TWAS hub - TANC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.158	0.065	0.00520	0.084	NA	-0.005	NA	0.029	2.3e-05	NA	8.8e-01	NA	9.4e-03
2	GTEx	Brain Cerebellum	0.517	0.114	0.00170	0.230	NA	0.135	NA	0.238	2.1e-07	NA	8.6e-05	NA	1.2e-07
3	GTEx	Cells Transformed fibroblasts	0.096	0.037	0.00180	0.026	NA	0.050	NA	0.046	4.4e-03	NA	1.2e-04	NA	2.2e-04
4	GTEx	Thyroid	0.111	0.047	0.00220	0.004	NA	0.024	NA	0.017	1.6e-01	NA	5.3e-03	NA	1.8e-02
5	TCGA	Thyroid Carcinoma	0.076	0.029	0.00013	0.037	0.036	0.012	NA	0.026	1.5e-04	0.00019	2.4e-02	NA	1.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Pulse rate, automated reading	3.8	12.2	33.5	-1.4	-4.6	-2.0	-0.7	-5.8
Exposure to tobacco smoke at home	3.2	3.6	8.6	-2.5	-0.8	-2.9	-0.7	-1.5
Pulse rate	3.0	5.0	12.4	-1.3	-2.9	-1.7	-0.2	-3.5
Eye problems/disorders: Cataract	3.0	3.5	7.0	1.2	2.0	2.6	-1.7	1.4
Number of operations (self-reported)	2.9	4.3	11.4	-2.5	-0.4	-3.4	-0.4	-1.9
Alzheimer’s Disease (in mother)	2.5	2.9	7.4	0.4	2.1	1.5	0.7	2.7
Fasting Glucose	2.5	3.0	8.7	0.5	-1.4	-0.2	-2.1	-3.0
Heel T-Score	2.5	19.6	39.6	-0.5	-5.6	-1.5	4.9	-6.3
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	12.0	1.3	0.2	2.4	3.5	-0.4
Hypertension (Self-reported)	2.3	6.5	17.9	-2.3	0.3	-3.0	-4.2	0.2
Hair/balding pattern: Pattern 3	2.2	3.3	4.8	-1.2	2.0	-1.7	2.2	1.9
Lupus	2.1	3.1	6.2	-1.9	2.0	-2.5	0.8	1.0
High blood pressure	2.1	5.8	15.1	-2.1	-0.0	-3.0	-3.9	-0.3
Worry too long after embarrassment	2.1	3.6	11.6	0.9	3.4	0.2	1.5	1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.4	10.4	0.6	-2.9	0.2	1.8	-3.2
Medication: Blood pressure	2.0	3.5	12.8	-1.1	-0.3	-1.9	-3.6	0.2
Bipolar Disorder (2011)	1.9	1.9	5.5	0.9	-0.9	1.4	2.4	0.4
Townsend deprivation index at recruitment	1.9	2.7	6.0	-2.4	-1.0	-2.4	0.5	-0.4
Taking other prescription medications	1.9	3.0	9.0	-1.5	-1.3	-0.3	-3.0	-1.4
Medication: Atenolol	1.9	2.3	5.9	-2.3	-0.5	-2.4	-0.4	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.1	-0.9	-2.2	-0.5	-0.4	-2.3
Number of self-reported non-cancer illnesses	1.9	3.3	10.8	-1.3	-0.7	-1.5	-3.3	-1.0
Vascular/heart problems diagnosed by doctor	1.9	5.1	14.5	1.9	0.3	2.6	3.8	0.4
Supplements: Calcium	1.9	2.1	5.8	0.2	1.7	0.2	1.3	2.4
Ulcerative Colitis (UC)	1.8	3.5	14.8	-0.2	0.4	0.7	-3.9	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	8.6	0.8	-2.6	0.1	2.3	-2.9
Average weekly red wine intake	1.8	2.6	5.0	1.7	1.4	2.2	-1.6	1.0
Medication: Cholesterol lowering	1.7	2.6	9.9	-0.6	-0.1	-1.4	-3.1	0.8
Pulse wave Arterial Stiffness index	1.7	2.0	5.2	-0.8	-0.8	-0.9	-1.7	-2.3
Number of full sisters	1.7	2.0	4.4	-1.5	0.0	-2.1	1.3	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.8	0.4	-1.9	-0.1	0.5	-2.2
Medication: Atorvastatin	1.7	2.1	4.1	-1.1	-1.0	-1.8	-2.0	-1.0
Alzheimer’s Disease (including proxy)	1.6	2.3	4.1	0.8	1.2	2.0	1.2	2.0
Cardiovascular Disease	1.6	5.4	19.9	-1.6	0.3	-2.1	-4.5	-0.4
Relative age voice broke	1.6	2.4	5.3	-0.2	2.3	-1.3	2.0	0.9
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.4	-0.9	1.2	-1.6	1.8	1.2
Had menopause	1.6	2.0	3.5	1.9	1.8	1.6	-0.1	1.0
Worrier / anxious feelings	1.6	3.1	10.6	-0.5	3.3	-0.4	0.3	2.1
Birth weight	1.6	3.5	8.1	2.4	0.1	2.9	1.8	0.3
Medication: Bendroflumethiazide	1.6	2.4	7.5	-1.3	-0.2	-1.5	-2.7	-0.7
Arm fat-free mass (left)	1.6	8.2	34.3	0.1	-0.3	1.5	-5.9	-2.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.5	0.9	-1.6	0.3	-1.9	-1.1
Hip circumference	1.5	6.7	29.8	-0.7	-0.1	1.6	-5.5	-0.7
Lung cancer (father)	1.5	1.8	5.6	-1.4	0.2	-1.1	-2.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	6.9	-2.1	0.4	-2.6	0.2	-0.4
Had major operations	1.5	1.8	3.9	-1.0	-0.5	-1.7	-2.0	-1.0
Osteoarthritis (self-reported)	1.5	2.0	4.3	-0.9	2.1	-0.4	-2.0	0.8
Illnesses of father: None of the above (group 1)	1.5	1.8	4.5	1.0	-1.1	2.1	-0.3	-1.6
Risk taking	1.5	2.2	6.2	-0.6	-1.9	-0.9	-0.4	-2.5
Arm predicted mass (left)	1.5	7.8	32.3	0.4	-0.1	1.8	-5.7	-1.9
Nervous feelings	1.4	2.5	5.0	-1.4	0.8	-2.2	1.6	1.5
Pain all over the body in last month	1.4	1.5	2.9	-0.4	1.7	-0.3	1.4	1.5
Trunk fat-free mass	1.4	8.3	32.3	0.9	-0.1	2.3	-5.7	-1.7
Falls in the last year	1.4	1.9	4.3	-0.4	-1.7	0.6	-2.1	-1.4
Trunk predicted mass	1.4	8.1	32.0	0.8	-0.0	2.3	-5.7	-1.6
Pulse wave peak to peak time	1.4	1.7	4.8	0.8	0.6	0.7	1.4	2.2
Arm predicted mass (right)	1.4	7.3	29.6	0.4	-0.6	1.5	-5.4	-2.0
Whole body fat-free mass	1.4	8.3	34.6	0.2	-0.2	1.9	-5.9	-1.7
Osteoporosis (self-reported)	1.4	1.8	4.9	0.8	1.6	0.4	0.7	2.2
Whole body water mass	1.4	7.9	32.8	0.3	-0.2	1.8	-5.7	-1.8
Basal metabolic rate	1.4	7.7	32.9	-0.2	-0.3	1.6	-5.7	-1.7
Diastolic blood pressure, automated reading	1.4	4.4	12.4	-2.5	-0.3	-3.5	-1.2	1.3
Coronary Artery Disease (CAD)	1.3	1.6	5.3	1.3	2.3	0.6	-0.2	0.7
HbA1C	1.3	1.5	5.3	2.3	0.5	1.1	0.6	-0.6
Chronotype (morning person)	1.3	3.1	6.8	-0.5	-2.2	-1.4	-1.2	-2.6
Leg fat-free mass (left)	1.3	6.8	29.8	-0.7	-0.2	1.2	-5.5	-1.4
Leg predicted mass (left)	1.3	6.7	29.7	-0.7	-0.1	1.2	-5.5	-1.3
Weight	1.3	6.5	28.6	-0.6	-0.1	1.1	-5.3	-1.5
Arm fat-free mass (right)	1.3	6.6	26.9	0.5	-0.5	1.5	-5.2	-1.8
Eye problems/disorders: None of the above	1.3	1.5	3.2	-1.1	-0.9	-1.5	1.8	-0.0
Leg fat-free mass (right)	1.3	7.0	29.9	-0.5	-0.4	1.5	-5.5	-1.5
Leg predicted mass (right)	1.3	6.9	29.4	-0.5	-0.3	1.5	-5.4	-1.6
Average weekly champagne plus white wine intake	1.3	1.8	5.2	-0.4	-2.3	0.7	-0.8	-1.6
Prospective memory result	1.2	1.5	3.5	0.7	-1.6	0.4	0.7	-1.9
Peak expiratory flow (PEF)	1.2	2.8	7.6	1.9	1.6	2.8	0.5	0.3
Medication: Amlodipine	1.2	1.6	4.4	1.1	0.4	1.6	-2.1	-0.2
Number of full brothers	1.2	1.5	2.3	-1.5	-1.2	-1.3	0.0	-1.4
Shortness of breath walking on level ground	1.2	1.5	4.9	0.8	-0.8	0.7	-2.2	-0.9
Medication: Aspirin	1.2	1.6	3.8	-0.5	1.4	-0.6	-1.9	1.2
Medication: Aspirin	1.2	1.6	2.6	-0.8	1.2	-0.7	-1.6	1.6
Miserableness	1.2	2.0	6.5	-0.7	2.6	-1.1	0.1	1.4
Unable to work because of sickness or disability	1.2	1.6	3.7	-1.9	-0.6	-1.8	0.6	0.3
Commuting to job workplace: Cycle	1.2	1.5	4.5	2.1	0.3	1.5	0.2	0.8
Systolic blood pressure, automated reading	1.1	3.3	7.3	-1.1	1.4	-2.5	0.1	2.7
Vitamin and mineral supplements	1.1	1.5	5.6	0.5	-0.8	0.3	-2.4	-0.8
Medication: Metformin	1.1	1.6	6.2	-0.6	0.1	-1.0	-2.5	-0.7
Diabetes (mother)	1.1	1.4	4.0	-2.0	0.4	-1.6	-0.1	0.4
Multivitamins +/- minerals	1.1	1.4	6.7	-0.2	0.5	-0.4	2.6	-0.0
Medication: Levothyroxine sodium	1.1	1.8	5.5	-1.7	0.0	-2.4	-0.8	0.3
Birth weight of first child	1.1	2.0	5.8	0.8	1.1	2.4	-0.7	1.3
Heart disease (mother)	1.1	1.4	2.9	-1.7	-1.3	-1.2	0.8	-0.6
Age at last live birth	1.1	1.5	4.0	-0.3	1.2	-0.6	2.0	1.3
Medication: Blood pressure	1.1	2.0	8.8	-0.4	-0.7	-0.0	-3.0	-0.8
Age started oral contraceptive pill	1.1	1.4	1.9	1.0	1.4	1.0	-1.3	1.1
Basal cell carcinoma (self-reported)	1.1	1.4	3.6	-0.4	-1.7	0.1	-0.0	-1.9
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.1	0.5	1.4	-0.1	-1.1	1.5
Ulcerative Colitis	1.0	1.4	3.5	-0.1	1.9	-0.3	-1.9	-0.1
Waist circumference	1.0	3.7	16.4	-0.8	0.3	0.4	-4.0	-1.0
Alcohol usually taken with meals	1.0	1.7	5.0	0.6	-1.1	2.2	-1.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.2	-1.0	1.8	-0.5	-0.0	1.7
Mouth/teeth dental problems	1.0	1.5	2.7	1.0	-1.0	1.3	-1.1	-1.6
Medication: Simvastatin	1.0	1.4	3.1	-1.3	0.5	-1.2	-1.8	0.7
Number of children fathered	1.0	1.1	2.7	0.9	1.4	0.3	-1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.4	0.3	-1.4	-0.7	-0.6	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.4	-0.7	-1.9	-0.8	-1.2	-2.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.3	0.7	0.5	1.3	1.8	-0.5
Long-standing illness, disability or infirmity	1.0	1.6	6.7	-0.0	0.9	0.1	-2.6	0.6
Mineral and other dietary supplements	1.0	1.3	3.8	0.5	-1.9	-0.0	-0.8	-1.3
High cholesterol (Self-reported)	1.0	1.7	5.8	-1.3	-0.4	-0.9	-2.4	-0.3
Medication: Paracetamol	1.0	1.5	3.2	1.8	-1.4	1.4	0.5	0.4
Major Depression (MDD)	0.9	1.1	4.8	-0.0	0.2	0.2	2.2	0.9
Reaction Time	0.9	1.7	3.7	-1.0	-0.5	-1.8	-1.9	-0.5
Age at First Birth	0.9	1.3	3.8	-1.0	-1.0	-0.5	-1.9	0.5
Triglycerides	0.9	1.5	4.3	-0.5	1.2	-1.2	-2.1	0.4
Supplements: Glucosamine	0.9	1.2	3.0	0.6	1.7	1.2	-1.1	-0.3
Chronic bronchitis/emphysema (father)	0.9	1.1	2.1	-1.4	-0.6	-1.2	-1.1	0.4
Body mass index (BMI)	0.9	3.8	15.2	-0.7	1.4	1.0	-3.9	-0.0
Fluid intelligence score	0.9	1.9	5.3	-0.2	1.6	-0.2	2.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.8	-1.0	-0.7	-2.2	0.1	-0.9
Medication: Lansoprazole	0.9	1.0	1.7	-0.1	-1.3	1.1	-0.7	-1.3
Impedance of arm (left)	0.9	4.1	14.7	-1.3	-0.8	-1.8	3.8	0.4
Arm fat mass (right)	0.9	3.5	15.1	-1.1	0.9	0.7	-3.9	-0.3
Loud music exposure frequency	0.9	0.9	2.7	1.4	0.1	-0.0	1.6	0.4
Medication: Paracetamol	0.9	1.5	2.4	1.5	-1.5	1.2	1.1	-0.4
High blood pressure (siblings)	0.9	1.2	4.7	-0.2	-0.1	-2.2	-0.8	0.9
Comparative body size at age 10	0.9	2.4	6.9	2.1	0.1	2.6	0.6	0.8
Leg fat mass (right)	0.9	3.3	14.7	-0.7	1.0	0.7	-3.8	-0.1
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.0	-0.8	0.4	-1.2	1.1	1.4
Diabetes diagnosed by doctor	0.9	1.5	6.8	0.2	-0.1	-0.8	-2.6	-0.6
Commuting to job workplace: Walk	0.9	1.0	2.0	-1.4	1.2	-0.3	-0.3	1.3
Ever depressed for a whole week	0.9	1.1	3.0	-0.4	1.7	-1.4	-0.0	0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.3	0.2	-1.8	1.1	-0.4	-1.2
Alcohol drinker status: Previous	0.9	1.0	2.9	-1.7	-0.6	-0.8	1.0	0.2
Leg fat mass (left)	0.9	3.6	16.2	-0.6	0.9	0.9	-4.0	-0.2
Systolic Blood Pressure	0.8	3.8	11.4	-1.7	0.5	-3.4	-0.3	2.2
Hypothyroidism (self reported)	0.8	1.8	4.8	-1.9	-0.5	-2.2	-0.2	-0.3
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.9	0.2	-1.3	-0.5	-2.2	-0.6
Neuroticism	0.8	1.9	3.7	-1.2	1.9	-1.1	1.3	1.1
Number of treatments/medications taken	0.8	1.4	6.2	0.5	-0.7	0.2	-2.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.7	0.8	0.8	0.5	-1.6	0.8
Current tobacco smoking	0.8	1.3	2.8	0.5	-1.7	0.7	0.8	-1.6
Heart attack	0.8	1.0	2.7	0.1	-1.6	1.0	-0.4	-1.0
Medication: Ramipril	0.8	1.0	2.4	0.2	0.8	0.5	-1.6	1.4
Noisy workplace	0.8	1.0	1.5	-0.6	-0.8	-1.2	-1.2	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	0.7	-1.4	1.1	0.3	-1.0
Angina (self-reported)	0.8	1.1	2.6	-1.3	-0.0	-1.1	0.3	1.6
Medication: Ibuprofen	0.8	1.0	3.4	0.4	0.3	-1.0	1.8	0.6
Medication: Seretide 50 evohaler	0.8	1.0	2.1	1.1	1.4	1.1	-0.5	0.3
Alcohol intake frequency.	0.8	1.9	5.8	-2.4	-0.2	-1.7	0.8	0.5
Ever had bowel cancer screening	0.8	1.0	2.3	0.1	1.5	0.9	0.6	1.1
Smoking status: Current	0.8	1.3	3.5	0.3	-1.9	0.2	1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	5.6	1.2	-0.3	2.4	-0.3	1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.2	-1.1	0.1	-1.5	-1.0	-0.3
Average weekly beer plus cider intake	0.8	1.1	2.6	-1.0	-1.1	-0.6	-0.4	-1.6
Impedance of whole body	0.8	4.3	16.5	-0.8	-1.0	-1.8	4.1	0.4
Smoking Status	0.7	1.7	4.1	1.4	-0.7	2.0	0.4	-1.3
Ever had hysterectomy (womb removed)	0.7	0.7	1.6	-0.2	-1.0	-0.3	-1.2	-1.1
Angina	0.7	0.9	1.8	-1.2	-0.1	-1.2	0.1	1.3
Impedance of leg (right)	0.7	3.5	13.1	-0.3	-0.5	-1.9	3.6	0.5
Maternal smoking around birth	0.7	1.0	3.0	0.6	1.3	0.4	1.7	0.3
Serious illness, injury or assault to yourself	0.7	0.9	2.6	-0.2	1.0	-0.1	-1.6	0.9
Hayfever, allergic rhinitis or eczema	0.7	1.6	2.2	-1.5	-1.4	-1.5	-1.2	-0.1
High blood pressure (mother)	0.7	1.0	4.0	-0.6	-0.7	-2.0	0.3	0.4
Trunk fat mass	0.7	2.8	12.2	-0.9	0.6	0.5	-3.5	-0.6
Hair/balding pattern: Pattern 2	0.7	0.9	2.9	0.2	-0.4	0.1	-1.7	-1.2
Had other major operations	0.7	0.8	1.3	-1.1	0.1	-1.1	-1.1	-0.6
Diabetes (self-reported)	0.7	1.1	5.1	-0.1	0.1	-0.7	-2.3	-0.4
Neuroticism score	0.7	1.4	2.7	-0.7	1.5	-0.7	1.6	1.0
Impedance of arm (right)	0.7	3.5	10.8	-1.6	-0.6	-1.8	3.3	0.6
Standing height	0.7	6.9	16.8	0.6	-2.7	0.8	-4.1	-3.0
Breastfed as a baby	0.7	0.8	2.8	-0.7	0.5	0.5	-1.7	0.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	0.6	1.5	-0.0	0.9	1.2
Glaucoma (self-reported)	0.7	0.9	1.8	0.1	0.1	1.2	-1.4	-1.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.6	-1.8	-0.0	-1.9	-0.6	0.1
Health satisfaction	0.7	0.9	2.3	1.4	-0.1	1.5	-0.4	-0.0
Medication: Omeprazole	0.7	0.9	1.6	-1.0	-0.9	-1.3	0.7	-0.7
Whole body fat mass	0.7	3.1	13.7	-0.9	0.7	0.4	-3.7	-0.6
Supplements: Vitamin C	0.7	0.8	3.0	-0.3	0.7	-0.2	1.7	0.8
Illnesses of siblings: Diabetes	0.7	0.8	1.8	0.7	-1.4	-0.0	-0.7	-1.1
Smoking status: Previous	0.7	1.0	3.1	0.8	0.7	1.8	-0.7	0.3
Qualifications: nursing, teaching	0.7	1.0	3.0	-1.7	0.8	-1.1	-0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.9	-1.2	-0.0	-1.7	-0.8	-0.5
Medication for cholesterol	0.7	1.1	4.5	0.8	0.3	-0.0	2.1	0.0
Breast cancer (self-reported)	0.7	0.9	2.2	0.7	0.8	0.8	-1.5	0.8
Arm fat mass (left)	0.7	2.9	11.5	-1.1	1.1	0.5	-3.4	-0.3
Wears glasses or contact lenses	0.7	0.8	1.4	-0.8	1.2	-0.6	-1.0	0.9
Ever taken oral contraceptive pill	0.7	0.8	1.7	1.3	0.7	1.0	0.8	0.3
Eye problems/disorders: Glaucoma	0.7	0.8	2.1	0.2	0.2	1.1	-1.4	-0.8
Myopia	0.7	1.0	2.0	0.2	-1.4	0.4	1.1	-1.2
Intelligence (Savage-Jansen 2018)	0.6	1.9	2.4	1.1	1.5	1.5	1.3	1.5
Schizophrenia vs Biploar Disorder	0.6	0.8	1.5	1.2	0.5	0.6	1.1	-0.8
Irritable Bowel Disease (IBD)	0.6	1.5	7.0	-0.4	0.0	0.4	-2.6	-0.5
Blood Platelet Count	0.6	7.4	13.8	1.6	3.7	3.4	1.7	2.5
Blood Red Count	0.6	6.2	11.5	-2.5	-1.7	-2.4	-2.2	-3.4
Allergy or Eczema	0.6	1.6	3.2	-1.6	-1.3	-1.8	-0.5	0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.5	-1.2	1.2	0.1	1.0	0.3
Relative age of first facial hair	0.6	1.1	3.1	1.3	1.8	0.1	0.4	0.9
Medication: Co-codamol	0.6	0.7	1.6	1.3	0.4	1.1	0.1	0.7
Sitting height	0.6	4.4	8.4	1.4	-2.4	1.9	-2.9	-1.5
Impedance of leg (left)	0.6	2.9	11.8	0.1	-0.9	-1.4	3.4	0.2
Allergy	0.6	1.3	2.2	1.5	0.8	1.5	1.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	6.9	1.5	-0.8	2.6	0.3	0.0
Pulse wave reflection index	0.6	0.8	2.0	0.5	1.4	0.9	-0.9	-0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	-0.8	0.3	-0.9	1.3	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.2	1.3	0.3	1.5	-0.3	-0.0
Forced vital capacity (FVC), Best measure	0.6	2.4	8.1	1.7	-0.7	2.9	0.1	0.6
Exposure to tobacco smoke outside home	0.6	0.7	1.5	-0.8	-0.7	-0.3	-1.0	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.3	0.3	-1.2	-0.4	-0.6	-1.1
Neck or shoulder pain in last month	0.6	0.9	2.1	0.7	0.1	1.4	0.8	1.1
Illnesses of father: High blood pressure	0.6	0.8	2.2	-0.6	0.8	-1.5	0.7	-0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.0	1.4	0.7	0.9	0.3	0.3
Fractured/broken bones in last 5 years	0.6	0.7	1.2	1.0	-0.7	0.8	1.1	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	-1.2	-0.9	-1.1	0.1	-0.3
Bipolar Disorder (2018)	0.5	0.8	1.5	0.4	-1.0	1.2	-1.2	-0.0
Neuroticism (Nagel 2018)	0.5	1.1	2.9	-1.0	1.7	-1.1	0.2	0.2
Worry (Nagel 2018)	0.5	1.0	2.1	-0.9	1.5	-0.9	0.1	1.2
Alzheimer’s Disease (in father)	0.5	0.5	1.0	0.8	-0.5	1.0	0.7	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.3	1.1	1.5	1.2	0.8	0.7
Mean Putamen Volume	0.5	0.6	2.2	-0.5	0.4	-1.5	0.3	0.4
LDL Cholesterol	0.5	0.7	1.9	-0.3	1.4	0.8	0.2	1.1
BMI	0.5	2.9	9.6	0.2	0.9	1.7	-3.1	-0.8
Height	0.5	10.1	19.8	0.1	-4.5	0.1	-4.3	-3.5
Waist Hip Ratio (WHR)	0.5	2.2	4.7	-0.3	-0.6	-2.2	1.7	-1.8
Severe depression (siblings)	0.5	0.5	1.4	-0.9	0.4	0.1	-0.5	1.2
Fed-up feelings	0.5	0.9	1.5	-1.2	1.0	-1.2	0.6	-0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	-0.2	-1.3	-0.5	0.2	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	1.5	-1.1	0.7	-1.2	0.1	-0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.0	0.3	0.6	-1.4	0.9	0.2
Arm fat percentage (right)	0.5	1.8	5.2	-1.3	1.4	0.2	-2.3	0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.4	-1.0	-0.7	-1.2	-0.6	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.3	1.0	-0.1	-0.2	1.5	-0.1
Depression (self-reported)	0.5	0.6	1.0	-0.3	1.0	1.0	-0.8	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	-0.0	-1.4	1.1	0.4	-0.8
Headache pain in last month	0.5	0.8	2.3	0.3	-1.5	0.5	0.5	-1.1
Leg fat percentage (right)	0.5	1.8	5.6	-0.7	1.6	0.4	-2.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	-1.3	0.3	-1.0	-0.2	-0.7
Mean time to correctly identify matches	0.5	1.0	4.0	-0.2	0.5	-0.8	-2.0	0.1
Suffer from ‘nerves’	0.5	0.7	2.9	0.4	0.0	0.4	1.7	0.7
Chest pain or discomfort	0.5	0.8	1.4	0.2	-1.2	0.1	-1.2	-1.0
Family relationship satisfaction	0.5	0.7	1.5	0.5	-1.0	-0.3	-0.7	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-1.0	-0.2	-1.0	-1.1	-0.0
Knee pain experienced in last month	0.5	0.8	1.8	-0.5	0.6	-0.8	-1.1	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.2	-1.1	-0.9	-0.1	-0.7	0.5
Hearing aid user	0.5	0.6	1.7	-1.3	-0.5	-0.7	-0.5	0.6
Financial situation satisfaction	0.5	0.6	1.3	0.7	0.1	1.1	-1.0	-0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	0.5	-0.5	1.4	-0.7	-0.4
Medication: Lisinopril	0.5	0.6	1.6	-0.0	0.6	0.0	-1.1	1.3
Ever smoked	0.5	0.9	1.4	0.2	-1.1	1.2	1.1	-1.0
Leg fat percentage (left)	0.5	1.8	6.7	-0.5	1.3	0.7	-2.6	0.2
Depression (Nagel 2018)	0.4	0.6	1.7	-1.3	1.0	0.4	-0.0	-0.2
Ovarian Cancer	0.4	0.5	2.1	-0.1	-0.4	0.3	1.4	0.5
Prostate Cancer	0.4	0.5	0.9	-1.0	0.9	-0.7	0.1	-0.5
Crohns Disease (2012)	0.4	0.7	1.5	-0.6	-0.7	-0.6	1.2	0.8
Primary Biliary Cirrhosis	0.4	0.6	2.3	-1.5	-0.7	-0.1	-0.0	0.3
Rheumatoid Arthritis	0.4	0.5	1.6	-0.7	-0.1	-0.5	1.2	0.4
Lung FVC	0.4	2.1	5.4	0.8	0.5	2.1	-0.2	2.3
Sensitivity / hurt feelings	0.4	0.7	1.7	0.2	1.2	0.3	1.3	0.3
Trunk fat percentage	0.4	1.5	5.1	-1.4	0.7	-0.2	-2.3	-0.3
Hand grip strength (right)	0.4	1.0	2.6	-0.9	0.0	-0.8	-1.6	-0.9
Average weekly fortified wine intake	0.4	0.4	1.0	-0.6	0.4	0.5	-1.0	-0.6
Past tobacco smoking	0.4	0.8	3.3	-0.7	0.3	-1.8	-0.3	0.2
Forced vital capacity (FVC)	0.4	1.6	5.2	1.4	-0.7	2.3	0.0	0.5
Financial difficulties in last 2 years	0.4	0.5	1.8	-0.7	-0.1	-0.5	1.3	-0.3
Time employed in main current job	0.4	0.4	1.7	-0.0	-0.3	-0.3	1.3	0.3
Father’s age at death	0.4	0.5	1.1	0.2	-1.0	-0.4	0.4	-1.0
Number of live births	0.4	0.6	2.4	0.4	0.2	0.5	1.5	-0.5
Length of working week for main job	0.4	0.4	1.0	-1.0	0.4	-0.4	-1.0	0.3
Gout (self-reported)	0.4	0.5	1.3	-1.1	-0.6	-0.1	-0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.5	-0.4	1.2	-0.6	-0.6	-0.4
Body fat percentage	0.4	1.6	5.6	-1.1	1.1	0.1	-2.4	-0.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.1	-1.1	0.2	-0.4	-1.0	-1.0
Emphysema/chronic bronchitis	0.4	0.4	1.1	-0.3	0.5	-0.8	1.1	0.4
Comparative height size at age 10	0.4	2.0	5.4	0.7	-0.3	2.0	-2.3	-0.1
Overall health rating	0.4	0.9	3.5	-0.3	-1.0	-0.1	-1.9	-0.4
Illnesses of father: Heart disease	0.4	0.6	1.1	-0.5	0.5	-1.1	-0.7	0.9
Arm fat percentage (left)	0.4	1.6	4.4	-1.2	1.3	0.2	-2.1	0.2
Back pain experienced in last month	0.4	0.5	1.2	-0.1	-1.1	0.6	-1.1	-0.0
Alcohol drinker status: Never	0.4	0.5	1.2	-0.6	-0.6	-0.0	1.1	0.8
Schizophrenia (2018)	0.3	0.6	1.8	0.8	-0.5	0.4	1.3	0.1
Breast Cancer	0.3	0.6	1.7	1.3	-0.0	0.7	0.7	0.6
Neuroticism (2016)	0.3	0.4	0.9	-0.7	0.8	-1.0	-0.1	0.0
Average weekly spirits intake	0.3	0.4	0.8	-0.4	-0.8	-0.3	-0.6	-0.9
Medication for hormone replacement therapy	0.3	0.4	1.0	-0.3	-0.4	0.3	-0.7	1.0
Pack years adult smoking proportion	0.3	0.4	1.4	-0.7	-0.3	-1.2	0.2	-0.3
Hearing difficulty/problems with background noise	0.3	0.5	1.3	0.0	0.5	1.0	-1.2	0.1
Illnesses of siblings	0.3	0.4	1.3	-0.3	0.0	0.7	1.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.6	1.2	-0.5	1.9	0.3	0.3
Happiness	0.3	0.3	0.8	0.4	-0.2	0.8	-0.1	-0.9
Tense / ‘highly strung’	0.3	0.5	0.8	-0.7	0.6	-0.6	0.8	0.9
Age at first live birth	0.3	0.5	1.2	0.3	0.5	0.6	-0.7	1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.0	-0.5	0.4	0.4	-0.4	1.0
Medication: Allopurinol	0.3	0.4	0.8	-0.7	-0.4	-0.0	0.5	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.8	0.1	-0.8	-0.3	0.6
Mood swings	0.3	0.6	2.2	-1.5	0.4	-0.9	-0.2	0.0
Friendships satisfaction	0.3	0.3	0.8	0.2	0.9	-0.7	-0.5	0.4
Guilty feelings	0.3	0.4	1.1	-0.2	0.1	-0.9	1.0	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-0.5	0.4	-0.3	1.2	0.5
Irritability	0.3	0.4	1.5	-0.3	0.4	-0.6	-0.3	-1.2
Cholesterol lowering medication	0.3	0.5	1.8	-0.1	0.4	0.3	-1.3	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	0.7	-1.1	1.0	0.3	0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.2	-0.9	1.1	-0.6	0.4	0.2
Crohns Disease (2017)	0.2	0.4	1.2	-1.1	-0.8	-0.2	-0.3	0.4
Body Mass Index (BMI) (2010)	0.2	0.3	1.3	-0.2	0.6	0.0	-1.1	0.1
HDL Cholesterol	0.2	0.3	0.7	-0.8	-0.4	0.6	-0.3	0.2
Schizophrenia (2014)	0.2	0.5	1.8	-0.0	-0.6	0.3	1.4	-0.4
Blood Eosinophil Count	0.2	1.5	2.9	1.5	0.8	0.7	-1.7	1.1
Hand grip strength (left)	0.2	0.6	2.1	0.5	0.8	0.3	-1.4	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-1.1	0.0	0.0	0.2	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	0.3	-0.6	0.3	-0.0	-0.7
Supplements: Zinc	0.2	0.2	0.5	0.7	0.4	0.4	-0.3	-0.5
Diabetes (father)	0.2	0.3	0.4	0.5	0.5	0.1	-0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.8	0.8	-0.4	-0.2	-0.0
Age when periods started (menarche)	0.2	0.4	1.4	0.7	-0.2	0.1	1.2	-0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.0	0.8	-0.3	0.2	-0.1
Stomach or abdominal pain in last month	0.2	0.3	0.7	-0.8	-0.3	-0.4	-0.0	-0.7
Number of incorrect matches in round	0.2	0.3	1.3	0.3	1.1	-0.1	0.3	0.4
Qualifications: None of the above	0.2	0.4	1.1	1.1	0.5	0.2	0.1	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.3	-0.5	-0.8	-0.7	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.8	-0.1	-0.3	1.3	-0.2	-0.2
Asthma	0.2	0.5	1.1	-0.7	-0.2	-0.8	0.1	-1.0
Illnesses of mother	0.2	0.2	0.3	-0.0	-0.4	0.5	0.4	-0.6
Blood clot in the leg (DVT)	0.2	0.2	0.7	-0.0	0.5	-0.4	-0.3	-0.9
Qualifications: College or University degree	0.2	0.6	2.1	0.3	-0.2	1.5	-0.6	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.8	0.7	-0.4	0.2	0.1
Leg pain on walking	0.2	0.2	0.5	-0.6	-0.2	-0.7	-0.4	0.0
Loneliness, isolation	0.2	0.2	0.8	-0.2	0.5	-0.1	0.9	-0.2
Asthma (self-reported)	0.2	0.4	0.7	-0.7	-0.2	-0.8	-0.2	-0.8
Medication: Gliclazide	0.2	0.2	0.5	-0.1	0.3	-0.7	-0.7	0.0
Mother’s age at death	0.2	0.2	0.8	0.1	-0.1	0.6	-0.9	-0.2
Pain experienced in last month	0.2	0.3	0.6	0.7	0.4	-0.0	-0.8	-0.1
Heart disease (siblings)	0.2	0.3	1.4	-1.2	0.0	-0.3	-0.3	0.0
Blood White Count	0.1	1.0	3.1	0.1	0.8	0.3	-1.8	-1.0
Respiratory disease	0.1	0.2	0.5	-0.4	0.3	-0.3	-0.5	-0.7
Lung FEV1/FVC ratio	0.1	0.7	2.8	-0.6	0.1	0.1	1.7	-0.7
Hair Pigment	0.1	1.7	3.2	1.4	-1.6	0.2	-0.9	-1.8
Tanning	0.1	1.3	2.5	-0.2	1.4	0.8	1.1	1.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	-0.6	-0.9	-0.1	-0.3	-0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.3	0.5	-0.2	-0.6	0.6	0.6
Migraine (self-reported)	0.1	0.2	0.4	-0.4	0.1	0.5	0.3	0.6
Commuting to job workplace: Public transport	0.1	0.2	0.4	-0.2	-0.5	-0.1	-0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.2	0.4	-0.4	-0.4	-0.6
Pack years of smoking	0.1	0.2	0.9	-0.4	-0.1	-0.9	0.1	-0.0

Hub : Genes

TANC1

Models

Trait associations