Best TWAS P=2.4e-15 · Best GWAS P=1.04e-14 conditioned to 0.776
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NAB1 | 0.06 | 0.06 | lasso | 2 | 0.04 | 4.3e-06 | -7.16 | 7.5 | 4.7e-14 | -0.74 | 0.21 | 0.79 | FALSE |
2 | GTEx | Adipose Visceral Omentum | NAB1 | 0.15 | 0.00 | lasso | 3 | 0.00 | 2.5e-01 | -7.52 | -7.9 | 2.4e-15 | 0.84 | 0.03 | 0.58 | TRUE |
3 | GTEx | Artery Aorta | AC005540.3 | 0.18 | 0.12 | enet | 22 | 0.18 | 2.9e-10 | 4.45 | 5.8 | 7.9e-09 | -0.41 | 0.81 | 0.11 | FALSE |
4 | GTEx | Artery Tibial | MFSD6 | 0.26 | 0.12 | enet | 25 | 0.22 | 3.2e-17 | 0.29 | 5.8 | 7.7e-09 | -0.16 | 1.00 | 0.00 | TRUE |
5 | GTEx | Artery Tibial | AC067945.4 | 0.09 | 0.02 | lasso | 4 | 0.02 | 7.2e-03 | -6.09 | 6.7 | 2.5e-11 | -0.58 | 0.13 | 0.23 | FALSE |
6 | GTEx | Artery Tibial | AC005540.3 | 0.10 | 0.09 | lasso | 4 | 0.08 | 7.4e-07 | -4.59 | 6.3 | 3.2e-10 | -0.63 | 0.47 | 0.47 | FALSE |
7 | GTEx | Breast Mammary Tissue (Female) | INPP1 | 0.16 | 0.02 | lasso | 4 | 0.03 | 5.2e-02 | -5.60 | 6.7 | 1.9e-11 | -0.65 | 0.04 | 0.42 | FALSE |
8 | GTEx | Esophagus Mucosa | GLS | 0.07 | 0.01 | lasso | 6 | 0.01 | 5.4e-02 | -6.73 | -6.6 | 4.5e-11 | 0.77 | 0.10 | 0.15 | FALSE |
9 | GTEx | Muscle Skeletal | GLS | 0.09 | 0.06 | enet | 21 | 0.05 | 1.0e-05 | -4.59 | -5.3 | 1.2e-07 | 0.47 | 0.96 | 0.04 | FALSE |
10 | GTEx | Testis | NAB1 | 0.14 | 0.06 | enet | 20 | 0.10 | 5.1e-05 | -6.49 | -6.7 | 2.3e-11 | 0.78 | 0.08 | 0.90 | FALSE |
11 | GTEx | Testis | AC067945.4 | 0.20 | 0.15 | enet | 16 | 0.15 | 4.6e-07 | -3.71 | 5.3 | 1.4e-07 | -0.53 | 0.72 | 0.24 | FALSE |
12 | GTEx | Thyroid | AC005540.3 | 0.09 | 0.07 | enet | 5 | 0.04 | 2.5e-04 | -4.59 | 6.0 | 1.9e-09 | -0.60 | 0.20 | 0.75 | FALSE |
13 | YFS | Blood | GLS | 0.08 | 0.08 | lasso | 8 | 0.08 | 4.7e-26 | -4.59 | -6.1 | 1.1e-09 | 0.60 | 1.00 | 0.00 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GLS | 0.02 | 0.01 | enet | 6 | 0.02 | 9.6e-05 | 4.45 | -6.2 | 5.9e-10 | 0.69 | 0.11 | 0.82 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | GLS | 0.02 | 0.01 | blup | 68 | 0.01 | 9.7e-03 | -6.69 | -6.3 | 3.1e-10 | 0.75 | 0.03 | 0.48 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GLS | 0.16 | 0.07 | lasso | 6 | 0.11 | 1.3e-11 | -4.59 | -6.1 | 9.5e-10 | 0.61 | 0.19 | 0.81 | FALSE |