Hub : Genes

NAB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0250 6.9e-05 0.062 0.041 0.027 0.043 0.044 4.3e-08 7.9e-06 2.9e-04 5.3e-06 4.3e-06
2 GTEx Adipose Visceral Omentum 0.1510 0.0740 5.6e-03 0.004 NA -0.004 NA 0.002 1.8e-01 NA 6.0e-01 NA 2.5e-01
3 GTEx Esophagus Mucosa 0.3410 0.0620 2.2e-15 0.278 NA 0.277 NA 0.289 9.2e-19 NA 1.0e-18 NA 1.3e-19
4 GTEx Esophagus Muscularis 0.1270 0.0520 2.1e-03 0.128 NA 0.080 NA 0.117 3.5e-08 NA 1.3e-05 NA 1.4e-07
5 GTEx Testis 0.1440 0.0510 1.5e-04 0.056 NA 0.096 NA 0.084 1.6e-03 NA 5.1e-05 NA 1.4e-04
6 TCGA Cervical Squamous Cell Carcinoma 0.1190 0.0570 3.3e-03 0.051 0.041 0.055 NA 0.056 1.6e-03 4.4e-03 1.1e-03 NA 9.4e-04
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0557 0.0262 5.6e-04 0.036 0.021 0.031 NA 0.034 5.4e-05 1.6e-03 2.0e-04 NA 9.8e-05
8 TCGA Kidney Renal Papillary Cell Carcinoma 0.0480 0.0260 8.0e-03 0.023 0.038 0.031 NA 0.029 1.7e-02 2.9e-03 7.0e-03 NA 8.8e-03
9 TCGA Pancreatic Adenocarcinoma 0.1330 0.0760 1.0e-02 0.018 0.046 0.010 NA 0.019 5.7e-02 5.1e-03 1.2e-01 NA 5.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.1 0.1 0.4 -0.1 0.4 0.0 0.7 0.2 -0.5 -0.5 -0.3 0.4
Bipolar Disorder or Schizophrenia 0.7 1.6 6.5 -0.5 1.5 -0.6 -0.3 1.1 -1.5 -2.5 -1.4 0.1
Depressed Affect (Nagel 2018) 0.7 1.4 3.2 -0.6 1.1 -0.8 -0.1 1.7 -1.2 -1.7 -1.8 -0.2
Depression (Nagel 2018) 1.3 1.9 4.5 -0.9 1.5 -0.4 -0.2 1.9 -1.3 -2.1 -2.0 -0.5
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.8 -0.4 1.2 -1.7 -0.7 0.9 0.8 0.6 -0.6 0.3
Neuroticism (Nagel 2018) 1.4 3.3 6.3 -1.6 1.2 -0.8 -0.7 2.3 -2.4 -1.9 -2.5 -2.0
Schizophrenia (2018) 1.0 2.1 8.4 -0.6 1.5 -0.8 -0.9 1.3 -1.6 -2.9 -1.6 -0.2
Schizophrenia vs Biploar Disorder 0.8 1.1 3.5 -1.5 1.4 -0.9 0.7 1.9 -0.2 -0.6 -0.1 0.1
Worry (Nagel 2018) 0.8 1.6 7.7 -0.8 0.4 -0.4 -1.1 0.9 -1.8 0.1 -0.9 -2.8
Alzheimer’s Disease (in mother) 2.3 2.7 8.6 -0.4 0.9 1.2 -1.0 0.7 -2.0 -2.9 -2.4 -1.6
Alzheimer’s Disease (in father) 0.2 0.2 0.8 0.8 -0.3 0.9 -0.3 -0.1 0.3 -0.2 -0.0 0.4
Alzheimer’s Disease (including proxy) 0.8 1.2 3.4 0.2 0.7 0.7 -1.1 0.5 -1.6 -1.8 -1.3 -0.8
Crohns Disease (2017) 1.1 2.5 6.9 -0.1 -1.4 -0.2 0.3 -1.6 -2.6 -1.5 -1.5 -2.6
Irritable Bowel Disease (IBD) 0.1 0.3 1.0 0.1 -0.5 0.2 0.7 -1.0 -0.4 -0.7 -0.6 -0.0
Ulcerative Colitis (UC) 0.7 1.3 6.5 0.2 0.8 0.0 0.7 0.0 1.9 0.6 0.6 2.5
Major Depression (MDD) 1.3 1.6 4.7 -0.8 1.5 0.6 -0.1 2.2 0.6 -1.6 -1.7 0.3
Reaction Time 1.6 3.1 6.6 1.2 -2.5 -0.4 -0.9 -2.6 -2.4 -2.1 -0.7 -1.4
Verbal and Numeric Reasoning (VNR) 0.4 0.9 3.3 -0.8 1.1 -1.8 0.2 1.4 0.2 0.4 -0.4 0.6
Breast Cancer 1.1 2.6 9.4 2.4 -2.0 0.2 -0.9 -3.1 0.7 1.1 1.4 -0.0
Ovarian Cancer 0.3 0.4 1.1 0.0 0.3 -0.1 -0.4 0.7 1.1 0.7 1.0 0.4
Prostate Cancer 1.7 2.4 6.7 -1.0 1.6 -2.6 2.0 1.5 0.4 1.0 1.1 1.5
Age at First Birth 0.7 0.9 3.1 0.5 -0.6 -0.4 0.2 1.0 1.8 -0.6 0.8 1.6
Bipolar Disorder (2011) 1.9 1.8 5.9 -0.8 1.4 1.2 0.5 0.9 -0.9 -2.4 -2.1 -0.4
Body Mass Index (BMI) (2010) 0.6 0.9 2.6 -1.0 1.6 -0.3 0.9 1.4 -0.1 -0.6 -1.1 0.0
Coronary Artery Disease (CAD) 2.2 2.6 8.0 -2.2 1.5 -1.2 2.8 2.3 0.7 0.8 -0.6 0.5
Crohns Disease (2012) 1.2 2.0 5.6 -0.6 -0.6 -1.5 2.1 -0.5 -2.4 -0.4 -1.0 -1.8
Mean Putamen Volume 0.3 0.3 1.5 -0.3 -0.2 0.2 -0.2 0.2 1.2 -0.1 0.3 0.9
Fasting Glucose 0.4 0.5 2.7 0.3 0.8 0.6 1.6 0.4 0.3 0.1 -0.1 0.7
HbA1C 0.4 0.4 1.5 -0.2 0.3 0.9 -0.0 1.2 0.9 -0.2 -0.5 -0.5
HDL Cholesterol 0.1 0.2 0.8 0.0 -0.4 0.9 0.0 -0.7 0.3 -0.0 0.2 0.6
LDL Cholesterol 2.1 3.3 9.4 1.8 -0.4 1.5 -1.1 -0.9 3.1 2.1 2.2 1.8
Lupus 17.9 27.2 75.9 -8.7 5.6 -2.0 3.5 6.4 -3.1 -3.1 -6.2 -4.7
Neuroticism (2016) 0.8 1.1 4.2 -0.1 0.1 -0.5 0.5 1.0 -2.1 -1.6 -1.0 -0.8
Primary Biliary Cirrhosis 11.7 16.6 38.6 -4.6 1.2 -2.0 2.1 1.5 -5.8 -3.6 -5.7 -6.2
Rheumatoid Arthritis 7.8 10.7 23.4 -4.8 3.0 1.2 1.5 4.2 -1.2 -2.9 -4.5 -3.4
Schizophrenia (2014) 1.4 3.1 7.9 -1.6 1.9 -1.0 0.2 2.2 -1.9 -2.8 -2.0 -0.4
Triglycerides 2.6 4.3 13.5 2.3 -0.9 1.0 -0.5 -1.4 3.7 1.7 2.3 2.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 -0.2 0.5 0.4 -1.2 1.0 1.1 -0.8 -0.6 -0.1
Ulcerative Colitis 0.8 1.1 3.6 0.2 -0.0 -0.5 1.4 0.0 1.2 1.2 1.1 1.9
Blood Eosinophil Count 1.1 8.7 17.6 4.2 -3.2 0.3 -3.0 -3.5 2.1 1.6 3.3 3.3
Blood Platelet Count 1.5 17.2 40.3 4.9 -1.1 -0.7 -1.6 -0.8 5.4 4.9 5.7 6.3
Blood Red Count 1.0 9.3 17.3 4.0 -4.2 0.1 -2.8 -3.4 1.0 3.7 3.8 1.1
Blood White Count 0.7 5.4 11.2 3.2 -3.3 0.5 -3.3 -0.5 2.1 1.3 2.3 2.1
Heel T-Score 3.3 26.3 62.7 7.5 -7.9 -2.4 -4.6 -6.7 1.7 3.6 5.0 2.0
BMI 0.1 0.6 2.8 0.0 -1.7 -0.0 0.7 -1.4 -0.5 0.5 0.3 -0.0
Height 1.2 23.0 62.9 -7.5 5.8 -3.2 3.1 7.9 -2.8 0.0 -3.2 -4.0
Waist Hip Ratio (WHR) 0.2 1.1 3.4 -0.2 1.5 1.8 -0.7 1.3 1.0 -0.5 -0.9 -0.1
Systolic Blood Pressure 4.8 24.2 49.7 5.8 -6.8 -0.3 -1.9 -6.9 1.1 5.8 7.0 1.4
Smoking Status 0.3 0.8 3.6 -0.1 0.7 1.0 -0.4 -0.1 -0.2 -1.9 -1.1 -0.6
Allergy or Eczema 1.8 4.7 17.4 0.6 -1.6 -3.7 0.6 -1.3 -4.2 -0.6 0.2 -2.5
Cardiovascular Disease 2.0 6.7 16.5 2.7 -4.0 -1.9 -1.3 -4.1 -1.9 2.0 2.9 0.1
Hypothyroidism (self reported) 9.3 21.3 41.6 -6.5 5.0 -1.5 4.3 5.8 -3.3 -3.9 -5.7 -3.4
Respiratory disease 1.0 2.2 8.9 0.2 -1.2 -2.3 -0.4 -0.7 -3.0 -0.3 0.1 -1.8
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.9 -0.8 0.7 1.0 -0.5 1.3 1.4 -0.8 -0.7 0.4
Lung FEV1/FVC ratio 0.3 1.5 3.6 0.9 -1.8 -0.1 0.6 -1.9 -0.1 1.8 1.4 -0.1
Lung FVC 1.2 6.0 19.1 1.7 -2.9 -2.7 -1.8 -1.9 -0.9 4.4 2.8 -1.3
Neuroticism 0.5 1.3 2.9 -1.0 0.2 -0.8 -0.1 1.4 -1.7 -0.7 -1.4 -1.6
Chronotype (morning person) 2.0 4.7 13.9 1.6 -1.7 -1.0 1.5 -2.4 1.9 2.1 3.7 2.5
Hair Pigment 0.1 2.2 4.2 -2.0 0.8 2.0 1.5 1.0 -1.9 0.2 -0.9 -1.7
Tanning 0.0 0.4 1.2 0.1 -0.2 -0.6 1.1 -0.2 -0.0 0.4 0.9 1.0
Hand grip strength (left) 1.0 2.7 8.9 -2.5 1.9 1.6 0.7 3.0 -0.6 -1.2 -1.1 -0.1
Number of treatments/medications taken 1.0 1.8 5.2 -0.3 -0.8 -2.3 0.2 -0.5 -2.3 0.5 -0.2 -2.1
Average weekly spirits intake 2.1 2.7 9.3 0.4 -1.3 2.0 -2.2 -0.7 -0.9 -0.8 -1.5 -3.0
Sensitivity / hurt feelings 1.0 1.7 3.6 0.9 -1.6 -1.9 -1.9 -0.6 -1.6 0.5 0.3 -1.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.0 -0.4 0.7 -0.2 0.1 0.5 -1.3 -1.4 -1.3 -0.8
Hearing difficulty/problems: Yes 0.2 0.3 1.2 -0.7 0.4 -0.0 -0.0 0.3 1.1 1.0 0.1 -0.3
Relative age of first facial hair 0.4 0.9 2.5 -1.0 1.5 -0.7 -0.2 1.1 -1.6 -0.3 -0.3 -0.6
Other serious medical condition/disability diagnosed by doctor 3.8 4.9 9.5 -2.7 1.6 -2.2 0.8 2.8 -2.2 -2.0 -3.1 -1.7
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.0 0.8 -0.2 0.8 1.2 -1.7 0.5 0.9 1.0 1.0
Ever had hysterectomy (womb removed) 1.5 1.7 4.0 1.6 0.3 0.4 0.2 -1.5 1.3 1.2 1.9 2.0
Systolic blood pressure, automated reading 3.5 10.3 19.7 4.2 -4.3 -0.4 -1.9 -4.4 0.4 3.6 4.4 0.6
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 -1.0 0.9 0.3 0.7 1.3 1.3 0.3 0.4 0.5
Angina 0.9 1.2 2.2 1.1 -1.4 0.5 -0.7 -1.5 0.8 1.5 1.3 0.3
Medication for hormone replacement therapy 1.3 1.5 4.5 0.8 0.1 -0.3 0.4 -1.5 0.9 2.1 1.4 1.7
Vitamin and mineral supplements 1.7 2.3 5.1 1.5 0.1 0.9 1.1 -1.8 1.0 2.3 2.1 1.5
Supplements: Zinc 1.5 1.7 4.2 -1.6 1.5 -1.0 0.7 2.0 -0.2 -1.7 -1.2 0.6
Medication: Co-codamol 1.3 1.5 9.1 0.4 -0.8 -3.0 1.0 -1.0 -0.8 1.0 0.3 -0.2
Medication: Metformin 0.4 0.5 3.5 0.7 -1.9 0.4 -0.3 -0.3 0.5 -0.0 0.5 0.2
Diabetes (father) 1.0 1.2 3.1 -1.8 1.5 -0.3 1.4 1.3 -0.1 -0.5 -1.2 -0.5
Diabetes (mother) 0.6 0.7 1.8 1.4 -1.1 0.8 -1.2 -0.6 0.9 -0.6 -0.4 -0.2
Severe depression (siblings) 0.7 0.8 3.8 -0.5 0.7 -1.2 0.2 0.2 -2.0 -0.4 -0.7 -0.7
Pack years adult smoking proportion 0.8 1.2 3.4 0.6 -1.0 -1.8 1.1 -0.0 0.5 0.6 1.2 1.7
Impedance of leg (right) 0.1 0.5 1.2 0.4 0.2 -0.3 -0.3 -0.7 -1.0 -1.0 -0.7 -1.1
Leg fat-free mass (left) 0.3 1.4 4.0 -1.9 0.6 -0.4 1.8 2.0 -0.2 0.8 0.3 0.2
Trunk fat percentage 0.5 2.0 5.9 0.6 -2.4 0.2 1.6 -2.4 -1.3 0.7 0.8 -1.0
Hand grip strength (right) 1.0 2.7 7.1 -1.9 2.1 2.2 0.2 2.7 0.2 -1.4 -1.6 -0.1
Townsend deprivation index at recruitment 0.4 0.6 2.6 0.3 -0.6 -0.2 0.3 -0.1 0.5 0.8 1.6 1.2
Current tobacco smoking 0.3 0.4 2.3 -0.1 -0.3 -1.0 1.5 -0.4 -0.3 0.1 0.3 0.2
Average weekly fortified wine intake 0.7 0.8 3.2 -0.8 1.3 -1.8 0.6 0.3 -0.8 0.4 -0.2 -0.5
Maternal smoking around birth 0.4 0.6 1.8 -0.5 -0.3 0.4 -1.2 0.8 0.0 -0.8 -1.3 -0.7
Fed-up feelings 0.4 0.7 4.0 0.3 -0.4 -0.0 -2.0 0.3 -0.1 -0.4 -1.1 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.7 -0.0 0.8 -0.6 0.2 0.2 -0.5 -0.1 -0.1 0.6
Relative age voice broke 0.2 0.4 1.1 0.5 -0.6 0.1 -1.0 -0.4 -1.0 -0.5 0.3 -0.5
Taking other prescription medications 1.6 2.4 12.6 -0.9 0.0 -3.5 0.3 1.1 -1.8 1.2 -0.1 -1.5
Age when periods started (menarche) 1.8 4.2 9.5 2.3 -2.4 -0.9 0.4 -3.1 0.3 2.7 3.0 0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 -0.2 0.6 1.3 1.2 -0.0 1.2 0.9 0.5 1.0
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.5 9.6 2.9 -3.1 -0.4 -1.0 -1.4 2.0 2.1 2.5 2.1
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 4.0 -0.8 1.8 0.3 0.9 1.2 1.4 0.8 0.6 2.0
Qualifications: CSEs or equivalent 0.2 0.2 0.6 0.1 -0.1 -0.7 -0.0 -0.8 -0.4 0.7 0.4 0.3
Serious illness, injury or assault to yourself 1.2 1.4 4.7 -1.5 1.1 -0.1 0.2 2.2 0.1 -1.4 -1.6 -0.3
High blood pressure 1.2 3.5 9.1 2.1 -3.0 -1.2 -1.2 -2.6 -1.8 1.0 2.0 -0.1
Hayfever, allergic rhinitis or eczema 1.7 3.8 14.3 0.3 -0.9 -3.8 1.0 -1.1 -3.5 -0.5 -0.2 -2.1
Multivitamins +/- minerals 2.6 3.3 11.2 -0.8 0.1 -1.1 -1.4 1.0 -2.2 -3.4 -2.5 -1.6
Stomach or abdominal pain in last month 0.8 1.0 2.4 -1.2 0.5 -0.6 -0.4 0.1 -1.5 0.1 -1.4 -1.5
Supplements: Glucosamine 0.6 0.7 2.0 -0.9 -0.3 -0.5 1.2 -0.6 -1.4 -0.5 -0.7 -1.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 0.4 0.8 -0.6 -0.4 0.0 0.3 -0.3 -0.5 0.5
Medication: Atenolol 1.2 1.6 3.8 0.7 -1.4 -1.2 0.7 -1.9 -0.4 1.8 1.4 -0.0
Medication: Levothyroxine sodium 7.9 13.4 28.9 -5.4 4.6 -1.6 3.5 5.4 -1.3 -2.1 -4.1 -1.9
Sitting height 0.8 5.9 16.5 -3.7 2.8 -1.8 3.3 4.1 -0.5 0.8 -0.1 -0.1
Chronic bronchitis/emphysema (father) 2.0 2.4 10.5 1.9 -1.5 -0.8 0.2 -3.2 -0.9 0.9 1.6 0.4
High blood pressure (mother) 1.2 1.7 5.2 0.2 -1.3 0.8 0.9 -0.3 1.6 2.3 1.8 1.1
Body mass index (BMI) 0.2 0.8 3.5 0.5 -1.9 0.9 0.1 -1.5 -0.6 0.1 0.1 -0.3
Impedance of leg (left) 0.0 0.2 0.5 0.4 0.0 0.2 -0.1 -0.6 -0.4 -0.7 -0.5 -0.7
Leg predicted mass (left) 0.3 1.4 4.0 -1.9 0.5 -0.4 1.8 2.0 -0.4 0.7 0.2 0.1
Trunk fat mass 0.3 1.1 2.8 -0.2 -1.6 0.1 1.7 -1.1 -1.4 0.5 0.4 -1.1
Waist circumference 0.1 0.3 0.6 -0.2 -0.6 0.7 -0.2 -0.2 -0.8 0.0 -0.5 -0.8
Number of incorrect matches in round 0.7 1.2 3.6 -0.8 1.2 -1.9 0.1 0.2 -1.2 -1.6 -0.8 0.6
Past tobacco smoking 0.4 0.8 2.8 -0.5 -0.7 -1.7 1.1 1.0 -0.7 0.8 0.4 0.3
Alcohol usually taken with meals 2.0 3.2 7.4 -1.7 1.3 -1.1 0.3 2.2 -1.6 -2.4 -2.7 -1.4
Nervous feelings 0.3 0.6 1.8 0.3 -0.2 -0.1 -1.3 -0.1 -0.4 1.3 0.9 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.6 -0.4 -0.3 -0.7 -1.9 0.4 -1.6 -1.1 -1.3 -1.7
Hearing difficulty/problems with background noise 0.4 0.6 2.1 -0.8 0.7 -1.4 -0.8 0.6 -0.4 -0.1 -0.8 -0.7
Hair/balding pattern: Pattern 2 0.9 1.2 3.6 0.0 0.4 1.6 0.9 0.6 1.6 0.5 0.3 1.9
Had menopause 1.1 1.4 6.6 -0.4 0.5 0.1 -0.2 -0.5 -1.8 -0.4 -1.2 -2.6
Had other major operations 0.6 0.8 2.9 0.3 -0.0 -1.6 -0.5 -0.6 0.2 1.7 0.8 0.1
Forced vital capacity (FVC) 1.3 5.2 14.1 -3.8 2.2 -2.7 1.8 3.6 -0.9 1.5 -0.4 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 10.5 2.9 -3.2 -1.6 -1.5 -1.2 1.0 1.7 2.5 1.7
Ever unenthusiastic/disinterested for a whole week 1.8 2.1 7.2 -1.6 2.0 0.2 1.9 2.7 0.6 -0.5 -0.8 1.0
Qualifications: None of the above 3.2 6.8 14.6 3.5 -2.8 0.2 -1.6 -3.8 1.0 2.5 3.7 1.7
Financial difficulties in last 2 years 0.8 1.1 4.8 1.0 -0.3 -1.6 0.4 -1.1 -2.2 0.1 0.4 0.0
Mouth/teeth dental problems 0.9 1.3 2.2 0.8 1.4 1.2 1.1 -1.4 1.2 -0.9 0.4 1.5
Heart attack 0.4 0.5 1.8 0.6 -0.6 -0.7 0.0 -0.2 0.1 1.2 1.3 0.5
Allergy 2.5 5.7 20.6 -0.6 1.6 3.9 -0.0 1.9 4.5 0.6 0.4 3.0
Pain all over the body in last month 1.9 2.1 6.2 2.5 -1.1 -0.3 -1.9 -2.0 0.5 1.1 1.2 0.9
Diabetes (self-reported) 0.3 0.5 1.2 -0.2 -0.1 0.8 0.3 0.7 1.0 -1.1 -0.3 0.9
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 6.5 0.6 -0.3 -2.6 -0.2 -0.8 -2.4 0.3 0.0 -1.4
Medication: Ramipril 0.8 1.1 3.8 0.5 -0.2 0.1 -1.9 -0.5 1.4 1.3 0.9 0.8
Medication: Simvastatin 2.3 3.4 5.7 2.0 -1.4 0.5 -1.0 -1.8 2.4 2.2 2.0 2.4
Fluid intelligence score 0.4 0.8 3.3 -0.7 1.0 -1.8 0.5 1.1 -0.1 -0.2 -0.7 0.6
Illnesses of siblings 0.9 1.2 4.1 -0.8 0.5 0.3 -0.2 0.7 -0.8 -1.4 -1.6 -2.0
Neuroticism score 0.4 0.7 2.2 -0.6 0.4 -0.8 -0.5 0.7 -1.5 -0.0 -0.8 -1.4
Weight 0.2 0.9 2.7 -1.6 -0.2 -0.3 1.7 0.9 -1.1 0.5 -0.0 -0.6
Impedance of arm (right) 0.6 2.9 5.6 0.9 -2.4 -2.3 0.8 -2.3 -1.6 1.3 1.1 -1.6
Arm fat percentage (right) 0.7 2.6 9.7 0.8 -3.1 0.2 0.2 -2.8 -1.8 0.5 0.4 -1.5
Trunk fat-free mass 0.7 3.8 15.6 -3.2 2.2 -0.4 1.6 4.0 -0.5 -0.1 -0.7 -0.0
Hip circumference 0.2 1.0 2.6 -1.5 -0.5 -0.7 1.4 0.1 -1.6 0.0 -0.8 -1.2
Time employed in main current job 1.0 1.2 4.5 0.6 -1.6 -2.1 -1.0 -0.5 -0.1 1.1 0.8 0.2
Alcohol intake versus 10 years previously 0.8 1.3 5.1 -0.9 0.9 -2.2 1.1 1.2 -1.0 0.3 0.6 0.7
Father’s age at death 0.3 0.4 2.1 -0.5 1.0 -1.4 0.1 -0.2 0.1 -0.4 -0.3 0.3
Worrier / anxious feelings 0.7 1.2 3.8 0.1 -1.1 -1.3 -0.8 -0.6 -1.7 0.7 -0.0 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.2 1.0 -1.5 -0.8 -0.4 -1.0 -0.2 1.5 1.1 0.3
Falls in the last year 1.4 1.9 5.1 -1.7 2.3 -1.2 1.3 1.6 -0.5 -1.4 -1.0 0.5
Hair/balding pattern: Pattern 3 0.7 1.0 2.2 -1.5 -0.1 -1.0 0.2 0.7 -0.8 -1.2 -1.3 -1.0
Number of live births 0.6 0.9 2.9 0.2 -0.1 -0.5 1.1 -0.3 0.4 1.5 1.7 1.1
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 5.9 -2.4 1.1 -1.9 1.4 2.2 -0.4 2.0 0.4 -0.5
Pulse rate 2.1 3.6 8.0 2.2 -2.6 0.1 -1.0 -2.3 0.0 2.4 2.8 0.5
Happiness 0.7 0.9 3.0 0.4 1.1 0.4 -0.6 0.4 0.3 -1.7 -1.1 1.2
Noisy workplace 0.5 0.6 2.0 -0.4 1.4 1.4 0.5 0.3 0.8 0.5 -0.2 0.6
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.8 -0.9 1.0 0.3 -0.1 1.4 0.3 0.1 -0.8 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.7 -0.0 -0.2 -1.0 1.3 0.2 -0.3 -0.3 0.1 0.9
Mouth/teeth dental problems: Dentures 0.9 1.4 3.7 0.3 -1.4 -1.9 0.1 -0.6 -1.3 1.9 1.2 -0.5
Asthma 1.1 2.2 7.5 0.7 -1.4 -2.7 -0.3 -1.0 -2.2 1.3 1.2 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 6.0 2.3 -1.4 -0.8 -1.7 -2.5 0.1 1.0 1.5 1.0
Medication: Cholesterol lowering 0.9 1.3 2.8 1.1 -1.7 -0.9 0.0 -1.6 -0.1 1.5 1.5 -0.4
Depression (self-reported) 4.2 5.1 11.9 -2.6 2.2 -0.8 -0.1 2.2 -1.8 -2.8 -3.5 -2.4
Medication: Lansoprazole 0.6 0.7 2.4 1.1 -0.3 -0.6 -1.6 -0.2 0.3 0.8 0.8 0.8
Prospective memory result 1.1 1.3 5.5 1.3 -0.3 2.3 -1.2 -1.0 1.2 0.0 0.6 0.4
Lung cancer (father) 1.2 1.4 2.9 -1.5 0.8 1.1 1.1 0.5 -0.6 -0.9 -1.6 -1.7
Illnesses of mother 0.1 0.1 0.2 -0.3 0.5 -0.2 -0.1 -0.1 0.2 -0.2 -0.3 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.1 4.8 -1.4 0.7 -1.9 1.8 1.1 -0.6 2.2 1.4 0.6
Pulse wave Arterial Stiffness index 0.4 0.4 2.4 0.7 -0.4 -0.4 -0.0 -1.5 -0.3 0.5 0.4 -0.3
Impedance of arm (left) 0.4 1.7 3.3 0.5 -1.4 -1.8 1.2 -1.8 -1.4 0.6 0.6 -1.5
Arm fat mass (right) 0.2 0.9 3.5 -0.1 -1.9 0.3 0.8 -1.1 -1.3 0.4 0.2 -1.0
Trunk predicted mass 0.7 3.9 16.5 -3.2 2.1 -0.4 1.6 4.1 -0.5 -0.1 -0.8 -0.0
Standing height 1.0 9.8 28.8 -4.6 3.6 -2.8 3.9 5.4 -1.2 0.8 -0.3 -0.5
Length of working week for main job 1.3 1.4 2.5 1.6 -1.1 0.5 -1.2 -1.4 1.2 0.5 1.3 1.4
Exposure to tobacco smoke at home 0.9 1.1 4.5 0.7 -0.2 -0.0 0.5 -0.4 0.8 0.7 1.7 2.1
Breastfed as a baby 0.5 0.6 1.6 -0.5 0.8 -1.3 0.6 1.2 -0.3 -0.8 -0.4 0.6
Tense / ‘highly strung’ 0.4 0.6 2.9 -0.3 -0.1 -0.3 -1.3 0.4 -0.5 0.3 -0.5 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.8 5.3 -2.1 1.3 -0.4 -0.8 1.9 -1.5 -1.5 -2.3 -2.2
Hair/balding pattern: Pattern 4 1.7 4.2 7.8 2.8 -2.5 2.3 -2.8 -2.7 -0.4 0.5 1.3 -1.0
Birth weight of first child 0.5 1.0 3.9 -0.2 1.3 0.2 2.0 0.7 0.7 0.4 0.4 1.2
Peak expiratory flow (PEF) 2.2 5.1 17.3 1.0 -1.6 -3.5 0.4 -1.6 -0.5 4.2 3.0 0.7
Pulse wave reflection index 0.8 0.9 2.2 0.3 0.1 -0.2 -0.7 -1.0 -1.5 -1.3 -1.3 -1.1
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.5 -0.0 1.1 0.5 0.4 1.3 1.0 1.3 1.0 1.6
Loud music exposure frequency 0.6 0.7 3.1 0.6 -0.4 1.2 -0.1 0.2 -0.6 -1.8 -0.8 0.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 5.3 1.9 -1.3 0.2 -2.3 -1.4 -0.1 -0.3 0.2 -0.8
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 4.9 -0.1 -2.2 -0.9 -1.1 0.6 -0.6 0.7 -0.2 -1.2
Blood clot in the leg (DVT) 0.1 0.2 0.5 -0.7 0.1 -0.1 0.0 -0.3 -0.1 0.0 -0.7 -0.5
Medication: Paracetamol 2.3 3.9 7.9 2.8 -2.7 -0.1 -2.2 -2.8 -1.2 1.2 1.3 -1.6
Headache pain in last month 0.5 0.8 1.8 0.5 -1.0 -0.8 -1.0 -1.2 -0.1 1.0 0.3 -1.3
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 3.8 -1.7 1.8 -0.1 0.4 1.9 -0.9 -1.8 -1.9 -0.7
Glaucoma (self-reported) 0.1 0.1 0.7 0.9 -0.2 -0.1 0.1 -0.4 -0.1 -0.1 0.2 -0.1
Gout (self-reported) 1.3 1.8 3.5 -1.6 0.0 0.3 0.3 1.2 -1.6 -1.8 -1.9 -1.8
Hypothyroidism/myxoedema (self-reported) 9.4 18.3 35.8 -6.0 4.6 -1.8 4.2 5.8 -2.4 -3.6 -5.1 -2.7
Medication: Amlodipine 1.6 2.3 6.6 0.6 -1.0 -2.6 0.2 -0.7 0.2 2.2 2.1 1.6
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.8 0.7 -1.2 -1.3 -0.6 -0.6 -0.7 0.2 -0.0 -1.0
Birth weight 1.9 4.2 13.1 -2.3 2.9 -0.0 0.6 3.6 0.4 -2.1 -2.4 -0.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.6 0.6 -0.5 0.1 -0.6 -0.6 -0.5 -1.2 -0.6 0.0
High blood pressure (siblings) 0.4 0.6 1.4 0.3 -0.6 1.0 0.7 -0.7 0.3 1.2 1.1 0.6
Forced vital capacity (FVC), Best measure 0.7 2.4 6.9 -1.8 0.8 -2.6 1.6 1.8 -1.1 1.8 1.1 0.1
Body fat percentage 0.5 1.8 5.8 0.8 -2.4 0.3 0.8 -2.4 -1.3 0.4 0.6 -1.0
Leg fat percentage (right) 0.4 1.6 4.8 1.0 -2.2 0.7 -0.6 -2.0 -1.4 -0.6 -0.2 -1.1
Arm fat-free mass (right) 0.7 3.5 12.7 -2.7 2.4 0.5 2.1 3.6 0.4 -0.0 -0.4 0.7
Exposure to tobacco smoke outside home 0.9 1.2 3.4 -1.1 1.1 -1.3 0.3 1.3 -1.8 -0.5 -0.9 -0.7
Comparative body size at age 10 0.5 1.3 3.0 -1.7 0.7 0.3 0.3 1.4 -1.0 -1.4 -1.5 -0.4
Number of full brothers 1.0 1.3 2.5 1.4 -0.8 -1.0 -0.0 -1.4 1.0 1.6 1.2 1.2
Worry too long after embarrassment 2.7 4.6 12.6 -1.4 0.8 -1.6 -0.5 1.1 -3.6 -2.3 -2.7 -3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 4.8 6.2 15.3 -3.7 3.9 -0.5 2.2 3.7 -0.9 -1.7 -2.0 -0.6
Wheeze or whistling in the chest in last year 1.4 2.5 10.1 -0.6 -0.8 -2.3 0.4 -0.2 -3.2 -0.9 -1.1 -1.9
Number of children fathered 1.2 1.3 4.6 -0.7 0.2 -0.3 -1.4 0.9 -0.2 -0.8 -1.8 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 3.5 1.6 -0.6 -1.5 -0.0 -1.3 -0.0 1.8 1.9 1.7
Age at first live birth 0.2 0.3 1.7 0.3 -1.3 -0.2 0.4 -0.3 0.2 0.2 0.2 -0.8
Pulse wave peak to peak time 0.7 0.9 4.2 -1.4 0.7 -0.1 0.4 2.1 -0.2 -0.6 -0.8 -0.1
Health satisfaction 0.7 0.9 4.0 -1.2 2.0 0.9 1.0 1.1 0.2 0.0 -0.2 0.0
Shortness of breath walking on level ground 0.6 0.7 1.9 0.4 -0.4 0.1 -0.4 0.1 1.4 1.2 1.0 1.2
Qualifications: College or University degree 2.5 7.9 15.8 -3.4 3.3 2.8 1.3 3.6 0.9 -2.9 -4.0 -0.9
Eye problems/disorders: None of the above 1.0 1.2 3.2 0.8 -1.4 1.2 -0.6 -1.8 -0.8 -0.2 0.2 -1.5
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.8 0.9 -1.0 0.8 -0.6 -0.3 1.4 -0.9 0.0 0.7
Emphysema/chronic bronchitis 1.3 1.5 4.3 0.5 -0.8 -1.4 -0.2 -1.3 -2.1 -1.3 -0.8 -1.5
Medication for pain relief, constipation, heartburn 1.5 2.5 4.9 -2.1 2.2 0.9 1.6 2.0 0.4 -1.6 -1.6 0.1
Neck or shoulder pain in last month 1.2 1.7 4.6 1.7 -1.2 -0.6 -2.1 -0.5 0.4 1.5 1.5 0.9
Medication: Blood pressure 1.6 2.8 4.4 2.0 -2.1 1.0 -1.4 -2.0 1.5 1.7 2.0 1.0
Angina (self-reported) 1.1 1.5 2.8 1.4 -1.6 0.4 -1.1 -1.7 0.8 1.5 1.3 0.3
Migraine (self-reported) 0.8 1.0 1.7 -1.2 1.0 -1.2 0.6 0.6 -1.2 0.3 -0.7 -1.3
Medication: Ibuprofen 1.9 2.3 6.4 2.5 -1.2 -1.0 -1.4 -2.5 -0.1 0.8 1.4 1.1
Medication: Allopurinol 2.0 2.7 7.2 -2.0 0.2 -0.6 -0.0 1.6 -2.7 -1.0 -1.6 -2.6
Medication: Omeprazole 0.1 0.2 0.4 -0.7 -0.5 0.4 0.3 0.4 0.3 0.4 -0.2 0.0
Medication: Seretide 50 evohaler 0.6 0.7 1.5 -0.9 0.8 -0.6 1.2 1.1 0.4 1.1 0.3 0.4
Mean time to correctly identify matches 1.0 2.0 5.6 1.3 -2.4 -0.3 -0.8 -2.4 -1.4 -1.3 -0.1 -0.7
Heart disease (mother) 0.2 0.3 1.5 0.1 0.1 -0.4 -0.2 -0.3 -1.2 -0.2 -0.6 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 4.8 -1.7 1.5 2.2 0.5 2.1 0.3 -1.9 -1.9 -0.5
Whole body fat mass 0.2 0.9 2.8 -0.1 -1.7 0.1 1.0 -1.2 -1.3 0.4 0.4 -1.0
Leg fat mass (right) 0.2 0.7 3.0 0.2 -1.7 0.7 0.2 -1.1 -1.1 0.2 0.1 -0.8
Arm predicted mass (right) 0.6 3.2 12.0 -2.6 2.3 0.4 1.9 3.5 0.4 -0.1 -0.4 0.7
Pulse rate, automated reading 4.2 13.7 27.9 4.7 -5.3 -0.1 -3.1 -4.0 0.3 4.7 5.0 -0.0
Alcohol intake frequency. 0.2 0.5 1.5 -0.2 0.2 -1.2 0.1 0.6 1.1 -0.3 0.1 1.2
Comparative height size at age 10 1.1 6.2 21.9 -3.6 3.4 -1.4 2.6 4.7 0.0 -0.3 -1.1 0.3
Number of full sisters 1.5 1.8 5.1 1.8 -0.6 0.1 0.3 -2.3 0.5 1.4 2.0 1.2
Suffer from ‘nerves’ 0.5 0.8 3.0 -0.3 -0.9 -0.6 -1.0 -0.2 -1.4 -0.0 -0.3 -1.7
Overall health rating 1.0 2.2 4.0 1.4 -1.7 -1.6 -1.1 -1.7 -1.3 2.0 1.5 -0.3
Chest pain or discomfort 1.0 1.5 4.7 -1.5 1.2 -0.3 2.2 1.2 0.3 0.8 0.4 1.6
Had major operations 2.5 2.9 10.4 -1.9 1.6 -3.2 2.5 0.6 -1.6 -0.1 -0.4 -0.3
Age at last live birth 0.1 0.2 0.5 0.4 -0.5 0.1 0.7 -0.5 0.6 -0.3 0.2 0.2
Family relationship satisfaction 0.9 1.1 3.8 -0.7 2.0 -0.1 0.7 0.8 -0.4 -1.4 -1.5 0.5
Leg pain on walking 0.9 1.1 3.1 -0.1 -0.1 -1.0 1.8 -1.2 0.1 1.4 1.2 1.2
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.2 -0.9 0.1 -2.1 0.0 0.8 -2.0 -0.2 -0.6 -0.9
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.9 -0.0 -0.1 -1.0 -0.6 1.0 1.3 1.7 1.0 0.2
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 3.3 -1.1 0.8 1.8 -0.4 0.0 0.1 -0.1 -0.6 -1.3
Medication: Aspirin 0.4 0.5 1.4 0.2 -1.2 0.4 -0.9 0.1 -0.9 0.1 0.2 -1.2
Supplements: Vitamin C 1.2 1.4 3.8 -1.5 1.2 -0.3 -0.3 1.8 2.0 -0.2 -0.4 1.1
Knee pain experienced in last month 1.2 1.9 4.4 -1.5 0.1 -1.0 -0.4 0.8 -2.0 -1.1 -2.1 -1.7
Hypertension (Self-reported) 1.0 2.7 6.6 1.6 -2.6 -1.3 -0.9 -2.4 -1.9 0.8 1.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.8 2.1 4.8 2.2 -2.0 0.2 -0.9 -1.7 0.9 0.8 1.8 1.3
Illnesses of father: Heart disease 0.5 0.7 2.1 0.8 -0.2 0.3 0.3 -1.5 -0.6 1.4 0.5 -1.1
Illnesses of siblings: Diabetes 0.5 0.6 2.6 0.6 -1.0 0.4 0.4 -0.8 0.8 -0.3 0.2 1.6
Smoking status: Previous 0.6 0.9 2.8 0.6 0.5 1.5 -1.7 -0.9 1.0 -0.8 -0.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 8.2 -2.9 0.9 -1.6 1.7 2.7 -0.5 0.5 -0.5 -0.5
Whole body fat-free mass 0.5 2.7 10.3 -2.7 1.6 -0.2 1.9 3.2 -0.2 0.3 -0.3 0.2
Leg fat-free mass (right) 0.3 1.6 4.5 -1.9 0.5 -0.3 1.9 2.1 0.3 1.1 0.6 0.6
Arm fat percentage (left) 0.5 2.0 7.3 0.6 -2.7 0.4 0.5 -2.4 -1.5 0.2 0.3 -1.3
Average weekly red wine intake 1.6 2.4 5.2 -1.8 2.1 -0.6 1.2 1.3 -1.1 -1.8 -2.3 -1.0
Handedness (chirality/laterality): Left-handed 1.2 1.4 5.4 -1.1 0.6 -2.3 0.4 0.8 -0.5 2.1 0.6 -0.1
Mood swings 0.6 1.1 4.0 -0.4 0.3 -1.3 1.3 0.2 -2.0 0.2 -0.4 -1.4
Loneliness, isolation 2.4 3.3 10.2 -1.3 1.9 0.5 -0.5 1.7 -1.1 -3.2 -2.9 -0.6
Long-standing illness, disability or infirmity 2.3 3.5 11.2 -1.9 1.1 -3.4 2.7 1.7 -2.0 0.1 -0.9 -0.5
Ever had bowel cancer screening 0.7 0.8 3.4 0.5 0.3 -0.5 -1.9 0.1 -0.9 -0.8 -0.8 -1.1
Diabetes diagnosed by doctor 0.2 0.3 0.6 0.1 -0.6 0.7 -0.5 0.6 0.6 -0.7 -0.1 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 3.7 -0.1 0.2 -1.9 -0.3 0.5 -0.5 0.4 0.5 0.5
Friendships satisfaction 2.2 2.7 6.8 -2.0 2.6 0.7 0.9 2.5 0.4 -1.4 -1.8 0.9
Qualifications: nursing, teaching 2.2 3.4 6.1 -2.2 2.0 0.1 2.2 1.4 -1.7 -2.2 -2.5 -1.1
Commuting to job workplace: Walk 2.0 2.2 6.1 2.5 -1.5 1.0 -1.3 -1.8 0.9 -0.3 1.3 1.8
Eye problems/disorders: Cataract 0.6 0.7 1.7 -0.5 0.9 -0.2 1.3 1.1 0.9 0.5 0.2 1.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.4 3.3 -0.7 0.8 0.1 -1.8 1.6 -0.9 -1.5 -1.4 -0.7
Medication for cholesterol 1.5 2.3 5.4 -1.5 1.3 1.4 0.9 1.8 -0.4 -2.3 -1.7 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.4 1.5 -0.5 -1.6 -0.8 -1.8 -0.8 -0.1 0.8 0.8
Back pain experienced in last month 0.3 0.5 1.7 0.2 -1.2 -1.3 -0.2 -0.3 -0.8 0.4 0.1 -0.1
Mineral and other dietary supplements 1.3 1.7 5.7 0.1 1.1 1.8 0.5 0.3 2.4 1.4 0.8 1.4
Breast cancer (self-reported) 0.7 0.9 3.5 -0.6 0.3 -1.2 0.4 0.2 -1.1 0.8 0.3 -1.9
Asthma (self-reported) 0.8 1.6 6.5 0.1 -0.8 -2.5 -0.1 -0.5 -2.1 0.9 0.6 -1.2
Osteoporosis (self-reported) 0.9 1.1 3.5 -0.2 0.4 -1.9 0.7 -0.4 -1.7 0.5 0.3 -1.4
Osteoarthritis (self-reported) 1.8 2.3 6.6 1.7 -0.3 -1.0 0.1 -1.6 0.9 2.6 2.3 1.4
Medication: Aspirin 0.4 0.5 1.4 0.4 -1.1 0.2 -0.6 -0.2 -1.2 -0.0 0.2 -1.2
Medication: Gliclazide 0.8 0.9 2.5 0.9 -0.7 1.6 -0.3 -0.6 1.4 0.6 0.8 0.8
Illnesses of father: None of the above (group 1) 2.4 3.0 9.4 -2.7 1.7 -0.9 0.8 3.1 -0.2 -1.5 -1.9 -0.2
Smoking status: Current 0.3 0.5 2.3 -0.3 -0.2 -0.8 1.5 -0.4 -0.9 -0.5 -0.1 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.1 -1.0 1.0 -1.0 0.8 -0.5 -0.9 1.0 0.0 -0.7
Whole body water mass 0.5 2.9 11.1 -2.8 1.8 -0.2 2.0 3.3 -0.1 0.3 -0.3 0.3
Leg predicted mass (right) 0.3 1.6 4.7 -1.9 0.6 -0.3 2.0 2.2 0.3 1.0 0.5 0.6
Arm fat mass (left) 0.2 0.8 2.5 -0.4 -1.6 0.3 1.0 -0.8 -1.2 0.3 0.1 -0.9
Number of self-reported non-cancer illnesses 1.5 2.7 14.4 0.4 -0.8 -3.8 -0.2 -1.0 -1.9 1.7 0.8 -0.8
Average weekly champagne plus white wine intake 3.6 5.0 13.5 -1.9 1.8 0.2 1.4 2.7 -1.7 -3.7 -3.3 -1.0
Miserableness 0.3 0.5 2.2 -0.5 0.6 -1.5 1.2 0.2 -0.6 0.0 -0.3 0.4
Guilty feelings 1.9 2.9 5.7 -2.3 1.5 0.9 0.5 2.0 -1.4 -1.6 -2.4 -1.8
Wears glasses or contact lenses 0.8 0.9 2.8 -0.3 -0.6 -0.8 0.1 -1.3 -1.3 0.5 -0.7 -1.7
Ever taken oral contraceptive pill 1.2 1.3 4.3 -1.5 0.4 -2.1 0.4 2.1 -0.5 0.1 -0.6 -0.3
Hearing aid user 0.8 0.9 3.7 0.0 -0.3 -1.1 -0.1 -0.8 -0.6 1.9 1.3 -0.9
Mother’s age at death 0.9 1.2 3.7 -0.5 1.9 0.2 0.8 0.9 -0.3 -1.5 -1.7 -0.1
Financial situation satisfaction 1.3 1.6 5.8 2.4 -0.8 0.5 -1.3 -1.3 1.0 0.0 1.2 1.3
Tinnitus: Yes, now most or all of the time 1.2 1.4 5.2 0.8 -1.3 -2.3 -1.8 -0.5 -0.2 1.0 0.9 -0.1
Commuting to job workplace: Public transport 3.4 4.0 8.2 -2.4 2.9 1.7 0.7 2.7 0.2 -2.5 -2.3 -0.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.7 0.7 -0.7 -0.1 0.4 -0.4 0.2 0.8 0.8 0.6
Medication: Blood pressure 1.4 2.7 4.5 1.6 -2.0 -2.1 -0.3 -2.1 -1.1 1.8 2.1 0.7
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.2 0.4 -0.7 -0.3 -0.8 -0.8 -0.8 -1.1 -1.1 -0.3
Supplements: Fish oil (including cod liver oil) 1.5 2.0 4.3 -1.1 -0.2 -0.7 -1.1 0.9 -1.8 -2.1 -1.8 -1.9
High cholesterol (Self-reported) 1.5 2.6 4.6 1.9 -2.1 0.9 -1.8 -2.1 0.7 1.8 1.7 0.3
Medication: Bendroflumethiazide 0.9 1.4 3.0 0.5 -1.7 -1.5 0.3 -1.4 -1.7 1.0 0.9 -0.2
Medication: Paracetamol 1.6 2.4 6.8 2.6 -2.0 -0.1 -1.8 -2.0 -0.5 1.1 1.4 -0.8
Medication: Lisinopril 2.4 3.1 7.8 2.6 -2.8 1.2 -2.5 -1.4 0.3 1.0 1.4 -0.4
Medication: Atorvastatin 1.4 1.7 4.8 1.4 -2.2 0.2 -0.5 -1.7 0.1 1.5 1.8 -0.4
Illnesses of father: High blood pressure 0.6 0.8 3.9 0.1 -0.6 2.0 0.9 -1.3 -0.0 0.1 0.7 -0.2
Alcohol drinker status: Never 0.3 0.3 1.8 -0.4 -0.1 -1.3 -0.6 0.3 0.2 -0.1 -0.5 -0.2
Ever smoked 0.4 0.8 2.9 -0.1 1.2 1.7 0.0 -0.1 1.3 -0.7 -0.5 0.4
Basal metabolic rate 0.4 2.1 7.4 -2.5 1.2 -0.2 1.9 2.7 -0.4 0.3 -0.2 0.1
Leg fat percentage (left) 0.4 1.4 5.0 0.9 -2.2 1.0 -0.4 -1.9 -1.1 -0.4 -0.2 -0.9
Arm fat-free mass (left) 0.5 2.4 9.4 -2.5 1.8 0.0 1.7 3.1 0.0 0.3 -0.2 0.4
Number of operations (self-reported) 0.5 0.7 1.8 -1.0 1.3 -1.1 1.4 -0.3 -0.5 0.2 -0.4 -0.1
Average weekly beer plus cider intake 0.7 1.0 3.0 1.1 0.0 0.4 0.9 -0.5 0.6 1.3 1.7 1.4
Irritability 0.4 0.7 1.9 -0.2 0.2 -0.2 0.1 1.4 0.6 1.2 0.8 1.4
Risk taking 1.7 2.4 9.2 -2.0 1.8 -1.4 1.3 3.0 0.0 -0.5 -1.2 0.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.3 -0.6 0.6 0.6 -0.1 0.1 -0.4 -1.1 -1.2 -1.5
Fractured/broken bones in last 5 years 0.8 1.0 3.6 -1.4 0.5 0.1 1.3 -0.2 -1.9 -0.6 -0.7 -0.6
Age started oral contraceptive pill 0.2 0.3 1.5 0.6 0.1 -1.2 -0.1 0.1 0.5 0.6 0.4 0.4
Diastolic blood pressure, automated reading 3.2 9.9 24.4 3.4 -4.9 -1.6 -1.2 -4.5 -2.9 2.6 3.3 -1.7
Ever depressed for a whole week 0.2 0.3 0.6 0.8 -0.2 0.6 0.6 -0.6 -0.2 -0.1 0.4 0.5
Unable to work because of sickness or disability 0.6 0.7 2.1 0.4 -0.5 -1.5 -0.5 -0.0 -0.5 1.4 1.2 0.3
Commuting to job workplace: Cycle 0.4 0.5 1.1 -0.2 0.8 -0.3 1.0 0.2 0.7 1.0 0.6 0.7
Myopia 0.4 0.6 1.8 0.5 -0.2 -1.3 0.9 -0.6 -0.6 0.5 1.1 0.8
Vascular/heart problems diagnosed by doctor 1.3 3.4 8.1 -2.0 2.9 1.3 0.6 2.7 1.5 -1.5 -2.2 -0.1
Cholesterol lowering medication 2.6 3.8 5.8 2.1 -1.6 1.4 -1.2 -2.0 2.2 2.4 2.2 2.1
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.4 -0.1 -0.6 0.5 -0.1 0.1 1.5 1.2 0.5 1.0
Pain experienced in last month 1.2 2.0 4.9 -1.6 1.7 2.2 2.0 1.0 0.2 -1.1 -0.6 -0.9
Supplements: Calcium 0.2 0.2 0.7 0.0 0.6 0.2 -0.0 -0.1 0.2 -0.9 -0.8 0.1
Basal cell carcinoma (self-reported) 0.4 0.5 1.1 -0.9 0.7 1.1 1.0 -0.0 0.3 0.5 -0.4 -0.5
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.3 0.4 -0.5 -0.7 0.0 -0.1 -0.1 1.1 1.1 0.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.2 -0.2 -0.2 -0.4 -0.5 -0.1 0.3 -0.3 -0.4
Heart disease (siblings) 0.2 0.3 1.0 -0.4 0.7 -0.6 0.3 1.0 -0.1 -0.0 0.2 0.7
Alcohol drinker status: Previous 0.9 1.0 3.3 -0.4 0.1 -0.6 -1.6 0.4 -0.1 -1.8 -1.5 -0.5
Pack years of smoking 1.1 1.5 4.5 1.0 -0.8 -1.8 1.2 -0.2 0.6 0.6 1.5 2.1
Impedance of whole body 0.1 0.7 1.7 0.4 -0.7 -1.0 0.8 -1.3 -0.9 0.2 0.2 -1.1
Leg fat mass (left) 0.2 0.7 2.9 0.2 -1.7 0.9 0.3 -1.0 -0.8 0.3 0.2 -0.7
Arm predicted mass (left) 0.5 2.6 10.4 -2.6 1.9 0.0 1.7 3.2 -0.2 -0.1 -0.5 0.3