 0.00 | 0.96 | 0.00 | TRUE |
| 5 | GTEx | Nerve Tibial | ZFP36L2 | 0.06 | 0.00 | lasso | 8 | 0.01 | 3.5e-02 | 8.8 | -7.5 | 6.0e-14 | 0.00 | 0.06 | 0.80 | FALSE |
| 6 | GTEx | Thyroid | AC010883.5 | 0.11 | 0.09 | lasso | 2 | 0.08 | 1.5e-06 | 8.6 | 8.6 | 7.1e-18 | 0.00 | 0.62 | 0.36 | FALSE |
| 7 | YFS | Blood | MTA3 | 0.02 | 0.00 | blup | 598 | 0.01 | 1.2e-03 | -1.7 | -7.9 | 2.4e-15 | -0.23 | 0.37 | 0.03 | TRUE |
| 8 | YFS | Blood | THADA | 0.01 | 0.00 | blup | 724 | 0.00 | 1.1e-02 | -3.4 | -6.2 | 6.1e-10 | -0.05 | 0.08 | 0.02 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | PKDCC | 0.05 | 0.01 | blup | 80 | 0.04 | 2.6e-03 | -1.4 | 14.4 | 7.5e-47 | 0.77 | 0.02 | 0.53 | TRUE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZFP36L2 | 0.03 | 0.01 | blup | 38 | 0.01 | 1.1e-02 | 3.5 | -8.8 | 2.1e-18 | -0.02 | 0.02 | 0.53 | TRUE |