[Hub]/) : Traits : Heel T-Score : ← →

chr4:57,080,198-58,593,295

Best TWAS P=3.3e-21 · Best GWAS P=1.29e-23 conditioned to 0.000838

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex POLR2B 0.09 0.05 bslmm 572 0.02 4.7e-04 -4.1 -6.3 2.8e-10 -0.53 0.68 0.21 FALSE
2 GTEx Artery Aorta NOA1 0.17 0.06 lasso 4 0.06 3.5e-04 -5.3 8.2 2.3e-16 0.85 0.07 0.84 FALSE
3 GTEx Colon Transverse REST 0.26 0.04 lasso 9 0.10 1.9e-05 7.4 6.4 2.0e-10 0.59 0.21 0.50 FALSE
4 GTEx Muscle Skeletal REST 0.05 0.01 enet 9 0.02 3.9e-03 9.0 8.5 1.8e-17 0.85 0.02 0.97 FALSE
5 GTEx Nerve Tibial NOA1 0.08 0.02 enet 5 0.02 1.5e-02 2.7 5.5 3.9e-08 0.50 0.31 0.11 FALSE
6 GTEx Testis REST 0.15 0.08 enet 12 0.04 7.4e-03 8.0 7.2 6.1e-13 0.76 0.08 0.88 FALSE
7 GTEx Thyroid NOA1 0.08 0.03 lasso 5 0.03 1.7e-03 5.8 5.5 4.2e-08 0.57 0.32 0.31 FALSE
8 METSIM Adipose RP11-738E22.3 0.07 0.04 lasso 6 0.05 7.7e-08 8.1 -8.7 3.0e-18 -0.84 0.13 0.87 FALSE
9 ROSMAP Brain Pre-frontal Cortex REST 0.04 0.02 bslmm 536 0.02 3.4e-03 10.0 7.2 8.4e-13 0.74 0.01 0.98 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C4orf14 0.03 0.04 lasso 3 0.04 1.9e-05 8.1 7.9 2.4e-15 0.81 0.02 0.92 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma REST 0.04 0.01 lasso 5 0.02 7.8e-04 8.0 8.9 3.9e-19 0.84 0.01 0.94 FALSE
12 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C4orf14 0.13 0.11 lasso 2 0.10 6.2e-05 10.0 9.4 3.3e-21 0.93 0.00 0.96 TRUE
13 The Cancer Genome Atlas Thyroid Carcinoma C4orf14 0.07 0.05 blup 57 0.06 3.2e-06 -2.9 5.9 3.6e-09 0.63 0.23 0.73 FALSE